yanagisawa ken

FacultyDepartmentofBiochemistry,DivisionofStructuralBiochemistry
Job titleProfessorWeb site

Profile

Research Keywords

    ST2L, IL-1 receptor family, contact inhibition

Research Areas

  • Biological science / Molecular biology
  • Basic medicine / General medical chemistry

Research Activities

Papers(paper)

  • ST2 gene products critically contribute to cellular transformation caused by an oncogenic Ras mutant.
    Tago K, Ohta S, Kashiwada M, Funakoshi-Tago M, Matsugi J, Tominaga SI, Yanagisawa K
    Heliyon 3(10) e00436 Oct. 2017
  • STAT3 and ERK pathways are involved in cell growth stimulation of the ST2/IL1RL1 promoter.
    Tago K, Ohta S, Funakoshi-Tago M, Aoki-Ohmura C, Matsugi J, Tominaga SI, Yanagisawa K
    FEBS open bio 7(2) 293-302 Feb. 2017
  • ARIH2 Ubiquitinates NLRP3 and Negatively Regulates NLRP3 Inflammasome Activation in Macrophages.
    Kawashima A, Karasawa T, Tago K, Kimura H, Kamata R, Usui-Kawanishi F, Watanabe S, Ohta S, Funakoshi-Tago M, Yanagisawa K, Kasahara T, Suzuki K, Takahashi M.
    J Immunol 199(10) 3614-3622 2017
  • Intracellular NF-HEV/IL-33 harbors essential roles in Ras-induced cellular transformation by contributing to cyclin D1 protein synthesis.
    Ohta S, Tago K, Funakoshi-Tago M, Matsugi J, Yanagisawa K
    Cellular signalling 28(8) 1025-1036 Aug. 2016
  • Anti-inflammatory activity of flavonoids in Nepalese propolis is attributed to inhibition of the IL-33 signaling pathway.
    Funakoshi-Tago M, Okamoto K, Izumi R, Tago K, Yanagisawa K, Narukawa Y, Kiuchi F, Kasahara T, Tamura H
    International immunopharmacology 25(1) 189-198 Mar. 2015
  • NLRP3 regulates neutrophil functions and contributes to hepatic ischemia-reperfusion injury independently of inflammasomes.
    Inoue Y, Shirasuna K, Kimura H, Usui F, Kawashima A, Karasawa T, Tago K, Dezaki K, Nishimura S, Sagara J, Noda T, Iwakura Y, Tsutsui H, Taniguchi S, Yanagisawa K, Yada T, Yasuda Y, Takahashi M
    Journal of immunology (Baltimore, Md. : 1950) 192(9) 4342-4351 May 2014
  • Presence of a novel exon 2E encoding a putative transmembrane protein in human IL-33 gene.
    Tominaga S, Hayakawa M, Tsuda H, Ohta S, Yanagisawa K
    Biochemical and biophysical research communications 430(3) 969-974 Jan. 2013
  • YM-175 induces apoptosis of human native monocyte-lineage cells via inhibition of prenylation.
    Miwa A, Takezako N, Hayakawa H, Hayakawa M, Tominaga S, Yanagisawa K
    American journal of hematology 87(12) 1084-1088 Dec. 2012
  • Soluble ST2 protein inhibits LPS stimulation on monocyte-derived dendritic cells.
    Nagata A, Takezako N, Tamemoto H, Ohto-Ozaki H, Ohta S, Tominaga S, Yanagisawa K
    Cellular & molecular immunology 9(5) 399-409 Sep. 2012
  • ST2 gene expression is proliferation-dependent and its ligand, IL-33, induces inflammatory reaction in endothelial cells.
    Aoki S, Hayakawa M, Ozaki H, Takezako N, Obata H, Ibaraki N, Tsuru T, Tominaga S, Yanagisawa K
    Molecular and cellular biochemistry 335(1-2) 75-81 Feb. 2010
Display all
Papers(paper)close
  • ST2 gene products critically contribute to cellular transformation caused by an oncogenic Ras mutant.
    Tago K, Ohta S, Kashiwada M, Funakoshi-Tago M, Matsugi J, Tominaga SI, Yanagisawa K
    Heliyon 3(10) e00436 Oct. 2017
  • STAT3 and ERK pathways are involved in cell growth stimulation of the ST2/IL1RL1 promoter.
    Tago K, Ohta S, Funakoshi-Tago M, Aoki-Ohmura C, Matsugi J, Tominaga SI, Yanagisawa K
    FEBS open bio 7(2) 293-302 Feb. 2017
  • ARIH2 Ubiquitinates NLRP3 and Negatively Regulates NLRP3 Inflammasome Activation in Macrophages.
    Kawashima A, Karasawa T, Tago K, Kimura H, Kamata R, Usui-Kawanishi F, Watanabe S, Ohta S, Funakoshi-Tago M, Yanagisawa K, Kasahara T, Suzuki K, Takahashi M.
    J Immunol 199(10) 3614-3622 2017
  • Intracellular NF-HEV/IL-33 harbors essential roles in Ras-induced cellular transformation by contributing to cyclin D1 protein synthesis.
    Ohta S, Tago K, Funakoshi-Tago M, Matsugi J, Yanagisawa K
    Cellular signalling 28(8) 1025-1036 Aug. 2016
  • Anti-inflammatory activity of flavonoids in Nepalese propolis is attributed to inhibition of the IL-33 signaling pathway.
    Funakoshi-Tago M, Okamoto K, Izumi R, Tago K, Yanagisawa K, Narukawa Y, Kiuchi F, Kasahara T, Tamura H
    International immunopharmacology 25(1) 189-198 Mar. 2015
  • NLRP3 regulates neutrophil functions and contributes to hepatic ischemia-reperfusion injury independently of inflammasomes.
    Inoue Y, Shirasuna K, Kimura H, Usui F, Kawashima A, Karasawa T, Tago K, Dezaki K, Nishimura S, Sagara J, Noda T, Iwakura Y, Tsutsui H, Taniguchi S, Yanagisawa K, Yada T, Yasuda Y, Takahashi M
    Journal of immunology (Baltimore, Md. : 1950) 192(9) 4342-4351 May 2014
  • Presence of a novel exon 2E encoding a putative transmembrane protein in human IL-33 gene.
    Tominaga S, Hayakawa M, Tsuda H, Ohta S, Yanagisawa K
    Biochemical and biophysical research communications 430(3) 969-974 Jan. 2013
  • YM-175 induces apoptosis of human native monocyte-lineage cells via inhibition of prenylation.
    Miwa A, Takezako N, Hayakawa H, Hayakawa M, Tominaga S, Yanagisawa K
    American journal of hematology 87(12) 1084-1088 Dec. 2012
  • Soluble ST2 protein inhibits LPS stimulation on monocyte-derived dendritic cells.
    Nagata A, Takezako N, Tamemoto H, Ohto-Ozaki H, Ohta S, Tominaga S, Yanagisawa K
    Cellular & molecular immunology 9(5) 399-409 Sep. 2012
  • ST2 gene expression is proliferation-dependent and its ligand, IL-33, induces inflammatory reaction in endothelial cells.
    Aoki S, Hayakawa M, Ozaki H, Takezako N, Obata H, Ibaraki N, Tsuru T, Tominaga S, Yanagisawa K
    Molecular and cellular biochemistry 335(1-2) 75-81 Feb. 2010
  • ST2 suppresses IL-6 production via the inhibition of IkappaB degradation induced by the LPS signal in THP-1 cells.
    Takezako N, Hayakawa M, Hayakawa H, Aoki S, Yanagisawa K, Endo H, Tominaga S
    Biochemical and biophysical research communications 341(2) 425-432 Mar. 2006
  • Functional SNPs in the distal promoter of the ST2 gene are associated with atopic dermatitis.
    Shimizu M, Matsuda A, Yanagisawa K, Hirota T, Akahoshi M, Inomata N, Ebe K, Tanaka K, Sugiura H, Nakashima K, Tamari M, Takahashi N, Obara K, Enomoto T, Okayama Y, Gao PS, Huang SK, Tominaga S, Ikezawa Z, Shirakawa T
    Human molecular genetics 14(19) 2919-2927 Oct. 2005
  • T-helper type 2 cell-specific expression of the ST2 gene is regulated by transcription factor GATA-3.
    Hayakawa M, Yanagisawa K, Aoki S, Hayakawa H, Takezako N, Tominaga S
    Biochimica et biophysica acta 1728(1-2) 53-64 Apr. 2005
  • Molecular cloning of the chicken ST2 gene and a novel variant form of the ST2 gene product, ST2LV.
    Iwahana H, Hayakawa M, Kuroiwa K, Tago K, Yanagisawa K, Noji S, Tominaga S
    Biochimica et biophysica acta 1681(1) 1-14 Nov. 2004
  • A novel splice variant of mouse interleukin-1-receptor-associated kinase-1 (IRAK-1) activates nuclear factor-kappaB (NF-kappaB) and c-Jun N-terminal kinase (JNK).
    Yanagisawa K, Tago K, Hayakawa M, Ohki M, Iwahana H, Tominaga S
    The Biochemical journal 370(Pt 1) 159-166 Feb. 2003
  • Opposite regulation of the expression of cyclin-dependent kinase inhibitors during contact inhibition.
    Yanagisawa K, Kosaka A, Iwahana H, Nakanishi M, Tominaga S.
    J Biochem 125(1) 36-40 1999
  • Presence of a novel primary response gene ST2L, encoding a product highly similar to the interleukin 1 receptor type 1.
    Yanagisawa K, Takagi T, Tsukamoto T, Tetsuka T, Tominaga S.
    FEBS Lett 318(1) 83-87 1993
  • Guanosine diphosphatase is required for protein and sphingolipid glycosylation in the Golgi lumen of Saccharomyces cerevisiae.
    Abeijon C, Yanagisawa K, Mandon EC, Häusler A, Moremen K, Hirschberg CB, Robbins PW.
    J Cell Biol 122(2) 307-323 1993
  • Murine ST2 gene is a member of the primary response gene family induced by growth factors.
    Yanagisawa K, Tsukamoto T, Takagi T, Tominaga S.
    FEBS Lett 302(1) 51-53 1992
  • A guanosine diphosphatase enriched in Golgi vesicles of Saccharomyces cerevisiae. Purification and characterization.
    Yanagisawa K, Resnick D, Abeijon C, Robbins PW, Hirschberg CB.
    J Biol Chem 265(31) 19351-19355 1990
  • Purification and properties of GM2 synthase, UDP-N-acetylgalactosamine: GM3 beta-N-acetylgalactosaminyltransferase from rat liver.
    Yanagisawa K, Taniguchi N, Makita A.
    Biochim Biophys Acta 919(3) 213-220 1987
  • Globoside and Forssman synthases in human lymphocytes exposed to Epstein-Barr virus and mitogens.
    Taniguchi N, Yanagisawa K, Makita A, Mizuno F, Osato T.
    J Natl Cancer Inst 74(3) 563-568 1985
  • Purification and properties of rat liver globotriaosylceramide synthase, UDP-galactose:lactosylceramide alpha 1-4-galactosyltransferase.
    Taniguchi N, Yanagisawa K, Makita A, Naiki M.
    J Biol Chem 260(8) 4908-4913 1985
  • Glycosphingolipids of equine erythrocytes membranes: complete characterization of a fucoganglioside.
    Gasa S, Makita A, Yanagisawa K, Nakamura M.
    Adv Exp Med Biol 174 111-117 1984
  • Nucleotide sequence of a complementary DNA for human ST2.
    Tominaga S, Yokota T, Yanagisawa K, Tsukamoto T, Takagi T, Tetsuka T.
    Biochim Biophys Acta 1171(2) 215-218 1982
  • The effect of ST2 gene product on anchorage-independent growth of a glioblastoma cell line, T98G.
    Haga Y, Yanagisawa K, Ohto-Ozaki H, Tominaga S, Masuzawa T, Iwahana H.
    Eur J Biochem 270(1) 163-170 2003

Papers(other)

  • A Guanosine Diphosphatase Enriched in Golgi Vesicles of Saccharomyces cerevisiae ; Purification and Characterization. (共著)
    Journal of Biological Chemistry 265(31) 1990
  • Murine ST2 gene is a member of the prinary response gene family induced by growth factors.
    FEBS Letter 302(1) 51-53 1992
  • Purification and Properties of GM2 synthase, UDP-N-acetylgalactosamine : GM3 β-N-acetylgalactosaminyltransferase from rat liver
    Biochimica et Biophysica Acta 919 1987
  • The role of nucleotides in the glycoconjugate metabohism ; transport and metabolism of sugar-nucleotides.
    Protein Nucleic Acid Enzyme 37(11) 1992
  • Guanosine Diphosphatase is required for protein and sphingolipid glycosylation in the Golgi lumen of Saccharomyces cerevisiae. (共著)
    Journal of Cell Biology 122(2) 307-323 1993
  • Presence of a novel primary response gene ST2L, encoding a product highly similar to the interleukin 1 receptor type I. (共著)
    FEBS Letter 318(1) 83-87 1993
  • Identification of the product of the murine ST2 gene. (共著)
    Biochimica et Biophysica Acta 1178,194-200 1993
  • Different factors bind to the regulatory region of the Na+, K+-ATPase α1-subunit gene during the cell cycle. (共著)
    FEBS Letter 335,251-254 1993
  • The existence of a growth-specific DNA binding factor for the promoter region of mouse ST2 gene.(共著)
    FEBS Letter 354(3) 311-314 1994
  • Studies on natural ST2 gene products in the human leukemic cell line UT-7 using monoclonal antihuman ST2 antibodies.(共著)
    Hybridoma 14(5) 419-427 1995
Display all
Papers(other)close
  • A Guanosine Diphosphatase Enriched in Golgi Vesicles of Saccharomyces cerevisiae ; Purification and Characterization. (共著)
    Journal of Biological Chemistry 265(31) 1990
  • Murine ST2 gene is a member of the prinary response gene family induced by growth factors.
    FEBS Letter 302(1) 51-53 1992
  • Purification and Properties of GM2 synthase, UDP-N-acetylgalactosamine : GM3 β-N-acetylgalactosaminyltransferase from rat liver
    Biochimica et Biophysica Acta 919 1987
  • The role of nucleotides in the glycoconjugate metabohism ; transport and metabolism of sugar-nucleotides.
    Protein Nucleic Acid Enzyme 37(11) 1992
  • Guanosine Diphosphatase is required for protein and sphingolipid glycosylation in the Golgi lumen of Saccharomyces cerevisiae. (共著)
    Journal of Cell Biology 122(2) 307-323 1993
  • Presence of a novel primary response gene ST2L, encoding a product highly similar to the interleukin 1 receptor type I. (共著)
    FEBS Letter 318(1) 83-87 1993
  • Identification of the product of the murine ST2 gene. (共著)
    Biochimica et Biophysica Acta 1178,194-200 1993
  • Different factors bind to the regulatory region of the Na+, K+-ATPase α1-subunit gene during the cell cycle. (共著)
    FEBS Letter 335,251-254 1993
  • The existence of a growth-specific DNA binding factor for the promoter region of mouse ST2 gene.(共著)
    FEBS Letter 354(3) 311-314 1994
  • Studies on natural ST2 gene products in the human leukemic cell line UT-7 using monoclonal antihuman ST2 antibodies.(共著)
    Hybridoma 14(5) 419-427 1995
  • The expression of ST2 gene in helper Tcells and the binding of ST2 protein to myeloma-derived RPMI8226 cells.
    J. Biochemistry(Tokyo) 121(1) 95-103 1997
  • CMP-NeuAC : Galβ1-4 GlcNAc 92-6 Sialyltransferase catalyzes NeuAc transfer to glycolipids.
    Journal of Lipid Research 38(9) 1795-1806 1997
  • Opposite regulations of the expression of cyclin-dependent Kinase inhibitors during contact inhibition. (共著)
    J. Biochem. 125(1) 36-40 1999
  • Different promoter usage and multiple transcription initiation sites of the interkeukin-1 receptor-related human ST2 gene in UT-7 and TM12 cells. (共著)
    Eur. J. Biochem. 264(2) 397-406 1999
  • Experimental small bowel transplantation using a newborn intestine in rats : (]G0002[). revasculatization of newborn intestine is independent of vascular endotherial growth factor. (共著)
    J. Pediatr. surg. 34(9) 1396-1400 1999
  • Primary expression of vascular endothelial growth factor geve in growth-stimulated BALB/c-3T3 cells. (共著)
    Jichi Med. School J. 22 87-94 1999
  • Presence and expression of a novel variant form of ST2 geve product in human loubenic cell live UT-7/GM. (共著)
    Biochem. Biophys. Res. Commun. 264(1) 14-18 1999
  • Effects of long-term administration of erythromycin on cytobine production in rat alveolar macrophages. (共著)
    Eur. Respir. J. 14 1113-1116 1999
  • Construction of ELISA system to quantify human ST2 protein in sera of patients. (共著)
    Hybridoma 19(151-159) 2000
  • The cloning and nucleotide sequence of human ST2L CDNA.
    Genomics 67(3) 284-290 2000
  • Elevated soluble ST2 protein levels in sera of asthma patients with an acute exacerbation.
    Am. J. Resp. Crit. Care Med. 164 (2), 277-281 2001
  • Presence of a genistein-responsive inhibitory mechanism on interleukin-1a-induced NF-kB activation.
    Eur. J. Biochem 268 (24), 6526-6533 2001
  • Tissue distribution and subcellular localization of a variant form of the human ST2 gene product, ST2V.
    Biochem. Biophys. Res. Commun. 285 (5), 1377-1383 2001
  • Expression of ST2 in Helper T Lymphocytes of Malignant Pleural Effusions
    Am. J. Resp. Crit. Care Med. 165 (7), 1005-1009 2002
  • Expression and function of the ST2 gene in a murine model of allergic airway inflammation.
    Clin. Exp. Allergy 32 (10), 1520-1526 2002
  • ST2 protein induced by inflammatory stimuli can modulate acute lung inflammation.
    Biochem. Biophys. Res. Commun. 299, 18-24 2002
  • A novel splice variant of mouse interleukin-1 receptor-associated kinase-1 (IRAK-1) activates nuclear factor kB (NF-kB) and c-Jun N-terminal kinase (JNK).
    Biochem. J. in press
  • The effect of ST2 gene product on achorage-independent growth of a glioblastoma cell line, T98G.
    Eur.J.Biochem. 270(1) 163-170 2003

Outside Fund Adoption

  • Biological function of ST2L, an orphan receptor which shows high similarity with IL-1 receptor type I.
  • The role of cyclin despendent Kinase inhibitors in contact inhibition
Display all
Outside Fund Adoptionclose
  • Biological function of ST2L, an orphan receptor which shows high similarity with IL-1 receptor type I.
  • The role of cyclin despendent Kinase inhibitors in contact inhibition


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