nakaya takeo

FacultyDeprtmentofPathology(DivisionofhumanPathology)
Job titleAssistant ProfessorWeb site

Profile

Research Keywords

    New Cancer Therapy, Stem cell, KLF5, LMP2A

Research Areas

  • Basic medicine / Experimental pathology
  • Oncology / Tumor biology
  • Pharmacy / Drug development chemistry
  • Basic medicine / Human pathology

Research Activities

Papers(paper)

  • Metastasis of pancreatic cancer within primary colon cancer by overtaking the stromal microenvironment
    Nakaya T, Oshiro H, Saito T, Sakuma Y, Horie H, Sata N, Tanaka A
    Int J Clin Exp Pathol. 11(6) 3141-3146 2018
  • Partial small intestinal resection for successful surgical management of refractory protein-losing gastroenteropathy in systemic lupus erythematosus: A case report and literature review.
    Iwasaki K, Morimoto M, Ota G, Koinuma K, Horie H, Sata N, Nakaya T.
    Medicine 97(30) e11357 2018
  • Giant solitary fibrous tumor of the pleura with high-grade sarcomatous overgrowth accompanied by lipid-rich, rhabdomyosarcomatous, and pleomorphic components: A case report.
    Nakaya T, Oshiro H, Takigami A, Kanai Y, Tetsuka K, Hagiwara K, Fujii H, Endo S, Tanaka A.
    Medicine 96(50) e8926 2017
  • Renal dysplasia characterized by prominent cartilaginous metaplasia lesions in VACTERL association: A case report.
    Nakaya T, Hyuga T, Tanaka Y, Kawai S, Nakai H, Niki T, Tanaka A.
    Medicine 96(15) e6499 2017
  • Cardiac myofibroblast engulfment of dead cells facilitates recovery after myocardial infarction.
    Nakaya M, Watari K, Tajima M, Nakaya T, Matsuda S, Ohara H, Nishihara H, Yamaguchi H, Hashimoto A, Nishida M, Nagasaka A, Horii Y, Ono H, Iribe G, Inoue R, Tsuda M, Inoue K, Tanaka A, Kuroda M, Nagata S, Kurose H.
    J Clin Invest. 127(1) 383-401 2017
  • Ectopic respiratory mucosa in the skin which showed the repetitive distribution of ciliated bronchogenic epithelia and squamous metaplasia.
    Nakano N*, Nakaya T* (*equally contributed), Kamiya K, Komine M, Murata S, Kawata H, Yokoyama S, Tanaka A, Ohtsuki M.
    J Dermatol. 44(11) 1327-1328 2017
  • Stimulation of cellular senescent processes, including secretory phenotypes and anti-oxidant responses, after androgen deprivation therapy in human prostate cancer.
    Kawata H, Kamiakito T, Nakaya T, Komatsubara M, Komatsu K, Morita T, Nagao Y, Tanaka A.
    J Steroid Biochem Mol Biol. 165(Pt B) 219-227 2017
  • Giant seminoma case with very small yolk sac and embryo carcinoma components, detected by intensive histopathological examination.
    Nakaya T, Kobayashi S, Kitahara S, Tanaka A, Komatsu A.
    Hum Pathol.: Case Reports 5 29-33 2016
  • Lymphatic Stomata in the Adult Human Pulmonary Ligament.
    Oshiro H, Miura M, Iobe H, Kudo T, Shimazu Y, Aoba T, Okudela K, Nagahama K, Sakamaki K, Yoshida M, Nagao T, Nakaya T, Kurata A, Ohtani O.
    Lymphat Res Biol. 13(2) 137-145 2015
  • KLF5 regulates the integrity and oncogenicity of intestinal stem cells.
    Nakaya T, Ogawa S, Manabe I, Tanaka M, Sanada M, Sato T, Taketo MM, Nakao K, Clevers H, Fukayama M, Kuroda M, Nagai R.
    Cancer Res. 74(10) 2882-2891 2014
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Papers(paper)close
  • Metastasis of pancreatic cancer within primary colon cancer by overtaking the stromal microenvironment
    Nakaya T, Oshiro H, Saito T, Sakuma Y, Horie H, Sata N, Tanaka A
    Int J Clin Exp Pathol. 11(6) 3141-3146 2018
  • Partial small intestinal resection for successful surgical management of refractory protein-losing gastroenteropathy in systemic lupus erythematosus: A case report and literature review.
    Iwasaki K, Morimoto M, Ota G, Koinuma K, Horie H, Sata N, Nakaya T.
    Medicine 97(30) e11357 2018
  • Giant solitary fibrous tumor of the pleura with high-grade sarcomatous overgrowth accompanied by lipid-rich, rhabdomyosarcomatous, and pleomorphic components: A case report.
    Nakaya T, Oshiro H, Takigami A, Kanai Y, Tetsuka K, Hagiwara K, Fujii H, Endo S, Tanaka A.
    Medicine 96(50) e8926 2017
  • Renal dysplasia characterized by prominent cartilaginous metaplasia lesions in VACTERL association: A case report.
    Nakaya T, Hyuga T, Tanaka Y, Kawai S, Nakai H, Niki T, Tanaka A.
    Medicine 96(15) e6499 2017
  • Cardiac myofibroblast engulfment of dead cells facilitates recovery after myocardial infarction.
    Nakaya M, Watari K, Tajima M, Nakaya T, Matsuda S, Ohara H, Nishihara H, Yamaguchi H, Hashimoto A, Nishida M, Nagasaka A, Horii Y, Ono H, Iribe G, Inoue R, Tsuda M, Inoue K, Tanaka A, Kuroda M, Nagata S, Kurose H.
    J Clin Invest. 127(1) 383-401 2017
  • Ectopic respiratory mucosa in the skin which showed the repetitive distribution of ciliated bronchogenic epithelia and squamous metaplasia.
    Nakano N*, Nakaya T* (*equally contributed), Kamiya K, Komine M, Murata S, Kawata H, Yokoyama S, Tanaka A, Ohtsuki M.
    J Dermatol. 44(11) 1327-1328 2017
  • Stimulation of cellular senescent processes, including secretory phenotypes and anti-oxidant responses, after androgen deprivation therapy in human prostate cancer.
    Kawata H, Kamiakito T, Nakaya T, Komatsubara M, Komatsu K, Morita T, Nagao Y, Tanaka A.
    J Steroid Biochem Mol Biol. 165(Pt B) 219-227 2017
  • Giant seminoma case with very small yolk sac and embryo carcinoma components, detected by intensive histopathological examination.
    Nakaya T, Kobayashi S, Kitahara S, Tanaka A, Komatsu A.
    Hum Pathol.: Case Reports 5 29-33 2016
  • Lymphatic Stomata in the Adult Human Pulmonary Ligament.
    Oshiro H, Miura M, Iobe H, Kudo T, Shimazu Y, Aoba T, Okudela K, Nagahama K, Sakamaki K, Yoshida M, Nagao T, Nakaya T, Kurata A, Ohtani O.
    Lymphat Res Biol. 13(2) 137-145 2015
  • KLF5 regulates the integrity and oncogenicity of intestinal stem cells.
    Nakaya T, Ogawa S, Manabe I, Tanaka M, Sanada M, Sato T, Taketo MM, Nakao K, Clevers H, Fukayama M, Kuroda M, Nagai R.
    Cancer Res. 74(10) 2882-2891 2014
  • Young-age-onset pancreatoduodenal carcinoma in Shwachman-Diamond syndrome.
    Nakaya T, Kurata A, Hashimoto H, Nishimata S, Kashiwagi Y, Fujita K, Kawashima H, Kuroda M.
    Pathol Int. 64(2) 75-80 2014
  • Multifocal kaposiform hemangioendothelioma in multiple visceral organs: an autopsy of 9-day-old female baby.
    Nakaya T, Morita K, Kurata A, Ushiku T, Igarashi T, Kuroda M, Fukayama M.
    Hum Pathol. 45(8) 1773-1777 2014
  • p600 regulates spindle orientation in apical neural progenitors and contributes to neurogenesis in the developing neocortex.
    Belzil C, Asada N, Ishiguro K, Nakaya T, Parsons K, Pendolino V, Neumayer G, Mapelli M, Nakatani Y, Sanada K, Nguyen MD.
    Biol Open. 3(6) 475-485 2014
  • GRK6 deficiency in mice causes autoimmune disease due to impaired apoptotic cell clearance.
    Nakaya M, Tajima M, Kosako H, Nakaya T, Hashimoto A, Watari K, Nishihara H, Ohba M, Komiya S, Tani N, Nishida M, Taniguchi H, Sato Y, Matsumoto M, Tsuda M, Kuroda M, Inoue K, Kurose H.
    Nat Commun. 4 1532 2013
  • Enrichment of stem-like cell population comprises transformation ability of Epstein-Barr virus latent membrane protein 2A for non-transformed cells.
    Nakaya T, Kikuchi Y, Kunita A, Ishikawa S, Matsusaka K, Hino R, Aburatani H, Fukayama M.
    Virus Res. 174(1-2) 108-115 2013
  • p600 Plays Essential Roles in Fetal Development.
    Nakaya T, Ishiguro K, Belzil C, Rietsch AM, Yu Q, Mizuno S, Bronson RT, Geng Y, Nguyen MD, Akashi K, Sicinski P, Nakatani Y.
    PLoS One. 8(6) e66269 2013
  • Activation of DNA methyltransferase 1 by EBV latent membrane protein 2A leads to promoter hypermethylation of PTEN gene in gastric carcinoma.
    Hino R, Uozaki H, Murakami N, Ushiku T, Shinozaki A, Ishikawa S, Morikawa T, Nakaya T, Sakatani T, Takada K, Fukayama M
    Cancer Res. 69(7) 2766-2774 2009
  • Gene induction pathways mediated by distinct IRFs during viral infection.
    Nakaya T, Sato M, Hata N, Asagiri M, Suemori H, Noguchi S, Tanaka N, Taniguchi T
    Biochem Biophys Res Commun. 283(5) 1150-1156 2001
  • Distinct and essential roles of transcription factors IRF-3 and IRF-7 in response to viruses for IFN-alpha/beta gene induction.
    Sato M, Suemori H, Hata N, Asagiri M, Ogasawara K, Nakao K, Nakaya T, Katsuki M, Noguchi S, Tanaka N, Taniguchi T
    Immunity 13(4) 539-548 2000
  • Positive feedback regulation of type I IFN genes by the IFN-inducible transcription factor IRF-7.
    Sato M, Hata N, Asagiri M, Nakaya T, Taniguchi T, Tanaka N
    FEBS Lett. 441(1) 106-110 1998

Conference Presentations

  • Small molecules mimicking KLF5 structure suppresses cancer cells in both in vivo and vitro without damaging normal cells.
    Nakaya T, Tsuji K, Tanaka A, Nagai R.
    6th International Conference on Biology and Pathobiology of KLF/Sp Transcription Factors 30 Oct. 2018
  • Small mimicries of KLF5 selectively suppress the survival and Wnt-KLF5 signal of colorectal cancer.
    Nakaya T, Kasai M, Nakano H, Yoshimori A, Tanaka A, Kouji H, Nagai R.
    29 Apr. 2017
  • The protein interaction inhibitors of KLF5 suppress Wnt signal activation selectively in colorectal cancer cells.
    Nakaya T, Nakano H, Kasai M, Yoshimori A, Tanaka A, Kouji H, Nagai R
    06 Oct. 2016
  • The protein interaction inhibitors of KLF5 suppress Wnt signal activation selectively in colorectal cancer cells.
    Nakaya T, Nagai R
    FASEB SRC, KLF and SP Transcription Factors In Disease And Regenerative Medicine Aug. 2016
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Conference Presentationsclose
  • Small molecules mimicking KLF5 structure suppresses cancer cells in both in vivo and vitro without damaging normal cells.
    Nakaya T, Tsuji K, Tanaka A, Nagai R.
    6th International Conference on Biology and Pathobiology of KLF/Sp Transcription Factors 30 Oct. 2018
  • Small mimicries of KLF5 selectively suppress the survival and Wnt-KLF5 signal of colorectal cancer.
    Nakaya T, Kasai M, Nakano H, Yoshimori A, Tanaka A, Kouji H, Nagai R.
    29 Apr. 2017
  • The protein interaction inhibitors of KLF5 suppress Wnt signal activation selectively in colorectal cancer cells.
    Nakaya T, Nakano H, Kasai M, Yoshimori A, Tanaka A, Kouji H, Nagai R
    06 Oct. 2016
  • The protein interaction inhibitors of KLF5 suppress Wnt signal activation selectively in colorectal cancer cells.
    Nakaya T, Nagai R
    FASEB SRC, KLF and SP Transcription Factors In Disease And Regenerative Medicine Aug. 2016

Book

  • Precision Medicine
    Takeo Nakaya(Contributor )
    Dec. 2018
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Bookclose
  • Precision Medicine
    Takeo Nakaya(Contributor )
    Dec. 2018


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