Researchers Database

yoshida naohiro

    ComprehensiveMedicine2 Professor
Last Updated :2021/12/08

Researcher Information


Research funding number

  • 90291260

J-Global ID

Research Interests

  • 蝸牛   音響外傷   好酸球性中耳炎   騒音性難聴   有毛細胞   コンディショニング効果   熱ストレス   内耳   耳管ピン   Kir4.1   cochlea   gap junction   音響学的診断法   耳管   inner ear   耳管開放症   座位CT   老人性難聴   遺伝性難聴   高度感音性難聴   三叉神経   腎透析   endocochlear potential   内リンパ電位(EP)   内耳障害   カリウム循環   蝸牛内移植   自声強聴   potassium ion   outer sulcus epithelium   

Research Areas

  • Life sciences / Otorhinolaryngology

Academic & Professional Experience

  • 2011  Jichi Medical UniversitySchool of Medicine准教授


  • Kanazawa Hiromi, Hasegawa Masayo, Hara Mariko, Matsuzawa Shingo, Shinnabe Akihiro, Yoshida Naohiro, Iino Yukiko  JOURNAL OF JAPAN SOCIETY FOR HEAD AND NECK SURGERY  23-  (1)  49  -54  2013  [Not refereed][Not invited]
    Objective: To compare the growth of secondary and primary cholesteatoma (pars tensa retraction type). Methods: This study included 22 ears with secondary cholesteatoma (secondary group) and 3 ears with pars tensa type cholesteatoma (pars tensa group) that underwent primary tympanoplasty during a period of 4 years. They were evaluated in terms of the following parameters: age at the time of tympanoplasty, otoscopic findings, hearing acuity, extent of ossicular destruction, and development of mastoid air cells. Results: The cholesteatoma matrix in the secondary group was mostly found around the malleus handle and was significantly limited to within the epitympanum, while that in the pars tensa group was rarely adjacent to the malleus handle and extended to the mastoid. Ossicular destruction of the incus and superstructure of the stapes was less frequently seen in the secondary group than in the pars tensa group. Development of mastoid air cells was significantly better in the secondary group than in the pars tensa group. Conclusions: The two groups of patients showed significantly different clinical characteristics. The cholesteatomas in the secondary group tended to ascend to the surface of the ossicle. The cause of the abnormal proliferation of epithelial migration was unknown. Long-term recurrent infection or an apparent episode (such as trauma or history of insertion of a tympanic tube) is not necessarily needed for the onset.
  • YOSHIDA N  Practica Oto-Rhino-Laryngologica  105-  (3)  290  -291  2012/03  [Not refereed][Not invited]
  • Shingo Matsuzawa, Masayo Hasegawa, Mariko Hara, Akihiro Shinnabe, Hiromi Kanazawa, Naohiro Yoshida, Yukiko Iino  Practica Oto-Rhino-Laryngologica  105-  (12)  1149  -1153  2012  [Not refereed][Not invited]
    Osteoradionecrosis of the temporal bone can occur after radiotherapy for head and neck cancer and brain tumors, such as parotid cancer and upper pharyngeal cancer. It sometimes causes external auditory canal cholesteatoma. We report herein on a 17-year-old female who received chemoradiation therapy for a brain tumor at the age of 10 years. Several years later, ear wax and debris began to accumulate in both external auditory canals. She also lost hearing in both ears. A CT scan showed extensive lytic change of both temporal bones. The semicircular canals of the right ear were also eroded. Pure tone audiometry showed moderate mixed hearing loss of the right ear and moderate conductive hearing loss of the left ear. We diagnosed an external auditory canal cholesteatoma caused by osteoradionecrosis extending to the middle ear. Although there has been no progression of her temporal bone lysis on imaging, the bone conduction hearing level of both ears had gradually deteriorated. She was treated conservatively by cleaning out the crust and debris, and systemic administration of a corticosteroid when the bone conduction hearing level worsened. Careful follow-up over a long time is needed to prevent serious complications.
  • HARA Mariko, HASEGAWA Masayo, MATZUZAWA Shingo, KODAMA Kozue, SHINNABE Akihiro, KANAZAWA Hiromi, YOSHIDA Naohiro, IINO Yukiko  Otology Japan  21-  (3)  222  -226  2011/07  [Not refereed][Not invited]
    Middle ear cholesteatoma shows often a gradually expanding growth destroying the temporal bone or ossicles, but is sometimes accompanied by abnormal calcification or ossification called tympanosclerosis. Here we studied the clinical characteristics of cholesteatoma with sclerotic regions. In our hospital 168 patients with cholesteatoma underwent tympanoplasty for the first time from March 2006 to March 2010. Among them, 33 showed sclerotic regions. We compared the patients with sclerotic regions and those without them, and the patients of chronic otitis media with tympanosclerosis. Sclerotic regions were found in any type of cholesteatoma and often existed next to the cholesteatoma matrix. Our findings suggest some close relationship between cholesteatoma and tympanosclerosis. In addition, some unique mechanism may be responsible for sclerotic change in cholesteatoma.
  • SHINNABE Akihiro, HARA Mariko, MATSUZAWA Shingo, HASEGAWA Masayo, KODAMA Kozue, KANAZAWA Hiromi, KANAZAWA Takeharu, YOSHIDA Naohiro, IINO Yukiko  Otology Japan  21-  (1)  8  -12  2011/02  [Not refereed][Not invited]
    To clarify whether adult patients with attic cholesteatoma show clinical features that differ with age, 99 ears of the patients with attic cholesteatoma who underwent canal wall reconstruction tympanoplasty in our hospital were included in this study. Patients who had already undergone tympanoplasty in other hospital were excluded. They were divided into the following two groups according to their age; younger age group consisted of the patients in their twenties and thirties, and elderly age group consisted of the patients in their fifties and sixties. The following three items were analyzed in the patients of both age groups.1) The size of mastoid cells measured by preoperative temporal bone CT.2) The extent of middle ear aeration evaluated by postoperative temporal bone CT.3) Postoperative hearing.Statistical analyses were carried out using the unpaired t-test and the χ<SUP>2</SUP> test. P values of less than 0.05 were considered statistically significant.As the results, compared with elderly age group, younger age group showed the following statistically significant differences. 1) Larger size of the mastoid cells. (P<0.001, t test).2) Better postoperative mastoid aeration (P<0.001, χ<SUP>2</SUP> test).3) Better hearing outcomes (P<0.001, χ<SUP>2</SUP> test).It was concluded that adult patients with attic cholesteatoma showed different clinical features depending on their age. This suggested that there may be some etiological differences between the two age groups.
  • 吉田 征之, 吉田 尚弘, 菊地 俊晶, 大島 猛史, 川瀬 哲明, 小林 俊光  Otology Japan  18-  (4)  2008/09  [Not refereed][Not invited]
  • 和田 仁, 吉田 尚弘, 小林 俊光  Audiology Japan  50-  (5)  397  -398  2007/09  [Not refereed][Not invited]
  • 村越 道生, 吉田 尚弘, 橘内 葉子  聴覚研究会資料  37-  (7)  569  -574  2007/08  [Not refereed][Not invited]
  • MURAKOSHI Michio, YOSHIDA Naohiro, KITSUNAI Yoko, IIDA Koji, KUMANO Shun, SUZUKI Takashi, KOBAYASHI Toshimitsu, WADA Hiroshi  Technical report of IEICE. EA  107-  (187)  19  -24  2007/08  [Not refereed][Not invited]
    Noise-induced hearing loss was reported to be decreased by raising the body temperature before traumatic noise exposure, i.e., heat stress. However, the protective mechanism of the inner ear against such traumatic exposure remains unknown. In the present study, the mechanical properties and the amount of filamentous actin of outer hair cells (OHCs) in mice with or without heat stress were measured by atomic force microscopy and confocal laser scanning microscopy, respectively. The conditioning by heat stress caused an increase in F-actin of the OHCs, leading to an increase in their Young's modulus. These results suggest that OHCs exposed to prior heat stress possibly experience less strain when they are exposed to loud noise, resulting in protection from traumatic noise exposure.
  • Masaru Tateda, Takayuki Kudo, Jun Hasegawa, Shun Sagai, Makiko Miyazaki, Ayako Nakanome, Kiyoshi Oda, Naohiro Yoshida, Toshimitsu Kobayashi  Journal of Otolaryngology of Japan  110-  (6)  453  -460  2007/06  [Not refereed][Not invited]
    Unlike other advanced nations, secondary spread of tuberculosis still occurs in Japan. Cervical tuberculous lymphadenitis is still an important disease of the neck, and between 2001 to 2005, we treated 6 patients with cervical tuberculous lymphadenitis. All 6 patients were females, and their ages ranged from 28 to 77 years old (average : 62 years). One patient had received antitubercular chemotherapy for pulmonary tuberculosis 40 years earlier. Two patients had a family history of pulmonary tuberculosis. One patient was an immigrant from Thailand. Three patients underwent open biopsy of the cervical lymph node, and were diagnosed with tuberculosis histologically. The remaining three patients had an abscess, and fine-needle aspiration (FNA) biopsy was performed. The diagnosis of tuberculosis was made by detection of acid-fast bacilli, MTD (Mycobacterium tuberculosis direct test), PCR (polymerase chain reaction), and culture. All six patients were treated with antitubercular chemotherapy for 6-9 months and recovered. MTD and PCR of the FNA sample seemed to enable early treatment. Attention needs to be paid to countries around Japan where tuberculosis is spreading. We suggest that treatment should be performed while at the same time making an effort to grasp the trend of spread in other countries as well as Japan.
  • MURAKOSHI Michio, YOSHIDA Naohiro, KITSUNAI Yoko, IIDA Koji, KUMANO Shun, SUZUKI Takashi, KOABAYASHI Toshimitsu, WADA Hiroshi  バイオエンジニアリング講演会講演論文集  2006-  (19)  44  -45  2007/01  [Not refereed][Not invited]
  • KITSUNAI Yoko, MURAKOSHI Michio, YOSHIDA Naohiro, KOBAYASHI Toshimitsu, WADA Hiroshi  バイオエンジニアリング講演会講演論文集  2006-  (19)  380  -381  2007/01  [Not refereed][Not invited]
  • MURATANI Asako, KITSUNAI Yoko, MURAKOSHI Michio, YOSHIDA Naohiro, KOBAYASHI Toshimitsu, WADA Hiroshi  バイオエンジニアリング講演会講演論文集  2006-  (19)  382  -383  2007/01  [Not refereed][Not invited]
  • Naohiro Yoshida, Toshimitsu Kobayashi  Practica Oto-Rhino-Laryngologica  100-  (5)  323  -331  2007  [Not refereed][Not invited]
    Acoustic trauma remains a most important issue in technologically advanced countries. Overexposure to intense sound damages the inner ear sensory cells and can lead to temporary threshold shift (TTS) or permanent threshold shift (PTS) if exposure is sufficiently intense or prolonged. This review includes the recent findings of histological, metabolic, physiological changes after sound exposure and the proposed mechanisms for protection from acoustic injury. Cats, guinea pigs and mice are widely used as experimental models for hearing research. Recently, mice have been more frequently used because their genomic information and lower degree of inter-animal variability in the response to sound exposure. Overexposure damages the cochlea in two ways, i.e. mechanical and metabolic pathways. In mice, intense exposure (over 116 dB SPL 2 hours, 8 kHz octave band noise) simultaneously damages the organ of corti and stria vascularis by mostly mechanical pathways. However, sound exposure (112 dB SPL 2 hours, 8 kHz octave band noise) damaged the organ of Corti within a week by mechanical and metabolic pathways. The first row of outer hair cells is the most vulnerable to sound. Sound exposure (100 dB SPL 2 hours, 8 kHz octave band noise), which showed damage to only the first row of outer hair cells in histological findings, causes 40 dB PTS. To prevent and protect PTS from sound exposure, some factors or reagents have been identified in animal models, 1) efferent reflex via the olivocochlear bundle (OCB) animals with a large OCB reflex are resistant to sound. 2) conditioning effect "conditioning" the ear by pre-exposure to a moderate level, nontraumatic sound or heat stress, restraint can dramatically reduce the development of PTS by subsequent sound exposure. 3) Reactive oxygen substances (ROS) scavenger, glutathione oxidative stress damages the tissue, while ROS scavenger can protect the ear from sound exposure. 4) blocker of glutamate, or neutrophine, 5) steroid. Some reagents have been examined in humans as clinical trial in the US.
  • 和田 仁, 吉田 尚弘, 小林 俊光  Audiology Japan  48-  (5)  509  -510  2005/09  [Not refereed][Not invited]
  • 村越 道生, 吉田 尚弘, 小林 俊光, 和田 仁  日本バイオレオロジー学会年会抄録集  28-  2005/06  [Not refereed][Not invited]
  • MURAKOSHI Michio, YOSHIDA Naohiro, KOBAYASHI Toshimitsu, WASA Hiroshi  Proceedings of the ... JSME Conference on Frontiers in Bioengineering  2004-  (15)  7  -8  2004/11  [Not refereed][Not invited]
  • 千葉 敏彦, 吉田 尚弘, 佐藤 利徳, 川瀬 哲明, 菊地 俊彦, 大島 猛史, 小林 俊光  Otology Japan  14-  (4)  2004/09  [Not refereed][Not invited]
  • 吉田 尚弘, 小林 俊光  Otology Japan  14-  (4)  2004/09  [Not refereed][Not invited]
  • KOBAYASHI T  Practica Oto-Rhino-Laryngologica  97-  (1)  6  -7  2004/01  [Not refereed][Not invited]
  • 吉田 尚弘, 須納瀬 弘, 千葉 敏彦, 小林 俊光  Otology Japan  13-  (4)  2003/09  [Not refereed][Not invited]
  • 千葉 敏彦, 菊地 俊彦, 吉田 尚弘, 小林 俊光  Otology Japan  13-  (4)  2003/09  [Not refereed][Not invited]

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