Researchers Database

kotani kazuhiko

    CenterforCommunityMedicineDivisionofCommunityandFamilyMedicine Professor
Last Updated :2021/11/22

Researcher Information


  • Doctor (medicine)(Jichi Medical University)


J-Global ID

Research Interests

  • Community medicine   Dyslipidemia   Clinical pathology   疫学   健康教育   メタボリックシンドローム   肥満   健康科学   予防医学   Epidemiology   Preventive Medicine   Metabolic syndrome   Obesity   Lipid   Hypercholesterolemia   Clinical Laboratory Medicine   

Research Areas

  • Life sciences / Healthcare management, medical sociology / Community medicine
  • Life sciences / Metabolism and endocrinology
  • Life sciences / Healthcare management, medical sociology
  • Life sciences / Hygiene and public health (non-laboratory)
  • Life sciences / Hygiene and public health (laboratory)
  • Life sciences / Hygiene and public health (non-laboratory)
  • Life sciences / Hygiene and public health (laboratory)
  • Life sciences / Healthcare management, medical sociology
  • Other / Other / Laboratory medicine

Association Memberships



  • 地域医療学に関する研究
  • 多職種連携の研究
  • 在宅臨床検査学の確立に関する研究
  • 家族性高コレステロール血症の研究
  • 高脂血症に関する分子遺伝学的研究
  • 糖尿病の外来診療の質を上げるテンプレート作成
  • 肥満の代謝ネットワーク研究
  • 耐糖能異常者の糖尿病移行に関する予防医学


  • Kazuhiko Kotani, Tokio Shimomura, Fumiyo Shimomura, Shiro Ikawa, Eiji Nanba  Headache  42-  (9)  893  -895  2002/10  [Not refereed][Not invited]
    Background. The serotonergic system has been thought to play an important part in the pathophysiology of migraine. Objective. To study an association between the polymorphism of serotonin (5-hydroxytryptamine [5-HT]) transporter gene-linked polymorphic region (5-HTTLPR) and migraine. Method. We compared 151 patients with migraine with 190 healthy unrelated control subjects. The 5-HTTLPR polymorphism was detected using polymerase chain reaction. Migraine patients were interviewed regarding attack frequency in the last 6 months. Results. We denoted the products of the 484-base pair (bp) fragments as the short (s) and those of 528 bp as the long (1) allele according to the previously reported manner. Migraine patients with s/s genotype were compared with those with l/s and l/l genotype. We did not find significant differences in the genotype and allele frequencies of 5-HTTLPR between patients with migraine and control subjects. Among patients with migraine, those with s/s type had significantly more frequent attacks than those with the l/s or l/l type. Conclusions. This polymorphism does not appear to be involved in a genetic predisposition to the disease but may affect the frequency of attacks in patients with migraine. These findings may contribute to our understanding of factors that influence the clinical severity of migraine.
  • Effects on immunologocal activity by short-term spa (hot spring) bathing
    Clinical chemistry and Laboratory Medicine  40-  (Suppl)  278  2002  [Not refereed][Not invited]
  • K Kotani, T Shimomura, F Murakami, S Ikawa, Y Kanaoka, S Ohgi, K Adachi, E Nanba  INTERNAL MEDICINE  39-  (7)  537  -539  2000/07  [Not refereed][Not invited]
    Objective This study was performed to examine the role of the endothelial constitutive NO synthase (ecNOS) gene in patients with abdominal aortic aneurysm (AAA), Methods We determined the distributions of polymorphism in intron 4 of the ecNOS (ecNOS4) gene, amplified by polymerase chain reaction, and compared the allele frequencies between subjects with abdominal aortic aneurysms (AAAs) and healthy individuals. Patients Fifty-eight patients with AAAs and 410 race-matched healthy controls were studied, Results Two alleles of the ecNOS4 gene, containing 4 (a-allele) and 5 (b-allele) repeats, were identified. We found that the a-allele frequency of this gene was significantly higher in the surgical than in the non-surgical group. Conclusion The results of this study suggest that the a-allele of the ecNOS4 gene is indicative of the need for surgery for AAA, Analysis of the alleles of the ecNOS4 gene polymorphism could provide useful information concerning the clinical course of AAA progression.
  • Cephalalgia  19-  (1)  218  -222  1999  [Not refereed][Not invited]
  • Fumiyo Murakami, Tokio Shimomura, Kazuhiko Kotani, Shiro Ikawa, Eiji Nanba, Kaori Adachi  Journal of Human Genetics  44-  (1)  15  -17  1999  [Not refereed][Not invited]
    We determined polymorphism in the s (5-HT) transporter gene-linked polymorphic re HTTLPR) in 501 healthy Japanese, individuals, u polymerase chain reaction of Lesch et al., with minor modifications. The distribution of allele frequencies was mined and found to differ from that in Caucasians. We also investigated the relationship of polymorphism HTTLPR to anxiety traits, by having 189 of the 501 complete a self-rating questionnaire for anxiety and depression. Subjects with the short/short (s/s) genotype had significantly higher anxiety scores than those with the k (l/l) or l/s genotype. It is suggested that populations s/s genotype of 5-HTTLPR have stronger anxiety personality traits than those with the 1 allele.

Awards & Honors

  • 2003 The resarch award of the Japan Clinical Chemistry

Research Grants & Projects

  • 酸化LDL
    Date (from‐to) : 2006 
  • 肥満とメタボリックシンドロームの健康教育と予防医学
    Date (from‐to) : 2006 
  • 家族性高コレステロール血症の病態解明と治療
    Date (from‐to) : 2006 
  • 高脂血症(脂質異常症)の検査
    Date (from‐to) : 2006 
  • Health education and patient education in obesity and metabolic syndrome
    Date (from‐to) : 2006 
    Establishment of health education and patient education in obesity and metabolic syndrome
  • Preventive medicine in obesity and metabolic syndrome
    Date (from‐to) : 2006 
    Establishment of preventive medicine in obesity and metabolic syndrome
  • Reserch on oxidative stress and oxidative LDL (low density lipoprotein)
    Date (from‐to) : 2006 
    Laboratory method and pathophysiology in oxidative stress and oxidative LDL
  • Familial cholesterolemia
    Date (from‐to) : 2006 
    Establishment of diagnosis aand treatment, including gene and its polymorphism, in familial hypercholesterolemia
  • Research on mechanism of hypercholesterolemia(dyslipidemia)
    Date (from‐to) : 2006 
    Establishment of diagnosis and treatment of hypercholestrolemia
  • Community medicine
    Ministry of Health, Labor and Welfare in Japan:Ministry of Health, Labor and Welfare in Japan

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