iwasaki yuusaku

FacultyPhysiologyIntegrativePhysiology
Job titleAssistant ProfessorWeb site

Profile

Research Keywords

    GLP-1, nodose ganglion, CART

Research Areas

  • Basic medicine / General physiology
  • Agricultural chemistry / Food science

Research Activities

Papers(paper)

  • Peripheral oxytocin activates vagal afferent neurons to suppress feeding in normal and leptin-resistant mice: a route for ameliorating hyperphagia and obesity.
    Iwasaki Y, Maejima Y, Suyama S, Yoshida M, Arai T, Katsurada K, Kumari P, Nakabayashi H, Kakei M, Yada T
    American journal of physiology. Regulatory, integrative and comparative physiology 308(5) R360-9 Mar. 2015
  • Glucagon directly interacts with vagal afferent nodose ganglion neurons to induce Ca(2+) signaling via glucagon receptors.
    Ayush EA*, Iwasaki Y*, Iwamoto S, Nakabayashi H, Kakei M, Yada T (*Equally contributed)
    Biochemical and biophysical research communications 456(3) 727-732 Jan. 2015
  • Endogenous GLP-1 acts on paraventricular nucleus to suppress feeding: projection from nucleus tractus solitarius and activation of corticotropin-releasing hormone, nesfatin-1 and oxytocin neurons.
    Katsurada K, Maejima Y, Nakata M, Kodaira M, Suyama S, Iwasaki Y, Kario K, Yada T
    Biochemical and biophysical research communications 451(2) 276-281 Aug. 2014
  • TRIB1 downregulates hepatic lipogenesis and glycogenesis via multiple molecular interactions.
    Ishizuka Y, Nakayama K, Ogawa A, Makishima S, Boonvisut S, Hirao A, Iwasaki Y, Yada T, Yanagisawa Y, Miyashita H, Takahashi M, Iwamoto S, Jichi Medical University Promotion Team of Large-Scale Human Genome Bank for All over Japan
    Journal of molecular endocrinology 52(2) 145-158 Apr. 2014
  • Pancreatic polypeptide and peptide YY3-36 induce Ca2+ signaling in nodose ganglion neurons.
    Iwasaki Y, Kakei M, Nakabayashi H, Ayush EA, Hirano-Kodaira M, Maejima Y, Yada T
    Neuropeptides 47(1) 19-23 Feb. 2013
  • Bupropion can close KATP channel and induce insulin secretion.
    Yang Y, Shimomura K, Sakuma K, Maejima Y, Iwasaki Y, Galvanovskis J, Dezaki K, Nakata M, Yada T
    Journal of pediatric endocrinology & metabolism : JPEM 26(3-4) 343-346 2013
  • Insulin Activates Vagal Afferent Neurons Including those Innervating Pancreas via Insulin Cascade and Ca2+ Influx: Its Dysfunction in IRS2-KO Mice with Hyperphagic Obesity.
    Iwasaki Y, Shimomura K, Kohno D, Dezaki K, Ayush EA, Nakabayashi H, Kubota N, Kadowaki T, Kakei M, Nakata M, Yada T
    PloS one 8(6) e67198 2013
  • Vagal afferents sense meal-associated gastrointestinal and pancreatic hormones: mechanism and physiological role.
    Iwasaki Y, Yada T
    Neuropeptides 46(6) 291-297 Dec. 2012
  • Ingestion of cinnamaldehyde, a TRPA1 agonist, reduces visceral fats in mice fed a high-fat and high-sucrose diet.
    Tamura Y, Iwasaki Y, Narukawa M, Watanabe T
    Journal of nutritional science and vitaminology 58(1) 9-13 2012
  • Peripheral oxytocin treatment ameliorates obesity by reducing food intake and visceral fat mass.
    Maejima Y, Iwasaki Y, Yamahara Y, Kodaira M, Sedbazar U, Yada T
    Aging 3(12) 1169-1177 Dec. 2011
Display all
Papers(paper)close
  • Peripheral oxytocin activates vagal afferent neurons to suppress feeding in normal and leptin-resistant mice: a route for ameliorating hyperphagia and obesity.
    Iwasaki Y, Maejima Y, Suyama S, Yoshida M, Arai T, Katsurada K, Kumari P, Nakabayashi H, Kakei M, Yada T
    American journal of physiology. Regulatory, integrative and comparative physiology 308(5) R360-9 Mar. 2015
  • Glucagon directly interacts with vagal afferent nodose ganglion neurons to induce Ca(2+) signaling via glucagon receptors.
    Ayush EA*, Iwasaki Y*, Iwamoto S, Nakabayashi H, Kakei M, Yada T (*Equally contributed)
    Biochemical and biophysical research communications 456(3) 727-732 Jan. 2015
  • Endogenous GLP-1 acts on paraventricular nucleus to suppress feeding: projection from nucleus tractus solitarius and activation of corticotropin-releasing hormone, nesfatin-1 and oxytocin neurons.
    Katsurada K, Maejima Y, Nakata M, Kodaira M, Suyama S, Iwasaki Y, Kario K, Yada T
    Biochemical and biophysical research communications 451(2) 276-281 Aug. 2014
  • TRIB1 downregulates hepatic lipogenesis and glycogenesis via multiple molecular interactions.
    Ishizuka Y, Nakayama K, Ogawa A, Makishima S, Boonvisut S, Hirao A, Iwasaki Y, Yada T, Yanagisawa Y, Miyashita H, Takahashi M, Iwamoto S, Jichi Medical University Promotion Team of Large-Scale Human Genome Bank for All over Japan
    Journal of molecular endocrinology 52(2) 145-158 Apr. 2014
  • Pancreatic polypeptide and peptide YY3-36 induce Ca2+ signaling in nodose ganglion neurons.
    Iwasaki Y, Kakei M, Nakabayashi H, Ayush EA, Hirano-Kodaira M, Maejima Y, Yada T
    Neuropeptides 47(1) 19-23 Feb. 2013
  • Bupropion can close KATP channel and induce insulin secretion.
    Yang Y, Shimomura K, Sakuma K, Maejima Y, Iwasaki Y, Galvanovskis J, Dezaki K, Nakata M, Yada T
    Journal of pediatric endocrinology & metabolism : JPEM 26(3-4) 343-346 2013
  • Insulin Activates Vagal Afferent Neurons Including those Innervating Pancreas via Insulin Cascade and Ca2+ Influx: Its Dysfunction in IRS2-KO Mice with Hyperphagic Obesity.
    Iwasaki Y, Shimomura K, Kohno D, Dezaki K, Ayush EA, Nakabayashi H, Kubota N, Kadowaki T, Kakei M, Nakata M, Yada T
    PloS one 8(6) e67198 2013
  • Vagal afferents sense meal-associated gastrointestinal and pancreatic hormones: mechanism and physiological role.
    Iwasaki Y, Yada T
    Neuropeptides 46(6) 291-297 Dec. 2012
  • Ingestion of cinnamaldehyde, a TRPA1 agonist, reduces visceral fats in mice fed a high-fat and high-sucrose diet.
    Tamura Y, Iwasaki Y, Narukawa M, Watanabe T
    Journal of nutritional science and vitaminology 58(1) 9-13 2012
  • Peripheral oxytocin treatment ameliorates obesity by reducing food intake and visceral fat mass.
    Maejima Y, Iwasaki Y, Yamahara Y, Kodaira M, Sedbazar U, Yada T
    Aging 3(12) 1169-1177 Dec. 2011
  • Insulin suppresses ghrelin-induced calcium signaling in neuropeptide Y neurons of the hypothalamic arcuate nucleus.
    Maejima Y, Kohno D, Iwasaki Y, Yada T
    Aging 3(11) 1092-1097 Nov. 2011
  • TRPV1 agonist monoacylglycerol increases UCP1 content in brown adipose tissue and suppresses accumulation of visceral fat in mice fed a high-fat and high-sucrose diet.
    Iwasaki Y, Tamura Y, Inayoshi K, Narukawa M, Kobata K, Chiba H, Muraki E, Tsunoda N, Watanabe T
    Bioscience, biotechnology, and biochemistry 75(5) 904-909 2011
  • Stressor-responsive central nesfatin-1 activates corticotropin-releasing hormone, noradrenaline and serotonin neurons and evokes hypothalamic-pituitary-adrenal axis.
    Yoshida N, Maejima Y, Sedbazar U, Ando A, Kurita H, Damdindorj B, Takano E, Gantulga D, Iwasaki Y, Kurashina T, Onaka T, Dezaki K, Nakata M, Mori M, Yada T
    Aging 2(11) 775-784 Nov. 2010
  • Assessment of the biological similarity of three capsaicin analogs (Capsinoids) found in non-pungent chili pepper (CH-19 Sweet) fruits.
    Sasahara I, Furuhata Y, Iwasaki Y, Inoue N, Sato H, Watanabe T, Takahashi M
    Bioscience, biotechnology, and biochemistry 74(2) 274-278 2010
  • Activation of TRPV1 and TRPA1 by black pepper components.
    Okumura Y, Narukawa M, Iwasaki Y, Ishikawa A, Matsuda H, Yoshikawa M, Watanabe T
    Bioscience, biotechnology, and biochemistry 74(5) 1068-1072 2010
  • Galangal pungent component, 1'-acetoxychavicol acetate, activates TRPA1.
    Narukawa M, Koizumi K, Iwasaki Y, Kubota K, Watanabe T
    Bioscience, biotechnology, and biochemistry 74(8) 1694-1696 2010
  • Nesfatin-1 evokes Ca2+ signaling in isolated vagal afferent neurons via Ca2+ influx through N-type channels.
    Iwasaki Y, Nakabayashi H, Kakei M, Shimizu H, Mori M, Yada T
    Biochemical and biophysical research communications 390(3) 958-962 Dec. 2009
  • Miogadial and miogatrial with alpha,beta-unsaturated 1,4-dialdehyde moieties--novel and potent TRPA1 agonists.
    Iwasaki Y, Tanabe M, Kayama Y, Abe M, Kashio M, Koizumi K, Okumura Y, Morimitsu Y, Tominaga M, Ozawa Y, Watanabe T
    Life sciences 85(1-2) 60-69 Jul. 2009
  • Diallyl sulfides in garlic activate both TRPA1 and TRPV1.
    Koizumi K, Iwasaki Y, Narukawa M, Iitsuka Y, Fukao T, Seki T, Ariga T, Watanabe T
    Biochemical and biophysical research communications 382(3) 545-548 May 2009
  • TRPA1 and TRPV1 activation is a novel adjuvant effect mechanism in contact hypersensitivity.
    Shiba T, Maruyama T, Kurohane K, Iwasaki Y, Watanabe T, Imai Y
    Journal of neuroimmunology 207(1-2) 66-74 Feb. 2009
  • [Roles and functional interplay of the gut, brain stem, hypothalamus and limbic system in regulation of feeding].
    Suyama S, Takano E, Iwasaki Y, Nakata M, Yada T
    Nihon rinsho. Japanese journal of clinical medicine 67(2) 277-286 Feb. 2009
  • TRPA1 agonists--allyl isothiocyanate and cinnamaldehyde--induce adrenaline secretion.
    Iwasaki Y, Tanabe M, Kobata K, Watanabe T
    Bioscience, biotechnology, and biochemistry 72(10) 2608-2614 Oct. 2008
  • Monoacylglycerols activate capsaicin receptor, TRPV1.
    Iwasaki Y, Saito O, Tanabe M, Inayoshi K, Kobata K, Uno S, Morita A, Watanabe T
    Lipids 43(6) 471-483 Jun. 2008
  • Isolation of coniferyl esters from Capsicum baccatum L., and their enzymatic preparation and agonist activity for TRPV1.
    Kobata K, Tate H, Iwasaki Y, Tanaka Y, Ohtsu K, Yazawa S, Watanabe T
    Phytochemistry 69(5) 1179-1184 Mar. 2008
  • Newly synthesized oleylgingerol and oleylshogaol activate TRPV1 ion channels.
    Morita A, Iwasaki Y, Kobata K, Yokogoshi H, Watanabe T
    Bioscience, biotechnology, and biochemistry 71(9) 2304-2307 Sep. 2007
  • Lipophilicity of capsaicinoids and capsinoids influences the multiple activation process of rat TRPV1.
    Morita A, Iwasaki Y, Kobata K, Iida T, Higashi T, Oda K, Suzuki A, Narukawa M, Sasakuma S, Yokogoshi H, Yazawa S, Tominaga M, Watanabe T
    Life sciences 79(24) 2303-2310 Nov. 2006
  • Capsaicinol: synthesis by allylic oxidation and its effect on TRPV1-expressing cells and adrenaline secretion in rats.
    Kobata K, Iwasawa T, Iwasaki Y, Morita A, Suzuki Y, Kikuzaki H, Nakatani N, Watanabe T
    Bioscience, biotechnology, and biochemistry 70(8) 1904-1912 Aug. 2006
  • A nonpungent component of steamed ginger--[10]-shogaol--increases adrenaline secretion via the activation of TRPV1.
    Iwasaki Y, Morita A, Iwasawa T, Kobata K, Sekiwa Y, Morimitsu Y, Kubota K, Watanabe T
    Nutritional neuroscience 9(3-4) 169-178 Jun. 2006
  • Pungent qualities of sanshool-related compounds evaluated by a sensory test and activation of rat TRPV1.
    Sugai E, Morimitsu Y, Iwasaki Y, Morita A, Watanabe T, Kubota K
    Bioscience, biotechnology, and biochemistry 69(10) 1951-1957 Oct. 2005

Outside Fund Adoption

  • Cellular and molecular mechanism of hormone sensing on vagal afferents and its linking to the feeding
    Ministry of Education, Culture, Sports, Science and Technology:Grants-in-Aid for Scientific Research(若手研究(B))
    Project Year :2010 - 2011 Investigator(s) : Yusaku IWASAKI
Display all
Outside Fund Adoptionclose
  • Cellular and molecular mechanism of hormone sensing on vagal afferents and its linking to the feeding
    Ministry of Education, Culture, Sports, Science and Technology:Grants-in-Aid for Scientific Research(若手研究(B))
    Project Year :2010 - 2011 Investigator(s) : Yusaku IWASAKI


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