koshimizu takaaki

FacultyDivisionofMolecularPharmacology
Job titleAssociate ProfessorWeb site

Profile

Research Keywords

    Molecular therapeutics, Receptor, Opioid

Research Areas

  • Basic medicine / General pharmacology

Academic Societies

  • THE JAPAN NEUROENDOCRINE SOCIETY
  • THE JANPANESE SOCIETY OF INTERNAL MEDICINE
  • JAPANESE CIRCULATION SOCIETY
  • JAPANESE COLLEGE OF CARDIOLOGY
  • Japanese Pharmaceutical society
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Academic Societiesclose
  • THE JAPAN NEUROENDOCRINE SOCIETY
  • THE JANPANESE SOCIETY OF INTERNAL MEDICINE
  • JAPANESE CIRCULATION SOCIETY
  • JAPANESE COLLEGE OF CARDIOLOGY
  • Japanese Pharmaceutical society

Research Activities

Papers(paper)

  • Pharmacological lineage analysis revealed the binding affinity of broad-spectrum substance P antagonists to receptors for gonadotropin-releasing peptide.
    Arai K, Kashiwazaki A, Fujiwara Y, Tsuchiya H, Sakai N, Shibata K, Koshimizu TA
    European journal of pharmacology 749 98-106 Feb. 2015
  • Voluntary locomotion linked with cerebral activation is mediated by vasopressin V1a receptors in free-moving mice.
    Masuki S, Sumiyoshi E, Koshimizu TA, Qian J, Higuchi K, Tsujimoto G, Nose H
    The Journal of physiology 591 3651-3665 Jul. 2013
  • α-Lipoic acid protects against arsenic trioxide-induced acute QT prolongation in anesthetized guinea pigs.
    Kumazaki M, Ando H, Kakei M, Ushijima K, Taniguchi Y, Yoshida M, Yamato S, Washino S, Koshimizu TA, Fujimura A
    European journal of pharmacology 705 1-10 Apr. 2013
  • Metastasis-associated protein, S100A4 mediates cardiac fibrosis potentially through the modulation of p53 in cardiac fibroblasts.
    Tamaki Y, Iwanaga Y, Niizuma S, Kawashima T, Kato T, Inuzuka Y, Horie T, Morooka H, Takase T, Akahashi Y, Kobuke K, Ono K, Shioi T, Sheikh SP, Ambartsumian N, Lukanidin E, Koshimizu TA, Miyazaki S, Kimura T
    Journal of molecular and cellular cardiology 57 72-81 Apr. 2013
  • Serum amyloid A upsurge precedes standard biomarkers of hepatotoxicity in ritodrine-injected mice.
    Tsuchiya H, Sato J, Tsuda H, Fujiwara Y, Yamada T, Fujimura A, Koshimizu TA
    Toxicology 305 79-88 Mar. 2013
  • Vasopressin V1a and V1b receptors: from molecules to physiological systems.
    Koshimizu TA, Nakamura K, Egashira N, Hiroyama M, Nonoguchi H, Tanoue A
    Physiological reviews 92 1813-1864 Oct. 2012
  • Chronic ritodrine treatment induces refractoriness of glucose-lowering β2 adrenoceptor signal in female mice.
    Tsuchiya H, Ushijima K, Fujiwara Y, Fujimura A, Koshimizu TA
    Regulatory toxicology and pharmacology : RTP 62 561-567 Apr. 2012
  • Dysfunction of lipid sensor GPR120 leads to obesity in both mouse and human.
    Ichimura A, Hirasawa A, Poulain-Godefroy O, Bonnefond A, Hara T, Yengo L, Kimura I, Leloire A, Liu N, Iida K, Choquet H, Besnard P, Lecoeur C, Vivequin S, Ayukawa K, Takeuchi M, Ozawa K, Tauber M, Maffeis C, Morandi A, Buzzetti R, Elliott P, Pouta A, Jarvelin MR, Körner A, Kiess W, Pigeyre M, Caiazzo R, Van Hul W, Van Gaal L, Horber F, Balkau B, Lévy-Marchal C, Rouskas K, Kouvatsi A, Hebebrand J, Hinney A, Scherag A, Pattou F, Meyre D, Koshimizu TA, Wolowczuk I, Tsujimoto G, Froguel P
    Nature 483 350-354 Feb. 2012
  • The roles of V1a vasopressin receptors in blood pressure homeostasis: a review of studies on V1a receptor knockout mice.
    Fujiwara Y, Tanoue A, Tsujimoto G, Koshimizu TA
    Clinical and experimental nephrology Nov. 2011
  • Proximal tubules and podocytes are toxicity targets of bucillamine in a mouse model of drug-induced kidney injury.
    Fujiwara Y, Tsuchiya H, Sakai N, Shibata K, Fujimura A, Koshimizu TA
    European journal of pharmacology 670(1) 208-215 Nov. 2011
Display all
Papers(paper)close
  • Pharmacological lineage analysis revealed the binding affinity of broad-spectrum substance P antagonists to receptors for gonadotropin-releasing peptide.
    Arai K, Kashiwazaki A, Fujiwara Y, Tsuchiya H, Sakai N, Shibata K, Koshimizu TA
    European journal of pharmacology 749 98-106 Feb. 2015
  • Voluntary locomotion linked with cerebral activation is mediated by vasopressin V1a receptors in free-moving mice.
    Masuki S, Sumiyoshi E, Koshimizu TA, Qian J, Higuchi K, Tsujimoto G, Nose H
    The Journal of physiology 591 3651-3665 Jul. 2013
  • α-Lipoic acid protects against arsenic trioxide-induced acute QT prolongation in anesthetized guinea pigs.
    Kumazaki M, Ando H, Kakei M, Ushijima K, Taniguchi Y, Yoshida M, Yamato S, Washino S, Koshimizu TA, Fujimura A
    European journal of pharmacology 705 1-10 Apr. 2013
  • Metastasis-associated protein, S100A4 mediates cardiac fibrosis potentially through the modulation of p53 in cardiac fibroblasts.
    Tamaki Y, Iwanaga Y, Niizuma S, Kawashima T, Kato T, Inuzuka Y, Horie T, Morooka H, Takase T, Akahashi Y, Kobuke K, Ono K, Shioi T, Sheikh SP, Ambartsumian N, Lukanidin E, Koshimizu TA, Miyazaki S, Kimura T
    Journal of molecular and cellular cardiology 57 72-81 Apr. 2013
  • Serum amyloid A upsurge precedes standard biomarkers of hepatotoxicity in ritodrine-injected mice.
    Tsuchiya H, Sato J, Tsuda H, Fujiwara Y, Yamada T, Fujimura A, Koshimizu TA
    Toxicology 305 79-88 Mar. 2013
  • Vasopressin V1a and V1b receptors: from molecules to physiological systems.
    Koshimizu TA, Nakamura K, Egashira N, Hiroyama M, Nonoguchi H, Tanoue A
    Physiological reviews 92 1813-1864 Oct. 2012
  • Chronic ritodrine treatment induces refractoriness of glucose-lowering β2 adrenoceptor signal in female mice.
    Tsuchiya H, Ushijima K, Fujiwara Y, Fujimura A, Koshimizu TA
    Regulatory toxicology and pharmacology : RTP 62 561-567 Apr. 2012
  • Dysfunction of lipid sensor GPR120 leads to obesity in both mouse and human.
    Ichimura A, Hirasawa A, Poulain-Godefroy O, Bonnefond A, Hara T, Yengo L, Kimura I, Leloire A, Liu N, Iida K, Choquet H, Besnard P, Lecoeur C, Vivequin S, Ayukawa K, Takeuchi M, Ozawa K, Tauber M, Maffeis C, Morandi A, Buzzetti R, Elliott P, Pouta A, Jarvelin MR, Körner A, Kiess W, Pigeyre M, Caiazzo R, Van Hul W, Van Gaal L, Horber F, Balkau B, Lévy-Marchal C, Rouskas K, Kouvatsi A, Hebebrand J, Hinney A, Scherag A, Pattou F, Meyre D, Koshimizu TA, Wolowczuk I, Tsujimoto G, Froguel P
    Nature 483 350-354 Feb. 2012
  • The roles of V1a vasopressin receptors in blood pressure homeostasis: a review of studies on V1a receptor knockout mice.
    Fujiwara Y, Tanoue A, Tsujimoto G, Koshimizu TA
    Clinical and experimental nephrology Nov. 2011
  • Proximal tubules and podocytes are toxicity targets of bucillamine in a mouse model of drug-induced kidney injury.
    Fujiwara Y, Tsuchiya H, Sakai N, Shibata K, Fujimura A, Koshimizu TA
    European journal of pharmacology 670(1) 208-215 Nov. 2011
  • Protective effect of α-lipoic acid against arsenic trioxide-induced acute cardiac toxicity in rats.
    Kumazaki M, Ando H, Sasaki A, Koshimizu TA, Ushijima K, Hosohata K, Oshima Y, Fujimura A
    Journal of pharmacological sciences 115 244-248 2011
  • Oxytocin stimulates expression of a noncoding RNA tumor marker in a human neuroblastoma cell line.
    Koshimizu TA, Fujiwara Y, Sakai N, Shibata K, Tsuchiya H
    Life sciences 86(11-12) 455-460 Mar. 2010
  • Inhibition of heat shock protein 90 attenuates adenylate cyclase sensitization after chronic morphine treatment.
    Koshimizu TA, Tsuchiya H, Tsuda H, Fujiwara Y, Shibata K, Hirasawa A, Tsujimoto G, Fujimura A
    Biochemical and biophysical research communications 392(4) 603-607 Feb. 2010
  • Signaling by purinergic receptors and channels in the pituitary gland.
    Stojilkovic SS, He ML, Koshimizu TA, Balik A, Zemkova H
    Molecular and cellular endocrinology 314(2) 184-191 Jan. 2010
  • Vasopressin regulation of blood pressure and volume: findings from V1a receptor-deficient mice.
    Aoyagi T, Koshimizu TA, Tanoue A
    Kidney international 76 1035-1039 Nov. 2009
  • Prostate growth inhibition by subtype-selective alpha(1)-adrenoceptor antagonist naftopidil in benign prostatic hyperplasia.
    Kojima Y, Sasaki S, Oda N, Koshimizu TA, Hayashi Y, Kiniwa M, Tsujimoto G, Kohri K
    The Prostate 69 1521-1528 Oct. 2009
  • Novel selective ligands for free fatty acid receptors GPR120 and GPR40.
    Hara T, Hirasawa A, Sun Q, Sadakane K, Itsubo C, Iga T, Adachi T, Koshimizu TA, Hashimoto T, Asakawa Y, Tsujimoto G
    Naunyn-Schmiedeberg's archives of pharmacology 380 247-255 Sep. 2009
  • Cranberry juice suppressed the diclofenac metabolism by human liver microsomes, but not in healthy human subjects.
    Ushijima K, Tsuruoka S, Tsuda H, Hasegawa G, Obi Y, Kaneda T, Takahashi M, Maekawa T, Sasaki T, Koshimizu TA, Fujimura A
    British journal of clinical pharmacology 68 194-200 Aug. 2009
  • New topics in vasopressin receptors and approach to novel drugs: vasopressin and pain perception.
    Koshimizu TA, Tsujimoto G
    Journal of pharmacological sciences 109(1) 33-37 Jan. 2009
  • Flow cytometry-based binding assay for GPR40 (FFAR1; free fatty acid receptor 1).
    Hara T, Hirasawa A, Sun Q, Koshimizu TA, Itsubo C, Sadakane K, Awaji T, Tsujimoto G
    Molecular pharmacology 75 85-91 Jan. 2009
  • Cloning and characterization of the rat free fatty acid receptor GPR120: in vivo effect of the natural ligand on GLP-1 secretion and proliferation of pancreatic beta cells.
    Tanaka T, Yano T, Adachi T, Koshimizu TA, Hirasawa A, Tsujimoto G
    Naunyn-Schmiedeberg's archives of pharmacology 377 515-522 Jun. 2008
  • Free fatty acids induce cholecystokinin secretion through GPR120.
    Tanaka T, Katsuma S, Adachi T, Koshimizu TA, Hirasawa A, Tsujimoto G
    Naunyn-Schmiedeberg's archives of pharmacology 377 523-527 Jun. 2008
  • Production and characterization of a monoclonal antibody against GPR40 (FFAR1; free fatty acid receptor 1).
    Hirasawa A, Itsubo C, Sadakane K, Hara T, Shinagawa S, Koga H, Nose H, Koshimizu TA, Tsujimoto G
    Biochemical and biophysical research communications 365(1) 22-28 Jan. 2008
  • Clinical implications from studies of alpha1 adrenergic receptor knockout mice.
    Koshimizu TA, Tanoue A, Tsujimoto G
    Biochemical pharmacology 73 1107-1112 Apr. 2007
  • Glucocorticoid-induced granzyme A expression can be used as a marker of glucocorticoid sensitivity for acute lymphoblastic leukemia therapy.
    Myoumoto A, Nakatani K, Koshimizu TA, Matsubara H, Adachi S, Tsujimoto G
    Journal of human genetics 52(4) 328-333 2007
  • Functional role of spliced cytoplasmic tails in P2X2-receptor-mediated cellular signaling.
    Koshimizu TA, Tsujimoto G
    Journal of pharmacological sciences 101(4) 261-266 Aug. 2006
  • V1a vasopressin receptors maintain normal blood pressure by regulating circulating blood volume and baroreflex sensitivity.
    Koshimizu TA, Nasa Y, Tanoue A, Oikawa R, Kawahara Y, Kiyono Y, Adachi T, Tanaka T, Kuwaki T, Mori T, Takeo S, Okamura H, Tsujimoto G
    Proceedings of the National Academy of Sciences of the United States of America 103(20) 7807-7812 May 2006
  • Carboxyl-terminal splicing enhances physical interactions between the cytoplasmic tails of purinergic P2X receptors.
    Koshimizu TA, Kretschmannova K, He ML, Ueno S, Tanoue A, Yanagihara N, Stojilkovic SS, Tsujimoto G
    Molecular pharmacology 69 1588-1598 May 2006
  • Free fatty acids administered into the colon promote the secretion of glucagon-like peptide-1 and insulin.
    Adachi T, Tanaka T, Takemoto K, Koshimizu TA, Hirasawa A, Tsujimoto G
    Biochemical and biophysical research communications 340 332-337 Feb. 2006
  • Correlation between vasoconstrictor roles and mRNA expression of alpha1-adrenoceptor subtypes in blood vessels of genetically engineered mice.
    Hosoda C, Tanoue A, Shibano M, Tanaka Y, Hiroyama M, Koshimizu TA, Cotecchia S, Kitamura T, Tsujimoto G, Koike K
    British journal of pharmacology 146 456-466 Oct. 2005
  • Molecular dissection of purinergic P2X receptor channels.
    Stojilkovic SS, Tomic M, He ML, Yan Z, Koshimizu TA, Zemkova H
    Annals of the New York Academy of Sciences 1048 116-130 Jun. 2005
  • Inhibition of protein kinase CK2 prevents the progression of glomerulonephritis.
    Yamada M, Katsuma S, Adachi T, Hirasawa A, Shiojima S, Kadowaki T, Okuno Y, Koshimizu TA, Fujii S, Sekiya Y, Miyamoto Y, Tamura M, Yumura W, Nihei H, Kobayashi M, Tsujimoto G
    Proceedings of the National Academy of Sciences of the United States of America 102(21) 7736-7741 May 2005
  • Two alpha1-adrenergic receptor subtypes regulating the vasopressor response have differential roles in blood pressure regulation.
    Hosoda C, Koshimizu TA, Tanoue A, Nasa Y, Oikawa R, Tomabechi T, Fukuda S, Shinoura H, Oshikawa S, Takeo S, Kitamura T, Cotecchia S, Tsujimoto G
    Molecular pharmacology 67 912-922 Mar. 2005
  • Carvedilol selectively inhibits oscillatory intracellular calcium changes evoked by human alpha1D- and alpha1B-adrenergic receptors.
    Koshimizu TA, Tsujimoto G, Hirasawa A, Kitagawa Y, Tanoue A
    Cardiovascular research 63 662-672 Sep. 2004
  • Identification of ectodomain regions contributing to gating, deactivation, and resensitization of purinergic P2X receptors.
    Zemkova H, He ML, Koshimizu TA, Stojilkovic SS
    The Journal of neuroscience : the official journal of the Society for Neuroscience 24 6968-6978 Aug. 2004
  • Vasopressin stimulates insulin release from islet cells through V1b receptors: a combined pharmacological/knockout approach.
    Oshikawa S, Tanoue A, Koshimizu TA, Kitagawa Y, Tsujimoto G
    Molecular pharmacology 65 623-629 Mar. 2004
  • The vasopressin V1b receptor critically regulates hypothalamic-pituitary-adrenal axis activity under both stress and resting conditions.
    Tanoue A, Ito S, Honda K, Oshikawa S, Kitagawa Y, Koshimizu TA, Mori T, Tsujimoto G
    The Journal of clinical investigation 113 302-309 Jan. 2004
  • Intracellular calcium measurements as a method in studies on activity of purinergic P2X receptor channels.
    He ML, Zemkova H, Koshimizu TA, Tomić M, Stojilkovic SS
    American journal of physiology. Cell physiology 285 C467-79 Aug. 2003
  • Recent advances in alpha1-adrenoceptor pharmacology.
    Koshimizu TA, Tanoue A, Hirasawa A, Yamauchi J, Tsujimoto G
    Pharmacology & therapeutics 98 235-244 May 2003
  • Insights into alpha1 adrenoceptor function in health and disease from transgenic animal studies.
    Tanoue A, Koshimizu TA, Shibata K, Nasa Y, Takeo S, Tsujimoto G
    Trends in endocrinology and metabolism: TEM 14 107-113 Apr. 2003
  • Heteromultimerization modulates P2X receptor functions through participating extracellular and C-terminal subdomains.
    Koshimizu TA, Ueno S, Tanoue A, Yanagihara N, Stojilkovic SS, Tsujimoto G
    The Journal of biological chemistry 277(49) 46891-46899 Dec. 2002
  • Purinergic P2X(2) receptor desensitization depends on coupling between ectodomain and C-terminal domain.
    He ML, Koshimizu TA, Tomić M, Stojilkovic SS
    Molecular pharmacology 62 1187-1197 Nov. 2002
  • Transgenic studies of alpha(1)-adrenergic receptor subtype function.
    Tanoue A, Koshimizu TA, Tsujimoto G
    Life sciences 71(19) 2207-2215 Sep. 2002
  • Two novel transcripts for human endothelin B receptor produced by RNA editing/alternative splicing from a single gene.
    Tanoue A, Koshimizu TA, Tsuchiya M, Ishii K, Osawa M, Saeki M, Tsujimoto G
    The Journal of biological chemistry 277(36) 33205-33212 Sep. 2002
  • Role of the alpha1D-adrenergic receptor in the development of salt-induced hypertension.
    Tanoue A, Koba M, Miyawaki S, Koshimizu TA, Hosoda C, Oshikawa S, Tsujimoto G
    Hypertension 40 101-106 Jul. 2002
  • Restored atrial excitability after late recanalization in a patient with atrial standstill and acute myocardial infarction.
    Koshimizu TA, Komori S, Ishihara T, Kohno I, Umetani K, Sawanobori T, Ijiri H, Tamura K
    Pacing and clinical electrophysiology : PACE 25 217-219 Feb. 2002

Papers(other)

  • Carvedilol selectively inhibits oscillatory intracellular calcium changes evoked by human alpha1D- and alpha1B-adrenergic receptors
    Cardiovasc Res 63 662 2004
  • Heteromultimerization modulates P2X receptor functions through participating extracellular and C-terminal subdomains.
    J Biol Chem 277 277(49) 46891-46899 2002
Display all
Papers(other)close
  • Carvedilol selectively inhibits oscillatory intracellular calcium changes evoked by human alpha1D- and alpha1B-adrenergic receptors
    Cardiovasc Res 63 662 2004
  • Heteromultimerization modulates P2X receptor functions through participating extracellular and C-terminal subdomains.
    J Biol Chem 277 277(49) 46891-46899 2002

Prize

  • 2004 2004 Young investigator award, Japanese cardiovascular pharmacology,
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Prizeclose
  • 2004 2004 Young investigator award, Japanese cardiovascular pharmacology,

Outside Fund Adoption

  • New genome medicine and drug discovery based on the comprehensive transcriptome analysis
    Ministry of Education, Culture, Sports, Science and Technology:Grants-in-Aid for Scientific Research(基盤研究(S))
    Project Year :2007 - 2011 Investigator(s) : Gozoh TSUJIMOTO
  • Identification of ligand and function of novel group of free fatty acid receptors by using genome information.
    Ministry of Education, Culture, Sports, Science and Technology:Grants-in-Aid for Scientific Research(基盤研究(A))
    Project Year :2005 - 2006 Investigator(s) : Gozoh TSUJIMOTO
  • Strategic evaluation of Receptor interaction using resonance energy transfer
    Ministry of Education, Culture, Sports, Science and Technology:Grants-in-Aid for Scientific Research(基盤研究(C))
    Project Year :2005 - 2006 Investigator(s) : Takaaki KOSHIMIZU
  • receptor biology using knockout mouse
    :Special Coordination Funds for Promoting Science and Technology
    Project Year :2004 - 2005
  • Drug development research for pain management
Display all
Outside Fund Adoptionclose
  • New genome medicine and drug discovery based on the comprehensive transcriptome analysis
    Ministry of Education, Culture, Sports, Science and Technology:Grants-in-Aid for Scientific Research(基盤研究(S))
    Project Year :2007 - 2011 Investigator(s) : Gozoh TSUJIMOTO
  • Identification of ligand and function of novel group of free fatty acid receptors by using genome information.
    Ministry of Education, Culture, Sports, Science and Technology:Grants-in-Aid for Scientific Research(基盤研究(A))
    Project Year :2005 - 2006 Investigator(s) : Gozoh TSUJIMOTO
  • Strategic evaluation of Receptor interaction using resonance energy transfer
    Ministry of Education, Culture, Sports, Science and Technology:Grants-in-Aid for Scientific Research(基盤研究(C))
    Project Year :2005 - 2006 Investigator(s) : Takaaki KOSHIMIZU
  • receptor biology using knockout mouse
    :Special Coordination Funds for Promoting Science and Technology
    Project Year :2004 - 2005
  • Drug development research for pain management

Works

  • Physiological analysis using knockout mouse
    2002-2005
  • Receptor molecular biology
    2000-2004
Display all
Worksclose
  • Physiological analysis using knockout mouse
    2002-2005
  • Receptor molecular biology
    2000-2004


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