Researchers Database

takahashi hironori

    ObstetricsandGynecology Professor
Last Updated :2021/11/23

Researcher Information

URL

Research funding number

  • 80544303

ORCID ID

J-Global ID

Research Areas

  • Life sciences / Obstetrics and gynecology

Education

  • 2010/04 - 2014/03  Jichi Medical University  Medicine  医学研究科
  • 1994/04 - 2000/03  National Defense Medical College  Medicine  医学科

Association Memberships

  • THE JAPAN SOCIETY OF ULTRASONICS IN MEDICINE   THE JAPAN SOCIETY OF HUMAN GENETICS   日本胎盤学会   日本胎児治療学会   JAPAN SOCIETY OF PERINATAL AND NEONATAL MEDICINE   JAPAN SOCIETY OF OBSTETRICS AND GYNECOLOGY   

Published Papers

  • Keiko Kagawa, Hironori Takahashi, Shiho Nagayama, Kenji Horie, Kayo Takahashi, Yosuke Baba, Manabu Ogoyama, Hirotada Suzuki, Rie Usui, Akihide Ohkuchi, Shigeki Matsubara
    Taiwanese journal of obstetrics & gynecology 60 (5) 874 - 877 2021/09 
    OBJECTIVE: Cystic hygroma often ameliorates or disappears with pregnancy progression. Fetuses/neonates with amelioration, when without chromosomal or major structural abnormality, generally show a favorable outcome at birth. The present study was aimed to clarify the short/long-term outcomes of fetuses/neonates with the amelioration of cystic hygroma during pregnancy. MATERIAL AND METHODS: This was a retrospective observational study. We focused on fetuses with cystic hygroma managed in our institute between January 2006 and June 2019. The infants were followed by pediatricians (neonatologist, pediatric cardiologist, and pediatric neurologist) and pediatric outcomes were retrieved from the medical records up to 3 years old. RESULTS: One hundred and seven fetuses with cystic hygroma were included. Of the 107, cystic hygromas ameliorated in 31 fetuses (31/107: 29%). Of the 31, there were 26 livebirths. Half (n = 13) of the 26 fetuses had a good outcome, whereas the remaining half (n = 13) had abnormalities. Various abnormalities were detected in their infancies. A nuchal thickness (diameter of hygroma) of ≥5 mm was significantly correlated with abnormalities (P = 0.047). CONCLUSION: Physicians should pay attention to fetuses/neonates with ameliorated cystic hygroma. Of those, special attention should be paid to fetuses/neonates with a nuchal thickness at diagnosis ≥5 mm.
  • Yoshiki Hirata, Yusuke Katsukura, Yuka Henmi, Ren Ozawa, Sayaka Shimazaki, Akira Kurosawa, Yasushi Torii, Hironori Takahashi, Hisataka Iwata, Takehito Kuwayama, Koumei Shirasuna
    The Journal of reproduction and development 67 (4) 257 - 264 2021/08 
    Advanced maternal age is a risk factor for female infertility, and placental dysfunction is considered one of the causes of pregnancy complications. We investigated the effects of advanced maternal aging on pregnancy outcomes and placental senescence. Female pregnant mice were separated into three groups: young (3 months old), middle (8-9 months old), and aged (11-13 months old). Although the body weights of young and middle dams gradually increased during pregnancy, the body weight of aged dams only increased slightly. The placental weight and resorption rate were significantly higher, and live fetal weights were reduced in a maternal age-dependent manner. Although mRNA expression of senescence regulatory factors (p16 and p21) increased in the spleen of aged dams, mRNA expression of p16 did not change and that of p21 was reduced in the placenta of aged dams. Using a cytokine array of proteins extracted from placental tissues, the expression of various types of senescence-associated secretory phenotype (SASP) factors was decreased in aged dams compared with young and middle dams. The aged maternal placenta showed reduced immune cell accumulation compared with the young placenta. Our present results suggest that models using pregnant mice older than 8 months are more suitable for verifying older human pregnancies. These findings suggest that general cellular senescence programs may not be included in the placenta and that placental functions, including SASP production and immune cell accumulation, gradually decrease in a maternal age-dependent manner, resulting in a higher rate of pregnancy complications.
  • Ayae Ozeki, Yuka Oogaki, Yuka Henmi, Tadayoshi Karasawa, Masafumi Takahashi, Hironori Takahashi, Akihide Ohkuchi, Koumei Shirasuna
    Journal of hypertension 2021/08 
    OBJECTIVES: Maternal systemic and placental inflammatory responses participate in the pathogenesis of hypertensive disorders of pregnancy including preeclampsia, a pregnancy-specific syndrome, although the role of inflammation remains unclear. The NLRP3 inflammasome has been implicated in the control of sterile inflammation involved in preeclampsia. In the present study, we hypothesized that S100A9, as major alarmin, are associated with the pathogenesis of preeclampsia and induction of a preeclampsia-like phenotype in pregnant mice. METHODS: Plasma were taken from normal pregnant women and preeclampsia patients. Human placental tissues, trophoblast cell line Sw.71 cells, and human umbilical vein endothelial cells (HUVEC) were treated with S100A9 with or without inhibitors associated with NLRP3 inflammasome. Pregnant mice were administered S100A9. RESULTS: S100A9 was elevated in plasma and released from placentas of preeclampsia patients. S100A9 activated the NLRP3 inflammasome, resulting in IL-1β secretion, by human placental tissues and trophoblasts. In addition, secretion of soluble endoglin, a main contributor to the pathogenesis of preeclampsia, is regulated via S100A9-stimulated NLRP3 inflammasome activation in the human placenta and HUVECs. S100A9 administration significantly elevated maternal blood pressure and neutrophil accumulation within the placentas of pregnant mice, and both were significantly decreased in Nlrp3-knock out pregnant mice. CONCLUSION: The results of this study demonstrated that S100A9 acts as a danger signal to activate the NLRP3 inflammasome in the placenta, associating with hypertension during pregnancy.
  • 胎盤遺残の現状報告 周産期母子医療センターへのアンケート調査から
    高橋 宏典, 田中 博明, 三浦 清徳, 菅原 準一, 大須賀 穣, 佐藤 昌司, 齋藤 滋, 池田 智明
    日本周産期・新生児医学会雑誌 (一社)日本周産期・新生児医学会 57 (Suppl.) P200 - P200 1348-964X 2021/06
  • Yoshimitsu Wada, Hironori Takahashi, Hirotada Suzuki, Mai Ohashi, Manabu Ogoyama, Shiho Nagayama, Yosuke Baba, Rie Usui, Tatsuya Suzuki, Akihide Ohkuchi, Hiroyuki Fujiwara
    European journal of obstetrics, gynecology, and reproductive biology 260 1 - 5 2021/05 
    OBJECTIVE: To clarify the natural history of retained products of conception (RPOC) following abortion at less than 22 weeks of gestation, and those who show major bleeding during course observation. STUDY DESIGN: We retrospectively reviewed 640 patients who had spontaneous or artificial abortion at less than 22 weeks of gestation between January 2011 and August 2019 in our institute. Of those, patients with RPOC were included. The maternal background, RPOC characteristics, and subsequent complications including additional interventions were reviewed. RESULTS: Fifty-four patients with RPOC were included. The incidence of RPOC was 6.7 %. The median (interquartile range: IQR) RPOC length was 29 (20-38) mm. RPOC hypervascularity was observed in 26 (48 %) patients. The median (IQR) periods of RPOC flow disappearance and RPOC disappearance on ultrasound from abortive treatment were 50 (28-76) and 84 (50-111) days, respectively. Of the 54, 44 patients were selected for expectant management. Of the 44, 34 (77 %) patients were observed without intervention (recovery group); the other 10 (23 %) patients required additional interventions associated with subsequent bleeding (intervention group). Compared with the recovery group, heavy bleeding (> 500 mL) at abortion (6/10: 60 %) and RPOC hypervascularity (8/10: 80 %) were more frequently observed in the intervention group. CONCLUSION: Expectant management was successful in almost 80 % of patients with RPOC following abortion. The additional interventions were required in patients with heavy bleeding at abortion and RPOC hypervascularity.
  • Shigeki Matsubara, Teppei Matsubara, Hironori Takahashi
    The Australian & New Zealand journal of obstetrics & gynaecology 61 (2) E19-E20  2021/04
  • Shigeki Matsubara, Hironori Takahashi
    The journal of maternal-fetal & neonatal medicine : the official journal of the European Association of Perinatal Medicine, the Federation of Asia and Oceania Perinatal Societies, the International Society of Perinatal Obstetricians 1 - 2 2021/03
  • Yoshimitsu Wada, Hirotada Suzuki, Teppei Matsubara, Hironori Takahashi, Hiroyuki Fujiwara, Shigeki Matsubara
    The Tohoku journal of experimental medicine 253 (3) 199 - 202 2021/03 
    Subarachnoid hemorrhage is typically present in cerebral aneurysm rupture, whereas acute subdural hematoma without subarachnoid hemorrhage is rare. We herein report a case of cerebral aneurysm rupture during pregnancy resulting in acute subdural hematoma without subarachnoid hemorrhage. A 37-year-old gravida 4 para 3 pregnant woman was admitted for threatened preterm labor at 294/7 weeks of gestation. At 296/7 weeks of gestation (day -14), she developed mild left eye pain, which disappeared within one day. At 316/7 weeks of gestation (day 0), she developed the sudden onset of severe headache and nausea. A neurological examination revealed no abnormal findings, and analgesics ameliorated her headache. At 321/7 weeks of gestation (day 2), after consultations with neurosurgeons, magnetic resonance imaging showed acute subdural hematoma without subarachnoid hemorrhage. Further examinations revealed a cerebral aneurysm. Emergent clipping surgery was performed with the fetus in utero in consideration of the immaturity of the fetus and stable maternal/fetal general conditions. At 356/7 weeks of gestation (day 28), her headache of unknown cause recurred. Considering the maturity of the fetus, the patient underwent cesarean section with good maternal and neonatal outcomes. The absence of subarachnoid hemorrhage does not eliminate cerebral aneurysm rupture.
  • Manabu Ogoyama, Akihide Ohkuchi, Hironori Takahashi, Dongwei Zhao, Shigeki Matsubara, Toshihiro Takizawa
    International journal of molecular sciences 22 (3) 2021/01 
    The invasion of extravillous trophoblast (EVT) cells into the maternal decidua, which plays a crucial role in the establishment of a successful pregnancy, is highly orchestrated by a complex array of regulatory mechanisms. Non-coding RNAs (ncRNAs) that fine-tune gene expression at epigenetic, transcriptional, and post-transcriptional levels are involved in the regulatory mechanisms of EVT cell invasion. However, little is known about the characteristic features of EVT-associated ncRNAs. To elucidate the gene expression profiles of both coding and non-coding transcripts (i.e., mRNAs, long non-coding RNAs (lncRNAs), and microRNAs (miRNAs)) expressed in EVT cells, we performed RNA sequencing analysis of EVT cells isolated from first-trimester placentae. RNA sequencing analysis demonstrated that the lncRNA H19 and its derived miRNA miR-675-5p were enriched in EVT cells. Although miR-675-5p acts as a placental/trophoblast growth suppressor, there is little information on the involvement of miR-675-5p in trophoblast cell invasion. Next, we evaluated a possible role of miR-675-5p in EVT cell invasion using the EVT cell lines HTR-8/SVneo and HChEpC1b; overexpression of miR-675-5p significantly promoted the invasion of both EVT cell lines. The transcription factor gene GATA2 was shown to be a target of miR-675-5p; moreover, small interfering RNA-mediated GATA2 knockdown significantly promoted cell invasion. Furthermore, we identified MMP13 and MMP14 as downstream effectors of miR-675-5p/GATA2-dependent EVT cell invasion. These findings suggest that miR-675-5p-mediated GATA2 inhibition accelerates EVT cell invasion by upregulating matrix metalloproteinases.
  • Shigeki Matsubara, Hironori Takahashi, Yuji Takei, Hiroyasu Nakamura, Takashi Yagisawa
    Archives of gynecology and obstetrics 302 (6) 1553 - 1554 0932-0067 2020/12 [Refereed][Not invited]
  • Shigeki Matsubara, Hironori Takahashi
    Cureus 12 (11) e11492  2020/11 
    Uterine compression suture and intrauterine hemostatic balloon are important procedures to achieve hemostasis for obstetric hemorrhage. A combined use of these two, with B-Lynch suture + Bakri balloon being the most often employed ones, is referred to as a "uterine sandwich", which is an effective hemostatic procedure. Fundamentally, the former and latter stop bleeding from the uterine body and lower uterine segment, respectively. This represents the concept of "role sharing" for hemostasis. Recognizing this concept is of practical importance.
  • Hironori Takahashi, Teppei Matsubara, Shigeki Matsubara
    WOMEN AND BIRTH 33 (6) E574 - E575 1871-5192 2020/11 [Refereed][Not invited]
  • Michiya Sano, Sayaka Shimazaki, Yasuaki Kaneko, Tadayoshi Karasawa, Masafumi Takahashi, Akihide Ohkuchi, Hironori Takahashi, Akira Kurosawa, Yasushi Torii, Hisataka Iwata, Takehito Kuwayama, Koumei Shirasuna
    The Journal of reproduction and development 66 (3) 241 - 248 2020/06 [Refereed][Not invited]
     
    Maternal obesity is one of the major risk factors for pregnancy complications and is associated with low-grade chronic systemic inflammation due to higher levels of pro-inflammatory cytokines such as interleukin (IL)-1β. Pregnant women with obesity have abnormal lipid profiles, characterized by higher levels of free fatty acids, especially palmitic acid (PA). Previously, we reported that PA stimulated IL-1β secretion via activation of NLRP3 inflammasome in human placental cells. These observations led us to hypothesize that higher levels of PA induce NLRP3 inflammasome activation and placental inflammation, resulting in pregnancy complications. However, the effects of PA on NLRP3 inflammasome during pregnancy in vivo remain unclear. Therefore, PA solutions were administered intravenously into pregnant mice on day 12 of gestation. Maternal body weight was significantly decreased and absorption rates were significantly higher in PA-injected mice. The administration of PA significantly increased IL-1β protein and the mRNA expression of NLRP3 inflammasome components (NLRP3, ASC, and caspase-1) within the placenta. In murine placental cell culture, PA significantly stimulated IL-1β secretion, and this secretion was suppressed by a specific NLRP3 inhibitor (MCC950). Simultaneously, the number of macrophages/monocytes and neutrophils, together with the mRNA expression of these chemokines increased significantly in the placentas of PA-treated mice. Treatment with PA induced ASC assembling and IL-1β secretion in macrophages, and this PA-induced IL-1β secretion was significantly suppressed in NLRP3-knockdown macrophages. These results indicate that transient higher levels of PA exposure in pregnant mice activates NLRP3 inflammasome and induces placental inflammation, resulting in the incidence of absorption.
  • Hiroyuki Morisawa, Chikako Hirashima, Miho Sano, Shiho Nagayama, Hironori Takahashi, Koumei Shirasuna, Akihide Ohkuchi
    CEN case reports 9 (2) 101 - 105 2020/05 [Refereed][Not invited]
     
    There are few case reports in which circulating levels of soluble fms-like tyrosine kinase 1 (sFlt-1), placental growth factor (PlGF), and soluble endoglin (sEng) were measured before the onset of super-imposed preeclampsia in women with hemodialysis. A 40-year-old Japanese nulliparous women with hemodialysis due to diabetic nephropathy became pregnant by frozen embryo transfer. Intensive hemodialysis was started at 5 weeks of gestation. Her blood pressure (BP) in the first trimester was around 130/80 mmHg. At 20+3 weeks, she was admitted for close monitoring; her BP was 137/75 mmHg. Her BP increased to 157/88 mmHg at 31+2 weeks, and nifedipine at 20 mg/day was started at 31+6 weeks. However, the serial longitudinal measurements of sFlt-1, PlGF, and sEng did not predict the onset of super-imposed preeclampsia. Cesarean section was performed at 33+6 weeks due to uncontrollable hypertension. A healthy female infant weighing 2138 g was delivered. As for the changes of biomarkers between just before and just after hemodialysis, sFlt-1 was significantly higher just after compared with just before hemodialysis (5774 ± 1875 pg/mL vs. 2960 ± 905 pg/mL, respectively, p < 0.001). PlGF was also significantly higher just after compared with just before hemodialysis (2227 ± 1038 pg/mL vs. 1377 ± 614 pg/mL, respectively, p < 0.001). However, the sFlt-1/PlGF ratio and sEng levels were not significantly different between just before and just after hemodialysis (p = 0.115, p = 0.672, respectively). In conclusion, prediction of early-onset super-imposed preeclampsia using angiogenic and anti-angiogenic markers in pregnant women with hemodialysis might be difficult.
  • Shigeki Matsubara, Hironori Takahashi, Yuji Takei, Yasushi Imai
    Journal of clinical pharmacy and therapeutics 45 (2) 399 - 400 2020/04 [Refereed][Not invited]
  • Manabu Ogoyama, Hiroyasu Nakamura, Atsushi Ugajin, Shiho Nagayama, Hirotada Suzuki, Hironori Takahashi, Yosuke Baba, Rie Usui, Shigeki Matsubara, Akihide Ohkuchi
    The journal of obstetrics and gynaecology research 46 (2) 249 - 255 1341-8076 2020/02 [Refereed][Not invited]
     
    AIM: We examined whether critical conditions, which were defined as having hemoglobin (Hb) less than 7.0 g/dL, shock index ≥1.0, or need for transfusion, were associated with the presence of extravasation (EV) on dynamic computed tomography (CT) in women with late post-partum hemorrhage (PPH). METHODS: Forty post-partum women with late PPH without evident retained products of conception performed dynamic CT. Two radiologists retrospectively evaluated dynamic CT, and determined the presence or absence of EV and a sac-like structure within the uterine cavity with enhancement. RESULTS: Ultrasound images were available in 34/40 patients. Color Doppler flow in uterine cavity was evaluated in 33/34 (97%), and all women showed abnormal flow. Of 40 patients, dynamic CT revealed EV in 8 (20%), and a sac-like structure in 30 (75%). Thus, we diagnosed these 38 (95%) as having uterine artery pseudoaneurysm (UAP). Uterine artery embolization was performed in 36/38 diagnosed as having UAP, and in 2/2 patients with an unknown cause of hemorrhage. The incidence rates of critical conditions were significantly increased in PPH women with than without EV on dynamic CT: Hb <7.0 g/dL (62.5 vs 0%, [P < 0.001]), shock index ≥1.0 (50 vs 9.4% [P = 0.020]), and need for transfusion (37.5 vs 0% [P = 0.006]). Abnormal color Doppler flows were observed in all patients with either EV and sac on dynamic CT. CONCLUSION: Dynamic CT was useful for diagnosing UAP, and for evaluating critical conditions, in women with late PPH not complicated by retained products of conception.
  • Shigeki Matsubara, Hironori Takahashi
    European journal of obstetrics, gynecology, and reproductive biology 244 198 - 199 0301-2115 2020/01 [Refereed][Not invited]
  • Shiho Nagayama, Hironori Takahashi, Shohei Tozawa, Risa Narumi, Rie Usui, Akihide Ohkuchi, Shigeki Matsubara
    Case reports in obstetrics and gynecology 2020 9408501 - 9408501 2020 [Refereed][Not invited]
     
    An interstitial pregnancy that continues beyond the second trimester is a rare phenomenon. We report a patient with an interstitial pregnancy undiagnosed until the third trimester. A multiparous woman was referred to us because of preeclampsia at 26 weeks of gestation. The placental position was the right fundus, and color Doppler ultrasound revealed myometrial thinning and subplacental hypervascularity, leading to a suspicion of placenta accreta spectrum (PAS). Emergency cesarean section was performed at 281/7 weeks of gestation due to severe preeclampsia. The right tubal horn to the isthmus of the fallopian tube bulged with placental adhesion and a part of the tube had ruptured, with the omentum adhering to the ruptured part. Interstitial and tubal isthmic pregnancy with uterine rupture was diagnosed.
  • Hironori Takahashi, Manabu Ogoyama, Shiho Nagayama, Hirotada Suzuki, Akihide Ohkuchi, Shigeki Matsubara, Toshihiro Takizawa
    The journal of maternal-fetal & neonatal medicine : the official journal of the European Association of Perinatal Medicine, the Federation of Asia and Oceania Perinatal Societies, the International Society of Perinatal Obstetricians 1 - 9 1476-7058 2019/11 [Refereed][Not invited]
     
    Introduction: Appropriate extravillous trophoblast (EVT) invasion is essential for successful pregnancy. Previously, we showed that EVTs express CD44, which accelerated EVT invasion. However, its regulation mechanism via CD44 remains unknown. Our hypothesis was that WNT signaling enhanced EVT invasion via CD44. To test this hypothesis, we investigated the effects of WNT ligands on CD44 expression and EVT invasion using EVT cell lines and isolated primary EVTs.Methods: We used EVT cell lines (HTR8/SVneo and HChEpC1b) and isolated primary EVTs, extracted from first-trimester trophoblasts. The cells were supplemented with WNT3A, 5A, and 10B. We examined cell invasion and the expressions of CD44 and matrix metalloproteinase (MMP) 9. Next, to clarify the pathway of WNT10B in EVTs, we knock-downed WNT10B using siRNA and activated or inhibited the WNT canonical pathway using an activator (lithium chloride) or inhibitor (FH535, XAV939) with WNT10B addition.Results: WNT3A, 5A, and 10B accelerated the invasion in the EVT lines and isolated primary EVTs. The expressions of CD44 and MMP9 were also upregulated by WNT ligands. WNT10B knockdown significantly inhibited EVT invasion concomitantly with CD44 expression. The WNT canonical pathway activator upregulated CD44 expression and its inhibitor downregulated it with WNT10B addition.Conclusions: The present study is the first to show the possibility that WNT3A, WNT5A, and WNT10B exist upstream of CD44 in EVTs. Among them, WNT10B may be a novel accelerator of EVT invasion. WNT signaling mediated by multiple WNT ligands may contribute to EVT invasion.
  • Matsubara S, Takahashi H, Horie H, Kawada M
    Acta obstetricia et gynecologica Scandinavica 0001-6349 2019/09 [Refereed][Not invited]
  • Hironori Takahashi, Mai Ohhashi, Yosuke Baba, Shiho Nagayama, Manabu Ogoyama, Kenji Horie, Hirotada Suzuki, Rie Usui, Akihide Ohkuchi, Shigeki Matsubara
    EUROPEAN JOURNAL OF OBSTETRICS & GYNECOLOGY AND REPRODUCTIVE BIOLOGY 240 87 - 92 0301-2115 2019/09 [Refereed][Not invited]
     
    Objectives: To clarify the outcome of retained products of conception (RPOC) without placenta previa.Study design: This was a retrospective cohort study consisting of 59 patients who abdominally or vaginally gave birth to infants after 14 weeks without placenta previa and had RPOC between April 2006 and December 2018. Patients' background, characteristics, and outcomes were compared between those requiring and not-requiring intervention for RPOC.Results: Of the 59 patients, pregnancies after assisted reproductive technology accounted for 18 (31%). The ultrasound-measured RPOC length was 4 cm (median) and 39 (66%) showed hypervascularity within RPOC. Interventions were required in 36 patients (61%), with all due to bleeding-related events. Multivariate regression analyses revealed that the interventions were significantly more likely in the following situations: younger than 35 years (aOR: 4.2, 95%CI: 1.1-18.5), RPOC length >= 4 cm (aOR: 8.6, 95% CI: 2.4-39.2), and RPOC hypervascularity (aOR: 4.6, 95%CI: 1.3-18.8). Methotrexate was administered to 8 patients, of whom 4 (50%) required further hemostatic interventions.Conclusion: In patients with RPOC without previa, 61 and 39% did and did not require hemostatic interventions, respectively. In the latter, a wait-and-see strategy resulted in the resolution of RPOC. Patients with larger RPOC (>= 4-cm fragment length) and hypervascularity were significantly more likely to require hemostatic intervention. (C) 2019 Elsevier B.V. All rights reserved.
  • Ganesh Acharya, Marisa Bartolomei, Anthony M Carter, Larry Chamley, Charles F Cotton, Junichi Hasegawa, Yuri Hasegawa, Satoshi Hayakawa, Mari Kawaguchi, Chaini Konwar, Shoichi Magawa, Kiyonori Miura, Hirotaka Nishi, Carlos Salomon, Keiichi Sato, Hidenobu Soejima, Hiroaki Soma, Anne Sørensen, Hironori Takahashi, Taketeru Tomita, Camilla M Whittington, Victor Yuan, Perrie O'Tierney-Ginn
    Placenta 84 4 - 8 0143-4004 2019/09 [Refereed][Not invited]
     
    Workshops are an important part of the IFPA annual meeting as they allow for discussion of specialized topics. At IFPA meeting 2018 there were nine themed workshops, four of which are summarized in this report. These workshops discussed new knowledge and technological innovations in the following areas of research: 1) viviparity in ocean-living species; 2) placental imaging; 3) epigenetics; and 4) extracellular vesicles in pregnancy.
  • Ohkuchi A, Hirashima C, Arai R, Takahashi K, Suzuki H, Ogoyama M, Nagayama S, Takahashi H, Baba Y, Usui R, Shirasuna K, Matsubara S
    Hypertension research : official journal of the Japanese Society of Hypertension 0916-9636 2019/08 [Refereed][Not invited]
  • Ozeki A, Tani K, Takahashi H, Suzuki H, Nagayama S, Hirashima C, Iwata H, Kuwayama T, Ohkuchi A, Shirasuna K
    Journal of hypertension 0263-6352 2019/08 [Refereed][Not invited]
  • Hironori Takahashi, Teppei Matsubara, Kenji Horie, Ami Kobayashi, Rieko Furukawa, Shigeki Matsubara
    JOURNAL OF OBSTETRICS AND GYNAECOLOGY RESEARCH 45 (8) 1619 - 1625 1341-8076 2019/08 [Refereed][Not invited]
     
    Fetal seizure is rarely observed. Investigation of both video-recording of seizures and cardiotocography is crucial for a precise diagnosis. Here, we report a case of fetal seizure, and also show a video-ultrasound recording. A 40-year-old woman was admitted to us due to loss of variability in cardiotocography. Ultrasound repeatedly revealed opisthotonus-like and clonic-seizure-like movements. After the abnormal movement, tachycardia up to 210 bpm (postictal tachycardia) was noted. Ultrasound revealed a nuchal cord. A careful investigation of video-ultrasound recording by an epilepsy specialist led to the confirmation of epileptic seizures. At 36(4/7), she vaginally gave birth to an infant with an umbilical artery pH of 7.22. The infant died 30 min after birth. No clear video-recordings associated with fetal seizure were available for cases reported so far in the literature. The video provided in this case may be of use for further analyses.
  • Matsubara S, Takahashi H
    The journal of maternal-fetal & neonatal medicine : the official journal of the European Association of Perinatal Medicine, the Federation of Asia and Oceania Perinatal Societies, the International Society of Perinatal Obstetricians 1 - 2 1476-7058 2019/07 [Refereed][Not invited]
  • Matsubara S, Igarashi T, Takahashi H
    Acta obstetricia et gynecologica Scandinavica 98 (10) 1357  0001-6349 2019/06 [Refereed][Not invited]
  • Matsubara S, Takahashi H, Lefor AK
    The journal of obstetrics and gynaecology research 45 (9) 1961 - 1962 1341-8076 2019/06 [Refereed][Not invited]
  • Matsubara S, Takahashi H
    Placenta 85 78 - 79 0143-4004 2019/06 [Refereed][Not invited]
  • Nagamori T, Takahashi H, Yoshida Y, Oka H, Yamamoto S, Manabe H, Taketazu G, Mukai T, Sakata H, Oki J, Azuma H
    Journal of paediatrics and child health 55 (5) 609 - 610 1034-4810 2019/05 [Refereed][Not invited]
  • Matsubara S, Takahashi H
    Taiwanese journal of obstetrics & gynecology 58 (3) 438 - 439 1028-4559 2019/05 [Refereed][Not invited]
  • Matsubara D, Takahashi H, Matsubara S
    Archives of gynecology and obstetrics 300 (1) 235 - 236 0932-0067 2019/05 [Refereed][Not invited]
  • Matsubara S, Takahashi H, Lefor AK
    The journal of obstetrics and gynaecology research 45 (7) 1429 - 1430 1341-8076 2019/05 [Refereed][Not invited]
  • Matsubara S, Takahashi H, Yano H
    International journal of gynaecology and obstetrics: the official organ of the International Federation of Gynaecology and Obstetrics 145 (2) 244  0020-7292 2019/05 [Refereed][Not invited]
  • Kaneko Y, Sano M, Seno K, Oogaki Y, Takahashi H, Ohkuchi A, Yokozawa M, Yamauchi K, Iwata H, Kuwayama T, Shirasuna K
    Nutrients 11 (5) 2019/04 [Refereed][Not invited]
  • Takahashi H, Matsubara S
    The journal of maternal-fetal & neonatal medicine : the official journal of the European Association of Perinatal Medicine, the Federation of Asia and Oceania Perinatal Societies, the International Society of Perinatal Obstetricians 1 - 71 1476-7058 2019/04 [Refereed][Not invited]
  • Matsubara S, Takahashi H, Takei Y
    Archives of gynecology and obstetrics 0932-0067 2019/03 [Refereed][Not invited]
  • Matsubara S, Takahashi H
    Journal of obstetrics and gynaecology : the journal of the Institute of Obstetrics and Gynaecology 1  0144-3615 2019/03 [Refereed][Not invited]
  • Sugiyama M, Takahashi H, Baba Y, Taneichi A, Suzuki H, Usui R, Takei Y, Ohkuchi A, Fujiwara H, Matsubara S
    The journal of maternal-fetal & neonatal medicine : the official journal of the European Association of Perinatal Medicine, the Federation of Asia and Oceania Perinatal Societies, the International Society of Perinatal Obstetricians 1 - 5 1476-7058 2019/03 [Refereed][Not invited]
  • Matsubara S, Takahashi H, Lefor AK
    The journal of obstetrics and gynaecology research 45 (5) 1085 - 1086 1341-8076 2019/02 [Refereed][Not invited]
  • Fujimoto Y, Takahashi H, Horie K, Nakaya T, Niki T, Fujiwara H, Matsubara S
    Case reports in obstetrics and gynecology 2019 3120921  2090-6684 2019 [Refereed][Not invited]
  • Matsubara S, Takahashi H, Takei Y, Lefor AK, Fujiwara H
    Acta obstetricia et gynecologica Scandinavica 0001-6349 2019/01 [Refereed][Not invited]
  • Horie K, Takahashi H, Fujimoto Y, Kaneko D, Yada Y, Matsubara S
    The journal of obstetrics and gynaecology research 45 (5) 1071 - 1075 1341-8076 2019/01 [Refereed][Not invited]
  • Takahashi H, Baba Y, Usui R, Suzuki H, Ohkuchi A, Matsubara S
    The journal of maternal-fetal & neonatal medicine : the official journal of the European Association of Perinatal Medicine, the Federation of Asia and Oceania Perinatal Societies, the International Society of Perinatal Obstetricians 1 - 161 1476-7058 2018/12 [Refereed][Not invited]
  • Matsubara S, Takahashi S, Takahashi H
    Archives of gynecology and obstetrics 299 (2) 593 - 594 0932-0067 2018/12 [Refereed][Not invited]
  • Matsubara S, Takahashi H
    Journal of obstetrics and gynaecology : the journal of the Institute of Obstetrics and Gynaecology 39 (4) 1  0144-3615 2018/12 [Refereed][Not invited]
  • Sano Michiya, Seno Kotomi, Munakata Yasuhisa, Kawahara-Miki Ryouka, Takahashi Hironori, Iwata Hisataka, Kuwayama Takehito, Ohkuchi Akihide, Shirasuna Koumei
    JOURNAL OF REPRODUCTIVE IMMUNOLOGY 130 41  0165-0378 2018/11 [Refereed][Not invited]
  • Takahashi Hironori, Ogoyama Manabu, Nagayama Shiho, Ohkuchi Akihide, Takizawa Toshihiro, Matsubara Shigeki
    JOURNAL OF REPRODUCTIVE IMMUNOLOGY 130 41  0165-0378 2018/11 [Refereed][Not invited]
  • Ozeki Ayae, Sase Saoko, Hosoda Momoko, Takahashi Hironori, Suzuki Hirotada, Nagayama Shiho, Hirashima Chikako, Iwata Hisataka, Kuwayama Takehito, Ohkuchi Akihide, Shirasuna Koumei
    JOURNAL OF REPRODUCTIVE IMMUNOLOGY 130 31 - 32 0165-0378 2018/11 [Refereed][Not invited]
  • Hironori Takahashi, Yosuke Baba, Rie Usui, Akihide Ohkuchi, Shigeki Matsubara
    HYPERTENSION RESEARCH IN PREGNANCY 6 (2) 73 - 75 2187-5987 2018/11 [Refereed][Not invited]
  • Matsubara D, Kataoka K, Takahashi H, Minami T, Yamagata T
    International heart journal 60 (1) 100 - 107 1349-2365 2018/11 [Refereed][Not invited]
  • Otake Y, Kanazawa H, Takahashi H, Matsubara S, Sugimoto H
    European Journal of Obstetrics & Gynecology and Reproductive Biology 232 82 - 86 0301-2115 2018/11 [Refereed][Not invited]
  • Hironori Takahashi, Daisuke Matsubara, Shigeki Matsubara
    AUSTRALIAN & NEW ZEALAND JOURNAL OF OBSTETRICS & GYNAECOLOGY 58 (5) E14 - E15 0004-8666 2018/10 [Refereed][Not invited]
  • Hironori Takahashi, Daisuke Matsubara, Shigeki Matsubara
    AUSTRALIAN & NEW ZEALAND JOURNAL OF OBSTETRICS & GYNAECOLOGY 58 (5) E14 - E15 0004-8666 2018/10 [Refereed][Not invited]
  • Chikako Hirashima, Takako Ohmaru-Nakanishi, Shiho Nagayama, Kayo Takahashi, Hirotada Suzuki, Hironori Takahashi, Rie Usui, Koumei Shirasuna, Shigeki Matsubara, Akihide Ohkuchi
    Pregnancy Hypertension Elsevier {BV} 14 174 - 176 2210-7789 2018/10 [Refereed][Not invited]
  • Takahashi H, Baba Y, Usui R, Suzuki H, Horie K, Yano H, Ohkuchi A, Matsubara S
    Archives of gynecology and obstetrics 299 (1) 113 - 121 0932-0067 2018/10 [Refereed][Not invited]
  • Toshihiro Takizawa, Chaw Kyi-Tha-Thu, Hironori Takahashi, Manabu Ogoyama, Akihide Ohkuchi, Toshiyuki Takeshita, Shigeki Matsubara
    PLACENTA 69 E90 - E90 0143-4004 2018/09 [Refereed][Not invited]
  • Shirasuna Koumei, Ozeki Ayae, Takahashi Hironori, Ohkuchi Akihide, Iwata Hisataka, Kuwayama Takehito
    PLACENTA 69 E82  0143-4004 2018/09 [Refereed][Not invited]
  • Matsubara S, Takahashi H, Suzuki T
    Archives of gynecology and obstetrics 298 (3) 459 - 460 0932-0067 2018/09 [Refereed][Not invited]
  • Seno K, Munakata Y, Sano M, Kawahara-Miki R, Takahashi H, Ohkuchi A, Iwata H, Kuwayama T, Shirasuna K
    International journal of molecular sciences 19 (8) 2018/08 [Refereed][Not invited]
  • Takahashi H, Matsubara S
    Acta obstetricia et gynecologica Scandinavica 98 (2) 264 - 265 0001-6349 2018/08 [Refereed][Not invited]
  • Suzuki H, Nagayama S, Hirashima C, Takahashi K, Takahashi H, Ogoyama M, Nagayama M, Shirasuna K, Matsubara S, Ohkuchi A
    The journal of obstetrics and gynaecology research 45 (1) 96 - 103 1341-8076 2018/08 [Refereed][Not invited]
  • Matsubara S, Takahashi H, Usui R
    The journal of obstetrics and gynaecology research 44 (8) 1499 - 1500 1341-8076 2018/08 [Refereed][Not invited]
  • Matsubara S, Takahashi H, Yano H
    The journal of obstetrics and gynaecology research 44 (10) 2016 - 2017 1341-8076 2018/07 [Refereed][Not invited]
  • Matsubara S, Takahashi H, Ohkuchi A
    American journal of obstetrics and gynecology Elsevier {BV} 219 (5) 515 - 516 0002-9378 2018/07 [Refereed][Not invited]
  • Shigeki Matsubara, Hironori Takahashi
    Archives of Gynecology and Obstetrics 298 (2) 1 - 2 1432-0711 2018/06 [Refereed][Not invited]
  • Shigeki Matsubara, Hironori Takahashi
    Chinese Medical Journal 131 (12) 1504 - 1505 0366-6999 2018/06 [Refereed][Not invited]
  • Shigeki Matsubara, Hironori Takahashi
    Archives of Gynecology and Obstetrics 298 (2) 1 - 2 1432-0711 2018/06 [Refereed][Not invited]
  • Horie K, Takahashi H, Matsubara D, Kataoka K, Furukawa R, Baba Y, Ohkuchi A, Matsubara S
    Case reports in obstetrics and gynecology 2018 6591025  2090-6684 2018/06 [Refereed][Not invited]
  • Okada N, Sasaki A, Saito J, Mitani Y, Yachie A, Takahashi H, Matsubara S, Tenkumo C, Tanaka H, Hata T, Motomura K, Nagasawa J, Wada Y, Sako M, Yamaguchi K, Matsumoto K, Nakamura H, Sago H, Mizuta K
    The journal of maternal-fetal & neonatal medicine : the official journal of the European Association of Perinatal Medicine, the Federation of Asia and Oceania Perinatal Societies, the International Society of Perinatal Obstetricians 1 - 131 1476-7058 2018/06 [Refereed][Not invited]
  • Matsubara S, Takahashi H
    Journal of obstetrics and gynaecology : the journal of the Institute of Obstetrics and Gynaecology 38 (8) 1  0144-3615 2018/06 [Refereed][Not invited]
  • Shigeki Matsubara, Hironori Takahashi, Daisuke Matsubara, Akihide Ohkuchi
    BJOG: An International Journal of Obstetrics and Gynaecology 125 (7) 905 - 906 1471-0528 2018/06 [Refereed][Not invited]
  • Kotomi Seno, Nao Tanikawa, Hironori Takahashi, Akihide Ohkuchi, Hirotada Suzuki, Shigeki Matsubara, Hisataka Iwata, Takehito Kuwayama, Koumei Shirasuna
    American Journal of Reproductive Immunology 79 (6) e12826  1600-0897 2018/06 [Refereed][Not invited]
     
    Problem: We investigated the effect of oxygen concentrations on cellular senescence and autophagy and examined the role of autophagy in human trophoblast cells. Method of study: Human first-trimester trophoblast cells (Sw.71) were incubated under 21%, 5%, or 1% O2 concentrations for 24 hours. We examined the extent of senescence caused using senescence-associated β-galactosidase (SA-β-Gal) and senescence-associated secretory phenotype (SASP) as markers. Moreover, we examined the role of autophagy in causing cellular senescence using an autophagy inhibitor (3-methyladenine, 3MA). Results: Physiological normoxia (5% O2) decreased SA-β-Gal-positive cells and SASP including interleukin-6 (IL-6) and IL-8 compared with cultured cells in 21% O2. Pathophysiological hypoxia (1% O2) caused cytotoxicity, including extracellular release of ATP and lactate dehydrogenase, and decreased senescence phenotypes. 3MA-treated trophoblast cells significantly suppressed senescence markers (SA-β-Gal-positive cells and SASP secretion) in O2-independent manner. Conclusion: We conclude that O2 concentration modulates cellular senescence phenotypes regulating autophagy in the human trophoblast cells. Moreover, inhibiting autophagy suppresses cellular senescence, suggesting that autophagy contributes to oxygen stress-induced cellular senescence.
  • Shigeki Matsubara, Hironori Takahashi, Yosuke Baba
    Journal of Obstetrics and Gynaecology Research 44 (6) 1186 - 1187 1447-0756 2018/06 [Refereed][Not invited]
  • Shigeki Matsubara, Yosuke Baba, Hironori Takahashi
    Journal of Maternal-Fetal and Neonatal Medicine 31 (10) 1390 - 1391 1476-4954 2018/05 [Refereed][Not invited]
  • Matsubara S, Takahashi H
    The journal of maternal-fetal & neonatal medicine : the official journal of the European Association of Perinatal Medicine, the Federation of Asia and Oceania Perinatal Societies, the International Society of Perinatal Obstetricians 1 - 2 1476-7058 2018/05 [Refereed][Not invited]
  • Matsubara S, Takahashi H, Takei Y
    American journal of obstetrics and gynecology Elsevier {BV} 219 (3) 312  0002-9378 2018/05 [Refereed][Not invited]
  • Shigeki Matsubara, Hironori Takahashi, Akihide Ohkuchi, Hideki Kumagai, Shizukiyo Ishikawa
    Pediatric Allergy and Immunology 29 (3) 332 - 333 1399-3038 2018/05 [Refereed][Not invited]
  • Hironori Takahashi, Akihide Ohkuchi, Rie Usui, Hirotada Suzuki, Yosuke Baba, Shigeki Matsubara
    International Journal of Gynecology and Obstetrics 140 (3) 357 - 364 1879-3479 2018/03 [Refereed][Not invited]
     
    Objective: To determine the efficacy and safety of the Matsubara–Takahashi cervix-holding technique (MT-holding) for achieving hemostasis for postpartum hemorrhage (PPH). Methods: The present retrospective observational study included data from deliveries that occurred between January 1, 2004, and December 31, 2014, at the Department of Obstetrics and Gynecology, Jichi Medical University, Shimotsuke, Japan. Deliveries were included where patients experienced blood loss greater than 2500 mL and MT-holding was used. The success rates of the technique in patients with placenta accreta spectrum (PAS) disorders and PPH were determined subsequent pregnancy outcomes were also examined. Results: There were 53 deliveries included in the study 29 patients had placenta previa and 8 of these patients also had PAS disorders. MT-holding achieved hemostasis in 15 (71%) and 4 (50%) patients with placenta previa without and with PAS disorders, respectively the placenta was removed in the latter. Overall, MT-holding achieved hemostasis in 40 (75%) deliveries. Of nine patients who became pregnant after this procedure, six went on to have full-term deliveries. Conclusion: MT-holding achieved hemostasis in 50% of patients with PAS disorders and had an overall success rate of 75% for PPH, comparable to other uterus-sparing procedures. MT-holding is suggested as a simple, effective, safe technique available to less-experienced obstetrician these findings require confirmation in larger studies.
  • Shigeki Matsubara, Daisuke Matsubara, Hironori Takahashi, Yosuke Baba
    Journal of Maternal-Fetal and Neonatal Medicine 31 (2) 251 - 252 1476-4954 2018/01 [Refereed][Not invited]
  • Shigeki Matsubara, Hironori Takahashi, Rie Usui
    Journal of Obstetrics and Gynaecology 38 (1) 146 - 147 1364-6893 2018/01 [Refereed][Not invited]
  • S. Matsubara, H. Takahashi
    Clinical and Experimental Obstetrics and Gynecology 45 (1) 72 - 74 0390-6663 2018 [Refereed][Not invited]
     
    Uterine artery pseudoaneurysm (UAP), an important cause of postabortal or postpartum hemorrhage, usually accompanies a preceding event, which injures the arterial wall, leading to pseudoaneurysm formation. The authors here propose a new concept, UAP without preceding events. Simultaneous occurrence of UAP and cesarean scar pregnancy may well illustrate the situation.
  • Baba Y, Takahashi H, Morisawa H, Matsubara D, Tamura K, Usui R, Matsubara S
    Case Reports in Obstetrics and Gynecology 2018 2158248  2090-6684 2018 [Refereed][Not invited]
  • Shigeki Matsubara, Hironori Takahashi, Tatsuya Suzuki
    Archives of Gynecology and Obstetrics 297 (1) 269 - 270 1432-0711 2018/01 [Refereed][Not invited]
  • Shigeki Matsubara, Hironori Takahashi
    Archives of Gynecology and Obstetrics 297 (1) 1 - 2 1432-0711 2018/01 [Refereed][Not invited]
     
    Introduction: Intentional placental removal for abnormally invasive placenta (AIP) is fundamentally abandoned at planned surgery for it. Whether this holds true even after recent introduction of various hemostatic procedures is unclear. Materials and Methods: We discussed on this issue based on our own experiences and also on the recent reports on various hemostatic procedures. Results: Studies directly answering this question have been lacking. We must weigh the balance between the massive bleeding and possibility of uterus-preservation when intentional placental removal strategy is employed. Conclusion: An almost forgotten strategy, the “intentional placental removal” for planned AIP surgery may regain its position when appropriate hemostatic procedures are concomitantly used depending on the situation. Even employing this strategy, quick decision to perform hysterectomy under multidisciplinary team may be important.
  • Matsubara S, Takahashi H
    The journal of maternal-fetal & neonatal medicine : the official journal of the European Association of Perinatal Medicine, the Federation of Asia and Oceania Perinatal Societies, the International Society of Perinatal Obstetricians 1 - 2 1476-7058 2018/01 [Refereed][Not invited]
  • Chikako Hirashima, Akihide Ohkuchi, Shiho Nagayama, Hirotada Suzuki, Kayo Takahashi, Manabu Ogoyama, Hironori Takahashi, Koumei Shirasuna, Shigeki Matsubara
    Hypertension Research 41 (1) 45 - 52 1348-4214 2018 [Refereed][Not invited]
     
    Our aim was to evaluate whether the serum level of galectin-1 (Gal-1) at 18-24 and 27-31 weeks of gestation is a risk factor for predicting the later occurrence of not only preeclampsia (PE) but also gestational hypertension (GH). We measured serum levels of soluble fms-like tyrosine kinase 1 (sFlt-1), placental growth factor (PlGF), and Gal-1 using an enzyme-linked immunosorbent assay in 81 and 73 normal pregnant women, 22 and 16 women with a later onset of GH, and 37 and 29 women with a later onset of PE at 18-24 and 27-31 weeks, respectively. We also measured Gal-1 in 33 women with GH and 78 women with PE after the onset. The levels of Gal-1 after the onset of GH, late-onset PE (onset at ≫34 weeks), and earlyonset PE (onset at o34 weeks) were significantly higher than those in normal pregnant women at 27-31 weeks. However, the low levels of Gal-1 (o8.1 ng ml-1) at 18-24 weeks, but not at 27-31 weeks, predicted the later occurrence of not only earlyonset PE and late-onset PE but also GH. The low level of Gal-1 at 18-24 weeks was an independent risk factor for the later occurrence of GH and PE, after adjusting for the effects of a high BP and increased sFlt-1/PlGF ratio at 18-24 weeks. In conclusion, the serum level of Gal-1 is a novel risk factor for both GH and PE, specifically its expression at a low level in the second trimester and a high level after onset.
  • Shigeki Matsubara, Daisuke Matsubara, Hironori Takahashi
    JOURNAL OF OBSTETRICS AND GYNAECOLOGY RESEARCH 43 (12) 1890 - 1891 1341-8076 2017/12 [Refereed][Not invited]
  • Yoichi Ishida, Akihide Ohkuchi, Tatsuya Suzuki, Toshihiro Takizawa, Hironori Takahashi, Shigeki Matsubara
    JOURNAL OF REPRODUCTIVE IMMUNOLOGY 124 82 - 82 0165-0378 2017/11 [Refereed][Not invited]
  • Hironori Takahashi
    PLACENTA 59 179 - 180 0143-4004 2017/11 [Refereed][Not invited]
  • Toshihiro Takizawa, Hironori Takahashi, Chaw Kyi-Tha-Thu, Manabu Ogoyama, Akihide Ohkuchi, Toshiyuki Takeshita, Shigeki Matsubara
    JOURNAL OF REPRODUCTIVE IMMUNOLOGY 124 73 - 73 0165-0378 2017/11 [Refereed][Not invited]
  • Ohhashi Mai, Takahashi Hironori, Baba Yosuke, Suzuki Hirotada, Horie Kenji, Usui Rie, Ohkuchi Akihide, Watanabe Takashi, Matsubara Shigeki
    HYPERTENSION RESEARCH IN PREGNANCY 5 (2) 59 - 64 2187-5987 2017/11 [Refereed][Not invited]
  • Shigeki Matsubara, Hironori Takahashi, Yosuke Baba
    ARCHIVES OF GYNECOLOGY AND OBSTETRICS 296 (5) 851 - 853 0932-0067 2017/11 [Refereed][Not invited]
     
    Background At cesarean hysterectomy for abnormally invasive placenta, rupture of aberrant vessels around the uterus causes massive bleeding. Purpose This study aimed at describing a technique to reduce bleeding from aberrant vessels at the posterior bladder wall in this surgery. Methods The bladder is filled with 200-300 mL of water during handling the posterior bladder wall. Results This technique facilitates understanding that some aberrant vessels do not have communications with the cervix-uterus. Some aberrant vessels have communication with the cervix-uterus and this technique makes cutting and ligation of these vessels easy. Conclusions Filling the bladder may reduce bleeding from the posterior bladder wall at cesarean hysterectomy for abnormally invasive placenta.
  • Shigeki Matsubara, Hironori Takahashi
    ARCHIVES OF GYNECOLOGY AND OBSTETRICS 296 (5) 1039 - 1040 0932-0067 2017/11 [Refereed][Not invited]
  • Shigeki Matsubara, Hironori Takahashi, Yosuke Baba, Alan Kawarai Lefor
    BJOG-AN INTERNATIONAL JOURNAL OF OBSTETRICS AND GYNAECOLOGY 124 (11) 1792 - 1793 1470-0328 2017/10 [Refereed][Not invited]
  • Shigeki Matsubara, Daisuke Matsubara, Yosuke Baba, Hironori Takahashi
    JOURNAL OF OBSTETRICS AND GYNAECOLOGY 37 (7) 973 - 973 0144-3615 2017/10 [Refereed][Not invited]
  • Shigeki Matsubara, Hironori Takahashi, Yosuke Baba
    JOURNAL OF OBSTETRICS AND GYNAECOLOGY RESEARCH 43 (10) 1660 - 1661 1341-8076 2017/10 [Refereed][Not invited]
  • Matsubara S, Matsubara D, Takahashi H, Lefor AK
    BJOG : an international journal of obstetrics and gynaecology 124 (10) 1621 - 1622 1470-0328 2017/09 [Refereed][Not invited]
  • Shigeki Matsubara, Hironori Takahashi, Yosuke Baba
    JOURNAL OF ANESTHESIA 31 (4) 642 - 642 0913-8668 2017/08 [Refereed][Not invited]
  • Hironori Takahashi, Daisuke Matsubara, Shigeru Ono, Noriko Hirose, Shigeki Matsubara
    EUROPEAN JOURNAL OF OBSTETRICS & GYNECOLOGY AND REPRODUCTIVE BIOLOGY 215 259 - 260 0301-2115 2017/08 [Refereed][Not invited]
  • Shigeki Matsubara, Hironori Takahashi, Daisuke Matsubara, Yosuke Baba
    JOURNAL OF ZHEJIANG UNIVERSITY-SCIENCE B 18 (8) 723 - 724 1673-1581 2017/08 [Refereed][Not invited]
  • Shigeki Matsubara, Hironori Takahashi, Daisuke Matsubara, Akihide Ohkuchi
    ACTA OBSTETRICIA ET GYNECOLOGICA SCANDINAVICA 96 (8) 1029 - 1029 0001-6349 2017/08 [Refereed][Not invited]
  • Shigeki Matsubara, Hironori Takahashi, Alan Kawarai Lefor
    AMERICAN JOURNAL OF OBSTETRICS AND GYNECOLOGY 217 (1) 101 - 102 0002-9378 2017/07 [Refereed][Not invited]
  • Hironori Takahashi, Toshihiro Takizawa, Shigeki Matsubara
    JOURNAL OF MATERNAL-FETAL & NEONATAL MEDICINE 30 (9) 1087 - 1088 1476-7058 2017/05 [Refereed][Not invited]
  • Shigeki Matsubara, Hironori Takahashi, Daisuke Matsubara
    TAIWANESE JOURNAL OF OBSTETRICS & GYNECOLOGY 56 (2) 270 - 270 1028-4559 2017/04 [Refereed][Not invited]
  • Shigeki Matsubara, Hironori Takahashi
    JOURNAL OF OBSTETRICS AND GYNAECOLOGY 37 (3) 403 - 403 0144-3615 2017/04 [Refereed][Not invited]
  • Manabu Ogoyama, Hironori Takahashi, Rie Usui, Yosuke Baba, Hirotada Suzuki, Akihide Ohkuchi, Shigeki Matsubara
    EUROPEAN JOURNAL OF OBSTETRICS & GYNECOLOGY AND REPRODUCTIVE BIOLOGY 210 281 - 285 0301-2115 2017/03 [Refereed][Not invited]
     
    Objective: The intrauterine balloon (Balloon) has recently been widely used to achieve hemostasis for postpartum hemorrhage (PPH). We concomitantly used a novel method, "holding the cervix", with the Balloon to prevent Balloon prolapse and achieve hemostasis. We aimed to clarify the following three factors: 1) hemostatic success rate of Balloon use for PPH, 2) effect of holding the cervix on Balloon prolapse, and, 3) the rate of bleeding after Balloon insertion, possibly predictive of Balloon failure. Study design: We retrospectively examined 80 patients undergoing Balloon application for PPH in our institution. We defined "success" as achieving hemostasis with no requirement of additional invasive procedures, and "failure" as their requirement. Between success vs. failure, several parameters were compared. For statistical analyses, Fisher's exact test and Wilcoxon rank sum test were applied. Results: Excluding "unable to insert" patients, "holding the cervix" was performed in 56 (75%). Prolapse was less likely to occur in patients with than in those without "holding the cervix" (4 vs. 11%, respectively). The success rate in patients with "Balloon + holding the cervix" was 94%. Treatment for atonic bleeding and placenta previa (PP) showed similarly high success rates (97 and 94%, respectively). The rate of bleeding following Balloon insertion was significantly higher in failure than success cases (P =0.03) and all failure cases showed bleeding >250 mL/h. Conclusions: The "Balloon + holding the cervix" strategy achieved hemostasis in over 90% of primary PPH. Treatment: for not only atonic bleeding but also PP showed a high success rate. Bleeding >250 mL/h after Balloon insertion may indicate the requirement of additional invasive procedures. (C) 2017 Elsevier B.V. All rights reserved.
  • Hironori Takahashi, Teppei Matsubara, Shinji Makino, Kenji Horie, Shigeki Matsubara
    JOURNAL OF OBSTETRICS AND GYNAECOLOGY RESEARCH 43 (3) 592 - 594 1341-8076 2017/03 [Refereed][Not invited]
     
    Posterior reversible encephalopathy syndrome (PRES) is associated with several symptoms; of those, visual acuity loss, light oversensitivity (photophobia), and light flashes (photopsia) are known as PRES-related eye symptoms. We report a post-partum woman with PRES associated with hemolysis, elevated liver enzymes, and low platelets syndrome (HELLP), in whom color vision abnormality (achromatopsia) was the sole manifestation. Cesarean section was performed at 28 weeks due to headache, epigastralgia, and severe hypertension. HELLP became evident after delivery. On post-partum day 1, she complained of achromatopsia, stating: all things look brownish-gray. Ophthalmologic examination was normal, but brain magnetic resonance imaging showed occipital lobe lesions, indicative of PRES, and, interestingly, also color vision center (area V4) lesions, suggesting that the achromatopsia had been caused by brain damage. It may be prudent to question HELLP patients concerning achromatopsia.
  • Shigeki Matsubara, Hironori Takahashi, Yosuke Baba
    CARDIOVASCULAR AND INTERVENTIONAL RADIOLOGY 40 (3) 474 - 475 0174-1551 2017/03 [Refereed][Not invited]
  • Shigeki Matsubara, Hironori Takahashi, Yosuke Baba, Alan Kawarai Lefor
    CARDIOVASCULAR AND INTERVENTIONAL RADIOLOGY 40 (3) 478 - 479 0174-1551 2017/03 [Refereed][Not invited]
  • 新生児ヘモクロマトーシス児分娩既往妊婦に対する次回妊娠時の胎児大量ガンマグロブリン療法のIgG血中動態と有害事象調査 国内既実施8例において
    佐々木 愛子, 本村 健一郎, 天雲 千晶, 田中 宏和, 秦 利之, 高倉 正博, 藤原 浩, 高橋 宏典, 薄井 里英, 松原 茂樹, 左合 治彦
    日本産科婦人科学会雑誌 (公社)日本産科婦人科学会 69 (2) 655 - 655 0300-9165 2017/02
  • Hironori Takahashi, Akihide Ohkuchi, Tomoyuki Kuwata, Rie Usui, Yosuke Baba, Hirotada Suzuki, Tha Thu Chaw Kyi, Shigeki Matsubara, Shigeru Saito, Toshihiro Takizawa
    PLACENTA 50 25 - 31 0143-4004 2017/02 [Refereed][Not invited]
     
    Introduction: Adequate extravillous trophoblast (EVT) invasion is essential for successful placentation. Although miR-520c-3p plays an important role in CD44-mediated invasion in cancer cells, there is little information on whether miR-520c-3p is involved in the regulatory mechanisms of CD44-mediated EVT invasion. Methods: We screened first trimester trophoblast cells and trophoblast cell lines for expression of miR-520c-3p using real-time polymerase chain reaction. The cell invasion assay was performed using EVT cell lines, HTR8/SVneo and HChEpC1b, to investigate the capability of suppressing EVT invasion by miR-520c-3p. Laser microdissection analysis was then used to determine whether miR-520c-3p was present in the first trimester decidua. Finally, the possibility of chorionic villous trophoblast (CVT)-EVT communication via exosomal miR-520c-3p was determined using an in vitro model based on BeWo exosomes and the EVT cell lines as recipient cells. Results: The miR-520c-3p level was significantly downregulated in EVT cell lines and EVTs. Cell invasion was significantly inhibited in miR-520c-3p-overexpressing cell lines, involving a significant reduction of CD44. Laser microdissection analysis showed that miR-520c-3p in the periarterial area of the decidua was significantly higher than that in the non-periarterial area. Using an in vitro model system, BeWo exosomal miR-520c-3p was internalized into the EVT cells with subsequently reduced cell invasion via CD44 repression. Conclusions: EVT invasion is synergistically enhanced by the reciprocal expression of endogenous miR-520c-3p and CD44. The present study supports a novel model involving a placenta-associated miRNA function in cell-cell communication in which CVT exosomal miR-520c-3p regulates cell invasion by targeting CD44 in EVTs. (C) 2016 Elsevier Ltd. All rights reserved.
  • Manabu Ogoyama, Hironori Takahashi, Yukako Kobayashi, Rie Usui, Shigeki Matsubara
    JOURNAL OF OBSTETRICS AND GYNAECOLOGY RESEARCH 43 (2) 403 - 407 1341-8076 2017/02 [Refereed][Not invited]
     
    A primiparous pregnant woman in remission of myositis suffered very acute-onset ritodrine-induced rhabdomyolysis. At 29 gestational weeks, ritodrine was administered for threatened preterm labor. Just 3 h later, she complained of severe limb muscle pain, with serum creatinine phosphokinase elevated to 32019 U/L and myoglobinuria. The muscle pain disappeared immediately after ceasing administration of ritodrine. At 31 weeks, premature rupture of the membranes occurred, necessitating cesarean section, yielding a baby with weak tonus, and the presence of infantile muscle diseases was suspected. Genetic analysis of the infant confirmed myotonic dystrophy (dystrophia myotonica, DM), which prompted us to perform maternal genetic analysis, confirming maternal DM. Ritodrine can induce rhabdomyolysis even in the prodromal phase with a mild phenotype of DM. A literature review suggested that ritodrine-induced rhabdomyolysis may be likely to occur more acutely after ritodrine administration in DM compared with non-DM mothers.
  • H. Takahashi, R. Usui, H. Suzuki, Y. Baba, T. Suzuki, T. Kuwata, A. Ohkuchi, S. Matsubara
    CLINICAL AND EXPERIMENTAL OBSTETRICS & GYNECOLOGY 44 (1) 88 - 92 0390-6663 2017 [Refereed][Not invited]
     
    Purpose of investigation: Cesarean scar pregnancy (CSP) is a life-threatening condition that requires early pregnancy termination. Its early ultrasound diagnosis is clinically important; however, previous studies focused on the CSP site itself. The present study was conducted to investigate the authors' clinical impression that a uterine-fundal hypoechoic mass is more frequently observed in CSP. Such a finding, if confirmed, may contribute to ultrasound diagnosis of CSP. The authors also determined the relationship between the treatment strategy and outcome, with special emphasis on conditions eventually requiring uterine artery embolization (UAE). Materials and Methods: This was a case-control study of CSP, and the authors analyzed all 14 women that were treated in this single tertiary institute over a period of ten years. Control subjects consisted of all pregnant women with prior cesarean section (CS) but no CSP. Results: Patients with CSP were significantly more likely to have a hypoechoic mass than controls (42.9 vs. 15.4%, respectively; p = 0.028). On confining results to a "fundal" hypoechoic mass, only CSP(+) patients showed it (CSP vs. control: 28.6 vs. 0%, respectively; p < 0.001). Six (43%: 6/14) received UAE: four following vaginal evacuation (artificial or spontaneous), and two for bleeding after methotrexate (MTX) treatment. Conclusion: Patients with CSP more frequently had a uterine-fundal hypoechoic mass, whose detection may trigger a detailed observation of the CSP site, possibly leading to CSP diagnosis.
  • Shigeki Matsubara, Hironori Takahashi
    SCANDINAVIAN JOURNAL OF UROLOGY 51 (6) 496 - 497 2168-1805 2017 [Refereed][Not invited]
  • Kotomi Seno, Saoko Sase, Ayae Ozeki, Hironori Takahashi, Akihide Ohkuchi, Hirotada Suzuki, Shigeki Matsubara, Hisataka Iwata, Takehito Kuwayama, Koumei Shirasuna
    Journal of Reproduction and Development 63 (4) 401 - 408 1348-4400 2017 [Refereed][Not invited]
     
    Maternal obesity is a major risk factor for pregnancy complications, causing inflammatory cytokine release in the placenta, including interleukin-1β (IL-1β), IL-6, and IL-8. Pregnant women with obesity develop accelerated systemic and placental inflammation with elevated circulating advanced glycation end products (AGEs). IL-1β is a pivotal inflammatory cytokine associated with obesity and pregnancy complications, and its production is regulated by NLR family pyrin domain-containing 3 (NLRP3) inflammasomes. Here, we investigated whether AGEs are involved in the activation of NLRP3 inflammasomes using human placental tissues and placental cell line. In human placental tissue cultures, AGEs significantly increased IL-1β secretion, as well as IL-1β and NLRP3 mRNA expression. In human placental cell culture, although AGE treatment did not stimulate IL-1β secretion, AGEs significantly increased IL-1β mRNA expression and intracellular IL-1β production. After pre-incubation with AGEs, nano-silica treatment (well known as an inflammasome activator) increased IL-1β secretion in placental cells. However, after pre-incubation with lipopolysaccharide to produce pro-IL-1β, AGE treatment did not affect IL-1β secretion in placental cells. These findings suggest that AGEs stimulate pro-IL-1β production within placental cells, but do not activate inflammasomes to stimulate IL-1β secretion. Furthermore, using pharmacological inhibitors, we demonstrated that AGE-induced inflammatory cytokines are dependent on MAPK/NF-κB/AP-1 signaling and reactive oxygen species production in placental cells. In conclusion, AGEs regulate pro-IL-1β production and inflammatory responses, resulting in the activation of NLRP3 inflammasomes in human placenta. These results suggest that AGEs, as an endogenous and sterile danger signal, may contribute to chronic placental cytokine production.
  • Shigeki Matsubara, Hironori Takahashi, Miyuki Arai-Saruyama, Hanako Otachi, Kazumi Tada
    ACTA OBSTETRICIA ET GYNECOLOGICA SCANDINAVICA 96 (1) 128 - 129 0001-6349 2017/01 [Refereed][Not invited]
  • 【周産期医学必修知識第8版】 母子保健編 妊娠中、授乳中の薬の使い方
    高橋 宏典, 松原 茂樹
    周産期医学 (株)東京医学社 46 (増刊) 1132  0386-9881 2016/12 [Not refereed][Not invited]
  • 【周産期医学必修知識第8版】 産科編 帝王切開
    高橋 宏典, 松原 茂樹
    周産期医学 (株)東京医学社 46 (増刊) 380  0386-9881 2016/12 [Not refereed][Not invited]
  • 【周産期医学必修知識第8版】 母子保健編 妊娠中、授乳中の薬の使い方
    高橋 宏典, 松原 茂樹
    周産期医学 (株)東京医学社 46 (増刊) 1132  0386-9881 2016/12 [Not refereed][Not invited]
  • 【周産期医学必修知識第8版】 産科編 帝王切開
    高橋 宏典, 松原 茂樹
    周産期医学 (株)東京医学社 46 (増刊) 380  0386-9881 2016/12 [Not refereed][Not invited]
  • 【周産期医学必修知識第8版】 母子保健編 妊娠中、授乳中の薬の使い方
    高橋 宏典, 松原 茂樹
    周産期医学 (株)東京医学社 46 (増刊) 1132  0386-9881 2016/12 [Not refereed][Not invited]
  • 【周産期医学必修知識第8版】 産科編 帝王切開
    高橋 宏典, 松原 茂樹
    周産期医学 (株)東京医学社 46 (増刊) 380  0386-9881 2016/12 [Not refereed][Not invited]
  • 【周産期医学必修知識第8版】 母子保健編 妊娠中、授乳中の薬の使い方
    高橋 宏典, 松原 茂樹
    周産期医学 (株)東京医学社 46 (増刊) 1132  0386-9881 2016/12 [Not refereed][Not invited]
  • 【周産期医学必修知識第8版】 産科編 帝王切開
    高橋 宏典, 松原 茂樹
    周産期医学 (株)東京医学社 46 (増刊) 380  0386-9881 2016/12 [Not refereed][Not invited]
  • 【周産期医学必修知識第8版】 母子保健編 妊娠中、授乳中の薬の使い方
    高橋 宏典, 松原 茂樹
    周産期医学 (株)東京医学社 46 (増刊) 1132  0386-9881 2016/12 [Not refereed][Not invited]
  • 【周産期医学必修知識第8版】 産科編 帝王切開
    高橋 宏典, 松原 茂樹
    周産期医学 (株)東京医学社 46 (増刊) 380  0386-9881 2016/12 [Not refereed][Not invited]
  • 【周産期医学必修知識第8版】 母子保健編 妊娠中、授乳中の薬の使い方
    高橋 宏典, 松原 茂樹
    周産期医学 (株)東京医学社 46 (増刊) 1132  0386-9881 2016/12 [Not refereed][Not invited]
  • 【周産期医学必修知識第8版】 産科編 帝王切開
    高橋 宏典, 松原 茂樹
    周産期医学 (株)東京医学社 46 (増刊) 380  0386-9881 2016/12 [Not refereed][Not invited]
  • 【周産期医学必修知識第8版】 母子保健編 妊娠中、授乳中の薬の使い方
    高橋 宏典, 松原 茂樹
    周産期医学 (株)東京医学社 46 (増刊) 1132  0386-9881 2016/12 [Not refereed][Not invited]
  • 【周産期医学必修知識第8版】 産科編 帝王切開
    高橋 宏典, 松原 茂樹
    周産期医学 (株)東京医学社 46 (増刊) 380  0386-9881 2016/12 [Not refereed][Not invited]
  • 【周産期医学必修知識第8版】 母子保健編 妊娠中、授乳中の薬の使い方
    高橋 宏典, 松原 茂樹
    周産期医学 (株)東京医学社 46 (増刊) 1132  0386-9881 2016/12 [Not refereed][Not invited]
  • 【周産期医学必修知識第8版】 産科編 帝王切開
    高橋 宏典, 松原 茂樹
    周産期医学 (株)東京医学社 46 (増刊) 380  0386-9881 2016/12 [Not refereed][Not invited]
  • 【周産期医学必修知識第8版】 母子保健編 妊娠中、授乳中の薬の使い方
    高橋 宏典, 松原 茂樹
    周産期医学 (株)東京医学社 46 (増刊) 1132  0386-9881 2016/12 [Not refereed][Not invited]
  • 【周産期医学必修知識第8版】 産科編 帝王切開
    高橋 宏典, 松原 茂樹
    周産期医学 (株)東京医学社 46 (増刊) 380  0386-9881 2016/12 [Not refereed][Not invited]
  • 【周産期医学必修知識第8版】 母子保健編 妊娠中、授乳中の薬の使い方
    高橋 宏典, 松原 茂樹
    周産期医学 (株)東京医学社 46 (増刊) 1132  0386-9881 2016/12 [Not refereed][Not invited]
  • 【周産期医学必修知識第8版】 産科編 帝王切開
    高橋 宏典, 松原 茂樹
    周産期医学 (株)東京医学社 46 (増刊) 380  0386-9881 2016/12 [Not refereed][Not invited]
  • 【周産期医学必修知識第8版】 母子保健編 妊娠中、授乳中の薬の使い方
    高橋 宏典, 松原 茂樹
    周産期医学 (株)東京医学社 46 (増刊) 1132  0386-9881 2016/12 [Not refereed][Not invited]
  • 【周産期医学必修知識第8版】 産科編 帝王切開
    高橋 宏典, 松原 茂樹
    周産期医学 (株)東京医学社 46 (増刊) 380  0386-9881 2016/12 [Not refereed][Not invited]
  • 【周産期医学必修知識第8版】 母子保健編 妊娠中、授乳中の薬の使い方
    高橋 宏典, 松原 茂樹
    周産期医学 (株)東京医学社 46 (増刊) 1132  0386-9881 2016/12 [Not refereed][Not invited]
  • 【周産期医学必修知識第8版】 産科編 帝王切開
    高橋 宏典, 松原 茂樹
    周産期医学 (株)東京医学社 46 (増刊) 380  0386-9881 2016/12 [Not refereed][Not invited]
  • 【周産期医学必修知識第8版】 母子保健編 妊娠中、授乳中の薬の使い方
    高橋 宏典, 松原 茂樹
    周産期医学 (株)東京医学社 46 (増刊) 1132  0386-9881 2016/12 [Not refereed][Not invited]
  • 【周産期医学必修知識第8版】 産科編 帝王切開
    高橋 宏典, 松原 茂樹
    周産期医学 (株)東京医学社 46 (増刊) 380  0386-9881 2016/12 [Not refereed][Not invited]
  • Matsubara S, Takahashi H, Lefor AK
    American journal of obstetrics and gynecology 0002-9378 2016/12 [Refereed][Not invited]
  • Shigeki Matsubara, Hirotada Suzuki, Yosuke Baba, Hironori Takahashi, Hisanori Minakami
    ACTA OBSTETRICIA ET GYNECOLOGICA SCANDINAVICA 95 (12) 1448 - 1448 0001-6349 2016/12 [Refereed][Not invited]
  • 【周産期医学必修知識第8版】 母子保健編 妊娠中、授乳中の薬の使い方
    高橋 宏典, 松原 茂樹
    周産期医学 (株)東京医学社 46 (増刊) 1132  0386-9881 2016/12 [Not refereed][Not invited]
  • 【周産期医学必修知識第8版】 産科編 帝王切開
    高橋 宏典, 松原 茂樹
    周産期医学 (株)東京医学社 46 (増刊) 380  0386-9881 2016/12 [Not refereed][Not invited]
  • Akihide Ohkuchi, Chikako Hirashima, Shiho Nagayama, Kayo Takahashi, Hirotada Suzuki, Hironori Takahashi, Shigeki Matsubara
    JOURNAL OF REPRODUCTIVE IMMUNOLOGY 118 137 - 137 0165-0378 2016/11 [Refereed][Not invited]
  • Takahashi Hironori, Matsubara Shigeki
    The Journal of Obstetrics and Gynaecology Research Wiley Publishing Asia Pty Ltd 42 (11) 1629  1341-8076 2016/11 [Not refereed][Not invited]
  • Takahashi Hironori, Matsubara Shigeki
    The Journal of Obstetrics and Gynaecology Research Wiley Publishing Asia Pty Ltd 42 (11) 1629  1341-8076 2016/11 [Not refereed][Not invited]
  • Baba Yosuke, Takahashi Hironori, Ohkuchi Akihide, Usui Rie, Matsubara Shigeki
    The Journal of Obstetrics and Gynaecology Research Wiley Publishing Asia Pty Ltd 42 (11) 1502  1341-8076 2016/11 [Not refereed][Not invited]
  • Takahashi Hironori, Matsubara Shigeki
    The Journal of Obstetrics and Gynaecology Research Wiley Publishing Asia Pty Ltd 42 (11) 1629  1341-8076 2016/11 [Not refereed][Not invited]
  • Takahashi Hironori, Matsubara Shigeki
    The Journal of Obstetrics and Gynaecology Research Wiley Publishing Asia Pty Ltd 42 (11) 1629  1341-8076 2016/11 [Not refereed][Not invited]
  • Baba Yosuke, Takahashi Hironori, Ohkuchi Akihide, Usui Rie, Matsubara Shigeki
    The Journal of Obstetrics and Gynaecology Research Wiley Publishing Asia Pty Ltd 42 (11) 1502  1341-8076 2016/11 [Not refereed][Not invited]
  • Takahashi Hironori, Matsubara Shigeki
    The Journal of Obstetrics and Gynaecology Research Wiley Publishing Asia Pty Ltd 42 (11) 1629  1341-8076 2016/11 [Not refereed][Not invited]
  • Takahashi Hironori, Matsubara Shigeki
    The Journal of Obstetrics and Gynaecology Research Wiley Publishing Asia Pty Ltd 42 (11) 1629  1341-8076 2016/11 [Not refereed][Not invited]
  • Baba Yosuke, Takahashi Hironori, Ohkuchi Akihide, Usui Rie, Matsubara Shigeki
    The Journal of Obstetrics and Gynaecology Research Wiley Publishing Asia Pty Ltd 42 (11) 1502  1341-8076 2016/11 [Not refereed][Not invited]
  • Takahashi Hironori, Matsubara Shigeki
    The Journal of Obstetrics and Gynaecology Research Wiley Publishing Asia Pty Ltd 42 (11) 1629  1341-8076 2016/11 [Not refereed][Not invited]
  • Takahashi Hironori, Matsubara Shigeki
    The Journal of Obstetrics and Gynaecology Research Wiley Publishing Asia Pty Ltd 42 (11) 1629  1341-8076 2016/11 [Not refereed][Not invited]
  • Baba Yosuke, Takahashi Hironori, Ohkuchi Akihide, Usui Rie, Matsubara Shigeki
    The Journal of Obstetrics and Gynaecology Research Wiley Publishing Asia Pty Ltd 42 (11) 1502  1341-8076 2016/11 [Not refereed][Not invited]
  • Hironori Takahashi, Shigeki Matsubara
    JOURNAL OF OBSTETRICS AND GYNAECOLOGY RESEARCH Wiley Publishing Asia Pty Ltd 42 (11) 1629 - 1630 1341-8076 2016/11 [Not refereed][Not invited]
  • Takahashi Hironori, Matsubara Shigeki
    The Journal of Obstetrics and Gynaecology Research Wiley Publishing Asia Pty Ltd 42 (11) 1629  1341-8076 2016/11 [Not refereed][Not invited]
  • Baba Yosuke, Takahashi Hironori, Ohkuchi Akihide, Usui Rie, Matsubara Shigeki
    The Journal of Obstetrics and Gynaecology Research Wiley Publishing Asia Pty Ltd 42 (11) 1502  1341-8076 2016/11 [Not refereed][Not invited]
  • Takahashi Hironori, Matsubara Shigeki
    The Journal of Obstetrics and Gynaecology Research Wiley Publishing Asia Pty Ltd 42 (11) 1629  1341-8076 2016/11 [Not refereed][Not invited]
  • Takahashi Hironori, Matsubara Shigeki
    The Journal of Obstetrics and Gynaecology Research Wiley Publishing Asia Pty Ltd 42 (11) 1629  1341-8076 2016/11 [Not refereed][Not invited]
  • Baba Yosuke, Takahashi Hironori, Ohkuchi Akihide, Usui Rie, Matsubara Shigeki
    The Journal of Obstetrics and Gynaecology Research Wiley Publishing Asia Pty Ltd 42 (11) 1502  1341-8076 2016/11 [Not refereed][Not invited]
  • Takahashi Hironori, Matsubara Shigeki
    The Journal of Obstetrics and Gynaecology Research Wiley Publishing Asia Pty Ltd 42 (11) 1629  1341-8076 2016/11 [Not refereed][Not invited]
  • Takahashi Hironori, Matsubara Shigeki
    The Journal of Obstetrics and Gynaecology Research Wiley Publishing Asia Pty Ltd 42 (11) 1629  1341-8076 2016/11 [Not refereed][Not invited]
  • Baba Yosuke, Takahashi Hironori, Ohkuchi Akihide, Usui Rie, Matsubara Shigeki
    The Journal of Obstetrics and Gynaecology Research Wiley Publishing Asia Pty Ltd 42 (11) 1502  1341-8076 2016/11 [Not refereed][Not invited]
  • Takahashi Hironori, Matsubara Shigeki
    The Journal of Obstetrics and Gynaecology Research Wiley Publishing Asia Pty Ltd 42 (11) 1629  1341-8076 2016/11 [Not refereed][Not invited]
  • Takahashi Hironori, Matsubara Shigeki
    The Journal of Obstetrics and Gynaecology Research Wiley Publishing Asia Pty Ltd 42 (11) 1629  1341-8076 2016/11 [Not refereed][Not invited]
  • Yosuke Baba, Hironori Takahashi, Akihide Ohkuchi, Rie Usui, Shigeki Matsubara
    JOURNAL OF OBSTETRICS AND GYNAECOLOGY RESEARCH Wiley Publishing Asia Pty Ltd 42 (11) 1502 - 1508 1341-8076 2016/11 [Not refereed][Not invited]
     
    AimDuring cesarean section (CS) for placenta previa (PP), the size/area/portion of the lower uterine segment occupied by the placenta may affect the bleeding amount and the subsequent need for a blood transfusion (BT). We propose a new concept, indiscernible edge total PP (IEPP), when vaginal ultrasound does not discern the lower placental edge because the placenta covers the visible lower segment. We characterized IEPP, focusing on its allogeneic BT requirement. MethodsWe classified PP (n = 307) into four types: marginal, partial, discernible edge total PP (DEPP) and IEPP: internal ostium (os)-placental edge distance measurable or unmeasurable on vaginal ultrasound in DEPP or IEPP, respectively. We determined the clinical characteristics according to the four types; the relationship between the intraoperative blood loss and os-edge distance in DEPP; and risk factors for allogeneic BT. ResultsThe following were significantly higher/larger in cases of IEPP: previous CS; anterior placentation; lacunae; elective cesarean hysterectomy; intraoperative blood loss; autologous BT; allogeneic BT; intensive care unit admission; and an abnormally invasive placenta (AIP). In DEPP, the os-edge distance was weakly correlated with the bleeding amount (r = 0.214). Multivariate logistic regression analysis showed that previous CS, lacunae, AIP and IEPP were independent risk factors for allogeneic BT (odds ratios 3.8, 3.1, 13.8 and 4.6, respectively). After excluding patients undergoing hemostatic procedures during CS, IEPP remained the only independent risk factor for allogeneic BT (odds ratio 5.2). ConclusionsThe new concept of IEPP may be useful for predicting BT in CS for patients with PP.
  • Takahashi Hironori, Matsubara Shigeki
    The Journal of Obstetrics and Gynaecology Research Wiley Publishing Asia Pty Ltd 42 (11) 1629  1341-8076 2016/11 [Not refereed][Not invited]
  • Baba Yosuke, Takahashi Hironori, Ohkuchi Akihide, Usui Rie, Matsubara Shigeki
    The Journal of Obstetrics and Gynaecology Research Wiley Publishing Asia Pty Ltd 42 (11) 1502  1341-8076 2016/11 [Not refereed][Not invited]
  • Recurrent uterine artery pseudoaneurysm(和訳中)
    Takahashi Hironori, Matsubara Shigeki
    The Journal of Obstetrics and Gynaecology Research Wiley Publishing Asia Pty Ltd 42 (11) 1629  1341-8076 2016/11 [Not refereed][Not invited]
  • Recurrent uterine artery pseudoaneurysm(和訳中)
    Takahashi Hironori, Matsubara Shigeki
    The Journal of Obstetrics and Gynaecology Research Wiley Publishing Asia Pty Ltd 42 (11) 1629  1341-8076 2016/11 [Not refereed][Not invited]
  • Which type of placenta previa requires blood transfusion more frequently? A new concept of indiscernible edge total previa(和訳中)
    Baba Yosuke, Takahashi Hironori, Ohkuchi Akihide, Usui Rie, Matsubara Shigeki
    The Journal of Obstetrics and Gynaecology Research Wiley Publishing Asia Pty Ltd 42 (11) 1502  1341-8076 2016/11 [Not refereed][Not invited]
  • Takahashi Hironori, Matsubara Shigeki
    The Journal of Obstetrics and Gynaecology Research Wiley Publishing Asia Pty Ltd 42 (11) 1629  1341-8076 2016/11 [Not refereed][Not invited]
  • Baba Yosuke, Takahashi Hironori, Ohkuchi Akihide, Usui Rie, Matsubara Shigeki
    The Journal of Obstetrics and Gynaecology Research Wiley Publishing Asia Pty Ltd 42 (11) 1502  1341-8076 2016/11 [Not refereed][Not invited]
  • Takahashi Hironori, Matsubara Shigeki
    The Journal of Obstetrics and Gynaecology Research Wiley Publishing Asia Pty Ltd 42 (11) 1629  1341-8076 2016/11 [Not refereed][Not invited]
  • Yosuke Baba, Hironori Takahashi, Akihide Ohkuchi, Rie Usui, Shigeki Matsubara
    Journal of Obstetrics and Gynaecology Research Wiley Publishing Asia Pty Ltd 42 (11) 1502 - 1508 1447-0756 2016/11 [Not refereed][Not invited]
     
    Aim: During cesarean section (CS) for placenta previa (PP), the size/area/portion of the lower uterine segment occupied by the placenta may affect the bleeding amount and the subsequent need for a blood transfusion (BT). We propose a new concept, indiscernible edge total PP (IEPP), when vaginal ultrasound does not discern the lower placental edge because the placenta covers the visible lower segment. We characterized IEPP, focusing on its allogeneic BT requirement. Methods: We classified PP (n = 307) into four types: marginal, partial, discernible edge total PP (DEPP) and IEPP: internal ostium (os)-placental edge distance measurable or unmeasurable on vaginal ultrasound in DEPP or IEPP, respectively. We determined the clinical characteristics according to the four types the relationship between the intraoperative blood loss and os-edge distance in DEPP and risk factors for allogeneic BT. Results: The following were significantly higher/larger in cases of IEPP: previous CS anterior placentation lacunae elective cesarean hysterectomy intraoperative blood loss autologous BT allogeneic BT intensive care unit admission and an abnormally invasive placenta (AIP). In DEPP, the os-edge distance was weakly correlated with the bleeding amount (r = 0.214). Multivariate logistic regression analysis showed that previous CS, lacunae, AIP and IEPP were independent risk factors for allogeneic BT (odds ratios 3.8, 3.1, 13.8 and 4.6, respectively). After excluding patients undergoing hemostatic procedures during CS, IEPP remained the only independent risk factor for allogeneic BT (odds ratio 5.2). Conclusions: The new concept of IEPP may be useful for predicting BT in CS for patients with PP.
  • Recurrent uterine artery pseudoaneurysm(和訳中)
    Takahashi Hironori, Matsubara Shigeki
    The Journal of Obstetrics and Gynaecology Research Wiley Publishing Asia Pty Ltd 42 (11) 1629  1341-8076 2016/11 [Not refereed][Not invited]
  • Recurrent uterine artery pseudoaneurysm(和訳中)
    Takahashi Hironori, Matsubara Shigeki
    The Journal of Obstetrics and Gynaecology Research Wiley Publishing Asia Pty Ltd 42 (11) 1629  1341-8076 2016/11 [Not refereed][Not invited]
  • Which type of placenta previa requires blood transfusion more frequently? A new concept of indiscernible edge total previa(和訳中)
    Baba Yosuke, Takahashi Hironori, Ohkuchi Akihide, Usui Rie, Matsubara Shigeki
    The Journal of Obstetrics and Gynaecology Research Wiley Publishing Asia Pty Ltd 42 (11) 1502  1341-8076 2016/11 [Not refereed][Not invited]
  • Hironori Takahashi, Shigeki Matsubara
    Journal of Obstetrics and Gynaecology Research 42 (11) 1629 - 1630 1447-0756 2016/11 [Refereed][Not invited]
  • Hirotada Suzuki, Hironori Takahashi, Madoka Kimura, Hiroyasu Nakamura, Rie Usui, Shigeki Matsubara
    JOURNAL OF OBSTETRICS AND GYNAECOLOGY 36 (8) 999 - 1001 0144-3615 2016/11 [Refereed][Not invited]
  • Shigeki Matsubara, Hironori Takahashi, Tomoyuki Kuwata, Rie Usui, Alan K. Lefor
    EUROPEAN JOURNAL OF OBSTETRICS & GYNECOLOGY AND REPRODUCTIVE BIOLOGY 206 245 - 246 0301-2115 2016/11 [Refereed][Not invited]
  • Takahashi Hironori, Matsubara Shigeki
    The Journal of Obstetrics and Gynaecology Research Wiley Publishing Asia Pty Ltd 42 (11) 1629  1341-8076 2016/11 [Not refereed][Not invited]
  • Takahashi Hironori, Matsubara Shigeki
    The Journal of Obstetrics and Gynaecology Research Wiley Publishing Asia Pty Ltd 42 (11) 1629  1341-8076 2016/11 [Not refereed][Not invited]
  • Baba Yosuke, Takahashi Hironori, Ohkuchi Akihide, Usui Rie, Matsubara Shigeki
    The Journal of Obstetrics and Gynaecology Research Wiley Publishing Asia Pty Ltd 42 (11) 1502  1341-8076 2016/11 [Not refereed][Not invited]
  • Differential expression of microRNA between human first trimester villous and extravillous trophoblast cells: PCR array-based approach(和訳中)
    Takahashi Hironori, Ohkuchi Akihide, Ishida Yoichi, Takizawa Toshihiro, Matsubara Shigeki
    The Journal of Obstetrics and Gynaecology Research Wiley Publishing Asia Pty Ltd 42 (Suppl.1) 13  1341-8076 2016/10 [Not refereed][Not invited]
  • Matsubara Shigeki, Takahashi Hironori, Usui Rie
    The Journal of Obstetrics and Gynaecology Research Wiley Publishing Asia Pty Ltd 42 (10) 1412  1341-8076 2016/10 [Not refereed][Not invited]
  • Tomoyuki Kuwata, Hironori Takahashi, Harumi Koibuchi, Kiyotake Ichizuka, Michiya Natori, Shigeki Matsubara
    JOURNAL OF MEDICAL ULTRASONICS シュプリンガー・ジャパン(株) 43 (4) 505 - 508 1346-4523 2016/10 [Not refereed][Not invited]
     
    To clarify the present status of human papillomavirus (HPV) contamination of transvaginal probes in Japan and propose a preventive method. This study was performed at three institutes: a tertiary center, secondary hospital, and primary facility. To identify contamination rates, probes were disinfected and covered with probe covers and condoms; the cover was changed for each patient. The probes were tested for HPV, and those with HPV detected were analyzed to identify the type of HPV. Next, nurses put on new gloves before covering the probe for each patient, and the probes were similarly tested for HPV. A total of 120 probes were tested, and HPV was detected from a total of five probes, a contamination rate of 4.2 % (5/120). HPV was detected in all three institutes. Importantly, high-risk HPV, i.e., HPV-52, 56, and 59, was detected. After the "glove change strategy" was implemented, HPV was not detected on any of 150 probes tested at any of the three institutions. In Japan, the HPV contamination rate of vaginal probes in routine practice was 4.2 %. There was no HPV contamination of probes after changing the gloves for cover exchange for each patient. This strategy may prevent HPV probe contamination.
  • Okada Noriki, Ihara Yoshiyuki, Urahashi Taizen, Sanada Yukihiro, Yamada Naoya, Hirata Yuta, Tashiro Masahisa, Katano Takumi, Ushijima Kentaro, Otomo Shinya, Takahashi Hironori, Matsubara Shigeki, Mizuta Koichi
    Pediatrics International Wiley Publishing Asia Pty Ltd 58 (10) 1059  1328-8067 2016/10 [Not refereed][Not invited]
  • Differential expression of microRNA between human first trimester villous and extravillous trophoblast cells: PCR array-based approach(和訳中)
    Takahashi Hironori, Ohkuchi Akihide, Ishida Yoichi, Takizawa Toshihiro, Matsubara Shigeki
    The Journal of Obstetrics and Gynaecology Research Wiley Publishing Asia Pty Ltd 42 (Suppl.1) 13  1341-8076 2016/10 [Not refereed][Not invited]
  • Matsubara Shigeki, Takahashi Hironori, Usui Rie
    The Journal of Obstetrics and Gynaecology Research Wiley Publishing Asia Pty Ltd 42 (10) 1412  1341-8076 2016/10 [Not refereed][Not invited]
  • Kuwata Tomoyuki, Takahashi Hironori, Koibuchi Harumi, Ichizuka Kiyotake, Natori Michiya, Matsubara Shigeki
    Journal of Medical Ultrasonics シュプリンガー・ジャパン(株) 43 (4) 505  1346-4523 2016/10 [Not refereed][Not invited]
  • Okada Noriki, Ihara Yoshiyuki, Urahashi Taizen, Sanada Yukihiro, Yamada Naoya, Hirata Yuta, Tashiro Masahisa, Katano Takumi, Ushijima Kentaro, Otomo Shinya, Takahashi Hironori, Matsubara Shigeki, Mizuta Koichi
    Pediatrics International Wiley Publishing Asia Pty Ltd 58 (10) 1059  1328-8067 2016/10 [Not refereed][Not invited]
  • Differential expression of microRNA between human first trimester villous and extravillous trophoblast cells: PCR array-based approach(和訳中)
    Takahashi Hironori, Ohkuchi Akihide, Ishida Yoichi, Takizawa Toshihiro, Matsubara Shigeki
    The Journal of Obstetrics and Gynaecology Research Wiley Publishing Asia Pty Ltd 42 (Suppl.1) 13  1341-8076 2016/10 [Not refereed][Not invited]
  • Matsubara Shigeki, Takahashi Hironori, Usui Rie
    The Journal of Obstetrics and Gynaecology Research Wiley Publishing Asia Pty Ltd 42 (10) 1412  1341-8076 2016/10 [Not refereed][Not invited]
  • Kuwata Tomoyuki, Takahashi Hironori, Koibuchi Harumi, Ichizuka Kiyotake, Natori Michiya, Matsubara Shigeki
    Journal of Medical Ultrasonics シュプリンガー・ジャパン(株) 43 (4) 505  1346-4523 2016/10 [Not refereed][Not invited]
  • Okada Noriki, Ihara Yoshiyuki, Urahashi Taizen, Sanada Yukihiro, Yamada Naoya, Hirata Yuta, Tashiro Masahisa, Katano Takumi, Ushijima Kentaro, Otomo Shinya, Takahashi Hironori, Matsubara Shigeki, Mizuta Koichi
    Pediatrics International Wiley Publishing Asia Pty Ltd 58 (10) 1059  1328-8067 2016/10 [Not refereed][Not invited]
  • Differential expression of microRNA between human first trimester villous and extravillous trophoblast cells: PCR array-based approach(和訳中)
    Takahashi Hironori, Ohkuchi Akihide, Ishida Yoichi, Takizawa Toshihiro, Matsubara Shigeki
    The Journal of Obstetrics and Gynaecology Research Wiley Publishing Asia Pty Ltd 42 (Suppl.1) 13  1341-8076 2016/10 [Not refereed][Not invited]
  • Matsubara Shigeki, Takahashi Hironori, Usui Rie
    The Journal of Obstetrics and Gynaecology Research Wiley Publishing Asia Pty Ltd 42 (10) 1412  1341-8076 2016/10 [Not refereed][Not invited]
  • Kuwata Tomoyuki, Takahashi Hironori, Koibuchi Harumi, Ichizuka Kiyotake, Natori Michiya, Matsubara Shigeki
    Journal of Medical Ultrasonics シュプリンガー・ジャパン(株) 43 (4) 505  1346-4523 2016/10 [Not refereed][Not invited]
  • Okada Noriki, Ihara Yoshiyuki, Urahashi Taizen, Sanada Yukihiro, Yamada Naoya, Hirata Yuta, Tashiro Masahisa, Katano Takumi, Ushijima Kentaro, Otomo Shinya, Takahashi Hironori, Matsubara Shigeki, Mizuta Koichi
    Pediatrics International Wiley Publishing Asia Pty Ltd 58 (10) 1059  1328-8067 2016/10 [Not refereed][Not invited]
  • Differential expression of microRNA between human first trimester villous and extravillous trophoblast cells: PCR array-based approach(和訳中)
    Takahashi Hironori, Ohkuchi Akihide, Ishida Yoichi, Takizawa Toshihiro, Matsubara Shigeki
    The Journal of Obstetrics and Gynaecology Research Wiley Publishing Asia Pty Ltd 42 (Suppl.1) 13  1341-8076 2016/10 [Not refereed][Not invited]
  • Shigeki Matsubara, Hironori Takahashi, Rie Usui
    JOURNAL OF OBSTETRICS AND GYNAECOLOGY RESEARCH Wiley Publishing Asia Pty Ltd 42 (10) 1412 - 1413 1341-8076 2016/10 [Not refereed][Not invited]
  • Kuwata Tomoyuki, Takahashi Hironori, Koibuchi Harumi, Ichizuka Kiyotake, Natori Michiya, Matsubara Shigeki
    Journal of Medical Ultrasonics シュプリンガー・ジャパン(株) 43 (4) 505  1346-4523 2016/10 [Not refereed][Not invited]
  • Okada Noriki, Ihara Yoshiyuki, Urahashi Taizen, Sanada Yukihiro, Yamada Naoya, Hirata Yuta, Tashiro Masahisa, Katano Takumi, Ushijima Kentaro, Otomo Shinya, Takahashi Hironori, Matsubara Shigeki, Mizuta Koichi
    Pediatrics International Wiley Publishing Asia Pty Ltd 58 (10) 1059  1328-8067 2016/10 [Not refereed][Not invited]
  • Differential expression of microRNA between human first trimester villous and extravillous trophoblast cells: PCR array-based approach(和訳中)
    Takahashi Hironori, Ohkuchi Akihide, Ishida Yoichi, Takizawa Toshihiro, Matsubara Shigeki
    The Journal of Obstetrics and Gynaecology Research Wiley Publishing Asia Pty Ltd 42 (Suppl.1) 13  1341-8076 2016/10 [Not refereed][Not invited]
  • Matsubara Shigeki, Takahashi Hironori, Usui Rie
    The Journal of Obstetrics and Gynaecology Research Wiley Publishing Asia Pty Ltd 42 (10) 1412  1341-8076 2016/10 [Not refereed][Not invited]
  • Kuwata Tomoyuki, Takahashi Hironori, Koibuchi Harumi, Ichizuka Kiyotake, Natori Michiya, Matsubara Shigeki
    Journal of Medical Ultrasonics シュプリンガー・ジャパン(株) 43 (4) 505  1346-4523 2016/10 [Not refereed][Not invited]
  • Okada Noriki, Ihara Yoshiyuki, Urahashi Taizen, Sanada Yukihiro, Yamada Naoya, Hirata Yuta, Tashiro Masahisa, Katano Takumi, Ushijima Kentaro, Otomo Shinya, Takahashi Hironori, Matsubara Shigeki, Mizuta Koichi
    Pediatrics International Wiley Publishing Asia Pty Ltd 58 (10) 1059  1328-8067 2016/10 [Not refereed][Not invited]
  • Differential expression of microRNA between human first trimester villous and extravillous trophoblast cells: PCR array-based approach(和訳中)
    Takahashi Hironori, Ohkuchi Akihide, Ishida Yoichi, Takizawa Toshihiro, Matsubara Shigeki
    The Journal of Obstetrics and Gynaecology Research Wiley Publishing Asia Pty Ltd 42 (Suppl.1) 13  1341-8076 2016/10 [Not refereed][Not invited]
  • Matsubara Shigeki, Takahashi Hironori, Usui Rie
    The Journal of Obstetrics and Gynaecology Research Wiley Publishing Asia Pty Ltd 42 (10) 1412  1341-8076 2016/10 [Not refereed][Not invited]
  • Kuwata Tomoyuki, Takahashi Hironori, Koibuchi Harumi, Ichizuka Kiyotake, Natori Michiya, Matsubara Shigeki
    Journal of Medical Ultrasonics シュプリンガー・ジャパン(株) 43 (4) 505  1346-4523 2016/10 [Not refereed][Not invited]
  • Okada Noriki, Ihara Yoshiyuki, Urahashi Taizen, Sanada Yukihiro, Yamada Naoya, Hirata Yuta, Tashiro Masahisa, Katano Takumi, Ushijima Kentaro, Otomo Shinya, Takahashi Hironori, Matsubara Shigeki, Mizuta Koichi
    Pediatrics International Wiley Publishing Asia Pty Ltd 58 (10) 1059  1328-8067 2016/10 [Not refereed][Not invited]
  • Differential expression of microRNA between human first trimester villous and extravillous trophoblast cells: PCR array-based approach(和訳中)
    Takahashi Hironori, Ohkuchi Akihide, Ishida Yoichi, Takizawa Toshihiro, Matsubara Shigeki
    The Journal of Obstetrics and Gynaecology Research Wiley Publishing Asia Pty Ltd 42 (Suppl.1) 13  1341-8076 2016/10 [Not refereed][Not invited]
  • Matsubara Shigeki, Takahashi Hironori, Usui Rie
    The Journal of Obstetrics and Gynaecology Research Wiley Publishing Asia Pty Ltd 42 (10) 1412  1341-8076 2016/10 [Not refereed][Not invited]
  • Kuwata Tomoyuki, Takahashi Hironori, Koibuchi Harumi, Ichizuka Kiyotake, Natori Michiya, Matsubara Shigeki
    Journal of Medical Ultrasonics シュプリンガー・ジャパン(株) 43 (4) 505  1346-4523 2016/10 [Not refereed][Not invited]
  • Okada Noriki, Ihara Yoshiyuki, Urahashi Taizen, Sanada Yukihiro, Yamada Naoya, Hirata Yuta, Tashiro Masahisa, Katano Takumi, Ushijima Kentaro, Otomo Shinya, Takahashi Hironori, Matsubara Shigeki, Mizuta Koichi
    Pediatrics International Wiley Publishing Asia Pty Ltd 58 (10) 1059  1328-8067 2016/10 [Not refereed][Not invited]
  • Differential expression of microRNA between human first trimester villous and extravillous trophoblast cells: PCR array-based approach(和訳中)
    Takahashi Hironori, Ohkuchi Akihide, Ishida Yoichi, Takizawa Toshihiro, Matsubara Shigeki
    The Journal of Obstetrics and Gynaecology Research Wiley Publishing Asia Pty Ltd 42 (Suppl.1) 13  1341-8076 2016/10 [Not refereed][Not invited]
  • Matsubara Shigeki, Takahashi Hironori, Usui Rie
    The Journal of Obstetrics and Gynaecology Research Wiley Publishing Asia Pty Ltd 42 (10) 1412  1341-8076 2016/10 [Not refereed][Not invited]
  • Kuwata Tomoyuki, Takahashi Hironori, Koibuchi Harumi, Ichizuka Kiyotake, Natori Michiya, Matsubara Shigeki
    Journal of Medical Ultrasonics シュプリンガー・ジャパン(株) 43 (4) 505  1346-4523 2016/10 [Not refereed][Not invited]
  • Noriki Okada, Yoshiyuki Ihara, Taizen Urahashi, Yukihiro Sanada, Naoya Yamada, Yuta Hirata, Masahisa Tashiro, Takumi Katano, Kentaro Ushijima, Shinya Otomo, Hironori Takahashi, Shigeki Matsubara, Koichi Mizuta
    Pediatrics International Wiley Publishing Asia Pty Ltd 58 (10) 1059 - 1061 1442-200X 2016/10 [Not refereed][Not invited]
     
    Neonatal hemochromatosis (NH) is a rare disease with a poor prognosis, particularly prior to 2008. Antenatal maternal high-dose immunoglobulin (Ig) is effective in preventing NH recurrence, but the adverse effects of this treatment have not been documented as yet. Here, we report on a patient who underwent high-dose Ig treatment to prevent NH recurrence. The patient was a 31-year-old pregnant Japanese woman. Her first child died of NH after receiving living donor liver transplantation. The patient received high-dose Ig treatment to prevent recurrence of NH from gestational weeks 16 to 35. During the treatment, platelet count gradually decreased, and cesarean section was required at 35 gestational weeks. The child did not develop liver failure. High-dose Ig prevented the recurrence of NH. Caution should be exercised due to possible adverse effects of this treatment.
  • Yosuke Baba, Hironori Takahashi, Akihide Ohkuchi, Hirotada Suzuki, Tomoyuki Kuwata, Rie Usui, Miyuki Saruyama, Manabu Ogoyama, Shiho Nagayama, Hiroyasu Nakamura, Atsushi Ugajin, Shigeki Matsubara
    EUROPEAN JOURNAL OF OBSTETRICS & GYNECOLOGY AND REPRODUCTIVE BIOLOGY 205 72 - 78 0301-2115 2016/10 [Refereed][Not invited]
     
    Objectives: Uterine artery pseudoaneurysm (UAP) has been considered to occur very rarely after traumatic delivery/abortion, and is usually detected after its rupture, yielding massive bleeding. Our hypothesis is: some UAP may be undetected without massive bleeding and may spontaneously resolve, and, thus, may not require transarterial embolization (TAE). We attempted: (1) to detect both ruptured and non-ruptured UAP, thereby characterizing candidates of spontaneously resolving UAP, and (2) to confirm that UAP is not rare and not always associated with traumatic events. Study design: This was a retrospective observational study of 50 women with angiographically confirmed UAP and treated by TAE. Angiograms and medical charts were retrieved to examine the associations among symptoms, ultrasound findings, and extravasation. Gray-scale ultrasound was performed for all women after delivery or abortion as our routine practice. Results: UAP occurred in 3-6/1000 deliveries and 40% occurred after non-traumatic deliveries/abortion. While 36% had active vaginal bleeding at admission, 64% did not. While 100% of patients with current active bleeding showed extravasation from the pseudoaneurysmal sac, patients without it showed a varied incidence of extravasation depending on the bleeding pattern/history and ultrasound findings. Interestingly, all patients with current bleeding (-), bleeding history (+), and ultrasound-discernable intrauterine low echoic mass (-) were devoid of extravasation, suggesting that UAP may show progression to thrombosis and, thus, resolve spontaneously. Conclusions: UAP may not be so rare and not associated with traumatic delivery/abortion. Some UAP may resolve, and, thus, may not require TAE, at least immediately. (C) 2016 Elsevier Ireland Ltd. All rights reserved.
  • Differential expression of microRNA between human first trimester villous and extravillous trophoblast cells: PCR array-based approach(和訳中)
    Takahashi Hironori, Ohkuchi Akihide, Ishida Yoichi, Takizawa Toshihiro, Matsubara Shigeki
    The Journal of Obstetrics and Gynaecology Research Wiley Publishing Asia Pty Ltd 42 (Suppl.1) 13  1341-8076 2016/10 [Not refereed][Not invited]
  • Letter to "Tardive intermittent massive vaginal bleeding from abnormal blood vessels within cesarean scar: Two more new cases should bring our attention to a new entity": Really, a new entity?(和訳中)
    Matsubara Shigeki, Takahashi Hironori, Usui Rie
    The Journal of Obstetrics and Gynaecology Research Wiley Publishing Asia Pty Ltd 42 (10) 1412  1341-8076 2016/10 [Not refereed][Not invited]
  • Incidence of human papillomavirus contamination of transvaginal probes in Japan and possible contamination prevention strategy(和訳中)
    Kuwata Tomoyuki, Takahashi Hironori, Koibuchi Harumi, Ichizuka Kiyotake, Natori Michiya, Matsubara Shigeki
    Journal of Medical Ultrasonics シュプリンガー・ジャパン(株) 43 (4) 505  1346-4523 2016/10 [Not refereed][Not invited]
  • Antenatal immunoglobulin for prevention of neonatal hemochromatosis(和訳中)
    Okada Noriki, Ihara Yoshiyuki, Urahashi Taizen, Sanada Yukihiro, Yamada Naoya, Hirata Yuta, Tashiro Masahisa, Katano Takumi, Ushijima Kentaro, Otomo Shinya, Takahashi Hironori, Matsubara Shigeki, Mizuta Koichi
    Pediatrics International Wiley Publishing Asia Pty Ltd 58 (10) 1059  1328-8067 2016/10 [Not refereed][Not invited]
  • Differential expression of microRNA between human first trimester villous and extravillous trophoblast cells: PCR array-based approach(和訳中)
    Takahashi Hironori, Ohkuchi Akihide, Ishida Yoichi, Takizawa Toshihiro, Matsubara Shigeki
    The Journal of Obstetrics and Gynaecology Research Wiley Publishing Asia Pty Ltd 42 (Suppl.1) 13  1341-8076 2016/10 [Not refereed][Not invited]
  • Matsubara Shigeki, Takahashi Hironori, Usui Rie
    The Journal of Obstetrics and Gynaecology Research Wiley Publishing Asia Pty Ltd 42 (10) 1412  1341-8076 2016/10 [Not refereed][Not invited]
  • Kuwata Tomoyuki, Takahashi Hironori, Koibuchi Harumi, Ichizuka Kiyotake, Natori Michiya, Matsubara Shigeki
    Journal of Medical Ultrasonics シュプリンガー・ジャパン(株) 43 (4) 505  1346-4523 2016/10 [Not refereed][Not invited]
  • Okada Noriki, Ihara Yoshiyuki, Urahashi Taizen, Sanada Yukihiro, Yamada Naoya, Hirata Yuta, Tashiro Masahisa, Katano Takumi, Ushijima Kentaro, Otomo Shinya, Takahashi Hironori, Matsubara Shigeki, Mizuta Koichi
    Pediatrics International Wiley Publishing Asia Pty Ltd 58 (10) 1059  1328-8067 2016/10 [Not refereed][Not invited]
  • Differential expression of microRNA between human first trimester villous and extravillous trophoblast cells: PCR array-based approach(和訳中)
    Takahashi Hironori, Ohkuchi Akihide, Ishida Yoichi, Takizawa Toshihiro, Matsubara Shigeki
    The Journal of Obstetrics and Gynaecology Research Wiley Publishing Asia Pty Ltd 42 (Suppl.1) 13  1341-8076 2016/10 [Not refereed][Not invited]
  • Shigeki Matsubara, Hironori Takahashi, Rie Usui
    JOURNAL OF OBSTETRICS AND GYNAECOLOGY RESEARCH Wiley Publishing Asia Pty Ltd 42 (10) 1412 - 1413 1341-8076 2016/10 [Not refereed][Not invited]
  • Kuwata Tomoyuki, Takahashi Hironori, Koibuchi Harumi, Ichizuka Kiyotake, Natori Michiya, Matsubara Shigeki
    Journal of Medical Ultrasonics シュプリンガー・ジャパン(株) 43 (4) 505  1346-4523 2016/10 [Not refereed][Not invited]
  • Okada Noriki, Ihara Yoshiyuki, Urahashi Taizen, Sanada Yukihiro, Yamada Naoya, Hirata Yuta, Tashiro Masahisa, Katano Takumi, Ushijima Kentaro, Otomo Shinya, Takahashi Hironori, Matsubara Shigeki, Mizuta Koichi
    Pediatrics International Wiley Publishing Asia Pty Ltd 58 (10) 1059  1328-8067 2016/10 [Not refereed][Not invited]
  • Differential expression of microRNA between human first trimester villous and extravillous trophoblast cells: PCR array-based approach(和訳中)
    Takahashi Hironori, Ohkuchi Akihide, Ishida Yoichi, Takizawa Toshihiro, Matsubara Shigeki
    The Journal of Obstetrics and Gynaecology Research Wiley Publishing Asia Pty Ltd 42 (Suppl.1) 13  1341-8076 2016/10 [Not refereed][Not invited]
  • Letter to "Tardive intermittent massive vaginal bleeding from abnormal blood vessels within cesarean scar: Two more new cases should bring our attention to a new entity": Really, a new entity?(和訳中)
    Matsubara Shigeki, Takahashi Hironori, Usui Rie
    The Journal of Obstetrics and Gynaecology Research Wiley Publishing Asia Pty Ltd 42 (10) 1412  1341-8076 2016/10 [Not refereed][Not invited]
  • Incidence of human papillomavirus contamination of transvaginal probes in Japan and possible contamination prevention strategy(和訳中)
    Kuwata Tomoyuki, Takahashi Hironori, Koibuchi Harumi, Ichizuka Kiyotake, Natori Michiya, Matsubara Shigeki
    Journal of Medical Ultrasonics シュプリンガー・ジャパン(株) 43 (4) 505  1346-4523 2016/10 [Not refereed][Not invited]
  • Antenatal immunoglobulin for prevention of neonatal hemochromatosis(和訳中)
    Okada Noriki, Ihara Yoshiyuki, Urahashi Taizen, Sanada Yukihiro, Yamada Naoya, Hirata Yuta, Tashiro Masahisa, Katano Takumi, Ushijima Kentaro, Otomo Shinya, Takahashi Hironori, Matsubara Shigeki, Mizuta Koichi
    Pediatrics International Wiley Publishing Asia Pty Ltd 58 (10) 1059  1328-8067 2016/10 [Not refereed][Not invited]
  • Baba Y, Takahashi H, Ohkuchi A, Usui R, Matsubara S
    The journal of obstetrics and gynaecology research 42 (11) 1502 - 1508 1341-8076 2016/10 [Refereed][Not invited]
  • Yosuke Baba, Hironori Takahashi, Akihide Ohkuchi, Hirotada Suzuki, Tomoyuki Kuwata, Rie Usui, Miyuki Saruyama, Manabu Ogoyama, Shiho Nagayama, Hiroyasu Nakamura, Atsushi Ugajin, Shigeki Matsubara
    European Journal of Obstetrics Gynecology and Reproductive Biology 205 72 - 78 1872-7654 2016/10 [Refereed][Not invited]
     
    Objectives Uterine artery pseudoaneurysm (UAP) has been considered to occur very rarely after traumatic delivery/abortion, and is usually detected after its rupture, yielding massive bleeding. Our hypothesis is: some UAP may be undetected without massive bleeding and may spontaneously resolve, and, thus, may not require transarterial embolization (TAE). We attempted: (1) to detect both ruptured and non-ruptured UAP, thereby characterizing candidates of spontaneously resolving UAP, and (2) to confirm that UAP is not rare and not always associated with traumatic events. Study design This was a retrospective observational study of 50 women with angiographically confirmed UAP and treated by TAE. Angiograms and medical charts were retrieved to examine the associations among symptoms, ultrasound findings, and extravasation. Gray-scale ultrasound was performed for all women after delivery or abortion as our routine practice. Results UAP occurred in 3–6/1000 deliveries and 40% occurred after non-traumatic deliveries/abortion. While 36% had active vaginal bleeding at admission, 64% did not. While 100% of patients with current active bleeding showed extravasation from the pseudoaneurysmal sac, patients without it showed a varied incidence of extravasation depending on the bleeding pattern/history and ultrasound findings. Interestingly, all patients with current bleeding (−), bleeding history (+), and ultrasound-discernable-intrauterine low echoic mass (−) were devoid of extravasation, suggesting that UAP may show progression to thrombosis and, thus, resolve spontaneously. Conclusions UAP may not be so rare and not associated with traumatic delivery/abortion. Some UAP may resolve, and, thus, may not require TAE, at least immediately.
  • Tomoyuki Kuwata, Hironori Takahashi, Harumi Koibuchi, Kiyotake Ichizuka, Michiya Natori, Shigeki Matsubara
    Journal of medical ultrasonics (2001) 43 (4) 505 - 8 1346-4523 2016/10 [Refereed][Not invited]
     
    PURPOSE: To clarify the present status of human papillomavirus (HPV) contamination of transvaginal probes in Japan and propose a preventive method. METHODS: This study was performed at three institutes: a tertiary center, secondary hospital, and primary facility. To identify contamination rates, probes were disinfected and covered with probe covers and condoms; the cover was changed for each patient. The probes were tested for HPV, and those with HPV detected were analyzed to identify the type of HPV. Next, nurses put on new gloves before covering the probe for each patient, and the probes were similarly tested for HPV. RESULTS: A total of 120 probes were tested, and HPV was detected from a total of five probes, a contamination rate of 4.2 % (5/120). HPV was detected in all three institutes. Importantly, high-risk HPV, i.e., HPV-52, 56, and 59, was detected. After the "glove change strategy" was implemented, HPV was not detected on any of 150 probes tested at any of the three institutions. CONCLUSIONS: In Japan, the HPV contamination rate of vaginal probes in routine practice was 4.2 %. There was no HPV contamination of probes after changing the gloves for cover exchange for each patient. This strategy may prevent HPV probe contamination.
  • Shigeki Matsubara, Hironori Takahashi, Rie Usui
    Journal of Obstetrics and Gynaecology Research 42 (10) 1412 - 1413 1447-0756 2016/10 [Refereed][Not invited]
  • Differential expression of microRNA between human first trimester villous and extravillous trophoblast cells: PCR array-based approach(和訳中)
    Takahashi Hironori, Ohkuchi Akihide, Ishida Yoichi, Takizawa Toshihiro, Matsubara Shigeki
    The Journal of Obstetrics and Gynaecology Research Wiley Publishing Asia Pty Ltd 42 (Suppl.1) 13  1341-8076 2016/10 [Not refereed][Not invited]
  • Matsubara Shigeki, Takahashi Hironori, Usui Rie
    The Journal of Obstetrics and Gynaecology Research Wiley Publishing Asia Pty Ltd 42 (10) 1412  1341-8076 2016/10 [Not refereed][Not invited]
  • Kuwata Tomoyuki, Takahashi Hironori, Koibuchi Harumi, Ichizuka Kiyotake, Natori Michiya, Matsubara Shigeki
    Journal of Medical Ultrasonics シュプリンガー・ジャパン(株) 43 (4) 505  1346-4523 2016/10 [Not refereed][Not invited]
  • Okada Noriki, Ihara Yoshiyuki, Urahashi Taizen, Sanada Yukihiro, Yamada Naoya, Hirata Yuta, Tashiro Masahisa, Katano Takumi, Ushijima Kentaro, Otomo Shinya, Takahashi Hironori, Matsubara Shigeki, Mizuta Koichi
    Pediatrics International Wiley Publishing Asia Pty Ltd 58 (10) 1059  1328-8067 2016/10 [Not refereed][Not invited]
  • Shigeki Matsubara, Hironori Takahashi, Yosuke Baba
    ARCHIVES OF GYNECOLOGY AND OBSTETRICS 294 (3) 669 - 670 0932-0067 2016/09 [Refereed][Not invited]
  • Shigeki Matsubara, Hironori Takahashi, Yosuke Baba
    JOURNAL OF OBSTETRICS AND GYNAECOLOGY RESEARCH 42 (9) 1203 - 1204 1341-8076 2016/09 [Refereed][Not invited]
  • Okada N, Ihara Y, Urahashi T, Sanada Y, Yamada N, Hirata Y, Tashiro M, Katano T, Ushijima K, Otomo S, Takahashi H, Matsubara S, Mizuta K
    Pediatrics international : official journal of the Japan Pediatric Society 58 (10) 1059 - 1061 1328-8067 2016/08 [Refereed][Not invited]
  • Shigeki Matsubara, Hironori Takahashi, Yuji Takei, Alan K. Lefor
    BJOG-AN INTERNATIONAL JOURNAL OF OBSTETRICS AND GYNAECOLOGY 123 (8) 1404 - 1405 1470-0328 2016/07 [Refereed][Not invited]
  • Yosuke Baba, Akihide Ohkuchi, Rie Usui, Hironori Takahashi, Shigeki Matsubara
    JOURNAL OF OBSTETRICS AND GYNAECOLOGY RESEARCH 42 (7) 784 - 788 1341-8076 2016/07 [Refereed][Not invited]
     
    AimIn hypertensive pregnant women, the protein-to-creatinine (P/C) ratio is well correlated with 24-h proteinuria and a P/C ratio of 0.27 (g/gCr) is used to reflect significant proteinuria (>0.3 g/day). The aim of this study was to obtain data on normotensive pregnant women, which have so far been lacking. MethodsThe study population consisted of 74 pregnant women who met the following criteria: (i) 22 gestational weeks; (ii) a positive result (1+) on dipstick test; (iii) a positive result (>0.27) for P/C ratio; and (iv) 24-h urine test performed within 2 days of the P/C ratio. The correlation between the P/C ratio and 24-h proteinuria, the incidence rates of significant proteinuria according to P/C ratios, and appropriate threshold of the P/C ratio to rule in significant proteinuria were determined using the appropriate statistical methods. ResultsThe P/C ratio was moderately correlated with the 24-h proteinuria, with a correlation coefficient of 0.64 (95% confidence interval, 0.487-0.76). The area under the receiver-operator curve was 0.76 (95% confidence interval, 0.66-0.87); however, no clear shoulder was identifiable. The incidence rates of significant proteinuria according to P/C ratios of 0.27-0.49, 0.50-0.74, 0.75-0.99, and >1 were 41, 66, 100, and 100%, respectively, indicating that all normotensive pregnant women with a P/C ratio > 0.75 had significant proteinuria. ConclusionNormotensive pregnant women showed a significant correlation between the P/C ratio and 24-h urine protein level. All normotensive pregnant women with a P/C ratio > 0.75 had significant proteinuria, suggesting that a P/C ratio > 0.75 may be the rule-in' threshold of significant proteinuria in this population.
  • Hironori Takahashi, Kenji Horie, Satoshi Hayashi, Shigeki Matsubara
    ARCHIVES OF GYNECOLOGY AND OBSTETRICS 294 (1) 213 - 214 0932-0067 2016/07 [Refereed][Not invited]
  • Shigeki Matsubara, Hironori Takahashi, Yoshio Misawa, Alan K. Lefor
    JOURNAL OF OBSTETRICS AND GYNAECOLOGY RESEARCH 42 (6) 752 - 752 1341-8076 2016/06 [Refereed][Not invited]
  • Shigeki Matsubara, Yosuke Baba, Hironori Takahashi
    ARCHIVES OF GYNECOLOGY AND OBSTETRICS 293 (6) 1363 - 1364 0932-0067 2016/06 [Refereed][Not invited]
  • Shigeki Matsubara, Hironori Takahashi, Manabu Ogoyama, Akihide Ohkuchi, Hiroyasu Nakamura, Yoshio Misawa
    ARCHIVES OF GYNECOLOGY AND OBSTETRICS 293 (6) 1361 - 1362 0932-0067 2016/06 [Refereed][Not invited]
  • Hironori Takahashi, Yosuke Baba, Rie Usui, Akihide Ohkuchi, Shigeyoshi Kijima, Shigeki Matsubara
    JOURNAL OF OBSTETRICS AND GYNAECOLOGY RESEARCH 42 (6) 730 - 733 1341-8076 2016/06 [Refereed][Not invited]
     
    Post-delivery/-abortion uterine artery pseudoaneurysm (UAP) sometimes causes life-threatening bleeding, requiring transarterial embolization (TAE). It is unclear whether some UAP resolve spontaneously. In three patients, UAP resolved spontaneously without TAE. Case 1 was after vacuum delivery with slight bleeding: at day 5 post-partum, a yin-yang sign on Color Doppler and an enhanced intrauterine sac-like structure were observed, leading to the diagnosis of UAP, which disappeared at 4 weeks post-partum. Case 2 was after vacuum delivery with manual placental removal and was asymptomatic: a hypoechoic intrauterine mass with a yin-yang sign were observed during a post-partum routine check-up and the intrauterine flow disappeared at 4 weeks post-partum. Case 3 was after dilatation and curettage in the first trimester with slight bleeding: UAP was detected at 4 weeks post-abortion, which disappeared at 6 weeks post-abortion. All three cases had a small UAP (diameter: 10-15 mm) and low-level or no symptoms. Some UAP may resolve spontaneously and, thus, may not require TAE.
  • 高橋 宏典
    ペリネイタルケア (株)メディカ出版 35 (5) 451  0910-8718 2016/05 [Not refereed][Not invited]
  • 高橋 宏典
    ペリネイタルケア (株)メディカ出版 35 (5) 451  0910-8718 2016/05 [Not refereed][Not invited]
  • 高橋 宏典
    ペリネイタルケア (株)メディカ出版 35 (5) 451  0910-8718 2016/05 [Not refereed][Not invited]
  • 高橋 宏典
    ペリネイタルケア (株)メディカ出版 35 (5) 451  0910-8718 2016/05 [Not refereed][Not invited]
  • 高橋 宏典
    ペリネイタルケア (株)メディカ出版 35 (5) 451  0910-8718 2016/05 [Not refereed][Not invited]
  • 高橋 宏典
    ペリネイタルケア (株)メディカ出版 35 (5) 451  0910-8718 2016/05 [Not refereed][Not invited]
  • 高橋 宏典
    ペリネイタルケア (株)メディカ出版 35 (5) 451  0910-8718 2016/05 [Not refereed][Not invited]
  • 高橋 宏典
    ペリネイタルケア (株)メディカ出版 35 (5) 451  0910-8718 2016/05 [Not refereed][Not invited]
  • 高橋 宏典
    ペリネイタルケア (株)メディカ出版 35 (5) 451  0910-8718 2016/05 [Not refereed][Not invited]
  • 高橋 宏典
    ペリネイタルケア (株)メディカ出版 35 (5) 451  0910-8718 2016/05 [Not refereed][Not invited]
  • 高橋 宏典
    ペリネイタルケア (株)メディカ出版 35 (5) 451  0910-8718 2016/05 [Not refereed][Not invited]
  • 高橋 宏典
    ペリネイタルケア (株)メディカ出版 35 (5) 451  0910-8718 2016/05 [Not refereed][Not invited]
  • 高橋 宏典
    ペリネイタルケア (株)メディカ出版 35 (5) 451  0910-8718 2016/05 [Not refereed][Not invited]
  • 高橋 宏典
    ペリネイタルケア (株)メディカ出版 35 (5) 451  0910-8718 2016/05 [Not refereed][Not invited]
  • 高橋 宏典
    ペリネイタルケア (株)メディカ出版 35 (5) 451  0910-8718 2016/05 [Not refereed][Not invited]
  • 高橋 宏典
    ペリネイタルケア (株)メディカ出版 35 (5) 451  0910-8718 2016/05 [Not refereed][Not invited]
  • 高橋 宏典
    ペリネイタルケア (株)メディカ出版 35 (5) 451  0910-8718 2016/05 [Not refereed][Not invited]
  • 高橋 宏典
    ペリネイタルケア (株)メディカ出版 35 (5) 451  0910-8718 2016/05 [Not refereed][Not invited]
  • 高橋 宏典
    ペリネイタルケア (株)メディカ出版 35 (5) 451  0910-8718 2016/05 [Not refereed][Not invited]
  • 高橋 宏典
    ペリネイタルケア (株)メディカ出版 35 (5) 451  0910-8718 2016/05 [Not refereed][Not invited]
  • 高橋 宏典
    ペリネイタルケア (株)メディカ出版 35 (5) 451  0910-8718 2016/05 [Not refereed][Not invited]
  • 高橋 宏典
    ペリネイタルケア (株)メディカ出版 35 (5) 451  0910-8718 2016/05 [Not refereed][Not invited]
  • H. Takahashi, A. Ohkuchi, T. Kuwata, R. Usui, S. Takahashi, S. Matsubara
    JOURNAL OF OBSTETRICS AND GYNAECOLOGY 36 (3) 340 - 344 0144-3615 2016/04 [Refereed][Not invited]
     
    To characterise congenital mesoblastic nephroma (CMN), with special emphasis on polyhydramnios and the neonatal prognosis, we summarise 31 CMN patients (30 reported patients and the present patient). CMN was detected at a median of 30 weeks' gestation, and infants were delivered at a median of 34 weeks' gestation. Of 27 patients with available data, 19 (70%) had polyhydramnios, of which 8 required amnio- drainage. Women with amnio-drainage gave birth significantly earlier (30.4 weeks' gestation) than those without polyhydramnios (36.7 weeks' gestation). Thus, CMN was frequently associated with polyhydramnios and this polyhydramnios was associated with a significant increase in the risk of preterm birth. Of 20 patients with available data, the affected-side kidney was 'compressed' in 16 and 'replaced' in 4: polyhydramnios was present in a half vs 100%, respectively, suggesting that a 'replaced' kidney may suggest a more aggressive tumour and may be associated with a poorer prognosis. Univariate analysis showed that early gestational week at diagnosis was the only feature significantly associated with poor prognosis. Thus, polyhydramnios, 'replaced' kidney and early gestational week at diagnosis, may indicate poor prognosis, to which obstetricians should pay attention.
  • Shigeki Matsubara, Tomoyuki Kuwata, Hironori Takahashi, Hirotada Suzuki
    JOURNAL OF MATERNAL-FETAL & NEONATAL MEDICINE 29 (7) 1139 - 1140 1476-7058 2016/04 [Refereed][Not invited]
  • 横山 美樹, 廣瀬 典子, 鈴木 寛正, 高橋 宏典, 馬場 洋介, 薄井 里英, 大口 昭英, 松原 茂樹
    栃木県産婦人科医報 栃木県産科婦人科学会 42 53  2016/03 [Not refereed][Not invited]
     
    新生児同種免疫性血小板減少症(Neonatal alloimmune thrombocytopenia:NAIT)とは、免疫学的機序により起こる児の一過性血小板減少症であり、同胞罹患率が高い。母親に患児の血小板と反応する抗血小板抗体が証明されることが診断基準の一つであるが、原因抗体が明らかでない同胞発症症例を経験した。臨床経過からNAITが否定できない場合には、原因抗体が不明であっても次の妊娠分娩の際にNAITに準じた慎重な管理が必要である。(著者抄録)
  • 佐野 実穂, 鈴木 寛正, 薄井 里英, 桑田 円, 横山 瑞浩, 堀江 健司, 高橋 宏典, 馬場 洋介, 大口 昭英, 松原 茂樹
    栃木県母性衛生学会雑誌: とちぼ 栃木県母性衛生学会 (42) 13  2016/03 [Not refereed][Not invited]
     
    40歳(2経妊0経産)。妊娠19週4日に出血と腹部膨満感を主訴に来院し、切迫流産の診断で入院となった。塩酸リトドリンの経静脈投与を66μg/分から開始し、炎症所見が軽快した後、21週0日に緊急マクドナルド頸管縫縮術を行った。その後、子宮収縮や頸管所見に応じてリトドリンを200μg/分まで徐々に増量した。母体の心拍数はリトドリン投与前が80bpm台、投与後が90〜110bpmであった。リトドリン投与55日目、起床時に突然の強い動悸を訴えた。脈拍は150〜170bpm、血圧は118/56mmHg、SpO2は97%、12誘導心電図は心拍数160bpm、R-R間隔は不整でP波を認めず、心房細動と診断した。心房細動の原因を明らかにするため、原因となりうる「心疾患」「電解質異常」「甲状腺機能亢進症」「薬剤」について鑑別診断を行った結果、「心疾患」「電解質異常」「甲状腺機能亢進症」は否定的であり、投与中
  • 横山 美樹, 廣瀬 典子, 鈴木 寛正, 高橋 宏典, 馬場 洋介, 薄井 里英, 大口 昭英, 松原 茂樹
    栃木県産婦人科医報 栃木県産科婦人科学会 42 53  2016/03 [Not refereed][Not invited]
     
    新生児同種免疫性血小板減少症(Neonatal alloimmune thrombocytopenia:NAIT)とは、免疫学的機序により起こる児の一過性血小板減少症であり、同胞罹患率が高い。母親に患児の血小板と反応する抗血小板抗体が証明されることが診断基準の一つであるが、原因抗体が明らかでない同胞発症症例を経験した。臨床経過からNAITが否定できない場合には、原因抗体が不明であっても次の妊娠分娩の際にNAITに準じた慎重な管理が必要である。(著者抄録)
  • 佐野 実穂, 鈴木 寛正, 薄井 里英, 桑田 円, 横山 瑞浩, 堀江 健司, 高橋 宏典, 馬場 洋介, 大口 昭英, 松原 茂樹
    栃木県母性衛生学会雑誌: とちぼ 栃木県母性衛生学会 (42) 13  2016/03 [Not refereed][Not invited]
     
    40歳(2経妊0経産)。妊娠19週4日に出血と腹部膨満感を主訴に来院し、切迫流産の診断で入院となった。塩酸リトドリンの経静脈投与を66μg/分から開始し、炎症所見が軽快した後、21週0日に緊急マクドナルド頸管縫縮術を行った。その後、子宮収縮や頸管所見に応じてリトドリンを200μg/分まで徐々に増量した。母体の心拍数はリトドリン投与前が80bpm台、投与後が90〜110bpmであった。リトドリン投与55日目、起床時に突然の強い動悸を訴えた。脈拍は150〜170bpm、血圧は118/56mmHg、SpO2は97%、12誘導心電図は心拍数160bpm、R-R間隔は不整でP波を認めず、心房細動と診断した。心房細動の原因を明らかにするため、原因となりうる「心疾患」「電解質異常」「甲状腺機能亢進症」「薬剤」について鑑別診断を行った結果、「心疾患」「電解質異常」「甲状腺機能亢進症」は否定的であり、投与中
  • 横山 美樹, 廣瀬 典子, 鈴木 寛正, 高橋 宏典, 馬場 洋介, 薄井 里英, 大口 昭英, 松原 茂樹
    栃木県産婦人科医報 栃木県産科婦人科学会 42 53  2016/03 [Not refereed][Not invited]
     
    新生児同種免疫性血小板減少症(Neonatal alloimmune thrombocytopenia:NAIT)とは、免疫学的機序により起こる児の一過性血小板減少症であり、同胞罹患率が高い。母親に患児の血小板と反応する抗血小板抗体が証明されることが診断基準の一つであるが、原因抗体が明らかでない同胞発症症例を経験した。臨床経過からNAITが否定できない場合には、原因抗体が不明であっても次の妊娠分娩の際にNAITに準じた慎重な管理が必要である。(著者抄録)
  • 佐野 実穂, 鈴木 寛正, 薄井 里英, 桑田 円, 横山 瑞浩, 堀江 健司, 高橋 宏典, 馬場 洋介, 大口 昭英, 松原 茂樹
    栃木県母性衛生学会雑誌: とちぼ 栃木県母性衛生学会 (42) 13  2016/03 [Not refereed][Not invited]
     
    40歳(2経妊0経産)。妊娠19週4日に出血と腹部膨満感を主訴に来院し、切迫流産の診断で入院となった。塩酸リトドリンの経静脈投与を66μg/分から開始し、炎症所見が軽快した後、21週0日に緊急マクドナルド頸管縫縮術を行った。その後、子宮収縮や頸管所見に応じてリトドリンを200μg/分まで徐々に増量した。母体の心拍数はリトドリン投与前が80bpm台、投与後が90〜110bpmであった。リトドリン投与55日目、起床時に突然の強い動悸を訴えた。脈拍は150〜170bpm、血圧は118/56mmHg、SpO2は97%、12誘導心電図は心拍数160bpm、R-R間隔は不整でP波を認めず、心房細動と診断した。心房細動の原因を明らかにするため、原因となりうる「心疾患」「電解質異常」「甲状腺機能亢進症」「薬剤」について鑑別診断を行った結果、「心疾患」「電解質異常」「甲状腺機能亢進症」は否定的であり、投与中
  • 横山 美樹, 廣瀬 典子, 鈴木 寛正, 高橋 宏典, 馬場 洋介, 薄井 里英, 大口 昭英, 松原 茂樹
    栃木県産婦人科医報 栃木県産科婦人科学会 42 53  2016/03 [Not refereed][Not invited]
     
    新生児同種免疫性血小板減少症(Neonatal alloimmune thrombocytopenia:NAIT)とは、免疫学的機序により起こる児の一過性血小板減少症であり、同胞罹患率が高い。母親に患児の血小板と反応する抗血小板抗体が証明されることが診断基準の一つであるが、原因抗体が明らかでない同胞発症症例を経験した。臨床経過からNAITが否定できない場合には、原因抗体が不明であっても次の妊娠分娩の際にNAITに準じた慎重な管理が必要である。(著者抄録)
  • 佐野 実穂, 鈴木 寛正, 薄井 里英, 桑田 円, 横山 瑞浩, 堀江 健司, 高橋 宏典, 馬場 洋介, 大口 昭英, 松原 茂樹
    栃木県母性衛生学会雑誌: とちぼ 栃木県母性衛生学会 (42) 13  2016/03 [Not refereed][Not invited]
     
    40歳(2経妊0経産)。妊娠19週4日に出血と腹部膨満感を主訴に来院し、切迫流産の診断で入院となった。塩酸リトドリンの経静脈投与を66μg/分から開始し、炎症所見が軽快した後、21週0日に緊急マクドナルド頸管縫縮術を行った。その後、子宮収縮や頸管所見に応じてリトドリンを200μg/分まで徐々に増量した。母体の心拍数はリトドリン投与前が80bpm台、投与後が90〜110bpmであった。リトドリン投与55日目、起床時に突然の強い動悸を訴えた。脈拍は150〜170bpm、血圧は118/56mmHg、SpO2は97%、12誘導心電図は心拍数160bpm、R-R間隔は不整でP波を認めず、心房細動と診断した。心房細動の原因を明らかにするため、原因となりうる「心疾患」「電解質異常」「甲状腺機能亢進症」「薬剤」について鑑別診断を行った結果、「心疾患」「電解質異常」「甲状腺機能亢進症」は否定的であり、投与中
  • 横山 美樹, 廣瀬 典子, 鈴木 寛正, 高橋 宏典, 馬場 洋介, 薄井 里英, 大口 昭英, 松原 茂樹
    栃木県産婦人科医報 栃木県産科婦人科学会 42 53  2016/03 [Not refereed][Not invited]
     
    新生児同種免疫性血小板減少症(Neonatal alloimmune thrombocytopenia:NAIT)とは、免疫学的機序により起こる児の一過性血小板減少症であり、同胞罹患率が高い。母親に患児の血小板と反応する抗血小板抗体が証明されることが診断基準の一つであるが、原因抗体が明らかでない同胞発症症例を経験した。臨床経過からNAITが否定できない場合には、原因抗体が不明であっても次の妊娠分娩の際にNAITに準じた慎重な管理が必要である。(著者抄録)
  • 佐野 実穂, 鈴木 寛正, 薄井 里英, 桑田 円, 横山 瑞浩, 堀江 健司, 高橋 宏典, 馬場 洋介, 大口 昭英, 松原 茂樹
    栃木県母性衛生学会雑誌: とちぼ 栃木県母性衛生学会 (42) 13  2016/03 [Not refereed][Not invited]
     
    40歳(2経妊0経産)。妊娠19週4日に出血と腹部膨満感を主訴に来院し、切迫流産の診断で入院となった。塩酸リトドリンの経静脈投与を66μg/分から開始し、炎症所見が軽快した後、21週0日に緊急マクドナルド頸管縫縮術を行った。その後、子宮収縮や頸管所見に応じてリトドリンを200μg/分まで徐々に増量した。母体の心拍数はリトドリン投与前が80bpm台、投与後が90〜110bpmであった。リトドリン投与55日目、起床時に突然の強い動悸を訴えた。脈拍は150〜170bpm、血圧は118/56mmHg、SpO2は97%、12誘導心電図は心拍数160bpm、R-R間隔は不整でP波を認めず、心房細動と診断した。心房細動の原因を明らかにするため、原因となりうる「心疾患」「電解質異常」「甲状腺機能亢進症」「薬剤」について鑑別診断を行った結果、「心疾患」「電解質異常」「甲状腺機能亢進症」は否定的であり、投与中
  • 横山 美樹, 廣瀬 典子, 鈴木 寛正, 高橋 宏典, 馬場 洋介, 薄井 里英, 大口 昭英, 松原 茂樹
    栃木県産婦人科医報 栃木県産科婦人科学会 42 53  2016/03 [Not refereed][Not invited]
     
    新生児同種免疫性血小板減少症(Neonatal alloimmune thrombocytopenia:NAIT)とは、免疫学的機序により起こる児の一過性血小板減少症であり、同胞罹患率が高い。母親に患児の血小板と反応する抗血小板抗体が証明されることが診断基準の一つであるが、原因抗体が明らかでない同胞発症症例を経験した。臨床経過からNAITが否定できない場合には、原因抗体が不明であっても次の妊娠分娩の際にNAITに準じた慎重な管理が必要である。(著者抄録)
  • 佐野 実穂, 鈴木 寛正, 薄井 里英, 桑田 円, 横山 瑞浩, 堀江 健司, 高橋 宏典, 馬場 洋介, 大口 昭英, 松原 茂樹
    栃木県母性衛生学会雑誌: とちぼ 栃木県母性衛生学会 (42) 13  2016/03 [Not refereed][Not invited]
     
    40歳(2経妊0経産)。妊娠19週4日に出血と腹部膨満感を主訴に来院し、切迫流産の診断で入院となった。塩酸リトドリンの経静脈投与を66μg/分から開始し、炎症所見が軽快した後、21週0日に緊急マクドナルド頸管縫縮術を行った。その後、子宮収縮や頸管所見に応じてリトドリンを200μg/分まで徐々に増量した。母体の心拍数はリトドリン投与前が80bpm台、投与後が90〜110bpmであった。リトドリン投与55日目、起床時に突然の強い動悸を訴えた。脈拍は150〜170bpm、血圧は118/56mmHg、SpO2は97%、12誘導心電図は心拍数160bpm、R-R間隔は不整でP波を認めず、心房細動と診断した。心房細動の原因を明らかにするため、原因となりうる「心疾患」「電解質異常」「甲状腺機能亢進症」「薬剤」について鑑別診断を行った結果、「心疾患」「電解質異常」「甲状腺機能亢進症」は否定的であり、投与中
  • 横山 美樹, 廣瀬 典子, 鈴木 寛正, 高橋 宏典, 馬場 洋介, 薄井 里英, 大口 昭英, 松原 茂樹
    栃木県産婦人科医報 栃木県産科婦人科学会 42 53  2016/03 [Not refereed][Not invited]
     
    新生児同種免疫性血小板減少症(Neonatal alloimmune thrombocytopenia:NAIT)とは、免疫学的機序により起こる児の一過性血小板減少症であり、同胞罹患率が高い。母親に患児の血小板と反応する抗血小板抗体が証明されることが診断基準の一つであるが、原因抗体が明らかでない同胞発症症例を経験した。臨床経過からNAITが否定できない場合には、原因抗体が不明であっても次の妊娠分娩の際にNAITに準じた慎重な管理が必要である。(著者抄録)
  • 佐野 実穂, 鈴木 寛正, 薄井 里英, 桑田 円, 横山 瑞浩, 堀江 健司, 高橋 宏典, 馬場 洋介, 大口 昭英, 松原 茂樹
    栃木県母性衛生学会雑誌: とちぼ 栃木県母性衛生学会 (42) 13  2016/03 [Not refereed][Not invited]
     
    40歳(2経妊0経産)。妊娠19週4日に出血と腹部膨満感を主訴に来院し、切迫流産の診断で入院となった。塩酸リトドリンの経静脈投与を66μg/分から開始し、炎症所見が軽快した後、21週0日に緊急マクドナルド頸管縫縮術を行った。その後、子宮収縮や頸管所見に応じてリトドリンを200μg/分まで徐々に増量した。母体の心拍数はリトドリン投与前が80bpm台、投与後が90〜110bpmであった。リトドリン投与55日目、起床時に突然の強い動悸を訴えた。脈拍は150〜170bpm、血圧は118/56mmHg、SpO2は97%、12誘導心電図は心拍数160bpm、R-R間隔は不整でP波を認めず、心房細動と診断した。心房細動の原因を明らかにするため、原因となりうる「心疾患」「電解質異常」「甲状腺機能亢進症」「薬剤」について鑑別診断を行った結果、「心疾患」「電解質異常」「甲状腺機能亢進症」は否定的であり、投与中
  • 横山 美樹, 廣瀬 典子, 鈴木 寛正, 高橋 宏典, 馬場 洋介, 薄井 里英, 大口 昭英, 松原 茂樹
    栃木県産婦人科医報 栃木県産科婦人科学会 42 53  2016/03 [Not refereed][Not invited]
     
    新生児同種免疫性血小板減少症(Neonatal alloimmune thrombocytopenia:NAIT)とは、免疫学的機序により起こる児の一過性血小板減少症であり、同胞罹患率が高い。母親に患児の血小板と反応する抗血小板抗体が証明されることが診断基準の一つであるが、原因抗体が明らかでない同胞発症症例を経験した。臨床経過からNAITが否定できない場合には、原因抗体が不明であっても次の妊娠分娩の際にNAITに準じた慎重な管理が必要である。(著者抄録)
  • 佐野 実穂, 鈴木 寛正, 薄井 里英, 桑田 円, 横山 瑞浩, 堀江 健司, 高橋 宏典, 馬場 洋介, 大口 昭英, 松原 茂樹
    栃木県母性衛生学会雑誌: とちぼ 栃木県母性衛生学会 (42) 13  2016/03 [Not refereed][Not invited]
     
    40歳(2経妊0経産)。妊娠19週4日に出血と腹部膨満感を主訴に来院し、切迫流産の診断で入院となった。塩酸リトドリンの経静脈投与を66μg/分から開始し、炎症所見が軽快した後、21週0日に緊急マクドナルド頸管縫縮術を行った。その後、子宮収縮や頸管所見に応じてリトドリンを200μg/分まで徐々に増量した。母体の心拍数はリトドリン投与前が80bpm台、投与後が90〜110bpmであった。リトドリン投与55日目、起床時に突然の強い動悸を訴えた。脈拍は150〜170bpm、血圧は118/56mmHg、SpO2は97%、12誘導心電図は心拍数160bpm、R-R間隔は不整でP波を認めず、心房細動と診断した。心房細動の原因を明らかにするため、原因となりうる「心疾患」「電解質異常」「甲状腺機能亢進症」「薬剤」について鑑別診断を行った結果、「心疾患」「電解質異常」「甲状腺機能亢進症」は否定的であり、投与中
  • 横山 美樹, 廣瀬 典子, 鈴木 寛正, 高橋 宏典, 馬場 洋介, 薄井 里英, 大口 昭英, 松原 茂樹
    栃木県産婦人科医報 栃木県産科婦人科学会 42 53  2016/03 [Not refereed][Not invited]
     
    新生児同種免疫性血小板減少症(Neonatal alloimmune thrombocytopenia:NAIT)とは、免疫学的機序により起こる児の一過性血小板減少症であり、同胞罹患率が高い。母親に患児の血小板と反応する抗血小板抗体が証明されることが診断基準の一つであるが、原因抗体が明らかでない同胞発症症例を経験した。臨床経過からNAITが否定できない場合には、原因抗体が不明であっても次の妊娠分娩の際にNAITに準じた慎重な管理が必要である。(著者抄録)
  • 佐野 実穂, 鈴木 寛正, 薄井 里英, 桑田 円, 横山 瑞浩, 堀江 健司, 高橋 宏典, 馬場 洋介, 大口 昭英, 松原 茂樹
    栃木県母性衛生学会雑誌: とちぼ 栃木県母性衛生学会 (42) 13  2016/03 [Not refereed][Not invited]
     
    40歳(2経妊0経産)。妊娠19週4日に出血と腹部膨満感を主訴に来院し、切迫流産の診断で入院となった。塩酸リトドリンの経静脈投与を66μg/分から開始し、炎症所見が軽快した後、21週0日に緊急マクドナルド頸管縫縮術を行った。その後、子宮収縮や頸管所見に応じてリトドリンを200μg/分まで徐々に増量した。母体の心拍数はリトドリン投与前が80bpm台、投与後が90〜110bpmであった。リトドリン投与55日目、起床時に突然の強い動悸を訴えた。脈拍は150〜170bpm、血圧は118/56mmHg、SpO2は97%、12誘導心電図は心拍数160bpm、R-R間隔は不整でP波を認めず、心房細動と診断した。心房細動の原因を明らかにするため、原因となりうる「心疾患」「電解質異常」「甲状腺機能亢進症」「薬剤」について鑑別診断を行った結果、「心疾患」「電解質異常」「甲状腺機能亢進症」は否定的であり、投与中
  • 横山 美樹, 廣瀬 典子, 鈴木 寛正, 高橋 宏典, 馬場 洋介, 薄井 里英, 大口 昭英, 松原 茂樹
    栃木県産婦人科医報 栃木県産科婦人科学会 42 53  2016/03 [Not refereed][Not invited]
     
    新生児同種免疫性血小板減少症(Neonatal alloimmune thrombocytopenia:NAIT)とは、免疫学的機序により起こる児の一過性血小板減少症であり、同胞罹患率が高い。母親に患児の血小板と反応する抗血小板抗体が証明されることが診断基準の一つであるが、原因抗体が明らかでない同胞発症症例を経験した。臨床経過からNAITが否定できない場合には、原因抗体が不明であっても次の妊娠分娩の際にNAITに準じた慎重な管理が必要である。(著者抄録)
  • 佐野 実穂, 鈴木 寛正, 薄井 里英, 桑田 円, 横山 瑞浩, 堀江 健司, 高橋 宏典, 馬場 洋介, 大口 昭英, 松原 茂樹
    栃木県母性衛生学会雑誌: とちぼ 栃木県母性衛生学会 (42) 13  2016/03 [Not refereed][Not invited]
     
    40歳(2経妊0経産)。妊娠19週4日に出血と腹部膨満感を主訴に来院し、切迫流産の診断で入院となった。塩酸リトドリンの経静脈投与を66μg/分から開始し、炎症所見が軽快した後、21週0日に緊急マクドナルド頸管縫縮術を行った。その後、子宮収縮や頸管所見に応じてリトドリンを200μg/分まで徐々に増量した。母体の心拍数はリトドリン投与前が80bpm台、投与後が90〜110bpmであった。リトドリン投与55日目、起床時に突然の強い動悸を訴えた。脈拍は150〜170bpm、血圧は118/56mmHg、SpO2は97%、12誘導心電図は心拍数160bpm、R-R間隔は不整でP波を認めず、心房細動と診断した。心房細動の原因を明らかにするため、原因となりうる「心疾患」「電解質異常」「甲状腺機能亢進症」「薬剤」について鑑別診断を行った結果、「心疾患」「電解質異常」「甲状腺機能亢進症」は否定的であり、投与中
  • 横山 美樹, 廣瀬 典子, 鈴木 寛正, 高橋 宏典, 馬場 洋介, 薄井 里英, 大口 昭英, 松原 茂樹
    栃木県産婦人科医報 栃木県産科婦人科学会 42 53  2016/03 [Not refereed][Not invited]
     
    新生児同種免疫性血小板減少症(Neonatal alloimmune thrombocytopenia:NAIT)とは、免疫学的機序により起こる児の一過性血小板減少症であり、同胞罹患率が高い。母親に患児の血小板と反応する抗血小板抗体が証明されることが診断基準の一つであるが、原因抗体が明らかでない同胞発症症例を経験した。臨床経過からNAITが否定できない場合には、原因抗体が不明であっても次の妊娠分娩の際にNAITに準じた慎重な管理が必要である。(著者抄録)
  • 佐野 実穂, 鈴木 寛正, 薄井 里英, 桑田 円, 横山 瑞浩, 堀江 健司, 高橋 宏典, 馬場 洋介, 大口 昭英, 松原 茂樹
    栃木県母性衛生学会雑誌: とちぼ 栃木県母性衛生学会 (42) 13  2016/03 [Not refereed][Not invited]
     
    40歳(2経妊0経産)。妊娠19週4日に出血と腹部膨満感を主訴に来院し、切迫流産の診断で入院となった。塩酸リトドリンの経静脈投与を66μg/分から開始し、炎症所見が軽快した後、21週0日に緊急マクドナルド頸管縫縮術を行った。その後、子宮収縮や頸管所見に応じてリトドリンを200μg/分まで徐々に増量した。母体の心拍数はリトドリン投与前が80bpm台、投与後が90〜110bpmであった。リトドリン投与55日目、起床時に突然の強い動悸を訴えた。脈拍は150〜170bpm、血圧は118/56mmHg、SpO2は97%、12誘導心電図は心拍数160bpm、R-R間隔は不整でP波を認めず、心房細動と診断した。心房細動の原因を明らかにするため、原因となりうる「心疾患」「電解質異常」「甲状腺機能亢進症」「薬剤」について鑑別診断を行った結果、「心疾患」「電解質異常」「甲状腺機能亢進症」は否定的であり、投与中
  • 横山 美樹, 廣瀬 典子, 鈴木 寛正, 高橋 宏典, 馬場 洋介, 薄井 里英, 大口 昭英, 松原 茂樹
    栃木県産婦人科医報 栃木県産科婦人科学会 42 53  2016/03 [Not refereed][Not invited]
     
    新生児同種免疫性血小板減少症(Neonatal alloimmune thrombocytopenia:NAIT)とは、免疫学的機序により起こる児の一過性血小板減少症であり、同胞罹患率が高い。母親に患児の血小板と反応する抗血小板抗体が証明されることが診断基準の一つであるが、原因抗体が明らかでない同胞発症症例を経験した。臨床経過からNAITが否定できない場合には、原因抗体が不明であっても次の妊娠分娩の際にNAITに準じた慎重な管理が必要である。(著者抄録)
  • 佐野 実穂, 鈴木 寛正, 薄井 里英, 桑田 円, 横山 瑞浩, 堀江 健司, 高橋 宏典, 馬場 洋介, 大口 昭英, 松原 茂樹
    栃木県母性衛生学会雑誌: とちぼ 栃木県母性衛生学会 (42) 13  2016/03 [Not refereed][Not invited]
     
    40歳(2経妊0経産)。妊娠19週4日に出血と腹部膨満感を主訴に来院し、切迫流産の診断で入院となった。塩酸リトドリンの経静脈投与を66μg/分から開始し、炎症所見が軽快した後、21週0日に緊急マクドナルド頸管縫縮術を行った。その後、子宮収縮や頸管所見に応じてリトドリンを200μg/分まで徐々に増量した。母体の心拍数はリトドリン投与前が80bpm台、投与後が90〜110bpmであった。リトドリン投与55日目、起床時に突然の強い動悸を訴えた。脈拍は150〜170bpm、血圧は118/56mmHg、SpO2は97%、12誘導心電図は心拍数160bpm、R-R間隔は不整でP波を認めず、心房細動と診断した。心房細動の原因を明らかにするため、原因となりうる「心疾患」「電解質異常」「甲状腺機能亢進症」「薬剤」について鑑別診断を行った結果、「心疾患」「電解質異常」「甲状腺機能亢進症」は否定的であり、投与中
  • 横山 美樹, 廣瀬 典子, 鈴木 寛正, 高橋 宏典, 馬場 洋介, 薄井 里英, 大口 昭英, 松原 茂樹
    栃木県産婦人科医報 栃木県産科婦人科学会 42 53  2016/03 [Not refereed][Not invited]
     
    新生児同種免疫性血小板減少症(Neonatal alloimmune thrombocytopenia:NAIT)とは、免疫学的機序により起こる児の一過性血小板減少症であり、同胞罹患率が高い。母親に患児の血小板と反応する抗血小板抗体が証明されることが診断基準の一つであるが、原因抗体が明らかでない同胞発症症例を経験した。臨床経過からNAITが否定できない場合には、原因抗体が不明であっても次の妊娠分娩の際にNAITに準じた慎重な管理が必要である。(著者抄録)
  • 佐野 実穂, 鈴木 寛正, 薄井 里英, 桑田 円, 横山 瑞浩, 堀江 健司, 高橋 宏典, 馬場 洋介, 大口 昭英, 松原 茂樹
    栃木県母性衛生学会雑誌: とちぼ 栃木県母性衛生学会 (42) 13  2016/03 [Not refereed][Not invited]
     
    40歳(2経妊0経産)。妊娠19週4日に出血と腹部膨満感を主訴に来院し、切迫流産の診断で入院となった。塩酸リトドリンの経静脈投与を66μg/分から開始し、炎症所見が軽快した後、21週0日に緊急マクドナルド頸管縫縮術を行った。その後、子宮収縮や頸管所見に応じてリトドリンを200μg/分まで徐々に増量した。母体の心拍数はリトドリン投与前が80bpm台、投与後が90〜110bpmであった。リトドリン投与55日目、起床時に突然の強い動悸を訴えた。脈拍は150〜170bpm、血圧は118/56mmHg、SpO2は97%、12誘導心電図は心拍数160bpm、R-R間隔は不整でP波を認めず、心房細動と診断した。心房細動の原因を明らかにするため、原因となりうる「心疾患」「電解質異常」「甲状腺機能亢進症」「薬剤」について鑑別診断を行った結果、「心疾患」「電解質異常」「甲状腺機能亢進症」は否定的であり、投与中
  • 横山 美樹, 廣瀬 典子, 鈴木 寛正, 高橋 宏典, 馬場 洋介, 薄井 里英, 大口 昭英, 松原 茂樹
    栃木県産婦人科医報 栃木県産科婦人科学会 42 53  2016/03 [Not refereed][Not invited]
     
    新生児同種免疫性血小板減少症(Neonatal alloimmune thrombocytopenia:NAIT)とは、免疫学的機序により起こる児の一過性血小板減少症であり、同胞罹患率が高い。母親に患児の血小板と反応する抗血小板抗体が証明されることが診断基準の一つであるが、原因抗体が明らかでない同胞発症症例を経験した。臨床経過からNAITが否定できない場合には、原因抗体が不明であっても次の妊娠分娩の際にNAITに準じた慎重な管理が必要である。(著者抄録)
  • 佐野 実穂, 鈴木 寛正, 薄井 里英, 桑田 円, 横山 瑞浩, 堀江 健司, 高橋 宏典, 馬場 洋介, 大口 昭英, 松原 茂樹
    栃木県母性衛生学会雑誌: とちぼ 栃木県母性衛生学会 (42) 13  2016/03 [Not refereed][Not invited]
     
    40歳(2経妊0経産)。妊娠19週4日に出血と腹部膨満感を主訴に来院し、切迫流産の診断で入院となった。塩酸リトドリンの経静脈投与を66μg/分から開始し、炎症所見が軽快した後、21週0日に緊急マクドナルド頸管縫縮術を行った。その後、子宮収縮や頸管所見に応じてリトドリンを200μg/分まで徐々に増量した。母体の心拍数はリトドリン投与前が80bpm台、投与後が90〜110bpmであった。リトドリン投与55日目、起床時に突然の強い動悸を訴えた。脈拍は150〜170bpm、血圧は118/56mmHg、SpO2は97%、12誘導心電図は心拍数160bpm、R-R間隔は不整でP波を認めず、心房細動と診断した。心房細動の原因を明らかにするため、原因となりうる「心疾患」「電解質異常」「甲状腺機能亢進症」「薬剤」について鑑別診断を行った結果、「心疾患」「電解質異常」「甲状腺機能亢進症」は否定的であり、投与中
  • 横山 美樹, 廣瀬 典子, 鈴木 寛正, 高橋 宏典, 馬場 洋介, 薄井 里英, 大口 昭英, 松原 茂樹
    栃木県産婦人科医報 栃木県産科婦人科学会 42 53  2016/03 [Not refereed][Not invited]
     
    新生児同種免疫性血小板減少症(Neonatal alloimmune thrombocytopenia:NAIT)とは、免疫学的機序により起こる児の一過性血小板減少症であり、同胞罹患率が高い。母親に患児の血小板と反応する抗血小板抗体が証明されることが診断基準の一つであるが、原因抗体が明らかでない同胞発症症例を経験した。臨床経過からNAITが否定できない場合には、原因抗体が不明であっても次の妊娠分娩の際にNAITに準じた慎重な管理が必要である。(著者抄録)
  • 佐野 実穂, 鈴木 寛正, 薄井 里英, 桑田 円, 横山 瑞浩, 堀江 健司, 高橋 宏典, 馬場 洋介, 大口 昭英, 松原 茂樹
    栃木県母性衛生学会雑誌: とちぼ 栃木県母性衛生学会 (42) 13  2016/03 [Not refereed][Not invited]
     
    40歳(2経妊0経産)。妊娠19週4日に出血と腹部膨満感を主訴に来院し、切迫流産の診断で入院となった。塩酸リトドリンの経静脈投与を66μg/分から開始し、炎症所見が軽快した後、21週0日に緊急マクドナルド頸管縫縮術を行った。その後、子宮収縮や頸管所見に応じてリトドリンを200μg/分まで徐々に増量した。母体の心拍数はリトドリン投与前が80bpm台、投与後が90〜110bpmであった。リトドリン投与55日目、起床時に突然の強い動悸を訴えた。脈拍は150〜170bpm、血圧は118/56mmHg、SpO2は97%、12誘導心電図は心拍数160bpm、R-R間隔は不整でP波を認めず、心房細動と診断した。心房細動の原因を明らかにするため、原因となりうる「心疾患」「電解質異常」「甲状腺機能亢進症」「薬剤」について鑑別診断を行った結果、「心疾患」「電解質異常」「甲状腺機能亢進症」は否定的であり、投与中
  • 横山 美樹, 廣瀬 典子, 鈴木 寛正, 高橋 宏典, 馬場 洋介, 薄井 里英, 大口 昭英, 松原 茂樹
    栃木県産婦人科医報 栃木県産科婦人科学会 42 53  2016/03 [Not refereed][Not invited]
     
    新生児同種免疫性血小板減少症(Neonatal alloimmune thrombocytopenia:NAIT)とは、免疫学的機序により起こる児の一過性血小板減少症であり、同胞罹患率が高い。母親に患児の血小板と反応する抗血小板抗体が証明されることが診断基準の一つであるが、原因抗体が明らかでない同胞発症症例を経験した。臨床経過からNAITが否定できない場合には、原因抗体が不明であっても次の妊娠分娩の際にNAITに準じた慎重な管理が必要である。(著者抄録)
  • 佐野 実穂, 鈴木 寛正, 薄井 里英, 桑田 円, 横山 瑞浩, 堀江 健司, 高橋 宏典, 馬場 洋介, 大口 昭英, 松原 茂樹
    栃木県母性衛生学会雑誌: とちぼ 栃木県母性衛生学会 (42) 13  2016/03 [Not refereed][Not invited]
     
    40歳(2経妊0経産)。妊娠19週4日に出血と腹部膨満感を主訴に来院し、切迫流産の診断で入院となった。塩酸リトドリンの経静脈投与を66μg/分から開始し、炎症所見が軽快した後、21週0日に緊急マクドナルド頸管縫縮術を行った。その後、子宮収縮や頸管所見に応じてリトドリンを200μg/分まで徐々に増量した。母体の心拍数はリトドリン投与前が80bpm台、投与後が90〜110bpmであった。リトドリン投与55日目、起床時に突然の強い動悸を訴えた。脈拍は150〜170bpm、血圧は118/56mmHg、SpO2は97%、12誘導心電図は心拍数160bpm、R-R間隔は不整でP波を認めず、心房細動と診断した。心房細動の原因を明らかにするため、原因となりうる「心疾患」「電解質異常」「甲状腺機能亢進症」「薬剤」について鑑別診断を行った結果、「心疾患」「電解質異常」「甲状腺機能亢進症」は否定的であり、投与中
  • 横山 美樹, 廣瀬 典子, 鈴木 寛正, 高橋 宏典, 馬場 洋介, 薄井 里英, 大口 昭英, 松原 茂樹
    栃木県産婦人科医報 栃木県産科婦人科学会 42 53  2016/03 [Not refereed][Not invited]
     
    新生児同種免疫性血小板減少症(Neonatal alloimmune thrombocytopenia:NAIT)とは、免疫学的機序により起こる児の一過性血小板減少症であり、同胞罹患率が高い。母親に患児の血小板と反応する抗血小板抗体が証明されることが診断基準の一つであるが、原因抗体が明らかでない同胞発症症例を経験した。臨床経過からNAITが否定できない場合には、原因抗体が不明であっても次の妊娠分娩の際にNAITに準じた慎重な管理が必要である。(著者抄録)
  • 佐野 実穂, 鈴木 寛正, 薄井 里英, 桑田 円, 横山 瑞浩, 堀江 健司, 高橋 宏典, 馬場 洋介, 大口 昭英, 松原 茂樹
    栃木県母性衛生学会雑誌: とちぼ 栃木県母性衛生学会 (42) 13  2016/03 [Not refereed][Not invited]
     
    40歳(2経妊0経産)。妊娠19週4日に出血と腹部膨満感を主訴に来院し、切迫流産の診断で入院となった。塩酸リトドリンの経静脈投与を66μg/分から開始し、炎症所見が軽快した後、21週0日に緊急マクドナルド頸管縫縮術を行った。その後、子宮収縮や頸管所見に応じてリトドリンを200μg/分まで徐々に増量した。母体の心拍数はリトドリン投与前が80bpm台、投与後が90〜110bpmであった。リトドリン投与55日目、起床時に突然の強い動悸を訴えた。脈拍は150〜170bpm、血圧は118/56mmHg、SpO2は97%、12誘導心電図は心拍数160bpm、R-R間隔は不整でP波を認めず、心房細動と診断した。心房細動の原因を明らかにするため、原因となりうる「心疾患」「電解質異常」「甲状腺機能亢進症」「薬剤」について鑑別診断を行った結果、「心疾患」「電解質異常」「甲状腺機能亢進症」は否定的であり、投与中
  • 横山 美樹, 廣瀬 典子, 鈴木 寛正, 高橋 宏典, 馬場 洋介, 薄井 里英, 大口 昭英, 松原 茂樹
    栃木県産婦人科医報 栃木県産科婦人科学会 42 53  2016/03 [Not refereed][Not invited]
     
    新生児同種免疫性血小板減少症(Neonatal alloimmune thrombocytopenia:NAIT)とは、免疫学的機序により起こる児の一過性血小板減少症であり、同胞罹患率が高い。母親に患児の血小板と反応する抗血小板抗体が証明されることが診断基準の一つであるが、原因抗体が明らかでない同胞発症症例を経験した。臨床経過からNAITが否定できない場合には、原因抗体が不明であっても次の妊娠分娩の際にNAITに準じた慎重な管理が必要である。(著者抄録)
  • 佐野 実穂, 鈴木 寛正, 薄井 里英, 桑田 円, 横山 瑞浩, 堀江 健司, 高橋 宏典, 馬場 洋介, 大口 昭英, 松原 茂樹
    栃木県母性衛生学会雑誌: とちぼ 栃木県母性衛生学会 (42) 13  2016/03 [Not refereed][Not invited]
     
    40歳(2経妊0経産)。妊娠19週4日に出血と腹部膨満感を主訴に来院し、切迫流産の診断で入院となった。塩酸リトドリンの経静脈投与を66μg/分から開始し、炎症所見が軽快した後、21週0日に緊急マクドナルド頸管縫縮術を行った。その後、子宮収縮や頸管所見に応じてリトドリンを200μg/分まで徐々に増量した。母体の心拍数はリトドリン投与前が80bpm台、投与後が90〜110bpmであった。リトドリン投与55日目、起床時に突然の強い動悸を訴えた。脈拍は150〜170bpm、血圧は118/56mmHg、SpO2は97%、12誘導心電図は心拍数160bpm、R-R間隔は不整でP波を認めず、心房細動と診断した。心房細動の原因を明らかにするため、原因となりうる「心疾患」「電解質異常」「甲状腺機能亢進症」「薬剤」について鑑別診断を行った結果、「心疾患」「電解質異常」「甲状腺機能亢進症」は否定的であり、投与中
  • 横山 美樹, 廣瀬 典子, 鈴木 寛正, 高橋 宏典, 馬場 洋介, 薄井 里英, 大口 昭英, 松原 茂樹
    栃木県産婦人科医報 栃木県産科婦人科学会 42 53  2016/03 [Not refereed][Not invited]
     
    新生児同種免疫性血小板減少症(Neonatal alloimmune thrombocytopenia:NAIT)とは、免疫学的機序により起こる児の一過性血小板減少症であり、同胞罹患率が高い。母親に患児の血小板と反応する抗血小板抗体が証明されることが診断基準の一つであるが、原因抗体が明らかでない同胞発症症例を経験した。臨床経過からNAITが否定できない場合には、原因抗体が不明であっても次の妊娠分娩の際にNAITに準じた慎重な管理が必要である。(著者抄録)
  • 佐野 実穂, 鈴木 寛正, 薄井 里英, 桑田 円, 横山 瑞浩, 堀江 健司, 高橋 宏典, 馬場 洋介, 大口 昭英, 松原 茂樹
    栃木県母性衛生学会雑誌: とちぼ 栃木県母性衛生学会 (42) 13  2016/03 [Not refereed][Not invited]
     
    40歳(2経妊0経産)。妊娠19週4日に出血と腹部膨満感を主訴に来院し、切迫流産の診断で入院となった。塩酸リトドリンの経静脈投与を66μg/分から開始し、炎症所見が軽快した後、21週0日に緊急マクドナルド頸管縫縮術を行った。その後、子宮収縮や頸管所見に応じてリトドリンを200μg/分まで徐々に増量した。母体の心拍数はリトドリン投与前が80bpm台、投与後が90〜110bpmであった。リトドリン投与55日目、起床時に突然の強い動悸を訴えた。脈拍は150〜170bpm、血圧は118/56mmHg、SpO2は97%、12誘導心電図は心拍数160bpm、R-R間隔は不整でP波を認めず、心房細動と診断した。心房細動の原因を明らかにするため、原因となりうる「心疾患」「電解質異常」「甲状腺機能亢進症」「薬剤」について鑑別診断を行った結果、「心疾患」「電解質異常」「甲状腺機能亢進症」は否定的であり、投与中
  • 横山 美樹, 廣瀬 典子, 鈴木 寛正, 高橋 宏典, 馬場 洋介, 薄井 里英, 大口 昭英, 松原 茂樹
    栃木県産婦人科医報 栃木県産科婦人科学会 42 53  2016/03 [Not refereed][Not invited]
     
    新生児同種免疫性血小板減少症(Neonatal alloimmune thrombocytopenia:NAIT)とは、免疫学的機序により起こる児の一過性血小板減少症であり、同胞罹患率が高い。母親に患児の血小板と反応する抗血小板抗体が証明されることが診断基準の一つであるが、原因抗体が明らかでない同胞発症症例を経験した。臨床経過からNAITが否定できない場合には、原因抗体が不明であっても次の妊娠分娩の際にNAITに準じた慎重な管理が必要である。(著者抄録)
  • 横山 美樹, 廣瀬 典子, 鈴木 寛正, 高橋 宏典, 馬場 洋介, 薄井 里英, 大口 昭英, 松原 茂樹
    栃木県産婦人科医報 栃木県産科婦人科学会 42 53  2016/03 [Not refereed][Not invited]
     
    新生児同種免疫性血小板減少症(Neonatal alloimmune thrombocytopenia:NAIT)とは、免疫学的機序により起こる児の一過性血小板減少症であり、同胞罹患率が高い。母親に患児の血小板と反応する抗血小板抗体が証明されることが診断基準の一つであるが、原因抗体が明らかでない同胞発症症例を経験した。臨床経過からNAITが否定できない場合には、原因抗体が不明であっても次の妊娠分娩の際にNAITに準じた慎重な管理が必要である。(著者抄録)
  • 佐野 実穂, 鈴木 寛正, 薄井 里英, 桑田 円, 横山 瑞浩, 堀江 健司, 高橋 宏典, 馬場 洋介, 大口 昭英, 松原 茂樹
    栃木県母性衛生学会雑誌: とちぼ 栃木県母性衛生学会 (42) 13  2016/03 [Not refereed][Not invited]
     
    40歳(2経妊0経産)。妊娠19週4日に出血と腹部膨満感を主訴に来院し、切迫流産の診断で入院となった。塩酸リトドリンの経静脈投与を66μg/分から開始し、炎症所見が軽快した後、21週0日に緊急マクドナルド頸管縫縮術を行った。その後、子宮収縮や頸管所見に応じてリトドリンを200μg/分まで徐々に増量した。母体の心拍数はリトドリン投与前が80bpm台、投与後が90〜110bpmであった。リトドリン投与55日目、起床時に突然の強い動悸を訴えた。脈拍は150〜170bpm、血圧は118/56mmHg、SpO2は97%、12誘導心電図は心拍数160bpm、R-R間隔は不整でP波を認めず、心房細動と診断した。心房細動の原因を明らかにするため、原因となりうる「心疾患」「電解質異常」「甲状腺機能亢進症」「薬剤」について鑑別診断を行った結果、「心疾患」「電解質異常」「甲状腺機能亢進症」は否定的であり、投与中
  • S. Matsubara, Y. Baba, H. Morisawa, H. Takahashi, A. K. Lefor
    EUROPEAN JOURNAL OF OBSTETRICS & GYNECOLOGY AND REPRODUCTIVE BIOLOGY 198 177 - 178 0301-2115 2016/03 [Refereed][Not invited]
  • 横山 美樹, 廣瀬 典子, 鈴木 寛正, 高橋 宏典, 馬場 洋介, 薄井 里英, 大口 昭英, 松原 茂樹
    栃木県産婦人科医報 栃木県産科婦人科学会 42 53  2016/03 [Not refereed][Not invited]
     
    新生児同種免疫性血小板減少症(Neonatal alloimmune thrombocytopenia:NAIT)とは、免疫学的機序により起こる児の一過性血小板減少症であり、同胞罹患率が高い。母親に患児の血小板と反応する抗血小板抗体が証明されることが診断基準の一つであるが、原因抗体が明らかでない同胞発症症例を経験した。臨床経過からNAITが否定できない場合には、原因抗体が不明であっても次の妊娠分娩の際にNAITに準じた慎重な管理が必要である。(著者抄録)
  • 佐野 実穂, 鈴木 寛正, 薄井 里英, 桑田 円, 横山 瑞浩, 堀江 健司, 高橋 宏典, 馬場 洋介, 大口 昭英, 松原 茂樹
    栃木県母性衛生学会雑誌: とちぼ 栃木県母性衛生学会 (42) 13  2016/03 [Not refereed][Not invited]
     
    40歳(2経妊0経産)。妊娠19週4日に出血と腹部膨満感を主訴に来院し、切迫流産の診断で入院となった。塩酸リトドリンの経静脈投与を66μg/分から開始し、炎症所見が軽快した後、21週0日に緊急マクドナルド頸管縫縮術を行った。その後、子宮収縮や頸管所見に応じてリトドリンを200μg/分まで徐々に増量した。母体の心拍数はリトドリン投与前が80bpm台、投与後が90〜110bpmであった。リトドリン投与55日目、起床時に突然の強い動悸を訴えた。脈拍は150〜170bpm、血圧は118/56mmHg、SpO2は97%、12誘導心電図は心拍数160bpm、R-R間隔は不整でP波を認めず、心房細動と診断した。心房細動の原因を明らかにするため、原因となりうる「心疾患」「電解質異常」「甲状腺機能亢進症」「薬剤」について鑑別診断を行った結果、「心疾患」「電解質異常」「甲状腺機能亢進症」は否定的であり、投与中
  • Takahashi Hironori, Ohkuchi Akihide, Ishida Yoichi, Takizawa Toshihiro, Matsubara Shigeki
    Acta Obstetrica et Gynaecologica Japonica 社団法人日本産科婦人科学会 68 (2) 0300-9165 2016/02 [Not refereed][Not invited]
  • Takahashi Hironori, Ohkuchi Akihide, Ishida Yoichi, Takizawa Toshihiro, Matsubara Shigeki
    Acta Obstetrica et Gynaecologica Japonica 社団法人日本産科婦人科学会 68 (2) 0300-9165 2016/02 [Not refereed][Not invited]
  • Takahashi Hironori, Ohkuchi Akihide, Ishida Yoichi, Takizawa Toshihiro, Matsubara Shigeki
    Acta Obstetrica et Gynaecologica Japonica 社団法人日本産科婦人科学会 68 (2) 0300-9165 2016/02 [Not refereed][Not invited]
  • Takahashi Hironori, Ohkuchi Akihide, Ishida Yoichi, Takizawa Toshihiro, Matsubara Shigeki
    Acta Obstetrica et Gynaecologica Japonica 社団法人日本産科婦人科学会 68 (2) 0300-9165 2016/02 [Not refereed][Not invited]
  • Takahashi Hironori, Ohkuchi Akihide, Ishida Yoichi, Takizawa Toshihiro, Matsubara Shigeki
    Acta Obstetrica et Gynaecologica Japonica 社団法人日本産科婦人科学会 68 (2) 0300-9165 2016/02 [Not refereed][Not invited]
  • Takahashi Hironori, Ohkuchi Akihide, Ishida Yoichi, Takizawa Toshihiro, Matsubara Shigeki
    Acta Obstetrica et Gynaecologica Japonica 社団法人日本産科婦人科学会 68 (2) 0300-9165 2016/02 [Not refereed][Not invited]
  • Takahashi Hironori, Ohkuchi Akihide, Ishida Yoichi, Takizawa Toshihiro, Matsubara Shigeki
    Acta Obstetrica et Gynaecologica Japonica 社団法人日本産科婦人科学会 68 (2) 0300-9165 2016/02 [Not refereed][Not invited]
  • Takahashi Hironori, Ohkuchi Akihide, Ishida Yoichi, Takizawa Toshihiro, Matsubara Shigeki
    Acta Obstetrica et Gynaecologica Japonica 社団法人日本産科婦人科学会 68 (2) 0300-9165 2016/02 [Not refereed][Not invited]
  • Takahashi Hironori, Ohkuchi Akihide, Ishida Yoichi, Takizawa Toshihiro, Matsubara Shigeki
    Acta Obstetrica et Gynaecologica Japonica 社団法人日本産科婦人科学会 68 (2) 0300-9165 2016/02 [Not refereed][Not invited]
  • Takahashi Hironori, Ohkuchi Akihide, Ishida Yoichi, Takizawa Toshihiro, Matsubara Shigeki
    Acta Obstetrica et Gynaecologica Japonica 社団法人日本産科婦人科学会 68 (2) 0300-9165 2016/02 [Not refereed][Not invited]
  • Takahashi Hironori, Ohkuchi Akihide, Ishida Yoichi, Takizawa Toshihiro, Matsubara Shigeki
    Acta Obstetrica et Gynaecologica Japonica 社団法人日本産科婦人科学会 68 (2) 0300-9165 2016/02 [Not refereed][Not invited]
  • Takahashi Hironori, Ohkuchi Akihide, Ishida Yoichi, Takizawa Toshihiro, Matsubara Shigeki
    Acta Obstetrica et Gynaecologica Japonica 社団法人日本産科婦人科学会 68 (2) 0300-9165 2016/02 [Not refereed][Not invited]
  • Takahashi Hironori, Ohkuchi Akihide, Ishida Yoichi, Takizawa Toshihiro, Matsubara Shigeki
    Acta Obstetrica et Gynaecologica Japonica 社団法人日本産科婦人科学会 68 (2) 0300-9165 2016/02 [Not refereed][Not invited]
  • Takahashi Hironori, Ohkuchi Akihide, Ishida Yoichi, Takizawa Toshihiro, Matsubara Shigeki
    Acta Obstetrica et Gynaecologica Japonica 社団法人日本産科婦人科学会 68 (2) 0300-9165 2016/02 [Not refereed][Not invited]
  • Takahashi Hironori, Ohkuchi Akihide, Ishida Yoichi, Takizawa Toshihiro, Matsubara Shigeki
    Acta Obstetrica et Gynaecologica Japonica 社団法人日本産科婦人科学会 68 (2) 0300-9165 2016/02 [Not refereed][Not invited]
  • Takahashi Hironori, Ohkuchi Akihide, Ishida Yoichi, Takizawa Toshihiro, Matsubara Shigeki
    Acta Obstetrica et Gynaecologica Japonica 社団法人日本産科婦人科学会 68 (2) 0300-9165 2016/02 [Not refereed][Not invited]
  • Takahashi Hironori, Ohkuchi Akihide, Ishida Yoichi, Takizawa Toshihiro, Matsubara Shigeki
    Acta Obstetrica et Gynaecologica Japonica 社団法人日本産科婦人科学会 68 (2) 0300-9165 2016/02 [Not refereed][Not invited]
  • Takahashi Hironori, Ohkuchi Akihide, Ishida Yoichi, Takizawa Toshihiro, Matsubara Shigeki
    Acta Obstetrica et Gynaecologica Japonica 社団法人日本産科婦人科学会 68 (2) 0300-9165 2016/02 [Not refereed][Not invited]
  • Takahashi Hironori, Ohkuchi Akihide, Ishida Yoichi, Takizawa Toshihiro, Matsubara Shigeki
    Acta Obstetrica et Gynaecologica Japonica 社団法人日本産科婦人科学会 68 (2) 0300-9165 2016/02 [Not refereed][Not invited]
  • Takahashi Hironori, Ohkuchi Akihide, Ishida Yoichi, Takizawa Toshihiro, Matsubara Shigeki
    Acta Obstetrica et Gynaecologica Japonica 社団法人日本産科婦人科学会 68 (2) 0300-9165 2016/02 [Not refereed][Not invited]
  • Takahashi Hironori, Ohkuchi Akihide, Ishida Yoichi, Takizawa Toshihiro, Matsubara Shigeki
    Acta Obstetrica et Gynaecologica Japonica 社団法人日本産科婦人科学会 68 (2) 0300-9165 2016/02 [Not refereed][Not invited]
  • Takahashi Hironori, Ohkuchi Akihide, Ishida Yoichi, Takizawa Toshihiro, Matsubara Shigeki
    Acta Obstetrica et Gynaecologica Japonica 社団法人日本産科婦人科学会 68 (2) 0300-9165 2016/02 [Not refereed][Not invited]
  • Shigeki Matsubara, Hironori Takahashi, Akihide Ohkuchi, Alan K. Lefor
    AUSTRALIAN & NEW ZEALAND JOURNAL OF OBSTETRICS & GYNAECOLOGY 56 (1) 117 - 117 0004-8666 2016/02 [Refereed][Not invited]
  • Takahashi Hironori, Ohkuchi Akihide, Ishida Yoichi, Takizawa Toshihiro, Matsubara Shigeki
    Acta Obstetrica et Gynaecologica Japonica 社団法人日本産科婦人科学会 68 (2) 0300-9165 2016/02 [Not refereed][Not invited]
  • Shigeki Matsubara, Hiroyuki Fujiwara, Akihide Ohkuchi, Hironori Takahashi, Alan K. Lefor
    ACTA OBSTETRICIA ET GYNECOLOGICA SCANDINAVICA 95 (1) 119 - 119 0001-6349 2016/01 [Refereed][Not invited]
  • Hironori Takahashi, Akihide Ohkuchi, Rie Usui, Hirotada Suzuki, Yosuke Baba, Shigeki Matsubara
    Obstetrics and Gynecology International 2016 5349063  1687-9597 2016 [Refereed][Not invited]
     
    Introduction. To identify factors that determine blood loss during peripartum hysterectomy for abnormally invasive placenta (AIP-hysterectomy). Methods. We reviewed all of the medical charts of 11,919 deliveries in a single tertiary perinatal center. We examined characteristics of AIP-hysterectomy patients, with a single experienced obstetrician attending all AIP-hysterectomies and using the same technique. Results. AIP-hysterectomy was performed in 18 patients (0.15%: 18/11,919). Of the 18, 14 (78%) had a prior cesarean section (CS) history and the other 4 (22%) were primiparous women. Planned AIP-hysterectomy was performed in 12/18 (67%), with the remaining 6 (33%) undergoing emergent AIP-hysterectomy. Of the 6, 4 (4/6: 67%) patients were primiparous women. An intra-arterial balloon was inserted in 9/18 (50%). Women with the following three factors significantly bled less in AIP-hysterectomy than its counterpart: the employment of an intra-arterial balloon (4, 448 ± 1, 948 versus 8, 861 ± 3, 988 mL), planned hysterectomy (5, 003 ± 2, 057 versus 9, 957 ± 4, 485 mL), and prior CS (5, 706 ± 2, 727 versus 9, 975 ± 5, 532 mL). Patients with prior CS (-) bled more: this may be because these patients tended to undergo emergent surgery or attempted placental separation. Conclusion. Patients with intra-arterial balloon catheter insertion bled less on AIP-hysterectomy. Massive bleeding occurred in emergent AIP-hysterectomy without prior CS.
  • Baba Y, Morisawa H, Saito K, Takahashi H, Rifu K, Matsubara S
    Case reports in obstetrics and gynecology 2016 5384943  2090-6684 2016 [Refereed][Not invited]
  • Matsubara S, Fujiwara H, Ohkuchi A, Takahashi H, Lefor AK
    Acta obstetricia et gynecologica Scandinavica Wiley-Blackwell 95 (1) 119  0001-6349 2016/01 [Refereed][Not invited]
  • Shigeki Matsubara, Hironori Takahashi, Rie Usui, Hiroyuki Morisawa, Hiroyasu Nakamura, Yuji Takei
    JOURNAL OF MATERNAL-FETAL & NEONATAL MEDICINE 29 (19) 3151 - 3152 1476-7058 2016 [Refereed][Not invited]
  • Hiroyuki Morisawa, Shinji Makino, Hironori Takahashi, Mari Sorita, Shigeki Matsubara
    JOURNAL OF OBSTETRICS AND GYNAECOLOGY RESEARCH 41 (11) 1835 - 1838 1341-8076 2015/11 [Refereed][Not invited]
     
    Serous retinal detachment is sometimes caused by hypertensive disorders in pregnancy and its associated conditions, in which the predominant eye symptoms are blurred vision, distorted vision, and reduced visual acuity. To our best knowledge, this is the first report of a puerperal woman with hemolysis, elevated liver enzymes, and low platelet count (HELLP) syndrome in whom color vision abnormality was the first and predominant manifestation of serous retinal detachment. At 32 weeks of gestation, the 34-year-old Japanese woman underwent cesarean section due to HELLP syndrome. She complained of color vision abnormality on day 1 post-partum and ophthalmological examination revealed serous retinal detachment of both eyes. The visual acuity was preserved. With supportive therapy, her color vision abnormality gradually ameliorated and retinal detachment completely resolved on day 34 post-partum without any sequelae. Obstetricians should be aware that color vision abnormality can be the first and predominant symptom of HELLP-related serous retinal detachment.
  • Shigeki Matsubara, Hironori Takahashi, Yosuke Baba, Rie Usui, Takashi Igarashi, Alan K. Lefor
    ARCHIVES OF GYNECOLOGY AND OBSTETRICS 292 (5) 953 - 954 0932-0067 2015/11 [Refereed][Not invited]
  • Matsubara S, Takahashi H, Lefor AK
    Minerva ginecologica 67 (5) 488 - 489 0026-4784 2015/10 [Refereed][Not invited]
  • Shigeki Matsubara, Hironori Takahashi, Yosuke Baba, Rie Usui
    ACTA OBSTETRICIA ET GYNECOLOGICA SCANDINAVICA 94 (10) 1147 - 1148 0001-6349 2015/10 [Refereed][Not invited]
  • Shigeki Matsubara, Hironori Takahashi, Akihide Ohkuchi
    JOURNAL OF OBSTETRICS AND GYNAECOLOGY RESEARCH 41 (10) 1676 - 1676 1341-8076 2015/10 [Refereed][Not invited]
  • Takahashi Hironori, Zhao Dongwei, Ohkuchi Akihide, Matsubara Shigeki, Takizawa Toshihiro
    PLACENTA 36 (9) A22  0143-4004 2015/09 [Refereed][Not invited]
  • Hironori Takahashi, Shigeki Matsubara
    ACTA OBSTETRICIA ET GYNECOLOGICA SCANDINAVICA 94 (6) 670 - 671 0001-6349 2015/06 [Refereed][Not invited]
  • Shigeki Matsubara, Akihide Ohkuchi, Hirotada Suzuki, Madoka Kimura, Hironori Takahashi, Hiroyuki Fujiwara
    ACTA OBSTETRICIA ET GYNECOLOGICA SCANDINAVICA 94 (5) 552 - 553 0001-6349 2015/05 [Refereed][Not invited]
  • Hironori Takahashi, Shigeki Matsubara
    ACTA OBSTETRICIA ET GYNECOLOGICA SCANDINAVICA 94 (5) 557 - 557 0001-6349 2015/05 [Refereed][Not invited]
  • Hironori Takahashi, Shigeki Matsubara, Mami Kobayashi, Akihide Ohkuchi
    ACTA OBSTETRICIA ET GYNECOLOGICA SCANDINAVICA 94 (3) 336 - 336 0001-6349 2015/03 [Refereed][Not invited]
  • Shigeki Matsubara, Tomoyuki Kuwata, Hironori Takahashi, Yukio Kimura
    JOURNAL OF OBSTETRICS AND GYNAECOLOGY RESEARCH 41 (3) 488 - 488 1341-8076 2015/03 [Refereed][Not invited]
  • Matsubara S, Takahashi H, Lefor AK
    Frontiers in surgery 2 17  2015 [Refereed][Not invited]
  • Matsubara S, Takahashi H, Lefor AK
    Obstetrics and gynecology international 2015 279513  1687-9589 2015 [Refereed][Not invited]
  • Hironori Takahashi, Yosuke Baba, Shigeki Matsubara
    ACTA OBSTETRICIA ET GYNECOLOGICA SCANDINAVICA 93 (12) 1336 - 1336 0001-6349 2014/12 [Refereed][Not invited]
  • Hironori Takahashi, Akihide Ohkuchi, Tomoyuki Kuwata, Rie Usui, Kunio Kikuchi, Shigeki Matsubara, Mitsuaki Suzuki, Toshiyuki Takeshita, Toshihiro Takizawa
    PLACENTA 35 (10) A22 - A23 0143-4004 2014/10 [Refereed][Not invited]
  • Hironori Takahashi, Akihide Ohkuchi, Takami Takizawa, Shigeki Matsubara, Rie Usui, Tomoyuki Kuwata, Mitsuaki Suzuki, Toshihiro Takizawa
    PLACENTA 35 (9) A66 - A67 0143-4004 2014/09 [Refereed][Not invited]
  • Shigeki Matsubara, Tomoyuki Kuwata, Yosuke Baba, Rie Usui, Hirotada Suzuki, Hironori Takahashi, Akihide Ohkuchi, Mitsuaki Suzuki
    AUSTRALIAN & NEW ZEALAND JOURNAL OF OBSTETRICS & GYNAECOLOGY 54 (3) 283 - 286 0004-8666 2014/06 [Refereed][Not invited]
     
    Although massive haemorrhage at caesarean section (CS) for placenta praevia is a serious concern, effective treatment is not yet determined. We performed a new uterine sandwich to achieve haemostasis at CS for total placenta praevia in five consecutive cases in whom the placenta reached up to >5cm from the internal cervical os in all directions of an uterine wall. A Matsubara-Yano (MY) uterine compression suture was placed, followed by placement of an intrauterine balloon. Haemostasis was achieved in all five cases with median blood loss of 1618mL. No short-term adverse events were observed. The MY sandwich can be used to achieve haemostasis at CS for placenta praevia.
  • Hironori Takahashi, Kazuya Yuge, Shigeki Matsubara, Akihide Ohkuchi, Tomoyuki Kuwata, Rie Usui, Mitsuaki Suzuki, Toshihiro Takizawa
    JOURNAL OF NIPPON MEDICAL SCHOOL 81 (3) 122 - 129 1345-4676 2014/06 [Refereed][Not invited]
     
    A disintegrin and metalloproteinases (ADAMs) are members of the metzincin family of zinc-dependent metalloproteinases that play pivotal roles in the proteolytic degradation of the extracellular matrix for cell invasion. Few studies have investigated the ADAM subtypes that are expressed in first trimester trophoblast cells. The purpose of this study was to elucidate the differential expression profiles of ADAMs between first trimester villous trophoblast cells (VTs) and extravillous trophoblast cells (EVTs). We isolated EVTs from explanted human first trimester chorionic villi and investigated the mRNA expression levels of five members of the ADAM family (ADAMTS1, ADAMTS2, ADAM10, ADAM12, and ADAM17) using real-time PCR. Chorionic villous tips were defined as first trimester VTs. Of the differentially expressed ADAM genes between first trimester VTs and EVTs, ADAMTS1 was expressed at a significantly higher level in EVTs than in VTs. In contrast, both ADAM10 and ADAM12 were expressed at significantly higher levels in VTs than in EVTs. No differences were found in the mRNA levels of ADAMTS2 and ADAM17 between the two cell types. Moreover, we demonstrated that in VTs, the expression level of ADAM12 was significantly downregulated in the late first trimester (10-13 gestational weeks) compared to the middle first trimester (7-8 weeks). These results suggest that first trimester trophoblast cells express ADAM genes in cell type- and gestational age-dependent manners. Our data provide additional insight into the functions of ADAMs in the human placenta.
  • Yosuke Baba, Shigeki Matsubara, Akihide Ohkuchi, Rie Usui, Tomoyuki Kuwata, Hirotada Suzuki, Hironori Takahashi, Mitsuaki Suzuki
    JOURNAL OF OBSTETRICS AND GYNAECOLOGY RESEARCH 40 (5) 1243 - 1248 1341-8076 2014/05 [Refereed][Not invited]
     
    AimIn placenta previa (PP), anterior placentation, compared with posterior placentation, is reported to more frequently cause massive hemorrhage during cesarean section (CS). Whether this is due to the high incidence of placenta accreta, previous CS, or a transplacental approach in anterior placenta is unclear. We attempted to clarify this issue. Material and MethodsWe retrospectively analyzed the relation between the bleeding amount during CS for PP and various factors that may cause massive hemorrhage (>2400mL) (n=205) in a tertiary center. If the preoperatively ultrasound-measured distance from the internal cervical ostium to the placental edge was longer in the uterine anterior wall than in the posterior wall, we defined it as anterior previa, and vice versa. ResultsPatients with accreta, previous CS, total previa, and anterior placentation bled significantly more than their counterparts. Multivariate logistic regression analysis showed that accreta (odds ratio [OR] 12.6), previous CS (OR 4.7), total previa (OR 4.1), and anterior placentation (OR 3.5) were independent risk factors of massive hemorrhage. ConclusionsAnterior placentation, namely, the placenta with a longer os-placental edge distance in the anterior wall than in the posterior wall, was a risk of massive hemorrhage during CS for PP.
  • Hironori Takahashi, Shigeki Matsubara, Tomoyuki Kuwata, Akihide Ohkuchi, Yukiko Mukoda, Koyomi Saito, Rie Usui, Mitsuaki Suzuki
    JOURNAL OF OBSTETRICS AND GYNAECOLOGY RESEARCH 40 (4) 1114 - 1117 1341-8076 2014/04 [Refereed][Not invited]
     
    Various fetal or placental disorders cause Ballantyne's (mirror) syndrome. For the first time, we report a maternal manifestation of Ballantyne's syndrome occurring concomitantly with the development of fetal congenital mesoblastic nephroma (CMN). In a pregnant woman with a CMN fetus, lung edema, hypertension, hyperthyroidism, and high serum human chorionic gonadotrophin level occurred, all of which characterize maternal manifestation of Ballantyne's syndrome. The fetus and placenta were devoid of edema', lacking triple edema', and thus this condition was not diagnosed as Ballantyne's syndrome; however, we considered this condition as the maternal manifestation of Ballantyne's syndrome. We performed emergent cesarean section at 28 weeks. Delivery acutely ameliorated maternal symptoms. Tumor was resected and was confirmed as CMN. Maternal manifestations of Ballantyne's syndrome, such as lung edema and hypertension, can occur in a mother with fetal CMN even without fetal and/or placental edema. The clinical course of this patient may suggest an etiology of Ballantyne's syndrome.
  • Hironori Takahashi, Shigeki Matsubara, Tomoyuki Kuwata, Miyuki Saruyama, Rie Usui, Akihide Ohkuchi, Toshihiro Takizawa, Mitsuaki Suzuki
    JOURNAL OF OBSTETRICS AND GYNAECOLOGY RESEARCH 40 (4) 1145 - 1149 1341-8076 2014/04 [Refereed][Not invited]
     
    A recent report indicated that vascular endothelial growth factor (VEGF)-D, regulating cell proliferation and/or differentiation, may be associated with the development of placental mesenchymal dysplasia (PMD), a disorder characterized by cell proliferation/differentiation. In PMD placenta, we examined the expression of five cell-proliferation/differentiation-associated genes, namely, Wnt3a, Wnt5a, -catenin, VEGF-D and Dickkopf-1 (DKK-1). In PMD, expressions of Wnt3a, Wnt5a and -catenin were decreased, whereas those of VEGF-D and DKK-1 were increased. These abnormal expressions suggest a relationship between these genes and PMD pathogenesis/pathophysiology.
  • Hironori Takahashi, Shigeki Matsubara, Koyomi Saito, Masashi Bando
    AUSTRALIAN & NEW ZEALAND JOURNAL OF OBSTETRICS & GYNAECOLOGY 54 (2) 191 - 191 0004-8666 2014/04 [Refereed][Not invited]
  • T. Kuwata, H. Takahashi, S. Matsubara
    ULTRASOUND IN OBSTETRICS & GYNECOLOGY 43 (3) 355 - 355 0960-7692 2014/03 [Refereed][Not invited]
  • H. Takahashi, T. Takizawa, S. Matsubara, A. Ohkuchi, T. Kuwata, R. Usui, H. Matsumoto, Y. Sato, H. Fujiwara, A. Okamoto, M. Suzuki, T. Takizawa
    PLACENTA 35 (3) 163 - 170 0143-4004 2014/03 [Refereed][Not invited]
     
    Introduction: Extravillous trophoblast (EVT) cell invasion plays a crucial role in establishment of successful pregnancy. CD44, a cell-surface receptor for hyaluronic acid (HA), plays a key role in HA-mediated remodeling and degradation that triggers cancer cell invasion. However, few studies have reported on the expression or functions of CD44 in human EVT cells. We hypothesized that CD44-HA interaction was involved in invasion by EVT cells. Methods: To test our hypothesis, we conducted in situ examinations of CD44 and HA expression in the human first-trimester placenta. We also assessed the methylation status of CD44 promoter and exon 1 regions in EVT cells. Finally, we conducted transwell cell invasion assays using EVT cell lines and EVT cells isolated from first-trimester human villous explant cultures. Results and discussion: EVT cells, but not villous trophoblast cells, in the first-trimester placenta expressed CD44. HA was strongly expressed in adventitia surrounding the spiral uterine arterial walls of the decidua. The extent of demethylation of CD44 promoter and exon 1 CpG islands was increased in EVT cells compared to those of first-trimester chorionic villi (including villous trophoblast cells), suggesting that CD44 expression was, at least in part, associated with methylation status. Data from transwell cell invasion assay with siRNA knockdown of CD44 revealed that CD44 expression significantly promoted invasion by EVT cells in an HA-dependent manner. Conclusions: The discovery of a CD44-HA interaction between EVT cells and the extracellular matrix contributes to our understanding of the mechanism underlying invasion by EVT cells. (C) 2013 Elsevier Ltd. All rights reserved.
  • Hironori Takahashi, Michi Hisano, Haruhiko Sago, Atsuko Murashima, Koushi Yamaguchi
    HYPERTENSION IN PREGNANCY 33 (1) 55 - 60 1064-1955 2014 [Refereed][Not invited]
     
    Objective: To find a risk factor for "uncomplicated" preeclampsia (PE) comparing blood biochemical parameters between women with uncomplicated PE and healthy pregnant women in each trimester of pregnancy. Methods: A retrospective study was performed on 83 cases of uncomplicated PE, selected from 434 patients with PE, disregarding subjects with other complications relevant to hypertension during pregnancy. The study was limited to women with PE occurring in the third trimester, and records of blood biochemical parameters were evaluated. Controls were recruited from 108 healthy volunteers with normal singleton pregnancies. Results: A significant decrease in total protein was observed in the uncomplicated PE group in the second trimester prior to the onset of clinical symptoms. Conclusion: Hypoproteinemia during pregnancy may be a risk factor for this pathophysiology, and the maintenance of sufficient protein in early pregnancy could contribute to prophylaxis for women with uncomplicated PE.
  • Takahashi Hironori, Yoshitake Hiroshi, Matsubara Shigeki, Ohkuchi Akihide, Kuwata Tomoyuki, Usui Rie, Okamoto Aikou, Suzuki Mitsuaki, Takizawa Toshihiro
    PLACENTA 34 (10) A4  0143-4004 2013/10 [Refereed][Not invited]
  • Takahashi Hironori, Kikuchi Kunio, Kuwata Tomoyuki, Usui Rie, Ohkuchi Akihide, Matsumoto Hisanori, Sato Yukiyasu, Fujiwara Hiroshi, Ui-Tei Kumiko, Matsubara Shigeki, Suzuki Mitsuaki, Takazawa Toshihiro
    PLACENTA 33 (9) A51  0143-4004 2012/09 [Refereed][Not invited]
  • Kikuchi Kunio, Qu Guangjin, Takahashi Hironori, Kuwata Tomoyuki, Usui Rie, Ohkuchi Akihide, Luo Shan-shun, Matsubara Shigeki, Suzuki Mitsuaki, Takizawa Toshihiro
    PLACENTA 33 (9) A77  0143-4004 2012/09 [Refereed][Not invited]
  • Akane Miyata, Hironori Takahashi, Takahiko Kubo, Noriyoshi Watanabe, Keiko Tsukamoto, Yushi Ito, Haruhiko Sago
    JOURNAL OF OBSTETRICS AND GYNAECOLOGY RESEARCH 38 (8) 1052 - 1056 1341-8076 2012/08 [Refereed][Not invited]
     
    Aim: We investigated trends in early-onset group B streptococcal disease (EOD) after the introduction of culture-based screening in Japan. Material and Methods: A retrospective cohort study examined EOD trends in 9506 pregnancies and 10 715 neonates at our center from 2002 to 2009. Results: EOD occurred in four neonates (4/7332: 0.55/1000 live births). The EOD incidence among infants born to women positive for GBS by screening was 0.90 cases per 1000 live births (1/1107). In contrast, the EOD incidence among infants negative by GBS screening was 0.48 cases per 1000 live births (3/6225). Thus, of the four affected neonates, three had mothers who tested negative on antepartum GBS screening. Two neonates had symptoms of infection during labor and intrapartum antibiotic agents were administered. The other two neonates received no antibiotics because deliveries were uneventful and they were negative on GBS screening. Conclusion: The incidence of EOD is 0.90 cases per 1000 live births among GBS-positive women and 0.48 cases per 1000 live births among GBS-negative women. The results of our study implied that EOD can develop regardless of GBS screening and intrapartum clinical course, although the method of sample collection, indications for antibiotic prophylaxis, and the antibiotics regimen should be considered.
  • Hironori Takahashi, Shigehiro Takahashi, Keiko Tsukamoto, Yushi Ito, Tomoo Nakamura, Satoshi Hayashi, Haruhiko Sago
    JOURNAL OF MATERNAL-FETAL & NEONATAL MEDICINE 25 (5) 543 - 545 1476-7058 2012/05 [Refereed][Not invited]
     
    Objective: We investigated persistent pulmonary hypertension of the newborn (PPHN) among monochorionic-diamniotic (MD) twins. Methods: A retrospective cohort study examined MD twins from 195 deliveries and 373 live-born neonates at our center. Results: PPHN occurred in three cases (3/373: 0.8%), all of which were recipients of twin-twin transfusion syndrome (TTTS), after fetoscopic laser surgery (FLS) (3/117: 2.6%). Although the clinical course of the three cases differed, all cardiothoracic area ratios exceeded 40%, and other cardiac parameters also worsened after FLS. Conclusions: The occurrence of PPHN in TTTS recipients should be noted, particularly when fetal cardiac function declines following FLS.
  • Hironori Takahashi, Noriyoshi Watanabe, Rika Sugibayashi, Hiroaki Aoki, Makiko Egawa, Aiko Sasaki, Yuki Tsukahara, Takahiko Kubo, Haruhiko Sago
    ARCHIVES OF GYNECOLOGY AND OBSTETRICS 285 (4) 937 - 941 0932-0067 2012/04 [Refereed][Not invited]
     
    To investigate perinatal outcomes in late primiparous women aged 35-39 and >= 40 years. Our main research question: "Was the rate of cesarean section similar between these 2 groups of advanced maternal age?" Primiparous women aged >= 35 years, who delivered in our center between April 2004 and March 2007, were enrolled in this study. They were divided into two groups: women aged 35-39 years and those aged >= 40 years. Antenatal complications, deliveries, and neonatal outcomes were analyzed. Fetal abnormalities, abortions, and multiple gestations were excluded. We assessed 752 cases (35-39 years, 610 cases; >= 40 years, 142 cases). Incidence of cesarean section (CS) was significantly higher in pregnant women aged >= 40 years (P < 0.01). The CS rate amounted to 50.0% of all deliveries in this age group. Among patients with labor deliveries, the CS rate was also significantly higher in the older age group (P < 0.05). With regard to indication for CS with labor deliveries, the rate of non-progressive labor/dystocia was 19.4% in primiparous women aged >= 40 years and 11.0% in those aged 35-39 years, respectively (P < 0.05). In contrast, the rates of antenatal complications were not different between the two groups, except for gestational diabetes or leiomyoma. No significant differences between the two groups could be found for neonatal outcomes such as birth weight, Apgar score, and admission to neonatal intensive care unit. CS rate was 50.0% in primiparous women aged >= 40 years. In addition, CS caused by dystocia was almost twice as frequent in primiparous women aged >= 40 years as in women aged 35-39 years. Among late pregnancies, primiparous women aged 40 years and older had higher risk of CS.
  • Takahashi H, Tsukamoto K, Takahashi S, Nakamura T, Ito Y, Kaneko M, Sago H
    AJP reports 1 (1) 37 - 42 2157-6998 2011/09 [Refereed][Not invited]
  • Hironori Takahashi, Satoshi Hayashi, Kentaro Matsuoka, Michihiro Kitagawa
    TAIWANESE JOURNAL OF OBSTETRICS & GYNECOLOGY 49 (2) 197 - 198 1028-4559 2010/06 [Refereed][Not invited]
     
    Objective: Uterine artery embolization (UAE) is becoming a common treatment for symptomatic leiomyoma Several pregnancies following UAE have been reported However, reports are still limited and the risk of complications remains unknown Case Report: A primigravida conceived after UAE for leiomyoma She delivered spontaneously at 34 weeks plus 2 days after premature rupture of the membranes The placenta was located on the interstitial leiomyoma. The patient required manual placental extraction owing to retained placenta and subsequently underwent emergency supracervical hysterectomy for severe postpartum hemorrhage Placenta accreta was confirmed histologically Conclusion: Placenta accreta may occur during pregnancy following UAE When the implantation site is on the leiomyoma with a hyperechoic rim, there is a high risk of abnormal placental adherence [Taiwan J Obstet Gynecol 2010,49(2) 197-198]
  • Takahashi H, Hayashi S, Miura Y, Tsukamoto K, Kosaki R, Itoh Y, Sago H
    Obstetrics and gynecology international 2010 1687-9589 2010 [Refereed][Not invited]
  • Matsubara S, Ueda Y, Takahashi H, Nagai T, Kuwata T, Muto S, Yamaguchi T, Takizawa T, Suzuki M
    The journal of obstetrics and gynaecology research 35 (6) 1109 - 1114 1341-8076 2009/12 [Refereed][Not invited]
  • Watanabe N, Tsutsui J, Kakiuchi S, Jwa SC, Takahashi H, Kato N, Ozawa N, Sago H, Kitagawa M
    Obstetrics and gynecology international 2009 564567  1687-9589 2009 [Refereed][Not invited]
  • Hironori Takahashi, Hideo Matsuda, Yoshifumi Mizumoto, Kenichi Furuya
    JOURNAL OF PERINATAL MEDICINE 36 (2) 178 - 181 0300-5577 2008 [Refereed][Not invited]
  • H Matsuda, K Sakaguchi, T Shibasaki, H Takahashi, Y Kawakami, K Furuya
    JOURNAL OF PERINATAL MEDICINE 33 (6) 561 - 563 0300-5577 2005/12 [Refereed][Not invited]
     
    Parvovirus B19-infected hydrops fetalis was treated using gammaglobulin injection into the peritoneal cavity (GIFPeC) with B19-IgG-rich immunoglobulin. Fetal anemia and hydrops resolved, and B19-DNA in fetal ascites decreased despite no change in maternal B19-IgG or B19-DNA. Gammaglobulin injection into the peritoneal cavity is thus useful for treating hydrops fetalis while avoiding intrauterine blood-transfusion risks.
  • H Matsuda, K Sakaguchi, T Shibasaki, H Takahashi, Y Kawakami, K Furuya, Y Kikuchi
    JOURNAL OF PERINATAL MEDICINE 33 (3) 199 - 205 0300-5577 2005 [Refereed][Not invited]
     
    Objective: The aim of this study is to identify suitable applications for cerebral MR (magnetic resonance) scanning in cases of severe preeclampsia and eclampsia through comparison of clinical course and easily accessible parameters. Methods: From January 2001 to December 2003, cerebral MR scans were performed on 43 women with severe preeclampsia; of those 41 were enrolled in data analyses. Twenty clinical parameters, including age, body mass index, blood pressure, liver and renal function, and coagulation status, were compared for each patient. Data were analyzed using the SPSS program on a VAX main frame. Results: Among 41 severe preeclamptic women, abnormal MR images were observed in 11 cases including six with systemic seizures. Predictive accuracy of eclampsia with abnormal cerebral MR imaging was 84.9% (P=0.00001), while only 14.3% of severe preeclampsia cases had been diagnosed radiologically. Statistical analysis suggests diastolic BP and serum AST as predictive parameters for abnormal MR images with 82.9% predictive accuracy (P=0.0007). Conclusions: Cerebral edema can be observed in preeclamptic patients developing eclampsia. Rapid delivery is indicated when diastolic BID and AST are elevated. MR scanning is useful when delivery is delayed due to fetal immaturityin cases of severe preeclampsia.
  • Y Misawa, T Saito, H Konishi, S Oki, Y Kaminishi, Y Tezuka, K Aizawa, H Takahashi, N Hasegawa, O Kamisawa, M Kato, K Fuse
    ARTIFICIAL ORGANS 26 (10) 856 - 861 0160-564X 2002/10 [Refereed][Not invited]
     
    We analyzed midterm results using the Bicarbon valve in a single center. Forty-four patients had aortic valve replacement (AVR), 48 had mitral valve replacement (MVR), and 13 had both aortic and mitral valve replacement (DVR). The mean age of the 105 patients was 61.2+/-11.3 years. The mean follow-up was 1.8+/-1.1 years with a cumulative follow-up of 188 patient-years. There were 5 early deaths (4.7%: 4 in the AVR group and 1 in the MVR group) and 5 late deaths (2.7% per patient-year: 3 malignancy, 1 cerebral hemorrhage, 1 myocardial infarction). Survival at 3 years was 91+/-4% in the AVR group, 92+/-5% in the MVR group, and 66+/-23% in the DVR group. The linearized incidence of thromboembolic complications, hemorrhagic complications, and paravalvular leaks in all patients was 1.06+/-2.34%, 1.60+/-2.53%, and 0.53+/-2.22% per patient-year, respectively. No other complications were observed. In conclusion, the Bicarbon prosthetic heart valve has shown excellent clinical results associated with a low incidence of valve-related complications.

MISC

Awards & Honors

  • 2016/04 Japan Society of Obstetrics and Gynecology International Session Encouragement Award
     The differential expression of microRNA between human first trimester villous and extravillous trophoblast cells: PCR array-based approach 
    受賞者: Hironori Takahashi
  • 2015/04 Japan Society of Obstetrics and Gynecology Best Paper Award
     Extravillous trophoblast cell invasion is promoted by the CD44-hyaluronicacid interaction 
    受賞者: Hironori Takahashi
  • 2014/04 Japan Society of Obstetrics and Gynecology Award for excellence
     Regulatory mechanisms of CD44-mediated extravillous trophoblast cell invasion 
    受賞者: Hironori Takahashi
  • 2012/09 International Federation of Placenta Association YK Loke New Investigator Award
     CD44 accelerates trophoblastic invasion: in vitro invasion analysis using HTR8/SVneo cell 
    受賞者: Hironori Takahashi
  • 2008/06 日本産科婦人科学会関東連合地方部会 学術奨励賞
     胎児軽度脳室拡大の検討 
    受賞者: 高橋 宏典

Research Grants & Projects

  • Elucidation of the novel function of trophoblast DROSHA as a novel therapeutic strategy for preventing congenital viral infection
    Japan Society for the Promotion of Science:Grants-in-Aid for Scientific Research Grant-in-Aid for Scientific Research (C)
    Date (from‐to) : 2020/04 -2024/03 
    Author : 瀧澤 俊広, 大口 昭英, 高橋 宏典, 大倉 定之, 根岸 靖幸
  • 妊娠初期における超早産バイオマーカー探索:エクソソーム中胎盤特異的miRNA
    日本学術振興会:科学研究費助成事業 若手研究
    Date (from‐to) : 2019/04 -2022/03 
    Author : 高橋 宏典
     
    1.初期胎盤から抽出した絨毛外栄養膜、この細胞株(HTR8/SVneo、HChEpC1b)を用い、WNT3A、WNT5A、WNT10BがCD44を介して、当該細胞の浸潤を促進させていることを報告した(Takahashi H, et al. J Matern Fetal Neonatal Med, in press)。まず、第1三半期の胎盤においてWNT19種類のサブタイプのうちWNT3A、WNT5A、WNT10Bがいずれも発現が強かったことから、この分子に着目して、解析を進めた。絨毛外栄養膜においてもWNT3A、WNT5A、WNT10Bの発現を観察した。続いて、WNT3A、WNT5A、WNT10Bを絨毛外栄養膜に添加したところ、この細胞の浸潤及びCD44発現が増加した。さらに、WNTに対するsiRNAや拮抗薬を用いたところ、絨毛外栄養膜の浸潤やCD44発現は逆に減少した。結果、新たな絨毛膜栄養膜の浸潤を促進させる因子としてWNT3A、WNT5A、WNT10Bが存在することを示し、当該WNTはCD44を介して、浸潤を促進させることが示唆された。 2. 妊娠初期の早産予知因子同定のために、妊娠初期採血を回収し、約800例集積しえた。また約500例は分娩予後が判明し、この中で超早産例も発生しており、もう少し検体数が必要ではあるが、統計学的に許容される検体数がほぼ集積できている。 3.超早産例における胎盤および血液を集積した(5例)。
  • Japan Society for the Promotion of Science:Grants-in-Aid for Scientific Research Grant-in-Aid for Scientific Research (C)
    Date (from‐to) : 2016/04 -2019/03 
    Author : Takahashi Hironori, SHIRASUNA komei
     
    Early-onset preeclampsia (PE) induces very preterm delivery and, thus, the outcome of infants with early-onset PE is generally poor. Although the reasons of the etiology remain unknown, extravillous trophoblast (EVT) invasion disorder is speculated as the etiology. Here, the purpose of this study was to clarify (1) microRNA(miRNA)s associated with EVT invasion disorder and its mechanism, and (2) changes of miRNAs in maternal blood in early-onset PE. Three novelties were made: (1) placenta-associated miR-520c suppressed EVT invasion via exosome; (2) WNT10B is an accelerator of EVT invasion; (3) sixty miRNAs significantly change in maternal blood in patients with early-onset PE.


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