Researchers Database

fujii hiroyuki

    Radiology Assistant Professor
Last Updated :2021/11/23

Researcher Information

J-Global ID

Research Areas

  • Life sciences / Radiology

Published Papers

  • Yoko Shigemoto, Daichi Sone, Norihide Maikusa, Yukio Kimura, Fumio Suzuki, Hiroyuki Fujii, Noriko Sato, Hiroshi Matsuda
    eNeurologicalSci 23 100343 - 100343 2021/06 
    Objective: The aim of this study was to evaluate tau-related structural network metrics derived from gray matter magnetic resonance imaging (MRI) scans in cognitively normal (CN) older adults. Methods: We recruited 47 amyloid-negative CN older adults (mean age ± standard deviation, 65.0 ± 7.9 years; 26 women). All participants underwent 3D T1-weighted MRI and 11C-Pittsburgh compound-B and 18F-THK5351 positron emission tomography scans. Four local network metrics (betweenness centrality, clustering coefficient, characteristic path length, and degree) were computed and rendered on individual brain images. We then evaluated the correlations between 18F-THK5351 positron emission tomography images and local network metric images at the voxel level. Results: Significant positive correlations of the four local network metrics with 18F-THK5351 were detected in the bilateral caudate. Conclusion: Our findings suggest that tau and neuroinflammation in CN older adults may influence the gray matter structural network in the caudate.
  • Yoko Shigemoto, Daichi Sone, Kyoji Okita, Norihide Maikusa, Tensho Yamao, Yukio Kimura, Fumio Suzuki, Hiroyuki Fujii, Koichi Kato, Noriko Sato, Hiroshi Matsuda
    eNeurologicalSci 22 100309 - 100309 2021/03 
    Objective: This study aimed to examine the alterations in gray matter networks related to tau retention in Alzheimer's disease (AD) patients and cognitively normal (CN) older individuals. Methods: Eighteen amyloid-positive AD patients and 30 age- and sex-matched amyloid-negative CN controls were enrolled. All underwent 3D T1-weighted MRI, amyloid positron-emission tomography imaging (PET) with 11C-Pittsburgh Compound B (PiB), and tau PET with 18F-THK5351. The structural networks extracted from the T1-weighted MRI data based on cortical similarities within single subjects were analyzed. Based on graph theoretical approach, global and local network properties across the whole brain were computed. Group comparisons of global and local network properties were evaluated between the groups. Then, we correlated the global and local network measures with total cerebral 18F-THK5351 retention. Results: AD patients moved toward more randomized global network compared to controls and regional differences were observed in the default mode network (DMN) area. No significant correlations existed between global network properties and tau retention. On a local level, AD and controls showed opposite relationships between network properties and tau retention mainly in the DMN areas; CN controls showed positive correlations, whereas AD showed negative correlations. Conclusion: We found opposite relationships between local network properties and tau retention between amyloid-positive AD patients and amyloid-negative controls. Our findings suggest that the presence of amyloid and induced exacerbated tau retention alter the relationship of local network properties and tau retention.
  • Atsuhiko Sugiyama, Noriko Sato, Yukio Kimura, Hiroyuki Fujii, Yoko Shigemoto, Fumio Suzuki, Zen-Ichi Tanei, Yuko Saito, Masayuki Sasaki, Yuji Takahashi, Hiroshi Matsuda, Satoshi Kuwabara
    Journal of the neurological sciences 416 117040 - 117040 2020/09 
    Dentatorubral-pallidoluysian atrophy (DRPLA) is an autosomal dominant neurodegenerative disorder caused by a CAG nucleotide repeat expansion in atrophin 1. A previous report described cerebellar white matter lesions on magnetic resonance imaging (MRI) in elderly-onset DRPLA patients, but this finding has not been fully investigated in a total population of DRPLA patients, including juvenile or early-adult onset patients. Herein, we attempted to determine the frequency, distribution pattern, and features of the cerebellar white matter lesions in 30 consecutive DRPLA patients. We also assessed the relationships between the cerebellar white matter lesions and clinical parameters and other MRI findings. The cerebellar white matter lesions were found in 43% of the 30 DRPLA patients, and in 70% of the late adult-onset DRPLA patients. In approx. Two-thirds of the patients with cerebellar white matter lesions, the lesions were localized in the paravermal area (paravermal lesions). Multiple logistic regression analyses revealed that the Fazekas grade of 'cerebral' white matter lesions was independently associated with 'cerebellar' white matter lesions. In conclusion, cerebellar white matter lesions are one of the distinctive MRI features in DRPLA patients, especially in patients with older age at onset. Cerebellar white matter lesions, as well as cerebral white matter lesions, might originate from the disease process of DRPLA itself, and they often have a characteristic distribution of paravermal lesions.
  • Hiroyuki Fujii, Noriko Sato, Yukio Kimura, Atsuhiko Sugiyama, Yoko Shigemoto, Fumio Suzuki, Hiroshi Matsuda, Masayuki Sasaki, Hideharu Sugimoto
    Japanese journal of radiology 38 (8) 731 - 739 2020/08 
    PURPOSE: The purpose of this study was to evaluate the delineation of nerve fiber bundles in the brainstem and optic radiation in infants associated with aging on T1WI, T2WI, and phase difference-enhanced (PADRE) images. MATERIALS AND METHODS: We retrospectively reviewed 21 consecutive subjects < 2 years old who underwent brain MRI without abnormal imaging findings. Two neuroradiologists evaluated the eight nerve fiber bundles in the brainstem and optic radiation using a 3-point scale focused on the contrast to surrounding brain parenchyma. We also evaluated the signal ratio of the optic radiation to surrounding white matter on PADRE for each month age. RESULTS: T2WI was able to delineate nerve fiber bundles better than T1WI at 1 month old, and the images gradually became unclear with aging. On PADRE, almost all nerve fiber bundles were unclear or invisible at 1 month old but gradually became clearer with aging. There was a significant negative correlation between age and the signal ratio of the optic radiation to surrounding white matter. CONCLUSIONS: The PADRE imaging was able to delineate the nerve fiber bundles in infants, and the delineation gradually became clearer with aging. The combination of PADRE, T1WI, and T2WI would be useful for evaluation of nerve fiber bundles in infants.
  • Tomohiro Kikuchi, Hiroyuki Fujii, Akifumi Fujita, Hideharu Sugimoto
    Japanese journal of radiology 38 (8) 753 - 760 2020/08 
    PURPOSE: To investigate the ability of three-dimensional double-echo steady-state with water excitation sequence (3D-DESS-WE) in detecting the greater occipital nerve (GON) and the lesser occipital nerve (LON). MATERIALS AND METHODS: We retrospectively reviewed 66 consecutive patients who underwent magnetic resonance imaging, including 3D-DESS-WE. Two readers evaluated the detectability [0 (poor) to 3 (excellent)] and thickness of the GON and LON. We calculated the average evaluation scores and interobserver variability for the detectability of the GON and LON. We also calculated the average nerve thickness for each of the two readers and the interobserver reproducibility for the thickness of the GON and LON. The interobserver variability was calculated using a weighted kappa analysis and the intraclass correlation coefficient (ICC) was used to evaluate the interobserver reproducibility of the nerve thickness. RESULTS: The respective average score, interobserver variability, thickness and interobserver reproducibility were 3.00, excellent (κ = 1.00), 1.07 ± 0.12 mm, and almost perfect (ICC = 0.82) for the GON and 1.81, good (κ = 0.73), 0.84 ± 0.11 mm, and substantial (ICC = 0.78) for the LON. The GON was significantly thicker than the LON (p < 0.001). CONCLUSION: The 3D-DESS-WE demonstrated excellent visualization of the GON and relatively good visualization of the LON.
  • Hiroyuki Fujii, Wakiro Sato, Yukio Kimura, Hiroshi Matsuda, Miho Ota, Norihide Maikusa, Fumio Suzuki, Keiko Amano, Isu Shin, Takashi Yamamura, Harushi Mori, Noriko Sato
    Journal of neuroimaging : official journal of the American Society of Neuroimaging 2020/07 
    BACKGROUND AND PURPOSE: Recent studies suggest that the autoantibodies against adrenergic/muscarinic receptors might be one of the causes and potential markers of myalgic encephalomyelitis/chronic fatigue syndrome (ME/CFS). The purpose of this study was to investigate the structural network changes related to autoantibody titers against adrenergic/muscarinic receptors in ME/CFS by performing a single-subject gray matter similarity-based structural network analysis. METHODS: We prospectively examined 89 consecutive right-handed ME/CFS patients who underwent both brain MRI including 3D T1-wighted images and a blood analysis of autoantibodies titers against β1 adrenergic receptor (β1 AdR-Ab), β2 AdR-Ab, M3 acetylcholine receptor (M3 AchR-Ab), and M4 AchR-Ab. Single-subject gray matter similarity-based structural networks were extracted from segmented gray matter images for each patient. We calculated local network properties (betweenness centrality, clustering coefficient, and characteristic path length) and global network properties (normalized path length λ, normalized clustering coefficient γ, and small-world network value δ). We investigated the correlations between the autoantibody titers and regional gray matter/white matter volumes, the local network properties, and the global network properties. RESULTS: Betweenness centrality showed a significant positive correlation with β1-AdR-Ab in the right dorsolateral prefrontal cortex. The characteristic path length showed a significant negative correlation with β2-AdR-Ab in the right precentral gyrus. There were no significant correlations between the antibody titers and the regional gray matter/white matter volumes, and the global network properties. CONCLUSIONS: Our findings suggest that β1 AdR-Ab and β2 AdR-Ab are potential markers of ME/CFS.
  • Yukio Kimura, Noriko Sato, Akihiko Ishiyama, Yoko Shigemoto, Fumio Suzuki, Hiroyuki Fujii, Norihide Maikusa, Hiroshi Matsuda, Kenya Nishioka, Nobutaka Hattori, Masayuki Sasaki
    Journal of neuroradiology = Journal de neuroradiologie 2020/04 
    BACKGROUND AND PURPOSE: Beta-propeller protein-associated neurodegeneration (BPAN) is one subtype of neurodegeneration with brain iron accumulation. It is difficult to diagnose BPAN due to the non-specificity of their clinical findings and neuroimaging in early childhood. We experienced four pediatric patients with serial brain MRI and evaluated the alteration of the findings through their course. METHODS: We retrospectively reviewed the clinical findings and 21 MRI findings of the four patients with genetically confirmed pediatric BPAN. We also performed a quantitative MR assessment using the quantitative susceptibility mapping (QSM) values of the globus pallidus (GP), substantia nigra (SN), and deep cerebellar nuclei (DCN) compared to 10 age-matched disease controls. RESULTS: Only one patient was suspected of BPAN based on imaging findings before the genetic diagnosis was made. The other three patients could not be suspected until their Whole-exome sequencings (WES) done. In all four cases, no abnormal signals were noted in the GP and SN at the initial brain MRI, but hypointensities were observed after the ages of 4-7 years on T2-weighted images and after the ages of 2-7 years on susceptibility-weighted images. In three patients, T2 hyperintensity in the bilateral DCN was persistently observed throughout the observational period. Three patients showed transient T2 hyperintensity and swelling in the GP, SN and/or DCN during the episodes of pyrexia and seizures. The other findings included cerebral and cerebellar atrophy, thinning of the corpus callosum, and delayed myelination. The QSM values of the GP and SN were significantly higher in the patients compared to the controls (P=0.005, respectively), but that of the DCN did not differ significantly (P=0.16). CONCLUSION: Brain MRI is a useful method to establish the early diagnosis of BPAN.
  • Hiroyuki Fujii, Noriko Sato, Jun-Ichi Takanashi, Yukio Kimura, Emiko Morimoto, Yoko Shigemoto, Fumio Suzuki, Masayuki Sasaki, Hideharu Sugimoto
    Brain & development 42 (3) 302 - 306 2020/03 
    Autosomal recessive PRUNE1 mutations on chromosome 1q21.3 are reported to cause a neurodevelopmental disorder with microcephaly, hypotonia, and variable brain malformations. Here, we report a Japanese case with a reported PRUNE1 mutation whose brain magnetic resonance imaging (MRI) showed specific imaging findings that have not been reported before. The patient was a 12-month-old girl, the first child of healthy and nonconsanguineous Japanese parents. She showed global developmental delay, intellectual disability, hypotonia, spastic quadriparesis, and hyperreflexia. Brain MRI showed cerebral and cerebellar atrophy, thin corpus callosum, white matter changes, and abnormal signal intensity of the brainstem, all of which were reported in the literature. In addition, we emphasize the three following imaging findings: a transient cerebral subcortical white matter lesion, atrophy of the midbrain and pontine tegmentum with a preserved pontine base, and abnormal signal intensity of the bilateral swelling putamina and medial portions of the thalami, which emerged after 4 years of age. The whole-exome sequencing (WES) analysis performed at the age of 4 years identified biallelic PRUNE1 variants, namely compound heterozygous mutations (c.[316G > A];[540 T > A],p.[Asp106Asn];[Cys180*]). Although the diagnosis of PRUNE1-related disorder requires WES, we think that these new characteristic MRI findings may help in the diagnosis of PRUNE1-related disorder.
  • Atsushi Ugajin, Hiroyuki Fujii, Akifumi Fujita, Hiroyasu Nakamura, Akira Fujisaki, Hideharu Sugimoto
    Radiology case reports 15 (3) 285 - 291 2020/03 
    We describe the case of an adult female with a huge pelvic arteriovenous malformation (AVM) measuring approx. 8 × 10 × 13 cm, treated via the transvenous approach alone. Management of huge pelvic AVMs is challenging; there is no consensus on a standardized treatment strategy. In our patient, multiple arterioles shunted to prominently dilated outflow veins. Selective occlusion of prominent outflow veins as close to the nidus as possible achieved significant flow reduction through the nidus. Our treatment may be a safe and acceptable option to control hematuria for huge pelvic AVMs associated with prominent outflow veins, especially when both transarterial embolization and direct puncture are difficult.
  • Atsuhiko Sugiyama, Noriko Sato, Yukio Kimura, Hiroyuki Fujii, Norihide Maikusa, Yoko Shigemoto, Fumio Suzuki, Emiko Morimoto, Kyosuke Koide, Yuji Takahashi, Hiroshi Matsuda, Satoshi Kuwabara
    Journal of the neurological sciences 407 116525 - 116525 2019/12 
    We used quantitative susceptibility mapping (QSM) to assess the brain iron deposition in 28 patients with the cerebellar subtype of multiple system atrophy (MSA-C), nine patients with spinocerebellar ataxia type 6 (SCA6), and 23 healthy controls. Two reviewers independently measured the mean QSM values in brain structures including the putamen, globus pallidus, caudate nucleus, red nucleus, substantia nigra, and cerebellar dentate nucleus. A receiver operating characteristics (ROC) analysis was performed to assess the diagnostic usefulness of the QSM measurements. The QSM values in the substantia nigra were significantly higher in the MSA-C group compared to the HC group (p = .007). The QSM values in the cerebellar dentate nucleus were significantly higher in MSA-C than those in the SCA6 and HC groups (p < .001), and significantly lower in the SCA6 patients compared to the HCs (p = .027). The QSM values in the cerebellar dentate nucleus were correlated with disease duration in MSA-C, but inversely correlated with disease duration in SCA6. In the ROC analysis, the QSM values in the cerebellar dentate nucleus showed excellent accuracy for differentiating MSA-C from SCA6 (area under curve [AUC], 0.925), and good accuracy for differentiating MSA-C from healthy controls (AUC 0.834). QSM can identify increased susceptibility of the substantia nigra and cerebellar dentate nucleus in MSA-C patients. These results suggest that an increase in iron accumulation in the cerebellar dentate nucleus may be secondary to the neurodegeneration associated with MSA-C.
  • Fumio Suzuki, Noriko Sato, Atsuhiko Sugiyama, Keiya Iijima, Yoko Shigemoto, Emiko Morimoto, Yukio Kimura, Hiroyuki Fujii, Yuji Takahashi, Yasuhiro Nakata, Hiroshi Matsuda, Osamu Abe
    Journal of neuroradiology = Journal de neuroradiologie 2019/12 
    BACKGROUND AND PURPOSE: Chorea-acanthocytosis, a rare neurodegenerative disease, affects both the striatum and the medial temporal lobe which may cause involuntary movements and epilepsy, respectively. We examined the imaging changes of the hippocampus/amygdala and the striatum as well as clinical symptoms. MATERIALS AND METHODS: We retrospectively reviewed 29 MRI and 13 SPECT studies and the clinical findings of seven genetically confirmed chorea-acanthocytosis patients. We evaluated the time-dependent imaging changes of the hippocampus/amygdala and striatum and examined the relationships among these images and symptoms. RESULTS: The initial symptom was epilepsy in four patients and involuntary movements in three patients. These symptoms were eventually noted in five and all seven patients, respectively. On MRI, most patients showed striatum atrophy before a hippocampus/amygdala abnormality emerged, but one patient showed a hippocampus/amygdala abnormality before striatum atrophy. Abnormal MRI findings of hippocampus/amygdala were noted in five patients and atrophy of striatum in all seven patients. SPECT demonstrated hypoperfusion of hippocampus/amygdala in three patients and that of striatum in all five available patients. Four patients demonstrated hypoperfusion of striatum earlier than that of hippocampus/amygdala and one patient showed hypoperfusion of both simultaneously. Many imaging abnormal lesions were accompanied by their corresponding symptoms, but not always so. CONCLUSION: Striatum abnormalities were the initial imaging findings in many chorea-acanthocytosis patients, but epilepsy or hippocampus/amygdala imaging abnormalities may be the only findings at the early stage. It is important to understand the detailed clinical and imaging time courses for the diagnosis of chorea-acanthocytosis.
  • Yoko Shigemoto, Daichi Sone, Miho Ota, Norihide Maikusa, Masayo Ogawa, Kyoji Okita, Harumasa Takano, Koichi Kato, Yukio Kimura, Emiko Morimoto, Fumio Suzuki, Hiroyuki Fujii, Noriko Sato, Hiroshi Matsuda
    EJNMMI research 9 (1) 81 - 81 2019/08 
    BACKGROUNDS: Although neurofibrillary tangles (NFTs) mainly accumulate in the medial temporal lobe with human aging, only a few imaging studies have investigated correlations between NFT accumulation and gray matter (GM) volume in cognitively normal older adults. Here, we investigated the correlations between 18F-THK5351 accumulation and GM volume at the voxel level. MATERIAL AND METHODS: We recruited 47 amyloid-negative, cognitively normal, older adults (65.0 ± 7.9 years, 26 women), who underwent structural magnetic resonance imaging, 11C-Pittsburgh compound-B and 18F-THK5351 PET scans, and neuropsychological assessment. The magnetic resonance and 18F-THK5351 PET images were spatially normalized using Statistical Parametric Mapping 12. Voxel-wise correlations between 18F-THK5351 accumulation and GM volume were evaluated using the Biological Parametric Mapping toolbox. RESULTS: A significant negative correlation (p < 0.001) between 18F-THK5351 accumulation and GM volume was detected in the bilateral medial temporal lobes. CONCLUSIONS: Voxel-wise correlation analysis revealed a significant negative correlation between 18F-THK5351 accumulation and GM volume in the medial temporal lobe in individuals without amyloid-β deposits. These results may contribute to a better understanding of the pathophysiology of primary age-related tauopathy in human aging.
  • H Fujii, A Fujita, H Kanazawa, E Sung, O Sakai, H Sugimoto
    AJNR. American journal of neuroradiology 40 (6) 1037 - 1042 2019/06 
    BACKGROUND AND PURPOSE: Reliable preoperative facial nerve mapping may help avoid or minimize facial nerve injury during parotid tumor resection. The purpose of this study was to investigate the diagnostic performance of the 3D double-echo steady-state with water excitation sequence in localizing parotid gland tumors through direct visualization of the intraparotid facial nerve in comparison with indirect methods of estimating the facial nerve location. MATERIALS AND METHODS: We retrospectively reviewed 91 parotid gland tumors in 90 patients who underwent surgical resection and preoperative MR imaging, including the 3D double-echo steady-state with water excitation sequence. The tumor locations were categorized as deep or superficial on the basis of direct and 3 indirect methods: the facial nerve line, retromandibular vein, and Utrecht line. Surgical localization was considered the criterion standard. The diagnostic performance for localizing deep lobe lesions using direct and indirect methods was calculated and compared using the McNemar test. RESULTS: Surgical localization confirmed 75 superficial lesions and 16 deep lesions. The interobserver variability of the 3D double-echo steady-state with water excitation sequence was excellent (κ = 0.870). The diagnostic accuracy, sensitivity, specificity, positive predictive value, and negative predictive value for localizing deep lobe lesions using the 3D double-echo steady-state with water excitation method were 97.8%, 87.5%, 100%, 100%, and 97.4%, respectively. These findings were significantly higher than the facial nerve line in sensitivity, the retromandibular vein in sensitivity, and the Utrecht line in accuracy and specificity (P < .05). Overall, the direct method was the most accurate, sensitive, and specific in localizing parotid gland tumors. CONCLUSIONS: We can achieve higher diagnostic performance in localizing parotid gland tumors by directly visualizing the intraparotid facial nerve using the 3D double-echo steady-state with water excitation sequence compared with indirect methods.
  • 木島 茂喜, 歌野 健一, 佐々木 崇洋, 金澤 英紀, 藤井 裕之, 杉本 英治
    臨床消化器内科 (株)日本メディカルセンター 34 (3) 253 - 257 0911-601X 2019/02 
    <文献概要>CT技術の進歩により検出器が多列化され,短時間で高精細な画像が得られるようになった.これによりCT colonographyの画質も担保されるようになった.画像の解析に当たってはワークステーションが必須である.今日のワークステーションは,virtual dissection(仮想展開画像),electronic cleansing(電子洗浄)などを行うさまざまな3D解析ソフトウエアが搭載されている.CAD(computer aided detection,コンピュータ診断支援)も日常診療で使用可能となっている.新たなソフトウエアは読影時間の短縮や死角となる病変の描出に寄与する可能性がある.しかし,歪みや評価すべき画像の増加,特異度の低下など,悪影響も考慮する必要がある.精度を上げるための開発は続けられているが,まずは標準的な方法での読影が求められる.
  • Atsushi Ugajin, Hiroyuki Fujii, Hiroyasu Nakamura, Akifumi Fujita, Takahiro Sasaki, Naoko Mato, Hideharu Sugimoto
    Case reports in radiology 2019 1725238 - 1725238 2019 
    Rasmussen's aneurysm is a peripheral pulmonary artery pseudoaneurysm (PAP) within a tuberculosis cavity. Because it can be perfused from the bronchial and pulmonary arterial circulations, combined embolization via the bronchial and pulmonary arteries is sometimes required. Herein, we present case of a 51-year-old man with Rasmussen's aneurysm that was successfully treated by proximal coil blocking with n-butyl-2-cyanoacrylate (NBCA) injection via the pulmonary artery alone. With proximal coil blocking, a sufficient amount of NBCA could be injected without unintended reflux of the NBCA cast to the proximal pulmonary artery. To our knowledge, there has been no report that attempted NBCA injection under proximal coil blocking for Rasmussen's aneurysm. Our treatment approach may be safe and effective for infectious lung disease-related PAP, which has to be treated from the pulmonary artery side.
  • Naoki Kunitomo, Hiroyuki Fujii, Akifumi Fujita, Yumiko Hamano, Minako Takanosawa, Hideharu Sugimoto
    Case reports in radiology 2019 3067346 - 3067346 2019 
    Thyroglossal duct (TGD) carcinoma is a rare malignant tumor arising from remnants of thyroid tissue or the wall of the duct and generally occurs along the anatomic course of the TGD. TGD carcinoma originating in the hyoid bone is extremely rare but can occur since the TGD penetrates the hyoid bone on rare occasions. This report describes the case of a 30-year-old man with TGD carcinoma originating in the hyoid bone. Computed tomography demonstrated a mass in the hyoid bone that expanded the cortical bone of the hyoid. The mass had a central solid component with calcification and a marginal cystic component. When we encounter a calcified mass in the hyoid bone, we should consider TGD carcinoma among the differential diagnoses.
  • Nana Fujii, Hiroyuki Fujii, Akifumi Fujita, Younhee Kim, Hideharu Sugimoto
    Radiology case reports 13 (4) 834 - 838 2018/08 
    Spontaneous intracranial hypotension (SIH) is a well-known cause of orthostatic headache. Although subdural fluid collection is a usual complication of SIH, SIH as a risk factor for cerebral venous thrombosis (CVT) is not well-known. There are several mechanisms that could contribute to the development of CVT in SIH. Herein, we report a case of a 33-year-old woman with SIH complicated by CVT. She was treated with anticoagulation but did not receive a blood patch for the SIH, because there was resolution of orthostatic headache with bed rest and sufficient hydration. Follow-up magnetic resonance imaging showed resolution of the findings of SIH and CVT. Patients with SIH should be closely observed for any change in the headache pattern, which might suggest the development of CVT.
  • Tomohiro Kikuchi, Hiroyuki Fujii, Akifumi Fujita, Tomoko Sugiyama, Hideharu Sugimoto
    Case reports in radiology 2018 9142362 - 9142362 2018 
    Synovitis, acne, pustulosis, hyperostosis, and osteitis (SAPHO) syndrome is a disorder characterized by pustular skin lesions and osteoarticular lesions. Mandibular involvement of SAPHO syndrome is clinically rare, and it is difficult to reach a diagnosis of SAPHO syndrome from only mandibular manifestations. This report describes the case of a 26-year-old woman who presented with mandibular osteitis. Orthopantomogram and computed tomography showed sclerotic change of the right body of the mandible with periosteal reaction without odontogenic infection, which suggested the possibility of SAPHO syndrome. Detailed medical interview found that she had a history of palmoplantar pustulosis treated at a local dermatology clinic and additional bone scintigraphy showed diffuse increased uptake in the right mandible, as well as in the sternum and the sternocostoclavicular joints. She was eventually diagnosed as having SAPHO syndrome. We should consider SAPHO syndrome when we encounter a patient with mandibular osteitis of unknown etiology.
  • Hiroyuki Fujii, Akifumi Fujita, Hiroyasu Nakamura, Takahiro Sasaki, Hideharu Sugimoto
    Case reports in radiology 2016 2707195 - 2707195 2016 
    Massive hemoptysis is a life threatening respiratory emergency with high mortality and the bronchial artery (BA) is its most frequent source. Herein, we report a case of a 76-year-old man with recurrent hemoptysis due to an aberrant right BA arising from the right internal mammary artery (IMA), an extremely rare origin, that was clearly depicted on pretreatment computed tomography angiography (CTA). The patient was treated successfully by transcatheter bronchial artery embolization (BAE) of the aberrant BA and the hemoptysis has since been controlled for 9 months. Knowledge of the detailed BA anatomy is essential for performing BAE, especially in cases of aberrant BA. CTA is a promising tool for pretreatment planning of emergency BAE in patients with hemoptysis.
  • H Fujii, A Fujita, A Yang, H Kanazawa, K Buch, O Sakai, H Sugimoto
    AJNR. American journal of neuroradiology 36 (7) 1333 - 7 2015/07 
    BACKGROUND AND PURPOSE: Although visualization of the extracranial branches of the cranial nerves has improved with advances in MR imaging, only limited studies have assessed the detection of extracranial branches of the mandibular nerve (V3). We investigated the detectability of the branches of V3 on a 3D double-echo steady-state with water excitation sequence. MATERIALS AND METHODS: We retrospectively evaluated the detectability of the 6 branches of the V3, the masseteric, buccal, auriculotemporal, lingual, inferior alveolar, and mylohyoid nerves, by using a 5-point scale (4, excellent; 3, good; 2, fair; 1, poor; and 0, none) in 86 consecutive patients who underwent MR imaging with the 3D double-echo steady-state with water excitation sequence. Weighted κ analysis was used to calculate interobserver variability among the 3 readers. RESULTS: The detection of the lingual and inferior alveolar nerves was the most successful, with excellent average scores of 3.80 and 3.99, respectively. The detection of the masseteric, the buccal, and the auriculotemporal nerves was good, with average scores of 3.31, 2.67, and 3.11, respectively. The mylohyoid nerve was difficult to detect with poor average scores of 0.62. All nerves had excellent interobserver variability across the 3 readers (average weighted κ value, 0.95-1.00). CONCLUSIONS: The 3D double-echo steady-state with water excitation sequence demonstrated excellent visualization of the extracranial branches of V3 in most patients. The 3D double-echo steady-state with water excitation sequence has the potential for diagnosing V3 pathologies and preoperatively identifying peripheral cranial nerves to prevent surgical complications.
  • Takeshi Shinozaki, Kenichi Utano, Hiroyuki Fujii, Yuka Utano, Takahiro Sasaki, Shigeyoshi Kijima, Hidenori Kanazawa, Yukio Kimura, Akifumi Fujita, Hideharu Sugimoto
    Japanese journal of radiology 32 (8) 476 - 81 2014/08 
    OBJECTIVE: The objective of this study was to compare the diagnostic accuracy of dual-time-point 18F-fluorodeoxyglucose ((18)F-FDG) positron emission tomography (PET) to single-time-point (18)F-FDG PET for staging of preoperative lung cancer. METHODS: Between November 2008 and December 2009, 107 patients who were diagnosed as having lung cancer or strongly suspected of having lung cancer were enrolled. They underwent dual-time-point (18)F-FDG PET following conventional imaging. Dual-time-point (18)F-FDG PET imaging (whole body) was performed at 1-h (early) post-FDG injection and repeated (2 h delayed) after injection. The diagnostic accuracy of pre-PET staging and post-PET staging was retrospectively evaluated, and the diagnostic accuracy of dual-time-point (18)F-FDG PET was compared to that of single-time-point (18)F-FDG PET. RESULTS: In 100 patients, the early (18)F-FDG PET scan resulted in upstaging of the tumor in ten (10 %) and down-staging of the tumor in five (5 %) compared to the conventional scan. The delayed phase of (18)F-FDG PET provided no additional information on staging for lung cancer patients. The remaining seven patients were diagnosed as not having lung cancer. CONCLUSION: This study confirmed that dual-time-point (18)F-FDG PET is useful for differential diagnosis between benign and malignant lesions, but has no major impact on staging and therapeutic management of patients with pathologically proven lung cancer.
  • Shigeki Matsubara, Hiroaki Nonaka, Mami Kobayashi, Akira Kawai, Hiroyuki Fujii
    International journal of gynaecology and obstetrics: the official organ of the International Federation of Gynaecology and Obstetrics 125 (1) 84 - 5 2014/04
  • Shigeki Matsubara, Hiroaki Nonaka, Mami Kobayashi, Tomoyuki Kuwata, Hiroyuki Fujii
    Acta obstetricia et gynecologica Scandinavica 93 (1) 122 - 3 2014/01
  • 骨シンチグラフィの尿路所見 Do you have checked for urinary tract on bone scintigraphy?
    篠崎 健史, 藤井 裕之, 中田 有香, 歌野 健一, 金澤 英紀, 木島 茂喜, 杉本 英治
    日本医学放射線学会学術集会抄録集 (公社)日本医学放射線学会 72回 S157 - S157 0048-0428 2013/02


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