Researchers Database

yabe hiroki

    ComprehensiveMedicine1 Assistant Professor
Contact: yabehirokijichi.ac.jp
Last Updated :2021/10/17

Researcher Information

URL

J-Global ID

Research Interests

  • ankylosing spondylitis   psoriatic arthritis   clinical immunology   SAPHO syndrome   conective tissue disease   spondyloarthritis   Rheumatoid Arthritis   

Research Areas

  • Life sciences / Allergies and connective tissue disease
  • Life sciences / Allergies and connective tissue disease / Spondyloarthritis

Academic & Professional Experience

  • 2018/09 - Today  Jichi Medical UniversitySchool of Medicine講師
  • 2012/04 - 2018/08  Jichi Medical UniversitySchool of Medicine助教
  • 2010/04 - 2012/03  Jichi Medical Universityアレルギー・リウマチ科臨床助教
  • 2008/04 - 2010/03  川崎市立井田病院整形外科医長
  • 2006/04 - 2008/03  国立病院機構東京医療センター整形外科医員
  • 2002/04 - 2006/03  川崎市立川崎病院整形外科副医長
  • 1999/04 - 2002/03  東京歯科大学市川総合病院整形外科助手
  • 1998/10 - 1999/03  Keio University整形外科大学院生(腫瘍班)
  • 1996/04 - 1998/09  Keio University整形外科大学院生(同大学病理学教室留学)
  • 1995/07 - 1996/03  Keio University整形外科大学院生(脊椎班、膝関節班、腫瘍班)
  • 1994/07 - 1995/05  済生会神奈川県病院整形外科研修医
  • 1993/04 - 1994/06  Keio University整形外科研修医

Education

  • 1995/04 - 1999/03  慶應義塾大学大学院 医学研究科
  • 1987/04 - 1993/03  Keio University  School of Medicine

Association Memberships

  • JAPANESE SOCIETY OF ALLERGOLOGY   THE JAPAN SOCIETY FOR CLINICAL IMMUNOLOGY   日本脊椎関節炎学会   THE JAPANESE ORTHOPAEDIC ASSOCIATION   THE JANPANESE SOCIETY OF INTERNAL MEDICINE   JAPAN COLLEGE OF RHEUMATOLOGY   

Published Papers

  • Watanabe E, Tanaka A, Sugawara H, Nishina K, Yabe H, Gono T, Terai C
    The American journal of case reports 20 886 - 895 2019/06 [Refereed][Not invited]
  • Kaneko S, Watanabe E, Abe M, Watanabe S, Yabe H, Kojima S, Takagi K, Hirai K, Morishita Y, Terai C
    Journal of medical case reports 13 (1) 74  2019/03 [Refereed][Not invited]
  • 乳癌に対するドセタキセル治療後に発症した抗RNAポリメラーゼIII抗体陽性びまん皮膚硬化型全身性強皮症の一例
    矢部 寛樹, 桜井 正, 堤 智美, 小田 彩, 中村 考伸, 山田 朋子, 出光 俊郎, 黒岩 卓, 寺井 千尋
    自治医科大学紀要 (学)自治医科大学 41 61 - 66 1881-252X 2019/03 [Not refereed][Not invited]
     
    症例は41歳女性。当院初診3年2ヵ月前に乳癌に対しドセタキセル治療を、2年7ヵ月前に乳房温存術および放射線照射を受けた。2年前より右上肢リンパ浮腫を生じ、浮腫は左上肢、頸部に拡大。1年10ヵ月前から両上肢、両手部の皮膚硬化が進行、関節拘縮へ発展し、6ヵ月前からRaynaud現象、開口障害が出現し、当科を受診した。びまん皮膚硬化型全身性強皮症と診断し、入院の上、プレドニゾロン内服(20mg/日)を開始、進行する皮膚症状の改善目的にステロイドパルスを追加し、関節拘縮改善を認めた。本例はドセタキセル治療後の発症であり、上腕、前腕に浮腫、皮膚硬化が強く、一般の強皮症の末梢から体幹に拡がる皮膚硬化パターンと異なるため、ドセタキセル誘発皮膚硬化と考えた。一方、抗RNAポリメラーゼIII抗体陽性であり、皮膚硬化進行後にRaynaud現象を認めた経過から一般的な全身性強皮症の特徴を併せもつようになったと推測した。(著者抄録)
  • Kudo F, Watanabe Y, Iwai Y, Miwa C, Nagai Y, Ota H, Yabe H, Demitsu T, Hagiwara K, Koyama N, Koyama S
    Internal medicine (Tokyo, Japan) 57 (15) 2217 - 2221 0918-2918 2018/08 [Refereed][Not invited]
  • 永島 和貴, 中村 哲史, 梅本 尚可, 矢部 寛樹, 寺井 千尋, 野首 光弘, 吉田 尚弘, 出光 俊郎, 川瀬 正昭
    皮膚科の臨床 金原出版(株) 60 (7) 1095 - 1099 0018-1404 2018/06 [Not refereed][Not invited]
     
    <文献概要>44歳,女性。気管支喘息の既往あり。18日前より自覚した右頬部のしびれと,その後出現した同部の腫脹,鼻閉を主訴に受診した。初診時は血管性浮腫,蜂窩織炎を疑った。初診5日後,右頬部はさらに腫脹し紫斑を伴い,末梢血好酸球が増加した。MPO-ANCA,PR3-ANCAは陰性であった。病理組織所見で真皮から皮下の血管周囲の著明な好酸球浸潤と血管壁の破壊があり,好酸球性血管炎の像を呈した。多発性単神経炎,腹痛も認め,好酸球性多発血管炎性肉芽腫症と診断した。ステロイドパルス療法中にヘパリン起因性血小板減少症が誘因と推測される脳出血を併発した。本疾患の皮膚病変は下腿に好発するが,顔面に限局した極めてまれな症例と考えた。
  • Yabe H
    Internal medicine (Tokyo, Japan) 0918-2918 2018/05 [Refereed][Not invited]
  • 重篤な経過をたどった若年性ANCA関連血管炎の一例
    渡邉 萌理, 杉谷 直大, 阿部 麻衣, 渡邊 晋二, 矢部 寛樹, 寺井 千尋
    関東リウマチ 関東リウマチ研究会 (51) 78 - 82 0911-4807 2018/02 [Not refereed][Not invited]
  • Shinji Watanabe, Takahisa Gono, Kumiko Nishina, Naohiro Sugitani, Eri Watanabe, Hiroki Yabe, Chihiro Terai
    BMC IMMUNOLOGY 18 (1) 53  1471-2172 2017/12 [Refereed][Not invited]
     
    Background: Some patients with antineutrophil cytoplasmic antibody (ANCA)-associated vasculitis (AAV) also have positivity of rheumatoid factor (RF). However, the clinical significance of this occurrence remains unknown in AAV patients. The aim of this study was to clarify an association between the presence of RF and clinical features in patients with AAV. Results: Forty-seven patients diagnosed with AAV who were not complicated with RA were enrolled in this study. We compared clinical manifestations of AAV between an RF-positive subset (n = 29) and an RF-negative subset (n= 18). The Birmingham Vasculitis Activity Score (BVAS) was higher (P = 0.026) in the RF-positive subset than in the RF-negative subset. The levels of CRP and ESR were higher in the RF-positive patients (P = 0.020 and P = 0.007, respectively) compared to the RF-negative subset. IgM-RF titers were significantly correlated with the BVAS (r = 0.50, P = 0.0004). In addition, the IgM-RF titers had significant correlations with the levels of CRP (r= 0.41, P = 0.004), ESR (r = 0.39, P = 0.016), IgM (r = 0.36, P = 0.016) and IgG (r = 0.37, P = 0.015). The frequency of commencement of dialysis therapy, usage of mechanical ventilation and mortality were higher in the RF-positive subset than in the RF-negative subset. Conclusions: In patients with AAV, RF titers were significantly correlated with disease activity and the levels of inflammatory markers. The presence of RF could be a poor prognostic factor in patients with AAV.
  • Hughes–Stovin syndrome with pulmonary aneurysms and renal dysfunction mimicking polyarteritis nodosa
    Watanabe E, Nishina K, Yabe H, Gono T, Terai C
    J Mod Rheumatol Case Rep (Published online); https://doi.org/10.1080/24725625.2017.1379168 2017 [Refereed][Not invited]
  • Shoichi Hasegawa, Hiroki Yabe, Naoya Kaneko, Eri Watanabe, Takahisa Gono, Chihiro Terai
    INTERNAL MEDICINE 56 (20) 2779 - 2783 0918-2918 2017 [Refereed][Not invited]
     
    We herein report a rare case of a 66-year-old woman who had synovitis-acne-pustulosis-hyperostosis-osteitis (SAPHO) syndrome with marked sternal osteitis and bilateral pleural effusions. SAPHO syndrome was diagnosed based on the characteristic features of a hyperostotic sternum and thoracic spine. The inflammatory changes of sternal osteitis and involvement of the adjacent soft tissue were assumed to be the cause of the pleural effusions. The effusions decreased during the natural course of the disease and resolved after methotrexate therapy. The pain dramatically decreased with oral tramadol. Physicians should consider the possibility of SAPHO syndrome in patients with anterior chest pain and pleural effusions.
  • 大動脈炎症候群に合併したクローン病の1例
    鷺原 規喜, 井上 依里, 矢部 寛樹, 賀嶋 ひとみ, 小糸 雄大, 石井 剛弘, 坪井 瑠美子, 田村 洋行, 上原 健志, 大竹 はるか, 池田 正俊, 新藤 雄司, 川村 晴水, 西川 剛司, 大滝 雄造, 浦吉 俊輔, 山中 健一, 牛丸 信也, 浅野 岳晴, 岩城 孝明, 松本 吏弘, 浅部 伸一, 宮谷 博幸, 田中 裕一, 野首 光弘, 眞嶋 浩聡
    自治医科大学紀要 (学)自治医科大学 38 59 - 63 1881-252X 2016/03 [Not refereed][Not invited]
     
    31歳女性。大動脈炎症候群の治療中に、血便を認め当センターに入院した。下部消化管内視鏡検査にて、終末回腸に縦走潰瘍を認め、小腸型クローン病と診断した。寛解導入療法として、栄養療法とメサラジン製剤の内服に加え、生物学的製剤アダリムマブを投与した。寛解を得た後、プレドニゾロン・メトトレキセートの減量を行ったが、両疾患とも再燃・悪化なく経過している。両疾患の合併は稀であり、本邦からの報告例が19例、国外からの報告例を加えると55例に過ぎない。発症の順序に規則性は認めない。今回貴重な症例を経験したので、文献的考察を加え、報告する。(著者抄録)
  • MTX、TAC投与中に他院でクラリスロマイシン投与をうけその後PCPを発症したRAの一例
    小田 彩, 吉田 克之, 渡邊 萌理, 矢部 寛樹, 寺井 千尋
    関東リウマチ 関東リウマチ研究会 (48) 212 - 219 0911-4807 2015/05 [Not refereed][Not invited]
     
    65歳女。13年前に関節リウマチ(RA)を発症し、メトトレキサート(MTX)、プレドニゾロン(PSL)、タクロリムス(TAC)投与により寛解を維持していた。PSLは入院3ヵ月前には中止していた。入院3週間前にTAC血中濃度が著明に上昇したため、0.5mg/日に減量した。その後、全身倦怠感、発熱、労作時息切れが出現し、歩行困難となり受診した。CTでびまん性にモザイク状のスリガラス影を認めたことから、ニューモシスチス肺炎(PCP)が疑われ緊急入院となった。服薬歴を聴取したところ、他院より感冒様症状に対してクラリスロマイシンが投与されていたことが判明した。病歴と典型的なCT所見より、PCPの診断的治療を開始した。症状は速やかに改善したが、治療開始14日目に皮疹が出現し、ST合剤からペンタミジンに変更した。
  • 強皮症に合併した治療抵抗性間質性肺炎に対する自己末梢血幹細胞移植の経験
    小熊 慶子, 小田 彩, 堤 智美, 矢部 寛樹, 櫻井 正, 寺井 千尋, 神田 善伸
    関東リウマチ 関東リウマチ研究会 (47) 316 - 323 0911-4807 2014/04 [Not refereed][Not invited]
     
    症例は32歳女性で、レイノー現象、手指の皮膚硬化を認め、手指のこわばり、皮膚硬化が進行したため受診し、瀰漫性皮膚硬化型強皮症(deSSc)と診断された。抗Scl-70抗体陽性、食道拡張、間質性肺炎を認めた。プレドニゾロン(PSL)、IVCYを投与されタクロリムス(TAC)を併用し、TAC増量、PSL減量とした。さらにTACをシクロホスファミド(CY)内服に変更した。胸部CTで診断時に比べ明らかに間質性肺炎の進行を認めた。TAC、CYにも治療抵抗性で自己末梢血幹細胞移植を選択した。予防的抗菌薬としてフルコナゾール、アシクロビル、レボフロキサシンを投与していたが、幹細胞輸注前に発熱したため、レボフロキサシンをセフェピムに変更した。合併症なく11日後に血球は回復した。
  • Parsonage-Turner Syndrome Initially Suspected of Being Orthopedic Diseases in a Primary Care Setting
    Hiroki Yabe, Machiko Kimura, Akira Ishii, Tamami Watanabe, Yoshio Sakiyama, Mieko Otsuka, Hitoshi Sugawara
    Journal of Medical Cases 5 (4) 197 - 201 2014/04 [Refereed][Not invited]
  • Value of Prostate-Specific Antigen Elevated in Transudative Pleural Effusion for Diagnosis of Prostate Cancer-Induced Paramalignant Pleural Effusion
    Naoko Fujiwara, Hitoshi Sugawara, Hiroki Yabe, Akira Ishii, Hiroshi Matsubayashi, Tamami Watanabe, Masafumi Kakei, Yutaka Kobayashi, Yoh Dobashi
    Journal of Medical Cases 4 (7) 507 - 510 2013/07 [Refereed][Not invited]
  • 器質化肺炎を合併した抗CCP抗体陽性乾癬性関節炎の一例
    中山由梨, 矢部寛樹, 野中彩, 堤智美, 黒岩卓, 寺井千尋
    関東リウマチ 46 279 - 286 2013 [Not refereed][Not invited]
  • Subtrochanteric pseudoarthrosis occurred with early breakage of IMHS (Intramedullary Hip Screw): A case report
    YABE Hiroki, OKA Sayaka, TAKAHASHI Masaaki, MATSUZAKI Kenichiro, YOKOI Akio, SUEKI Hitoshi, YAMAMOTO Munehiro, HAYASHI Toshikichi, USUI Hiroshi
    Kanto Journal of Orthopedics and Traumatology 43 (6) 443 - 448 2012/12 [Refereed][Not invited]
  • Kensuke Ochi, Yukio Horiuchi, Miyoka Seki, Kazuo Nishi, Hiroyuki Nozaki, Hiroki Yabe
    RHEUMATOLOGY INTERNATIONAL 32 (8) 2557 - 2559 0172-8172 2012/08 [Refereed][Not invited]
     
    Cancer polyarthritis is a very rare condition. Here, we present a case of cancer polyarthritis, who also had mononeuritis simplex as a manifestation of paraneoplastic neuralgic syndrome. A 71-year-old man, who initially presented symmetrical polyarthritis and unilateral posterior interosseous nerve palsy, was subsequently diagnosed to have gastric cancer. Total gastrectomy was performed, and his polyarthritis and the palsy simultaneously disappeared within 2 weeks after the resection. His gastric cancer was found to be metastasized to his liver 16 months after the total gastrectomy; however, the polyarthritis and the palsy did not recurrent throughout his course. The polyarthritis in this case was diagnosed as a cancer polyarthritis from its features. On the other hand, the isolated posterior interosseous nerve palsy in this case met the diagnostic criteria for paraneoplastic neurological syndrome. This case was also unique in that the manifestations of paraneoplastic syndromes did not recur even after the metastasis of the primary cancer, suggesting that some specific clones in the cancer were responsive to the manifestations of paraneoplastic syndromes. Our case suggested that relapse of the manifestations of paraneoplastic syndromes may not always herald the recurrence of primary or metastatic tumour, and other tumour markers and signs should be periodically followed to search for the recurrence of the tumours.
  • Kensuke Ochi, Yukio Horiuchi, Takashi Matsumura, Mitsukazu Nakamura, Terue Takei, Hiroki Yabe
    MODERN RHEUMATOLOGY 2 22 (2) 290 - 294 1439-7595 2012/04 [Refereed][Not invited]
     
    We report a case of distal radius fracture after a Sauv,-Kapandji procedure combined with synovectomy and tendon transfer in a rheumatoid arthritis patient. This case shared several unusual features that were also seen in a previously reported case. Based on these features, we discuss favorable surgical treatment for the rheumatoid wrist with extensor tendon rupture, and also the optimal treatment for distal radius fracture after such procedures.
  • 間質性肺炎との鑑別が困難な Moraxella (Branhamella) catarrhalis肺炎を合併した多発性筋炎の一剖検例
    野中 彩, 堤 智美, 矢部 寛樹, 櫻井 正, 黒岩 卓, 寺井 千尋
    関東リウマチ 45 192 - 200 2012/03 [Not refereed][Not invited]
  • 矢部寛樹, 小松研郎, 森岡秀夫, 小柳貴裕
    神奈川整形災害外科研究会雑誌 24 (5) 225-228  1348-043X 2012/03 [Refereed][Not invited]
  • Hiroki Yabe, Akira Ishii, Naoko Niikawa, Hiroshi Matsubayashi, Masafumi Kakei, Masanobu Kawakami, Hitoshi Sugawara
    INTERNAL MEDICINE 51 (11) 1429 - 1432 0918-2918 2012 [Refereed][Not invited]
     
    Spontaneous spinal epidural hematoma (SSEH) is an uncommon but clinically important disease, and delayed diagnosis of this condition can have severe consequences. General physicians should consider the possibility of SSEH when they encounter a patient with a sudden onset of unexplained cervical or back pain or subsequent radicular symptoms during anticoagulant therapy. Immediate magnetic resonance imaging is essential for early diagnosis. In this article, we present a rare case of an 80-year-old man who developed cervical SSEH during warfarin therapy.
  • KOMATSU Kenro, YABE Hiroki, KOYANAGI Takahiro, MATSUTANI Tetsuyuki, NAKANO Yasushi, NISHIO Kazuo
    日本外科系連合学会誌 36 (2) 238 - 244 1882-9112 2011/04 [Refereed][Not invited]
  • Hiroki Yabe, Tomohide Tsukahara, Satoshi Kawaguchi, Takuro Wada, Toshihiko Torigoe, Noriyuki Sato, Chihiro Terai, Masaya Aoki, Shigemichi Hirose, Hideo Morioka, Hiroo Yabe
    JOURNAL OF SURGICAL ONCOLOGY 103 (5) 380 - 385 0022-4790 2011/04 [Refereed][Not invited]
     
    Background: Ewing's sarcoma family of tumors (ESFT) is one of the most malignant groups of tumors in young people. Human leukocyte antigen (HLA) class I displays endogenously processed peptides to CD8+ T lymphocytes and has a key role for host immune surveillance. In ESFT, the investigation concerning both HLA class I expression and T-cell infiltration has yet to be reported. Methods: Biopsy specimens from 28 ESFT patients were evaluated by immunohistochemistry with the anti-HLA class I monoclonal antibody (mAb) EMR8-5 and anti-CD8 mAb, respectively. Results: Expression of HLA class I was negative in 10 tumors and down-regulated in 22 tumors. The status of CD8+ T cell infiltration was closely associated with the expression levels of HLA class I. ESFT patients with down-regulated or negative expression of HLA class I showed significantly poorer survival than the rest of the patients. Conclusions: Our results suggested that CD8+T cell-mediated immune response restricted by HLA class I might play an important role in immune surveillance of ESFT, and we revealed for the first time that the status of HLA class I expression affects the survival of the patients with ESFT. J. Surg. Oncol. 2011; 103: 380-385. (C) 2010 Wiley-Liss, Inc.
  • 小松研郎, 矢部寛樹, 小柳貴裕
    神奈川整形災害外科研究会雑誌 23 (4) 103-106  1348-043X 2011/03 [Refereed][Not invited]
  • Chiba E, Oda A, Tsutsumi T, Yabe H, Kamiya Y, Sakurai T, Moriguchi M, Momomura S, Terai C
    Nihon Naika Gakkai zasshi. The Journal of the Japanese Society of Internal Medicine 日本内科学会 100 (2) 483 - 486 0021-5384 2011/02 [Refereed][Invited]
  • Hiroki Yabe, Hironori Ueno, Kensuke Ochi, Hideo Morioka, Hiroo Yabe, Chihiro Terai
    Case Reports in Oncology 4 (1) 125 - 131 1662-6575 2011/01 [Refereed][Not invited]
     
    In two patients with primary bone lymphoma (PBL) treated in our clinic, serum levels of soluble interleukin-2 receptor (sIL-2R) reflected the clinical course. In both cases, sIL-2R levels were high before treatment and normalized with the therapeutic effects of chemotherapy, coinciding with the changes in lactate dehydrogenase levels and radiographic findings. Adding to the recently reported results of the diagnostic ability of sIL-2R in PBL, our case study highlights the clinical significance of serum sIL-2R levels as a tumor marker in PBL cases. © 2011 S. Karger AG, Basel.
  • 小松研郎, 矢部寛樹, 小柳貴裕, 野本聡
    日本人工関節学会誌 40 286-287  1345-7608 2010/12 [Refereed][Not invited]
  • Kensuke Ochi, Yukio Horiuchi, Kenichi Tazaki, Kazuo Nishi, Hidekazu Kawashima, Hiroki Yabe
    MODERN RHEUMATOLOGY 20 (5) 514 - 517 1439-7595 2010/10 [Refereed][Not invited]
     
    A 74-year-old woman diagnosed with Churg-Strauss syndrome (CSS) complained of difficulty in flexing her left thumb and index finger. Electromyography demonstrated isolated anterior interosseous nerve (AIN) palsy, with no other peripheral neuropathy. We diagnosed this case as spontaneous AIN palsy complicated with CSS, the first case of this kind. Surgical treatment should be considered if no sign of recovery is seen within six months of onset.
  • Hiroki Yabe, Hisaji Ohshima, Yoji Takano, Takahiro Koyanagi, Hiroshi Usui, Kenya Nojiri, Kensuke Ochi, Michiya Kihara, Yukio Horiuchi
    RHEUMATOLOGY INTERNATIONAL 30 (10) 1277 - 1283 0172-8172 2010/08 [Refereed][Not invited]
     
    Since the term synovitis-acne-pustulosis-hyperostosis-osteitis (SAPHO) syndrome was proposed by Chamot et al. (Rev Rhum Mal Osteoartic 54:187-196, 1987), clinical reviews concerning this syndrome have been mainly reported from Europe. We carried out a retrospective analysis of 11 Japanese patients with SAPHO syndrome, and reviewed the clinical features of our series in comparison with those in a European large case study. In this study the major features of SAPHO syndrome were chronic osteitis of the anterior chest wall and pustulotic arthro-ostitis with middle age onset, and mucosal lesions seemed to be a minor complication of SAPHO syndrome. The non-erosive peripheral large joints arthritis and the particular HLA types (HLA-B51, B52, or A26), which had been reported to be increased in Behcet's disease, were frequently seen in SAPHO syndrome with mucosal lesions. This study also suggests that SAPHO syndrome with mucosal lesions may be part of a broader disease spectrum including Behcet's disease.
  • 森岡秀夫, 矢部寛樹, 鈴木禎寿, 中山ロバート, 保坂聖一, 矢部啓夫
    PEPARS (32) 44-52  1349-645X 2009/08 [Not refereed][Not invited]
  • Kazutaka Kikuta, Naobumi Tochigi, Tadakazu Shimoda, Hiroki Yabe, Hideo Morioka, Yoshiaki Toyama, Ako Hosono, Yasuo Beppu, Akira Kawai, Setsuo Hirohashi, Tadashi Kondo
    CLINICAL CANCER RESEARCH 15 (8) 2885 - 2894 1078-0432 2009/04 [Refereed][Not invited]
     
    Purpose: We aimed to identify novel prognostic biomarkers for Ewing's sarcoma by investigating the global protein expression profile of Ewing's sarcoma patients. Experimental Design: We examined the proteomic profile of eight biopsy samples from Ewing's sarcoma patients using two-dimensional difference gel electrophoresis. Three patients were alive and continuously disease-free over 3 years after the initial diagnosis (good prognosis group) and five had died of the disease within 2 years of the initial diagnosis (poor prognosis group). Results: The protein expression profiles produced using two-dimensional difference gel electrophoresis consisted of 2,364 protein spots, among which we identified 66 protein spots whose intensity showed >2-fold difference between the two patient groups. Mass spectrometric protein identification showed that the 66 spots corresponded to 53 distinct gene products. Pathway analysis revealed that 31 of 53 proteins, including nucleophosmin, were significantly related to bone tissue neoplasms (P < 0.000001). The prognostic performance of nucleophosmin was evaluated immunohistochemically on an additional 34 Ewing's sarcoma cases. Univariate and multivariate analyses revealed that nucleophosmin expression significantly correlated with overall survival (P < 0.01). Conclusions: These results establish nucleophosmin as a candidate of independent prognostic marker for Ewing's sarcoma patients. Measuring nucleophosmin in biopsy samples before treatment may contribute to the effective management of Ewing's sarcoma.
  • 矢部 寛樹, 松崎 健一郎, 山本 宗宏
    日本脊椎関節炎学会誌 日本脊椎関節炎学会 1 (2) 45 - 50 2009 [Refereed][Not invited]
  • Hiroki Yabe, Yoji Takano, Eiki Nomura, Masanori Nakayama, Michiya Kihara, Shun-ichi Miyakawa, Yukio Horiuchi
    CLINICAL RHEUMATOLOGY 27 (1) 133 - 135 0770-3198 2008/01 [Refereed][Not invited]
     
    We describe two patients with SAPHO (synovitis-acne-pustulosis-hyperostosis-ostitis) syndrome who presented some of the classic features of Behcet's disease. The first case is a man diagnosed as SAPHO at 74 years old. His major complaint is pain and swelling of the bilateral sterno-clavicular region for more than 14 years. Another conspicuous complication was bilateral glaucoma and episodes of iritis were recognized during the follow-up period. The second case is a 65-year-old woman, who first consulted us with right knee pain. As she had a past history of palmoplantar pustulosis and anterior chest pain, her sterile knee arthritis was diagnosed as SAPHO. She also had been suffering from recurrent oral aphthous ulceration since 6 months before visiting our hospital. Considering the clinical courses of our two cases and a review of five previously reported cases, these conditions may imply that classic features of Behcet's disease are minor complications of SAPHO syndrome. Human leukocyte antigen typing and frequent association of sacroiliitis in our cases and in the review of the literature for SAPHO syndrome with some of the classic features of Behcet's disease may indicate this condition to be a closely related disease with seronegative spondylo-arthritis.
  • Hiroki Yabe, Tomohide Tsukahara, Satoshi Kawaguchi, Takuro Wada, Noriyuki Sato, Hideo Morioka, Hiroo Yabe
    ONCOLOGY REPORTS 19 (1) 129 - 134 1021-335X 2008/01 [Refereed][Not invited]
     
    Ewing's sarcoma family of tumors (ESFT) is comprised of highly malignant bone and soft tissue tumors in children and young adults. Despite intensive treatments for patients with ESFT, disease which presents with metastatic spread or relapses after primary treatment remains incurable in the majority of cases, indicating the importance of efforts to develop new treatment modalities, including immunotherapy. The present study was designed to examine the expression profile of papillomavirus binding factor (PBF), which we previously defined as an osteosarcoma-associated antigen, and its prognostic significance for patients with ESFT. Biopsy specimens from 20 ESFT were stained with an anti-PBF antibody. Survival was estimated using Kaplan-Meier plots and the prognostic significance of several variables, including the expression status of PBF, on disease-free and overall survival was determined by univariate analysis using the log-rank test. Of 20 specimens, 18 (90%) reacted positively to the anti-PBF antibody. Fifteen specimens (75%) were graded as PBF overexpression. Of the I I variables analyzed, stage III disease, inadequate surgical margins and PBF overexpression were significantly associated with decreased disease-free and overall survival. None of the other variables, including age, gender, origin of tumor, tumor site or levels of LDH, ALP, CRP and ESR, showed any significant association. These findings indicate that the overexpression of PBF is a factor indicative of poor prognosis in ESFT. PBF may also serve as a putative target antigen in immunotherapy for patients with ESFT that have a poor prognosis and PBF overexpression.
  • 林俊吉, 長田夏哉, 堀内行雄, 阿部耕治, 細金直文, 矢部寛樹, 野村栄貴, 木原未知也
    神奈川整形災害外科研究会雑誌 19 (4) 117-119  1348-043X 2007/04 [Refereed][Not invited]
  • 佐藤章子, 矢部寛樹, 堀内行雄, 木原未知也, 野村栄貴, 仁平高太郎, 長田夏哉, 細金直文
    神奈川整形災害外科研究会雑誌 18 (3) 59-62  1348-043X 2005/11 [Refereed][Not invited]
  • H Yabe, M Fukuma, F Urano, K Yoshida, S Kato, Y Toyama, J Hata, A Umezawa
    BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS 293 (1) 61 - 71 0006-291X 2002/04 [Refereed][Not invited]
     
    Ewing sarcoma is a malignant bone and soft tissue tumor of children and young adults, which is known to be highly aggressive and invasive. It expresses specific chimeric genes (EWS-FLI-1, EWS-ERG, EWS-ETV1. and EWS-E1AF), the 3' portions of which are all members of the ETS family. ETS-related proteins, such as FLI-1. ERG, and E1AF, transactivate the promoters of matrix metalloproteinase (MMP) genes. which play important roles in the processes of invasion and metastasis. Therefore. we hypothesize that the Ewing sarcoma-specific chimeric genes also transactivate the MMP genes, contributing to the tumor's invasiveness and propensity for metastasis. To verify this hypothesis, we investigated the expression of MMPs in eight Ewing sarcoma cell lines. Surprisingly, MMP-1 and MMP-3 were not expressed at all in any of the cell lines. MMP-9 was expressed in four out of the eight cell lines, and MMP-2 and MT1-MMP in all of the cell lines. Ewing sarcoma-specific chimeric genes have been shown to transactivate the promoter of the MMP-1 gene by the reporter assay, and bind to the putative recognition sites in the MMP regulatory elements by the gel shift assay. However, an in vivo formaldehyde cross-linking study revealed that the chimeric protein did not bind to the predicted ETS recognition sites in the regulatory elements of the MMPs. These results indicate that the absence of the MMP expression in the tumor cells is at least in part due to the loss of accessibility of the ETS recognition sites in the regulatory elements of the MMP genes. Therefore, we should be careful before theorizing simply that a putative binding site is essential for the transcription of critical genes, since the binding of this fusion protein was found to be modulated in tumor cells in this study. (C) 2002 Elsevier Science (USA). All rights reserved.
  • 越智健介, 矢部啓夫, 森岡秀夫, 森井健司, 加藤正二郎, 矢部寛樹, 戸山芳昭
    整形外科 52 (6) 635-638  0030-5901 2001/06 [Not refereed][Not invited]
  • 創健B型により治癒できなかった先天性下腿偽関節症の創健社製平型磁気治療器(創健F型)による治療
    高橋正憲, 小柳貴裕, 川久保誠, 穴沢卯圭, 矢部寛樹, 高尾努, 宮本敏治, 福田みどり, 清田幸子, 境友子
    日本磁気医学会誌 26 3 - 23 1999 [Refereed][Not invited]
  • F Urano, A Umezawa, H Yabe, W Hong, K Yoshida, K Fujinaga, J Hata
    JAPANESE JOURNAL OF CANCER RESEARCH 89 (7) 703 - 711 0910-5050 1998/07 [Refereed][Not invited]
     
    Ewing's sarcoma, one of the most malignant tumors of children and young adults, expresses specific chimeric genes, e.g. EWS-FL1-1, EWS-ERG, EWS-ETV1 and EWS-FEV. In this paper, we extensively characterized a new fusion gene, EWS-E1AF by means of whole cDNA sequencing, RNA blot analysis, DNA blot analysis and chromosomal analysis, and showed it to be available for the diagnosis of Ewing's sarcoma and to participate in the oncogenesis of Ewing's sarcoma, Furthermore, we conducted a genetic analysis of Ewing family tumors in conjuction with immunohistochemical analysis and ultrastructural analysis. Our results demonstrate some limitations of both genetic analysis and histopathological analysis, and establish the relationship between neurogenic phenotypes and chimera genes.
  • YABE HIROKI, YABE HIROO, MORIOKA HIDEO, NAGUMO TAKESHI, ISAKI HISAYUKI, HANAOKA HIDEYA
    整形外科 48 (10) 1307-1311  0030-5901 1997/09 [Not refereed][Not invited]
  • YABE HIROKI, SUZUKI NOBUMASA, TOYAMA YOSHIAKI, FUJIMURA SHOICHI, TEZUKA MASAKI
    関東整形災害外科学会雑誌 27 (5) 413-417  0389-7087 1996/10 [Refereed][Not invited]
  • NOMOTO So, SASAKI Takashi, NAGAYAMA Nobuyuki, YAMANAKA Kazuyoshi, NONOMIYA Hiroaki, INOUE Kunio, MASUDA Kazuyuki, ABE Tomoyuki, YABE Hiroki
    関節鏡 20 (2) 161 - 165 0910-223X 1995/10 [Not refereed][Not invited]

Books etc

  • リウマチ病学テキスト 改訂第2版
    矢部 寛樹 (ContributorSAPHO症候群)
    診断と治療社 2016
  • 総合診療力を磨く「40」の症候・症例カンファレンス
    矢部 寛樹 (Contributor皮疹(発熱を伴う))
    南江堂 2014 167-169
  • 整形外科専門医になるための診療スタンダード4 骨・軟部腫瘍および骨系統・代謝性疾患
    矢部 寛樹 (ContributorEwing肉腫/PNET,脊索腫,多発性骨髄腫,骨原発性悪性リンパ腫)
    羊土社 2009/04

Conference Activities & Talks

  • リウマチ治療におけるオレンシア(R)の位置づけ  [Not invited]
    矢部 寛樹
    リウマチ エリアWEBセミナー  2019/11
  • リウマチ性疾患と整形外科とのつながり 「アバタセプトによるRA治療の可能性」  [Not invited]
    矢部 寛樹
    大宮医師会学術講演会(第3回大宮整形外科医会学術講演会)  2019/10
  • SAPHO症候群の最新の知見  [Not invited]
    矢部 寛樹
    第30回さいたま市合同リウマチカンファレンス  2019/10

MISC

  • 当院におけるGLM使用RA患者の臨床的特徴
    堀 博志, 小橋川 剛, 八子 徹, 渡邉 萌理, 矢部 寛樹, 寺井 千尋, 小竹 茂  日本リウマチ学会総会・学術集会プログラム・抄録集  63回-  618  -618  2019/03  [Not refereed][Not invited]
  • ゾレドロン酸によってヒト末梢血から誘導されるγδT細胞ではinterferon stimulated gene 15kDa(ISG15)発現が増加している
    八子 徹, 川本 学, 南家 由紀, 山中 寿, 小橋川 剛, 矢部 寛樹, 渡邉 萌理, 小竹 茂  日本リウマチ学会総会・学術集会プログラム・抄録集  63回-  664  -664  2019/03  [Not refereed][Not invited]
  • 高安動脈炎における生物学的製剤治療例の検討
    矢部 寛樹, 渡邉 萌理, 寺井 千尋, 小橋川 剛, 八子 徹, 小竹 茂  日本リウマチ学会総会・学術集会プログラム・抄録集  63回-  719  -719  2019/03  [Not refereed][Not invited]
  • 自治医大さいたま医療センターにおけるベーチェット病患者の特徴
    小橋川 剛, 八子 徹, 渡邉 萌理, 矢部 寛樹, 小竹 茂  日本リウマチ学会総会・学術集会プログラム・抄録集  63回-  797  -797  2019/03  [Not refereed][Not invited]
  • ブドウ膜炎治療中に偶発的に発見された鎖骨下動脈を合併し口腔内潰瘍を伴わないベーチェット病例
    眞鍋 尭彦, 小橋川 剛, 渡邉 萌理, 矢部 寛樹, 八子 徹, 小竹 茂  日本リウマチ学会総会・学術集会プログラム・抄録集  63回-  799  -799  2019/03  [Not refereed][Not invited]
  • 多発性皮下脂肪織炎を伴ったTIF1-γ抗体陽性皮膚筋炎の1例
    塚原 理恵子, 川瀬 正昭, 山田 真嗣, 高澤 摩耶, 永島 和貴, 山田 朋子, 梅本 尚可, 出光 俊郎, 矢部 寛樹  日本皮膚科学会雑誌  128-  (3)  447  -447  2018/03  [Not refereed][Not invited]
  • SAPHO症候群における臨床的特徴およびHLAタイピングの検討
    矢部 寛樹, 寺井 千尋, 五野 貴久, 小柳 貴裕, 越智 健介  日本整形外科学会雑誌  92-  (2)  S101  -S101  2018/03  [Not refereed][Not invited]
  • 関節リウマチの関節外病変 関節リウマチにおける抗シトルリン化ペプチド抗体価と間質性肺炎の関連に関する検討
    阿部 麻衣, 杉谷 直大, 渡邉 晋二, 渡邊 萌理, 矢部 寛樹, 寺井 千尋  日本リウマチ学会総会・学術集会プログラム・抄録集  62回-  437  -437  2018/03  [Not refereed][Not invited]
  • 関節リウマチの関節外病変 MTX-LPD併発RAの臨床的検討
    矢部 寛樹, 寺井 千尋, 阿部 麻衣, 渡邉 萌理, 渡邉 晋二  日本リウマチ学会総会・学術集会プログラム・抄録集  62回-  437  -437  2018/03  [Not refereed][Not invited]
  • 多発性筋炎/皮膚筋炎における血清CD146の検討
    渡邉 萌理, 五野 貴久, 阿部 麻衣, 渡邊 晋二, 矢部 寛樹, 桑名 正隆, 加藤 和則, 寺井 千尋  日本リウマチ学会総会・学術集会プログラム・抄録集  62回-  666  -666  2018/03  [Not refereed][Not invited]
  • 微小メサンギウムループス腎炎によりネフローゼ症候群を呈した1例
    栗原 維吹, 阿部 麻衣, 渡邊 晋二, 渡邉 萌理, 矢部 寛樹, 寺井 千尋  日本内科学会関東地方会  639回-  51  -51  2018/02  [Not refereed][Not invited]
  • 播種性非結核性抗酸菌症の治療中に難治性呼吸器病変を併発した全身性エリテマトーデスの一例
    阿部 麻衣, 渡邊 晋二, 渡邉 萌理, 矢部 寛樹, 寺井 千尋  日本リウマチ学会関東支部学術集会プログラム・抄録集  28回-  58  -58  2017/12  [Not refereed][Not invited]
  • 全身性強皮症に分節性動脈中膜融解を合併し、腎クリーゼによる血圧上昇から腹腔内出血を来した一例
    金子 昌平, 渡邉 萌理, 阿部 麻衣, 渡邊 晋二, 矢部 寛樹, 小島 成浩, 高木 賢治, 平井 啓之, 森下 義幸, 寺井 千尋  日本リウマチ学会関東支部学術集会プログラム・抄録集  28回-  84  -84  2017/12  [Not refereed][Not invited]
  • 関節リウマチの関節外病変 生物学的製剤投与下での肺病変併発関節リウマチにおける新たな肺イベントに関する危険因子の同定
    杉谷 直大, 五野 貴久, 渡邊 晋二, 渡邉 萌理, 矢部 寛樹, 寺井 千尋  日本リウマチ学会総会・学術集会プログラム・抄録集  61回-  518  -518  2017/03  [Not refereed][Not invited]
  • 脊椎関節炎に対する生物学的製剤治療効果の検討
    矢部 寛樹, 杉谷 直大, 渡邊 晋二, 渡邉 萌理, 五野 貴久, 寺井 千尋  日本リウマチ学会総会・学術集会プログラム・抄録集  61回-  812  -812  2017/03  [Not refereed][Not invited]
  • 多発性筋炎/皮膚筋炎における筋炎特異自己抗体別にみた寛解率に関する検討
    渡邉 萌理, 五野 貴久, 杉谷 直大, 渡邊 晋二, 矢部 寛樹, 桑名 正隆, 寺井 千尋  日本リウマチ学会総会・学術集会プログラム・抄録集  61回-  824  -824  2017/03  [Not refereed][Not invited]
  • 多発腎梗塞と大量の腎動脈出血を来し結節性多発動脈炎(PAN)との鑑別を要した分節性動脈中膜融解(segmental arterial mediolysis:SAM)の1例
    石川 輝, 渡邉 萌理, 杉谷 直大, 渡邊 晋二, 矢部 寛樹, 五野 貴久, 寺井 千尋  日本内科学会関東地方会  630回-  76  -76  2017/02  [Not refereed][Not invited]
  • SAPHO症候群における臨床的特徴およびHLAタイピングの検討
    矢部 寛樹, 寺井 千尋, 五野 貴久, 渡邉 萌理, 渡邊 晋二, 阿部 麻衣, 越智 健介, 小柳 貴裕  日本脊椎関節炎学会誌  (Suppl.)  36  -36  2017/01  [Not refereed][Not invited]
  • 当院での脊椎関節炎に対する生物学的製剤治療効果の検討
    矢部 寛樹, 寺井 千尋, 五野 貴久, 渡邉 萌理, 渡邊 晋二, 阿部 麻衣  日本脊椎関節炎学会誌  (Suppl.)  43  -43  2017/01  [Not refereed][Not invited]
  • 扁桃摘出術および禁煙が有効であったSAPHO症候群の1例
    矢部 寛樹, 仁科 久美子, 渡邉 萌理, 五野 貴久, 寺井 千尋  日本リウマチ学会総会・学術集会プログラム・抄録集  60回-  544  -544  2016/03  [Not refereed][Not invited]
  • NMDA型GluR抗体が検出された髄膜脳炎発症の混合性結合組織病の一例
    眞山 英徳, 柴田 頌太, 小野 さやか, 崎山 快夫, 矢部 寛樹, 寺井 千尋, 高橋 利幸  臨床神経学  55-  (4)  279  -279  2015/04  [Not refereed][Not invited]
  • 岩井 悠希, 渡辺 恭孝, 川村 留美, 白石 守, 三輪 千尋, 矢部 寛樹, 小山 信之, 寺井 千尋, 讃井 將満, 山田 茂樹, 小山 信一郎  気管支学  37-  (1)  122  -122  2015/01  [Not refereed][Not invited]
  • 強直性脊椎炎に関節リウマチを併発した1例
    矢部 寛樹, 野中 彩, 堤 智美, 櫻井 正, 森口 正人, 寺井 千尋  日本リウマチ学会総会・学術集会・国際リウマチシンポジウムプログラム・抄録集  57回・22回-  535  -535  2013/03  [Not refereed][Not invited]
  • 下肢動脈瘤で発症した血管ベーチェットの2例
    北野 泰佑, 野中 彩, 堤 智美, 矢部 寛樹, 黒岩 卓, 百村 伸一, 寺井 千尋  日本内科学会関東地方会  594回-  48  -48  2013/02  [Not refereed][Not invited]
  • Changes of immune surveillance in Ewing's sarcoma
    Ryuji Fukuzawa, Hiroki Yabe  東​京​都​病​院​経​営​本​部​臨​床​研​究​報​告​書  2011-  495  -496  2013/01  [Not refereed][Not invited]
  • アダリムマブにより著明な鎮痛効果を認めた脊椎炎合併SAPHO症候群の2例
    矢部 寛樹, 黒岩 卓, 野中 彩, 堤 智美, 桜井 正, 森口 正人, 越智 健介, 寺井 千尋  日本リウマチ学会総会・学術集会・国際リウマチシンポジウムプログラム・抄録集  56回・21回-  623  -623  2012/03  [Not refereed][Not invited]
  • 矢部 寛樹, 塚原 智英, 川口 哲, 和田 卓郎, 鳥越 俊彦, 佐藤 昇志, 黒岩 卓, 寺井 千尋, 青木 正哉, 廣瀬 茂道, 森岡 秀夫, 矢部 啓夫, 福澤 龍二  日本臨床免疫学会会誌  34-  (4)  296  -296  2011/08  [Not refereed][Not invited]

Awards & Honors

  • 2012/10 神奈川整形災害外科研究会 第13回優秀論文賞
     
    受賞者: 矢部 寛樹
  • 2002/11 岩原賞(慶應義塾大学整形外科同窓会・教室)
     
    受賞者: 矢部 寛樹

Research Grants & Projects

  • Ewing肉腫における化学療法前後での免疫応答環境の変化に関する検討
    Date (from‐to) : 2011/04 -2012/03 
    Author : 福澤 龍二

Social Contribution

  • 東日本大震災における災害医療派遣(岩手県立千厩病院)
    Date (from-to) : 2011/11/12-2011/11/25
    Role : Others

Others

  • 2019/12 -2019/12 小児慢性特定疾病指定医
  • 2018/06 -2018/06 OSCE評価者認定講習会修了(四肢と脊柱)
  • 2018/03 -2018/03 身体障害者福祉法第15条指定医(肢体不自由)
  • 2014/11 -2014/11 難病指定医
  • 2011/12 -2011/12 臨床研修指導医講習会修了


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