Researchers Database

yamashita takeshi

    ComprehensiveMedicine1 Research Associate
Last Updated :2021/10/19

Researcher Information

Alias Name

    Takeshi Yamashita

J-Global ID

Research Areas

  • Life sciences / Internal medicine - General

Academic & Professional Experience

  • 2018/04 - Today  Jichi Medical University Saitama Medical CenterDepartment of General Medicine助教
  • 2015/12 - 2018/03  Jichi Medical University Saitama Medical CenterDepartment of General Medicine病院助教
  • 2012/05 - 2015/11  Jichi Medical University Saitama Medical CenterDepartment of General Medicinesenior regident
  • 2011/04 - 2012/03  Iwate Medical University脳神経外科学医員
  • 2009/04 - 2011/03  Iwate Medical University初期臨床研修医


  • 2009/04 - 2014/03  Iwate Medical University  医学部  医学科
  • 2002/04 - 2009/03  Iwate Medical University  School of Medicine

Association Memberships


Published Papers

  • Takeshi Yamashita, Masashi Yoshida, Hodaka Yamada, Tomoko Asano, Atsushi Aoki, Aki Ikoma, Ikuyo Kusaka, Masafumi Kakei, San-e Ishikawa
    INTERNAL MEDICINE 53 (8) 845 - 849 0918-2918 2014 [Refereed][Not invited]
    A 78-year-old man with abdominal pain was diagnosed with a rupture of a gastric artery aneurysm. The serum Na level promptly decreased from 135 to 110 mmol/L within several days. Brain magnetic resonance angiography revealed severe vasoconstriction of the cerebral basilar artery and anterior cerebral artery. There was neither dehydration nor edema. The plasma arginine vasopressin level was 3.3 pg/mL, despite hypoos-molality. These findings indicated a diagnosis of syndrome of inappropriate secretion of antidiuretic hormone (SIADH) derived from severe vasoconstriction of the cerebral arteries. The administration of 7.5 mg of tolvaptan rapidly increased the serum Na level from 123 to 138 mmol/L within the first 24 hours, thereafter continuously maintaining a normal level. Treatment with tolvaptan corrected the patient's dilutional hyponatremia.
  • Takeshi Yamashita, Kuniaki Ogasawara, Hiroki Kuroda, Taro Suzuki, Kohei Chida, Masakazu Kobayashi, Kenji Yoshida, Yoshitaka Kubo, Akira Ogawa
    CLINICAL NUCLEAR MEDICINE 37 (2) 128 - 133 0363-9762 2012/02 [Refereed][Not invited]
    Purpose: The purpose of the present study was to determine whether preoperative cerebral blood flow (CBF) or cortical central benzodiazepine receptor binding potential as measured by brain perfusion or I-123-iomazenil (IMZ) single-photon emission computed tomography (SPECT) imaging, respectively, can predict cognitive improvement after uncomplicated carotid endarterectomy (CEA). Methods: Neuropsychological testing was performed preoperatively and after 1 month postoperatively in 140 patients who underwent CEA for unilateral internal carotid artery (ICA) stenosis (>= 70%). Brain perfusion SPECT using N-isopropyl-p-[I-123]-iodoamphetamine and IMZ SPECT was also performed before surgery. SPECT data were analyzed using a 3-dimensional stereotaxic region-of-interest template. Results: Fourteen patients (10%) showed improved cognitive function postoperatively. Logistic regression analysis demonstrated that, among the variables tested, low relative CBF in the cerebral hemisphere ipsilateral to surgery was significantly associated with postoperative cognitive improvement (95% confidence interval: 0.623-0.868; P = 0.0003). The combination of reduced relative CBF and moderately reduced relative uptake of IMZ identified development of postoperative cognitive improvement with 100.0% sensitivity, 84.9% specificity, a positive predictive value of 42.4%, and a negative predictive value of 100%. Further, in a subgroup of patients with reduced relative CBF and moderately reduced relative uptake of IMZ, the difference between these 2 values was significantly greater in patients with postoperative cognitive improvement than in those without (P < 0.0001). Conclusions: The combination of preoperative CBF and cortical central benzodiazepine receptor binding potential as determined by SPECT can predict cognitive improvement after CEA.

Books etc

  • 総合診療力を磨く40の症候・症例カンファレンス
    山下 武志 (Contributor症例15)
    南江堂 2014/04

Conference Activities & Talks

  • 神経性食思不振症による低血糖、ショックの治療中にカテーテル関連血流感染による感染性心内膜炎および真菌血症を併発した1例  [Not invited]
    山下 武志
    第68回日本感染症学会東日本地方会  2019/10
  • 副鼻腔炎から生じた肺炎球菌性髄膜炎、心内膜炎の一例  [Not invited]
    山下 武志
    第67回日本感染症学会東日本地方会  2018/10
  • A Case of Acute Syphilitic Meningitis Diagnosed from Syphilis Blood Tests as Pre-exam for the Screening of Bloody Stools by Colonoscopy  [Not invited]
    Takeshi Yamashita
    ACP JAPAN 2018  2018/06
  • 副鼻腔炎から細菌性髄膜炎を発症し、左外転神経麻痺を生じた1例  [Not invited]
    山下 武志
    第6回日本プライマリ・ケア連合学会関東地方会  2017/11
  • 高齢発症の抗内因子抗体陽性ビタミンB12欠乏性神経障害をビタミンB12経口薬で治療し得た2例  [Not invited]
    山下 武志
    第114回日本内科学会総会  2017/04
  • 急性肺炎による呼吸不全が筋強直性ジストロフィーの診断契機となった2例  [Not invited]
    山下 武志
    第113回日本内科学会総会  2016/04
  • 腰椎圧迫骨折を契機に診断し得たKlinefelter症候群の一例  [Not invited]
    山下 武志
    第618回日本内科学会関東地方会  2015/10
  • 胃動脈瘤破裂後にSIADHを来した1例  [Not invited]
    山下 武志
    第22回臨床内分泌代謝Update  2013/01
  • Combination of preoperative cerebral blood flow and 123I-iomazenil SPECT imaging predicts postoperative cognitive improvement in patients undergoing uncomplicated endarterectomy for unilateral carotid stenosis.  [Not invited]
    Takeshi Yamashita
    The 5th Japanese-Korean Joint Stroke Conference  2011/11
  • 頸椎前方除圧固定術後に発症したBow-Hunter症候群の一例  [Not invited]
    山下 武志
    第47回日本脳神経外科学会東北支部会  2011/09

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