Researchers Database

komori takahiro

    DivisionofCardiovascularMedicine,DepartmentofMedicine Assistant Professor
Last Updated :2021/10/17

Researcher Information

URL

J-Global ID

Research Interests

  • 24時間血圧測定   心不全   テロメア長   生活習慣病   細胞老化   血管内皮機能   

Research Areas

  • Life sciences / Cardiology

Academic & Professional Experience

  • 2010 - 2011  Jichi Medical UniversitySchool of Medicine助教

Published Papers

  • Takahiro Komori, Satoshi Hoshide, Ken-Ichi Tabei, Hidekazu Tomimoto, Kazuomi Kario
    Journal of clinical hypertension (Greenwich, Conn.) 23 (5) 1089 - 1092 2021/05 
    White matter hyperintensities (WMHs) are risk factors for future cognitive impairment and are associated with an abnormal circadian blood pressure (BP) rhythm in patients with hypertension. However, whether this association exists in patients with heart failure (HF) is unclear. We performed a cross-sectional study of hospitalized patients with HF who underwent ambulatory BP monitoring and brain magnetic resonance imaging (MRI). A non-dipper BP pattern was defined as a < 10% nocturnal BP decline. WMHs on brain MRI scans were quantitated using a novel image analysis software (FUSION: FUsed Software for Imaging Of Nervous system). We enrolled 28 hospitalized patients with HF (age: 70.0 ± 9.8 years, 64.3% men). In the brain MRI analysis, the non-dipper group had higher WMH volume (18.9 ± 19.8 vs. 7.7 ± 8.3 mL, P = .047) and percentage of WMH/total brain volume (1.31 ± 1.28% vs. 0.55 ± 0.58%, P = .04) than the dipper group. In conclusion, using the newly developed MRI analysis software, we successfully quantitatively measured the volume of WMHs and found that the WMH volume increased 2.4 times in patients with a non-dipper pattern of nocturnal BP compared with those with a normal dipper pattern.
  • Takahiro Komori, Satoshi Hoshide, Kazuomi Kario
    Circulation journal : official journal of the Japanese Circulation Society 2021/04 
    BACKGROUND: Rising blood pressure (BP) in the morning, known as the morning BP surge (MBPS), is known to pose a risk for cardiovascular events in hypertensive individuals. It was not known whether the MBPS was associated with a worse prognosis in patients with heart failure (HF) with a reduced (HFrEF) or preserved (HFpEF) ejection fraction.Methods and Results:We performed a prospective, observational cohort study of hospitalized HF patients who underwent ambulatory BP monitoring (ABPM). The MBPS was calculated by subtracting the mean systolic BP (SBP) during the 1 h that included the lowest sleep BP from the mean SBP during the 2 h after waking. The MBPS group was defined as the top decile of MBPS (>40 mmHg). In all, 456 hospitalized HF patients (mean [±SD] age 68±13 years, 63.9% male) were followed-up for a median of 1.67 years. There were 90 events (16.3 per 100 person-years) of the composite outcome (all-cause mortality and worsening HF) in the HFrEF group, compared with 53 events (19.6 per 100 person-years) in the HFpEF group. Multivariate Cox regression analysis showed that MBPS was a significant predictor of outcome (hazard ratio 2.84, 95% confidence interval 1.58-5.10, P<0.01) in the HFrEF but not HFpEF group. CONCLUSIONS: MBPS was found to be a novel predictor of worsening HF in patients with HFrEF.
  • Miguel Camafort-Babkowski, Akintunde Adeseye, Antonio Coca, Albertino Damasceno, Giovanni De Simone, Maria Dorobantu, Pardeep S Jhund, Kazuomi Kario, Takahiro Komori, Hae Young Lee, Patricio López-Jaramillo, Okechukwu Ogah, Sandosh Padmanabahn, Domingo A Pascual-Figal, Wook Bum Pyun, Nicolás Federico Renna, Weimar Kunz Sebba Barroso, Osiris Valdez-Tiburcio, Fernando Stuardo Wyss-Quintana
    Journal of human hypertension 2020/11 
    Hypertension is a major risk factor for the development of heart failure with preserved ejection fraction (HFPEF) and blood pressure (BP) in itself is an important marker of prognosis. The association of BP levels, and hemodynamic parameters, measured by ambulatory blood pressure monitoring (ABPM), with outcomes, in patients with HFPEF is largely unknown. Patients with HFPEF have a substantial burden of co-morbidities and frailty. In addition there are marked geographic differences in HFPEF around the world. How these difference influence the association between BP and outcomes in HFPEF are unknown. The Global Ambulatory Blood Pressure Monitoring (ABPM) in Heart Failure with Preserved Ejection Fraction (HFpEF) Registry aims to assess the relevance of BP parameters, measured by ABPM, on the outcome of HFPEF patients worldwide. Additionally, the influence of other relevant factors such as frailty and co-morbidities will be assessed. Stable HFPEF patients with a previous hospitalization, will be included. Patients should be clinically and hemodynamically stable for at least 4 weeks before study inclusion. Specific data related to HF, biochemical markers, ECG and echocardiography will be collected. An ABPM and geriatric and frailty evaluation will be performed and the association with morbidity and mortality assessed. Follow up will be at least one year.
  • Praew Kotruchin, Satoshi Hoshide, Hiromi Ueno, Hayato Shimizu, Takahiro Komori, Kazuomi Kario
    Circulation journal : official journal of the Japanese Circulation Society 84 (9) 1544 - 1551 2020/08 
    BACKGROUND: Determinants of poor outcome in atherosclerotic cardiovascular disease (ASCVD) according to left ventricular ejection fraction (LVEF) are unclear. The renal resistive index (RRI) correlates well with atherosclerotic vascular damage, which, in turn, is correlated with cardiovascular outcomes. This study investigated whether high RRI is associated with poor cardiovascular outcomes in ASCVD patients classified by LVEF.Methods and Results:Records of 1,598 acute coronary syndromes (ACS) and acute decompensated heart failure (ADHF) patients, categorized into preserved (p), mid-range (mr), and reduced (r) ejection fraction (EF) groups (EF ≥50% [n=1,130], 40-50% [n=223], and <40% [n=245], respectively), were analyzed retrospectively. The primary endpoint was any cardiovascular-related event: fatal and non-fatal ACS, ADHF, stroke, and sudden cardiac death. Over 1.9-years follow-up (3,030 person-years), 233 events occurred: 122, 37, and 74 in the pEF, mrEF, and rEF groups, respectively. Adjusted Cox regression analysis revealed RRI ≥0.8 was associated with the primary endpoint in the pEF group (hazard ratio [HR] 1.67; 95% confidence interval [CI] 1.09-2.56), but not in the mrEF or rEF groups. The primary endpoint risk of pEF patients with an RRI ≥0.8 was comparable to that of mrEF patients using the pEF+RRI <0.8 group as the reference (HR 1.89 [95% CI 1.26-2.83] and 1.77 [95% CI 1.19-2.63], respectively). CONCLUSIONS: RRI was associated with the risk of cardiovascular events in ASCVD patients with pEF.
  • Praew Kotruchin, Satoshi Hoshide, Hiromi Ueno, Takahiro Komori, Kazuomi Kario
    American journal of hypertension 32 (4) 365 - 374 2019/03 
    BACKGROUND: The threshold of blood pressure (BP) reduction in cardiovascular patients is debatable due to the J-shaped curve phenomenon, which is particularly observed in patients with increased arterial stiffness. The renal resistive index (RRI) correlates well with systemic arterial stiffness; therefore, we aimed to demonstrate the role of RRI in guiding the choice of optimal BP. METHODS: A retrospective analysis of prospectively collected data of the hospitalized cardiovascular patients at Jichi Medical University Hospital. All patients had the RRI measurement performed and were assigned to a higher (RRI ≥ 0.8) or lower RRI group. Each group was subdivided by quartiles of the BP at discharge. The primary endpoints were fatal and nonfatal cardiovascular events, including heart failure, acute coronary syndrome, acute aortic disease, acute arterial occlusion, and stroke. RESULTS: The mean follow-up period was 1.9 years (3,365 person-years), n = 1,777 (mean age 64.7 years). There were 252 cardiovascular events occurred, 24.0% and 12.2% in the higher and lower RRI populations, P < 0.001. In the higher RRI group, the lowest systolic BP (SBP) quartile (<105 mm Hg) was a risk factor for cardiovascular events when compared with the highest SBP quartile (≥130 mm Hg; adjusted hazard ratio, 2.42; 95% confidence interval, 1.17-5.03; P = 0.017). A 1 SD decrease of SBP (17.5 mm Hg) was associated with a 25% increase in the risk of cardiovascular events. In the lower RRI group, these associations were not observed. CONCLUSIONS: Lower SBP at discharge was associated with a risk of cardiovascular events in the hospitalized cardiovascular patients with RRI ≥ 0.8.
  • Norihiko Kotooka, Masafumi Kitakaze, Kengo Nagashima, Machiko Asaka, Yoshiharu Kinugasa, Kotaro Nochioka, Atsushi Mizuno, Daisuke Nagatomo, Daigo Mine, Yoko Yamada, Akiko Kuratomi, Norihiro Okada, Daisuke Fujimatsu, So Kuwahata, Shigeru Toyoda, Shin-Ichi Hirotani, Takahiro Komori, Kazuo Eguchi, Kazuomi Kario, Takayuki Inomata, Kaoru Sugi, Kazuhiro Yamamoto, Hiroyuki Tsutsui, Tohru Masuyama, Hiroaki Shimokawa, Shin-Ichi Momomura, Yoshihiko Seino, Yasunori Sato, Teruo Inoue, Koichi Node
    Heart and vessels 33 (8) 866 - 876 2018/08 
    Home telemonitoring is becoming more important to home medical care for patients with heart failure. Since there are no data on home telemonitoring for Japanese patients with heart failure, we investigated its effect on cardiovascular outcomes. The HOMES-HF study was the first multicenter, open-label, randomized, controlled trial (RCT) to elucidate the effectiveness of home telemonitoring of physiological data, such as body weight, blood pressure, and pulse rate, for Japanese patients with heart failure (UMIN Clinical Trials Registry 000006839). The primary end-point was a composite of all-cause death or rehospitalization due to worsening heart failure. We analyzed 181 recently hospitalized patients with heart failure who were randomly assigned to a telemonitoring group (n = 90) or a usual care group (n = 91). The mean follow-up period was 15 (range 0-31) months. There was no statistically significant difference in the primary end-point between groups [hazard ratio (HR), 0.95; 95% confidence interval (CI), 0.548-1.648; p = 0.572]. Home telemonitoring for Japanese patients with heart failure was feasible; however, beneficial effects in addition to those of usual care were not demonstrated. Further investigation of more patients with severe heart failure, participation of home medical care providers, and use of a more integrated home telemonitoring system emphasizing communication as well as monitoring of symptoms and physiological data are required.
  • Taki M, Ishiyama Y, Mizuno H, Komori T, Kono K, Hoshide S, Kario K
    Circulation journal : official journal of the Japanese Circulation Society 82 (8) 2096 - 2102 1346-9843 2018/07 [Refereed][Not invited]
  • Hoshide S, Komori T, Ogata Y, Eguchi K, Kario K
    Pulse (Basel, Switzerland) 6 (1-2) 98 - 102 2235-8676 2018/07 [Refereed][Not invited]
  • Kazuo Eguchi, Takahiro Komori, Toshinobu Saito, Satoshi Hoshide, Kazuomi Kario
    Journal of Electrocardiology 51 (1) 21 - 26 1532-8430 2018/01 [Refereed][Not invited]
     
    Background We tested the hypothesis that an alpha-glucosidase inhibitor (α-GI), miglitol, is effective in protecting the cardiovascular system in type 2 diabetes mellitus (T2DM). Methods We studied 19 hospitalized heart disease patients with T2DM in whom we performed continuous glucose monitoring, Holter electrocardiogram, and ambulatory blood pressure (BP) monitoring simultaneously for 48 h. The α-GI miglitol was administered for half of the study period by a cross-over fashion. T-wave alternans (TWA), a marker of future fatal arrhythmic events, was also analyzed by Holter ECG. Results Of the 19 patients, the measures of glucose variability were significantly lower during miglitol therapy than in control period. BP variability was similar with/without miglitol. However, TWA was significantly lower during the miglitol period compared to control period (63 ± 4.8 vs. 75.8 ± 5.1 μV, p = 0.032). Conclusion An α-GI, miglitol, can reduce TWA by reducing the fluctuation of glucose in heart disease patients with T2DM.
  • Oba Y, Hoshide S, Mitama T, Shinohara H, Komori T, Kabutoya T, Imai Y, Ogata N, Kario K
    International heart journal 58 (6) 988 - 992 1349-2365 2017/12 [Refereed][Not invited]
  • 渡部 智紀, 甲谷 友幸, 渡辺 裕昭, 佐藤 彰洋, 小森 孝洋, 今井 靖, 三橋 武司, 苅尾 七臣
    心臓 (公財)日本心臓財団 49 (2) 103  0586-4488 2017/02 [Not refereed][Not invited]
     
    背景:Brugada症候群における心室性不整脈イベントにおいて就寝中や食後などの副交感神経活性との関連性が示唆されている。しかしながら不整脈発生時の状況およびtriggerとなる生活要因に関して、いまだ不明な点も多い。われわれはBrugada症候群における不整脈イベントの発生状況を検討した。方法:当院で植込み型除細動器(ICD)植込み術を施行したBrugada症候群連続32例を対象にICD適切作動を認めた患者背景を検討した。心室性不整脈に対しての適切動作を起こした9例と作動のなかった23例を比較検討した。ICD植込み前を含め心室性不整脈のみられた11例においてイベント発生時の血清カリウム値の関連について検討した。結果:適切作動と習慣性飲酒の関連性について検討した結果、適切作動群において有意に習慣性飲酒を多く認めた(適切作動群89%vs非作動群35%、p=0.002)。適切作動イベントに関す
  • Takahiro Komori, Kazuo Eguchi, Toshinobu Saito, Satoshi Hoshide, Kazuomi Kario
    Circulation journal : official journal of the Japanese Circulation Society 81 (2) 220 - 226 1347-4820 2017/01 [Refereed][Not invited]
     
    BACKGROUND: The cardiovascular prognosis of heart failure with preserved ejection fraction (HFpEF) has been shown to be similar to that of heart failure with reduced ejection fraction (HFrEF). It is unknown which factors predict cardiovascular outcome in HFpEF. We tested the hypothesis that the abnormal pattern of circadian blood pressure (BP) rhythm known as the riser BP pattern is associated with adverse outcomes in HFpEF.Methods and Results:We performed a prospective, observational cohort study of hospitalized HF patients who underwent ambulatory BP monitoring (ABPM). Five hundred and sixteen hospitalized HF patients (age, 69±13 years; male, n=321 [62%]; female, n=195 [38%]) were followed up for a median 20.9 months. The composite outcome consisting of all-cause mortality and cardiovascular events was observed in 220 patients. On Kaplan-Meier analysis, the riser BP pattern subgroup had a significantly higher incidence of the composite outcome than the other subgroups of HFpEF patients (HR, 3.01; 95% CI: 1.54-6.08, P<0.01), but not the HFrEF patients. CONCLUSIONS: The riser BP pattern was found to be a novel predictor of cardiovascular outcome in HFpEF patients.
  • Takahiro Komori, Kazuo Eguchi, Toshinobu Saito, Satoshi Hoshide, Kazuomi Kario
    Journal of clinical hypertension (Greenwich, Conn.) 18 (10) 994 - 999 1524-6175 2016/10 [Refereed][Not invited]
     
    Paradoxical increase in blood pressure (BP) during sleep, exceeding those of awake BP, is called the "riser" BP pattern, and known as an abnormal circadian BP rhythm, has been reported to be associated with adverse cardiovascular prognoses. However, the significance of ambulatory BP in heart failure patients with preserved ejection fraction (HFpEF) has never been reported. Here, we tested our hypothesis that abnormal circadian BP rhythm is associated with HFpEF. The authors enrolled 508 patients with hospitalized HF (age 68±13 years; 315 men, 193 women). There were 232 cases of HFpEF and 276 cases of heart failure with reduced ejection fraction (HFrEF). The riser BP pattern was significantly more frequent in the HFpEF (28.9%) group compared with the HFrEF group (19.9%). In a multivariable logistic regression analysis, the riser BP pattern was associated with HFpEF (odds ratio, 1.73; 95% confidence interval, 1.02-2.91; P=.041) independent of the other covariates. In conclusion, the riser BP pattern was associated with HFpEF.
  • Takahiro Komori, Kazuo Eguchi, Kazuomi Kario
    HYPERTENSION RESEARCH 39 (9) 631 - 632 0916-9636 2016/09 [Refereed][Not invited]
  • 青山 泰, 大場 祐輔, 小森 孝洋, 甲谷 友幸, 星出 聡, 苅尾 七臣
    日本内科学会関東地方会 日本内科学会-関東地方会 624回 27  2016/06 [Not refereed][Not invited]
  • Takahiro Komori, Kazuo Eguchi, Toshinobu Saito, Yoshioki Nishimura, Satoshi Hoshide, Kazuomi Kario
    American journal of hypertension 29 (2) 194 - 201 0895-7061 2016/02 [Refereed][Not invited]
     
    BACKGROUND: The riser pattern, an abnormal blood pressure (BP) rhythm in which sleep BP exceeds awake BP, is a predictor of future stroke events. Although the riser pattern is caused by autonomic dysfunction, its significance in heart failure (HF) patients is not established. HF patients often suffered from cognitive impairment (CI), but the relationship between riser pattern and CI is not clearly understood. We tested the hypothesis that the riser pattern is associated with mild CI, a form of brain damage that could develop to dementia. METHODS: We performed Mini-Mental State Examination (MMSE), ambulatory BP monitoring (ABPM), echocardiography, and blood tests in 444 HF patients just before leaving hospitals. Mild CI, a measure of cognitive function, was defined as the score <26. RESULTS: The mean age of the patients was 68±13 years; 61.5% were male; 22.5% were riser pattern. The MMSE score was significantly lower in the Riser group than in the Non-dipper and Dipper group (23±4 vs. 25±5, 26±4, respectively, P < 0.01). In multivariable logistic regression analysis, a riser pattern was significantly associated with mild CI (odds ratio 2.38, 95% confidence intervals 1.29-4.42, P < 0.01) after adjusting for significant covariates. CONCLUSIONS: The riser pattern was associated with mild CI in HF patients. An abnormal circadian BP rhythm in HF patients is clinically significant as a potential indicator of subclinical brain damage.
  • Tomoyuki Kabutoya, Yasushi Imai, Hiroaki Watanabe, Tomonori Watanabe, Takahiro Komori, Kazuomi Kario
    International Heart Journal 57 (1) 118 - 120 1349-3299 2016/01 [Refereed][Not invited]
     
    48-year-old woman underwent cardiac resynchronization therapy defibrillator implantation. Coronary sinus (CS) venography showed only one adequate anterior branch for a left ventricular lead. We were able to introduce a quadripolar left ventricular lead (Medtronic 4398-88 cm) to the distal portion of the anterior branch. Although phrenic nerve stimulation (PNS) occurred due to distal bipolar pacing (distal 1–mid 2, with 21-mm distance) and proximal pacing (mid 3–proximal 4, distance 21mm), short-spaced bipolar pacing (mid 2-3, distance 1.3 mm) did not induce PNS until 9V pacing. Shared bipolar pacing from each left ventricular electrode (distal 1 to proximal 4) as cathode and a right ventricular (RV) coil as anode resulted in PNS by 3.0V at 0.4 ms. Although quadripolar pacing could avoid PNS by switching the pacing site (ie, from distal bipolar to proximal bipolar), it might not avoid PNS in cases where the phrenic nerve and CS branch are parallel and in close proximity. We found that even though the phrenic nerve and CS branch were parallel and close, short-spaced bipolar pacing could avoid PNS. In conclusion, short-spaced bipolar pacing selected by quadripolar pacing might be beneficial to avoid PNS when the implantable branch is limited.
  • Kazuo Eguchi, Satoshi Hoshide, Takahiro Komori, Shoichiro Nagasaka, Kazuomi Kario
    AMERICAN JOURNAL OF HYPERTENSION 28 (8) 971 - 979 0895-7061 2015/08 [Refereed][Not invited]
     
    OBJECTIVE The target levels of home-monitored blood pressure (BP) in patients with type 2 diabetes mellitus (T2DM) have not yet been established. We sought to examine the appropriate target home BP level in T2DM. METHODS This is a subanalysis of the Japan Morning Surge-Home Blood Pressure (J-HOP) study. We enrolled 4,310 patients who had at least 1 cardiovascular risk factor, and clinic and home BP monitoring was performed. The urinary albumin-to-creatinine ratio (UACR) was measured as a marker of microvascular disease. Quadratic equations of the relationship between clinic/home systolic BP (SBP) and log-transformed UACR were used to determine the home BP value. Home BP levels corresponding to clinic SBP/diastolic BP (DBP) level using the UACR values were calculated separately by the presence/absence of diabetes. RESULTS The mean age of the patients was 64.9 +/- 10.9 years; 47.0% were males. Of the 4,310 subjects enrolled, 1,057 (24.5%) had T2DM (the DM group) and 3,253 (75.5%) did not (non-DM group). The home BP levels equivalent to clinic BP 140/90 mm Hg were 135/84 and 135/83 mm Hg in the DM and non-DM groups, respectively. The home SBP levels equivalent to clinic SBP 130/80 mm Hg were 122/79 mm Hg in the non-DM group and 129/78 mm Hg in the DM group. CONCLUSIONS Regardless of diabetic status, the home BP level that corresponds to the clinic SBP 140/90 mm Hg was 135/85 mm Hg. In patients with T2DM, the home SBP level equivalent to clinic SBP 130/80 mm Hg was 129/78 mm Hg with regard to the extent of microvascular disease.
  • Takahiro Komori, Kazuo Eguchi, Tomoyuki Kabutoya, Joji Ishikawa, Satoshi Hoshide, Kazuomi Kario
    CLINICAL AND EXPERIMENTAL HYPERTENSION 36 (8) 538 - 544 1064-1963 2014 [Refereed][Not invited]
     
    Background: Masked uncontrolled hypertension (MUH), defined as controlled office blood pressure (BP) but uncontrolled out-of-office BP in treated hypertensives, is a risk factor for cardiovascular disease. We tested the hypothesis that MUH is associated with a greater degree of diastolic dysfunction than controlled hypertension (CH) or uncontrolled hypertension (UH). Methods and results: We studied 299 treated patients who had at least one cardiovascular risk factor (age, 63 +/- 10 years; male sex, 43%), consisting of 94 (31.4%) patients with UH, 46 (15.4%) with MUH, 56 (18.7%) with treated white-coat hypertension (WCH), and 103 (34.4%) with CH. We performed office and home BP monitoring, electrocardiography, echocardiography and blood tests. Diastolic dysfunction was defined as an E-wave to e'-wave (E/e') ratio >= 8 measured by Doppler echocardiography. The value of E/e' was higher in the MUH (8.3 +/- 2.7) and UH (8.3 +/- 2.7) groups than in the CH group (7.3 +/- 2.3; p +/- 0.08, p = 0.02, respectively). In multivariable analysis, MUH was associated with a significantly higher likelihood of diastolic dysfunction than CH (odds ratio 2.90 versus CH, p<0.01) after adjusting for significant covariates. Conclusions: MUH and UH were associated with a greater degree of diastolic dysfunction than CH. Even in treated patients, out-of-office BP is important to stratify the risk of cardiovascular disease.
  • Takahiro Komori, Kazuo Eguchi, Satoshi Hoshide, Bryan Williams, Kazuomi Kario
    BLOOD PRESSURE MONITORING 18 (1) 57 - 62 1359-5237 2013/02 [Refereed][Not invited]
     
    Objective(s) We compared a convenient, cuffless, wrist-type ambulatory blood pressure monitoring (ABPM) device (BPro) and a standard arm-type ABPM monitor under ambulatory conditions. Methods Fifty normotensive and prehypertensive volunteers who had no interarm differences in BP were enrolled. The wrist and arm monitors were attached to the left wrist and the right arm, respectively, and provided readouts at 15 and 30-min intervals, respectively. Ambulatory BP levels and the extent of agreement by intraclass correlation were evaluated. In 15 of the 50 participants, we also examined values at different arm positions: heart level, above the head, and hanging at the sides. Results The awake mean systolic blood pressure (SBP) values (122 +/- 13 vs. 127 +/- 11 mmHg, P < 0.01) were significantly lower with the wrist monitor than the arm monitor, and the mean sleep diastolic blood pressure (DBP) (71 +/- 8 vs. 64 +/- 8 mmHg, P < 0.01) was significantly higher with the wrist monitor than the arm monitor. The intraclass correlation values between the monitors were 0.54 for 24 h SBP and 0.52 for awake SBP, considered to indicate a moderate agreement. The BP values in the arm-raised position were significantly higher for the wrist monitor than for the arm monitor (SBP: 129 +/- 14 vs. 108 +/- 14 mmHg, P < 0.01; DBP: 83 +/- 13 vs. 64 +/- 11 mmHg, P < 0.01). However, the SBP and DBP values in the other arm positions were similar between the monitors. Conclusion The wrist monitor showed fair agreement with the arm monitor in the ambulatory condition, and was stable irrespective of arm positions. Blood Press Monit 18:57-62 (C) 2013 Wolters Kluwer Health vertical bar Lippincott Williams & Wilkins. Blood Pressure Monitoring 2013, 18:57-62
  • Masaru Ichida, Kenichi Katsurada, Takahiro Komori, Jun Matsumoto, Akihide Ohkuchi, Akio Izumi, Shigeki Matsubara, Takeshi Mitsuhashi, Kazuomi Kario
    Journal of cardiology cases 2 (1) e28-e31  2010/08 
    Peripartum cardiomyopathy (PPCM) is a rare but potentially life-threatening disorder that occurs in late pregnancy or the early puerperium despite optimal medical therapy. Recently, oxidative stress-mediated generation of antiangiogenic and proapoptotic 16-kDa prolactin, and subsequent impaired cardiac microvascularization have been related to PPCM. In turn, prolactin blockade with bromocriptine has been proven successful in preventing the onset of PPCM in mice and in patients at high risk for the disease. Here, we report the efficacy of bromocriptine for treatment of a patient with PPCM.
  • Komori T, Shimada K
    Nihon rinsho. Japanese journal of clinical medicine 8 66 1446 - 1448 0047-1852 2008/08 [Refereed][Not invited]
  • Takahiro Komori, Kazuo Eguchi, Hidenori Tomizawa, Joji Ishikawa, Satoshi Hoshide, Kazuyuki Shimada, Kazuomi Kario
    Hypertension research : official journal of the Japanese Society of Hypertension 31 (2) 289 - 94 0916-9636 2008/02 [Refereed][Not invited]
     
    Stroke is sometimes seen in patients with congestive heart failure (CHF). The factors that best predict incident stroke in hospitalized CHF patients are not well known. We performed this pilot study to explore the clinical markers of incident stroke in CHF patients. We studied 111 hospitalized patients with CHF (mean age, 67+/-11 years). Ambulatory blood pressure (BP) monitoring, blood tests, and echocardiography were performed in these patients just before they left the hospital, and all cardiovascular events during the study period were followed for an average of 18+/-9 months. Cox regression analysis was performed to explore the predictors of incident stroke using age, sex, body mass index (BMI), casual and ambulatory systolic BP (SBP), and brain-type natriuretic peptide (BNP). There were 10 stroke events (9%) during the follow-up period. The stroke group had higher nocturnal SBP and plasma BNP levels than the non-stroke group. With Cox regression analysis, both nocturnal SBP and BNP were significant predictors of incident stroke independent of other covariates. When nocturnal BP of 120 mmHg and BNP of 600 pg/mL (75th percentile) were used as cutoffs, nocturnal SBP > or =120 mmHg was associated with a 7-fold increase in the risk of incident stroke, while BNP > or =600 pg/mL was associated with a 46.6-fold increase. However, abnormal circadian BP patterns were not associated with incident stroke. In this pilot study, elevated nocturnal BP and high plasma BNP just before patients left the hospital were significant predictors of stroke events in CHF patients. Further study is needed to confirm this hypothesis.

MISC

  • ペースメーカーからCRTへのアップグレード症例のQRS幅の変化の検討
    奥山 貴文, 甲谷 友幸, 横田 彩子, 小森 孝洋, 今井 靖, 苅尾 七臣  日本心臓病学会学術集会抄録  65回-  P  -267  2017/09  [Not refereed][Not invited]
  • Takahiro Komori, Kazuo Eguchi, Toshinobu Saito, Satoshi Hoshide, Kazuomi Kario  CIRCULATION  134-  2016/11  [Not refereed][Not invited]
  • Takahiro Komori, Kazuo Eguchi, Toshinobu Saito, Satoshi Hoshide, Kazuomi Kario  CIRCULATION  134-  2016/11  [Not refereed][Not invited]
  • 潰瘍性大腸炎に合併した肺動脈性肺高血圧症の一例
    奥山 貴文, 石山 裕介, 金子 大介, 一井 直樹, 小森 孝洋, 今井 靖, 苅尾 七臣  日本心臓病学会学術集会抄録  64回-  P  -165  2016/09  [Not refereed][Not invited]
  • 初診時に巨大陰性T波を認めた若年の特発性心室頻拍の1例
    有馬 生悟, 甲谷 友幸, 小森 孝洋, 今井 靖, 苅尾 七臣  日本心臓病学会学術集会抄録  64回-  P  -529  2016/09  [Not refereed][Not invited]
  • 滝 瑞里, 小森 孝洋, 今井 靖, 苅尾 七臣, 河田 政明  循環器専門医  24-  (1)  116  -122  2016/02  [Not refereed][Not invited]
     
    症例は68歳女性で、小学6年時に健診で雑音を指摘されたが経済的理由で精査をしなかった。問題なく運動は可能で、同年代と比べ息切れしやすい自覚もなかった。60歳頃から下腿浮腫、口唇チアノーゼを認め、入院半年前から、徐々に労作性息切れ、下腿浮腫増悪を自覚して受診し、心不全の診断で入院した。意識レベルJCS0、血圧164/77mmHg、心拍数76拍/分・整、呼吸数16回/分、体温37.1℃、経皮的酸素飽和度(自発呼吸、酸素鼻カヌラ4L/分)82%であった。眼瞼結膜に貧血なく、眼球結膜に黄疸なく、顔面浮腫あり、頸静脈怒張ありであった。心音不整、IIp音亢進、頸部への放散を伴わない胸骨左縁第3肋間を最強点とするLevine III/IVの収縮期駆出性雑音を聴取し、呼吸音は両側で減弱していた。入院時検査から重症肺動脈弁狭窄症および三尖弁狭窄兼閉鎖不全症による慢性心不全の急性増悪、および心拡大に伴う肺容積減少によるII型呼吸不全と診断し、フロセミド、ドパミン静注を開始し、NIPPV装着を行った。NIPPVはBiPAPモードで、IPAP/EPAP 8/4mmHg、FiO2 1.0の設定で経皮的酸素濃度90%前半をどうにか維持できた。治療開始後、利尿反応は良好で、約1週間で体重は3kg減少し、下腿浮腫は消失した。酸素化の改善は乏しかったためスピロノラクトン25mg/日内服を追加しさらに利尿を図ったが、低拍出量症候群となり腎機能障害の悪化、肝機能障害の出現を認めた。内科的治療は限界と判断し、外科手術しかないと考え、患者も希望したため、第58病日に手術を行った。術後1日目には抜管でき、その後内服調整、リハビリを行い全身状態が徐々に改善した。第82病日、酸素投与なしで経皮的酸素濃度95%前後を保てるようになり、独歩で退院し、外来通院中である。
  • 先天性心疾患術後・下大静脈欠損に合併した心房粗動に対するカテーテルアブレーション
    今井 靖, 渡邉 裕昭, 甲谷 友幸, 渡部 智紀, 小森 孝洋, 久保田 香菜, 佐藤 彰洋, 佐藤 智幸, 片岡 功一, 南 孝臣, 河田 政明, 苅尾 七臣  日本成人先天性心疾患学会雑誌  5-  (1)  123  -123  2016/01  [Not refereed][Not invited]
  • 高齢になって自覚症状が出現し手術に至った先天性肺動脈二尖弁の一例
    滝 瑞里, 小森 孝洋, 今井 靖, 新保 昌久, 苅尾 七臣, 河田 政明  日本心臓病学会学術集会抄録  63回-  85  -85  2015/09  [Not refereed][Not invited]
  • 【循環器系の人工臓器】 ペースメーカーの最近の進歩
    渡邉 裕昭, 今井 靖, 小森 孝洋, 甲谷 友幸, 苅尾 七臣  医学と薬学  72-  (3)  405  -416  2015/02  [Not refereed][Not invited]
  • Takahiro Komori, Kazuo Eguchi, Yoshioki Nishimura, Masaru Ichida, Satoshi Hoshide, Kazuomi Kario  JOURNAL OF CARDIAC FAILURE  20-  (10)  S165  -S165  2014/10  [Not refereed][Not invited]
  • Masaru Ichida, Yoshioki Nishimura, Takahiro Komori, Kazuomi Kario  JOURNAL OF CARDIAC FAILURE  20-  (10)  S167  -S168  2014/10  [Not refereed][Not invited]
  • 妊娠高血圧症候群における出産前後の動脈スティフネスの検討
    福島 大史, 江口 和男, 小森 孝洋, 大口 昭英, 苅尾 七臣  日本動脈硬化学会総会プログラム・抄録集  46回-  314  -314  2014/06  [Not refereed][Not invited]
  • Takahiro Komori, Kazuo Eguchi, Toshinobu Saito, Satoshi Hoshide, Kazuomi Kario  JOURNAL OF CARDIAC FAILURE  19-  (10)  S157  -S157  2013/10  [Not refereed][Not invited]
  • 小森 孝洋  Circulation up-to-date  7-  (5)  508  -510  2012/10  [Not refereed][Not invited]
  • 小森孝洋, 苅尾七臣  循環器内科  72-  (1)  27  -34  2012/07  [Not refereed][Not invited]
  • 小森 孝洋, 苅尾 七臣  循環器内科  72-  (1)  27  -34  2012/07  [Not refereed][Not invited]
  • 小森 孝洋, 苅尾 七臣  Circulation up-to-date  7-  (2)  140  -146  2012/04  [Not refereed][Not invited]
  • 小森孝洋, 苅尾七臣  動脈硬化予防  9-  (4)  98  -101  2011/01  [Not refereed][Not invited]
  • 小森孝洋, 星出聡, 島田和幸  Prog Med  30-  (12)  3067  -3071  2010/12  [Not refereed][Not invited]
  • 小森孝洋, 苅尾七臣  Medicina  46-  (1)  130  -135  2009/01  [Not refereed][Not invited]
  • 小森 孝洋, 島田 和幸  Japanese journal of clinical medicine  66-  (8)  1446  -1448  2008/08  [Not refereed][Not invited]
  • Takahiro Komori, Kazuo Eguchi, Joji Ishikawa, Hidenori Tomizawa, Satoshi Hoshide, Kazuyuki Shimada, Kazuomi Kario  JOURNAL OF HYPERTENSION  24-  406  -406  2006/12  [Not refereed][Not invited]
  • 小森孝洋, 苅尾七臣  血液フロンティア  16-  (6)  903  -909  2006/05  [Not refereed][Not invited]


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