nagashima takao

FacultyInternalMedicineRheumatology&ClinicalImmunology
Job titleAssociate ProfessorWeb site

Profile

Research Keywords

    MRL-lpr, lpr, Fluvastatin

Research Areas

  • Clinical internal medicine / Collagenous pathology/Allergology/Infectious disease medicine

Research Activities

Papers(paper)

  • Reactivation of hepatitis B virus in rheumatoid arthritis patients treated with biological disease-modifying antirheumatic drugs.
    Nakamura J, Nagashima T, Nagatani K, Yoshio T, Iwamoto M, Minota S
    International journal of rheumatic diseases Apr. 2014
  • Invasive sphenoid sinus aspergillosis mimicking giant cell arteritis.
    Murosaki T, Nagashima T, Honne K, Aoki Y, Minota S
    International journal of rheumatic diseases Oct. 2013
  • Posterior ischemic optic neuropathy in a patient with granulomatosis with polyangiitis (Wegener's).
    Nagashima T, Matsumoto K, Murosaki T, Okada M, Iwamoto M, Makino S, Minota S
    Rheumatology international 33 1915-1916 Jul. 2013
  • Caution is needed when interpreting changes of matrix metalloproteinase-3 in patients with rheumatoid arthritis.
    Nagashima T, Minota S
    Rheumatology international Jul. 2013
  • Fluorodeoxyglucose positron emission tomography/computed tomography for diagnostic imaging in relapsing polychondritis with atypical manifestations.
    Honne K, Nagashima T, Onishi S, Nagatani K, Iwamoto M, Minota S
    Journal of clinical rheumatology : practical reports on rheumatic & musculoskeletal diseases 19 104-105 Mar. 2013
  • An unusual cause of hemichorea-hemiballism in a patient with systemic lupus erythematosus.
    Maruyama A, Nagashima T, Kamata Y, Nagatani K, Murosaki T, Yoshio T, Minota S
    Rheumatology international 33 267-268 Jan. 2013
  • Glucocorticoid-induced normotensive scleroderma renal crisis: a report on two cases and a review of the literature in Japan.
    Maruyama A, Nagashima T, Ikenoya K, Aoki Y, Matsuyama Y, Iwamoto M, Minota S
    Internal medicine (Tokyo, Japan) 52 1833-1837 2013
  • Radiographic features of rhupus arthropathy.
    Nakamura J, Nagashima T, Akiyama Y, Minota S
    Internal medicine (Tokyo, Japan) 52 2837 2013
  • Comment on "Comparison of MMP-3 levels in rheumatoid arthritis after treatment with tocilizumab or infliximab for 12 weeks" by Yokoe et al.
    Nagashima T, Okazaki H, Kamata Y, Minota S
    Modern rheumatology / the Japan Rheumatism Association 22 638-9; authoe reply 640 Aug. 2012
  • Unchanged serum viral load and liver function during tocilizumab treatment in a patient with rheumatoid arthritis and hepatitis C virus infection.
    Nagashima T, Maruyama A, Kamata Y, Minota S
    Rheumatology international 32 2231-2232 Jul. 2012
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Papers(paper)close
  • Reactivation of hepatitis B virus in rheumatoid arthritis patients treated with biological disease-modifying antirheumatic drugs.
    Nakamura J, Nagashima T, Nagatani K, Yoshio T, Iwamoto M, Minota S
    International journal of rheumatic diseases Apr. 2014
  • Invasive sphenoid sinus aspergillosis mimicking giant cell arteritis.
    Murosaki T, Nagashima T, Honne K, Aoki Y, Minota S
    International journal of rheumatic diseases Oct. 2013
  • Posterior ischemic optic neuropathy in a patient with granulomatosis with polyangiitis (Wegener's).
    Nagashima T, Matsumoto K, Murosaki T, Okada M, Iwamoto M, Makino S, Minota S
    Rheumatology international 33 1915-1916 Jul. 2013
  • Caution is needed when interpreting changes of matrix metalloproteinase-3 in patients with rheumatoid arthritis.
    Nagashima T, Minota S
    Rheumatology international Jul. 2013
  • Fluorodeoxyglucose positron emission tomography/computed tomography for diagnostic imaging in relapsing polychondritis with atypical manifestations.
    Honne K, Nagashima T, Onishi S, Nagatani K, Iwamoto M, Minota S
    Journal of clinical rheumatology : practical reports on rheumatic & musculoskeletal diseases 19 104-105 Mar. 2013
  • An unusual cause of hemichorea-hemiballism in a patient with systemic lupus erythematosus.
    Maruyama A, Nagashima T, Kamata Y, Nagatani K, Murosaki T, Yoshio T, Minota S
    Rheumatology international 33 267-268 Jan. 2013
  • Glucocorticoid-induced normotensive scleroderma renal crisis: a report on two cases and a review of the literature in Japan.
    Maruyama A, Nagashima T, Ikenoya K, Aoki Y, Matsuyama Y, Iwamoto M, Minota S
    Internal medicine (Tokyo, Japan) 52 1833-1837 2013
  • Radiographic features of rhupus arthropathy.
    Nakamura J, Nagashima T, Akiyama Y, Minota S
    Internal medicine (Tokyo, Japan) 52 2837 2013
  • Comment on "Comparison of MMP-3 levels in rheumatoid arthritis after treatment with tocilizumab or infliximab for 12 weeks" by Yokoe et al.
    Nagashima T, Okazaki H, Kamata Y, Minota S
    Modern rheumatology / the Japan Rheumatism Association 22 638-9; authoe reply 640 Aug. 2012
  • Unchanged serum viral load and liver function during tocilizumab treatment in a patient with rheumatoid arthritis and hepatitis C virus infection.
    Nagashima T, Maruyama A, Kamata Y, Minota S
    Rheumatology international 32 2231-2232 Jul. 2012
  • Subclinical Riedel's thyroiditis with hypothyroidism coexisting with Mikulicz's disease.
    Nagashima T, Maruyama A, Takatori S, Saito M, Osuga J, Minota S
    Rheumatology international 32 1851-1852 Jun. 2012
  • Sustained elevation of interleukin-33 in sera and synovial fluids from patients with rheumatoid arthritis non-responsive to anti-tumor necrosis factor: possible association with persistent IL-1β signaling and a poor clinical response.
    Matsuyama Y, Okazaki H, Hoshino M, Onishi S, Kamata Y, Nagatani K, Nagashima T, Iwamoto M, Yoshio T, Ohto-Ozaki H, Tamemoto H, Komine M, Sekiya H, Tominaga S, Minota S
    Rheumatology international 32 1397-1401 May 2012
  • Healthcare-associated infections in rheumatology in Japan.
    Iwamoto M, Kamimura T, Nagashima T, Kamata Y, Aoki Y, Onishi S, Minota S
    Rheumatology international 32 801-804 Mar. 2012
  • Comment on: Churg-Strauss syndrome: a retrospective study of 11 cases from a single center in Japan.
    Matsumoto K, Nagashima T, Iwamoto M, Minota S
    International journal of rheumatic diseases 15 e2-3 Feb. 2012
  • Interleukin-18 in adult-onset Still's disease: treatment target or disease activity indicator?
    Nagashima T, Iwamoto M, Matsumoto K, Minota S
    Internal medicine (Tokyo, Japan) 51 449; author reply 451 2012
  • Marked colonic wall thickening in lupus enteritis.
    Murosaki T, Nagashima T, Matsumoto K, Minota S
    Internal medicine (Tokyo, Japan) 51 1451 2012
  • Foot ulcers caused by rheumatoid vasculitis in a patient with rheumatoid arthritis undergoing etanercept treatment.
    Murosaki T, Nagashima T, Aoki Y, Imai Y, Iwamoto M, Minota S
    Internal medicine (Tokyo, Japan) 51 3181-3183 2012
  • Moderate incidence of prior rheumatoid arthritis in patients with polymyositis and dermatomyositis.
    Nagashima T, Iwamoto M, Minota S
    Clinical rheumatology 30 875-876 Jun. 2011
  • Antisynthetase syndrome associated with long-standing rheumatoid arthritis.
    Nagashima T, Iwamoto M, Minota S
    Rheumatology international 31 705-706 May 2011
  • Comment on: Usefulness of anti-cyclic citrullinated peptide antibody and rheumatoid factor to detect rheumatoid arthritis in patients with systemic sclerosis.
    Nagashima T, Minota S
    Rheumatology (Oxford, England) 50 994-996 May 2011
  • Dermatomyositis in patients with rheumatoid arthritis during adalimumab therapy.
    Nagashima T, Minota S
    The Journal of rheumatology 38 574; author reply 575 Mar. 2011
  • Successful treatment of a patient with rheumatoid arthritis and IgA-κ multiple myeloma with tocilizumab.
    Matsuyama Y, Nagashima T, Honne K, Kamata Y, Iwamoto M, Okazaki H, Sato K, Ozawa K, Minota S
    Internal medicine (Tokyo, Japan) 50 639-642 2011
  • Decrease in the levels of anti-cyclic citrullinated peptide antibody in Japanese patients with rheumatoid arthritis who responded to anti-tumor necrosis factor-α.
    Onishi S, Yoshio T, Nagashima T, Minota S
    Modern rheumatology / the Japan Rheumatism Association 20 528-530 Oct. 2010
  • Simultaneous pneumatosis cystoides intestinalis and pneumomediastinum in a patient with systemic sclerosis.
    Honne K, Maruyama A, Onishi S, Nagashima T, Minota S
    The Journal of rheumatology 37 2194-2195 Oct. 2010
  • Acute acalculous cholecystitis in systemic sclerosis.
    Nagashima T, Imai T, Matsumoto K, Onishi S, Takatori S, Iwamoto M, Minota S
    Rheumatology international 30 1549-1550 Sep. 2010
  • Is polymyositis or dermatomyositis in patients with rheumatoid arthritis induced or unveiled by anti-tumor necrosis factor treatment?
    Nagashima T, Minota S
    Clinical rheumatology 29 819-820 Jul. 2010
  • Tocilizumab for rheumatoid arthritis with chronic hepatitis B virus infection without antiviral therapy.
    Nagashima T, Minota S
    The Journal of rheumatology 37 1066; author reply 1067 May 2010
  • Autoimmune hepatitis and adult-onset Still's disease: can they coexist?
    Nagashima T, Minota S
    Clinical rheumatology 29 449-450 Apr. 2010
  • Increased levels of interleukin 33 in sera and synovial fluid from patients with active rheumatoid arthritis.
    Matsuyama Y, Okazaki H, Tamemoto H, Kimura H, Kamata Y, Nagatani K, Nagashima T, Hayakawa M, Iwamoto M, Yoshio T, Tominaga S, Minota S
    The Journal of rheumatology 37 18-25 Jan. 2010
  • Prognostic indicators related to death in patients with Pneumocystis pneumonia associated with collagen vascular diseases.
    Aoki Y, Iwamoto M, Kamata Y, Nagashima T, Yoshio T, Okazaki H, Minota S
    Rheumatology international 29 1327-1330 Sep. 2009
  • Destructive arthropathy associated with dermatomyositis sine myositis positive for anti-Jo-1 and anti-cyclic citrullinated peptide antibodies.
    Nagashima T, Sato H, Minota S
    The Journal of rheumatology 36 2133-2134 Sep. 2009
  • Dermatomyositis associated with thyroid cancer: a paraneoplastic syndrome?
    Nagashima T, Onishi S, Kamata Y, Minota S
    Rheumatology international 29 1261-1262 Aug. 2009
  • Protein-losing gastroenteropathy associated with primary Sjögren's syndrome: a characteristic oriental variant.
    Nagashima T, Hoshino M, Shimoji S, Morino N, Kamimura T, Okazaki H, Minota S
    Rheumatology international 29 817-820 May 2009
  • Pyoderma gangrenosum associated with Takayasu's arteritis without typical symptoms.
    Futaki K, Komine M, Hosoda S, Hirashima M, Yokokura H, Yamada T, Murata S, Matsuyama Y, Nagashima T, Nara H, Minota S, Ohtsuki M
    European journal of dermatology : EJD 19 266-267 May 2009
  • Glucocorticoid and cyclosporine refractory adult onset Still's disease successfully treated with tocilizumab.
    Matsumoto K, Nagashima T, Takatori S, Kawahara Y, Yagi M, Iwamoto M, Okazaki H, Minota S
    Clinical rheumatology 28 485-487 Apr. 2009
  • Steroid-refractory severe hepatic failure in adult onset Still's disease responding to cyclosporine.
    Nagashima T, Aoki Y, Onishi S, Iwamoto M, Okazaki H, Minota S
    Clinical rheumatology 27 1451-1453 Nov. 2008
  • Polyarthritis induced by nonepisodic angioedema associated with eosinophilia.
    Nagashima T, Matsumoto K, Yamamoto R, Iwamoto M, Minota S
    Rheumatology international 28 1065-1066 Aug. 2008
  • Increase in plasma levels of adiponectin after administration of anti-tumor necrosis factor agents in patients with rheumatoid arthritis.
    Nagashima T, Okubo-Fornbacher H, Aoki Y, Kamata Y, Kimura H, Kamimura T, Nara H, Iwamoto M, Yoshio T, Okazaki H, Minota S
    The Journal of rheumatology 35 936-938 May 2008
  • Marked pneumatosis cystoides intestinalis in a patient with mixed connective tissue disease.
    Aoki Y, Nagashima T, Kamimura T, Iwamoto M, Minota S
    The Journal of rheumatology 33 1705-1706 Aug. 2006
  • Images in cardiovascular medicine. Kimura's disease presenting as steroid-responsive thromboangiitis obliterans.
    Nagashima T, Kamimura T, Nara H, Iwamoto M, Okazaki H, Minota S
    Circulation 114 e10-1 Jul. 2006
  • Apoptosis of rheumatoid synovial cells by statins through the blocking of protein geranylgeranylation: a potential therapeutic approach to rheumatoid arthritis.
    Nagashima T, Okazaki H, Yudoh K, Matsuno H, Minota S
    Arthritis and rheumatism 54 579-586 Feb. 2006
  • Semiquantitative assessment of the intestinal motility in chronic intestinal pseudo-obstruction in systemic sclerosis and mixed connective tissue disease by Sitzmarks capsule.
    Nagashima T, Iwamoto M, Minota S
    Modern rheumatology / the Japan Rheumatism Association 16 330-331 2006
  • Marked dilatation of pulmonary arteries in mixed connective tissue disease.
    Nagashima T, Masuyama J, Okubo H, Minota S
    The Journal of rheumatology 32 1168-1169 Jun. 2005
  • [Immunomodulatory activities of statins].
    Okazaki H, Nagashima T, Minota S
    Nihon Rinsho Men'eki Gakkai kaishi = Japanese journal of clinical immunology 27 357-360 Dec. 2004
  • Elevated muscle enzymes in a patient with severe hypocalcemia mimicking polymyositis.
    Hirata D, Nagashima T, Saito S, Okazaki H, Kano S, Minota S
    Modern rheumatology / the Japan Rheumatism Association 12 186-189 Jun. 2002
  • Antineutrophil cytoplasmic autoantibody specific for proteinase 3 in a patient with shunt nephritis induced by Gemella morbillorum.
    Nagashima T, Hirata D, Yamamoto H, Okazaki H, Minota S
    American journal of kidney diseases : the official journal of the National Kidney Foundation 37 E38 May 2001

Papers(other)

  • Dramatic Improvement of Psoriatic Arthritis by Infliximab in a Patient Refractory to Conventional Therapy Presenting with Elevated Serum β-D-glucan
    Yasushi Matsuyama, Takao Nagashima, Tomokazu Masuda, Masahiro Iwamoto, Taku Yoshio, Hitoaki Okazaki, Mamitaro Ohtsuki, Seiji Minota
    Jichi Medical University journal 32 63-69 Mar. 2010
  • The incidence of infectious complications during admission and within 2 months after discharge in patients with systemic lupus erythematosus treated with high dose glucocorticoids
    Aoki Yoko, Iwamoto Masahiro, Kimura Hirotaka, Nagashima Takao, Yoshio Taku, Okazaki Hitoaki, Minota Seiji
    Jichi Medical University journal 30 29-36 Dec. 2007
  • Deep vein thrombosis in inpatients
    Kamata Yasuyuki, Iwamoto Masahiro, Aoki Youko, Nagashima Takao, Nara Hiroyuki, Kamimura Takeshi, Yoshio Taku, Okazaki Hitoaki, Minota Seiji
    Jichi Medical University journal 29 163-167 Dec. 2006
  • Immunomodulatory activities of statins
    OKAZAKI Hitoaki, NAGASHIMA Takao, MINOTA Seiji
    Japanese Journal of Clinical Immunology 27(6) 357-360 Dec. 2004
  • Rapidly Progressed Secondary Amyloidosis in a Patient with Still's Disease with γ-allele in His SAA 1 Gene
    KANEKO Naoko, MIMORI Akio, BABA Satoshi, NARA Hiroyuki, SHIROTA Yuko, NAGASHIMA Takao, HIRATA Daisuke, YOSHIO Taku, OKAZAKI Hitoaki, KANO Shogo, MINOTA Seiji
    40(3) 633-638 Jul. 2000
Display all
Papers(other)close
  • Dramatic Improvement of Psoriatic Arthritis by Infliximab in a Patient Refractory to Conventional Therapy Presenting with Elevated Serum β-D-glucan
    Yasushi Matsuyama, Takao Nagashima, Tomokazu Masuda, Masahiro Iwamoto, Taku Yoshio, Hitoaki Okazaki, Mamitaro Ohtsuki, Seiji Minota
    Jichi Medical University journal 32 63-69 Mar. 2010
  • The incidence of infectious complications during admission and within 2 months after discharge in patients with systemic lupus erythematosus treated with high dose glucocorticoids
    Aoki Yoko, Iwamoto Masahiro, Kimura Hirotaka, Nagashima Takao, Yoshio Taku, Okazaki Hitoaki, Minota Seiji
    Jichi Medical University journal 30 29-36 Dec. 2007
  • Deep vein thrombosis in inpatients
    Kamata Yasuyuki, Iwamoto Masahiro, Aoki Youko, Nagashima Takao, Nara Hiroyuki, Kamimura Takeshi, Yoshio Taku, Okazaki Hitoaki, Minota Seiji
    Jichi Medical University journal 29 163-167 Dec. 2006
  • Immunomodulatory activities of statins
    OKAZAKI Hitoaki, NAGASHIMA Takao, MINOTA Seiji
    Japanese Journal of Clinical Immunology 27(6) 357-360 Dec. 2004
  • Rapidly Progressed Secondary Amyloidosis in a Patient with Still's Disease with γ-allele in His SAA 1 Gene
    KANEKO Naoko, MIMORI Akio, BABA Satoshi, NARA Hiroyuki, SHIROTA Yuko, NAGASHIMA Takao, HIRATA Daisuke, YOSHIO Taku, OKAZAKI Hitoaki, KANO Shogo, MINOTA Seiji
    40(3) 633-638 Jul. 2000


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