yanagisawa ken

FacultyDepartmentofBiochemistry,DivisionofStructuralBiochemistry
Job titleProfessorWeb site

Profile

Research Keywords

    ST2L, IL-1 receptor family, contact inhibition

Research Areas

  • Biological science / Molecular biology
  • Basic medicine / General medical chemistry

Research Activities

Papers(paper)

  • ST2 gene products critically contribute to cellular transformation caused by an oncogenic Ras mutant.
    Tago K, Ohta S, Kashiwada M, Funakoshi-Tago M, Matsugi J, Tominaga SI, Yanagisawa K
    Heliyon 3(10) e00436 Oct. 2017
  • STAT3 and ERK pathways are involved in cell growth stimulation of the ST2/IL1RL1 promoter.
    Tago K, Ohta S, Funakoshi-Tago M, Aoki-Ohmura C, Matsugi J, Tominaga SI, Yanagisawa K
    FEBS open bio 7(2) 293-302 Feb. 2017
  • ARIH2 Ubiquitinates NLRP3 and Negatively Regulates NLRP3 Inflammasome Activation in Macrophages.
    Kawashima A, Karasawa T, Tago K, Kimura H, Kamata R, Usui-Kawanishi F, Watanabe S, Ohta S, Funakoshi-Tago M, Yanagisawa K, Kasahara T, Suzuki K, Takahashi M.
    J Immunol 199(10) 3614-3622 2017
  • Intracellular NF-HEV/IL-33 harbors essential roles in Ras-induced cellular transformation by contributing to cyclin D1 protein synthesis.
    Ohta S, Tago K, Funakoshi-Tago M, Matsugi J, Yanagisawa K
    Cellular signalling 28(8) 1025-1036 Aug. 2016
  • Anti-inflammatory activity of flavonoids in Nepalese propolis is attributed to inhibition of the IL-33 signaling pathway.
    Funakoshi-Tago M, Okamoto K, Izumi R, Tago K, Yanagisawa K, Narukawa Y, Kiuchi F, Kasahara T, Tamura H
    International immunopharmacology 25(1) 189-198 Mar. 2015
  • NLRP3 regulates neutrophil functions and contributes to hepatic ischemia-reperfusion injury independently of inflammasomes.
    Inoue Y, Shirasuna K, Kimura H, Usui F, Kawashima A, Karasawa T, Tago K, Dezaki K, Nishimura S, Sagara J, Noda T, Iwakura Y, Tsutsui H, Taniguchi S, Yanagisawa K, Yada T, Yasuda Y, Takahashi M
    Journal of immunology (Baltimore, Md. : 1950) 192(9) 4342-4351 May 2014
  • Presence of a novel exon 2E encoding a putative transmembrane protein in human IL-33 gene.
    Tominaga S, Hayakawa M, Tsuda H, Ohta S, Yanagisawa K
    Biochemical and biophysical research communications 430(3) 969-974 Jan. 2013
  • YM-175 induces apoptosis of human native monocyte-lineage cells via inhibition of prenylation.
    Miwa A, Takezako N, Hayakawa H, Hayakawa M, Tominaga S, Yanagisawa K
    American journal of hematology 87(12) 1084-1088 Dec. 2012
  • Soluble ST2 protein inhibits LPS stimulation on monocyte-derived dendritic cells.
    Nagata A, Takezako N, Tamemoto H, Ohto-Ozaki H, Ohta S, Tominaga S, Yanagisawa K
    Cellular & molecular immunology 9(5) 399-409 Sep. 2012
  • ST2 gene expression is proliferation-dependent and its ligand, IL-33, induces inflammatory reaction in endothelial cells.
    Aoki S, Hayakawa M, Ozaki H, Takezako N, Obata H, Ibaraki N, Tsuru T, Tominaga S, Yanagisawa K
    Molecular and cellular biochemistry 335(1-2) 75-81 Feb. 2010
Display all
Papers(paper)close
  • ST2 gene products critically contribute to cellular transformation caused by an oncogenic Ras mutant.
    Tago K, Ohta S, Kashiwada M, Funakoshi-Tago M, Matsugi J, Tominaga SI, Yanagisawa K
    Heliyon 3(10) e00436 Oct. 2017
  • STAT3 and ERK pathways are involved in cell growth stimulation of the ST2/IL1RL1 promoter.
    Tago K, Ohta S, Funakoshi-Tago M, Aoki-Ohmura C, Matsugi J, Tominaga SI, Yanagisawa K
    FEBS open bio 7(2) 293-302 Feb. 2017
  • ARIH2 Ubiquitinates NLRP3 and Negatively Regulates NLRP3 Inflammasome Activation in Macrophages.
    Kawashima A, Karasawa T, Tago K, Kimura H, Kamata R, Usui-Kawanishi F, Watanabe S, Ohta S, Funakoshi-Tago M, Yanagisawa K, Kasahara T, Suzuki K, Takahashi M.
    J Immunol 199(10) 3614-3622 2017
  • Intracellular NF-HEV/IL-33 harbors essential roles in Ras-induced cellular transformation by contributing to cyclin D1 protein synthesis.
    Ohta S, Tago K, Funakoshi-Tago M, Matsugi J, Yanagisawa K
    Cellular signalling 28(8) 1025-1036 Aug. 2016
  • Anti-inflammatory activity of flavonoids in Nepalese propolis is attributed to inhibition of the IL-33 signaling pathway.
    Funakoshi-Tago M, Okamoto K, Izumi R, Tago K, Yanagisawa K, Narukawa Y, Kiuchi F, Kasahara T, Tamura H
    International immunopharmacology 25(1) 189-198 Mar. 2015
  • NLRP3 regulates neutrophil functions and contributes to hepatic ischemia-reperfusion injury independently of inflammasomes.
    Inoue Y, Shirasuna K, Kimura H, Usui F, Kawashima A, Karasawa T, Tago K, Dezaki K, Nishimura S, Sagara J, Noda T, Iwakura Y, Tsutsui H, Taniguchi S, Yanagisawa K, Yada T, Yasuda Y, Takahashi M
    Journal of immunology (Baltimore, Md. : 1950) 192(9) 4342-4351 May 2014
  • Presence of a novel exon 2E encoding a putative transmembrane protein in human IL-33 gene.
    Tominaga S, Hayakawa M, Tsuda H, Ohta S, Yanagisawa K
    Biochemical and biophysical research communications 430(3) 969-974 Jan. 2013
  • YM-175 induces apoptosis of human native monocyte-lineage cells via inhibition of prenylation.
    Miwa A, Takezako N, Hayakawa H, Hayakawa M, Tominaga S, Yanagisawa K
    American journal of hematology 87(12) 1084-1088 Dec. 2012
  • Soluble ST2 protein inhibits LPS stimulation on monocyte-derived dendritic cells.
    Nagata A, Takezako N, Tamemoto H, Ohto-Ozaki H, Ohta S, Tominaga S, Yanagisawa K
    Cellular & molecular immunology 9(5) 399-409 Sep. 2012
  • ST2 gene expression is proliferation-dependent and its ligand, IL-33, induces inflammatory reaction in endothelial cells.
    Aoki S, Hayakawa M, Ozaki H, Takezako N, Obata H, Ibaraki N, Tsuru T, Tominaga S, Yanagisawa K
    Molecular and cellular biochemistry 335(1-2) 75-81 Feb. 2010
  • ST2 suppresses IL-6 production via the inhibition of IkappaB degradation induced by the LPS signal in THP-1 cells.
    Takezako N, Hayakawa M, Hayakawa H, Aoki S, Yanagisawa K, Endo H, Tominaga S
    Biochemical and biophysical research communications 341(2) 425-432 Mar. 2006
  • Functional SNPs in the distal promoter of the ST2 gene are associated with atopic dermatitis.
    Shimizu M, Matsuda A, Yanagisawa K, Hirota T, Akahoshi M, Inomata N, Ebe K, Tanaka K, Sugiura H, Nakashima K, Tamari M, Takahashi N, Obara K, Enomoto T, Okayama Y, Gao PS, Huang SK, Tominaga S, Ikezawa Z, Shirakawa T
    Human molecular genetics 14(19) 2919-2927 Oct. 2005
  • T-helper type 2 cell-specific expression of the ST2 gene is regulated by transcription factor GATA-3.
    Hayakawa M, Yanagisawa K, Aoki S, Hayakawa H, Takezako N, Tominaga S
    Biochimica et biophysica acta 1728(1-2) 53-64 Apr. 2005
  • Molecular cloning of the chicken ST2 gene and a novel variant form of the ST2 gene product, ST2LV.
    Iwahana H, Hayakawa M, Kuroiwa K, Tago K, Yanagisawa K, Noji S, Tominaga S
    Biochimica et biophysica acta 1681(1) 1-14 Nov. 2004
  • A novel splice variant of mouse interleukin-1-receptor-associated kinase-1 (IRAK-1) activates nuclear factor-kappaB (NF-kappaB) and c-Jun N-terminal kinase (JNK).
    Yanagisawa K, Tago K, Hayakawa M, Ohki M, Iwahana H, Tominaga S
    The Biochemical journal 370(Pt 1) 159-166 Feb. 2003
  • Opposite regulation of the expression of cyclin-dependent kinase inhibitors during contact inhibition.
    Yanagisawa K, Kosaka A, Iwahana H, Nakanishi M, Tominaga S.
    J Biochem 125(1) 36-40 1999
  • Studies on natural ST2 gene products in the human leukemic cell line UT-7 using monoclonal antihuman ST2 antibodies.
    Yoshida K, Arai T, Yokota T, Komatsu N, Miura Y, Yanagisawa K, Tetsuka T, Tominaga S.
    Hybridoma 14(5) 419-427 1995
  • The existence of a growth-specific DNA binding factor for the promoter region of mouse ST2 gene.
    Tominaga S, Kato-Yamazaki M, Yanagisawa K, Kawakami K, Tetsuka T.
    FEBS Lett 354(3) 311-314 1994
  • Guanosine diphosphatase is required for protein and sphingolipid glycosylation in the Golgi lumen of Saccharomyces cerevisiae.
    Abeijon C, Yanagisawa K, Mandon EC, Häusler A, Moremen K, Hirschberg CB, Robbins PW.
    J Cell Biol 122(2) 307-323 1993
  • Presence of a novel primary response gene ST2L, encoding a product highly similar to the interleukin 1 receptor type 1.
    Yanagisawa K, Takagi T, Tsukamoto T, Tetsuka T, Tominaga S.
    FEBS Lett 318(1) 83-87 1993
  • Identification of the product of the murine ST2 gene.
    Takagi T, Yanagisawa K, Tsukamoto T, Tetsuka T, Nagata S, Tominaga S.
    Biochim Biophys Acta 1178(2) 194-200 1993
  • Different factors bind to the regulatory region of the Na+,K(+)-ATPase alpha 1-subunit gene during the cell cycle.
    Kawakami K, Yanagisawa K, Watanabe Y, Tominaga S, Nagano K.
    FEBS Lett 335(2) 251-254 1993
  • Nucleotide sequence of a complementary DNA for human ST2.
    Tominaga S, Yokota T, Yanagisawa K, Tsukamoto T, Takagi T, Tetsuka T.
    Biochim Biophys Acta 1171(2) 215-218 1992
  • Murine ST2 gene is a member of the primary response gene family induced by growth factors.
    Yanagisawa K, Tsukamoto T, Takagi T, Tominaga S.
    FEBS Lett 302(1) 51-53 1992
  • A guanosine diphosphatase enriched in Golgi vesicles of Saccharomyces cerevisiae. Purification and characterization.
    Yanagisawa K, Resnick D, Abeijon C, Robbins PW, Hirschberg CB.
    J Biol Chem 265(31) 19351-19355 1990
  • Purification and properties of GM2 synthase, UDP-N-acetylgalactosamine: GM3 beta-N-acetylgalactosaminyltransferase from rat liver.
    Yanagisawa K, Taniguchi N, Makita A.
    Biochim Biophys Acta 919(3) 213-220 1987
  • Purification and properties of rat liver globotriaosylceramide synthase, UDP-galactose:lactosylceramide alpha 1-4-galactosyltransferase.
    Taniguchi N, Yanagisawa K, Makita A, Naiki M.
    J Biol Chem 260(8) 4908-4913 1985
  • Globoside and Forssman synthases in human lymphocytes exposed to Epstein-Barr virus and mitogens.
    Taniguchi N, Yanagisawa K, Makita A, Mizuno F, Osato T.
    J Natl Cancer Inst 74(3) 563-568 1985
  • Glycosphingolipids of equine erythrocytes membranes: complete characterization of a fucoganglioside.
    Gasa S, Makita A, Yanagisawa K, Nakamura M.
    Adv Exp Med Biol 174 111-117 1984
  • The effect of ST2 gene product on achorage-independent growth of a glioblastoma cell line, T98G.
    Eur.J.Biochem. 270(1) 163-170 2003
  • ST2 protein induced by inflammatory stimuli can modulate acute lung inflammation.
    Biochem. Biophys. Res. Commun. 299, 18-24 2002
  • Expression and function of the ST2 gene in a murine model of allergic airway inflammation.
    Clin. Exp. Allergy 32 (10), 1520-1526 2002
  • Expression of ST2 in Helper T Lymphocytes of Malignant Pleural Effusions
    Am. J. Resp. Crit. Care Med. 165 (7), 1005-1009 2002
  • Tissue distribution and subcellular localization of a variant form of the human ST2 gene product, ST2V.
    Biochem. Biophys. Res. Commun. 285 (5), 1377-1383 2001
  • Presence of a genistein-responsive inhibitory mechanism on interleukin-1a-induced NF-kB activation.
    Eur. J. Biochem 268 (24), 6526-6533 2001
  • Elevated soluble ST2 protein levels in sera of asthma patients with an acute exacerbation.
    Am. J. Resp. Crit. Care Med. 164 (2), 277-281 2001
  • The cloning and nucleotide sequence of human ST2L CDNA.
    Genomics 67(3) 284-290 2000
  • Construction of ELISA system to quantify human ST2 protein in sera of patients. (共著)
    Hybridoma 19(151-159) 2000
  • Effects of long-term administration of erythromycin on cytobine production in rat alveolar macrophages. (共著)
    Eur. Respir. J. 14 1113-1116 1999
  • Presence and expression of a novel variant form of ST2 geve product in human loubenic cell live UT-7/GM. (共著)
    Biochem. Biophys. Res. Commun. 264(1) 14-18 1999
  • Primary expression of vascular endothelial growth factor geve in growth-stimulated BALB/c-3T3 cells. (共著)
    Jichi Med. School J. 22 87-94 1999
  • Different promoter usage and multiple transcription initiation sites of the interkeukin-1 receptor-related human ST2 gene in UT-7 and TM12 cells. (共著)
    Eur. J. Biochem. 264(2) 397-406 1999
  • CMP-NeuAC : Galβ1-4 GlcNAc 92-6 Sialyltransferase catalyzes NeuAc transfer to glycolipids.
    Journal of Lipid Research 38(9) 1795-1806 1997
  • The expression of ST2 gene in helper Tcells and the binding of ST2 protein to myeloma-derived RPMI8226 cells.
    J. Biochemistry(Tokyo) 121(1) 95-103 1997
  • A novel splice variant of mouse interleukin-1 receptor-associated kinase-1 (IRAK-1) activates nuclear factor kB (NF-kB) and c-Jun N-terminal kinase (JNK).
    Biochem. J. in press

Papers(other)

  • 自然免疫と臨床疾患 ST2遺伝子と病気
    富永 眞一, 早川 裕子, 早川 盛禎, 柳沢 健
    補体シンポジウム講演集 45 89-89 Jul. 2008
  • IL-1のシグナル伝達系におけるIRAK1-Sの機能
    柳沢 健, 早川 盛禎, 富永 眞一
    生化学 74(8) 930-930 Aug. 2002
  • ニワトリST2遺伝子のゲノム構造とその発現について
    岩花 弘之, 早川 盛禎, 多胡 憲治, 柳沢 健, 富永 眞一
    生化学 73(8) 1056-1056 Aug. 2001
  • マウスT細胞におけるST2遺伝子の発現調節
    早川 盛禎, 柳沢 健, 多胡 憲治, 岩花 弘之, 富永 眞一
    生化学 73(8) 706-706 Aug. 2001
  • IRAK-1の選択的スプライシングバリアントの発現と機能
    柳沢 健, 多胡 憲治, 早川 盛禎, 岩花 弘之, 富永 眞一
    生化学 73(8) 731-731 Aug. 2001
  • ST2LV:ST2遺伝子産物の新しいバリアントについて
    岩花 弘之, 早川 盛禎, 柳沢 健, 多胡 憲治, 黒岩 憲二, 芳賀 靖, 増沢 紀男, 野地 澄晴, 冨永 眞一
    生化学 72(8) 1031-1031 Aug. 2000
  • ST2の新規splicing variant,ST2Vは細胞膜表面に局在する
    多胡 憲治, 黒岩 憲二, 李 紅杰, 柳沢 健, 岩花 弘之, 富永 眞一
    生化学 72(8) 1030-1030 Aug. 2000
  • 増殖刺激時のBALB/c-3T3細胞における血管内皮細胞増殖因子のprimary responseによる発現
    柳沢 健, 黒岩 憲二, 多胡 憲治, 岩花 弘之, 内田 広夫, 富永 眞一
    自治医科大学紀要 22 87-94 Dec. 1999
  • 【T細胞機能と細胞内分子】 ST2遺伝子産物とhelper T細胞
    柳沢 健, 富永 眞一
    臨床免疫 32(5) 513-517 Nov. 1999
  • ヒト膜在型ST2 cDNAのクローニングと組織における発現
    李 紅杰, 柳沢 健, 黒岩 憲二, 多胡 憲治, 岩花 弘之, 新井 孝夫, 富永 眞一
    生化学 71(8) 1058-1058 Aug. 1999
Display all
Papers(other)close
  • 自然免疫と臨床疾患 ST2遺伝子と病気
    富永 眞一, 早川 裕子, 早川 盛禎, 柳沢 健
    補体シンポジウム講演集 45 89-89 Jul. 2008
  • IL-1のシグナル伝達系におけるIRAK1-Sの機能
    柳沢 健, 早川 盛禎, 富永 眞一
    生化学 74(8) 930-930 Aug. 2002
  • ニワトリST2遺伝子のゲノム構造とその発現について
    岩花 弘之, 早川 盛禎, 多胡 憲治, 柳沢 健, 富永 眞一
    生化学 73(8) 1056-1056 Aug. 2001
  • マウスT細胞におけるST2遺伝子の発現調節
    早川 盛禎, 柳沢 健, 多胡 憲治, 岩花 弘之, 富永 眞一
    生化学 73(8) 706-706 Aug. 2001
  • IRAK-1の選択的スプライシングバリアントの発現と機能
    柳沢 健, 多胡 憲治, 早川 盛禎, 岩花 弘之, 富永 眞一
    生化学 73(8) 731-731 Aug. 2001
  • ST2LV:ST2遺伝子産物の新しいバリアントについて
    岩花 弘之, 早川 盛禎, 柳沢 健, 多胡 憲治, 黒岩 憲二, 芳賀 靖, 増沢 紀男, 野地 澄晴, 冨永 眞一
    生化学 72(8) 1031-1031 Aug. 2000
  • ST2の新規splicing variant,ST2Vは細胞膜表面に局在する
    多胡 憲治, 黒岩 憲二, 李 紅杰, 柳沢 健, 岩花 弘之, 富永 眞一
    生化学 72(8) 1030-1030 Aug. 2000
  • 増殖刺激時のBALB/c-3T3細胞における血管内皮細胞増殖因子のprimary responseによる発現
    柳沢 健, 黒岩 憲二, 多胡 憲治, 岩花 弘之, 内田 広夫, 富永 眞一
    自治医科大学紀要 22 87-94 Dec. 1999
  • 【T細胞機能と細胞内分子】 ST2遺伝子産物とhelper T細胞
    柳沢 健, 富永 眞一
    臨床免疫 32(5) 513-517 Nov. 1999
  • ヒト膜在型ST2 cDNAのクローニングと組織における発現
    李 紅杰, 柳沢 健, 黒岩 憲二, 多胡 憲治, 岩花 弘之, 新井 孝夫, 富永 眞一
    生化学 71(8) 1058-1058 Aug. 1999
  • ニワトリST2遺伝子の胎生期における発現
    岩花 弘之, 柳沢 健, 多胡 憲治, 黒岩 憲二, 芳賀 靖, 増沢 紀男, 野地 澄晴, 富永 眞一
    生化学 71(8) 942-942 Aug. 1999
  • Donor Specific Transfusion(DST)による免疫寛容誘導のメカニズム(I) alpha-2 macroglobulinの同定とその免疫抑制効果
    内田 広夫, 小林 英司, 鬼頭 康彦, 水田 耕一, 藤村 昭夫, 河原崎 秀雄, 橋都 浩平, 柳沢 健, 富永 眞一
    移植 33(総会臨時) 163-163 Oct. 1998
  • ヒトST2遺伝子の2つのプロモーターの細胞株による使い分け
    岩花 弘之, 柳沢 健, 小坂 明子, 黒岩 憲二, 小松 則夫, 富永 眞一
    生化学 70(8) 1077-1077 Aug. 1998
  • マウス線維芽細胞BALB/c-3T3におけるVEGFの発現様式
    柳沢 健, 多胡 憲治, 岩花 弘之, 富永 眞一
    生化学 70(8) 977-977 Aug. 1998
  • 接触阻止へのCyclin dependent kinase inhibitorsの関与
    柳沢 健
    生化学 69(7) 734-734 Jul. 1997
  • 血液系細胞,特にヘルパーT細胞におけるST2(L)(IL-1受容体類似orphan receptor)の発現
    柳沢 健
    生化学 67(7) 779-779 Jul. 1995
  • IL-1受容体類似のorphan receptor,ST2Lに関する研究
    柳沢 健
    生化学 66(7) 991-991 Jul. 1994
  • 受容体型ST 2;細胞増殖開始過程で特異的に発現されるIL-1受容体類似のcDNAのクローニング
    柳沢 健
    生化学 64(8) 904-904 Aug. 1992
  • 細胞増殖開始過程におけるマウスST2遺伝子の発現様式
    柳沢 健
    生化学 63(8) 744-744 Aug. 1991
  • ラット寒天肉芽腫大顆粒画分の蛋白質生合成について
    柳沢 健
    生化学 59(8) 941-941 Aug. 1987
  • ガングリオシドGM2合成酵素(UDP-N-アセチルガラクトサミン:GM3β1→4N-アセチルガラクトサミン転移酵素)の精製と諸性質
    柳沢 健
    北海道医学雑誌 60(5) 662-670 Sep. 1985
  • Ganglioside GM2合成酵素(UDP-GalNAc, GM3, B1→4:N-アセチルガラクトサミン転移酵素)の精製と諸性質
    柳沢 健
    生化学 56(9) 1204-1204 Sep. 1984
  • Ganglioside GM2合成酵素(UDP-Gal NAc:GM3 β 1→4 Gal NAc転移酵素)の精製と諸性質
    柳沢 健
    生化学 56(8) 871-871 Aug. 1984
  • Experimental small bowel transplantation using a newborn intestine in rats : (]G0002[). revasculatization of newborn intestine is independent of vascular endotherial growth factor. (共著)
    J. Pediatr. surg. 34(9) 1396-1400 1999
  • The role of nucleotides in the glycoconjugate metabohism ; transport and metabolism of sugar-nucleotides.
    Protein Nucleic Acid Enzyme 37(11) 1992

Outside Fund Adoption

  • Biological function of ST2L, an orphan receptor which shows high similarity with IL-1 receptor type I.
  • The role of cyclin despendent Kinase inhibitors in contact inhibition
Display all
Outside Fund Adoptionclose
  • Biological function of ST2L, an orphan receptor which shows high similarity with IL-1 receptor type I.
  • The role of cyclin despendent Kinase inhibitors in contact inhibition


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