iwamoto Sadahiko

FacultyDivisionofHumanGenetics
Job titleProfessorWeb site

Profile

Research Keywords

    Human Genetics, Polygenic diseases, Population Genetics, Genetic epidemiology, Forensic medicine

Research Areas

  • Genome science / Basic genome science
  • Basic medicine / Human genetics

Career

  • Jichi Medical University, Professor
  • Apr.2011
    -
    Today
    Jichi Medical University Division of Human Genetics, Center for Molecular Medicine, Professor
  • Apr.2004
    -
    Mar.2011
    Jichi Medical University Division of Human Genetics, Center for Community Medicine, Professor
  • Apr.2003
    -
    Mar.2004
    Jichi Medical University Legal Medicine and Human Genetics, Professor
  • Feb.1996
    -
    Mar.2003
    Jichi Medical University Legal Medicine and Human Genetics, Associate Professor
  • Apr.1992
    -
    Jan.1996
    Jichi Medical University Legal Medicine and Human Genetics, Lecturer
  • Apr.1991
    -
    Mar.1992
    Jichi Medical University Legal Medicine and Human Genetics, Associate Professor

Research Activities

Papers(other)

  • TRIB1 downregulates hepatic lipogenesis and glycogenesis via multiple molecular interactions.
    Ishizuka Y, Nakayama K, Ogawa A, Makishima S, Boonvisut S, Hirao A, Iwasaki Y, Yada T, Yanagisawa Y, Miyashita H, Takahashi M, Iwamoto S
    J Mol Endocrinol. 52 145-158 Feb. 2014
  • A single nucleotide polymorphism in the FADS1/FADS2 gene is associated with plasma lipid profiles in two genetically similar Asian ethnic groups with distinctive differences in lifestyle.
    Nakayama K, Bayasgalan T, Tazoe F, Yanagisawa Y, Gotoh T, Yamanaka K, Ogawa A, Munkhtulga L, Chimedregze U, Kagawa Y, Ishibashi S, Iwamoto S
    Hum Genet. 127 685-690 Jun. 2010
  • Regulatory SNP in the RBP4 Gene Modified the Expression in Adipocytes and Associated With BMI.
    Munkhtulga L, Nakayama K, Utsumi N, Yanagisawa Y, Gotoh T, Omi T, Kumada M, Erdenebulgan B, Zolzaya K, Lkhagvasuren T, Iwamoto S.
    Obesity (Silver Spring). 18 1006-1014 May 2010
  • Large scale replication analysis of loci associated with lipid concentrations in a Japanese population.
    Nakayama K, Bayasgalan T, Yamanaka K, Kumada M, Gotoh T, Utsumi N, Yanagisawa Y, Okayama M, Kajii E, Ishibashi S, Iwamoto S
    J Med Genet. 46 370-374 Jun. 2009
  • Genetic heterogeneity in a susceptible region for essential hypertension among demographically different local populations in Japan.
    Kumada M, Lkhagvasuren M, Utsumi N, Omi T, Gotoh T, Kamesaki T, Okuda H, Kajii E, Iwamoto S.
    Community Genet. 11 150-159 2008
  • Identification of a regulatory SNP in the retinol binding protein 4 gene associated with type 2 diabetes in Mongolia.
    Munkhtulga L, Nakayama K, Utsumi N, Yanagisawa Y, Gotoh T, Omi T, Kumada M, Erdenebulgan B, Zolzaya K, Lkhagvasuren T, Iwamoto S.
    Hum Genet. 120 879-888 Feb. 2007
  • An intronic variable number of tandem repeat polymorphisms of the cold-induced autoinflammatory syndrome 1 (CIAS1) gene modifies gene expression and is associated with essential hypertension.
    Omi T, Kumada M, Kamesaki T, Okuda H, Munkhtulga L, Yanagisawa Y, Utsumi N, Gotoh T, Hata A, Soma M, Umemura S, Ogihara T, Takahashi N, Tabara Y, Shimada K, Mano H, Kajii E, Miki T, Iwamoto S.
    Eur J Hum Genet. 14 1295-1305 Dec. 2006
  • Aly/ REF, a factor for mRNA transport, activates RH gene promoter function.
    Suganuma H, Kumada M, Omi T, Gotoh T, Lkhagvasuren M, Okuda H, Kamesaki T, Kajii E, Iwamoto S.
    FEBS J. 272 2696-2704 Jun. 2005
  • DNA-based identification resolved suspected misdiagnosis due to contaminated cytological specimens.
    Iwamoto S, Kamesaki T, Kumada M, Omi T, Okuda H, Hasegawa T, Sakurai S, Kajii E.
    Leg Med (Tokyo). 5 246-250 Dec. 2003
  • Rat encodes the paralogous gene equivalent of the human histo-blood group ABO gene. Association with antigen expression by overexpression of human ABO transferase.
    Iwamoto S, Kumada M, Kamesaki T, Okuda H, Kajii E, Inagaki T, Saikawa D, Takeuchi K, Ohkawara S, Takahashi R, Ueda S, Inoue S, Tahara K, Hakamata Y, Kobayashi E.
    J Biol Chem. 277 46463-46469 Nov. 2002
Display all
Papers(other)close
  • TRIB1 downregulates hepatic lipogenesis and glycogenesis via multiple molecular interactions.
    Ishizuka Y, Nakayama K, Ogawa A, Makishima S, Boonvisut S, Hirao A, Iwasaki Y, Yada T, Yanagisawa Y, Miyashita H, Takahashi M, Iwamoto S
    J Mol Endocrinol. 52 145-158 Feb. 2014
  • A single nucleotide polymorphism in the FADS1/FADS2 gene is associated with plasma lipid profiles in two genetically similar Asian ethnic groups with distinctive differences in lifestyle.
    Nakayama K, Bayasgalan T, Tazoe F, Yanagisawa Y, Gotoh T, Yamanaka K, Ogawa A, Munkhtulga L, Chimedregze U, Kagawa Y, Ishibashi S, Iwamoto S
    Hum Genet. 127 685-690 Jun. 2010
  • Regulatory SNP in the RBP4 Gene Modified the Expression in Adipocytes and Associated With BMI.
    Munkhtulga L, Nakayama K, Utsumi N, Yanagisawa Y, Gotoh T, Omi T, Kumada M, Erdenebulgan B, Zolzaya K, Lkhagvasuren T, Iwamoto S.
    Obesity (Silver Spring). 18 1006-1014 May 2010
  • Large scale replication analysis of loci associated with lipid concentrations in a Japanese population.
    Nakayama K, Bayasgalan T, Yamanaka K, Kumada M, Gotoh T, Utsumi N, Yanagisawa Y, Okayama M, Kajii E, Ishibashi S, Iwamoto S
    J Med Genet. 46 370-374 Jun. 2009
  • Genetic heterogeneity in a susceptible region for essential hypertension among demographically different local populations in Japan.
    Kumada M, Lkhagvasuren M, Utsumi N, Omi T, Gotoh T, Kamesaki T, Okuda H, Kajii E, Iwamoto S.
    Community Genet. 11 150-159 2008
  • Identification of a regulatory SNP in the retinol binding protein 4 gene associated with type 2 diabetes in Mongolia.
    Munkhtulga L, Nakayama K, Utsumi N, Yanagisawa Y, Gotoh T, Omi T, Kumada M, Erdenebulgan B, Zolzaya K, Lkhagvasuren T, Iwamoto S.
    Hum Genet. 120 879-888 Feb. 2007
  • An intronic variable number of tandem repeat polymorphisms of the cold-induced autoinflammatory syndrome 1 (CIAS1) gene modifies gene expression and is associated with essential hypertension.
    Omi T, Kumada M, Kamesaki T, Okuda H, Munkhtulga L, Yanagisawa Y, Utsumi N, Gotoh T, Hata A, Soma M, Umemura S, Ogihara T, Takahashi N, Tabara Y, Shimada K, Mano H, Kajii E, Miki T, Iwamoto S.
    Eur J Hum Genet. 14 1295-1305 Dec. 2006
  • Aly/ REF, a factor for mRNA transport, activates RH gene promoter function.
    Suganuma H, Kumada M, Omi T, Gotoh T, Lkhagvasuren M, Okuda H, Kamesaki T, Kajii E, Iwamoto S.
    FEBS J. 272 2696-2704 Jun. 2005
  • DNA-based identification resolved suspected misdiagnosis due to contaminated cytological specimens.
    Iwamoto S, Kamesaki T, Kumada M, Omi T, Okuda H, Hasegawa T, Sakurai S, Kajii E.
    Leg Med (Tokyo). 5 246-250 Dec. 2003
  • Rat encodes the paralogous gene equivalent of the human histo-blood group ABO gene. Association with antigen expression by overexpression of human ABO transferase.
    Iwamoto S, Kumada M, Kamesaki T, Okuda H, Kajii E, Inagaki T, Saikawa D, Takeuchi K, Ohkawara S, Takahashi R, Ueda S, Inoue S, Tahara K, Hakamata Y, Kobayashi E.
    J Biol Chem. 277 46463-46469 Nov. 2002
  • Reactivity of autoantibodies of autoimmune hemolytic anemia with recombinant rhesus blood group antigens or anion transporter band3.
    Iwamoto S, Kamesaki T, Oyamada T, Okuda H, Kumada M, Omi T, Takahashi J, Tani Y, Omine M, Kajii E.
    Am J Hematol. 68 106-114 Oct. 2001
  • Cloning and characterization of erythroid-specific DNase I-hypersensitive site in human rhesus-associated glycoprotein gene
    The Journal of Biological Chemistry 275 27324-27331 2000
  • Deletion of A-antigen in a human cancer cell live is associated with reduced promoter activity of CBF/NF-Y binding region, and possibly with enhanced DNA methylation of A transterase promoter
    Iwamoto S, Withers DA, Handa K, Hakomori S
    Glycoconjugate Journal 16(10) 659-666 1999
  • Expression Analysis of human rhesus blood group antiagens by gene transduction into erythroid and non-enythroid cells.
    Iwamoto S, Yamasaki M, Kawano M, Okuda H, Omi T, Takahashi J, Tani Y, Omine M, Kajii E
    International Journal of Hematology 68(3) 257-268 1998
  • Identification of 5'flanking sequence of RH50 gene and the core region for erythroid-specific expression.
    Iwamoto S, Omi T, Yamasaki M, Okuda H, Kawano M, Kajii E
    Biochemical and Biophysical Research Communications. 243(1) 233-240 1998
  • Characterization of the Duffy gene promotor : evidence for tissue-specific abolishment of expression in Fy(a-b-) of black individuals
    S.Iwamoto, J.Li, N.Sugimoto, H.Okuda, E.Kajii
    Biochemical and Biophysical Research Communications 222(3) 852-859 1996
  • Identification of a novel exon and spliced from of Duffy mRNA that is the predominant transcript in both erythroid and postcapillary venule endothelium.
    S.Iwamoto, J.Li, T.Omi, S.Ikemoto, E.Kajii
    Blood 87(1) 378-385 1996
  • Genomic Organization of the Glycoprotein D Gene : Duffy Blood Group Fya/Fyb Alloantigen System Is Associated With a Polymorphism at the 44-Amino Acid Residue
    S.Iwamoto, T.Omi, E.Kajii, S.Ikemoto
    Blood, 85(3) 622-626 1995
  • An Exon 28 Mutation Resulting in Alternative Splicing of the Glycoprotein IIb Transcript and Glanzmann's Thrombasthenia.
    S.Iwamoto, E.Nishiumi, E.Kajii, S.Ikemoto
    Blood 83(4) 1017-1023 1994
  • Point mutation in the band 4.2 gene associated with autosomal recessively inherited erythrocyte band 4.2 deficiency.
    S.Iwamoto, E.Kajii, T.Omi, T.Kamesaki, Y.Akifuji, S.Ikemoto
    Eur J Haematol 50 286-291 1993
  • Characterization of a 28-kD polymorphic polypeptide detected by two-dimensional electrophoresis of human platelets.
    S.Iwamoto, E.Kajii, T.Omi, S.Tsuchida, S.Ikemoto
    Hum Hered 42 276-279 1992

Conference Presentations

  • TRIB1 is involved in the susceptibility of non-alcoholic fatty liver disease.
    Iwamoto S, Ishizuka Y, Kitamura Y, Makishima S, Boonvisut S, Nakayama K
    62nd Annual Meeting of American Society of Human Genetics 09 Nov. 2012
Display all
Conference Presentationsclose
  • TRIB1 is involved in the susceptibility of non-alcoholic fatty liver disease.
    Iwamoto S, Ishizuka Y, Kitamura Y, Makishima S, Boonvisut S, Nakayama K
    62nd Annual Meeting of American Society of Human Genetics 09 Nov. 2012

Outside Fund Adoption

  • Genetics of polygenic diseases
    :Cooperative Research
    Project Year :2003 - 2008
  • Molecular genetics of blood group antigens
    :Funded Research
    Project Year :1992
  • Genetic polymorphism and life style oriented diseases
Display all
Outside Fund Adoptionclose
  • Genetics of polygenic diseases
    :Cooperative Research
    Project Year :2003 - 2008
  • Molecular genetics of blood group antigens
    :Funded Research
    Project Year :1992
  • Genetic polymorphism and life style oriented diseases

Works

  • Characterization of 28KD polymorphic polypeptide detected by two-dimensional electrophoresis of human platelets.
    1991
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Worksclose
  • Characterization of 28KD polymorphic polypeptide detected by two-dimensional electrophoresis of human platelets.
    1991


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