Researchers Database

hishida erika

    InternalMedicineNephrology Assistant Professor
Last Updated :2022/05/19

Researcher Information

J-Global ID

Research Areas

  • Life sciences / Nephrology

Academic & Professional Experience

  • 2021/01  自治医科大学内科学講座 腎臓内科学部門学内講師
  • 2019/04 - 2020/01  Jichi Medical University内科学講座腎臓内科学部門病院助教
  • 2013/04 - 2014/03  Jichi Medical University内科学講座後期研修医
  • 2011/04 - 2013/03  Jichi Medical University初期研修医


  • 2014/04 - 2019/03  Jichi Medical University  大学院  医学研究科

Association Memberships


Published Papers

  • Erika Hishida, Takahisa Kobayashi, Yuko Ono, Kentaro Oka, Takahiro Masuda, Yoshihiko Ueda, Tetsu Akimoto, Osamu Saito, Daisuke Nagata
    CEN case reports 11 (1) 36 - 42 2022/02 
    Isolated tubulointerstitial nephritis (TIN) without glomerular crescent formation is a rare manifestation of antineutrophil cytoplasmic antibody (ANCA)-associated vasculitis (AAV). Some patients with monoclonal gammopathy of undetermined significance present with renal complications due to serum monoclonal protein. Here, we present a case of TIN presumably attributable to AAV with monoclonal gammopathy. Laboratory data revealed acute kidney injury, elevated C-reactive protein (CRP) and ANCA titers, and elevated tubular injury markers. Renal biopsy revealed TIN with no apparent glomerular lesion. The findings of peritubular capillaritis and tubulitis indicated that AAV had contributed to the development of TIN. However, in situ hybridization for free light chains revealed kappa light chain restriction, indicating that the involvement of monoclonal gammopathy in the pathogenesis of TIN remains possible. The patient also developed ophthalmic neuropathy, probably caused by AAV. Oral prednisone (0.6 mg/kg/day) administration improved both the ocular symptoms and the laboratory parameters. Our case demonstrated that the concurrence of AAV and monoclonal gammopathy could pose a diagnostic dilemma in distinguishing the cause of TIN. Besides, some reports suggest an association between AAV and monoclonal gammopathy, although direct evidence is lacking. Further research is needed to establish this association.
  • Homare Ito, Hiroaki Kimura, Tadayoshi Karasawa, Shu Hisata, Ai Sadatomo, Yoshiyuki Inoue, Naoya Yamada, Emi Aizawa, Erika Hishida, Ryo Kamata, Takanori Komada, Sachiko Watanabe, Tadashi Kasahara, Takuji Suzuki, Hisanaga Horie, Joji Kitayama, Naohiro Sata, Kazuyo Yamaji-Kegan, Masafumi Takahashi
    Journal of immunology (Baltimore, Md. : 1950) 205 (5) 1393 - 1405 2020/09 [Refereed][Not invited]
    Intestinal ischemia/reperfusion (I/R) injury is a life-threatening complication that leads to inflammation and remote organ damage. The NLRP3 inflammasome regulates the caspase-1-dependent release of IL-1β, an early mediator of inflammation after I/R injury. In this study, we investigated the role of the NLRP3 inflammasome in mice with intestinal I/R injury. Deficiency of NLRP3, ASC, caspase-1/11, or IL-1β prolonged survival after intestinal I/R injury, but neither NLRP3 nor caspase-1/11 deficiency affected intestinal inflammation. Intestinal I/R injury caused acute lung injury (ALI) characterized by inflammation, reactive oxygen species generation, and vascular permeability, which was markedly improved by NLRP3 deficiency. Bone marrow chimeric experiments showed that NLRP3 in non-bone marrow-derived cells was the main contributor to development of intestinal I/R-induced ALI. The NLRP3 inflammasome in lung vascular endothelial cells is thought to be important to lung vascular permeability. Using mass spectrometry, we identified intestinal I/R-derived lipid mediators that enhanced NLRP3 inflammasome activation in lung vascular endothelial cells. Finally, we confirmed that serum levels of these lipid mediators were elevated in patients with intestinal ischemia. To our knowledge, these findings provide new insights into the mechanism underlying intestinal I/R-induced ALI and suggest that endothelial NLRP3 inflammasome-driven IL-1β is a novel potential target for treating and preventing this disorder.
  • Emi Aizawa, Tadayoshi Karasawa, Sachiko Watanabe, Takanori Komada, Hiroaki Kimura, Ryo Kamata, Homare Ito, Erika Hishida, Naoya Yamada, Tadashi Kasahara, Yoshiyuki Mori, Masafumi Takahashi
    iScience 23 (5) 101070 - 101070 2020/05 [Refereed][Not invited]
    Pyroptosis is a form of regulated cell death that is characterized by gasdermin processing and increased membrane permeability. Caspase-1 and caspase-11 have been considered to be essential for gasdermin D processing associated with inflammasome activation. In the present study, we found that NLRP3 inflammasome activation induces delayed necrotic cell death via ASC in caspase-1/11-deficient macrophages. Furthermore, ASC-mediated caspase-8 activation and subsequent gasdermin E processing are necessary for caspase-1-independent necrotic cell death. We define this necrotic cell death as incomplete pyroptosis because IL-1β release, a key feature of pyroptosis, is absent, whereas IL-1α release is induced. Notably, unprocessed pro-IL-1β forms a molecular complex to be retained inside pyroptotic cells. Moreover, incomplete pyroptosis accompanied by IL-1α release is observed under the pharmacological inhibition of caspase-1 with VX765. These findings suggest that caspase-1 inhibition during NLRP3 inflammasome activation modulates forms of cell death and permits the release of IL-1α from dying cells.
  • Daisuke Nagata, Erika Hishida, Takahiro Masuda
    International journal of nephrology and renovascular disease 13 171 - 178 2020 [Refereed][Not invited]
    When renal function declines, blood pressure rises, which in turn causes the kidneys to deteriorate. In order to stop this vicious cycle, it is necessary to lower the blood pressure to a "moderate" level in patients who have chronic kidney disease (CKD)-associated hypertension. Such optimization is problematic, since tight control of blood pressure might worsen the prognosis in elderly patients with CKD, especially those with advanced arteriosclerosis. Although renin-angiotensin system (RAS) inhibitors, angiotensinogen converting enzyme (ACE) inhibitors and angiotensin II receptor blockers (ARBs) are first-line drugs for hypertensive patients with diabetes, they should be used with caution depending on the patients' conditions. Recently, there has been a focus on the preventive effects of sodium-glucose cotransporter 2 (SGLT2) inhibitors, anti-diabetic drugs that have been shown to have an impact, on heart and kidney complications. SGLT2 inhibitors increase the amount of sodium chloride delivered to the macular densa of the distal tubules and correct glomerular hyperfiltration by contraction of afferent arterioles via the tubule-glomerular feedback system. It might be one of the reasons why SGLT2 inhibitors show the renal- and cardio-protective effects; however, the mechanism behind their function remains to be elucidated.
  • Homare Ito, Ai Sadatomo, Yoshiyuki Inoue, Naoya Yamada, Emi Aizawa, Erika Hishida, Ryo Kamata, Tadayoshi Karasawa, Hiroaki Kimura, Sachiko Watanabe, Takanori Komada, Hisanaga Horie, Joji Kitayama, Naohiro Sata, Masafumi Takahashi
    Biochemical and biophysical research communications 519 (1) 15 - 22 0006-291X 2019/10 [Refereed][Not invited]
    BACKGROUND: Intestinal ischemia/reperfusion (I/R) injury is a life-threatening complication that leads to inflammation and remote organ damage. However, the underlying mechanism is not yet fully understood. Toll-like receptor 5 (TLR5) is highly expressed in mucosa and recognizes flagellin, the main component of the bacterial flagella. Here, we investigated the role of TLR5 in inflammation and tissue damage after intestinal I/R injury using TLR5-deficient mice. METHODS AND RESULTS: Intestinal levels of TLR5 mRNA and flagellin protein were elevated in wild-type mice subjected to intestinal I/R. Although TLR5 deficiency had no effect on intestinal flagellin levels, it significantly attenuated intestinal injury and inflammatory responses after intestinal I/R. TLR5 deficiency also markedly improved survival in mice after intestinal I/R injury. In wild-type mice, intestinal I/R injury induced remote organ damage, particularly in the lung, which was attenuated by TLR5 deficiency. Furthermore, TLR5 deficiency prevented lung inflammatory responses and vascular permeability after intestinal I/R injury. CONCLUSION: These findings demonstrate a novel role of TLR5 and provide new insights into the mechanism underlying inflammation and tissue damage after intestinal I/R injury.
  • Erika Hishida, Homare Ito, Takanori Komada, Tadayoshi Karasawa, Hiroaki Kimura, Sachiko Watanabe, Ryo Kamata, Emi Aizawa, Tadashi Kasahara, Yoshiyuki Morishita, Tetsu Akimoto, Daisuke Nagata, Masafumi Takahashi
    Scientific reports 9 (1) 10363 - 10363 2019/07 [Refereed][Not invited]
    Long-term peritoneal dialysis (PD) therapy leads to peritoneal inflammation and fibrosis. However, the mechanism underlying PD-related peritoneal inflammation and fibrosis remains unclear. NLRP3 inflammasome regulates the caspase-1-dependent release of interleukin-1β and mediates inflammation in various diseases. Here, we investigated the role of NLRP3 inflammasome in a murine model of PD-related peritoneal fibrosis induced by methylglyoxal (MGO). Inflammasome-related proteins were upregulated in the peritoneum of MGO-treated mice. MGO induced parietal and visceral peritoneal fibrosis in wild-type mice, which was significantly reduced in mice deficient in NLRP3, ASC, and interleukin-1β (IL-1β). ASC deficiency reduced the expression of inflammatory cytokines and fibrotic factors, and the infiltration of macrophages. However, myeloid cell-specific ASC deficiency failed to inhibit MGO-induced peritoneal fibrosis. MGO caused hemorrhagic ascites, fibrin deposition, and plasminogen activator inhibitor-1 upregulation, but all of these manifestations were inhibited by ASC deficiency. Furthermore, in vitro experiments showed that MGO induced cell death via the generation of reactive oxygen species in vascular endothelial cells, which was inhibited by ASC deficiency. Our results showed that endothelial NLRP3 inflammasome contributes to PD-related peritoneal inflammation and fibrosis, and provide new insights into the mechanisms underlying the pathogenesis of this disorder.
  • Takuya Murakami, Tetsu Akimoto, Mari Okada, Erika Hishida, Taro Sugase, Atsushi Miki, Marina Kohara, Hiromichi Yoshizawa, Takahiro Masuda, Takahisa Kobayashi, Osamu Saito, Shigeaki Muto, Daisuke Nagata
    Drug target insights 12 1177392818782899 - 1177392818782899 2018 [Refereed][Not invited]
    A 66-year-old women with no history of renal disease was admitted due to a coma and acute kidney injury with a serum creatinine level of 7.44 mg/dL which were ascribed to valacyclovir neurotoxicity and nephrotoxicity, respectively. She had received valacyclovir at a standard dosage for the treatment of herpes zoster and was finally discharged, having fully returned to her normal baseline mental status with a recovered serum creatinine level of 0.68 mg/dL. We feel that awareness of this pathology remains a challenge for physicians and therefore strongly recommend the further accumulation of experiences similar to our own. Our experience underscores the pitfalls of administering valacyclovir to elderly patients who barely appear to have a favorable renal function. Several concerns regarding the therapeutic management, including blood purification strategies, that emerged in this case are also discussed.
  • Mari Okada, Tetsu Akimoto, Mutsumi Kawamata, Toshimi Imai, Erika Hishida, Marina Kohara, Atsushi Miki, Takuya Murakami, Taro Sugase, Takahiro Masuda, Yuko Ono, Yoshihiko Ueda, Osamu Saito, Shigeaki Muto, Daisuke Nagata
    Clinical medicine insights. Case reports 10 1179547617723317 - 1179547617723317 1179-5476 2017 [Refereed][Not invited]
    The association between nephrotic syndrome (NS) and a hypercoagulable state has been demonstrated. Controlling the blood clotting activity may therefore be attractive for patients with nephrosis in terms of thromboembolism prophylaxis. We herein report a 75-year-old woman with minimal change disease who developed pains in the right back, groin, and thigh because of retroperitoneal bleeding during prophylactic anticoagulation with unfractionated heparin. Although this procedure has not been accepted as the standard of care for patients with nephrosis, pharmacologic prophylaxis may already be practiced empirically, as in the present patient. We believe that our experience highlights the pitfalls of such a management in patients with nephrosis, implying the need for a diagnostic strategy for identifying those patients with NS who can benefit from prophylactic anticoagulation. Several concerns that emerged in this case are also discussed.
  • Marina Kohara, Shin-ichi Takeda, Takuya Miki, Ken Ohara, Yuko Yamanaka, Mutsumi Kawamata, Erika Hishida, Natsuko Wakabayashi, Tomoyuki Yamazaki, Masaru Ichida, Tetsu Akimoto, Shigeaki Muto, Daisuke Nagata
    Internal medicine (Tokyo, Japan) 55 (8) 955 - 9 0918-2918 2016 [Refereed][Not invited]
    Uremic patients may have a variety of organ involvement, however, the precise causality may be impossible to determine in some cases because the symptoms of uremia are also associated with other diseases. With an emphasis on the elusive nature of uremia, we herein describe a 53-year-old man with preexisting renal impairment who developed acute pericarditis with deterioration of his renal function. Hemodialysis was immediately initiated on the presumption of uremia, however, articular symptoms emerged approximately a month later and led to a final diagnosis of rheumatoid arthritis, followed by successful withdrawal of hemodialysis.
  • Erika Hishida, Takahiro Masuda, Tetsu Akimoto, Ryuta Sato, Natsuko Wakabayashi, Atsushi Miki, Naoko Otani, Toshimi Imai, Taro Sugase, Shin-Ichi Takeda, Shigeaki Muto, Daisuke Nagata
    Internal medicine (Tokyo, Japan) 55 (14) 1893 - 8 0918-2918 2016 [Refereed][Not invited]
    We herein present a case of relapsed sarcoidosis with a deteriorated renal function accompanied by hypercalcemia, nephrolithiasis, and a ureteral stone in a woman with a history of ocular sarcoidosis. The ocular involvement appeared to be well controlled for a long period of time with a topical ophthalmic steroid; however, we believe that the absence of apparent recrudescence could have led to the delay in our diagnosis of relapse of the disease during the follow-up period. The conundrums regarding longitudinal surveillance for both evaluating the disease activity and determining the necessity of therapeutics are also discussed.

Books etc

  • 腎臓論文ベストセレクション
  • 腎臓内科グリーンノート
  • 透析療法グリーンノート
  • 腎臓専門医のためのCKD診療Q&A


  • 腹膜線維症におけるインフラマソームの役割の解明
    菱田 英里華  自治医科大学紀要  42-  66  -66  2020/03  [Not refereed][Not invited]
  • アルポート症候群を合併したIgA腎症に扁摘パルス療法が奏功した一症例
    常松 大帆, 村上 琢哉, 岡 健太郎, 金子 美和, 平田 真美, 三浦 麻里菜, 菱田 英里華, 三木 敦史, 小森 さと子, 伊澤 佐世子, 吉澤 寛道, 菅生 太朗, 小林 高久, 武田 真一, 小野 祐子, 秋元 哲, 斎藤 修, 長田 太助  日本腎臓学会誌  61-  (6)  741  -741  2019/08  [Not refereed][Not invited]
  • 腹膜線維症におけるNLRP3インフラマソームの役割
    菱田 英里華, 駒田 敬則, 秋元 哲, 高橋 将文, 長田 太助  日本腎臓学会誌  61-  (3)  301  -301  2019/05  [Not refereed][Not invited]
  • 腹膜線維症におけるインフラマソームの関与についての検討
    菱田 英里華, 駒田 敬則, 秋元 哲, 高橋 将文, 長田 太助  日本透析医学会雑誌  52-  (Suppl.1)  547  -547  2019/05  [Not refereed][Not invited]
  • 末期腎不全患者に対する長時間血液透析が及ぼす骨代謝マーカー変化についての検討
    村上 琢哉, 齋藤 修, 朝倉 伸司, 小池 かおり, 菱田 英里華, 増田 貴博, 前嶋 明人, 秋元 哲, 長田 太助  日本透析医学会雑誌  52-  (Suppl.1)  652  -652  2019/05  [Not refereed][Not invited]
  • 劇症1型糖尿病発症に際し横紋筋融解症と心筋障害を併発した1例
    齋藤 新介, 高橋 学, 村上 明子, 五十嵐 真由子, 石山 祐介, 菱田 英里華, 永島 秀一, 岡田 健太, 海老原 健, 石橋 俊  糖尿病  61-  (9)  631  -631  2018/09  [Not refereed][Not invited]
  • ECUMによる除水が細胞内・外水分量に及ぼす効果 血液透析との比較検討
    秋山 裕輝, 増田 貴博, 杉江 舜, 松岡 諒, 大舘 孝幸, 中川 早紀, 菱田 英里華, 五十嵐 祐介, 小林 高久, 齋藤 修, 長田 太助  日本透析医学会雑誌  51-  (Suppl.1)  458  -458  2018/05  [Not refereed][Not invited]
  • 腹膜透析における腹膜機能と細胞外マトリックスの再構築
    平原 一郎, 草野 英二, 菱田 英里華, 今井 利美, 大西 央, 森下 義幸, 井上 真, 秋元 哲, 斎藤 修, 武藤 重明, 長田 太助  腎と透析  83-  (別冊 腹膜透析2017)  203  -205  2017/11  [Not refereed][Not invited]
    当院のPD患者32例を対象に、細胞外マトリックの再構築に関わる3つの因子(排液中のMMP-2、Fibulin-1、Tenascin C)と腹膜機能との関連性について検討した。結果、3因子とも平均値は腹膜機能(D/Pcre値)と有意な相関を示した。32例中、被嚢性腹膜硬化症の1例では3因子の値が全患者の中で最も高かった。Fibulin-1は腹膜組織の再構築を介して腹膜機能を反映する可能性が示唆され、新たな腹膜劣化マーカーになりうると考えられた。MMP-2は3因子の中で腹膜機能との相関性が最も高かったことから、優れた腹膜劣化マーカーであると考えられた。
  • 人工血管感染を繰り返す透析患者に併発した粟粒結核の1例
    菱田 英里華, 増田 貴博, 小林 高久, 武田 真一, 秋元 哲, 齋藤 修, 武藤 重明, 長田 太助  栃木県医学会々誌  47-  104  -106  2017/06  [Not refereed][Not invited]
  • 中川早紀, 小林高久, 村上琢哉, 茗荷宏昭, 三木敦史, 菱田英里華, 武島えり, 伊澤佐世子, 吉澤寛道, 増田貴博, 秋元哲, 齋藤修, 武藤重明, 長田太助  日本透析医学会雑誌  50-  (Suppl.1)  696  -696  2017/05  [Not refereed][Not invited]
  • 岡田麻里, 増田貴博, 三木敦史, 菱田英里華, 小原麻里菜, 村上琢哉, 山崎智行, 三木拓哉, 菅生太朗, 渡邉裕子, 小林高久, 秋元哲, 齋藤修, 武藤重明, 長田太助  日本高血圧学会総会プログラム・抄録集  39回-  359  -359  2016/09  [Not refereed][Not invited]
  • 茗荷宏昭, 三木敦史, 増田貴博, 菱田英里華, 吉澤寛道, 小林高久, 秋元哲, 齋藤修, 武藤重明, 長田太助  日本腎臓学会誌  58-  (6)  769  -769  2016/08  [Not refereed][Not invited]
  • 人工血管感染を繰り返す透析患者に併発した粟粒結核の1例
    菱田 英里華, 増田 貴博, 山崎 智行, 菅生 太朗, 武島 えり, 五十嵐 祐介, 伊澤 佐世子, 黒澤 明, 南木 浩二, 小林 高久, 武田 真一, 秋元 哲, 八木澤 隆, 齋藤 修, 武藤 重明, 長田 太助  日本透析医学会雑誌  49-  (Suppl.1)  475  -475  2016/05  [Not refereed][Not invited]
  • アマンタジン中毒に対し血液吸着(DHP)と血液濾過透析(HDF)併用が有効であった1症例
    山崎 智行, 小林 高久, 三木 敦史, 岡田 麻里, 小原 麻里菜, 菱田 英里華, 中川 早紀, 小森 さと子, 吉澤 寛道, 小藤田 篤, 増田 貴博, 秋元 哲, 斉藤 修, 武藤 重明, 長田 太助  日本透析医学会雑誌  49-  (Suppl.1)  906  -906  2016/05  [Not refereed][Not invited]
  • 人工血管感染を繰り返す透析患者に併発した粟粒結核の1例
    菱田 英里華, 増田 貴博, 山崎 智行, 菅生 太朗, 武島 えり, 五十嵐 祐介, 伊澤 佐世子, 黒澤 明, 南木 浩二, 小林 高久, 武田 真一, 秋元 哲, 八木澤 隆, 齋藤 修, 武藤 重明, 長田 太助  日本透析医学会雑誌  49-  (Suppl.1)  475  -475  2016/05  [Not refereed][Not invited]
  • アマンタジン中毒に対し血液吸着(DHP)と血液濾過透析(HDF)併用が有効であった1症例
    山崎 智行, 小林 高久, 三木 敦史, 岡田 麻里, 小原 麻里菜, 菱田 英里華, 中川 早紀, 小森 さと子, 吉澤 寛道, 小藤田 篤, 増田 貴博, 秋元 哲, 斉藤 修, 武藤 重明, 長田 太助  日本透析医学会雑誌  49-  (Suppl.1)  906  -906  2016/05  [Not refereed][Not invited]
  • 可逆性後頭葉白質脳症(PRES)を併発した末期腎不全の1例
    若林 奈津子, 三木 拓哉, 小原 麻里菜, 菱田 英里華, 中川 早紀, 武島 えり, 菅生 太朗, 小林 高久, 秋元 哲, 斉藤 修, 武藤 重明, 長田 太助  日本腎臓学会誌  57-  (6)  960  -960  2015/08  [Not refereed][Not invited]
  • 特発性肺線維症(IPF)、肺アスペルギローマ(PA)の診断7年後にMPO-ANCA型急速進行性糸球体腎炎(RPGN)を発症した1例
    菱田 英里華, 小林 高久, 菅生 太朗, 三木 敦史, 大谷 尚子, 今井 利美, 増田 貴博, 岩津 好隆, 武田 真一, 山本 尚史, 秋元 哲, 石原島 繁彦, 武藤 重明, 長田 太助  日本腎臓学会誌  57-  (6)  969  -969  2015/08  [Not refereed][Not invited]
  • 生体腎移植の約40年後に腹膜透析を再開した末期腎不全の1例
    菱田 英里華, 小林 高久, 菅生 太郎, 今井 利美, 若林 奈津子, 吉澤 寛道, 岡田 麻里, 山本 尚史, 武田 真一, 木村 貴明, 八木澤 隆, 武藤 重明, 長田 太助  日本透析医学会雑誌  48-  (Suppl.1)  929  -929  2015/05  [Not refereed][Not invited]
  • 腎外サルコイドーシス症診断10年後に高Ca血症を伴った尿細管間質性腎炎と尿路結石症を発症した一例
    菱田 英里華, 増田 貴博, 佐藤 隆太, 池田 奈津子, 三木 敦史, 木村 貴明, 谷澤 志帆, 秋元 哲, 八木澤 隆, 長田 太助  日本腎臓学会誌  56-  (6)  844  -844  2014/08  [Not refereed][Not invited]
  • 嚢胞内感染の治療中に胸腔内穿破を来した多発性嚢胞腎(PKD)・透析患者の1例
    武田 真一, 佐藤 隆太, 増田 貴博, 菱田 英里華, 伊藤 千春, 竹本 文美, 安藤 康宏, 武藤 重明, 長田 太助  日本透析医学会雑誌  47-  (Suppl.1)  564  -564  2014/05  [Not refereed][Not invited]
  • 菱田 英里華, 永島 秀一, 野牛 宏晃, 奈良 藍子, 寺岡 祥子, 長坂 昌一郎, 大須賀 淳一, 石橋 俊  日本内分泌学会雑誌  87-  (3)  972  -972  2011/12  [Not refereed][Not invited]

Awards & Honors

  • 2019/06 日本腎臓学会学術総会 優秀演題賞
  • 2018/09 Jichi Medical University Best Presentation Award
     4th JMU Workshop for Graduate Students
  • 2018 Jichi Medical University Graduate Student Research Award
  • 2017 Jichi Medical University Graduate Student Start-up Award
  • 2016/04 医学生・研修医の日本内科学会ことはじめ2016 優秀指導医賞

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