matubara daisuke

FacultyDepartmentofPathology,DivisionofIntegrativePathology
Job titleAssociate ProfessorWeb site

Profile

Research Keywords

    MET, KRAS, CK7, BRG1, MUC1, EGFR, TTF-1, EMT, BRM, Lung adenocarcinoma, MET inhibitor, CADM1, miRNA

Research Areas

  • Basic medicine / Human pathology
  • Oncology / Tumor diagnostics

Career

  • Jun.2016
    -
    Today
    IMSUT, Visiting Associate Professor
  • Jun.2015
    -
    Today
    Jichi Medical University Department of pathology, Associate professor

Academic Societies

  • THE JAPANESE CANCER ASSOCIATION
  • THE JAPANESE SOCIETY OF PATHOLOGY
  • THE JAPAN LUNG CANCER SOCIETY
  • THE JAPANESE SOCIETY OF CLINICAL CYTOLOGY
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  • THE JAPANESE CANCER ASSOCIATION
  • THE JAPANESE SOCIETY OF PATHOLOGY
  • THE JAPAN LUNG CANCER SOCIETY
  • THE JAPANESE SOCIETY OF CLINICAL CYTOLOGY

Research Activities

Papers(paper)

  • Loss of TSLC1 expression in lung adenocarcinoma: relationships with histological subtypes, sex and prognostic significance.
    Goto A, Niki T, Chi-Pin L, Matsubara D, Murakami Y, Funata N, Fukayama M
    Cancer science 96 480-486 Aug. 2005
  • Differential expression of S100A2 and S100A4 in lung adenocarcinomas: clinicopathological significance, relationship to p53 and identification of their target genes.
    Matsubara D, Niki T, Ishikawa S, Goto A, Ohara E, Yokomizo T, Heizmann CW, Aburatani H, Moriyama S, Moriyama H, Nishimura Y, Funata N, Fukayama M
    Cancer science 96 844-857 Dec. 2005
  • Decrease in Epstein-Barr virus-positive AIDS-related lymphoma in the era of highly active antiretroviral therapy.
    Hishima T, Oyaizu N, Fujii T, Tachikawa N, Ajisawa A, Negishi M, Nakamura T, Iwamoto A, Hayashi Y, Matsubara D, Sasao Y, Kimura S, Kikuchi Y, Teruya K, Yasuoka A, Oka S, Saito K, Mori S, Funata N, Sata T, Katano H
    Microbes and infection / Institut Pasteur 8 1301-1307 Apr. 2006
  • Distinct expression of Kaposi's sarcoma-associated herpesvirus-encoded proteins in Kaposi's sarcoma and multicentric Castleman's disease.
    Abe Y, Matsubara D, Gatanaga H, Oka S, Kimura S, Sasao Y, Saitoh K, Fujii T, Sato Y, Sata T, Katano H
    Pathology international 56 617-624 Oct. 2006
  • Pulmonary lymphoma developed during long-term methotrexate therapy for psoriasis.
    Suzuki M, Hirano S, Ito H, Matsubara D, Kubota K, Takeda Y, Sugiyama H, Kobayashi N, Kudo K
    Respirology (Carlton, Vic.) 12 774-776 Sep. 2007
  • Constitutive activation of c-Met is correlated with c-Met overexpression and dependent on cell-matrix adhesion in lung adenocarcinoma cell lines.
    Nakamura Y, Matsubara D, Goto A, Ota S, Sachiko O, Ishikawa S, Aburatani H, Miyazawa K, Fukayama M, Niki T
    Cancer science 99 14-22 Jan. 2008
  • Subepithelial myofibroblast in lung adenocarcinoma: a histological indicator of excellent prognosis.
    Matsubara D, Morikawa T, Goto A, Nakajima J, Fukayama M, Niki T
    Modern pathology : an official journal of the United States and Canadian Academy of Pathology, Inc 22 776-785 Jun. 2009
  • Heterogeneous expression of nestin in myofibroblasts of various human tissues.
    Kishaba Y, Matsubara D, Niki T
    Pathology international 60 378-385 May 2010
  • Molecular predictors of sensitivity to the MET inhibitor PHA665752 in lung carcinoma cells.
    Matsubara D, Ishikawa S, Oguni S, Aburatani H, Fukayama M, Niki T
    Journal of thoracic oncology : official publication of the International Association for the Study of Lung Cancer 5 1317-1324 Sep. 2010
  • Co-activation of epidermal growth factor receptor and c-MET defines a distinct subset of lung adenocarcinomas.
    Matsubara D, Ishikawa S, Sachiko O, Aburatani H, Fukayama M, Niki T
    The American journal of pathology 177 2191-2204 Nov. 2010
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Papers(paper)close
  • Loss of TSLC1 expression in lung adenocarcinoma: relationships with histological subtypes, sex and prognostic significance.
    Goto A, Niki T, Chi-Pin L, Matsubara D, Murakami Y, Funata N, Fukayama M
    Cancer science 96 480-486 Aug. 2005
  • Differential expression of S100A2 and S100A4 in lung adenocarcinomas: clinicopathological significance, relationship to p53 and identification of their target genes.
    Matsubara D, Niki T, Ishikawa S, Goto A, Ohara E, Yokomizo T, Heizmann CW, Aburatani H, Moriyama S, Moriyama H, Nishimura Y, Funata N, Fukayama M
    Cancer science 96 844-857 Dec. 2005
  • Decrease in Epstein-Barr virus-positive AIDS-related lymphoma in the era of highly active antiretroviral therapy.
    Hishima T, Oyaizu N, Fujii T, Tachikawa N, Ajisawa A, Negishi M, Nakamura T, Iwamoto A, Hayashi Y, Matsubara D, Sasao Y, Kimura S, Kikuchi Y, Teruya K, Yasuoka A, Oka S, Saito K, Mori S, Funata N, Sata T, Katano H
    Microbes and infection / Institut Pasteur 8 1301-1307 Apr. 2006
  • Distinct expression of Kaposi's sarcoma-associated herpesvirus-encoded proteins in Kaposi's sarcoma and multicentric Castleman's disease.
    Abe Y, Matsubara D, Gatanaga H, Oka S, Kimura S, Sasao Y, Saitoh K, Fujii T, Sato Y, Sata T, Katano H
    Pathology international 56 617-624 Oct. 2006
  • Pulmonary lymphoma developed during long-term methotrexate therapy for psoriasis.
    Suzuki M, Hirano S, Ito H, Matsubara D, Kubota K, Takeda Y, Sugiyama H, Kobayashi N, Kudo K
    Respirology (Carlton, Vic.) 12 774-776 Sep. 2007
  • Constitutive activation of c-Met is correlated with c-Met overexpression and dependent on cell-matrix adhesion in lung adenocarcinoma cell lines.
    Nakamura Y, Matsubara D, Goto A, Ota S, Sachiko O, Ishikawa S, Aburatani H, Miyazawa K, Fukayama M, Niki T
    Cancer science 99 14-22 Jan. 2008
  • Subepithelial myofibroblast in lung adenocarcinoma: a histological indicator of excellent prognosis.
    Matsubara D, Morikawa T, Goto A, Nakajima J, Fukayama M, Niki T
    Modern pathology : an official journal of the United States and Canadian Academy of Pathology, Inc 22 776-785 Jun. 2009
  • Heterogeneous expression of nestin in myofibroblasts of various human tissues.
    Kishaba Y, Matsubara D, Niki T
    Pathology international 60 378-385 May 2010
  • Molecular predictors of sensitivity to the MET inhibitor PHA665752 in lung carcinoma cells.
    Matsubara D, Ishikawa S, Oguni S, Aburatani H, Fukayama M, Niki T
    Journal of thoracic oncology : official publication of the International Association for the Study of Lung Cancer 5 1317-1324 Sep. 2010
  • Co-activation of epidermal growth factor receptor and c-MET defines a distinct subset of lung adenocarcinomas.
    Matsubara D, Ishikawa S, Sachiko O, Aburatani H, Fukayama M, Niki T
    The American journal of pathology 177 2191-2204 Nov. 2010
  • Six-year-old girl with primary cutaneous aggressive epidermotropic CD8+ T-cell lymphoma.
    Kikuchi Y, Kashii Y, Gunji Y, Morimoto A, Masuzawa A, Takatsuka Y, Fujita E, Komine M, Ohtsuki M, Matsubara D, Kobayashi C, Sakurai A, Yanase K, Kato K, Koike K, Tsuchida M, Momoi MY
    Pediatrics international : official journal of the Japan Pediatric Society 53 393-396 Jun. 2011
  • Epidermal growth factor receptor mutation and chemosensitivity.
    Matsubara D, Niki T
    Journal of thoracic oncology : official publication of the International Association for the Study of Lung Cancer 7 771-2; author reply 772 Apr. 2012
  • Is there a link between diabetic glomerular injury and crescent formation? A case report and literature review.
    Otani N, Akimoto T, Yumura W, Matsubara D, Iwazu Y, Numata A, Miki T, Takemoto F, Fukushima N, Muto S, Kusano E
    Diagnostic pathology 7 46 Apr. 2012
  • A clinicopathological and immunohistochemical study of gastric cancer with squamous cell carcinoma components: a clinically aggressive tumor.
    Saito S, Hosoya Y, Morishima K, Ui T, Haruta H, Kurashina K, Meguro Y, Zuiki T, Sata N, Fujii H, Matsubara D, Niki T, Lefor AT, Yasuda Y
    Journal of digestive diseases 13 407-413 Aug. 2012
  • Identification of CCDC6-RET fusion in the human lung adenocarcinoma cell line, LC-2/ad.
    Matsubara D, Kanai Y, Ishikawa S, Ohara S, Yoshimoto T, Sakatani T, Oguni S, Tamura T, Kataoka H, Endo S, Murakami Y, Aburatani H, Fukayama M, Niki T
    Journal of thoracic oncology : official publication of the International Association for the Study of Lung Cancer 7 1872-1876 Dec. 2012
  • Lung cancer with loss of BRG1/BRM, shows epithelial mesenchymal transition phenotype and distinct histologic and genetic features.
    Matsubara D, Kishaba Y, Ishikawa S, Sakatani T, Oguni S, Tamura T, Hoshino H, Sugiyama Y, Endo S, Murakami Y, Aburatani H, Fukayama M, Niki T
    Cancer science 104 266-273 Feb. 2013
  • Expression of PRMT5 in lung adenocarcinoma and its significance in epithelial-mesenchymal transition.
    Ibrahim R, Matsubara D, Osman W, Morikawa T, Goto A, Morita S, Ishikawa S, Aburatani H, Takai D, Nakajima J, Fukayama M, Niki T, Murakami Y
    Human pathology 45 1397-1405 Jul. 2014
  • Stromal fibroblasts are predictors of disease-related mortality in esophageal squamous cell carcinoma.
    Saito S, Morishima K, Ui T, Matsubara D, Tamura T, Oguni S, Hosoya Y, Sata N, Lefor AT, Yasuda Y, Niki T
    Oncology reports 32 348-354 Jul. 2014
  • Immunohistochemical analysis of the expression of E-cadherin and ZEB1 in non-small cell lung cancer.
    Matsubara D, Kishaba Y, Yoshimoto T, Sakuma Y, Sakatani T, Tamura T, Endo S, Sugiyama Y, Murakami Y, Niki T
    Pathology international 64 560-568 Nov. 2014
  • Loss of YAP1 Defines Neuroendocrine Differentiation of Lung Tumors.
    Ito T, Matsubara D, Tanaka I, Makiya K, Tanei ZI, Kumagai Y, Shiu SJ, Nakaoka HJ, Ishikawa S, Isagawa T, Morikawa T, Shinozaki-Ushiku A, Goto Y, Nakano T, Tsuchiya T, Tsubochi H, Komura D, Aburatani H, Dobashi Y, Nakajima J, Endo S, Fukayama M, Sekido Y, Niki T, Murakami Y.
    Cancer Science Jul. 2016
  • p53 Is a Host Cell Regulator during Herpes Simplex Encephalitis.
    Maruzuru Y, Koyanagi N, Takemura N, Uematsu S, Matsubara D, Suzuki Y, Arii J, Kato A, Kawaguchi Y.
    J Virol Jul. 2016
  • A novel mouse model of intrahepatic cholangiocarcinoma induced by liver-specific Kras activation and Pten deletion.
    Ikenoue T, Terakado Y, Nakagawa H, Hikiba Y, Fujii T, Matsubara D, Noguchi R, Zhu C, Yamamoto K, Kudo Y, Asaoka Y, Yamaguchi K, Ijichi H, Tateishi K, Fukushima N, Maeda S, Koike K, Furukawa Y.
    Sci Rep 6(23899) 1-9 Apr. 2016
  • Addiction to the IGF2-ID1-IGF2 circuit for maintenance of the breast cancer stem-like cells.
    Tominaga K, Shimamura T, Kimura N, Murayama T, Matsubara D, Kanauchi H, Niida A, Shimizu S, Nishioka K, Tsuji EI, Yano M, Sugano S, Shimono Y, Ishii H, Saya H, Mori M, Akashi K, Tada KI, Ogawa T, Tojo A, Miyano S, Gotoh N.
    Oncogene Aug. 2016
  • Pancreatic neuroendocrine tumor with metastasis to the spleen: a case report.
    Sakuma Y, Yasuda Y, Sata N, Hosoya Y, Shimizu A, Fujii H, Matsubara D, Fukushima N, Miki A, Maeno M, Lefor AK.
    BMC Cancer 17(1) Jan. 2017
  • Identification of cell-type-specific mutations in nodal T-cell lymphomas
    Tran B. Nguyen, Mamiko Sakata-Yanagimoto, Yukitsugu Asabe, Daisuke Matsubara, Junko Kano, Kenichi Yoshida, Yuichi Shiraishi, Kenichi Chiba, Hiroko Tanaka, Satoru Miyano, Koji Izutsu, Naoya Nakamura, Kengo Takeuchi, Hiroaki Miyoshi, Koichi Ohshima, Takashi Minowa, Seishi Ogawa, Masayuki Noguchi and Shigeru Chiba.
    Blood Cancer Journal Jan. 2017
  • Frequent loss of the expression of multiple subunits of the SWI/SNF complex in large cell carcinoma and pleomorphic carcinoma of the lung.
    Yoshimoto T, Matsubara D, Nakano T, Tamura T, Endo S, Sugiyama Y, Niki T.
    Pathol Int Nov. 2015
  • The role of HGF/MET and FGF/FGFR in fibroblast-derived growth stimulation and lapatinib-resistance of esophageal squamous cell carcinoma.
    Saito S, Morishima K, Ui T, Hoshino H, Matsubara D, Ishikawa S, Aburatani H, Fukayama M, Hosoya Y, Sata N, Lefor AK, Yasuda Y, Niki T.
    BMC cancer Feb. 2015
  • Crohn's disease presenting as a ceco-urachal fistula.
    Hidenori Tsukui, Koinuma K, Morimoto M, Horie H, Lefor AK, Kagaya Y, Takahashi H, Yano T, Matsubara D, Yamamoto H, Sata N.
    Clinical Journal of Gastroenterology Oct. 2016
  • Cytoplasmic localization of p63 is associated with poor patient survival in lung adenocarcinoma.
    Narahashi T, Niki T, Wang T, Goto A, Matsubara D, Funata N, Fukayama M.
    Histopathology 49(4) 349-357 Oct. 2006
  • Establishment of Highly Metastatic KRAS Mutant Lung Cancer Cell Sublines by Long-term Three-dimensional Low Attachment Culture.
    Tomoyuki Nakano, Yoshihiko Kanai, Tomoko Tamura, Sachiko Oguni, Yusuke Amano, Taichiro Yoshimoto, Daisuke Matsubara, Takeshi Ito, Yoshinori Murakami, Masashi Fukayama, Takashi Murakami, Shunsuke Endo, and Toshiro Niki.
    PLoS One 2017
  • Inactivating mutations and hypermethylation of the NKX2-1/TTF-1 gene in non-TRU-type lung adenocarcinomas.
    Daisuke Matsubara, Manabu Soda, Taichiro Yoshimoto, Yusuke Amano, Yuji Sakuma, Azusa Yamato, Toshihide Ueno, Shinya Kojima, Tomoki Shibano, Yasuyuki Hosono4, Masahito Kawazu, Yoshihiro Yamashita, Shunsuke Endo, Koichi Hagiwara, Masashi Fukayama, Takashi Takahashi, Hiroyuki Mano, Toshiro Niki.
    Cancer Science 2017

Conference Presentations

  • Molecular and phenotypic diversity of lung adenocarcinomas
    Daisuke Matsubara
    The 14th Nikko International Symposium 2017 Molecular Target Therapy and Diagnostics 27 Oct. 2017
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Conference Presentationsclose
  • Molecular and phenotypic diversity of lung adenocarcinomas
    Daisuke Matsubara
    The 14th Nikko International Symposium 2017 Molecular Target Therapy and Diagnostics 27 Oct. 2017

Book

  • Differential diagnoses of lung metastases of unknown primary
    Daisuke Matsubara(Single Work )
    Feb. 2017
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  • Differential diagnoses of lung metastases of unknown primary
    Daisuke Matsubara(Single Work )
    Feb. 2017

Outside Fund Adoption

  • Molecular targets for lung adenocarcinoma with epithelial-mesenchymal transition : identification and their application for diagnosis and therapy.
    Ministry of Education, Culture, Sports, Science and Technology:Grants-in-Aid for Scientific Research(基盤研究(B))
    Project Year :2008 - 2012 Investigator(s) : Toshiro NIKI
  • Functional analysis of amplification and overexpression of c-Met in lung adenocarcinoma
    Ministry of Education, Culture, Sports, Science and Technology:Grants-in-Aid for Scientific Research(若手研究(B))
    Project Year :2009 - 2010 Investigator(s) : Daisuke MATSUBARA
  • Physiological and pathological analyses of cell adhesion molecules towards the development of diagnostic markers of human cancer
    Ministry of Education, Culture, Sports, Science and Technology:Grants-in-Aid for Scientific Research(基盤研究(B))
    Project Year :2010 - 2012 Investigator(s) : Yoshinori MURAKAMI
  • Chromatin Remodeling Factors Correlate with Epithelial-Mesenchymal Transition of Lung adenocarcinoma
    Ministry of Education, Culture, Sports, Science and Technology:Grants-in-Aid for Scientific Research(若手研究(B))
    Project Year :2011 - 2012 Investigator(s) : Daisuke MATSUBARA
  • Identification of molecular target and its therapeutic application for micropapillary adenocarcinoma
    Ministry of Education, Culture, Sports, Science and Technology:Grants-in-Aid for Scientific Research(挑戦的萌芽研究)
    Project Year :2011 - 2012 Investigator(s) : Toshiro NIKI
Display all
Outside Fund Adoptionclose
  • Molecular targets for lung adenocarcinoma with epithelial-mesenchymal transition : identification and their application for diagnosis and therapy.
    Ministry of Education, Culture, Sports, Science and Technology:Grants-in-Aid for Scientific Research(基盤研究(B))
    Project Year :2008 - 2012 Investigator(s) : Toshiro NIKI
  • Functional analysis of amplification and overexpression of c-Met in lung adenocarcinoma
    Ministry of Education, Culture, Sports, Science and Technology:Grants-in-Aid for Scientific Research(若手研究(B))
    Project Year :2009 - 2010 Investigator(s) : Daisuke MATSUBARA
  • Physiological and pathological analyses of cell adhesion molecules towards the development of diagnostic markers of human cancer
    Ministry of Education, Culture, Sports, Science and Technology:Grants-in-Aid for Scientific Research(基盤研究(B))
    Project Year :2010 - 2012 Investigator(s) : Yoshinori MURAKAMI
  • Chromatin Remodeling Factors Correlate with Epithelial-Mesenchymal Transition of Lung adenocarcinoma
    Ministry of Education, Culture, Sports, Science and Technology:Grants-in-Aid for Scientific Research(若手研究(B))
    Project Year :2011 - 2012 Investigator(s) : Daisuke MATSUBARA
  • Identification of molecular target and its therapeutic application for micropapillary adenocarcinoma
    Ministry of Education, Culture, Sports, Science and Technology:Grants-in-Aid for Scientific Research(挑戦的萌芽研究)
    Project Year :2011 - 2012 Investigator(s) : Toshiro NIKI


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