Researchers Database

nagashima shuuichi

    ComprehensiveMedicine1 Associate Professor
Last Updated :2021/10/20

Researcher Information

URL

Research funding number

  • 30406136

J-Global ID

Research Interests

  • 肝臓   コレステロール   肝障害   ノックアウト   ヒト   リポ蛋白リパーゼ   マウス   マクロファージ   アルブミン   インスリン抵抗性   肥満   HMG-CoA還元酵素   トリグリセリド   脂肪細胞   IMG-CoA還元酵素   動脈硬化   リパーゼ   脂肪酸   スクワレン合成酵素   遺伝子発現   

Research Areas

  • Life sciences / Metabolism and endocrinology
  • Life sciences / Gastroenterology

Academic & Professional Experience

  • 2020/10  自治医科大学附属さいたま医療センター内分泌代謝科准教授
  • 2015  自治医科大学内科学講座内分泌代謝学部門講師
  • 2014  Jichi Medical UniversitySchool of Medicine助教

Published Papers

  • Sakai, Kent, Nagashima, Shuichi, Wakabayashi, Tetsuji, Tumenbayar, Bayasgalan, Hayakawa, Hiroko, Hayakawa, Morisada, Karasawa, Tadayoshi, Ohashi, Ken, Yamazaki, Hisataka, Takei, Akihito, Takei, Shoko, Yamamuro, Daisuke, Takahashi, Manabu, Yagyu, Hiroaki, Osuga, Jun-ichi, Takahashi, Masafumi, Tominaga, Shin-ichi, Ishibashi, Shun
    ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY LIPPINCOTT WILLIAMS & WILKINS 38 (11) 2590 - 2600 1079-5642 2018/11 [Refereed][Not invited]
  • Shuichi Nagashima, Hiroaki Yagyu, Nirei Takahashi, Tomoyuki Kurashina, Manabu Takahashi, Takeshi Tsuchita, Fumiko Tazoe, Xiao Li Wang, Tumenbayar Bayasgalan, Naoko Sato, Kenta Okada, Shoichiro Nagasaka, Takaya Gotoh, Masayuki Kojima, Masanobu Hyodo, Hisanaga Horie, Yoshinori Hosoya, Masaki Okada, Yoshikazu Yasuda, Hiroyuki Fujiwara, Michitaka Ohwada, Sadahiko Iwamoto, Mitsuaki Suzuki, Hideo Nagai, Shun Ishibashi
    JOURNAL OF ATHEROSCLEROSIS AND THROMBOSIS 18 (3) 190 - 199 1340-3478 2011 [Refereed][Not invited]
     
    Aim: Adipocyte lipolysis is mediated by a family of triglyceride (TG) lipases consisting of hormone-sensitive lipase (LIPE), adipose triglyceride lipase (PNPLA2) and carboxylesterase 1 (CES1); however, little is known about the relationship between the expression of each gene in different depots and TG lipase activity or obesity Method: We measured both mRNA expression levels of the lipolytic enzymes (LIPE, PNPLA2 and CES1) and TG lipase activities of biopsy samples obtained from subcutaneous, omental and mesenteric adipose tissues of 34 patients who underwent abdominal surgery. The results were correlated with clinical parameters: adiposity measures, parameters for insulin resistance and plasma lipid levels. Results: PNPLA2 mRNA levels were slightly higher in omental fat than subcutaneous fat. Cytosolic TG lipase activities were positively correlated with the mRNA levels of CES1 in subcutaneous fat and mesenteric fat, while they were correlated with those of PNPLA2 in omental fat. The mRNA levels of LIPE were negatively correlated with various measures of adiposity in subcutaneous fat. The mRNA levels of CES1 were positively correlated with various measures of adiposity, particularly those estimated by CT in the three depots; they were also positively correlated with plasma LDL-cholesterol levels in omental fat. In contrast, the mRNA levels of PNPLA2 were not significantly associated with adiposity. Conclusions: The positive correlations of the expression of CES1 with cytosolic TG lipase activities as well as with adiposity suggest that CES1 is involved in lipolysis, thereby contributing to the development of obesity-associated phenotypes. On the other hand, the expression of LIPE is negatively correlated with adiposity. These distinct regulatory patterns of lipolytic genes may underlie the complex phenotypes associated with human obesity.
  • Motohiro Sekiya, Jun-Ichi Osuga, Shuichi Nagashima, Taichi Ohshiro, Masaki Igarashi, Hiroaki Okazaki, Manabu Takahashi, Fumiko Tazoe, Taeko Wada, Keisuke Ohta, Mikio Takanashi, Masayoshi Kumagai, Makiko Nishi, Satoru Takase, Naoya Yahagi, Hiroaki Yagyu, Ken Ohashi, Ryozo Nagai, Takashi Kadowaki, Yusuke Furukawa, Shun Ishibashi
    Cell metabolism 10 (3) 219 - 28 2009/09 
    Cholesterol ester (CE)-laden macrophage foam cells are the hallmark of atherosclerosis, and the hydrolysis of intracellular CE is one of the key steps in foam cell formation. Although hormone-sensitive lipase (LIPE) and cholesterol ester hydrolase (CEH), which is identical to carboxylsterase 1 (CES1, hCE1), were proposed to mediate the neutral CE hydrolase (nCEH) activity in macrophages, recent evidences have suggested the involvement of other enzymes. We have recently reported the identification of a candidate, neutral cholesterol ester hydrolase 1(Nceh1). Here we demonstrate that genetic ablation of Nceh1 promotes foam cell formation and the development of atherosclerosis in mice. We further demonstrate that Nceh1 and Lipe mediate a comparable degree of nCEH activity in macrophages and together account for most of the activity. Mice lacking both Nceh1 and Lipe aggravated atherosclerosis in an additive manner. Thus, Nceh1 is a promising target for the treatment of atherosclerosis.


Copyright © MEDIA FUSION Co.,Ltd. All rights reserved.