Researchers Database

matsuyama yasushi

    Medical Education Center Associate Professor
Last Updated :2022/05/19

Researcher Information


J-Global ID

Research Interests

  • Community medicine   Self-regulated learning   Progress test   Medical Education   サイトカイン   関節リウマチ   インターロイキン33   

Research Areas

  • Life sciences / Healthcare management, medical sociology
  • Life sciences / Allergies and connective tissue disease

Academic & Professional Experience

  • 2011 - Today  Jichi Medical UniversityMedical Education Center
  • 2018/04 - 2020/03  Gifu University医学教育開発研究センター客員教授
  • 2010 - 2011  Jichi Medical UniversitySchool of Medicine研究員


  • 2016/06 - 2020/10  Maastricht University,  School of Health Professons Education, PhD course
  • 2013/05 - 2015/06  Maastricht University,  Faculty of Health, Medicine and Life Sciences,  Master Course of Health Professions Education
  • 2008/04 - 2011/03  Jichi Medical University Graduate School  Doctor Course of Medical Science

Published Papers

  • Matsuyama Y, Nishiya K, Fujisaki K
    Medical Education (Japan) (一社)日本医学教育学会 52 (6) 503 - 508 0386-9644 2021/12 [Invited]
    2014年から正式運用されている医学教育専門家制度は、今日までに181名の専門家を輩出している。医学教育のグローバル化に対応し、国際基準に沿った教育改善に取り組むことができる実践的専門家を育成する体制が確立したように思われた。しかし、新型コロナウイルス感染症の流行によって対面型の履修コースを開催できなくなり、対面協働学習を活用していた従来の育成体制は見直しを迫られた。2021年2月、フルオンライン型で履修コースを再開した。オンライン学習に集中できる時間を考慮して事前学習コンテンツを充実させ、学習プラットフォームとしてMoodleを使用し、当日のレクチャーやグループワークをZoomで行った。大きな回線トラブルはなく、コース後のアンケートの結果、受講者の満足度、学習の有用度は高かった。本コースが新たな教育体系のgood practiceとなるよう、対面型とオンライン型の強みを取り入れて発展させていきたい。(著者抄録)
  • Current status and prospects of community-based medical education: A discussion based on the special symposium "evolution and essence of the community-based medical education through COVID-19 pandemic"
    Yasushi Matsuyama, Kazuhiko Kotani, Takahiro Maeda
    Medical Education (Japan) 52 (5) 421 - 426 2021/10 [Refereed][Invited]
  • Yasushi Matsuyama, Hitoaki Okazaki, Kazuhiko Kotani, Yoshikazu Asada, Shizukiyo Ishikawa, Adam Jon Lebowitz, Jimmie Leppink, Cees van der Vleuten
    The Asia Pacific Scholar 6 (4) 49 - 64 2424-9335 2021/10 [Refereed][Not invited]
    Introduction: Previous studies indicate that professional identity formation (PIF), the formation of a self-identity with the internalised values and norms of professionalism, may influence self-regulated learning (SRL). However, it remains unclear whether a PIF-oriented intervention can improve SRL in clinical education. The aim of this study was to explore whether a PIF-oriented mentoring platform improves SRL in a clinical clerkship. Methods: A mixed-methods study was conducted. Forty-one students in a community-based clinical clerkship (CBCC) used a PIF-oriented mentoring platform. They articulated the values and norms of professionalism in a professional identity essay, elaborated on future professional self-image, and reflected on their current compared to future selves. They made a study plan while referring to PIF-based self-reflection and completed it. The control group of 41 students completed CBCC without the PIF-oriented mentoring platform. Changes in SRL between the two groups were quantitatively compared using the Motivated Strategies for Learning Questionnaire. We explore how PIF elements in the platform affected SRL by qualitative analysis of questionnaire and interview data. Results: A moderate improvement in intrinsic goal orientation (p = 0.005, ε2 = 0.096) and a mild improvement in critical thinking (p = 0.041, ε2 = 0.051) were observed in the PIF-oriented platform group. Qualitative analysis revealed that the PIF-oriented platform fostered professional responsibility as a key to expanding learning goals. Gaining authentic knowledge professionally fostered critical thinking, and students began to elaborate knowledge in line with professional task processes. Conclusion: A PIF-oriented mentoring platform helped students improve SRL during a clinical clerkship.
  • Masatoshi Matsumoto, Yasushi Matsuyama, Saori Kashima, Soichi Koike, Yuji Okazaki, Kazuhiko Kotani, Tetsuhiro Owaki, Shizukiyo Ishikawa, Seitaro Iguchi, Hitoaki Okazaki, Takahiro Maeda
    Human Resources for Health 19 102  2021/08 [Refereed]
    Abstract Background Japan has established comprehensive education-scholarship programs to supply physicians in rural areas. Their entrants now comprise 16% of all medical students, and graduates must work in rural areas for a designated number of years. These programs are now being adopted outside Japan, but their medium-term outcomes and inter-program differences are unknown. Methods A nationwide prospective cohort study of newly licensed physicians 2014–2018 (n = 2454) of the four major types of the programs—Jichi Medical University (Jichi); regional quota with scholarship; non-quota with scholarship (scholarship alone); and quota without scholarship (quota alone)—and all Japanese physicians in the same postgraduate year (n = 40,293) was conducted with follow-up workplace information from the Physician Census 2018, Ministry of Health, Labour and Welfare. In addition, annual cross-sectional survey for prefectural governments and medical schools 2014–2019 was conducted to obtain information on the results of National Physician License Examination and retention status for contractual workforce. Results Passing rate of the National Physician License Examination was highest in Jichi, followed in descending order by quota with scholarship, the other two programs, and all medical graduates. The retention rate for contractual rural service of Jichi graduates 5 years after graduation (n = 683; 98%) was higher than that of quota with scholarship (2868; 90%; P < 0.001) and scholarship alone (2220; 81% < 0.001). Relative risks of working in municipalities with the least population density quintile in Jichi, quota with scholarship, scholarship alone, and quota alone in postgraduate year 5 were 4.0 (95% CI 3.7–4.4; P < 0.001), 3.1 (2.6–3.7; < 0.001), 2.5 (2.1–3.0; < 0.001), and 2.5 (1.9–3.3; < 0.001) as compared with all Japanese physicians. There was no significant difference between each program and all physicians in the proportion of those who specialized in internal medicine or general practice in postgraduate years 3 to 5 Conclusions Japan’s education policies to produce rural physicians are effective but the degree of effectiveness varies among the programs. Policymakers and medical educators should plan their future rural workforce policies with reference to the effectiveness and variations of these programs.
  • 松山泰
    月間地域医学 (公社)地域医療振興協会 35 (7) 625 - 629 0914-4277 2021/07 [Not refereed][Invited]
    <POINT>(1)Learning Management Systemの活用とオンライン教育に詳しい専門家のリーダーシップが迅速なリモート教育導入の鍵であった(2)リモート教育でも体験できる学習対象を明確にした上でコンテンツ開発を進めるとよい(3)リモート教育が難しい精神運動領域と情意領域の学習は、自習教材の工夫とメンタリングの充実化で対応するとよい(4)官民協働オールジャパンで緊急時のリモート教育体制を確立していくべきである(著者抄録)
  • Yoshikazu Asada, Hitoaki Okazaki, Naohiro Sata, Hiroshi Kawahira, Shinichi Yamamoto, Yasushi Matsuyama
    International Journal of Institutional Research and Management 5 (1) 30 - 44 2432-3675 2021/06 [Refereed][Not invited]
  • Ikuo Shimizu, Yasushi Matsuyama, Robbert Duvivier, Cees van der Vleuten
    BMC Medical Education 21 (1) 2021/04 [Refereed]
    Abstract Background Problem-based learning (PBL) is classified as a collaborative learning approach, wherein students learn while contributing meaning to experiences and interactions with others. An important theoretical fundament of PBL is social interdependence theory (SIT) because positive social interdependence within a group has been found to be key to better learning performance and future attitudes towards team practice. However, most previous studies in health professions education focused on cognitive outcomes, and few studies have focused on collaborative behaviors in PBL groups. The lack of this empirical insight makes implementation of PBL difficult, especially in contexts where there is limited experience with collaborative learning. Therefore, the aim of this study was to elucidate what promotes or hinders positive social interdependence and how the attributes work during PBL. Methods We conducted four focus groups among clinical year medical students (n = 26) who participated in PBL tutorials in the formal curriculum. We asked semi-structured questions that corresponded with the overall concept of SIT. We analyzed the transcript using constructivist grounded theory and developed a model to explain contextual attributes that promote or hinder positive social interdependence in PBL. Results Two contextual attributes of “academic inquisition” and “desire for efficiency” affect social interdependence among a student group in PBL. Academic inquisition is students’ desire to engage in their academic learning, and desire for efficiency is students’ attitude toward learning as an imposed duty and desire to complete it as quickly as possible. These attributes are initially mutually conflicting and constructing social interdependence through multiple steps including inquisition from a case, seeking efficient work, sharing interest in problem solving, expecting mutual contributions, and complementing learning objectives. Conclusion These findings will contribute to understanding collaborative learning environments in PBL and may help explain contexts where PBL is less successful. The model can also be used as a tool to support innovation of PBL as collaborative learning.
  • Yasushi Matsuyama, Motoyuki Nakaya, Jimmie Leppink, Cees van der Vleuten, Yoshikazu Asada, Adam Jon Lebowitz, Teppei Sasahara, Yu Yamamoto, Masami Matsumura, Akira Gomi, Shizukiyo Ishikawa, Hitoaki Okazaki
    BMC Medical Education 21 (1) 30 - 30 2021/01 [Refereed]
    Abstract Background Developing self-regulated learning in preclinical settings is important for future lifelong learning. Previous studies indicate professional identity formation, i.e., formation of self-identity with internalized values and norms of professionalism, might promote self-regulated learning. We designed a professional identity formation-oriented reflection and learning plan format, then tested effectiveness on raising self-regulated learning in a preclinical year curriculum. Methods A randomized controlled crossover trial was conducted using 112 students at Jichi Medical University. In six one-day problem-based learning sessions in a 7-month pre-clinical year curriculum, Groups A (n = 56, female 18, mean age 21.5y ± 0.7) and B (n = 56, female 11, mean age 21.7y ± 1.0) experienced professional identity formation-oriented format: Group A had three sessions with the intervention format in the first half, B in the second half. Between-group identity stages and self-regulated learning levels were compared using professional identity essays and the Motivated Strategies for Learning Questionnaire. Results Two-level regression analyses showed no improvement in questionnaire categories but moderate improvement of professional identity stages over time (R2 = 0.069), regardless of timing of intervention. Conclusions Professional identity moderately forms during the pre-clinical year curriculum. However, neither identity nor self-regulated learning is raised significantly by limited intervention.
  • 元日田 和規, 田川 まさみ, 西城 卓也, 菊川 誠, 高村 昭輝, 岡崎 仁昭, 松山 泰, 守屋 利佳, 千葉 宏毅, 高木 康, 瀬戸山 仁, 富原 一哉
    医学教育 (一社)日本医学教育学会 51 (Suppl.) 127 - 127 0386-9644 2020/07
  • 淺田 義和, 岡崎 仁昭, 佐田 尚宏, 川平 洋, 山本 真一, 松山 泰
    医学教育 (一社)日本医学教育学会 51 (Suppl.) 170 - 170 0386-9644 2020/07
  • 自治医大マルチメディア形式総合判定試験の11年の解析 医療面接・臨床推論連問の導入
    鈴木 真紀, 松山 泰, 淺田 義和, 三重野 牧子, 川平 洋, 武藤 弘行, 石川 鎮清, 岡崎 仁昭
    医学教育 (一社)日本医学教育学会 51 (Suppl.) 215 - 215 0386-9644 2020/07
  • Ryuichi Ohta, Takuji Katsube, Yasushi Matsuyama
    Medical Education (Japan) (一社)日本医学教育学会 51 (3) 326 - 327 0386-9644 2020/06 [Refereed][Not invited]
  • Development of Moodle-Based Distance Learning Environment For Connecting Tochigi to Forty-seven Prefectures
    Yoshikazu Asada, Hitoshi Endo, Motoshi Kikuchi, Yasuko Noda, Shizukiyo Ishikawa, Yasushi Matsuyama, Hitoaki Okazaki, Masami Matsumura
    Medical Education (Japan) 51 (3) 236 - 237 2020/06 [Refereed][Not invited]
  • Alternative Contents for Clinical Clerkship, and Pre- and Post-CC OSCE: A Proposal from Kawakita Group
    Yasushi Matsuyama, Hitoaki Okazaki, Yoshikazu Asada, Hiroyuki Kurihara, Shigeru Ueda, Nobutaro Ban, Hirobumi Kawakita, Morito Monden
    Medical Education (Japan) 51 (3) 216 - 218 2020/06 [Refereed][Not invited]
  • 地域プライマリ・ケア医の視点で学ぶアレルギー総論
    月刊地域医学 34 (3) 179 - 184 2020/03 [Not refereed][Invited]
  • Using text mining to analyze reflective essays from Japanese medical students after rural community placement
    Adam Levowitz, Kazuhiko Kotani, Yasushi Matsuyama, Masami Matsumura
    BMC Medical Education 20 38  2020/02 [Refereed][Not invited]
  • A survey of international medical education journals and the number of articles published from Japan
    Yasushi Matsuyama
    Medical Education (Japan) 50 (6) 545 - 549 2019/12 [Not refereed][Not invited]
  • Use of medical simulators for self-learning among undergraduates in Japan
    Yagi M, Matsuyama Y, Asada Y, Hiroe T, Suzuki Y
    Medical Education (Japan) 50 (5) 495 - 499 2019/11 [Refereed][Not invited]
  • Self-awareness of being 'unique to others' promotes self-regulated learning
    Yasushi Matsuyama
    Medical Education (Japan) 50 (4) 357 - 361 2019/08 [Not refereed][Invited]
  • Matsuyama Y, Nakaya M, Okazaki H, Lebowitz AJ, Leppink J, van der Vleuten C
    BMC Medical Education 19 152  2019/05 [Refereed][Not invited]
  • Revising JASMEE guidelines in accordance with standards in medical education research may improve the quality of English for Medical Purposes studies
    Adam Lebowitz, Yasushi Matsuyama
    J Med Eng Educ 18 (3) 116 - 117 2019 [Refereed][Not invited]
  • What and How to Learn in Medical Schools : A Case Study of First-year Experience in Class
    Yoshikazu Asada, Yoshihiro Itai, Yasushi Matsuyama
    Medical education (Japan) 49 (5) 461 - 465 2018/10 [Not refereed][Not invited]
  • Hiroshi Nishigori, Sayaka Oikawa, Yasushi Matsuyama, Hironobu Fujiwara
    Medical Education (Japan) 日本医学教育学会 49 (4) 283 - 287 0386-9644 2018/08 [Not refereed][Invited]
  • Ottawa Conference
    Yasushi Matsuyama, Takuya Saiki
    Medical Education (Japan) 49 (3) 186 - 187 2018/06 [Not refereed][Invited]
  • Hirotaka Kimura, Yasushi Matsuyama, Sachiko Araki, Atsushi Koizumi, Yumi Kariya, Shunsuke Takasuga, Satoshi Eguchi, Hiroki Nakanishi, Junko Sasaki, Takehiko Sasaki
    Modern Rheumatology 28 (3) 530 - 541 1439-7609 2018/05 [Refereed][Not invited]
    Objective: Neutrophil extracellular traps (NETs) are peculiar structures composed of the externalized chromatin with intracellular proteins and formed by activated neutrophils in a reactive oxygen species (ROS)-dependent manner. Aberrant NETs are considered to be autoantigens for anti-neutrophil cytoplasmic antibodies (ANCAs) underling the development of microscopic polyangiitis (MPA). However, little is known regarding the therapeutic efficacy of in vivo inhibition of NET formation (NETosis) on MPA pathogenesis. This study determines whether reducing NETosis prevents ANCA production and improves characteristic involvement. Methods: A mouse model of MPA induced by administering a novel extract from Candida albicans was devised. By applying this method to mice lacking phosphoinositide 3-kinase gamma (PI3K-gamma), which is indispensable for ROS production in neutrophils, we investigated the levels of in vivo NETs, ANCA titers and histological damage. Results: Our model exhibited accumulation of NETs in vivo, elevation of ANCA titers and characteristic pathologies mimicking human MPA, including small-vessel vasculitis and crescentic glomerulonephritis. Strikingly, these abnormalities were reduced by genetically and/or pharmacologically blocking PI3K-gamma. Moreover, a pharmacological PI3K-gamma blockade decreased the levels of human NETs. Conclusion: Our results suggest that in vivo inhibition of NETosis by blocking PI3K-gamma could be a promising therapeutic strategy for the pathogenesis of MPA.
  • Yasushi Matsuyama, Motoyuki Nakaya, Hitoaki Okazaki, Jimmie Leppink, Cees van der Vleuten
    Medical Teacher 40 (3) 285 - 295 1466-187X 2018/03 [Refereed][Not invited]
    Background and objectives: Previous studies support the notion that East Asian medical students do not possess sufficient self-regulation for postgraduate clinical training. However, some East Asian physicians who are employed in geographically isolated and educationally underserved rural settings can self-regulate their study during the early phase of their postgraduate career. To explore the contextual attributes that contribute to self-regulated learning (SRL), we examined the differences in self-regulation between learning as an undergraduate and in a rural context in East Asia. Methods: We conducted interviews and diary data collection among rural physicians (n = 10) and undergraduates (n = 11) in Japan who undertook self-study of unfamiliar diseases. We analyzed three domains of Zimmerman’s definition of SRL: learning behaviors, motivation, and metacognition using constructivist grounded theory. Results: Rural physicians recognized their identity as unique, and as professionals with a central role of handling diseases in the local community by conducting self-study. They simultaneously found themselves being at risk of providing inappropriate aid if their self-study was insufficient. They developed strategic learning strategies to cope with this high-stakes task. Undergraduates had a fear of being left behind and preferred to remain as one of the crowd with students in the same school year. Accordingly, they copied the methods of other students for self-study and used monotonous and homogeneous strategies. Conclusions: Different learning contexts do not keep East Asian learners from being self-regulated. Awareness of their unique identity leads them to view learning tasks as high-stakes, and to initiate learning strategies in a self-regulated manner. Teacher-centered education systems cause students to identify themselves as one of the crowd, and tasks as low-stakes, and to accordingly employ non-self-regulated strategies.
  • 【地域ケアの実践知】 教育からみた地域ケア 大学医学部から考える地域ケア教育
    松山 泰, 竹島 太郎
    治療 (株)南山堂 100 (3) 318 - 323 0022-5207 2018/03 [Not refereed][Not invited]
  • 【マルチプロブレムの高齢者薬物治療】 関節リウマチ×ステロイド糖尿病×骨粗鬆症
    松山 泰
    薬事 (株)じほう 59 (7) 1432 - 1438 0016-5980 2017/05 [Not refereed][Not invited]
  • Yasushi Matsuyama, Arno M. M. Muijtjens, Makoto Kikukawa, Renee Stalmeijer, Reiko Murakami, Shizukiyo Ishikawa, Hitoaki Okazaki
    BMC MEDICAL EDUCATION 16 245  1472-6920 2016/09 [Refereed][Not invited]
    Background: Progress testing (PT) is used in Western countries to evaluate students' level of functional knowledge, and to enhance meaning-oriented and self-directed learning. However, the use of PT has not been investigated in East Asia, where reproduction-oriented and teacher-centered learning styles prevail. Here, we explored the applicability of PT by focusing on student perceptions. Methods: Twenty-four students from Years 2, 3, and 5 at Jichi Medical University in Japan attended a pilot PT session preceded by a brief introduction of its concept and procedures. Variations in obtained test scores were analyzed by year, and student perceptions of PT were explored using focus groups. Results: Formula scores (mean +/- standard deviation) in Years 2, 3, and 5 were 12.63 +/- 3.53, 35.88 +/- 14.53, and 71.00 +/- 18.31, respectively. Qualitative descriptive analysis of focus group data showed that students disfavored testing of medical knowledge without tangible goals, but instead favored repetitive assessment of knowledge that had been learned and was tested on a unit basis in the past in order to achieve deep learning. Further, students of all school years considered that post-test explanatory lectures by teachers were necessary. Conclusions: East Asian students' perceptions indicated that, in addition to their intensive memorization within narrow test domains compartmentalized by end-of-unit tests, the concept of PT was suitable for repetitive memorization, as it helped them to integrate their knowledge and to increase their understanding. Post-test explanatory lectures might lessen their dislike of the intangible goals of PT, but at the expense of delaying the development of self-directed learning. Key issues for the optimization of PT in East Asia may include administration of PT after completed end-of-unit tests and a gradual change in feedback methodology over school years from test-oriented post-test lectures to the provision of literature references only, as a means of enhancing test self-review and self-directed learning.
  • Terada S, Matsuyama Y, Onoda K, Kawai K
    Nihon Shokakibyo Gakkai zasshi = The Japanese journal of gastro-enterology 9 111 (9) 1782 - 1788 1349-7693 2014/09 [Refereed][Not invited]
  • Akihito Maruyama, Takao Nagashima, Kohei Ikenoya, Yoko Aoki, Yasushi Matsuyama, Masahiro Iwamoto, Seiji Minota
    INTERNAL MEDICINE 52 (16) 1833 - 1837 0918-2918 2013 [Refereed][Not invited]
    We herein report the findings of 2 cases of normotensive scleroderma renal crisis (SRC) that developed soon after the commencement of a glucocorticoid therapy. We also review 8 cases of normotensive SRC reported in Japan, including our cases. The common characteristics of these 8 cases are as follows: the recent onset of systemic sclerosis, the presence of diffuse skin sclerosis, the presence of myositis and/or serositis, a high titer of antinuclear antibody and positivity for anti-Scl-70 antibody. In 7 of the 8 patients, thrombotic microangiopathy developed within one month of starting the glucocorticoid treatment. We should be careful with the use of glucocorticoids in systemic sclerosis patients exhibiting these features in order to avoid cases of normotensive SRC.
  • 自治医科大学におけるマルチメディアadvanced CBT形式の記述式(SEQ)総合判定試験の導入
    松山 泰, 岡崎 仁昭, 岸 浩一郎, 坂東 政司, 矢野 晴美, 川上 忠孝, 武藤 弘行, 佐田 尚宏
    医学教育 (一社)日本医学教育学会 43 (Suppl.) 136 - 136 0386-9644 2012/07
  • Yasushi Matsuyama, Hitoaki Okazaki, Motoaki Hoshino, Sachiko Onishi, Yasuyuki Kamata, Katsuya Nagatani, Takao Nagashima, Masahiro Iwamoto, Taku Yoshio, Hiromi Ohto-Ozaki, Hiroyuki Tamemoto, Mayumi Komine, Hitoshi Sekiya, Shin-ichi Tominaga, Seiji Minota
    RHEUMATOLOGY INTERNATIONAL 5 32 (5) 1397 - 1401 0172-8172 2012/05 [Refereed][Not invited]
    Although TNF inhibitors have dramatically improved the outcome of patients with rheumatoid arthritis, 30-40% of patients do not respond well to them and treatment needs to be changed. In an effort to discriminate good and poor responders, we focused on the change in serum and synovial fluid levels of interleukin (IL-) 33 before and after treatment with TNF inhibitors. They were also measured in synovial fluids from 17 TNF inhibitor-na < ve patients, and fibroblast-like synoviocytes (FLS) in-culture from 6 patients and correlated with various pro-inflammatory cytokines. Serum levels of IL-33 at 6 months after treatment decreased significantly in responders, while they did not change in non-responders. Synovial fluid levels of IL-33 in 6 patients under treatment with TNF inhibitors stayed high in 3 who were refractory and slightly elevated in 2 moderate responders, while they were undetectable in one patient under remission. Among inflammatory cytokines measured in 17 synovial fluids from TNF inhibitor-na < ve patients, levels of IL-33 showed a significant positive correlation only to those of IL-1 beta. IL-1 beta increased IL-33 expression markedly in FLS in vitro, compared to TNF-alpha. IL-1 beta might be inducing RA inflammation through producing pro-inflammatory IL-33 in TNF inhibitor-hypo-responders. Sustained elevation of serum and/or synovial levels of IL-33 may account for a poor response to TNF inhibitors, although how TNF inhibitors affect the level of IL-33 remains to be elucidated.
  • Koji Wakatabi, Mayumi Komine, Jitlada Meephansan, Yasushi Matsuyama, Hidetoshi Tsuda, Shin-ichi Tominaga, Mamitaro Ohtsuki
    EUROPEAN JOURNAL OF DERMATOLOGY 22 (3) 333 - 336 1167-1122 2012/05 [Refereed][Not invited]
    Soluble ST2 (sST2) is a soluble form of the transmembrane receptor for interleukin (IL)-33, ST2L, and is a member of the IL-1 receptor family. sST2 antagonizes IL-33-ST2L signaling by competing with ST2L as a decoy receptor for IL-33. We investigated the sST2 and IL-33 levels in the sera and bullous fluid of bullous pemphigoid patients and compared these with the corresponding levels in normal healthy controls. As controls, we used the bullous fluid of burn patients and that from suction blisters induced in normal healthy volunteers. The serum sST2 concentrations of bullous pemphigoid patients were higher than those of healthy controls. Serum sST2 levels correlated with the area of skin involvement and serum lactate dehydrogenase levels, suggesting that serum sST2 levels reflect disease severity. The sST2 concentrations in bullous fluid from bullous pemphigoid patients were higher than those from controls. The concentration of IL-33 ligand was below the detectable limits in all enzyme-linked immunosorbent assay samples. Thus, our study suggested that the serum sST2 level may be a useful marker of disease severity and that sST2 functions as a negative regulator in the pathophysiology of bullous pemphigoid.
  • 関節リウマチの難治病態におけるIL-33/ST2Lシステムの役割
    松山 泰
    自治医科大学紀要 (学)自治医科大学 34 172 - 172 1881-252X 2012/03 [Not refereed][Not invited]
  • Yasushi Matsuyama, Takao Nagashima, Kyoko Honne, Yasuyuki Kamata, Masahiro Iwamoto, Hitoaki Okazaki, Kazuya Sato, Keiya Ozawa, Seiji Minota
    INTERNAL MEDICINE 6 50 (6) 639 - 642 0918-2918 2011 [Refereed][Not invited]
    A 63-year-old woman receiving tumor necrosis factor (TNF) inhibitors for rheumatoid arthritis (RA) was found to have smoldering IgA-kappa type multiple myeloma (MM). Retrospective examination of stored serum samples revealed a steady increase of serum IgA levels after the start of TNF inhibitor therapy. The patient's articular symptoms showed marked exacerbation when TNF inhibitors were discontinued because of fear of worsening the MM. Tocilizumab improved RA symptoms dramatically and stabilized serum IgA levels for 13 months after a transient steep rise. This case suggests that tocilizumab can be used safely in patients with inflammatory disorders with coexisting MM.
  • Hiromi Ohto-Ozaki, Kenji Kuroiwa, Naoko Mato, Yasushi Matsuyama, Morisada Hayakawa, Hiroyuki Tamemoto, Shin-ichi Tominaga
    EUROPEAN JOURNAL OF IMMUNOLOGY 40 (9) 2632 - 2642 0014-2980 2010/09 [Refereed][Not invited]
    IL-33, a member of the IL-1 family, activates MAPK and NF-kappa B through its receptor ST2L and IL-1RAcP. ST2, a member of the IL-1R superfamily, is a secreted form of ST2 gene products, which has been shown to act as a decoy receptor for IL-33 and to inhibit the IL-33/ST2L/IL-1RAcP signaling pathway. In this work, we generated ST2 transgenic mice. In control mice, intraperitoneal administration of IL-33 caused an increased number of eosinophils in blood and in peritoneal cavity, an increased number of peritoneal M Phi, splenomegaly, accumulation of periodic acid-Schiff-positive material in the lung, and high concentrations of serum IL-5 and IL-13. However, these alterations were hardly detectable in ST2 Tg mice. In peritoneal M Phi from IL-33-stimulated mice, mRNA expression of M2 M Phi marker genes were increased compared with thioglycollate-elicited peritoneal M Phi. The IL-33-stimulation also increased the secretion of IL-6 from M Phi. However, when the IL-33 was preincubated with ST2 prior to its addition to the M Phi cultures, the secretion of IL-6 was attenuated. These data suggest that, though IL-33 induced the Th2-type immune responses and infiltration of M2 type M Phi into the peritoneal cavity, ST2 can downregulate these reactions both in vivo and in vitro.
  • 【「分子標的薬」時代へ 投与のコツと副反応のコントロール】 高分子の分子標的薬の話題 抗体治療薬を中心に インフリキシマブによる乾癬性紅皮症/関節炎の治療
    松山 泰, 簑田 清次, 大槻 マミ太郎
    Visual Dermatology (株)学研メディカル秀潤社 9 (8) 820 - 822 2186-6589 2010/07 [Not refereed][Not invited]
  • Yasushi Matsuyama, Takao Nagashima, Tomokazu Masuda, Masahiro Iwamoto, Taku Yoshio, Hitoaki Okazaki, Mamitaro Ohtsuki, Seiji Minota
    Jichi Medical University journal 自治医科大学 32 63 - 69 1881-252X 2010/03 [Not refereed][Not invited]
  • Yasushi Matsuyama, Hitoaki Okazaki, Hiroyuki Tamemoto, Hirotaka Kimura, Yasuyuki Kamata, Katsuya Nagatani, Takao Nagashima, Morisada Hayakawa, Masahiro Iwamoto, Taku Yoshio, Shin-Ichi Tominaga, Seiji Minota
    JOURNAL OF RHEUMATOLOGY 37 (1) 18 - 25 0315-162X 2010/01 [Refereed][Not invited]
    Objective. To determine levels of interleukin 33 (IL-33) in serum and synovial fluid (SF) and their clinical associations in patients with rheumatoid arthritis (RA). To evaluate the ability of activated peripheral blood mononuclear cells (PBMC) and fibroblast-like synoviocytes (FLS) from RA patients to release IL-33. Methods. Sera were obtained from 59 patients with RA, 10 patients with infectious diseases, and 42 healthy volunteers. SF samples were obtained from 15 patients with RA and 13 with osteoarthritis. IL-33 levels were measured using a sandwich ELISA after removal of rheumatoid factor with protein A-Sepharose beads. FLS were stimulated with IL-1 beta and tumor necrosis factor, and treated with or without chemical damage. PBMC were stimulated with anti-CD3/CD28 antibodies. The levels of IL-33 were measured in the culture supernatants and cell lysates by ELISA or immunoblotting. Results. Serum IL-33 levels were significantly higher in RA patients, especially in the high disease activity group compared to the moderate or low activity group. IL-33 levels in SF were elevated in all 15 RA patients measured. IL-33 levels were higher in SF samples than in sera in 7 RA patients measured simultaneously. The 30-kDa IL-33 precursor was detected in the culture supernatants of damaged FLS but was not detected in those of activated PBMC and non-damaged FLS. Conclusion. IL-33 levels were elevated in sera and SF samples from patients with RA, and correlated with disease activity. IL-33 was produced mainly in inflamed joints; IL-33/ST2L signaling might play an important role in joint inflammation of human RA. (First Release Nov 15 2009; J Rheumatol 2010;37;18-25; doi:10.3899/jrheum.090492)
  • Morisada Hayakawa, Hiroko Hayakawa, Yasushi Matsuyama, Hiroyuki Tamemoto, Hitoaki Okazaki, Shin-ichi Tominaga
    BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS 387 (1) 218 - 222 0006-291X 2009/09 [Refereed][Not invited]
    Interleukin (IL)-33 is a novel member of the IL-1 family. IL-33 is primarily synthesized as a 30-kDa precursor (pro-IL-33). Pro-IL-33 is cleaved by caspase-1 into an 18-kDa mature form (mature IL-33) in vitro. Recombinant mature IL-33 has been known to induce T-helper type-2 (Th2)-associated cytokines and inflammatory cytokines via its receptor, ST2L However, processing of pro-IL-33 in vivo has not been clarified yet. Here, we report that calpain mediates pro-IL-33 processing in vivo. Pro-IL-33 was expressed by stimulating human epithelial cells with phorbol 12-myristate 13-acetate. Calcium ionophore induced pro-IL-33 cleavage and mature IL-33 production. This cleavage was inhibited by treatment with a calcium and calpain inhibitors. Moreover, short interfering RNA-mediated knockdown of calpains chelator suppressed pro-IL-33 cleavage. These results indicate that calpains play a critical role in pro-IL-33 processing in vivo. (C) 2009 Elsevier Inc. All rights reserved.
  • プロテアソーム阻害薬によるループスモデルマウスの治療
    松山 泰, 岡崎 仁昭
    リウマチ科 (有)科学評論社 42 (2) 190 - 197 0915-227X 2009/08 [Not refereed][Not invited]
  • Ken Futaki, Mayumi Komine, Satomi Hosoda, Miho Hirashima, Hideto Yokokura, Tomoko Yamada, Satoru Murata, Yasushi Matsuyama, Takao Nagashima, Hiroyuki Nara, Seiji Minota, Mamitaro Ohtsuki
    EUROPEAN JOURNAL OF DERMATOLOGY 19 (3) 266 - 267 1167-1122 2009/05 [Refereed][Not invited]
  • 【膠原病診療のブレークスルー 早期診断・早期治療のポイント】 膠原病の難治性病態の早期診断・早期治療のこつ 吸収不全症候群
    松山 泰, 岩本 雅弘
    内科 (株)南江堂 101 (4) 724 - 727 0022-1961 2008/04 [Not refereed][Not invited]
    強皮症では消化管への膠原線維の沈着、腸内細菌の過剰増殖などにより、著しい消化吸収不全を呈することがある。在宅中心静脈栄養にいたる症例も存在する。吸収不全症候群の診断として、Sudan III染色による便中の脂肪測定が行われる。蠕動障害の早期発見には、Sitzmarksが有用と考えられる。根本的な治療法はないが、対症療法に加え、十分な栄養管理を行う。早期に介入することにより、腸内細菌の過剰増殖や腸液貯留による二次的な粘膜障害を抑制することが期待できる。不可逆的に進行していく疾患であるため、患者のほか、家族や介護協力者との連携をとりながら診療に取り組む。(著者抄録)
  • 【強皮症の病態とそのマネージメント】 強皮症におけるpseudo-obstructionの診断と治療
    松山 泰, 岡崎 仁昭
    リウマチ科 (有)科学評論社 39 (4) 312 - 316 0915-227X 2008/04 [Not refereed][Not invited]
  • 肺病変を伴って再発した結節性多発動脈炎の1例
    松山 泰, 豊嶋 幹生, 千田 金吾, 須田 隆文
    日本胸部臨床 克誠堂出版(株) 65 (5) 484 - 488 0385-3667 2006/05 [Not refereed][Not invited]
  • Ganciclovir投与が必要であったサイトメガロウイルスによる伝染性単核球症の1例
    松山 泰, 豊嶋 幹生, 千田 金吾, 須田 隆文
    内科 (株)南江堂 96 (4) 783 - 785 0022-1961 2005/10 [Not refereed][Not invited]
  • アスピリン喘息における副鼻腔気管支外病変
    豊嶋 幹生, 千田 金吾, 松山 泰, 佐藤 潤, 須田 隆文, 早川 啓史
    アレルギーの臨床 (株)北隆館 25 (11) 897 - 901 0285-6379 2005/10 [Not refereed][Not invited]
    アスピリン喘息(AIA)では,好酸球性胃腸炎,好酸球性中耳炎,好酸球性肺炎などの全身病変(副鼻腔気管支外病変)を合併しやすいことが報告されている.当院通院中AIA 11例中5例に副鼻腔気管支外病変(好酸球性胃腸炎3例,好酸球性中耳炎2例,好酸球性肺炎1例,1例は好酸球性胃腸炎と好酸球性中耳炎の両者を合併)の合併を認めた.これらの全身病変は,高用量吸入ステロイド薬やロイコトリエン受容体拮抗薬による喘息症状改善および全身ステロイド薬離脱後に末梢血好酸球増加を伴って発症することが多く,短期間のステロイド薬投与により改善した.AIAに伴う好酸球性胃腸炎は,他の原因(食物アレルギーなど)による好酸球性胃腸炎と比較して上部消化管症状(心窩部痛,腹満感,嘔吐など)を主症状とし,症状の改善に短期間のステロイド薬投与が必要であった.全身病変(副鼻腔気管支外病変)を合併しやすいことが,全身疾患としてのAIAの特徴的臨床像であり,AIAの病因・病態を解明していく上での1つの重要な着眼点であると考えられる(著者抄録)
  • 高用量HFA-BDP投与中の気管支喘息患者に発症した慢性好酸球性肺炎の1例
    豊嶋 幹生, 千田 金吾, 松山 泰, 須田 隆文
    日本胸部臨床 克誠堂出版(株) 64 (6) 567 - 571 0385-3667 2005/06 [Not refereed][Not invited]
  • 血栓除去のみで救命しえた96歳・上腸間膜動脈塞栓症の1例
    綿引 洋一, 西山 雷祐, 金井 俊和, 阿部 仁郎, 松山 泰, 原 竜平
    手術 金原出版(株) 58 (13) 2209 - 2212 0037-4423 2004/12 [Not refereed][Not invited]

Books etc

  • 子どもと大人の主体的・自律的な学びを支える実践
    松山泰 (Contributor第11章 プロフェッショナルの学びーー医療領域からの提案)
    福村出版 2021/09
  • 医学部教育における自己調整学習力の育成ー専門職アイデンティティ形成からの視座
    松山泰 (Single work)
    福村出版 2021/08
  • 指導医のための医学教育学 実践と科学の往復
    松山泰 (ContributorChapter 12 ちゃんとした試験をすれば授業は要らない?;Chapter 18 Entrustable Professional Activity─“信頼して任せられる”とは何か?)
    京都大学学術出版会 2020/08
  • 国試・改訂コアカリ対応 地域医療学入門
    松山泰 (Contributor医療に関連した人文・社会科学領域)
    診断と治療社 2019/08
  • 自己調整学習の多様な展開 バリー・ジマーマンへのオマージュ
    松山泰 (Joint translation第14章 慢性疾患管理における自己調整介入の使用)
    福村出版 2019/04
  • 日常診療の中で学ぶプロフェッショナリズム
    松山泰 (Joint translation第10章 プロフェッショナリズムを評価する)
    カイ書林 2018/07

Conference Activities & Talks

  • Model lessons for instructors of physiology  [Invited]
    Yasushi Matsuyama
    99th annual meeting, the Physiological Society of Japan  2022/03
  • 松山泰
    第13回全国シンポジウム「地域推薦枠医学生の卒前・卒後教育をどうするか?」  2022/02
  • 評価学のパラダイムシフト 大学院教育への展開  [Invited]
    令和3年度 北海道医療大学リハビリテーション科学部FD  2022/01
  • 学修者評価  [Invited]
    愛知医大 医学教育者のためのワークショップ  2021/12
  • ウィズ・ポストコロナ時代の 学修者評価のパラダイムシフト  [Invited]
    香川大学医学部FD  2021/11
  • With/Postコロナ時代の 保健学実習・講義の在り方  [Invited]
    九州大学大学院医学研究院保健学部門FD  2021/09
  • Ideals and realities of CBT/Web-based exam: Experience in creating a CBT model for the National Examination for Medical Practitioners  [Invited]
    Yasushi Matsuyama
    126th Annual Meeting of The Japanese Association of Anatomists/ 98th Annual Meeting of The Physiological Society of Japan  2021/03
  • ポストコロナ時代を考えた学生評価について  [Invited]
    第25回京都大学医学教育ワークショップ  2020/12
  • 新時代の医療系教育 ~職業アイデンティティを刺激する~  [Invited]
    令和2年度昭和大学ビギナーズ・ワークショップ  2020/08
  • ポストコロナ時代を考えた学生評価について  [Invited]
    医学教育サイバーシンポジウム  2020/06
  • 新しい統合試験の作り方 〜プログレステストとマルチメディアの活用〜  [Invited]
    旭川医大教育センター FD・授業評価部門主催 FD講演会  2019/11
  • Hypothesis-driven physical examination  [Invited]
    Yasushi Matsuyama, Ryuichi Ohta, Akiteru Takamura
    Collaborative Project to Increase Production of Rural Doctors (CPIRD) 2019  2019/11
  • Problem-based and problem-oriented learning  [Invited]
    Akiteru Takamura, Ryuichi Ohta, Yasushi Matsuyama
    Collaborative Project to Increase Production of Rural Doctors (CPIRD) 2019  2019/11
  • Reflection;professional identity formation  [Invited]
    Hironobu Fujiwara, Yasushi Matsuyama
    Collaborative Project to Increase Production of Rural Doctors (CPIRD) 2019  2019/11
  • 生涯学習力としての自己調整学習力を伸ばす  [Invited]
    第72回医学教育セミナーとワークショップ  2019/05
  • Cinemed applying "Rashomon approach to teaching"  [Invited]
    Sayaka Oikawa, Yasushi Matsuyama
    Collaborative Project to Increase Production of Rural Doctors (CPIRD) 2018  2018/11
  • Problem-based and problem-oriented learning  [Invited]
    Sayaka Oikawa, Yasushi Matsuyama
    Collaborative Project to Increase Production of Rural Doctors (CPIRD) 2018  2018/11
  • Does changing from teacher-centered to learner-centered contexts develop self-regulated learning? A qualitative study in a medical university in Japan.  [Not invited]
    Matsuyama, Y, Nakaya, M, Okazaki, H, Leppink, J, van der Vleuten, C
    Association for Medical Education in Europe (AMEE) Annual Conference 2018  2018/08
  • Contextual professional challenges promote or hinder self-regulated learning: a qualitative study contrasting rural physicians with undergraduates in Japan.  [Not invited]
    Matsuyama, Y, Nakaya, M, Okazaki, H, Leppink, J, van der Vleuten, C
    15th Asia Pacific Medical Education Conference (APMEC)  2018/01
  • Cinemed applying "Rashomon approach to teaching"  [Invited]
    Sayaka Oikawa, Yasushi Matsuyama
    Collaborative Project to Increase Production of Rural Doctors (CPIRD) 2017  2017/11
  • Problem-based and problem-oriented learning  [Invited]
    Sayaka Oikawa, Yasushi Matsuyama
    Collaborative Project to Increase Production of Rural Doctors (CPIRD) 2017  2017/11
  • Peer-assisted learning in a teacher-centered education culture – a survey of traditional learning communities, Kenjinkai.  [Not invited]
    Otani, M, Matsuyama, Y, Heta, K, Okazaki, H
    Association for Medical Education in Europe (AMEE) Annual Conference 2017  2017/08
  • Self-directness and international scope among participants in the Free Course Student Doctor system.  [Not invited]
    Matsuyama, Y, Okazaki, H, Kario, K, Noda, Y
    The 14th Asia Pacific Medical Education Conference (APMEC)  2017/01
  • Entrustable Professional Activity  [Invited]
    Yasushi Matsuyama, Hiroshi Nishigori
    Collaborative Project to Increase Production of Rural Doctors (CPIRD) 2016  2016/11
  • Problem-based learning  [Invited]
    Sayaka Oikawa, Yasushi Matsuyama
    Collaborative Project to Increase Production of Rural Doctors (CPIRD) 2016  2016/11
  • PCC OSCEのステーション変更による影響の評価  [Not invited]
    石川 鎮清, 江口 和男, 松山 泰, 岡崎 仁昭
    医学教育  2016/07
  • 自治医科大学フリーコース・スチューデントドクター制度による自発性の促進と国際的視野の涵養  [Not invited]
    松山 泰, 岡崎 仁昭, 苅尾 七臣, 野田 泰子
    医学教育  2016/07
  • 自治医科大学におけるマルチメディア形式総合判定試験の6年の解析  [Not invited]
    松山 泰, 三重野 牧子, 武藤 弘行, 江口 和男, 石川 鎮清, 佐田 尚宏, 岡崎 仁昭
    医学教育  2015/07
  • 東アジア地域初のプログレステストの試み  [Not invited]
    松山 泰, 菊川 誠, 村上 礼子, Muijtjens Arno, Stalmeijer Renee, 石川 鎮清, 岡崎 仁昭
    医学教育  2015/07
  • 都道府県拠点病院実習とそのファカルティ・ディベロプメント  [Not invited]
    石川 鎮清, 江口 和男, 松山 泰, 武藤 弘行, 岡崎 仁昭
    医学教育  2015/07
  • 自治医科大学医学部初年次における学生成績の推移に関する分析  [Not invited]
    三重野 牧子, 武藤 弘行, 浜本 敏郎, 松山 泰, 岡崎 仁昭, 松儀 実広, 野田 泰子, 佐田 尚宏, 簑田 清次, 遠藤 仁司
    医学教育  2015/07
  • A first trial of progress testing in East Asia: students' perceptions of the new testing procedure.  [Not invited]
    Matsuyama Y, Muijtjens AM, Kikukawa M, Stalmeijer R, Murakami R, Ishikawa S, Okazaki H
    AMEE 2015  2015
  • 自治医科大学におけるマルチメディア形式の総合判定試験の導入  [Not invited]
    松山 泰, 石川 鎮清, 岸 浩一郎, 矢野 晴美, 武藤 弘行, 佐田 尚宏, 岡崎 仁昭
    医学教育  2014/07
  • 自治医科大学におけるマルチメディアadvanced CBT形式の記述式(SEQ)総合判定試験の導入  [Not invited]
    松山 泰, 岡崎 仁昭, 岸 浩一郎, 坂東 政司, 矢野 晴美, 川上 忠孝, 武藤 弘行, 佐田 尚宏
    医学教育  2012/07
  • アミロイドーシスの病型診断に未固定生検試料のイムノブロットが有用である  [Not invited]
    山田 俊幸, 松山 泰, 寺井 千尋, 星井 嘉信
    臨床化学  2012/07
  • 自治医科大学におけるマルチメディアadvanced CBT形式の記述式(SEQ)総合判定試験の導入  [Not invited]
    松山 泰, 岡崎 仁昭, 岸 浩一郎, 河野 正樹, 金井 信行, 黒木 茂広, 坂東 政司, 矢野 晴美, 川上 忠孝, 武藤 弘行, 佐田 尚宏
    医学教育  2011/07
  • アトピー性皮膚炎における血清中IL-33および可溶性ST2濃度の検討  [Not invited]
    遠田 博, 唐川 大, 小宮根 真弓, 塚原 理恵子, 津田 英利, 村田 哲, 大槻 マミ太郎, 松山 泰, 富永 眞一
    Journal of Environmental Dermatology and Cutaneous Allergology  2011/07
  • くすぶり型骨髄腫(IgA-κ型)合併関節リウマチにトシリズマブを使用し、有効性と安全性が確認された一例  [Not invited]
    松山 泰, 長嶋 孝夫, 本根 杏子, 釜田 康行, 岩本 雅弘, 岡崎 仁昭, 簑田 清次, 佐藤 一也, 小澤 敬也
    関東リウマチ  2011/03 
    症例は63歳女性で、45歳時加齢性黄斑変性症、47歳より関節リウマチ(RA)、53歳時高血圧症の既往があった。約10ヵ月前、DAS 28-CRP 5.1とRAの疾患活動性が高くなり紹介受診した。インフリキシマブの効果が次第に減弱し、エタネルセプトに変更でDAS 28-CRP 2.8まで改善した。その後、定期検査でIgA-κ型のM蛋白を認め、骨髄穿刺で10%の形質細胞浸潤を認めてくすぶり型骨髄腫と診断し、SASPに変更するもRAの悪化で離床困難となり入院とした。両上下肢左右対称性に関節腫脹、圧痛、尿検査で蛋白(1+)、血算で軽度貧血、赤沈亢進、生化学で総蛋白高値(M蛋白分画高値、γ分画低値)、血清学でCRP、SAA、IgAの上昇を認め、抗CCP抗体陽性であった。右手X線で手根骨、MCP・PIP関節の破壊・強直を認め、MRIでパンヌスによる骨侵食を認めた。トシリズマブ開始で腫脹関節数、疼痛関節数は著しく減少し、M蛋白の増加は認めず、投与開始11ヵ月以上にわたり有害事象なく継続できている。
  • 血清中および滑液中のIL-33の持続的な上昇は抗TNF療法に対する関節リウマチの低反応と関連する(Sustained elevation of interleukin-33 in serum and synovial fluid is associated with a poor response of rheumatoid arthritis to anti-tumor necrosis factor therapy)  [Not invited]
    松山 泰, 岡崎 仁昭, 星野 東明, 大西 佐知子, 尾崎 裕美, 為本 浩至, 富永 眞一, 簑田 清次
    日本生化学会大会・日本分子生物学会年会合同大会講演要旨集  2010/12
  • 分泌型ST2は、IL-33投与によるマウス腹腔マクロファージのM2化を抑制する(Soluble ST2 attenuated the IL-33-induced M2 polarization of peritoneal macrophages)  [Not invited]
    尾崎 裕美, 黒岩 憲二, 松山 泰, 早川 盛禎, 為本 浩至, 富永 眞一
    日本生化学会大会・日本分子生物学会年会合同大会講演要旨集  2010/12
  • RAの病因・病態 リウマチ血清および関節液でのIL-33測定系の確立と疾患活動性との相関  [Not invited]
    松山 泰, 岡崎 仁昭, 木村 洋貴, 永谷 勝也, 釜田 康行, 長嶋 孝夫, 岩本 雅弘, 吉尾 卓, 簑田 清次
    日本リウマチ学会総会・学術集会・国際リウマチシンポジウムプログラム・抄録集  2010/03
  • 大動脈炎症候群が発見された壊疽性膿皮症の1例  [Not invited]
    二木 賢, 細田 里美, 平嶋 海帆, 横倉 英人, 山田 朋子, 村田 哲, 大槻 マミ太郎, 松山 泰, 長嶋 孝夫, 簑田 清次
    日本皮膚科学会雑誌  2008/09
  • 松山 泰, 岡崎 仁昭, 木村 洋貴, 長嶋 孝夫, 簑田 清次
    アレルギー  2008/04
  • 肺病変を伴って再発した結節性多発動脈炎の1例  [Not invited]
    松山 泰, 豊嶋 幹生, 千田 金吾, 須田 隆文
    アレルギー  2005/09
  • Sjogren症候群に伴う胸膜炎の1例  [Not invited]
    松山 泰, 豊嶋 幹生, 岡崎 仁昭, 蓑田 清次
    中部リウマチ  2005/08
  • 診断に血清MMP-3が有用であった高齢者の膝関節炎の2例  [Not invited]
    松山 泰, 岡崎 仁昭, 簑田 清次
    日本リウマチ学会総会・学術集会・国際リウマチシンポジウムプログラム・抄録集  2005/04
  • 上腸間膜動脈急性閉塞症の早期診断治療 1例報告および血行再建4例の検討  [Not invited]
    綿引 洋一, 西山 雷祐, 金井 俊和, 阿部 仁郎, 松山 泰
    日赤医学  2004/09
  • 好酸球性胃腸炎の臨床的検討 アスピリン喘息合併例と非合併例の比較  [Not invited]
    豊嶋 幹生, 千田 金吾, 松山 泰, 須田 隆文
    アレルギー  2004/09
  • 肺胞出血を合併した強皮症に伴う間質性肺炎の1例  [Not invited]
    豊嶋 幹生, 千田 金吾, 松山 泰, 中村 祐太郎, 妹川 史朗, 須田 隆文
    アレルギー  2004/03
  • 気管支喘息における血清チミジンキナーゼ活性の検討 アスピリン喘息の病因と関連して  [Not invited]
    豊嶋 幹生, 千田 金吾, 松山 泰, 須田 隆文
    アレルギー  2003/09


  • フルオンライン開催による医学教育専門家制度履修コースの分析
    松山 泰, 田川 まさみ, 高村 昭輝, 西屋 克己, 淺田 義和, 村岡 千種, 伊藤 彰一, 守屋 利佳, 清水 郁夫, 鈴木 康之, 藤崎 和彦, 日本医学教育学会医学教育専門家委員会  医学教育  52-  (Suppl.)  104  -104  2021/07
  • コロナ禍における外科臨床実習での医学生の意識変容調査報告
    川平 洋, 鈴木 義彦, 前田 佳孝, 淺田 義和, 倉科 憲太郎, 原尾 美智子, 遠藤 和洋, 笹沼 英紀, 鯉沼 広治, 山口 博紀, 佐久間 康成, 堀江 久永, 細谷 好則, 味村 俊樹, 北山 丈二, アラン・レフォー, 松山 泰, 佐田 尚宏  医学教育  52-  (Suppl.)  107  -107  2021/07
  • Problem-based learningにおいて社会的相互依存をもたらす文脈的特性の探索
    清水 郁夫, 松山 泰, Duvivier Robbert, Van Der Vleuten Cees  医学教育  52-  (Suppl.)  110  -110  2021/07
  • COVID-19流行下におけるフリーコースステューデントドクター学生の学習経験
    中西 愛結, 松山 泰, 大森 司  医学教育  52-  (Suppl.)  115  -115  2021/07
  • ニッポンの医学教育部門 組織的コンフィギュレーションの視点から
    西城 卓也, 清水 郁夫, 淺田 義和, 恒川 幸司, 早川 佳穂, 川上 ちひろ, 今福 輪太郎, 松山 泰  医学教育  52-  (Suppl.)  120  -120  2021/07
  • COVID-19対応としてのMoodleを用いた教育支援の報告
    淺田 義和, 松山 泰, 松村 正巳, 岡崎 仁昭  医学教育  52-  (Suppl.)  150  -150  2021/07
  • ICTを活用したシームレス医学教育コンテンツの開発 河北班からの報告
    松山 泰, 淺田 義和  医学教育  52-  (Suppl.)  233  -233  2021/07
  • 多発性筋炎・皮膚筋炎:抗MDA-5抗体 抗MDA-5抗体陽性皮膚筋炎3例における血清IP-10の推移
    石澤 彩子, 中村 潤, 島 菜月, 矢澤 宏晃, 齊藤 圭介, 近藤 春香, 柳田 真衣, 松山 泰, 釜田 康行, 佐藤 浩二郎  日本リウマチ学会総会・学術集会プログラム・抄録集  65回-  392  -392  2021/03
  • 動画・音声付臨床教材のつくりかた
    松山 泰, 淺田 義和, 岡崎 仁昭, 石川 鎮清, 川平 洋  新しい医学教育の流れ  20-  (3)  S130  -S140  2021/01
  • 鈴木 真紀, 松山 泰, 淺田 義和, 三重野 牧子, 川平 洋, 武藤 弘行, 石川 鎮清, 岡崎 仁昭  医学教育  51-  (Suppl.)  215  -215  2020/07
  • 自治医科大学におけるマルチメディア形式総合判定試験の6年の解析
    松山 泰, 三重野 牧子, 武藤 弘行, 江口 和男, 石川 鎮清, 佐田 尚宏, 岡崎 仁昭  医学教育  46-  (Suppl.)  133  -133  2015/07  [Not refereed][Not invited]
  • 都道府県拠点病院実習とそのファカルティ・ディベロプメント
    石川 鎮清, 江口 和男, 松山 泰, 武藤 弘行, 岡崎 仁昭  医学教育  46-  (Suppl.)  204  -204  2015/07  [Not refereed][Not invited]
  • 自治医科大学におけるマルチメディア形式の総合判定試験の導入
    松山 泰, 石川 鎮清, 岸 浩一郎, 矢野 晴美, 武藤 弘行, 佐田 尚宏, 岡崎 仁昭  医学教育  45-  (Suppl.)  141  -141  2014/07  [Not refereed][Not invited]
  • 松山 泰, 岡崎 仁昭, 長嶋 孝夫, 岩本 雅弘, 吉尾 卓, 簑田 清次  アレルギー  57-  (9)  2008/10  [Not refereed][Not invited]
  • 松山 泰, 岡崎 仁昭, 木村 洋貴, 長嶋 孝夫, 簑田 清次  アレルギー  57-  (3)  2008/04  [Not refereed][Not invited]

Awards & Honors

  • 2022/01 The Asia Pacific Scholar MOST ACCESSED ARTICLE AWARD 2021
     Professional identity formation-oriented mentoring technique as a method to improve self-regulated learning: A mixed-method study 
    受賞者: Yasushi Matsuyama;Hitoaki Okazaki;Kazuhiko Kotani;Yoshikazu Asada;Shizukiyo Ishikawa;Adam Jon Lebowitz;Jimmie Leppink;Cees van der Vleuten
  • 2022/01 The Asia Pacific Scholar BEST ARTICLE AWARD 2021
     Professional identity formation-oriented mentoring technique as a method to improve self-regulated learning: A mixed-method study 
    受賞者: Yasushi Matsuyama;Hitoaki Okazaki;Kazuhiko Kotani;Yoshikazu Asada;Shizukiyo Ishikawa;Adam Jon Lebowitz;Jimmie Leppink;Cees van der Vleuten
  • 2018/08 Japan Medical Education Foundation/Japan Society for Medical Education Kaketa Award
    受賞者: Yasushi Matsuyama
  • 2010/05 Japanese Society of Allergology The 22th Spring Meeting of Japanese Society of Allergology Poster Award
    受賞者: Yasushi Matsuyama

Research Grants & Projects

  • 厚生労働省:厚生労働科学研究費補助金
    Date (from‐to) : 2021/04 -2024/03 
    Author : 河北博文, 伴信太郎, 岡崎仁昭, 松山泰, 淺田義和, 川平洋
  • 職業アイデンティティ形成志向型PBLによる自己調整学習力の向上
    Japan Society for the Promotion of Science:Grants-in-Aid for Scientific Research Grant-in-Aid for Scientific Research (C)
    Date (from‐to) : 2020/04 -2024/03 
    Author : 松山 泰, 淺田 義和, 岡崎 仁昭, 清水 郁夫, 田中 淳一
  • 卒前・卒後のコンピテンシー獲得に至る多様なプロセスを支援する多面的な評価情報が集約化されたダイナミックシラバスの開発とその効果検証に関する研究
    厚生労働省 政策科学総合研究事業(臨床研究等ICT基盤構築・人工知能実装研究事業):
    Date (from‐to) : 2018/11 -2021/03 
    Author : 岡崎仁昭
  • 科学研究費 基盤研究(C)
    Date (from‐to) : 2017 -2020 
    Author : 松山泰
  • 「日本発」自己調整学習力の確立支援プログラムの開発
    公益財団法人 医学教育振興財団:医学教育研究助成
    Date (from‐to) : 2017 -2019 
    Author : 松山泰
  • 関節リウマチにおけるカルパイン切断型インターロイキン33の役割
    科学研究費 若手研究(B)
    Date (from‐to) : 2010 -2011 
    Author : 松山泰

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