Researchers Database

sata naohiro

    Director of Jichi Medical University Hospital Director of Jichi Medical University Hospital
Last Updated :2021/11/23

Researcher Information

Degree

  • MD(PhD)

J-Global ID

Research Interests

  • 内視鏡外科   肝胆膵外科   消化器外科   一般外科   Gastroenterological Surgery   General Surgery   

Research Areas

  • Life sciences / Digestive surgery
  • Life sciences / General surgery, pediatric surgery

Academic & Professional Experience

  • 2003/08 - 2007/09  Jichi Medical UniversityDepartment of SurgeryAssociate Professor
  • 2000/04 - 2003/07  Jichi Medical UniversityDepartment of SurgeryLecturer
  • 2000 - 2002  Lecture (Assistant Professor), Faculty of
  • 1994/01 - 1996/09  University of Tokyo1st. Department of SurgeryAssistant Professor
  • 1994 - 1996  Assistant Professor, Faculty of Medicine,
  • Medicine, Jichi Medical School
  • University of Tokyo
  • Jichi Medical UniversityProfessor

Education

  •        - 1984  The University of Tokyo  Faculty of Medicine  School of Medicine
  •        - 1984  The University of Tokyo  Faculty of Medicine

Association Memberships

  • 日本臨床外科学会   日本肝胆膵外科学会   American Gastroenterological Association   日本内視鏡外科学会   日本消化器内視鏡学会   日本消化器外科学会   日本胆道学会   日本膵臓学会   日本消化器病学会   日本外科学会   

Published Papers

  • Daishi Naoi, Hisanaga Horie, Koji Koinuma, Yuko Kumagai, Gaku Ota, Mineyuki Tojo, Yuji Kaneda, Shuji Hishikawa, Ai Sadatomo, Yoshiyuki Inoue, Noriyoshi Fukushima, Alan Kawarai Lefor, Naohiro Sata
    Surgery today 51 (10) 1713 - 1719 2021/10 
    PURPOSE: The aim of this study was to evaluate both the intestinal mucosa staple line integrity and anastomotic leak pressure after healing in a porcine survival model. METHODS: We used two suture models using two different size staples (incomplete mucosal closure model: group G [staple height 0.75 mm], complete mucosal closure model: group B [staple height 1.5 mm]) in the porcine ileum. Five staple lines were created in each group made in the ileum for each model, and the staple sites harvested on days 0, 2, and 7. The leak pressure at the staple site was measured at each time point. RESULTS: On day 0, the leak pressure for group G (79.5 mmHg) was significantly lower than that for group B (182.3 mmHg) (p < 0.01). On days 2 and 7, there was no significant difference between groups G and B (171 mmHg and 175.5 mmHg on day 2, 175.5 mmHg and 175.5 mmHg on day 7, p > 0.05). The histological findings in both groups showed similar healing at postoperative days 2 and 7. CONCLUSION: The integrity of the mucosal staple lines was associated with the postoperative leak pressure on day 0. However, there was no association with the leak pressure at two days or more postoperatively in a porcine model.
  • Yuji Kaneda, Yuki Kimura, Akira Saito, Hideyuki Ohzawa, Ryusuke Ae, Hiroshi Kawahira, Alan K Lefor, Naohiro Sata
    Cureus 13 (9) e18238  2021/09 
    Introduction Although new techniques and devices have been introduced, the incidence of postoperative pancreatic fistula (POPF) after distal pancreatectomy remains high. To reduce the risk of POPF, we developed an innovative ligation band and conducted this pilot study to assess the possibility of reducing the incidence of POPF and pancreatic necrosis after distal pancreatectomy. Methods Distal pancreatectomy was performed in three pigs. In two animals, ligation of the pancreas was performed while maintaining arterial blood flow to the stump, and in one animal, the arterial blood flow was occluded. After ligation, the pancreas was sharply divided. Animals were sacrificed seven days later, and the remnant pancreas was assessed histologically. POPF was defined as amylase in ascites > 3x the preoperative serum amylase level. The following equation was used to quantify the extent of necrotic tissue: necrotic tissue residual rate = necrotic tissue area/ cross-sectional area. Results All animals survived, and no POPF developed. For two animals in which arterial blood flow to the stump was maintained, necrotic tissue residual rates at the ligation line were 24% and 31%. At the pancreatic stump, necrotic tissue residual rates were 37% and 50%. In the animal in which arterial blood flow to the stump was occluded, the necrotic tissue residual rate at the ligation line was 83% and that at the pancreatic stump was 78%, both higher than that in animals in which arterial blood flow was maintained. In all animals, there was no injury to pancreatic tissue at the ligation line. Conclusion The pancreas ligation band can potentially prevent POPF after distal pancreatectomy by atraumatic ligation, and the band ligates the pancreatic stump while maintaining arterial blood flow and limiting pancreatic necrosis.
  • Toru Takagi, Shin Saito, Shinichiro Yokota, Yuki Kaneko, Kazuya Takahashi, Rihito Kanamaru, Kentaro Kurashina, Yoshinori Hosoya, Joji Kitayama, Hirotoshi Kawata, Hiroyuki Osawa, Naohiro Sata
    Surgical case reports 7 (1) 146 - 146 2021/06 
    BACKGROUND: Leiomyosarcoma is a rare tumor that could originate from the gastrointestinal tract, uterus, kidney, retroperitoneum, and the soft tissues of the extremities. It accounts for only 1% of all gastrointestinal mesenchymal tumors and primary leiomyosarcoma of the stomach is extremely rare. Most cases reported as leiomyosarcoma of the stomach before the development of KIT immunohistochemistry might be gastrointestinal stromal tumors (GISTs) of the stomach and only 18 cases of leiomyosarcoma of the stomach have been reported since early 2000s. We report here a patient with leiomyosarcoma of the stomach treated by laparoscopic and endoscopic cooperative surgery (LECS). CASE PRESENTATION: A 59-year-old man was referred to our hospital for an early gastric cancer, which was initially treated by endoscopic submucosal dissection. Six months after his initial treatment, a follow-up esophagogastroduodenoscopy revealed a small polypoid lesion at the lesser curvature of the proximal stomach, which appeared to be a hyperplastic polyp. However, one and a half years later, the lesion grew and showed more irregular surface. Biopsy at the time revealed smooth muscle cell proliferation suggestive of leiomyoma. Three years later, the lesion grew even larger and biopsy showed pleomorphic spindle cells. Immunohistochemical study showed positive staining for alpha-smooth muscle actin and desmin, but negative for c-kit and CD34. Ki-67 labeling index was nearly 60%. Based on these findings, the diagnosis of leiomyosarcoma was established. The patient subsequently underwent a partial gastrectomy by LECS. The patient is currently in good condition without recurrence or metastasis at 12 months after surgery. CONCLUSIONS: Leiomyosarcoma of the stomach is extremely rare. This is the first report of leiomyosarcoma of the stomach treated by LECS. We could also follow its appearance change through endoscopic examination for 3 years.
  • Yukihiro Sanada, Yasunaru Sakuma, Yasuharu Onishi, Noriki Okada, Naoya Yamada, Yuta Hirata, Go Miyahara, Takumi Katano, Toshio Horiuchi, Takahiko Omameuda, Keiko Ogaki, Shinya Otomo, Alan Kawarai Lefor, Naohiro Sata
    Pediatric transplantation 25 (4) e13997  2021/06 
    BACKGROUND: Complications associated with ultrasonographically guided percutaneous transhepatic liver biopsy (PTLB) after liver transplantation (LT) have been rarely reported, and there is no consensus about its safety. We retrospectively reviewed the safety and outcomes of PTLB after pediatric LT. METHODS: Between January 2008 and December 2019, 8/1122 (0.71%) pediatric patients who underwent ultrasonographically guided PTLB after LT developed complications. The median age at PTLB was 7.8 years (range 0.1-17.9). Grafts included left lobe/left lateral segment in 1050 patients and others in 72. PTLB was performed using local anesthesia±sedation in 1028 patients and general anesthesia in 94. RESULTS: Complications after PTLB included acute cholangitis in 3 patients, sepsis in 2, respiratory failure due to over-sedation in 1, subcapsular hematoma in 1, and intrahepatic arterioportal fistula in 1. The incidence of complications of PTLB in patients with biopsy alone and those with simultaneous interventions was 0.49% and 3.19%, respectively (p = .023). Patients who developed acute cholangitis, respiratory failure, subcapsular hematoma, and arterioportal fistula improved with non-operative management. Of two patients with sepsis, one underwent PTLB and percutaneous transhepatic portal vein balloon dilatation and developed fever and seizures the following day. Sepsis was treated with antibiotic therapy. Another patient who underwent PTLB and exchange of percutaneous transhepatic biliary drainage catheter developed fever and impaired consciousness immediately. Sepsis was treated with antibiotic therapy, mechanical ventilation, and continuous hemofiltration. CONCLUSIONS: Percutaneous transhepatic liver biopsy after pediatric LT is safe. However, combining liver biopsy with simultaneous procedures for vascular and biliary complications is associated with an increased risk of complications.
  • Keiko Yamaoka, Shuichi Nagashima, Nobukazu Okada, Nagisa Sawayama, Shinsuke Saito, Manabu Takahashi, Kenta Okada, Kazuhiro Endo, Masaru Koizumi, Hideki Sasanuma, Ken Ebihara, Atsuko Kasajima, Noriyoshi Fukushima, Naohiro Sata, Shun Ishibashi
    Clinical case reports 9 (5) e04118  2021/05 
    Long-acting somatostatin analogs, including lanreotide slow release (LAN-SR) and octreotide long-acting release (OCT-LAR), can improve hypoglycemia in insulinoma. LAN-SR may be more beneficial in some patients with insulinoma than OCT-LAR.
  • Noriki Okada, Yuta Kawahara, Yukihiro Sanada, Yuta Hirata, Shinya Otomo, Hitomi Niijima, Akira Tanaka, Akira Morimoto, Alan K Lefor, Taizen Urahashi, Yoshikazu Yasuda, Koichi Mizuta, Yasunaru Sakuma, Naohiro Sata
    American journal of transplantation : official journal of the American Society of Transplantation and the American Society of Transplant Surgeons 2021/04 
    Maternal T cells from perinatal transplacental passage have been identified in up to 40% of patients with severe combined immunodeficiency (SCID). Although engrafted maternal T cells sometimes injure newborn tissue, liver failure due to maternal T cells has not been reported. We rescued a boy with X-linked SCID who developed liver failure due to engrafted maternal T cell invasion following living donor liver transplantation (LDLT) following unrelated umbilical cord blood transplantation (UCBT). After developing respiratory failure 3 weeks postpartum, he was diagnosed with X-linked SCID. Pathological findings showed maternal T cells engrafted in his liver and hepatic fibrosis gradually progressed. He underwent UCBT at 6 months, but hepatic function did not recover and liver failure progressed. Therefore, he underwent LDLT using an S2 monosegment graft at age 1.3 years. The patient had a leak at the Roux-en-Y anastomosis, which was repaired. Despite occasional episodes of pneumonia and otitis media, he is generally doing well 6 years after LDLT with continued immunosuppression agents. In conclusion, the combination of hematopoietic stem cell transplantation (HSCT) and liver transplantation may be efficacious, and HSCT should precede liver transplantation for children with X-linked SCID and liver failure.
  • Kenichi Oshiro, Kazuhiro Endo, Kazue Morishima, Yuji Kaneda, Masaru Koizumi, Hideki Sasanuma, Yasunaru Sakuma, Alan Kawarai Lefor, Naohiro Sata
    BMC surgery 21 (1) 102 - 102 2021/02 
    BACKGROUND: Pancreatojejunostomy (PJ) is one of the most difficult and challenging abdominal surgical procedures. There are no appropriate training systems available outside the operating room (OR). We developed a structured program for teaching PJ outside the OR. We describe its development and results of a pilot study. METHODS: We have created this structured program to help surgical residents and fellows acquire both didactic knowledge and technical skills to perform PJ. A manual was created to provide general knowledge about PJ and the specific PJ procedure used in our institution. Based on questionnaires completed by trainers and trainees, the procedure for PJ was divided into twelve steps and described in detail. After creating the manual, we developed organ models, needles and a frame box for simulation training. Three residents (PGY3-5) and three fellows (PGY6 or above) participated in a pilot study. Objective and subjective evaluations were performed. RESULTS: Trainees learn about PJ by reading the procedure manual, acquiring both general and specific knowledge. We conducted simulation training outside the OR using the training materials created for this system. They simulate the procedure with surgical instruments as both primary and assistant surgeon. In this pilot study, as objective assessments, the fellow-group took less time to complete one anastomosis (36 min vs 48 min) and had higher scores in the objective structured assessment of technical skill (average score: 4.1 vs 2.0) compared to the resident-group. As a subjective assessment, the confidence to perform a PJ anastomosis increased after simulation training (from 1.6 to 2.6). Participants considered that this structured teaching program is useful. CONCLUSION: We developed a structured program for teaching PJ. By implementing this program, learning opportunities for surgical residents and fellows can be increased as a complement to training in the OR.
  • Daishi Naoi, Koji Koinuma, Hideki Sasanuma, Yasunaru Sakuma, Hisanaga Horie, Alan Kawarai Lefor, Kokichi Sugano, Mineko Ushiama, Teruhiko Yoshida, Naohiro Sata
    Surgical case reports 7 (1) 35 - 35 2021/01 
    BACKGROUND: Familial adenomatous polyposis (FAP) is characterized by the presence of hundreds to thousands of colonic polyps, and extracolonic manifestations are likely to occur. Pancreatic tumors are rare extracolonic manifestations in patients with FAP, among which solid-pseudopapillary neoplasm (SPN) are extremely rare. We report here a patient with an SPN of the pancreas found during the follow-up of FAP. CASE PRESENTATION: A 20-year-old woman was diagnosed with FAP 3 years previously by colonoscopy which revealed less than 100 colonic polyps within the entire colon. She complained of left upper abdominal pain and a 10-cm solid and cystic pancreatic tumor was found by computed tomography scan. Solid and cystic components within the tumor were seen on abdominal magnetic resonance imaging. Simultaneous laparoscopic resection of the distal pancreas and subtotal colectomy was performed. Histopathological findings confirmed the pancreatic tumor as an SPN without malignancy. Abnormal staining of beta-catenin was observed by immunohistochemical study. Multiple polyps in the colorectum were not malignant. Molecular biological analysis from peripheral blood samples revealed a decrease in the copy number of the promoter 1A and 1B region of the APC gene, which resulted in decreased expression of the APC gene. CONCLUSIONS: A rare association of SPN with FAP is reported. The genetic background with relation to beta-catenin abnormalities is interesting to consider tumor development. So far, there are few reports of SPN in a patient with FAP. Both lesions were treated simultaneously by laparoscopic resection.
  • Joji Kitayama, Shin Saito, Hironori Yamaguchi, Alan Kawarai Lefor, Hironori Ishigami, Naohiro Sata
    Annals of surgical oncology 2021/01
  • Yoshikazu Asada, Hitoaki Okazaki, Naohiro Sata, Hiroshi Kawahira, Shinichi Yamamoto, Yasushi Matsuyama
    International Journal of Institutional Research and Management 5 (1) 30 - 44 2432-3675 2021
  • Kanako Omata, Noriki Okada, Go Miyahara, Yuta Hirata, Yukihiro Sanada, Yasuharu Onishi, Shinya Fukuda, Hideki Kumagai, Alan Kawarai Lefor, Yasunaru Sakuma, Naohiro Sata
    Transplantation Proceedings 0041-1345 2021/01
  • Akira Saito, Mineyuki Tojo, Yuko Kumagai, Hideyuki Ohzawa, Hironori Yamaguchi, Hideyo Miyato, Ai Sadatomo, Daishi Naoi, Gaku Ota, Koji Koinuma, Hisanaga Horie, Alan Kawarai Lefor, Naohiro Sata, Joji Kitayama
    Heliyon 7 (1) e05880  2021/01 
    Aim: PD-1/PD-L1 blockade therapy is now widely used for the treatment of advanced malignancies. Although PD-L1 is known to be expressed by various host cells as well as tumor cells, the role of PD-L1 on non-malignant cells and its clinical significance is unknown. We evaluated cell type-specific expression of PD-L1 in colorectal cancer (CRC) specimens using multicolor flow cytometry. Methods: Single cell suspensions were made from 21 surgically resected CRC specimens, and immunostained with various mAbs conjugated with different fluorescent dyes. Tumor cells, stromal cells, and immune cells were identified as CD326(+), CD90(+) and CD45(+) phenotype, respectively. CD11b(+) myeloid cells, CD19(+) B cells and CD4(+) or CD8(+) T cells were also stained in different samples, and their frequencies in the total cell population and the ratio of PD-L1(+) cells to each phenotype were determined. Results: PD-L1 was expressed by all the cell types. The ratio of PD-L1(+) cells to CD326(+) tumor cells was 19.1% ± 14.0%, lower than those for CD90(+) stromal cells (39.6% ± 16.0%) and CD11b(+) myeloid cells (31.9% ± 14.3%). The ratio of PD-L1(+) cells in tumor cells correlated strongly with the ratio in stromal cells, while only weakly with that in myeloid cells. Tumor cells were divided into two populations by CD326 expression levels, and the PD-L1 positive ratios were inversely correlated with the rate of CD326 highly expressing cells as well as mean fluorescein intensity of CD326 in tumor cells, while positively correlated with the frequencies of stromal cells or myeloid cells in CRC. Conclusion: PD-L1 is differentially expressed on various cell types in CRC. PD-L1 on tumor cells may be upregulated together with CD326 downregulation in the process of epithelial mesenchymal transition. Quantification of cell type-specific expression of PD-L1 using multicolor flow cytometry may provide useful information for the immunotherapy of solid tumors.
  • Kazuya Takahashi, Kentaro Kurashina, Shin Saito, Rihito Kanamaru, Hideyuki Ohzawa, Hironori Yamaguchi, Hideyo Miyato, Yoshinori Hosoya, Alan Kawarai Lefor, Naohiro Sata, Joji Kitayama
    Cytometry. Part B, Clinical cytometry 2020/12 
    BACKGROUND: The frequency of tumor cell dissemination in the peritoneal cavity is critically related to the progression of peritoneal metastases (PM). Recently, flow cytometry (FCM) has been successfully used to detect tumor cells in malignant effusions. METHODS: A total of 143 single cell suspensions derived from ascites or peritoneal lavages from patients with advanced gastric cancer (GC) were stained with monoclonal antibodies to CD45 and to CD326 as well as 4,6-diamidino-2-phenylindole (DAPI) and FVS780. Using FCM, tumor-leukocyte ratio (TLR) were calculated from CD45(-)CD326(+) tumor cell counts/ CD45(+)CD326(+) leukocyte counts in DAPI (+) FVS780(-) gated area. In 54 patients, the ratios of CD11b(+), CD4(+) and CD8(+) cells in CD45(+) leukocytes were evaluated in parallel. RESULTS: TLR of 69 patients with PM were significantly higher than those of 74 without PM (p < .001) and log(TLR) showed strong correlation with peritoneal cancer index scores in 51 PM (+) patients (r = 0.439). TLR in PM (+) patients also correlated with the ratio of CD11b (+) myeloid cells (r = 0.547), and correlated inversely with those of CD4(+) (r = -0.490) and CD8(+) T cells (r = -0.648). In PM (-) patients who underwent gastrectomy, TLR never exceeded 0.1% in patients with primary GC without serosal involvement (
  • Shin Saito, Hironori Yamaguchi, Hideyuki Ohzawa, Hideyo Miyato, Rihito Kanamaru, Kentaro Kurashina, Yoshinori Hosoya, Alan Kawarai Lefor, Naohiro Sata, Joji Kitayama
    Annals of surgical oncology 2020/12 
    BACKGROUND: Intraperitoneal (IP) administration of paclitaxel (PTX) has a great pharmacokinetic advantage to control peritoneal lesions and can be combined with various systemic chemotherapies. In this study, we evaluate the efficacy and tolerability of a combination of IP-PTX and systemic S-1/oxaliplatin (SOX) for induction chemotherapy for patients with peritoneal metastases (PM) from gastric cancer (GC). PATIENTS AND METHODS: Patients with GC who were diagnosed as macroscopic PM (P1) or positive peritoneal cytology (CY1) by staging laparoscopy between 2016 and 2019 were enrolled. PTX was IP administered at 40 mg/m2 on days 1 and 8. Oxaliplatin was IV administered at 100 mg/m2 on day 1, and S-1 was administered at 80 mg/m2/day for 14 consecutive days, repeated every 21 days. Survival time and toxicities were retrospectively explored. RESULTS: Forty-four patients received SOX + IP-PTX with a median (range) of 16 (1-48) courses, although oxaliplatin was suspended due to the hematotoxicity or intolerable peripheral neuropathy in many patients. The 1-year overall survival (OS) rate was 79.5% (95% CI 64.4-88.8%) with median survival time of 25.8 months. Gastrectomy was performed in 20 (45%) patients who showed macroscopic shrinkage of PM with a 1-year OS rate of 100% (95% CI 69.5-100%). Grade 2 and 3 histological responses was achieved in four (20%) and one (5%) patients. Grade 3/4 toxicities included neutropenia (11%), leukopenia (39%), and anemia (14%). There were no treatment-related deaths. CONCLUSIONS: Combination chemotherapy using SOX + IP-PTX regimen is highly effective and recommended as induction chemotherapy for patients with PM from GC.
  • Atsushi Shimizu, Alan Kawarai Lefor, Yasuko Noda, Naohiro Sata
    Surgical and radiologic anatomy : SRA 42 (12) 1485 - 1488 2020/12 
    BACKGROUND: Communicating accessory bile ducts are defined as ducts that communicate between major biliary channels but do not drain individual segments of the liver. The Couinaud Type A communicating accessory bile duct is a rare anomaly where an aberrant duct connects the right main hepatic duct to the common hepatic duct without segmental drainage. There are very few reports of this anomaly in the literature to date. CASE PRESENTATION: A 75-year-old male who died of ischemic heart disease donated his body for cadaveric dissection, which included careful attention to the anatomy of the hepatic hilum. During dissection, it was found that the right hepatic duct was duplicated and an accessory duct drained directly into the common hepatic duct. Although rare and difficult to visualize even with modern preoperative imaging techniques, sound knowledge of this rare anatomic variation is imperative to avoid inadvertent intraoperative biliary injuries which can lead to severe morbidity. CONCLUSIONS: An aberrant bile duct from the right hepatic duct to the common hepatic duct (Couinaud Type A) is an uncommon accessory bile duct that one must be aware of when performing complex hepatobiliary procedures such as right liver resection for living-related donation. Detailed preoperative imaging and careful dissection with anticipation of anomalous anatomy are of the utmost importance for the safe conduct of hepatic surgery.
  • Hideyuki Ohzawa, Yuki Kimura, Akira Saito, Hironori Yamaguchi, Hideyo Miyato, Yasunaru Sakuma, Hisanaga Horie, Yoshinori Hosoya, Alan Kawarai Lefor, Naohiro Sata, Joji Kitayama
    Annals of surgical oncology 27 (13) 5057 - 5064 2020/12 
    BACKGROUND: Repeat intraperitoneal (IP) chemotherapy has been successfully used for treatment of peritoneal metastases (PM) from gastric cancer (GC). Exosomes play important roles not only in tumor progression but also in chemoresistance via transfer of microRNAs (miRNAs). However, there is little evidence of an effect of miRNAs in peritoneal exosomes on chemosensitivity of peritoneal lesions. METHODS: In 74 patients with advanced GC who underwent staging laparoscopy, exosomes were isolated from peritoneal fluid and expression levels of miR-21-5p, miR-223-3p, and miR-29b-3p determined using TaqMan Advanced miRNA assays. In 43 patients with PM treated with combination chemotherapy, S-1 plus Oxaliplatin together with IP Paclitaxel, the relationship between their relative expression levels and outcomes was examined. RESULTS: The ratios of miR-21-5p/miR-29b-3p and miR-223-3p/miR-29b-3p were significantly upregulated in patients with PM, especially in patients with high serum CA125 levels. They showed a mild association with Peritoneal Cancer Index (PCI) score and ascites. More impressively, the ratios were significantly higher in 16 patients with progression of PM within 1 year compared with 27 patients with an excellent tumor response (miR-21-5p/miR-29b-3p: median 17.49, range 1.83-50.90 vs. median 4.64, range 0.40-38.96, p = 0.0015, miR-223-3p/miR-29b-3p: median 1.02, range 0.23-25.85 vs. median 0.21, range 0.01-50.07, p = 0.0006). Overall survival of patients with high miR-21/miR-29b or miR-223/miR-29b ratios was significantly worse than in patients with low ratios (p = 0.0117, p = 0.0021). CONCLUSIONS: The ratios of miRNAs in peritoneal exosome correlate with survival of the patients with PM from GC and suggest the possibility that they modify the chemosensitivity against IP chemotherapy.
  • Masanao Kurata, Yukio Iwashita, Tetsuji Ohyama, Itaru Endo, Taizo Hibi, Akiko Umezawa, Kenji Suzuki, Manabu Watanabe, Koji Asai, Yasuhisa Mori, Masaharu Higashida, Yusuke Kumamoto, Junichi Shindoh, Masahiro Yoshida, Goro Honda, Takeyuki Misawa, Yuta Abe, Yuichi Nagakawa, Naoyuki Toyota, Shigetoshi Yamada, Shinji Norimizu, Naoki Matsumura, Naohiro Sata, Hiroki Sunagawa, Masahiro Ito, Yutaka Takeda, Yoshiharu Nakamura, Toshiki Rikiyama, Ryota Higuchi, Takeshi Gocho, Kimihiko Ueno, Yuko Kumagai, Shingo Kanaji, Tadahiro Takada, Masakazu Yamamoto
    Journal of hepato-biliary-pancreatic sciences 28 (3) 255 - 262 2020/12 
    BACKGROUND: To explore best practices for acute cholecystitis, it is necessary to construct a system to assess the difficulty of laparoscopic cholecystectomy (LC) based on intraoperative findings. In this study, multiple evaluators assessed videos of LC to assemble a library of typical video clips for 25 intraoperative findings. METHODS: We have previously identified 25 items that contribute to surgical difficulty in LC. For each item, roughly 30-s video clips were submitted from videos of LC performed at member institutions. We then selected one typical video from the collected clips based on simple tabulation of the instances of agreement. Inter-rater agreement was assessed with Fleiss's κ and Gwet's agreement coefficient (AC). RESULTS: Except in the case of two assessment items ("edematous change" and "easy bleeding"), κ or AC significantly exceeded 0.5 and the typical videos were judged to be applicable. For the two remaining items, the evaluation was repeated after clarifying the definitions of positive and negative findings. Eventually, they were recognized as typical. The completed video clip library contains 31 clips and is divided into five categories (http://www.jshbps.jp/modules/project/index.php?content_id=13). CONCLUSIONS: This clip library may be highly useful in clinical settings as a more objective standard for assessing surgical difficulty in LC.
  • Akira Saito, Joji Kitayama, Hisanaga Horie, Koji Koinuma, Hideyuki Ohzawa, Hironori Yamaguchi, Hiroshi Kawahira, Toshiki Mimura, Alan Kawarai Lefor, Naohiro Sata
    Cancer science 111 (11) 4012 - 4020 2020/11 
    Accumulating evidence suggests that metformin reduces the incidence and mortality of colorectal cancer (CRC). However, underlying mechanisms have not been fully clarified. The aim of this study was to examine the pathological characteristics of resected CRC from patients treated with metformin for type 2 diabetes mellitus (DM). In total, 267 patients with DM underwent curative colectomy for Stage I-III CRC and 53 (19.9%) patients had been treated medically including metformin. Pathological N-stage was significantly lower in metformin-treated patients (P < .05) with prolonged disease-free survival (DFS) (P < .05). Immunohistochemistry showed that the densities of CD3(+) and CD8(+) tumor-infiltrating lymphocytes (TILs) in the invasive front area were significantly higher in 40 patients treated with metformin compared with propensity score matched cases without metformin (P < .05). The density of tertiary lymphoid structures (TLS) in tumor stroma was markedly increased in metformin-treated patients (P < .001). In those tumors, there were more CD68(+) tumor-associated macrophages (TAM) infiltrated (P < .05), while the ratio of CD163(+) M2-phenotype was markedly reduced (P < .001). Stromal fibrosis tended to be suppressed by metformin intake (P = .051). These findings suggested that metformin drastically changes the characteristics of infiltrating immune cells in CRC and reprograms the tumor microenvironment from immunosuppressive to immunocompetent status, which may lead to suppression of microscopic tumor spread and improve the outcomes of patients with CRC and type 2 DM.
  • Toshihide Komatsubara, Yasunaru Sakuma, Naohiro Sata, Noriyoshi Fukushima
    Pathology international 70 (11) 857 - 864 2020/11 
    Extrahepatic bile duct (EHBD) cancer is a devastating cancer, and more common in Asian countries than in Western countries. Histological grading continues to be a highly relevant factor in prognosis and management of many kinds of cancer, however no uniform histological grading system exists for EHBD cancer. Histological heterogeneity within tumors is a problem in the evaluation of EHBD cancer. We developed an EHBD histological grading scheme to evaluate tumor differentiation pattern, and statistically analyzed its relationship with prognosis. In the present study, 257 surgically resected EHBD cancers were reviewed and their histological glandular differentiation (HGD) pattern was scored, and then we summed up the most and second most predominant scores. These scores were statistically analyzed for their relationship with patient prognosis. Patients showed a trend of shortening recurrence-free survival (RFS) and overall survival (OS) in association with higher HGD scores. In multivariate analyses, HGD score was determined to be an influential factor in RFS (P = 0.00041) and OS (P < 0.0001). In addition, combining HGD score and lymph node status correctly stratified patient prognosis in RFS. In conclusion, this new HGD scoring system is highly practical and has powerful prognostic value for EHBD cancer.
  • Hironori Yamamoto, Kouichi Miura, Koichi Hagiwara, Yuji Morisawa, Alan Kawarai Lefor, Naohiro Sata, Ryozo Nagai
    JMA journal 3 (4) 303 - 306 2020/10 
    The outbreak of the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) poses serious health and economic problems worldwide. One of the worst scenarios is the collapse of the medical care system due to nosocomial infections. SARS-CoV-2 quickly spreads in closed spaces, crowded areas, and close physical distances, which frequently occur in Japanese medical facilities. Although we are making efforts to avoid such situations, healthcare workers always face the risk of developing a SARS-CoV-2 infection in the workplace because of proximity. Thus, we need to battle SARS-CoV-2 using a unique strategy. We propose a novel strategy to eliminate SARS-CoV-2 infections: measurement of antibodies against SARS-CoV-2 and using the power of "immune survivors." We agree with using standard precautions and early isolation of patients with coronavirus disease 2019 (COVID-19) to block the spread of SARS-CoV-2 infection. However, we face difficulties carrying out these fundamental missions. Now, we focus on "immune survivors." If healthcare workers acquired the neutralizing antibody against SARS-CoV-2, they are considered "immune survivors" with a low risk of reinfection with SARS-CoV-2. These "immune survivors" can contribute to the care of patients with COVID-19 on the front line. Also, these "immune survivors" can function as an envelope by surrounding COVID-19 patients. As a result, "immune survivors" can eliminate the spread of SARS-CoV-2 in medical facilities as well as in society. We understand that the concept of "immune survivors" needs further discussion. No information is available on how long or the titer of neutralizing antibody required for protection from infection. We have just started to measure antibody levels against SARS-CoV-2 in healthcare workers in our hospital. This project will provide further information in the battle against the SARS-CoV-2 infection. (Clinical trial registration number: UMIN 000039997).
  • Yuta Hirata, Yukihiro Sanada, Takahiko Omameuda, Takumi Katano, Go Miyahara, Naoya Yamada, Noriki Okada, Yasuharu Onishi, Yasunaru Sakuma, Naohiro Sata
    Experimental and clinical transplantation : official journal of the Middle East Society for Organ Transplantation 18 (5) 612 - 617 2020/10 
    OBJECTIVES: Predicting the risk of posthepatectomy liver failure is important when performing extended hepatectomy. However, there is no established method to evaluate liver function and improve preoperative liver function in pediatric patients. MATERIALS AND METHODS: We show the clinical features of pediatric patients who underwent living donor liver transplant for posthepatectomy liver failure in hepatoblastoma. The subjects were 4 patients with hepatoblastoma who were classified as Pretreatment Extent of Disease III, 2 of whom had distal metastasis (chest wall and lung). RESULTS: Hepatic right trisegmentectomy was performed in 3 patients and extended left hepatectomy in 1 patient. The median alpha-fetoprotein level at the diagnosis of hepatoblastoma was 986300 ng/mL (range, 22500-2726350 ng/mL), and the median alpha-fetoprotein level before hepatectomy was 8489 ng/mL (range, 23-22500 ng/mL). The remnant liver volume after hepatectomy was 33.3% (range, 20% to 34.9%). Four patients had cholangitis after hepatectomy and progressed to posthepatectomy liver failure. The peak serum total bilirubin after hepatectomy was 11.4 mg/dL (range, 8.7-14.6 mg/dL). Living donor liver transplant was performed for these 4 patients with posthepatectomy liver failure, and they did not have a recurrence. CONCLUSIONS: When the predictive remnant liver volume by computed tomography-volumetry before extended hepatectomy for patients with hepatoblastoma is less than 40%, the possibility of posthepatectomy liver failure should be recognized.
  • Yuichi Aoki, Hideki Sasanuma, Yuki Kimura, Akira Saito, Kazue Morishima, Yuji Kaneda, Kazuhiro Endo, Atsushi Yoshida, Atsushi Kihara, Yasunaru Sakuma, Hisanaga Horie, Yoshinori Hosoya, Alan Kawarai Lefor, Naohiro Sata
    The Journal of international medical research 48 (10) 300060520962967 - 300060520962967 2020/10 
    Traumatic injury to the main pancreatic duct requires surgical treatment, but optimal management strategies have not been established. In patients with isolated pancreatic injury, the pancreatic parenchyma must be preserved to maintain long-term quality of life. We herein report a case of traumatic pancreatic injury with main pancreatic duct injury in the head of the pancreas. Two years later, the patient underwent a side-to-side anastomosis between the distal pancreatic duct and the jejunum. Eleven years later, he presented with abdominal pain and severe gastrointestinal bleeding from the Roux limb. Emergency surgery was performed with resection of the Roux limb along with central pancreatectomy. We attempted to preserve both portions of the remaining pancreas, including the injured pancreas head. We considered the pancreatic fluid outflow tract from the distal pancreatic head and performed primary reconstruction with a double pancreaticogastrostomy to avoid recurrent gastrointestinal bleeding. The double pancreaticogastrostomy allowed preservation of the injured pancreatic head considering the distal pancreatic fluid outflow from the pancreatic head and required no anastomoses to the small intestine.
  • Homare Ito, Hiroaki Kimura, Tadayoshi Karasawa, Shu Hisata, Ai Sadatomo, Yoshiyuki Inoue, Naoya Yamada, Emi Aizawa, Erika Hishida, Ryo Kamata, Takanori Komada, Sachiko Watanabe, Tadashi Kasahara, Takuji Suzuki, Hisanaga Horie, Joji Kitayama, Naohiro Sata, Kazuyo Yamaji-Kegan, Masafumi Takahashi
    Journal of immunology (Baltimore, Md. : 1950) 205 (5) 1393 - 1405 2020/09 [Refereed][Not invited]
     
    Intestinal ischemia/reperfusion (I/R) injury is a life-threatening complication that leads to inflammation and remote organ damage. The NLRP3 inflammasome regulates the caspase-1-dependent release of IL-1β, an early mediator of inflammation after I/R injury. In this study, we investigated the role of the NLRP3 inflammasome in mice with intestinal I/R injury. Deficiency of NLRP3, ASC, caspase-1/11, or IL-1β prolonged survival after intestinal I/R injury, but neither NLRP3 nor caspase-1/11 deficiency affected intestinal inflammation. Intestinal I/R injury caused acute lung injury (ALI) characterized by inflammation, reactive oxygen species generation, and vascular permeability, which was markedly improved by NLRP3 deficiency. Bone marrow chimeric experiments showed that NLRP3 in non-bone marrow-derived cells was the main contributor to development of intestinal I/R-induced ALI. The NLRP3 inflammasome in lung vascular endothelial cells is thought to be important to lung vascular permeability. Using mass spectrometry, we identified intestinal I/R-derived lipid mediators that enhanced NLRP3 inflammasome activation in lung vascular endothelial cells. Finally, we confirmed that serum levels of these lipid mediators were elevated in patients with intestinal ischemia. To our knowledge, these findings provide new insights into the mechanism underlying intestinal I/R-induced ALI and suggest that endothelial NLRP3 inflammasome-driven IL-1β is a novel potential target for treating and preventing this disorder.
  • Atsushi Kihara, Kazuya Takahashi, Ayataka Ishikawa, Yusuke Amano, Daisuke Matsubara, Hiroaki Kanda, Naohiro Sata, Noriyoshi Fukushima, Toshiro Niki
    Medical molecular morphology 53 (3) 177 - 182 2020/09 [Refereed][Not invited]
     
    We herein report a variant case of desmoplastic small round cell tumor (DSRCT) showing limited desmoplasia and confusing immunohistochemical findings. A 26-year-old male was referred for multiple abdominal masses. Laparoscopic biopsy showed only the solid proliferation of small round cells, and he was initially diagnosed with small cell carcinoma. At autopsy, the tumor spread diffusely throughout the abdominal and pelvic cavities. Although the tumor was composed of a predominantly solid pattern of small round cells, multiple samples revealed a fibrous stroma in limited areas only. While immunohistochemistry showed the diffuse expression of desmin, CD99, and bcl-2, epithelial differentiation was unclear with few cytokeratin-positive cells and no staining for the epithelial membrane antigen. Although fluorescence in situ hybridization analysis indicated the EWSR1 gene rearrangement, we were unable to exclude Ewing sarcoma considering the morphological and immunohistochemical findings. The diagnosis of DSRCT was confirmed with a reverse transcription-polymerase chain reaction for EWSR1-WT1 fusion transcripts. DSRCT must be included in a differential diagnosis of small round cell tumors even if desmoplasia is not immediately detected, and thorough sampling and a molecular analysis are mandatory.
  • Yoshiyuki Inoue, Hisanaga Horie, Yuko Homma, Ai Sadatomo, Makiko Tahara, Koji Koinuma, Hironori Yamaguchi, Toshiki Mimura, Atsushi Kihara, Alan Kawarai Lefor, Naohiro Sata
    Surgical case reports 6 (1) 174 - 174 2020/07 [Refereed][Not invited]
     
    BACKGROUND: Goblet cell carcinoid (GCC) is a neuroendocrine tumor usually found in the appendix. GCCs exhibit characteristic findings with mixed endocrine-exocrine features such as staining positive for neuroendocrine markers and producing mucin. The primary GCC of the rectum is exceedingly rare. CASE PRESENTATION: A 77-year-old Japanese male presented with hematochezia. Anal tenderness and a hard mass in the anal canal were found on the digital rectal examination, and colonoscopy was performed. Colonoscopy showed an irregularly shaped mass in the anal canal. Biopsy showed mixed features including adenocarcinoma in situ, well-differentiated adenocarcinoma, and mucinous carcinoma with invasive proliferation. No metastatic lesions were found on the computed tomography scan. Pelvic magnetic resonance imaging scan showed extramural growth of a tumor on the ventral side of the rectum without invasion to the prostate. Laparoscopic abdominoperineal resection was performed. The final diagnosis was well-differentiated adenocarcinoma in the mucosa and goblet cell carcinoid from the submucosa to the adventitia of the rectum. The patient was discharged from the hospital on postoperative day 16. Six months after resection, a computed tomography scan revealed multiple metastatic lesions in the liver. Several chemotherapy regimens were given, and the patient has stable disease 27 months after surgery. CONCLUSION: We present a patient with rectal GCC with metachronous liver metastases. Since GCC grows intramurally and is biologically aggressive compared to typical carcinoid lesions, the disease is usually diagnosed at an advanced stage. The development of optimal adjuvant chemotherapy is needed for those patients.
  • Yuta Hirata, Yukihiro Sanada, Takahiko Omameuda, Takumi Katano, Go Miyahara, Naoya Yamada, Noriki Okada, Yasuharu Onishi, Yasunaru Sakuma, Naohiro Sata
    Surgical case reports 6 (1) 159 - 159 2020/07 
    BACKGROUND: There have been no reports on the effectiveness of the administration of antithrombin III (AT III) for post-transplant portal vein thrombosis (PVT). We herein report a case of post-transplant PVT that was resolved by AT III treatment after living donor liver transplantation (LDLT). CASE PRESENTATION: The patient was a 57-year-old man who had been diagnosed with decompensate liver cirrhosis by hepatitis C virus infection. He presented with repeated hepatic coma and refractory ascites. Computed tomography (CT) revealed PVT of Yerdel classification grade II before LDLT. He underwent ABO-identical LDLT using a right lobe graft. A liver function test revealed elevated liver enzyme levels on post-operative day (POD) 14. The CT examination on POD 15 revealed PVT in the left side of the main portal vein at the side of left gastric vein ligation. AT III treatment from POD 15 to POD 24 was performed. Magnetic resonance imaging revealed that the PVT had decreased 10% on POD 27. Furthermore, AT III treatment from POD 28 to POD 32 was performed. The CT examination demonstrated the disappearance of PVT on POD 69 and thereafter, he had no recurrence of PVT on 10 post-operative month (POM). CONCLUSIONS: The present case suggests that the administration of AT III is safe and suitable for the treatment of post-transplant PVT.
  • Itsuki Naya, Yukihiro Sanada, Takumi Katano, Go Miyahara, Yuta Hirata, Naoya Yamada, Noriki Okada, Yasuharu Onishi, Yasunaru Sakuma, Naohiro Sata
    Annals of transplantation 25 e921193  2020/06 
    BACKGROUND The number of pregnancies after liver transplantation (LT) is increasing; however, the safety and incidence of complications associated with these pregnancies are still unclear. In this report, we retrospectively assessed the influences and problems associated with post-transplant pregnancy on allografts, recipients, and fetuses. MATERIAL AND METHODS A total of 14 pregnancies were identified in 8 female recipients between 2005 and 2018. The original disease was biliary atresia in all recipients. We provide a basic guide for the management of planned pregnancies in female recipients. RESULTS Of the 7 planned pregnancies, no recipients took mycophenolate mofetil (MMF) or had allograft liver dysfunction. Among the 7 unplanned conceptions, we judged that the pregnancy was inadequate to continue in 4 recipients due to taking MMF and 2 recipients due to allograft liver dysfunction at conception. However, 4 recipients who immediately stopped taking MMF continued with their pregnancies. Ten pregnancies resulted in live 11 births. Among obstetric complications or fetal and neonatal complications, gestational diabetes mellitus in 3 recipients was the most common. There were 3 miscarriages and 1 planned termination because of MMF medication and liver dysfunction. CONCLUSIONS Planned pregnancies in LT recipients can lead to the birth of a healthy baby and no influence on either the allograft or the recipient. However, unplanned pregnancies in LT recipients, such as recipients who take MMF or have allograft liver dysfunction, may have an adverse influence on the fetus.
  • Naoya Yamada, Tadayoshi Karasawa, Taiichi Wakiya, Ai Sadatomo, Homare Ito, Ryo Kamata, Sachiko Watanabe, Takanori Komada, Hiroaki Kimura, Yukihiro Sanada, Yasunaru Sakuma, Koichi Mizuta, Nobuhiko Ohno, Naohiro Sata, Masafumi Takahashi
    American journal of transplantation : official journal of the American Society of Transplantation and the American Society of Transplant Surgeons 20 (6) 1606 - 1618 1600-6135 2020/06 [Refereed][Not invited]
     
    Hepatic ischemia-reperfusion (I/R) injury is a major problem in liver transplantation (LT). Although hepatocyte cell death is the initial event in hepatic I/R injury, the underlying mechanism remains unclear. In the present study, we retrospectively analyzed the clinical data of 202 pediatric living donor LT and found that a high serum ferritin level, a marker of iron overload, of the donor is an independent risk factor for liver damage after LT. Since ferroptosis has been recently discovered as an iron-dependent cell death that is triggered by a loss of cellular redox homeostasis, we investigated the role of ferroptosis in a murine model of hepatic I/R injury, and found that liver damage, lipid peroxidation, and upregulation of the ferroptosis marker Ptgs2 were induced by I/R, and all of these manifestations were markedly prevented by the ferroptosis-specific inhibitor ferrostatin-1 (Fer-1) or α-tocopherol. Fer-1 also inhibited hepatic I/R-induced inflammatory responses. Furthermore, hepatic I/R injury was attenuated by iron chelation by deferoxamine and exacerbated by iron overload with a high iron diet. These findings demonstrate that iron overload is a novel risk factor for hepatic I/R injury in LT, and ferroptosis contributes to the pathogenesis of hepatic I/R injury.
  • Hidenori Tsukui, Hisanaga Horie, Koji Koinuma, Hideyuki Ohzawa, Yasunaru Sakuma, Yoshinori Hosoya, Hironori Yamaguchi, Kotaro Yoshimura, Alan Kawarai Lefor, Naohiro Sata, Joji Kitayama
    BMC cancer 20 (1) 411 - 411 2020/05 
    BACKGROUND: Anti-tumor effects of radiation therapy (RT) largely depend on host immune function. Adenosine with its strong immunosuppressive properties is an important immune checkpoint molecule. METHOD: We examined how intra-tumoral adenosine levels modify anti-tumor effects of RT in a murine model using an anti-CD73 antibody which blocks the rate-limiting enzyme to produce extracellular adenosine. We also evaluated CD73 expression in irradiated human rectal cancer tissue. RESULTS: LuM-1, a highly metastatic murine colon cancer, expresses CD73 with significantly enhanced expression after RT. Subcutaneous (sc) transfer of LuM-1 in Balb/c mice developed macroscopic sc tumors and microscopic pulmonary metastases within 2 weeks. Adenosine levels in the sc tumor were increased after RT. Selective RT (4Gyx3) suppressed the growth of the irradiated sc tumor, but did not affect the growth of lung metastases which were shielded from RT. Intraperitoneal administration of anti-CD73 antibody (200 μg × 6) alone did not produce antitumor effects. However, when combined with RT in the same protocol, anti-CD73 antibody further delayed the growth of sc tumors and suppressed the development of lung metastases presumably through abscopal effects. Splenocytes derived from RT+ CD73 antibody treated mice showed enhanced IFN-γ production and cytotoxicity against LuM-1 compared to controls. Immunohistochemical studies of irradiated human rectal cancer showed that high expression of CD73 in remnant tumor cells and/or stroma is significantly associated with worse outcome. CONCLUSION: These results suggest that adenosine plays an important role in the anti-tumor effects mediated by RT and that CD73/adenosine axis blockade may enhance the anti-tumor effect of RT, and improve the outcomes of patients with locally advanced rectal cancer.
  • Yuichi Aoki, Hisashi Oshiro, Akihiko Yoshida, Kazue Morishima, Atsushi Miki, Hideki Sasanuma, Yasunaru Sakuma, Alan Kawarai Lefor, Naohiro Sata
    BMC gastroenterology 20 (1) 105 - 105 2020/04 [Refereed][Not invited]
     
    BACKGROUND: Capicua transcriptional repressor (CIC) -rearranged sarcoma is characterized by small round cells, histologically similar to Ewing sarcoma. However, CIC-rearranged sarcoma has different clinical, histological, and immunohistochemical features from Ewing sarcoma. It is important to differentiate between these tumors. CASE PRESENTATION: The patient is a 44-year-old man with a duodenal tumor diagnosed in another hospital who presented with a history of melena. Laboratory studies showed anemia with a serum hemoglobin of 6.0 g/dL. He was hospitalized and gastrointestinal bleeding was controlled successfully with endoscopy. However, he suffered from appetite loss and vomiting and progression of anemia a few weeks after presentation. Upper gastrointestinal endoscopy showed a circumferential soft tumor in the second portion of the duodenum and the endoscope could not pass distally. Computed tomography scan showed a greater than 10 cm tumor in the duodenum, with compression of the inferior vena cava and infiltrating the ascending colon. A definitive pathologic diagnosis could not be established despite four biopsies from the tumor edge. Due to gastrointestinal obstruction and progression of anemia, a pylorus-preserving pancreaticoduodenectomy with partial resection of the inferior vena cava and right hemicolectomy was performed as a complete tumor resection. The tumor was diagnosed as a CIC-rearranged sarcoma, but 2 months postoperatively local recurrence and distant metastases to the liver and lung were found. The patient died 3 months after surgery. CONCLUSIONS: Although the only definitive treatment for CIC-rearranged sarcoma is surgical resection, the CIC-rearranged sarcoma is highly malignant with a poor prognosis even after radical resection. More research is needed to establish optimal treatment strategies.
  • Hideyuki Ohzawa, Akira Saito, Yuko Kumagai, Yuki Kimura, Hironori Yamaguchi, Yoshinori Hosoya, Alan Kawarai Lefor, Naohiro Sata, Joji Kitayama
    Oncology reports 43 (4) 1081 - 1088 2020/04 
    The peritoneal surface is the most frequent site of metastasis disease in patients with gastric cancer. Even after curative surgery and adjuvant chemotherapy, peritoneal recurrences often develop. Exosomes play pivotal roles in tumor metastasis via the transfer of microRNAs (miRNAs). In the present study, exosomes were isolated from peritoneal lavage fluid or ascites in 85 patients with gastric cancer and the relative expression levels of miR‑29s were examined. The expression of miR‑29a‑3p, miR‑29b‑3p and miR‑29c‑3p in peritoneal exosomes were all downregulated in patients with peritoneal metastases (PM) compared to those without PM. In 30 patients who underwent curative gastrectomy with serosa‑involved (T4) gastric cancer, 6 patients exhibited recurrence in the peritoneum within 12 months. The expression levels of miR‑29s at gastrectomy tended to be lower in these 6 patients than in the other 24 patients with significant differences in miR‑29b‑3p (P=0.003). When the patients were divided into two groups based on median levels of miR‑29s, peritoneal recurrence developed more frequently in patients with low expression of miR‑29b‑3p, and lower expression of miR‑29s were related with worse overall survival. miR‑29s are thought to play a suppressive role in the growth of disseminated peritoneal tumor cells. Reduced expression of miR‑29b in peritoneal exosomes is a strong risk factor of developing postoperative peritoneal recurrence.
  • Yoshiyuki Meguro, Hironori Yamaguchi, Joji Kitayama, Rihito Kanamaru, Shiro Matsumoto, Takashi Ui, Hidenori Haruta, Kentaro Kurashina, Shin Saito, Yoshinori Hosoya, Alan Kawarai Lefor, Naohiro Sata
    Surgical case reports 6 (1) 63 - 63 2020/03 
    BACKGROUND: Despite recent progress in systemic chemotherapy, the prognosis of patients with peritoneal metastases from gastric cancer is still poor. Efficacious intraperitoneal and systemic combination chemotherapy regimens to treat patients with peritoneal metastases have recently been developed. CASE PRESENTATION: A 74-year-old man with gastric cancer T4b (transverse mesocolon) N3 M1 (peritoneum) received combination chemotherapy with intraperitoneal administration of paclitaxel, intravenous oxaliplatin, and oral S-1. Eight courses of combined chemotherapy had remarkable anti-tumor effects on the primary lesion, lymph node metastases, and peritoneal metastases. Total gastrectomy with regional lymph node dissection was performed. Pathological examination revealed no viable tumor cells in the resected specimens. After gastrectomy, the patient received 25 courses of the same chemotherapy without oxaliplatin and has no evidence of recurrence 24 months later. DISCUSSION: Therapeutic approaches including systemic chemotherapy, extended resection, and heated intraperitoneal chemotherapy have been used to treat patients with peritoneal metastases. Repeat therapy with intraperitoneal paclitaxel has been used recently. Intraperitoneal administration of paclitaxel results in prolonged retention in the peritoneal cavity with effects against peritoneal metastases. Repeated administration of paclitaxel does not cause adhesions in the peritoneal cavity. When combination chemotherapy is effective, salvage gastrectomy is a promising option with minimal morbidity and mortality. CONCLUSION: Combined chemotherapy with intraperitoneal paclitaxel and systemic chemotherapy followed by gastrectomy is a promising strategy for patients with advanced gastric cancer and peritoneal metastases.
  • Naoya Yamada, Tadayoshi Karasawa, Hiroaki Kimura, Sachiko Watanabe, Takanori Komada, Ryo Kamata, Ariunaa Sampilvanjil, Junya Ito, Kiyotaka Nakagawa, Hiroshi Kuwata, Shuntaro Hara, Koichi Mizuta, Yasunaru Sakuma, Naohiro Sata, Masafumi Takahashi
    Cell death & disease 11 (2) 144 - 144 2020/02 [Refereed][Not invited]
     
    Acetaminophen (APAP) overdose is a common cause of drug-induced acute liver failure. Although hepatocyte cell death is considered to be the critical event in APAP-induced hepatotoxicity, the underlying mechanism remains unclear. Ferroptosis is a newly discovered type of cell death that is caused by a loss of cellular redox homeostasis. As glutathione (GSH) depletion triggers APAP-induced hepatotoxicity, we investigated the role of ferroptosis in a murine model of APAP-induced acute liver failure. APAP-induced hepatotoxicity (evaluated in terms of ALT, AST, and the histopathological score), lipid peroxidation (4-HNE and MDA), and upregulation of the ferroptosis maker PTGS2 mRNA were markedly prevented by the ferroptosis-specific inhibitor ferrostatin-1 (Fer-1). Fer-1 treatment also completely prevented mortality induced by high-dose APAP. Similarly, APAP-induced hepatotoxicity and lipid peroxidation were prevented by the iron chelator deferoxamine. Using mass spectrometry, we found that lipid peroxides derived from n-6 fatty acids, mainly arachidonic acid, were elevated by APAP, and that auto-oxidation is the predominant mechanism of APAP-derived lipid oxidation. APAP-induced hepatotoxicity was also prevented by genetic inhibition of acyl-CoA synthetase long-chain family member 4 or α-tocopherol supplementation. We found that ferroptosis is responsible for APAP-induced hepatocyte cell death. Our findings provide new insights into the mechanism of APAP-induced hepatotoxicity and suggest that ferroptosis is a potential therapeutic target for APAP-induced acute liver failure.
  • Yukiyasu Okamura, Satoru Yasukawa, Hiroto Narimatsu, Narikazu Boku, Akira Fukutomi, Masaru Konishi, Soichiro Morinaga, Hirochika Toyama, Yuji Kaneoka, Yasuhiro Shimizu, Shoji Nakamori, Naohiro Sata, Keisuke Yamakita, Amane Takahashi, Osamu Kainuma, Shoichi Hishinuma, Ryuzo Yamaguchi, Masato Nagino, Satoshi Hirano, Akio Yanagisawa, Keita Mori, Katsuhiko Uesaka
    Cancer science 111 (2) 548 - 560 2020/02 
    The high expression of human equilibrative nucleoside transporter-1 (hENT1) and the low expression of dihydropyrimidine dehydrogenase (DPD) are reported to predict a favorable prognosis in patients treated with gemcitabine (GEM) and 5-fluorouracil (5FU) as the adjuvant setting, respectively. The expression of hENT1 and DPD were analyzed in patients registered in the JASPAC 01 trial, which showed a better survival of S-1 over GEM as adjuvant chemotherapy after resection for pancreatic cancer, and their possible roles for predicting treatment outcomes and selecting a chemotherapeutic agent were investigated. Intensity of hENT1 and DPD expression was categorized into no, weak, moderate or strong by immunohistochemistry staining, and the patients were classified into high (strong/moderate) and low (no/weak) groups. Specimens were available for 326 of 377 (86.5%) patients. High expression of hENT1 and DPD was detected in 100 (30.7%) and 63 (19.3%) of 326 patients, respectively. In the S-1 arm, the median overall survival (OS) with low hENT1, 58.0 months, was significantly better than that with high hENT1, 30.9 months (hazard ratio 1.75, P = 0.007). In contrast, there were no significant differences in OS between DPD low and high groups in the S-1 arm and neither the expression levels of hENT1 nor DPD revealed a relationship with treatment outcomes in the GEM arm. The present study did not show that the DPD and hENT1 are useful biomarkers for choosing S-1 or GEM as adjuvant chemotherapy. However, hENT1 expression is a significant prognostic factor for survival in the S-1 arm.
  • Yuko Kumagai, Hideyuki Ohzawa, Hideyo Miyato, Hisanaga Horie, Yoshinori Hosoya, Alan Kawarai Lefor, Naohiro Sata, Joji Kitayama
    The Journal of surgical research 246 52 - 61 0022-4804 2020/02 [Refereed][Not invited]
     
    BACKGROUND: Low-density neutrophils (LDN) have been shown to be increased in peripheral blood in patients with various diseases and closely related to immune-mediated pathology. However, the frequency and function of LDN in circulating blood of the patients following abdominal surgery have not been well understood. METHODS: LDN were determined by CD66b(+) cells, which were copurified with mononuclear cells by density gradient preparations of peripheral blood of surgical patients. The effects of the purified LDN on T cell proliferation and tumor cell lysis were examined in vitro. Neutrophil extracellular traps (NETs) production was examined by extracellular nuclear staining. RESULTS: The number of LDN with an immature phenotype is markedly increased in peripheral blood samples in patients after abdominal surgery. The frequency of LDN correlated positively with operative time and intraoperative blood loss. The purified LDN significantly suppressed the proliferation of autologous T cells stimulated with anti-CD3 mAb coated on plate and partially inhibited the cytotoxicity of lymphocytes activated with recombinant interleukin-2 against a human gastric cancer cell, OCUM-1. The LDN also produced NETs after short-term culture in vitro, which efficiently trap many OCUM-1. These results suggest that surgical stress recruits immunosuppressive LDN in the circulation in the early postoperative period. CONCLUSIONS: The LDN may support the lodging of circulating tumor cells via NETs formation and inhibit T cell-mediated antitumor response in target organs, which may promote postoperative cancer metastases. Functional blockade of LDN might be an effective strategy to reduce tumor recurrence after abdominal surgery.
  • Katsusuke Mori, Koji Koinuma, Hiroshi Nishino, Hisanaga Horie, Alan Kawarai Lefor, Naohiro Sata
    International journal of surgery case reports 66 39 - 42 2020 
    INTRODUCTION: Metastases to the thyroid gland in patients with colorectal cancer are uncommon. We report a patient with rectal cancer who developed a metastasis to the thyroid gland. PRESENTATION OF CASE: The patient was a 45-year-old female five years status post rectal cancer resection. A thyroid lesion was detected on PET-CT scan with synchronous lung metastases. After pulmonary resection, a partial thyroidectomy was performed and pathological examination with immunohistochemical staining confirmed that the lesion was a metastasis from previous rectal cancer. She is free from recurrence two years after thyroid surgery. DISCUSSION: Colorectal metastases to the thyroid gland are usually seen with widespread disease, often with lung and liver metastases. The overall outcomes of previously reported patients with thyroid metastases were extremely poor, with most patients dying within months of diagnosis. Careful attention should be given to other sites of metastatic disease including the thyroid gland during postoperative follow-up. PET scan may be helpful to establish the diagnosis. CONCLUSION: Treatment decisions must be individualized, and depend on the presence of systemic disease. Selected patients may benefit from resection of metastases, and PET scan may be useful to identify patients who will benefit from resection.
  • Shinichiro Yokota, Masaru Koizumi, Kazutomo Togashi, Mitsuaki Morimoto, Yoshikazu Yasuda, Naohiro Sata, Alan Kawarai Lefor
    International journal of surgery (London, England) 73 65 - 71 2020/01 
    BACKGROUND: Data describing the association of preoperative pulmonary function testing (PFT) with postoperative pulmonary complications (PPC) are inconsistent. We conducted this prospective study to determine the ability of PFT to predict PPC. MATERIALS AND METHODS: Data were prospectively collected from 676 patients who underwent elective abdominal surgery (emergency and thoracic operations excluded). The primary outcome was the occurrence of PPC within 30 days. Patient and procedure-related factors were examined as risk factors. Multivariate logistic regression analysis was performed using risk factors identified with univariate analysis and area under the curve (AUC) analysis performed. RESULTS: PPC occurred in 29 patients (4.9%). History of smoking or abnormal physical examination were not significantly associated. Multivariate analysis identified age (p = 0.03), operative time (p = 0.02), blood transfusions (p = 0.002), and %VC (p = 0.001) as significant risk factors. AUC with a model including age, operative time, and blood transfusion was 0.83. The addition of %VC to these three variables increased the AUC to 0.89 (p = 0.1). CONCLUSIONS: Age, operative time, blood transfusion, and %VC are significantly associated with an increased risk of PPC. The addition of %VC to other risk factors did not significantly improve the ability to predict PPC, showing that preoperative PFT is not helpful to predict PPC.
  • Ken-Ichi Oshiro, Koji Koinuma, Misaki Matsumiya, Mariko Takami, Satoshi Inose, Katsumi Kurihara, Hisanaga Horie, Alan Kawarai Lefor, Naohiro Sata
    International journal of surgery case reports 66 136 - 138 2020 
    INTRODUCTION: Internal hernias are rare after laparoscopic colorectal resections. We report a patient with an internal hernia through a defect in the transverse mesocolon following laparoscopic resection. PRESENTATION OF CASE: A 52-year-old male underwent laparoscopic colectomy for transverse colon cancer and had an unremarkable postoperative course. Thirty days postoperatively, he presented to the emergency room with sudden onset abdominal pain and vomiting. Enhanced abdominal computed tomography scan showed strangulated small intestine in the left upper abdomen. An internal hernia through the mesenteric defect created during the recent colon resection was suspected, and emergency laparotomy was performed. One hundred thirty cm of small intestine was found herniated through a mesenteric defect. After repositioning the ischemic-appearing intestine, a 5 cm defect in the transverse mesocolon was found which had not been closed during the previous laparoscopic operation. No intestinal resection was needed, and the mesenteric defect closed with non-absorbable sutures. The post-operative course was unremarkable except for paralytic ileus, which resolved without further intervention. DISCUSSION: The incidence of internal hernia through a mesenteric defect after laparoscopic colorectal resection is quite low. Therefore, routine closure of the mesenteric defect after laparoscopic colorectal resection is not required. However, a left sided defect in the transverse mesocolon might be at higher risk of causing an internal hernia on anatomic grounds. CONCLUSION: We believe that mesenteric defects should be closed after laparoscopic resection of the left side of transverse colon, regardless of their size.
  • Hideyuki Ohzawa, Yuko Kumagai, Hironori Yamaguchi, Hideyo Miyato, Yasunaru Sakuma, Hisanaga Horie, Yoshinori Hosoya, Alan Kawarai Lefor, Naohiro Sata, Joji Kitayama
    Annals of gastroenterological surgery 4 (1) 84 - 93 2020/01 
    Aim: Peritoneal metastases (PM) frequently occur in patients with gastric cancer and result in a poor prognosis. Exosomes play pivotal roles in tumor metastasis through the transfer of microRNAs (miRNAs). We examined the exosomal miRNA profile in peritoneal fluids to identify novel biomarkers to reflect tumor burden in the peritoneum. Methods: Exosomes were isolated from peritoneal fluids of patients of gastric cancer with macroscopic (P1) or microscopic (P0CY1) peritoneal metastasis (PM) and comprehensive miRNA expression analysis was carried out. Expressions of candidate miRNAs were then validated in all 58 samples using TaqMan Advanced miRNA Assays. Results: In initial screening, we carried out comprehensive analysis of exosomal miRNA using peritoneal fluids from 11 and 14 patients with or without PM, respectively, and identified 11 dysregulated miRNAs in PM (+) samples. Validation analysis showed that four miRNAs (miR-21-5p, miR-92a-3p, miR-223-3p, and miR-342-3p) were significantly upregulated in 12 PM (+) samples, and their expression levels showed positive correlation with peritoneal cancer index. In contrast, miR-29 family were all downregulated in patients with PM (+) samples. Moreover, in 24 patients with pT4 tumor, miR-29 at gastrectomy tended to be lower in six patients with peritoneal recurrence with significant differences in miR-29b-3p (P = .012). Conclusion: Expression pattern of miRNAs in peritoneal exosomes well reflects the tumor burden in the peritoneal cavity and could be a useful biomarker in the treatment of PM.
  • Katsushi Suenaga, Shiro Matsumoto, Alan Kawarai Lefor, Yoshimasa Miura, Yoshinori Hosoya, Daigo Kuboki, Hidenori Haruta, Kentaro Kurashina, Atsushi Kihara, Daisuke Matsubara, Yasunari Sakuma, Joji Kitayama, Naohiro Sata
    International journal of surgery case reports 73 319 - 323 2020 [Refereed][Not invited]
     
    INTRODUCTION: Gastric adenocarcinomas with low grade atypia may be difficult to diagnose as gastric cancer by preoperative biopsy. We report an extremely well-differentiated adenocarcinoma (EWDA) of the stomach which appeared like a submucosal tumor diagnosed by preoperative endoscopic submucosal dissection. PRESENTATION OF CASE: A 70-year-old male was referred with a 3-month history of a submucosal-appearing lesion in the gastric wall found on endoscopy. Biopsies of the lesion were performed and were inconclusive for neoplasia. Endoscopic ultrasonography showed a low echoic tumor growing into the fourth layer of the gastric wall. It was difficult to identify the tumor by repeat biopsy. Endoscopic submucosal dissection of the lesion was performed and revealed adenocarcinoma, and laparoscopic total gastrectomy was performed. Histopathologic evaluation showed that the tumor was stage IIA (T3N0M0). There is no recurrence 12 months after resection. DISCUSSION: Gastric EWDAs are rare lesions, accounting for 0.6% of all gastric cancers. It is difficult to diagnose gastric EWDA especially if it appears like a submucosal tumor. This lesion was finally diagnosed by endoscopic submucosal dissection. CONCLUSION: Endoscopic submucosal dissection may facilitate establishing the preoperative diagnosis of a tumor thought to be a gastric EWDA based on its endoscopic appearance and pathological findings.
  • Yuki Kaneko, Shin Saito, Kazuya Takahashi, Rihito Kanamaru, Yoshinori Hosoya, Hironori Yamaguchi, Joji Kitayama, Toshiro Niki, Alan Kawarai Lefor, Naohiro Sata
    Clinical journal of gastroenterology 12 (6) 534 - 538 1865-7257 2019/12 [Refereed][Not invited]
     
    A 68-year-old male was referred with dysphagia. Endoscopic findings showed circular stenosis with a protruding mass in the lower esophagus. Biopsy showed adenocarcinoma and there was no evidence of distant metastases. A subtotal esophagectomy was performed. The resected specimen revealed a mixed neuroendocrine carcinoma with adenocarcinoma. The adenocarcinoma component was on the surface of the tumor and the neuroendocrine component invaded the deeper portion. Immunohistochemically, the neuroendocrine carcinoma component stained positive for cytokeratin 7 and cytokeratin 20, suggesting that the neuroendocrine carcinoma originated from the adenocarcinoma. The adenocarcinoma component stained positive for MUC2, which suggests that the adenocarcinoma component originated from Barrett's epithelium. Taken together, the neuroendocrine carcinoma may have originated from Barrett's epithelium. A metastasis to the liver was found 2 months after the surgical resection. Chemotherapy was administered, but there was no response. Most esophageal neuroendocrine carcinomas are accompanied by adenocarcinoma or squamous cell components, suggesting that these carcinomas originate from pluripotent cells in squamous or Barrett's epithelium. Appropriate chemotherapy for these lesions should be considered based on the cell of origin.
  • Takumi Katano, Yukihiro Sanada, Yuta Hirata, Naoya Yamada, Noriki Okada, Yasuharu Onishi, Koshi Matsumoto, Koichi Mizuta, Yasunaru Sakuma, Naohiro Sata
    Pediatric surgery international 35 (11) 1185 - 1195 2019/11 
    PURPOSE: Advances in interventional radiology (IVR) treatment have notably improved the prognosis of hepatic vein (HV) and portal vein (PV) complications following pediatric living donor liver transplantation (LDLT); however, graft failure may develop in refractory cases. Although endovascular stent placement is considered for recurrent stenosis, its indications are controversial. METHODS: We enrolled 282 patients who underwent pediatric LDLT in our department from May 2001 to September 2016. RESULTS: 22 (7.8%) HV complications occurred after LDLT. Recurrence was observed in 45.5% of the patients after the initial treatment, and 2 patients (9.1%) underwent endovascular stent placement. The stents were inserted at 8 months and 3.8 years following LDLT, respectively. After stent placement, both patients developed thrombotic obstruction and are currently being considered for re-transplantation. 40 (14.2%) PV complications occurred after LDLT. Recurrence occurred in 27.5% of the patients after the initial treatment, and 4 patients (10.0%) underwent endovascular stent treatment. The stents of all the patients remained patent, with an average patency duration of 41 months. CONCLUSION: Endovascular stent placement is an effective treatment for intractable PV complications following pediatric LDLT. However, endovascular stent placement for HV complications should be carefully performed because of the risk of intrastent thrombotic occlusion and the possibility of immunological venous injury.
  • Homare Ito, Ai Sadatomo, Yoshiyuki Inoue, Naoya Yamada, Emi Aizawa, Erika Hishida, Ryo Kamata, Tadayoshi Karasawa, Hiroaki Kimura, Sachiko Watanabe, Takanori Komada, Hisanaga Horie, Joji Kitayama, Naohiro Sata, Masafumi Takahashi
    Biochemical and biophysical research communications 519 (1) 15 - 22 2019/10 [Refereed][Not invited]
     
    BACKGROUND: Intestinal ischemia/reperfusion (I/R) injury is a life-threatening complication that leads to inflammation and remote organ damage. However, the underlying mechanism is not yet fully understood. Toll-like receptor 5 (TLR5) is highly expressed in mucosa and recognizes flagellin, the main component of the bacterial flagella. Here, we investigated the role of TLR5 in inflammation and tissue damage after intestinal I/R injury using TLR5-deficient mice. METHODS AND RESULTS: Intestinal levels of TLR5 mRNA and flagellin protein were elevated in wild-type mice subjected to intestinal I/R. Although TLR5 deficiency had no effect on intestinal flagellin levels, it significantly attenuated intestinal injury and inflammatory responses after intestinal I/R. TLR5 deficiency also markedly improved survival in mice after intestinal I/R injury. In wild-type mice, intestinal I/R injury induced remote organ damage, particularly in the lung, which was attenuated by TLR5 deficiency. Furthermore, TLR5 deficiency prevented lung inflammatory responses and vascular permeability after intestinal I/R injury. CONCLUSION: These findings demonstrate a novel role of TLR5 and provide new insights into the mechanism underlying inflammation and tissue damage after intestinal I/R injury.
  • Chieko Miyazaki, Mikio Shiozawa, Rintaro Koike, Kasumi Ogihara, Yumiko Sasaki, Satomi Shiba, Saki Nishida, Masako Sakuragi, Hirofumi Mizunuma, Takashi Fujita, Noriyoshi Fukushima, Alan K Lefor, Joji Kitayama, Naohiro Sata
    Journal of medical case reports 13 (1) 289 - 289 2019/09 [Refereed][Not invited]
     
    BACKGROUND: Primary sarcoma of the breast is rare. Surgery has been the only curative treatment available. Recently, neoadjuvant chemotherapy including anthracycline/ifosfamide has been reported effective for patients with high-risk sarcomas in a prospective trial. CASE PRESENTATION: A 52-year-old Japanese woman presented with a mass in her left breast. The 10 cm tumor was fixed to her chest wall on examination. A skin biopsy was performed which showed leiomyosarcoma. Neoadjuvant chemotherapy was given and the tumor became mobile. A mastectomy and axillary dissection were performed with surgically negative margins. After neoadjuvant chemotherapy, the amount of necrosis was profoundly influenced by chemotherapy, and the histological effect of neoadjuvant chemotherapy was assessed in reference to pre-neoadjuvant chemotherapy magnetic resonance imaging. CONCLUSION: In contrast to many other cancers, the evaluation of various treatments and of the histological effect of neoadjuvant chemotherapy for sarcoma has been difficult due to the rarity of these tumors. We report the case of a patient with a breast sarcoma, treated with neoadjuvant chemotherapy and discuss the appropriate pathological evaluation and therapeutic management.
  • Akira Saito, Hideyuki Ohzawa, Mineyuki Tojo, Yuko Kumagai, Rihito Kanamaru, Hidenori Tsukui, Satomi Shiba, Homare Ito, Naohiro Sata, Joji Kitayama
    CANCER RESEARCH 79 (13) 0008-5472 2019/07
  • Kumiko Mito, Michihiro Saito, Kohei Morita, Iruru Maetani, Naohiro Sata, Makiko Mieno, Noriyoshi Fukushima
    Pancreatology : official journal of the International Association of Pancreatology (IAP) ... [et al.] 19 (5) 793 - 793 1424-3903 2019/07 [Refereed][Not invited]
  • Shiro Matsumoto, Yoshinori Hosoya, Alan K Lefor, Yuji Ino, Hidenori Haruta, Kentaro Kurashina, Shin Saito, Joji Kitayama, Naohiro Sata
    Asian journal of endoscopic surgery 12 (3) 322 - 325 1758-5902 2019/07 [Refereed][Not invited]
     
    Gastrointestinal stromal tumors (GIST) in patients under 18 years of age are classified as pediatric GIST. Pediatric GIST are extremely rare, and there are no reports of laparoscopic-endoscopic cooperative surgery for these lesions. We report the use of non-exposed endoscopic wall-inversion surgery as a laparoscopic-endoscopic cooperative surgery-related procedure for the treatment of a pediatric GIST. The case involved a 17-year-old male patient who presented with anemia and was found to have a bleeding gastric tumor. The tumor was resected transorally using the non-exposed endoscopic wall-inversion surgery technique. No gene mutation of c-Kit or Platelet-Derived Growth Factor Receptor α (PDGFRα) was found, and the final pathological diagnosis was epithelial-type GIST due to a succinate dehydrogenase abnormality. Follow-up included a CT scan every 4 months. No recurrence has occurred to date.
  • Satomi Shiba, Atsushi Miki, Hideyuki Ohzawa, Takumi Teratani, Yasunaru Sakuma, Alan Kawarai Lefor, Joji Kitayama, Naohiro Sata
    The Journal of surgical research 238 79 - 89 0022-4804 2019/06 [Refereed][Not invited]
     
    OBJECTIVE: Mucin1 (MUC1), a member of the mucin family, is a glycoprotein which is often expressed in malignant cells. However, the expression and function of MUC1 in human duodenal adenocarcinoma (DAC) has not yet been characterized because of its low frequency. Here, we examined the functional roles of core protein (MUC1-C) in DAC. MATERIALS AND METHODS: Using a human duodenal cancer cell line, HuTu80, proliferation, migration, invasion, ALDH activity was assessed by cell counting kit-8, scratch wound healing, matrigel invasion, and ALDEFUOR assays, respectively. The function of MUC1 protein was evaluated with knockdown using specific siRNA as well as anti-MUC1-C peptide, GO203. MUC1 expression in human DAC was evaluated immunohistochemically in surgically resected tumors. RESULTS: The positive expression of MUC1 in HuTu80 was confirmed by RT-PCR and flow cytometry. In vitro cell growth was inhibited by the addition of 50-100 μM GO203 as well as treatment with siRNA for MUC1-C. Silencing of MUC1-C also significantly reduced migration, invasion, ALDH activity. Local injection of GO-203 (14 mg/kg) significantly suppressed the growth of subcutaneous HuTu80 tumors in nude mice. Immunohistochemically, MUC1 was strongly detected in seven DAC cases, but not in 11 others. The outcome of patients with high MUC1 expression was significantly worse than those without MUC1 expression. CONCLUSIONS: These results suggest that MUC1 is functionally associated with the malignant potential of DAC and could be a novel therapeutic target for this rare tumor.
  • Takashi Ui, Yoshitsugu Obi, Akihiro Shimomura, Alan K Lefor, Reza Fazl Alizadeh, Hyder Said, Ninh T Nguyen, Michael J Stamos, Kamyar Kalantar-Zadeh, Naohiro Sata, Hirohito Ichii
    Nephrology, dialysis, transplantation : official publication of the European Dialysis and Transplant Association - European Renal Association 34 (5) 810 - 818 2019/05 
    BACKGROUND: Abnormally high estimated glomerular filtration rates (eGFRs) are associated with endothelial dysfunction and frailty. Previous studies have shown that low eGFR is associated with increased morbidity, but few reports address high eGFR. The purpose of this study is to evaluate the association of high eGFR with surgical outcomes in patients undergoing surgery for gastrointestinal malignancies. METHODS: We identified patients who underwent elective surgery for gastrointestinal malignancies from 2005 to 2015 in the American College of Surgeons National Surgical Quality Improvement Program database. We evaluated associations of eGFR with surgical outcomes by Cox or logistic models with restricted cubic spline functions, adjusting for case mix variables (i.e. age, gender, race and diabetes). RESULTS: The median eGFR is 83 (interquartile range 67-96) mL/min/1.73 m2. Thirty-day mortality was 1.9% (2555/136 896). There is a U-shaped relationship between eGFR and 30-day mortality. The adjusted hazard ratios (95% confidence intervals) for eGFRs of 30, 60, 105 and 120 mL/min/1.73 m2 (versus 90 mL/min/1.73 m2) are 1.73 (1.52-1.97), 1.00 (0.89-1.11), 1.42 (1.31-1.55) and 2.20 (1.79-2.70), respectively. Similar associations are shown for other surgical outcomes, including return to the operating room and postoperative pneumonia. Subgroup analyses show that eGFRs both higher and lower than the respective medians are consistently associated with a higher risk of adverse outcomes across age, gender and race. CONCLUSIONS: High and low eGFRs are associated with more adverse surgical outcomes in patients undergoing surgery for gastrointestinal malignancies. The eGFR associated with the lowest postoperative risk is approximately at the median eGFR of a given population.
  • Koji Koinuma, Hisanaga Horie, Homare Ito, Daishi Naoi, Ai Sadatomo, Makiko Tahara, Yoshiyuki Inoue, Yoshihiko Kono, Takahiro Sasaki, Hideharu Sugimoto, Alan Kawarai Lefor, Naohiro Sata
    Asian journal of endoscopic surgery 12 (2) 150 - 156 1758-5902 2019/04 [Refereed][Not invited]
     
    INTRODUCTION: Transverse colon resection is one of the most difficult laparoscopic procedures because of anatomic hazards such as variations in the mesenteric vascular anatomy and the complex structure of organs and surrounding membranes. METHODS: We evaluated the short-term surgical outcomes of laparoscopic transverse colon resection using a creative approach. This approach included preoperative surgical simulation using virtual surgical anatomy by CT, a four-directional approach to the mesentery, and 3-D imaging during laparoscopic surgery. RESULTS: A total of 45 consecutive patients who underwent laparoscopic resection for transverse colon cancer from June 2013 to December 2017 were enrolled in this study. All procedures were completed safely, with minor postoperative complications, including two patients with anastomotic stenosis, two with intra-abdominal phlegmon, one with delayed gastric emptying, and one with pneumonia, all treated non-operatively. There were no conversions to open resection. Operation time was 203 min (range, 125-322 min), and the estimated blood loss during surgery was 5 mL (range, 0-370 mL). The mean postoperative hospital stay was 10 days (range, 7-21 days), and no patients required readmission. CONCLUSION: Short-term surgical outcomes after laparoscopic transverse colon resection demonstrated that this creative approach was safe and feasible. The four-directional approach to the meso-transverse attachment combined with preoperative radiological simulation can facilitate laparoscopic transverse colon surgery.
  • Toshihide Komatsubara, Hisashi Oshiro, Yasunaru Sakuma, Naohiro Sata, Toshiro Niki, Noriyoshi Fukushima
    Pathology international 69 (2) 86 - 93 1320-5463 2019/02 [Refereed][Not invited]
     
    Bile duct cancer is known to contain numerous fibroblasts, and reported to recruit cancer- associated fibroblasts by secreting platelet-derived growth factor-D (PDGF-D) which needs serine proteases, such as matriptase, to behave as a ligand. However, their expression pattern, and prognostic value have not been clarified. In this study, we investigated the clinicopathological significance of PDGF-D and matriptase expression in patients with extrahepatic bile duct cancer. The samples were obtained from 256 patients who underwent the surgical resection between 1991 and 2015, and the expression levels of PDGF-D and matriptase were evaluated immunohistochemically. Staining intensities and distribution were scored, and finally classified into low and high expression groups in cancer cells and stroma respectively. High expression of matriptase in the cancer stroma was detected in 91 tumors (40%). The high stromal matriptase expression was significantly associated with shorter recurrence-free survival (RFS) and overall survival (OS) (P = 0.0027 and 0.0023, respectively). Multivariate analyses also demonstrated that the stromal matriptase expression level was an independent influential factor in RFS (P = 0.0050) and OS (P = 0.0093). Our findings suggest that the high stromal matriptase expression was strongly associated with tumor progression, recurrence and poor outcomes in patients with extrahepatic bile duct cancer.
  • Yuki Kaneko, Shin Saito, Daijiro Takahashi, Takashi Ui, Hidenori Haruta, Kentaro Kurashina, Hironori Yamaguchi, Yoshinori Hosoya, Joji Kitayama, Alan Kawarai Lefor, Naohiro Sata
    International journal of surgery case reports 62 140 - 143 2019 [Refereed][Not invited]
     
    INTRODUCTION: Immune thrombocytopenic purpura is an acquired thrombocytopenia. Preoperative management of thrombocytopenia is important in patients with gastric cancer. Partial splenic embolization can be effective for patients with thrombocytopenia, but could lead to ischemic necrosis of the remnant stomach when performing subtotal gastrectomy with splenectomy. PRESENTATION OF CASE: The patient is an 84-year old woman evaluated for anemia. Endoscopy revealed an advanced gastric cancer with bleeding. The patient also had immune thrombocytopenic purpura with a platelet count <50,000/μL. Administration of platelets did not increase the platelet count. Partial splenic embolization was performed followed by administration of high-dose immunoglobulin. The platelet count was over 50,000/μL preoperatively. The patient underwent combined subtotal gastrectomy and splenectomy, followed by an uneventful course. DISCUSSION: Patients with immune thrombocytopenic purpura and advanced gastric cancer can have anemia. Partial splenic embolization has been used to treat patients with refractory immune thrombocytopenic purpura as an alternative to splenectomy. Preoperative partial splenic embolization and high-dose immunoglobulin therapy resulted an increased platelet count in this patient. Elderly patients with gastric cancer have a high risk of postoperative complications. Patients with gastric cancer undergoing total gastrectomy have an impaired postoperative quality of life compared to those who undergo subtotal gastrectomy. We performed a subtotal gastrectomy and splenectomy as a function-preserving operation, completed safely by maintaining blood flow to the remnant stomach. CONCLUSION: Partial splenic embolization is effective for patients with immune thrombocytopenic purpura and gastric cancer. Combined subtotal gastrectomy and splenectomy is achieved by preserving blood flow to the remnant stomach.
  • Kazuya Takahashi, Shin Saito, Yuki Kaneko, Shiro Matsumoto, Hironori Yamaguchi, Joji Kitayama, Yoshinori Hosoya, Hirotoshi Kawata, Alan Kawarai Lefor, Naohiro Sata
    International journal of surgery case reports 64 180 - 183 2019 [Refereed][Not invited]
     
    INTRODUCTION: Gastric hyperplastic polyps are common stomach lesion and these polyps are generally benign. However, they can undergo malignant transformation. Most reported cases of malignant transformation of gastric hyperplastic polyps have been to well or moderately differentiated adenocarcinoma, and those transformed into poorly differentiated adenocarcinoma are extremely rare. No case has been reported that has changed to diffuse type adenocarcinoma with lymphatic invasion. PRESENTATION OF CASE: A 48-year-old woman presented with worsening anemia. A polyp was seen in the gastric cardia seven years prior to presentation. Helicobacter pylori infection was also found at that time. She underwent upper gastrointestinal endoscopy and biopsy of the polyp revealed signet ring cell carcinoma. Total gastrectomy was performed due to concern about possible invasion into the submucosal layer and there was no evidence of distant metastases. Histologic examination revealed both poorly differentiated adenocarcinoma and signet ring cell carcinoma surrounded by hyperplastic epithelium at the head of the polyp. Lymphatic invasion was also found, and malignant cells were limited to the mucosa. DISCUSSION: Gastric hyperplastic polyps are commonly associated with chronic gastritis which is related to Helicobacter pylori infections. Gastric hyperplastic polyps are generally benign and rarely undergo malignant transformation to adenocarcinoma with differentiated histology. The gastric hyperplastic polyp in this patient transformed to poorly differentiated adenocarcinoma with lymphatic invasion. CONCLUSION: Even small polyps may become poorly differentiated adenocarcinoma with invasion, so close follow-up or endoscopic resection are recommended as well as eradication of Helico Pylori infection when appropriate.
  • Yuichi Aoki, Atsushi Miki, Tomoyuki Nakano, Hideki Sasanuma, Yasunaru Sakuma, Hisanaga Horie, Yoshinori Hosoya, Noriyoshi Fukushima, Alan Kawarai Lefor, Naohiro Sata
    BMC cancer 18 (1) 1249 - 1249 2018/12 [Refereed][Not invited]
     
    BACKGROUND: Thymomas are typically slow-growing tumors and AB type thymomas are considered no/low risk tumors with a better prognosis. Extra-thoracic metastases are extremely rare. To the best of our knowledge, no patient with an isolated splenic metastasis from a thymoma has been reported. We report a patient who underwent laparoscopic splenectomy for a slow-growing, isolated splenic metastasis, eight years after thymectomy. CASE PRESENTATION: The patient is a 78-year-old man. Eight years previously, the patient underwent extended thymectomy and postoperative radiation therapy for a thymoma. Five years after thymectomy, a nodule appeared in the spleen, and the lesion enlarged gradually for three years thereafter. The patient was referred for further examination and treatment. Computed tomography scan showed a sharply circumscribed 50 mm tumor slightly hypodense and heterogeneous lesion in the spleen. On T2-weighted images on Magnetic Resonance Imaging, the tumor had high intensity, equivalent to or slightly lower than that on T1-weighted images, and no decrease on diffusion-weighted images. The tumor was multinodular and showed a low-signal spoke-wheel sign in the margin, enhanced gradually in the dynamic study. Positron emission tomography-CT scan, showed relatively low accumulation. Surgical resection was undertaken, and pathological examination showed metastatic thymoma. The patient is without recurrence and has no other symptoms three years after splenectomy. CONCLUSIONS: This is the first report of an isolated splenic metastasis from a thymoma. Further cases are needed to standardize this surgery for such lesions.
  • Kohei Morita, Hisashi Oshiro, Kumiko Mito, Makiko Naka Mieno, Mio Tamba-Sakaguchi, Toshiro Niki, Atsushi Miki, Masaru Koizumi, Yasunaru Sakuma, Toshihide Komatsubara, Naohiro Sata, Noriyoshi Fukushima
    Medicine 97 (49) e13466  0025-7974 2018/12 [Refereed][Not invited]
     
    Little is known concerning the prognostic significance of the degree of lymphatic vessel invasion in pancreatic head cancer. To address this gap in knowledge, we retrospectively examined 60 patients with locally advanced, surgically resectable pancreatic head cancer who underwent pancreaticoduodenectomy and lymph node (LN) dissection.All cases were histopathologically diagnosed as ductal adenocarcinoma, stage II (25 pT3N0 cases, 35 pT3N1 cases). The following variables were investigated: age; sex; neoadjuvant therapy; adjuvant therapy; tumor size; tumor grade; invasion into the serosa, retropancreatic tissue, duodenum, bile duct, portal venous system and perineural area; cut margins; LN metastasis; and the number of invaded lymphatic vessels (LVI-score).Univariate analysis demonstrated that LN metastasis and an LVI-score ≥5 were significantly associated with poor disease-free survival. Multivariate Cox regression analysis confirmed that LN metastasis and an LVI-score ≥7 were significantly associated with poor disease-free survival. Additionally, LVI-scores ≥9 and ≥10 were comparable to or surpassed the significance of LN metastasis based on the hazard ratio. Univariate analysis demonstrated that tumor size >30 mm, duodenal invasion, LN metastasis and an LVI-score ≥2 were significantly associated with poor overall survival. Multivariate Cox regression analysis confirmed that LN metastasis and LVI-scores ≥9 and ≥10 were significantly associated with poor overall survival, and an LVI-score ≥10 was comparable to or surpassed the significance of LN metastasis based on the hazard ratio.Our study strongly suggests that a high degree of lymphatic vessel invasion is associated with a poor prognosis in patients with locally advanced, surgically resectable pancreatic head cancer.
  • Keiji Sano, Masakazu Yamamoto, Tetsushige Mimura, Itaru Endo, Shoji Nakamori, Masaru Konishi, Masaru Miyazaki, Toshifumi Wakai, Masato Nagino, Keiichi Kubota, Michiaki Unno, Naohiro Sata, Junji Yamamoto, Hiroki Yamaue, Tadahiro Takada
    Journal of hepato-biliary-pancreatic sciences 25 (11) 465 - 475 2018/11 
    BACKGROUND: Whether non-colorectal non-neuroendocrine liver metastasis (NCNNLM) should be treated surgically remains unclear. METHODS: Data regarding 1,639 hepatectomies performed between 2001 and 2010 for 1,539 patients with NCNNLM were collected from 124 institutions. Patient characteristics, types of primary tumor, characteristics of liver metastases, and post-hepatectomy outcomes were analyzed. RESULTS: The five most frequent primary tumors were gastric carcinoma (540 patients [35%]), gastrointestinal stromal tumor (204 patients [13%]), biliary carcinoma (150 patients [10%]), ovarian cancer (107 patients [7%]), and pancreatic carcinoma (77 patients [5%]). R0/1 hepatectomy was achieved in 90% of patients, with 1.5% in-hospital mortality rate. Overall and disease-free survival rates of 1,465 patients included in survival analysis were 41% and 21%, respectively, at 5 years, and 28% and 15%, respectively, at 10 years. Five-year survival associated with the five frequent primary tumors were 32%, 72%, 17%, 52%, and 31%, respectively, and factors predictive of a poor outcome differed by the primary tumor type. CONCLUSIONS: Our data indicated that hepatectomy is safe for NCNNLM and that patient prognoses vary depending on the type of primary tumors. Indications for hepatectomy should be determined with reference to survival rates and risk factors specific to each of the various types of primary tumor.
  • Hisanaga Horie, Koji Koinuma, Homare Ito, Ai Sadatomo, Daishi Naoi, Yoshihiko Kono, Yoshiyuki Inoue, Mitsuaki Morimoto, Makiko Tahara, Alan K Lefor, Naohiro Sata, Takahiro Sasaki, Hideharu Sugimoto
    Asian journal of endoscopic surgery 11 (4) 355 - 361 1758-5902 2018/11 [Refereed][Not invited]
     
    INTRODUCTION: Laparoscopic lateral pelvic lymph node dissection (LPLD) is technically challenging because of the complicated anatomy of the pelvic wall. To overcome this difficulty, we introduced preoperative 3-D simulation. The aim of the study is to investigate the usefulness of preoperative 3-D simulation for the safe conduct of laparoscopic LPLD for rectal cancer. METHODS: After undergoing colonoscopy, patients were brought to the radiology suite where multi-detector row CT was performed. Three-dimensional images were constructed at a workstation and showed branches of the iliac artery and vein, ureter, urinary bladder, and enlarged lymph nodes. All members of the surgical team participated in preoperative simulation using the 3-D images. RESULTS: A total of 10 patients with advanced lower rectal cancer and enlarged lateral pelvic lymph nodes underwent laparoscopic unilateral LPLD after total mesorectal excision, tumor-specific mesorectal excision, or total proctocolectomy. Four of the 10 patients (40%) had variations in pelvic vascular anatomy. The median operative time for unilateral LPLD was 91 min (range, 66-142 min) and gradually declined, suggesting a good learning curve. The median number of lateral pelvic lymph nodes harvested was nine (range, 3-16). The median estimated blood loss was 13 mL (range, 10-160 mL). No conversion to open surgery or intraoperative complications occurred. No patient had major postoperative complications. CONCLUSION: Preoperative 3-D simulation may be useful for the safe conduct of laparoscopic LPLD, especially for surgeons with limited prior experience.
  • Rihito Kanamaru, Hideyuki Ohzawa, Hideyo Miyato, Hironori Yamaguchi, Yoshinori Hosoya, Alan Kawarai Lefor, Naohiro Sata, Joji Kitayama
    Journal of visualized experiments : JoVE (138) 2018/08 
    Activated neutrophils release neutrophil extracellular traps (NETs), which can capture and destroy microbes. Recent studies suggest that NETs are involved in various disease processes, such as autoimmune disease, thrombosis, and tumor metastases. Here, we show a detailed in vitro technique to detect NET activity during the trapping of free tumor cells, which grow after attachment to NETs. First, we collected low density neutrophils (LDN) from postoperative peritoneal lavage fluid from patients who underwent laparotomies. Short-term culturing of LDN resulted in massive NET formation that was visualized with green fluorescent nuclear and chromosome counterstain. After co-incubation of human gastric cancer cell lines MKN45, OCUM-1, and NUGC-4 with the NETs, many tumor cells were trapped by the NETs. Subsequently, the attachment was completely abrogated by the degradation of NETs with DNase I. Time-lapse video revealed that tumor cells trapped by the NETs did not die but instead grew vigorously in a continuous culture. These methods may be applied to the detection of adhesive interactions between NETs and various types of cells and materials.
  • Yukihiro Sanada, Yasunaru Sakuma, Naohiro Sata
    BMC surgery 18 (1) 50 - 50 2018/08 
    BACKGROUND: The genesis of the "complex type" classification of pancreaticobiliary maljunction (PBM) is unclear, and the pancreaticobiliary anatomy is also varied according to each case. We encountered a patient with PBM and incomplete pancreatic divisum (PD). We herein discussed about the embryological etiology of pancreaticobiliary system predicted from PBM with incomplete PD. CASE PRESENTATION: A 67-year-old man was found to have a dilatation of the common bile duct (CBD) during a medical examination at 62 years of age. The dilatation of the CBD subsequently progressed, and he was admitted to our hospital for surgical treatment. Magnetic resonance cholangiopancreatography revealed a dilatation from the common hepatic duct to the middle bile duct with PBM. Endoscopic retrograde cholangiopancreatography from the papilla of Vater revealed the pancreatic main duct via the pancreatic branch duct, and PBM with dilatation of the CBD and incomplete PD were revealed. We performed an extrahepatic bile duct resection and hepaticojejunostomy because of high risk of malignant transformation. Taping and transection of the bile duct without dilatation on the pancreatic side were performed, and thereafter, two orifices of the common channel and ventral pancreatic duct were ligated. The level of amylase in the bile was 7217 IU/L, and a histological examination of the CBD showed an inflammatory change of CBD, not a malignant transformation. CONCLUSION: It is somewhat easy to identify the pancreatobiliary anatomy when the cause of embryology of both PBM and PD is thought to be an abnormal embryology of the ventral pancreas.
  • Kazuma Iwasaki, Mitsuaki Morimoto, Gaku Ota, Koji Koinuma, Hisanaga Horie, Naohiro Sata, Takeo Nakaya
    Medicine 97 (30) e11357  2018/07 
    RATIONALE: Although systemic lupus erythematosus (SLE) can be complicated by various gastrointestinal tract diseases, it is rarely associated with lupus enteritis and protein-losing enteropathy (PLE). We report here the successful surgical treatment of lupus enteritis and therapy-resistant and refractory PLE in a patient with SLE. We also provide a review of relevant literature. PATIENT CONCERNS: A 16-year-old girl presenting with polyarthritis, malar rash, and palmar erythema was indicated for steroid therapy on the basis of positive results for antinuclear, anti-Smith, and antiphospholipid antibodies, which confirmed the diagnosis of SLE. During the course of steroid therapy, the patient developed acute abdomen and hypoalbuminemia. DIAGNOSES: Computed tomography and Tc-labeled human serum albumin scintigraphy revealed abnormal findings, and a diagnosis of lupus enteritis and PLE was made. Steroid treatment was continued but no significant improvement was observed, and the patient was referred and admitted to our hospital. Double-balloon enteroscopy revealed multiple ischemic stenoses and mucosal necroses in the small intestine, suggesting that PLE was associated with ischemic enteritis due to antiphospholipid syndrome. The patient received steroids, immunosuppressive drugs, and antithrombotic therapy, with no improvement in symptoms. Thus, the disease was judged to be refractory and resistant to medical therapy, and the patient was indicated for surgical treatment. INTERVENTIONS: Partial small intestinal resection was performed by removing the segment of the small intestine presenting PLE lesions, and a double-end ileostomy was created. OUTCOMES: Multiple stenotic lesions were confirmed in the resected segment. Histopathology evaluation revealed marked inflammatory cell infiltration in the intestinal tract wall and recanalization of the vessels, suggesting a circulatory disorder caused by vasculitis and antiphospholipid syndrome. Postoperatively, the clinical course was good. Serum albumin levels and body weight increased as nutritional status improved significantly. Secondary enteroenterostomy with ileostomy closure could be performed at 2 months after the initial surgery. LESSONS: Timely surgical treatment can be successful in managing therapy-resistant and refractory PLE in patients with SLE.
  • Masato Ozaka, Hiroshi Ishii, Tosiya Sato, Makoto Ueno, Masafumi Ikeda, Kazuhiro Uesugi, Naohiro Sata, Kouichirou Miyashita, Nobumasa Mizuno, Kunihiro Tsuji, Takuji Okusaka, Junji Furuse
    Cancer chemotherapy and pharmacology 81 (6) 1017 - 1023 2018/06 
    BACKGROUND: We evaluated the efficacy and safety of a modified FOLFIRINOX regimen for chemotherapy-naïve patients with metastatic pancreatic cancer. METHODS: Patients with untreated metastatic pancreatic cancer (MPC) received modified FOLFIRINOX (intravenous oxaliplatin 85 mg/m2, irinotecan 150 mg/m2, 5-FU infusion 2400 mg/m2 over 46 h, no bolus 5-FU). The primary endpoints were overall survival and the incidence of grade 3 or higher neutropenia. No patients received prophylactic pegfilgrastim. RESULTS: Sixty-nine pts. were enrolled from 39 institutions in Japan. The median overall survival was 11.2 months [95% confidence interval (CI) 9.0-]. The median progression-free survival was 5.5 months (95% CI 4.1-6.7). The response rate was 37.7% (95% CI 26.3-50.2), and the disease control rate was 78.3% (95% CI 66.7-87.3). The incidence of grade 3 or higher neutropenia was 47.8%. Serious adverse events occurred in six patients (8.7%). All AE proportions were less than those in the previous Japanese full-dose phase II study. One patient died due to interstitial pneumonia related to treatment. CONCLUSION: This is the first prospective study of modified FOLFIRINOX in Asia. Modified FOLFIRINOX in this study has an improved safety profile with maintained efficacy in MPC without prophylactic pegfilgrastim.
  • Kumiko Mito, Michihiro Saito, Kohei Morita, Iruru Maetani, Naohiro Sata, Makiko Mieno, Noriyoshi Fukushima
    Pancreatology : official journal of the International Association of Pancreatology (IAP) ... [et al.] 18 (4) 407 - 412 1424-3903 2018/06 [Refereed][Not invited]
     
    BACKGROUND: Intraductal papillary mucinous neoplasm (IPMN) of the pancreas is a primary pancreatic ductal epithelial neoplasm with the potential to develop into an invasive adenocarcinoma. This study aimed to investigate the clinicopathologic and prognostic significance of four potential biomarkers for the preoperative evaluation of patients with IPMN. MATERIALS AND METHODS: Clinicopathologic materials from 104 patients with IPMN who underwent surgical resection at Jichi Medical University Hospital were analyzed. IPMNs (110 lesions in total) were histologically classified into low-grade IPMN (Group 1; n = 68), high-grade IPMN (Group 2; n = 16), or IPMN with an associated invasive carcinoma (Group 3; n = 26). We evaluated the immunohistochemical expression of MUC13, AGR2, FUT8, and FXYD3, which were previously reported to be overexpressed in pancreatic ductal adenocarcinoma. RESULTS: The expression of MUC13 was more common in Group 3 compared with groups 1 and 2 (p < 0.001) and was associated with poor prognosis (p = 0.004). The expression of MUC13 was not associated with age, sex, tumor location, histological subtype, lymphatic or vascular invasion, or neural invasion. In most cases of IPMN, the loss of expression of AGR2 appeared to show an association with tumor recurrence and poorly differentiated histology of invasive carcinoma; however, this association was not statistically significant. The expressions of FUT8 and FXYD3were not associated with the clinicopathological features of IPMNs. CONCLUSIONS: The results suggest that MUC13 overexpression and loss of expression of AGR2 may predict the progression of IPMN and an unfavorable prognosis in patients with IPMN.
  • Homare Ito, Yoshiyuki Inoue, Ai Sadatomo, Naoya Yamada, Ryo Kamata, Sachiko Watanabe, Tadayoshi Karasawa, Hiroaki Kimura, Yasunaru Sakuma, Hisanaga Horie, Yoshinori Hosoya, Joji Kitayama, Naohiro Sata, Masafumi Takahashi
    GASTROENTEROLOGY 154 (6) S497 - S497 0016-5085 2018/05 
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  • Daishi Naoi, Hisanaga Horie, Koji Koinuma, Yoshiyuki Inoue, Homare Ito, Yosihiko Kono, Katsusuke Mori, Makiko Tahara, Ai Sadatomo, Yasunaru Sakuma, Yoshinori Hosoya, Joji Kitayama, Alan K. Lefor, Naohiro Sata
    GASTROENTEROLOGY 154 (6) S1351 - S1351 0016-5085 2018/05 
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  • Tsutomu Sugihara, Mitsuru Koizumi, Keiko Hayakawa, Yoshinori Ito, Naohiro Sata
    Clinical nuclear medicine 43 (5) 365 - 366 2018/05 
    Atypical femoral fractures (AFFs) occur in both osteoporosis patients and cancer patients who receive long-term bisphosphonate treatment. Denosumab offers an alternative approach for the treatment of bone metastases. We describe a 59-year-old woman with a history of breast carcinoma and bone metastasis who was prescribed denosumab for 4 years. The patient had no history of any prior bisphosphonate use. Bone scintigraphy showed an abnormal uptake in the right femur, which was confirmed as an impending AFF or atypical femoral stress reaction. In oncological patients receiving long-term denosumab, AFF should be included as a differential diagnosis for focal femoral findings.
  • Yoshiyuki Meguro, Kanako Miyano, Shigeto Hirayama, Yuki Yoshida, Naoto Ishibashi, Takumi Ogino, Yuriko Fujii, Sei Manabe, Moeko Eto, Miki Nonaka, Hideaki Fujii, Yoichi Ueta, Minoru Narita, Naohiro Sata, Toshihiko Yada, Yasuhito Uezono
    Journal of pharmacological sciences 137 (1) 67 - 75 2018/05 
    Oxytocin (OT) is a 9-amine neuropeptide that plays an essential role in mammalian labor, lactation, maternal bonding, and social affiliation. OT has been reported to exert an analgesic effect in both humans and animals, and the results of certain animal experiments have shown that the analgesic effect of OT is partially blocked by opioid receptor antagonists. To investigate the relationship between OT and μ opioid receptor (MOR), we evaluated how OT affects MOR in vitro by performing an electrical impedance-based receptor biosensor assay (CellKey™ assay), an intracellular cAMP assay, and a competitive receptor-binding analysis by using cells stably expressing human MOR and OT receptor. In both the CellKey™ assay and the intracellular cAMP assay, OT alone exerted no direct agonistic effect on human MOR, but treatment with 10-6 M OT markedly enhanced the MOR signaling induced by 10-6 M endomorphin-1, β-endorphin, morphine, fentanyl, and DAMGO. Moreover, in the competitive receptor-binding assay, 10-6 M OT did not alter the affinity of endomorphin-1 or morphine for MOR. These results suggest that OT could function as a positive allosteric modulator that regulates the efficacy of MOR signaling, and thus OT might represent a previously unrecognized candidate analgesic agent.
  • Yasuhiro Hagiwara, Yasuo Ohashi, Katsuhiko Uesaka, Narikazu Boku, Akira Fukutomi, Yukiyasu Okamura, Masaru Konishi, Ippei Matsumoto, Yuji Kaneoka, Yasuhiro Shimizu, Shoji Nakamori, Hirohiko Sakamoto, Soichiro Morinaga, Osamu Kainuma, Koji Imai, Naohiro Sata, Shoichi Hishinuma, Hitoshi Ojima, Ryuzo Yamaguchi, Satoshi Hirano, Takeshi Sudo
    European journal of cancer (Oxford, England : 1990) 93 79 - 88 2018/04 
    BACKGROUND: Adjuvant chemotherapy with S-1 for resected pancreatic cancer demonstrated survival benefits compared with gemcitabine in the JASPAC 01 trial. We investigated the effect of these agents on health-related quality of life (HRQOL) of patients in the JASPAC 01 trial. METHODS: Patients with resected pancreatic cancer were randomly assigned to receive gemcitabine (1000 mg/m2 weekly for three of four weeks for up to six cycles) or S-1 (40, 50, or 60 mg twice daily for four of six weeks for up to four cycles). HRQOL was assessed using the EuroQol-5D-3L (EQ-5D) questionnaire at baseline, months three and six, and every 6 months thereafter. HRQOL end-points included change in EQ-5D index from baseline, responses to five items in the EQ-5D, and quality-adjusted life months up to 24 months. RESULTS: Of randomised 385 patients, 354 patients were included in HRQOL analysis. Mean change in the EQ-5D index was similar in the S-1 and gemcitabine groups within 6 months from treatment initiation (difference, 0.024; P = 0.112), whereas corresponding mean from 12 to 24 months was better in the S-1 group than in the gemcitabine group (difference, 0.071; P < 0.001). Problems in mobility and pain/discomfort were also less frequent in the S-1 group than in the gemcitabine group in that period. Quality-adjusted life months were longer in the S-1 group than in the gemcitabine group (P < 0.001). CONCLUSION: Adjuvant chemotherapy with S-1 does not improve HRQOL within 6 months from treatment initiation but does improve HRQOL thereafter and quality-adjusted life months. CLINICAL TRIAL REGISTRATION NUMBER: UMIN000000655 at UMIN CTR.
  • Komatsubara Toshihide, Fukushima Noriyoshi, Oshiro Hisashi, Niki Toshiro, Sakuma Yasunaru, Sata Naohiro
    MODERN PATHOLOGY 31 681 - 682 0893-3952 2018/03 [Refereed][Not invited]
  • Joji Kitayama, Hironori Ishigami, Hironori Yamaguchi, Yasunaru Sakuma, Hisanaga Horie, Yoshinori Hosoya, Alan Kawarai Lefor, Naohiro Sata
    Annals of gastroenterological surgery 2 (2) 116 - 123 2018/03 [Refereed][Not invited]
     
    Despite recent advances in chemotherapy, outcomes of patients with peritoneal metastases (PM) from gastric cancer are still very poor and standard treatment has not been established. Although oral S-1 appears to be effective for patients with PM, the effects of systemic chemotherapy are limited. Cytoreductive surgery (CRS) and hyperthermic intraperitoneal chemotherapy (HIPEC) yield fewer benefits in patients with PM from gastric cancer than in patients with PM from other malignancies. In comparison, repeated intraperitoneal chemotherapy (RIPEC) with taxanes using an implantable peritoneal access port has a pharmacokinetic advantage for the control of peritoneal lesions and in combination with systemic chemotherapy can result in surprisingly long-term survival in patients with PM from gastric cancer. Herein, we review the results of recent clinical studies specifically targeting PM from gastric cancer and discuss future prospects for an intraperitoneal approach to the ideal treatment of patients with gastric cancer with peritoneal involvement.
  • Rihito Kanamaru, Hideyuki Ohzawa, Hideyo Miyato, Shiro Matsumoto, Hidenori Haruta, Kentaro Kurashina, Shin Saito, Yoshinori Hosoya, Hironori Yamaguchi, Hiroharu Yamashita, Yasuyuki Seto, Alan Kawarai Lefor, Naohiro Sata, Joji Kitayama
    Scientific reports 8 (1) 632 - 632 2018/01 [Refereed][Not invited]
     
    Many types of immune cells appear in peritoneal cavity after abdominal surgery. In patients who underwent laparotomy due to gastric cancer, peritoneal lavages were obtained before and after surgical procedure. Cells were recovered from intermediate layer after Ficoll-Hypaque centrifugation and analyzed for phenotypes and functions, especially focused on low density neutrophils (LDN). The number of CD66b (+) LDN with mature phenotype was markedly elevated in postoperative as compared with preoperative lavages. Short term culture of the purified LDN produced many threadlike structures positive for SYTOX, nucleic acid staining, as well as histone and myeloperoxidase, suggesting the NETs formation. Human gastric cancer cells, MKN45, OCUM-1 and NUGC-4, were selectively attached on the NETs, which was totally abolished by the pretreatment of DNAse I. Intraperitoneal (IP) co-transfer of the LDN with MKN45 in nude mice strongly augments the metastasis formation on peritoneum, which was strongly suppressed by the following IP administration of DNAse I. Many NETs-like structures were detected on the surface of human omental tissue resected by gastrectomy. NETs on peritoneal surface can assist the clustering and growth of free tumor cells disseminated in abdomen. Disruption of the NETs by DNAse might be useful to prevent the peritoneal recurrence after abdominal surgery.
  • Ippei Fukada, Kazuhiro Araki, Kokoro Kobayashi, Tomoko Shibayama, Shunji Takahashi, Naoya Gomi, Yumi Kokubu, Katsunori Oikado, Rie Horii, Futoshi Akiyama, Takuji Iwase, Shinji Ohno, Kiyohiko Hatake, Naohiro Sata, Yoshinori Ito
    Radiology 286 (1) 49 - 57 2018/01 
    Purpose To evaluate the association between tumor shrinkage patterns shown with magnetic resonance (MR) imaging during neoadjuvant chemotherapy (NAC) and prognosis in patients with low-grade luminal breast cancer. Materials and Methods This retrospective study was approved by the institutional review board and informed consent was obtained from all subjects. The low-grade luminal breast cancer was defined as hormone receptor-positive and human epidermal growth factor receptor 2-negative with nuclear grades 1 or 2. The patterns of tumor shrinkage as revealed at MR imaging were categorized into two types: concentric shrinkage (CS) and non-CS. Among 854 patients who had received NAC in a single institution from January 2000 to December 2009, 183 patients with low-grade luminal breast cancer were retrospectively evaluated for the development set. Another data set from 292 patients who had received NAC in the same institution between January 2010 and December 2012 was used for the validation set. Among these 292 patients, 121 patients with low-grade luminal breast cancer were retrospectively evaluated. Results In the development set, the median observation period was 67.9 months. Recurrence was observed in 31 patients, and 16 deaths were related to breast cancer. There were statistically significant differences in both the disease-free survival (DFS) and overall survival (OS) rates between patterns of tumor shrinkage (P < .001 and P < .001, respectively). Multivariate analysis demonstrated that the CS pattern had the only significant independent association with DFS (P = .001) and OS (P = .009) rate. In the validation set, the median follow-up period was 56.9 months. Recurrence was observed in 20 patients (16.5%) and eight (6.6%) deaths were related to breast cancer. DFS rate was significantly longer in patients with the CS pattern (72.8 months; 95% confidence interval [CI]: 69.9, 75.6 months) than in those with the non-CS pattern (56.0 months; 95% CI: 49.1, 62.9 months; P ≤ .001). The CS pattern was associated with an excellent prognosis (median OS, 80.6 months; 95% CI: 79.3, 81.8 months vs 65.0 months; 95% CI: 60.1, 69.8 months; P = .004). Multivariate analysis demonstrated that the CS pattern had the only significant independent association with DFS (P = .007) and OS (P = .037) rates. Conclusion The CS pattern as revealed at MR imaging during NAC had the only significant independent association with prognosis in patients with low-grade luminal breast cancer. © RSNA, 2017.
  • Fumihiko Miura, Kohji Okamoto, Tadahiro Takada, Steven M Strasberg, Horacio J Asbun, Henry A Pitt, Harumi Gomi, Joseph S Solomkin, David Schlossberg, Ho-Seong Han, Myung-Hwan Kim, Tsann-Long Hwang, Miin-Fu Chen, Wayne Shih-Wei Huang, Seiki Kiriyama, Takao Itoi, O James Garden, Kui-Hin Liau, Akihiko Horiguchi, Keng-Hao Liu, Cheng-Hsi Su, Dirk J Gouma, Giulio Belli, Christos Dervenis, Palepu Jagannath, Angus C W Chan, Wan Yee Lau, Itaru Endo, Kenji Suzuki, Yoo-Seok Yoon, Eduardo de Santibañes, Mariano Eduardo Giménez, Eduard Jonas, Harjit Singh, Goro Honda, Koji Asai, Yasuhisa Mori, Keita Wada, Ryota Higuchi, Manabu Watanabe, Toshiki Rikiyama, Naohiro Sata, Nobuyasu Kano, Akiko Umezawa, Shuntaro Mukai, Hiromi Tokumura, Jiro Hata, Kazuto Kozaka, Yukio Iwashita, Taizo Hibi, Masamichi Yokoe, Taizo Kimura, Seigo Kitano, Masafumi Inomata, Koichi Hirata, Yoshinobu Sumiyama, Kazuo Inui, Masakazu Yamamoto
    Journal of hepato-biliary-pancreatic sciences 25 (1) 31 - 40 2018/01 
    The initial management of patients with suspected acute biliary infection starts with the measurement of vital signs to assess whether or not the situation is urgent. If the case is judged to be urgent, initial medical treatment should be started immediately including respiratory/circulatory management if required, without waiting for a definitive diagnosis. The patient's medical history is then taken; an abdominal examination is performed; blood tests, urinalysis, and diagnostic imaging are carried out; and a diagnosis is made using the diagnostic criteria for cholangitis/cholecystitis. Once the diagnosis has been confirmed, initial medical treatment should be started immediately, severity should be assessed according to the severity grading criteria for acute cholangitis/cholecystitis, and the patient's general status should be evaluated. For mild acute cholangitis, in most cases initial treatment including antibiotics is sufficient, and most patients do not require biliary drainage. However, biliary drainage should be considered if a patient does not respond to initial treatment. For moderate acute cholangitis, early endoscopic or percutaneous transhepatic biliary drainage is indicated. If the underlying etiology requires treatment, this should be provided after the patient's general condition has improved; endoscopic sphincterotomy and subsequent choledocholithotomy may be performed together with biliary drainage. For severe acute cholangitis, appropriate respiratory/circulatory management is required. Biliary drainage should be performed as soon as possible after the patient's general condition has been improved by initial treatment and respiratory/circulatory management. Free full articles and mobile app of TG18 are available at: http://www.jshbps.jp/modules/en/index.php?content_id=47. Related clinical questions and references are also included.
  • Yurie Futo, Shin Saito, Hideyo Miyato, Ai Sadatomo, Yuki Kaneko, Yoshihiko Kono, Daisuke Matsubara, Hisanaga Horie, Alan Kawarai Lefor, Naohiro Sata
    International journal of surgery case reports 53 358 - 361 2018 [Refereed][Not invited]
     
    INTRODUCTION: Duodenal gastrointestinal tumors (GISTs) are rare. Duodenal GISTs and pancreatic neuroendocrine tumors (NETs) may appear similar on imaging studies. GISTs arising from the second or third portions of duodenum may be incorrectly diagnosed as pancreatic NETs. PRESENTATION OF CASE: The patient is a 79-year-old man who was referred to our hospital with a history of tarry stools and loss of consciousness. Urgent upper digestive tract endoscopy revealed a bleeding submucosal duodenal lesion, which was controlled using endoscopic clips. Enhanced computed tomography scan showed a hyper-vascular mass 50 mm in diameter, at the pancreatic uncus. The patient underwent a pylorus-preserving pancreaticoduodenectomy. Histologically, the tumor was composed of spindle-shaped cells immunohistochemically positive for c-kit and CD34, and the lesion diagnosed as a duodenal GIST. DISCUSSION: Duodenal GISTs often present with gastrointestinal bleeding, which can necessitate emergency surgery. Surgical resection with regional lymph node dissection is the optimal treatment for pancreatic NETs. In contrast, GISTs are generally treated with a minimal resection and without lymph node dissection. Thus, establishing the diagnosis is important in the management of these tumors. Endoscopic ultrasound-guided fine needle aspiration (EUS-FNA) is effective to establish the diagnosis of these lesions. CONCLUSION: A tumor located in the pancreatic head or mesenteric side of the duodenum cannot always be diagnosed based on imaging, and is ideally diagnosed histologically to guide the extent of resection. While EUS-FNA can establish the diagnosis, the complications of this procedure must be considered.
  • Takeo Nakaya, Hisashi Oshiro, Takumi Saito, Yasunaru Sakuma, Hisanaga Horie, Naohiro Sata, Akira Tanaka
    International journal of clinical and experimental pathology 11 (6) 3141 - 3146 1936-2625 2018 [Refereed][Not invited]
     
    We report a unique case of a 74-old man, who presented with double cancers, showing metastasis of pancreatic cancer to colon cancer. Histopathological examination after surgery revealed that the patient had ascending colon cancer, which metastasized to the liver (pT4N0M1), as well as pancreatic cancer (pT2N1M1) that metastasized to the most invasive portion of the colon cancer, namely the serosal to subserosal layers. Although the mechanisms for this scenario have yet to be elucidated, we speculate that the metastatic pancreatic carcinoma overtook the stromal microenvironment of the colon cancer. Namely, the cancer microenvironment enriched by cancer-associated fibroblasts, which supported the colon cancer, might be suitable for the invasion and engraftment by pancreatic carcinoma. The similarity of histological appearance might make it difficult to distinguish metastatic pancreatic carcinoma within colon cancer. Furthermore, the metastasis of pancreatic carcinoma in colon carcinoma might be more common, despite it not having been previously reported.
  • Shiro Matsumoto, Yoshinori Hosoya, Alan Kawarai Lefor, Hidenori Haruta, Takashi Ui, Kentaro Kurashina, Shin Saito, Kentaro Ashizawa, Takahiro Sasaki, Joji Kitayama, Naohiro Sata
    International journal of surgery case reports 44 118 - 121 2018 [Refereed][Not invited]
     
    INTRODUCTION: Black adrenal adenoma (BAA) is a rare, benign adrenal lesion with a black or brown appearance. This is the first report of this lesion in a patient with a synchronous esophageal cancer and highlights the importance of considering a false positive finding on a Positron Emission Tomography (PET) scan, which might otherwise preclude resection. PRESENTATION OF CASE: A 73-year-old male was diagnosed with mid-esophagus carcinoma. Computed tomography scan revealed an enlarged left adrenal gland. Plasma adrenocorticotropic hormones levels were normal. To characterize the adrenal lesion, a PET scan was obtained which showed high uptake of 18F-fluoro-2-deoxy-d-glucose (FDG), consistent with a metastasis, suggesting T3N2M1, clinical stage IV esophageal cancer. After two courses of neo-adjuvant therapy, sub-total esophagectomy and left adrenalectomy were performed. The adrenal tumor was soft, and black in color, diagnosed as a BAA on histology. The pathologic stage of the esophageal cancer was T3N0M0, Stage II. Six months after surgery, he is alive without recurrence. DISCUSSION: High FDG uptake by an adrenal lesion on PET scan, as in this patient, usually suggests a metastatic lesion. Although rare, patients with esophageal cancer and adrenal metastases have been reported to have long-term survival, so it is important to characterize an adrenal lesion when found. CONCLUSION: Most adrenal lesions with high FDG uptake are malignant, but BAA is also positive on PET scan. Although rare, BAA should be considered in patients with solitary adrenal lesions with high uptake on PET scan, even in the presence of a malignancy.
  • Shin Saito, Chao Yan, Hisashi Fukuda, Yoshinori Hosoya, Shiro Matsumoto, Daisuke Matsubara, Joji Kitayama, Alan Kawarai Lefor, Naohiro Sata
    International journal of surgery case reports 44 207 - 211 2018 [Refereed][Not invited]
     
    INTRODUCTION: Gastric leiomyomas are benign mesenchymal tumors, comprising about 2.5% of gastric neoplasms, which can be difficult to differentiate from gastrointestinal stromal tumors which have malignant potential. Granular cell tumors in the abdominal wall are also rare. Since mesenchymal tumors are difficult to diagnose by imaging, further studies are needed to establish the diagnosis. PRESENTATION OF CASE: A 60-year-old asymptomatic woman underwent routine upper endoscopy and was found to have a gastric submucosal lesion. Computed tomography scan also showed an abdominal wall mass. The appearance of both lesions on imaging studies were similar, but it was unclear if the two lesions had the same origin. Endoscopic ultrasound-guided fine needle aspiration biopsy of the gastric lesion was insufficient to establish the diagnosis. Laparoscopic-endoscopic cooperative resection of the gastric lesion and ultrasound-guided core-needle biopsy of the abdominal wall mass enabled pathological diagnosis of both lesions. DISCUSSION: Diagnostic imaging findings of these two lesions were similar. Histologic and immunohistochemical studies are essential to establish a definitive diagnosis. Laparoscopic-endoscopic cooperative surgery may be an effective minimally invasive approach, allowing both pathological diagnosis and complete resection of a gastric submucosal tumor, especially when endoscopic-ultrasound guided fine needle aspiration or biopsy fails to make the diagnosis. CONCLUSION: Laparoscopic-endoscopic cooperative surgery can be an effective minimally invasive approach to resect some lesions. This is first report of the patient with a synchronous gastric leiomyoma and an intramuscular granular cell tumor in the abdominal wall.
  • Tsutomu Sugihara, Mitsuru Koizumi, Masamichi Koyama, Takashi Terauchi, Naoya Gomi, Yoshinori Ito, Kiyohiko Hatake, Naohiro Sata
    Annals of nuclear medicine 31 (10) 719 - 725 2017/12 
    BACKGROUND: This study aimed to compare the detection of bone metastases from breast cancer on F-18 fluorodeoxyglucose positron emission tomography (FDG-PET) and bone scintigraphy (BS). An explorative search for factors influencing the sensitivity or uptake of BS and FDG-PET was also performed. METHODS: Eighty-eight patients with bone metastases from breast cancer were eligible for this study. Histological confirmation of bone metastases was obtained in 31 patients. The bone metastases were visually classified into four types based on their computed tomography (CT) appearance: osteoblastic, osteolytic, mixed, and negative. The sensitivity of BS and FDG-PET were obtained regarding CT type, adjuvant therapy, and the primary tumor characteristics. The FDG maximum standardized uptake value (SUVmax) was analyzed. RESULTS: The sensitivities of the three modalities (CT, BS, and FDG-PET) were 77, 89, and 94%, respectively. The sensitivity of FDG-PET for the osteoblastic type (69%) was significantly lower than that for the other types (P < 0.001), and the sensitivity of BS for the negative type (70%) was significantly lower than that for the others. Regarding tumor characteristics, the sensitivity of FDG-PET significantly differed between nuclear grade (NG)1 and NG2-3 (P = 0.032). The SUVmax of the osteoblastic type was significantly lower than that of the other types (P = 0.009). The SUVmax of NG1 was also significantly lower than that of NG2-3 (P = 0.011). No significant difference in FDG uptake (SUVmax) was detected between different histological types. CONCLUSION: Although FDG-PET is superior to BS for the detection of bone metastases from breast cancer, this technique has limitations in depicting osteoblastic bone metastases and NG1.
  • Homare Ito, Hisanaga Horie, Ai Sadatomo, Daishi Naoi, Makiko Tahara, Yoshihiko Kono, Yoshiyuki Inoue, Koji Koinuma, Alan Kawarai Lefor, Naohiro Sata
    Journal of surgical case reports 2017 (12) rjx247  2017/12 [Refereed][Not invited]
     
    Metachronous solitary metacarpal bone metastasis from rectal cancer has not been reported previously. Here, we describe a 54-year-old woman who underwent abdominoperineal resection for rectal cancer following neoadjuvant chemoradiotherapy. The resected specimen contained adenocarcinoma with no lymph node metastases (Stage II, T3N0M0); no adjuvant chemotherapy was administered. Fifteen months after surgery, the patient presented with pain and swelling of the right thumb. Radiography revealed metacarpal bone destruction, and fluorine-18 fluorodeoxyglucose positron emission tomography showed uptake only in the metacarpal bone. Open biopsy revealed an adenocarcinoma, and a right thumb resection was performed. Histological examination indicated features of adenocarcinoma similar to the findings of a rectal lesion, leading to a diagnosis of metachronous solitary metacarpal bone metastasis from rectal cancer. The patient remains free of disease after 6 years of follow-up. Our findings suggest that surgical resection may lead to favorable outcomes in patients with resectable solitary bone metastases.
  • Yukio Iwashita, Taizo Hibi, Tetsuji Ohyama, Akiko Umezawa, Tadahiro Takada, Steven M Strasberg, Horacio J Asbun, Henry A Pitt, Ho-Seong Han, Tsann-Long Hwang, Kenji Suzuki, Yoo-Seok Yoon, In-Seok Choi, Dong-Sup Yoon, Wayne Shih-Wei Huang, Masahiro Yoshida, Go Wakabayashi, Fumihiko Miura, Kohji Okamoto, Itaru Endo, Eduardo de Santibañes, Mariano Eduardo Giménez, John A Windsor, O James Garden, Dirk J Gouma, Daniel Cherqui, Giulio Belli, Christos Dervenis, Daniel J Deziel, Eduard Jonas, Palepu Jagannath, Avinash Nivritti Supe, Harjit Singh, Kui-Hin Liau, Xiao-Ping Chen, Angus C W Chan, Wan Yee Lau, Sheung Tat Fan, Miin-Fu Chen, Myung-Hwan Kim, Goro Honda, Atsushi Sugioka, Koji Asai, Keita Wada, Yasuhisa Mori, Ryota Higuchi, Takeyuki Misawa, Manabu Watanabe, Naoki Matsumura, Toshiki Rikiyama, Naohiro Sata, Nobuyasu Kano, Hiromi Tokumura, Taizo Kimura, Seigo Kitano, Masafumi Inomata, Koichi Hirata, Yoshinobu Sumiyama, Kazuo Inui, Masakazu Yamamoto
    Journal of hepato-biliary-pancreatic sciences 24 (11) 591 - 602 2017/11 
    Bile duct injury (BDI) during laparoscopic cholecystectomy remains a serious iatrogenic surgical complication. BDI most often occurs as a result of misidentification of the anatomy; however, clinical evidence on its precise mechanism and surgeons' perceptions is scarce. Surgeons from Japan, Korea, Taiwan, and the USA, etc. (n = 614) participated in a questionnaire regarding their BDI experience and near-misses; and perceptions on landmarks, intraoperative findings, and surgical techniques. Respondents voted for a Delphi process and graded each item on a five-point scale. The consensus was built when ≥80% of overall responses were 4 or 5. Response rates for the first- and second-round Delphi were 60.6% and 74.9%, respectively. Misidentification of local anatomy accounted for 76.2% of BDI. Final consensus was reached on: (1) Effective retraction of the gallbladder, (2) Always obtaining critical view of safety, and (3) Avoiding excessive use of electrocautery/clipping as vital procedures; and (4) Calot's triangle area and (5) Critical view of safety as important landmarks. For (6) Impacted gallstone and (7) Severe fibrosis/scarring in Calot's triangle, bail-out procedures may be indicated. A consensus was reached among expert surgeons on relevant landmarks and intraoperative findings and appropriate surgical techniques to avoid BDI.
  • Ai Sadatomo, Yoshiyuki Inoue, Homare Ito, Tadayoshi Karasawa, Hiroaki Kimura, Sachiko Watanabe, Yoshiko Mizushina, Jun Nakamura, Ryo Kamata, Tadashi Kasahara, Hisanaga Horie, Naohiro Sata, Masafumi Takahashi
    Journal of immunology (Baltimore, Md. : 1950) The American Association of Immunologists 199 (9) 3306 - 3315 2017/11 [Refereed][Not invited]
     
    Accumulating evidence suggests that IL-1β plays a pivotal role in the pathophysiology of hepatic ischemia-reperfusion (I/R) injury; however, the mechanism by which I/R triggers IL-1β production in the liver remains unclear. Recent data have shown that neutrophils contribute to hepatic I/R injury independently of the inflammasomes regulating IL-1β maturation. Thus, we investigated the role of neutrophils in IL-1β maturation and tissue injury in a murine model of hepatic I/R. IL-1β was released from the I/R liver and its deficiency reduced reactive oxygen species generation, apoptosis, and inflammatory responses, such as inflammatory cell infiltration and cytokine expression, thereby resulting in reduced tissue injury. Depletion of either macrophages or neutrophils also attenuated IL-1β release and hepatic I/R injury. In vitro experiments revealed that neutrophil-derived proteinases process pro-IL-1β derived from macrophages into its mature form independently of caspase-1. Furthermore, pharmacological inhibition of serine proteases attenuated IL-1β release and hepatic I/R injury in vivo. Taken together, the interaction between neutrophils and macrophages promotes IL-1β maturation and causes IL-1β-driven inflammation in the I/R liver. Both neutrophils and macrophages are indispensable in this process. These findings suggest that neutrophil-macrophage interaction is a therapeutic target for hepatic I/R injury and may also provide new insights into the inflammasome-independent mechanism of IL-1β maturation in the liver.
  • Shin Saito, Misuzu Nakamura, Yoshinori Hosoya, Joji Kitayama, Alan Kawarai Lefor, Naohiro Sata
    Annals of medicine and surgery (2012) 22 34 - 38 2017/10 [Refereed][Not invited]
     
    BACKGROUND: Patients with esophageal cancer and a history of gastrectomy or concurrent gastric cancer undergo not only esophagectomy but also total gastrectomy. The goal of this study is to evaluate the postoperative quality of life (QOL) and dysfunction of these patients using two postoperative questionnaires. MATERIALS AND METHODS: From 1999 to 2015, 41 patients underwent concurrent esophagectomy and total gastrectomy. A jejunal pedicle with the subcutaneous supercharge technique was used for reconstruction. Patients were divided into two groups, including those undergoing concurrent esophagostomy and gastrectomy (Group 1), and those undergoing esophagectomy alone (Group 2, history of previous gastrectomy). Patients were analyzed by time interval, including patients within three years of surgery (Group A) and those more than three years after surgery (Group B). RESULTS: Eighteen patients completed the questionnaires. The mean DAUGS20 score was 26.4 ± 13.2. The DAUGS20 scores of groups 1 (N = 7) and 2 (N = 11) were 25.4 ± 12.5 and 27 ± 15.4 (p = 0.58), respectively. Global health status scored by the EORTC QLQC-30 were 71.4 ± 18.5 in group 1 and 67.4 ± 22.8 in group 2 (p = 0.85). DAUGS20 scores of group A (N = 10) and B (N = 8) were 28.1 ± 12.4 and 23.3 ± 14.4 (p = 0.35). No significant differences were found between groups A and B regarding the QLQ-C30 scores. CONCLUSION: DAUGS20 and QLQ-C30 scores showed no significant differences between groups 1 and 2 or groups A and B. These results suggest that postoperative QOL and dysfunction may be influenced more by current status than by surgical history and postoperative interval. Previous reports describe a DAUGS 20 score after gastrectomy of 27.8 and after esophagectomy of 36.1. The DAUGS20 score of these 18 patients is lower than DAUGS20 scores for patients undergoing either operation alone. Reconstruction using a subcutaneously placed jejunal segment seems to be reasonable.
  • Hidenori Tsukui, Rihito Kanamaru, Ai Sadatomo, Daishi Naoi, Tetsuichiro Shimizu, Makiko Tahara, Katsusuke Mori, Homare Ito, Mitsuaki Morimoto, Yoshihiko Kono, Yoshiyuki Inoue, Hiroyuki Maruyama, Koji Koinuma, Hisanaga Horie, Yasunaru Sakuma, Yoshinori Hosoya, Naohiro Sata, Joji Kitayama
    CANCER RESEARCH 77 0008-5472 2017/07
  • Shin Saito, Fernando Espinoza-Mercado, Hui Liu, Naohiro Sata, Xiaojiang Cui, Harmik J Soukiasian
    Cancer biology & therapy 18 (6) 359 - 368 1538-4047 2017/06 [Not refereed][Not invited]
     
    Lung cancer is the leading cause of cancer-related deaths worldwide with over 1 million deaths each year. The overall prognosis of lung cancer patients remains unsatisfactory, with a 5-year overall survival rate of less than 15%. Although most lung cancers are a result of smoking, approximately 25% of lung cancer cases worldwide are not attributable to tobacco use. Notably, more than half of the lung cancer cases in women occur in non-smokers. Among non-small-cell lung cancer (NSCLC) cases, cigarette-smokers have a greater association with squamous cell carcinoma than adenocarcinoma, which is more common in non-smokers. These findings imply that specific molecular and pathological features may associate with lung adenocarcinoma arising in non-smoker female patients. Over the past decade, whole genome sequencing and other '-omics' technologies led to the discovery of pathogenic mutations that drive tumor cell formation. These technological developments may enable tailored patient treatments throughout the course of their disease, potentially leading to improved patient outcomes. Some clinical and laboratory studies have shown success outcomes using epidermal growth factor receptor (EGFR) and anaplastic lymphoma kinase (ALK) tyrosine kinase inhibitors (TKI) in patients with EGFR mutations and ALK rearrangements, respectively. In fact, these 2 mutations are predominantly present in female non-smokers with adenocarcinoma. Immunotherapy has also recently emerged as a major therapeutic modality in NSCLC. In this review, we summarize the current understanding of NSCLC biology and new therapeutic molecular targets, focusing on the pathogenesis of non-smoker female NSCLC patients.
  • Joji Kitayama, Hironori Ishigami, Hironori Yamaguchi, Jun Yamada, Daisuke Soma, Hideyo Miyato, Takao Kamei, Alan Kawarai Lefor, Naohiro Sata
    Pleura and peritoneum 2 (2) 95 - 102 2017/06 
    Background: Repeated intraperitoneal (IP) administration of paclitaxel (PTX) with concurrent systemic chemotherapy is clinically effective for the treatment of peritoneal metastases (PM) from gastric cancer. However, it is unclear how biochemical modifications may affect the pharmacokinetics and bioavailability of IP administered PTX. Methods: In a xenograft PM model using human gastric cancer cells, MKN45, fluorescein-conjugated PTX (OG-PTX) was given IP and the intra-tumor distribution of PTX examined with fluorescein microscopy. Results: After IP injection, PTX was seen to directly infiltrate up to several hundred micrometers from the surface of the PM. Co-injection with 5 % non-animal stabilized hyaluronic acid increased PTX infiltration and suppressed the development of PM more efficiently than PTX alone. PTX solubilized with amphiphilic polymer composed of 2-methacryloyloxyethyl phosphorylcholine (MPC) and n-butyl methacrylate (BMA) efficiently formed a micellar formation 50-100 nm in diameter. IP injection of the nanomicellar PTX (PTX-30W) also showed significantly enhanced tumor infiltration and further inhibition of the growth of PM compared with PTX solubilized with Cremophor-ethanol (PTX-Cre). Finally, IP administration of NK105, another nanomicellar PTX, inhibited the growth of subcutaneous tumors as well as PM, compared with conventional PTX-Cre in the same murine model. Conclusions: PTX administered IP directly infiltrates PM and are thus a useful strategy for the treatment of PM. Drug modification with nanotechnology may further enhance penetration of PM resulting in improved clinical efficacy.
  • Shin Saito, Takao Nagashima, Daisuke Matsubara, Noriyoshi Fukushima, Masahiro Iwamoto, Seiji Minota, Hisanaga Horie, Yoshinori Hosoya, Alan Kawarai Lefor, Naohiro Sata
    INTERNATIONAL SURGERY 102 (5-6) 210 - 215 0020-8868 2017/05 [Refereed][Not invited]
     
    Eosinophilic granulomatosis with polyangiitis (EGPA) is a vascular disorder of unknown etiology characterized by severe asthma, eosinophilia, and granulomatous vasculitis. It is sometimes associated with gastrointestinal lesions, although perforations are uncommon. Corticosteroids are commonly used in the treatment of patients with EGPA; however, they may impair tissue repair and induce fibrotic changes in the vascular intima, which can lead to vascular occlusion, ischemia, and perforation. The anti-inflammatory properties of corticosteroids may mask symptoms of gastroduodenal ulcers or other intra-abdominal conditions, which can lead to a delay in diagnosis. From January 1, 2001 to December 31, 2014, 71 patients underwent surgery for small intestinal perforations. Of these, 4 operations were performed on 3 patients with EGPA who were receiving corticosteroids. We retrospectively reviewed the clinical and pathologic features of these patients. All 3 patients with EGPA were men, with a mean age of 56 years. The length of resected intestine ranged from 10 to 60 cm. Histopathologic examination revealed ulcers and perforations of the small intestine associated with vasculitis, compatible with EGPA. All patients had an uneventful postoperative course. Patients with EGPA presenting with abdominal pain must be carefully evaluated for possible intestinal perforation, especially those receiving corticosteroid therapy.
  • Yuichi Hirata, Takashi Kobayashi, Shin Nishiumi, Kodai Yamanaka, Takashi Nakagawa, Seiji Fujigaki, Takao Iemoto, Makoto Kobayashi, Takuji Okusaka, Shoji Nakamori, Masashi Shimahara, Takaaki Ueno, Akihiko Tsuchida, Naohiro Sata, Tatsuya Ioka, Yohichi Yasunami, Tomoo Kosuge, Takashi Kaneda, Takao Kato, Kazuhiro Yagihara, Shigeyuki Fujita, Tesshi Yamada, Kazufumi Honda, Takeshi Azuma, Masaru Yoshida
    Clinica chimica acta; international journal of clinical chemistry 468 98 - 104 2017/05 [Refereed][Not invited]
     
    BACKGROUND: To improve prognosis of pancreatic cancer (PC) patients, the discovery of more reliable biomarkers for the early detection is desired. METHODS: Blood samples were collected by 2 independent groups. The 1st set was included 55 early PC and 58 healthy volunteers (HV), and the 2nd set was included 16 PC and 16HV. The 16 targeted metabolites were quantitatively analyzed by gas chromatography/tandem mass spectrometry together with their corresponding stable isotopes. In the 1st set, the levels of these metabolites were evaluated, and diagnostic models were constructed via multivariate logistic regression analysis, leading to validation using the 2nd set. RESULTS: In the 1st set, model X consisting of 4 candidates based on our previous report possessed higher sensitivity (74.1%) than carbohydrate antigen 19-9 (CA19-9). Model Y, consisting of 2 metabolites newly selected from 16 metabolites via stepwise method possessed higher sensitivity (70.4%) than CA19-9. Furthermore, combining model Y with CA19-9 increased its sensitivity (90.7%) and specificity (89.5%). In the 2nd set, combining model Y with CA19-9 displayed high sensitivity (81.3%) and specificity (93.8%). In particular, it displayed very high sensitivity (100%) for resectable PC. CONCLUSIONS: Quantitative analysis confirmed that metabolomics-based diagnostic methods are useful for detecting PC early.
  • Yukio Iwashita, Taizo Hibi, Tetsuji Ohyama, Goro Honda, Masahiro Yoshida, Fumihiko Miura, Tadahiro Takada, Ho-Seong Han, Tsann-Long Hwang, Satoshi Shinya, Kenji Suzuki, Akiko Umezawa, Yoo-Seok Yoon, In-Seok Choi, Wayne Shih-Wei Huang, Kuo-Hsin Chen, Manabu Watanabe, Yuta Abe, Takeyuki Misawa, Yuichi Nagakawa, Dong-Sup Yoon, Jin-Young Jang, Hee Chul Yu, Keun Soo Ahn, Song Cheol Kim, In Sang Song, Ji Hoon Kim, Sung Su Yun, Seong Ho Choi, Yi-Yin Jan, Yan-Shen Shan, Chen-Guo Ker, De-Chuan Chan, Cheng-Chung Wu, King-Teh Lee, Naoyuki Toyota, Ryota Higuchi, Yoshiharu Nakamura, Yoshiaki Mizuguchi, Yutaka Takeda, Masahiro Ito, Shinji Norimizu, Shigetoshi Yamada, Naoki Matsumura, Junichi Shindoh, Hiroki Sunagawa, Takeshi Gocho, Hiroshi Hasegawa, Toshiki Rikiyama, Naohiro Sata, Nobuyasu Kano, Seigo Kitano, Hiromi Tokumura, Yuichi Yamashita, Goro Watanabe, Kunitoshi Nakagawa, Taizo Kimura, Tatsuo Yamakawa, Go Wakabayashi, Rintaro Mori, Itaru Endo, Masaru Miyazaki, Masakazu Yamamoto
    Journal of hepato-biliary-pancreatic sciences 24 (4) 191 - 198 2017/04 
    BACKGROUND: We previously identified 25 intraoperative findings during laparoscopic cholecystectomy (LC) as potential indicators of surgical difficulty per nominal group technique. This study aimed to build a consensus among expert LC surgeons on the impact of each item on surgical difficulty. METHODS: Surgeons from Japan, Korea, and Taiwan (n = 554) participated in a Delphi process and graded the 25 items on a seven-stage scale (range, 0-6). Consensus was defined as (1) the interquartile range (IQR) of overall responses ≤2 and (2) ≥66% of the responses concentrated within a median ± 1 after stratification by workplace and LC experience level. RESULTS: Response rates for the first and the second-round Delphi were 92.6% and 90.3%, respectively. Final consensus was reached for all the 25 items. 'Diffuse scarring in the Calot's triangle area' in the 'Factors related to inflammation of the gallbladder' category had the strongest impact on surgical difficulty (median, 5; IQR, 1). Surgeons agreed that the surgical difficulty increases as more fibrotic change and scarring develop. The median point for each item was set as the difficulty score. CONCLUSIONS: A Delphi consensus was reached among expert LC surgeons on the impact of intraoperative findings on surgical difficulty.
  • Atsushi Ito, Yuto Yamazaki, Hironobu Sasano, Daisuke Matsubara, Noriyoshi Fukushima, Mio Tamba, Kenichi Tabata, Kentaro Ashizawa, Akihito Takei, Masaru Koizumi, Yasunaru Sakuma, Naohiro Sata, Hisashi Oshiro
    Pathology international 67 (4) 214 - 221 1320-5463 2017/04 [Refereed][Not invited]
     
    Unilateral multiple adrenocortical micronodules (UMNs) constitute a rare subset of primary aldosteronism (PA) characterized by the hypersecretion of aldosterone derived from multiple small nodules in the zona glomerulosa of the unilateral adrenal grand. This case study describes a 49-year-old man with PA and UMNs who presented with muscle cramps at rest due to hypokalemia. The patient had a 6-year history of hypertension treated with antihypertensive drugs. Imaging studies revealed bilateral adrenal nodules as large as 5 mm. Adrenal venous sampling confirmed unilateral PA; therefore, the patient underwent the removal of the affected adrenal gland. Macroscopically, the removed adrenal gland exhibited irregular adrenocortical thickening accompanied by ill-defined, adrenocortical macronodules as large as 6 mm. The zona glomerulosa was histologically hyperplastic. However, an immunohistochemistry test of the steroidogenic enzymes revealed that these macronodules and the hyperplastic glomerular layer tested negative for CYB11B2. Moreover, we observed adrenocortical micronodules as large as 0.5 mm that tested immunohistochemically positive for CYP11B2 and HSD3B2 but negative for CYP17A1 and CYP11B1. Thus, UMNs were diagnosed. This case instructively indicates that a grossly or histologically detectable nodular lesion is not necessarily a culprit lesion for PA. Therefore, functional histopathology is indispensable for the correct subclassification of PA.
  • Shin Saito, Yoshinori Hosoya, Hirofumi Fujii, Hideyuki Ohzawa, Akira Tanaka, Joji Kitayama, Alan Kawarai Lefor, Naohiro Sata
    International Surgery 102 (3-4) 137 - 140 0020-8868 2017/03 
    Gastric cancer is a common malignancy and remains potentially lethal. The prognosis of patients with stage IV gastric cancer is thought to be poor, but new molecular targeted therapy may benefit patients with advanced gastric cancer. Currently, conversion surgery after chemotherapy with a trastuzumab-containing regimen is reported to be effective in these patients. We present 3 patients with human epidermal growth factor receptor 2 (HER2)–positive advanced gastric cancer who underwent conversion surgery after receiving a trastuzumab-containing chemotherapy regimen. Interestingly, the primary lesion acquired resistance to the trastuzumab-containing regimen, although the metastatic lesions maintained a complete response. The reason why the primary lesions became resistant to trastuzumab remains unclear. More studies are needed to clarify the mechanism of resistance. Conversion surgery, made possible by the use of molecular-targeted therapy, may improve the prognosis of patients with stage IV gastric cancer, particularly if metastatic lesions show a complete response to therapy.
  • Shin Saito, Yoshinori Hosoya, Misuzu Nakamura, Takashi Ui, Kentaro Kurashina, Shiro Matsumoto, Rihito Kanamru, Joji Kitayama, Alan Lefor, Naohiro Sata
    ANNALS OF BEHAVIORAL MEDICINE 51 S1877 - S1878 0883-6612 2017/03 [Not refereed][Not invited]
  • Kohei Morita, Kumiko Mito, Hisashi Oshiro, Naohiro Sata, Toshiro Niki, Noriyoshi Fukushima
    LABORATORY INVESTIGATION 97 447A - 448A 0023-6837 2017/02 [Refereed][Not invited]
  • Kumiko Mito, Michihiro Saito, Kohei Morita, Iruru Maetam, Naohiro Sata, Noriyoshi Fukushima
    MODERN PATHOLOGY 30 447A - 447A 0893-3952 2017/02 [Refereed][Not invited]
  • Kohei Morita, Kumiko Mito, Hisashi Oshiro, Naohiro Sata, Toshiro Niki, Noriyoshi Fukushima
    MODERN PATHOLOGY 30 447A - 448A 0893-3952 2017/02 [Refereed][Not invited]
  • Kumiko Mito, Michihiro Saito, Kohei Morita, Iruru Maetani, Naohiro Sata, Noriyoshi Fukushima
    LABORATORY INVESTIGATION 97 447A - 447A 0023-6837 2017/02 [Refereed][Not invited]
  • Hidenori Tsukui, Koji Koinuma, Mitsuaki Morimoto, Hisanaga Horie, Alan Kawarai Lefor, Yuka Kagaya, Haruo Takahashi, Tomonori Yano, Daisuke Matsubara, Hironori Yamamoto, Naohiro Sata
    Clinical journal of gastroenterology シュプリンガー・ジャパン(株) 10 (1) 32 - 36 1865-7257 2017/02 [Not refereed][Not invited]
     
    We report the case of a patient with Crohn's disease who initially presented with a ceco-urachal fistula. The patient was a 31-year-old female who underwent an appendectomy 6 years before presenting to our institution. She had a one-year history of diarrhea, and had recently developed polyuria and a sensation of residual urine. She was admitted with fever and lower abdominal pain. Endoscopy and computed tomography revealed a ceco-urachal fistula, which was consistent with Crohn's disease. An urachal resection was performed, which included partial cystectomy and ileocecal resection. A ceco-urachal fistula is a rare initial symptom of Crohn's disease. During the surgical management of such cases, it is necessary to resect the urachus, the affected portion of the bladder, the fistula, and the affected part of the digestive tract in order to avoid recurrence.
  • Yasunaru Sakuma, Yoshikazu Yasuda, Naohiro Sata, Yoshinori Hosoya, Atsushi Shimizu, Hirofumi Fujii, Daisuke Matsubara, Noriyuki Fukushima, Atsushi Miki, Misato Maeno, Alan Kawarai Lefor
    BMC cancer 17 (1) 37 - 37 1471-2407 2017/01 [Refereed][Not invited]
     
    BACKGROUND: Long-term term survival in patients with pancreatic neuroendocrine tumors has been reported, even in patients with metastatic disease. Metastases to the spleen are extremely rare, but have been reported from a number of primary malignancies, such as breast cancer, lung cancer, melanoma and ovarian cancer. This is the first report of a splenic metastasis from a primary pancreatic neuroendocrine tumor. CASE PRESENTATION: The patient presented as a 53 years old white male with anemia and fatigue. Physical examination revealed a left upper quadrant fullness and computed tomography showed a 24 cm left upper quadrant mass with multiple liver metastases, splenomegaly and a 1 cm mass in the spleen. Resection of the primary pancreatic tumor (T4N0M1) was accompanied by gastrectomy, splenectomy and resection of adherent bowel. The spleen contained a metastatic lesion 1.0 cm in diameter, consistent with a primary neuroendocrine tumor of the pancreas. This operation was followed 8 months later, by delayed resection of liver metastases. The patient receives monthly administration of somatostatin long-acting analogue and has undergone several ablations of liver lesions with percutaneous radiofrequency ablation as well as a second liver resection. The patient is alive seven years after initial presentation, with no evidence of disease on imaging studies. CONCLUSIONS: This is the first report of a splenic metastasis from a primary pancreatic neuroendocrine tumor. The patient initially presented with synchronous multiple liver metastases and a single splenic metastasis. After resection of the primary tumor and spleen, the patient has undergone aggressive cytoreductive surgery/ablation of liver lesions and somatostatin therapy with resulting long-term survival.
  • Taizo Hibi, Yukio Iwashita, Tetsuji Ohyama, Goro Honda, Masahiro Yoshida, Tadahiro Takada, Ho-Seong Han, Tsann-Long Hwang, Satoshi Shinya, Kenji Suzuki, Akiko Umezawa, Yoo-Seok Yoon, In-Seok Choi, Wayne Shih-Wei Huang, Kuo-Hsin Chen, Fumihiko Miura, Manabu Watanabe, Yuta Abe, Takeyuki Misawa, Yuichi Nagakawa, Dong-Sup Yoon, Jin-Young Jang, Hee Chul Yu, Keun Soo Ahn, Song Cheol Kim, In Sang Song, Ji Hoon Kim, Sung Su Yun, Seong Ho Choi, Yi-Yin Jan, Shyr-Ming Sheen-Chen, Yan-Shen Shan, Chen-Guo Ker, De-Chuan Chan, Cheng-Chung Wu, Naoyuki Toyota, Ryota Higuchi, Yoshiharu Nakamura, Yoshiaki Mizuguchi, Yutaka Takeda, Masahiro Ito, Shinji Norimizu, Shigetoshi Yamada, Naoki Matsumura, Junichi Shindoh, Hiroki Sunagawa, Takeshi Gocho, Hiroshi Hasegawa, Toshiki Rikiyama, Naohiro Sata, Nobuyasu Kano, Seigo Kitano, Hiromi Tokumura, Yuichi Yamashita, Goro Watanabe, Kunitoshi Nakagawa, Taizo Kimura, Tatsuo Yamakawa, Go Wakabayashi, Itaru Endo, Masaru Miyazaki, Masakazu Yamamoto
    Journal of hepato-biliary-pancreatic sciences 24 (1) 24 - 32 2017/01 
    BACKGROUND: Generally, surgeons' perceptions of surgical safety are based on experience and institutional policy. Our recent pilot survey demonstrated that the acceptable duration of surgery and criteria for open conversion during laparoscopic cholecystectomy (LC) vary among workplaces. METHODS: A web-based survey was distributed to 554 expert LC surgeons in Japan, Korea, and Taiwan. The questionnaire covered LC experience, safety measures and recognition of landmarks, decision-making regarding conversion to open/partial cholecystectomy and the implications of this decision. Overall responses were compared among nations, and then stratified by LC experience level (lifetime cases 200-499, 500-999, and ≥1,000). RESULTS: The response rate was 92.6% (513/554); 67 surgeons with ≤199 LCs were excluded, and responses from 446 surgeons were analyzed. We observed significant differences among nations on almost all questions. Differences that remained after stratification by LC experience were on questions related to acceptable duration of surgery, adoption rates of intraoperative cholangiography, the "critical view of safety" technique, identification of Rouvière's sulcus, recognition of the SS-Inner layer theory, and intraoperative judgment to abandon conventional LC. CONCLUSIONS: Even among experts, surgeons' perceptions during LC are workplace-dependent. A novel grading system of surgical difficulty and standardized LC procedures are paramount to generate high-level evidence.
  • Yasunaru Sakuma, Naohiro Sata, Kazuhiro Endo, Yoshikazu Yasuda, Shinichiro Yokota, Yoshinori Hosoya, Atsushi Shimizu, Hirofumi Fujii, Daisuke Matsubara, Noriyoshi Fukushima, Shoko Asakawa, Yuuki Kawarai Shimada, Chieko Kawarai Lefor, Alan Kawarai Lefor
    International journal of surgery case reports 41 169 - 173 2210-2612 2017 [Refereed][Not invited]
     
    INTRODUCTION: Pancreatic neuroendocrine tumors are rare. Treatment includes aggressive local management of the primary lesion and metastases, and systemic somatostatin. This is the first report of an isolated metachronous metastasis to the adrenal gland from a pancreatic neuroendocrine tumor that presented 90 months after the primary tumor. PRESENTATION OF CASE: The patient presented as a 53yo man with a left upper quadrant mass and synchronous metastases to the spleen and liver (pancreatic neuroendocrine tumor T4N0M1, Stage IV), which were resected (CD56-, synaptophysin+, chromogranin+, Ki-67<1%). Over the next 90 months, he underwent five procedures to treat hepatic recurrences (2 liver resections and 3 percutaneous radiofrequency ablations). Serum PIVKA levels were elevated prior to treatment of four of six lesions and returned to baseline after therapy. He presents now, asymptomatic, with a right adrenal mass found on routine imaging and no other lesions. Serum PIVKA was elevated to 44mg/dL. The adrenal gland was resected and shown to be a metastasis (CD56+, synaptophysin+, chromogranin+, Ki-67 15-20%). DISCUSSION: This patient's clinical course reflects aggressive local therapy of the primary lesion and multiple metastatic lesions to three organs (liver, spleen, adrenal) over nearly eight years. The utility of serum PIVKA levels in patients with pancreatic neuroendocrine tumors is not previously reported and needs further investigation. CONCLUSION: This patient has a pancreatic neuroendocrine tumor with metastases to the spleen, liver and adrenal gland and elevated PIVKA levels with recurrent disease. These unique clinical features add to the diversity of clinical presentation of these rare tumors.
  • Kazuhiro Endo, Dai Kujirai, Hinako Maeda, Takashi Ishida, Toshiaki Terauchi, Masaru Kimata, Hiroharu Shinozaki, Alan Kawarai Lefor, Naohiro Sata
    Asian journal of endoscopic surgery 9 (4) 270 - 274 2016/11 
    INTRODUCTION: The aim of this study was to compare the clinical outcomes of single-incision transumbilical laparoscopy-assisted appendectomy performed by surgical residents and attending surgeons. METHODS: We reviewed the clinical outcomes of 131 transumbilical laparoscopy-assisted appendectomies performed from January 2011 to June 2014. During the study period, 13 residents and 6 board-certified attending surgeons performed the procedures. For all operations performed by residents and attending surgeons, we reviewed and compared gender, age, BMI, body temperature, white blood cell count, C-reactive protein serum level, and the presence of a fecalith or abscess. Clinical outcomes including operative time, estimated blood loss, need for additional ports, conversion to open surgery, intraoperative complications, postoperative complications, and postoperative hospital stay were compared between the two groups. RESULTS: The mean preoperative white blood cell count in the resident-operated group was significantly higher than in the attending-operated group (14.0 vs 10.8 ×103 /mm3 , P = 0.007). There were no other significant differences in clinical variables between the two groups. Outcomes show that estimated blood loss was significantly higher (23.4 vs 9.8 mL, P = 0.031) and operative time tended to be longer (86.0 vs 72.0 min, P = 0.056) in the resident-operated group. No other significant differences were observed. CONCLUSION: Transumbilical laparoscopy-assisted appendectomy performed by residents is feasible and safe. It is an acceptable as a part of routine surgical training.
  • Hisanaga Horie, Homare Ito, Takahiro Sasaki, Ai Sadatomo, Yoshihiko Kono, Makiko Tahara, Mitsuaki M. M. Morimoto, Koji Koinuma, Alan T. Lefor, Naohiro Sata
    JOURNAL OF THE AMERICAN COLLEGE OF SURGEONS 223 (4) E8 - E9 1072-7515 2016/10 [Not refereed][Not invited]
  • Yukihiro Sanada, Yasunaru Sakuma, Hideki Sasanuma, Atsushi Miki, Takumi Katano, Yuta Hirata, Noriki Okada, Naoya Yamada, Yoshiyuki Ihara, Taizen Urahashi, Naohiro Sata, Yoshikazu Yasuda, Koichi Mizuta
    World journal of gastroenterology 22 (34) 7851 - 6 2219-2840 2016/09 [Refereed][Not invited]
     
    Utilizing the opened round ligament as venous grafts during liver transplantation is useful but controversial, and there are no pathological analyses of this procedure. Herein, we describe the first reported case of a pathological analysis of an opened round ligament used as a venous patch graft in a living donor liver transplantation (LDLT). A 13-year-old female patient with biliary atresia underwent LDLT using a posterior segment graft from her mother. The graft had two hepatic veins (HVs), which included the right HV (RHV; 15 mm) and the inferior RHV (IRHV; 20 mm). The graft RHV and IRHV were formed into a single orifice using the donor's opened round ligament (60 mm × 20 mm) as a patch graft during bench surgery; it was then anastomosed end-to-side with the recipient inferior vena cava. The recipient had no post-transplant complications involving the HVs, but she died of septic shock with persistent cholangitis and jaundice 86 d after LDLT. The HV anastomotic site had no stenosis or thrombus on autopsy. On pathology, there was adequate patency and continuity between the recipient's HV and the donor's opened round ligament. In addition, the stains for CD31 and CD34 on the inner membrane of the opened round ligament were positive. Hepatic venous reconstruction using the opened round ligament as a venous patch graft is effective in LDLT, as observed on pathology.
  • Yukio Iwashita, Tetsuji Ohyama, Goro Honda, Taizo Hibi, Masahiro Yoshida, Fumihiko Miura, Tadahiro Takada, Ho-Seong Han, Tsann-Long Hwang, Satoshi Shinya, Kenji Suzuki, Akiko Umezawa, Yoo-Seok Yoon, In-Seok Choi, Wayne Shih-Wei Huang, Kuo-Hsin Chen, Manabu Watanabe, Yuta Abe, Takeyuki Misawa, Yuichi Nagakawa, Dong-Sup Yoon, Jin-Young Jang, Hee Chul Yu, Keun Soo Ahn, Song Cheol Kim, In Sang Song, Ji Hoon Kim, Sung Su Yun, Seong Ho Choi, Yi-Yin Jan, Shyr-Ming Sheen-Chen, Yan-Shen Shan, Chen-Guo Ker, De-Chuan Chan, King-Teh Lee, Naoyuki Toyota, Ryota Higuchi, Yoshiharu Nakamura, Yoshiaki Mizuguchi, Yutaka Takeda, Masahiro Ito, Shinji Norimizu, Shigetoshi Yamada, Naoki Matsumura, Junichi Shindoh, Hiroki Sunagawa, Hiroshi Hasegawa, Toshiki Rikiyama, Naohiro Sata, Nobuyasu Kano, Seigo Kitano, Hiromi Tokumura, Yuichi Yamashita, Goro Watanabe, Kunitoshi Nakagawa, Taizo Kimura, Tatsuo Yamakawa, Go Wakabayashi, Itaru Endo, Masaru Miyazaki, Masakazu Yamamoto
    Journal of hepato-biliary-pancreatic sciences 23 (9) 533 - 47 2016/09 
    BACKGROUND: Serious complications continue to occur in laparoscopic cholecystectomy (LC). The commonly used indicators of surgical difficulty such as the duration of surgery are insufficient because they are surgeon and institution dependent. We aimed to identify appropriate indicators of surgical difficulty during LC. METHODS: A total of 26 Japanese expert LC surgeons discussed using the nominal group technique (NGT) to generate a list of intraoperative findings that contribute to surgical difficulty. Thereafter, a survey was circulated to 61 experts in Japan, Korea, and Taiwan. The questionnaire addressed LC experience, surgical strategy, and perceptions of 30 intraoperative findings listed by the NGT. RESULTS: The response rate of the survey was 100%. There was a statistically significant difference among nations regarding the duration of surgery and adoption rate of safety measures and recognition of landmarks. The criteria for conversion to an open or subtotal cholecystectomy were at the discretion of each surgeon. In contrast, perceptions of the impact of 30 intraoperative findings on surgical difficulty (categorized by factors related to inflammation and additional findings of the gallbladder and other intra-abdominal factors) were consistent among surgeons. CONCLUSIONS: Intraoperative findings are objective and considered to be appropriate indicators of surgical difficulty during LC.
  • Katsuhiko Uesaka, Narikazu Boku, Akira Fukutomi, Yukiyasu Okamura, Masaru Konishi, Ippei Matsumoto, Yuji Kaneoka, Yasuhiro Shimizu, Shoji Nakamori, Hirohiko Sakamoto, Soichiro Morinaga, Osamu Kainuma, Koji Imai, Naohiro Sata, Shoichi Hishinuma, Hitoshi Ojima, Ryuzo Yamaguchi, Satoshi Hirano, Takeshi Sudo, Yasuo Ohashi
    Lancet (London, England) 388 (10041) 248 - 57 2016/07 
    BACKGROUND: Although adjuvant chemotherapy with gemcitabine is standard care for resected pancreatic cancer, S-1 has shown non-inferiority to gemcitabine for advanced disease. We aimed to investigate the non-inferiority of S-1 to gemcitabine as adjuvant chemotherapy for pancreatic cancer in terms of overall survival. METHODS: We did a randomised, open-label, multicentre, non-inferiority phase 3 trial undertaken at 33 hospitals in Japan. Patients who had histologically proven invasive ductal carcinoma of the pancreas, pathologically documented stage I-III, and no local residual or microscopic residual tumour, and were aged 20 years or older were eligible. Patients with resected pancreatic cancer were randomly assigned (in a 1:1 ratio) to receive gemcitabine (1000 mg/m(2), intravenously administered on days 1, 8, and 15, every 4 weeks [one cycle], for up to six cycles) or S-1 (40 mg, 50 mg, or 60 mg according to body-surface area, orally administered twice a day for 28 days followed by a 14 day rest, every 6 weeks [one cycle], for up to four cycles) at the data centre by a modified minimisation method, balancing residual tumour status, nodal status, and institutions. The primary outcome was overall survival in the two treatment groups, assessed in the per-protocol population, excluding ineligible patients and those not receiving the allocated treatment. The protocol prespecified that the superiority of S-1 with respect to overall survival was also to be assessed in the per-protocol population by a log-rank test, if the non-inferiority of S-1 was verified. We estimated overall and relapse-free survival using the Kaplan-Meier methods, and assessed non-inferiority of S-1 to gemcitabine using the Cox proportional hazard model. The expected hazard ratio (HR) for mortality was 0.87 with a non-inferiority margin of 1.25 (power 80%; one-sided type I error 2.5%). This trial is registered at UMIN CTR (UMIN000000655). FINDINGS: 385 patients were randomly assigned to treatment between April 11, 2007, and June 29, 2010 (193 to the gemcitabine group and 192 to the S-1 group). Of these, three were exlcuded because of ineligibility and five did not receive chemotherapy. The per-protocol population therefore consisted of 190 patients in the gemcitabine group and 187 patients in the S-1 group. On Sept 15, 2012, following the recommendation from the independent data and safety monitoring committee, this study was discontinued because the prespecified criteria for early discontinuation were met at the interim analysis for efficacy, when all the protocol treatments had been finished. Analysis with the follow-up data on Jan 15, 2016, showed HR of mortality was 0.57 (95% CI 0.44-0.72, pnon-inferiority<0.0001, p<0.0001 for superiority), associated with 5-year overall survival of 24.4% (18.6-30.8) in the gemcitabine group and 44.1% (36.9-51.1) in the S-1 group. Grade 3 or 4 leucopenia, neutropenia, aspartate aminotransferase, and alanine aminotransferase were observed more frequently in the gemcitabine group, whereas stomatitis and diarrhoea were more frequently experienced in the S-1 group. INTERPRETATION: Adjuvant chemotherapy with S-1 can be a new standard care for resected pancreatic cancer in Japanese patients. These results should be assessed in non-Asian patients. FUNDING: Pharma Valley Center, Shizuoka Industrial Foundation, Taiho Pharmaceutical.
  • Hideyuki Ohzawa, Kentaro Kurashina, Atsushi Miki, Yasunari Okuda, Misuzu Mori, Masuzu Ueda, Yoshinori Hosoya, Joji Kitayama, Naohiro Sata, Hirofumi Fujii
    ANNALS OF ONCOLOGY 27 0923-7534 2016/07 [Not refereed][Not invited]
  • Akira Kurogochi, Naohiro Sata, Masaru Koizumi, Hideki Sasanuma, Yoshikazu Yasuda
    PANCREAS 45 (6) 921 - 921 0885-3177 2016/07 [Not refereed][Not invited]
  • Masatake Taniguchi, Misuzu Mori, Naohiro Sata, Hirofumi Fujii
    Japanese Journal of Cancer and Chemotherapy 43 (6) 757 - 759 0385-0684 2016/06 [Refereed][Not invited]
     
    A 61-year-old woman underwent surgical resection of rectal cancer (SI, N3, Stage Kb) and received 12 courses of adjuvant mFOLFOX6 chemotherapy. Six months after completion of adjuvant chemotherapy, she was found to have pulmonary metastases, and was treated with FOLFIRI plus bevacizumab. After 6 courses of chemotherapy, the pulmonary nodules showed central cavitation without any change in size. After 6 additional courses of chemotherapy, pulmonary lesions increased in and had consolidated. She was treated with regorafenib as second-line chemotherapy for recurrent disease. After 6 courses of regorafenib, the pulmonary nodules became cavitated. According to the RECIST criteria, the tumor response was stable disease. However, the morphology was significantly changed and tumor growth had been controlled for a long time. Assessment of tumor response depends not only on size according to the RECIST criteria, but also on the morphologic response when we assess tumor response to molecular targeted drugs.
  • Homare Ito, Yasuyuki Miyakura, Hidenori Tsukui, Daishi Naoi, Makiko Tahara, Mitsuaki Morimoto, Koji Koinuma, Hisanaga Horie, Alan Kawarai Lefor, Naohiro Sata
    Journal of surgical case reports 2016 (5) 2016/05 [Refereed][Not invited]
     
    Metastatic squamous cell carcinoma (SCC) from an unknown primary site to the colon has not been reported previously. A 75-year-old woman presented with a mass in the left submandibular region. Biopsy revealed a Class V lesion, but the histologic type was undetermined. Surgical resection of the left submandibular gland with cervical lymph node dissection was performed. However, SCC was seen in the lymph nodes only, with no tumor in the submandibular gland. Three months after surgery, computed tomography revealed that the preoperatively diagnosed lesion in the transverse colon had grown considerably. A laparoscopic right hemicolectomy was performed. Histological examination showed features of SCC, similar to the findings in the cervical lymph nodes. We report a rare case of synchronous metastatic SCC to the colon and cervical lymph nodes from a carcinoma of unknown primary site.
  • Y. Sakuma, H. Sasanuma, A. Miki, A. Shimizu, N. Sata, Y. Yasuda, A. K. Lefor, Y. Hirata, N. Yamada, N. Okada, Y. Sanada, Y. Ihara, T. Urahashi, K. Mizuta
    Transplantation Proceedings 48 (4) 1110 - 1114 1873-2623 2016/05 [Refereed][Not invited]
     
    Background In small infants, left lateral segment grafts are sometimes too large to overcome the problems of large-for-size grafts in the abdominal compartment. To address this problem, we have developed a safe living donor graftectomy for neonates, a so-called "S2 monosegment graft" to minimize graft thickness. We reviewed our single-center experience to evaluate the feasibility of this technique for reducing graft size. Methods Eleven living-donor liver transplants using S2 monosegment grafts were performed between October 2008 and September 2014 at our institution. Medical records of both donors and recipients were reviewed and data collected retrospectively. Results The mean age of recipients at the time of transplantation was 125.3 days, including 3 neonates. The average S2 monosegment graft weight was 127.4 g, and the graft-to-recipient body weight ratio was successfully reduced to 3.5%. The graft livers were reduced to 4.1 cm in thickness. Two recipients with grafts larger than 5 cm could not undergo primary abdominal closure. Portal vein stenosis and biliary stenosis was observed in 1 recipient, and hepatic artery complications were seen in 2 recipients the clinical course for all donors were uneventful. Liver regeneration was seen in every patient. The graft and patient 1-year survival rate was 100%. Conclusions Living-donor liver transplantation using S2 monosegment grafts offers a safe and useful option for treating smaller infants. Here, we introduce our method of S2 monosegment graft emphasizing the donor harvest and graft thickness.
  • Masanobu Taguchi, Katsuya Dezaki, Masaru Koizumi, Kentaro Kurashina, Yoshinori Hosoya, Alan Kawarai Lefor, Naohiro Sata, Toshihiko Yada
    Surgery 159 (5) 1342 - 50 0039-6060 2016/05 [Refereed][Not invited]
     
    BACKGROUND: Decrease in appetite and weight after total gastrectomy in patients with gastric cancer leads to a decrease in quality of life, increased mortality, and may necessitate discontinuation of adjuvant chemotherapy. The aim of this study is to determine whether rikkunshito, a Japanese herbal medicine, increases food intake and weight after gastrectomy in rats. METHODS: Male rats underwent gastrectomy followed by roux-en-Y reconstruction or sham operation and were then treated with rikkunshito for 14 days starting on postoperative day 3. Daily food intake, weight, plasma glucagon-like peptide-1 (GLP-1), and ghrelin levels were measured. A pilot study to measure pre- and postoperative plasma GLP-1 levels was conducted in patients who underwent total gastrectomy for gastric cancer. RESULTS: Administration of rikkunshito after gastrectomy in rats significantly increased food intake and weight, which continued for at least 2 weeks after treatment. Both fasting and postprandial plasma GLP-1 levels were increased markedly after gastrectomy compared with sham-operated animals. Increased GLP-1 levels in rats after gastrectomy were suppressed markedly by rikkunshito. rikkunshito had no significant effect on plasma ghrelin levels after gastrectomy. Treatment with a GLP-1 receptor antagonist significantly improved food intake and weight after gastrectomy. Plasma fasting GLP-1 levels in patients with gastric cancer were increased greatly after gastrectomy on postoperative day 1. CONCLUSION: Administration of rikkunshito suppresses plasma GLP-1 levels after total gastrectomy, which is associated with recovery from reduced food intake and weight in rats.
  • Kazufumi Honda, Michimoto Kobayashi, Takuji Okusaka, Chigusa Morizane, Jo Ann Rinaudo, Ying Huang, Tracey Marsh, Masashi Shimahara, Takaaki Ueno, Akihiko Tsuchida, Naohiro Sata, Tatsuya Ioka, Tomoo Kosuge, Yohichi Yasunami, Masaru Yoshida, Takeshi Azuma, Sudhir Srivastava, Tesshi Yamada
    JOURNAL OF CLINICAL ONCOLOGY 34 (15) 0732-183X 2016/05 [Not refereed][Not invited]
  • Mitsuaki Morimoto, Koji Koinuma, Alan K Lefor, Hisanaga Horie, Homare Ito, Naohiro Sata, Yoshikazu Hayashi, Keijiro Sunada, Hironori Yamamoto
    World journal of gastrointestinal endoscopy 8 (8) 374 - 7 2016/04 [Refereed][Not invited]
     
    A 48-year-old man underwent laparoscopic sigmoid colon resection for cancer and surveillance colonoscopy was performed annually thereafter. Five years after the resection, a submucosal mass was found at the anastomotic staple line, 15 cm from the anal verge. Computed tomography scan and endoscopic ultrasound were not consistent with tumor recurrence. Endoscopic mucosa biopsy was performed to obtain a definitive diagnosis. Mucosal incision over the lesion with the cutting needle knife technique revealed a creamy white material, which was completely removed. Histologic examination showed fibrotic tissue without caseous necrosis or tumor cells. No bacteria, including mycobacterium, were found on culture. The patient remains free of recurrence at five years since the resection. Endoscopic biopsy with a cutting mucosal incision is an important technique for evaluation of submucosal lesions after rectal resection.
  • Masanobu Taguchi, Katsuya Dezaki, Masaru Koizumi, Kentaro Kurashina, Yoshinori Hosoya, Yasunaru Sakuma, Hisanaga Horie, Joji Kitayama, Clarence Foster, Alan K. Lefor, Naohiro Sata, Toshihiko Yada
    GASTROENTEROLOGY 150 (4) S1197 - S1197 0016-5085 2016/04 [Not refereed][Not invited]
  • Saito Shin, Kurashina Kentaro, Matsumoto Shiro, Sakuma Yasunaru, Minota Seiji, Iwamoto Masahiro, Matsubara Daisuke, Fukushima Noriyoshi, Horie Hisanaga, Hosoya Yoshinori, Lefor Alan K, Sata Naohiro
    JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY 137 (2) AB165  0091-6749 2016/02 [Refereed][Not invited]
  • KOMATSUBARA Toshihide, KOINUMA Koji, MIYAKURA Yasuyuki, MIYAKURA Yasuyuki, HORIE Hisanaga, MORIMOTO Mitsuaki, ITO Homare, LEFOR Alan K, SATA Naohiro, FUKUSHIMA Noriyoshi
    Clinical Journal of Gastroenterology (Web) 9 (1) 1‐6 (WEB ONLY)  1865-7265 2016/02 [Not refereed][Not invited]
  • Toshihide Komatsubara, Koji Koinuma, Yasuyuki Miyakura, Hisanaga Horie, Mitsuaki Morimoto, Homare Ito, Alan K Lefor, Naohiro Sata, Noriyoshi Fukushima
    Clinical journal of gastroenterology 9 (1) 1 - 6 1865-7257 2016/02 [Refereed][Not invited]
     
    PURPOSE: Endocrine cell carcinoma, according to the Japanese classification criteria for colorectal cancer, corresponds to neuroendocrine carcinoma (NEC) and mixed adenoneuroendocrine carcinoma (MANEC), as defined in the 2010 World Health Organization (WHO) classification. We retrospectively reviewed the clinical features of patients with these tumors diagnosed and treated at our institution. METHODS: The clinicopathological features of endocrine cell carcinomas of the colon and rectum diagnosed by neuroendocrine markers from January 2000 to December 2012 were retrospectively evaluated in 12 patients. RESULTS: Surgical specimens were obtained from eight of the 12 patients. MANEC was diagnosed in six patients and NEC in one. One tumor was unclassifiable. The tumors were not resected in four patients, and all died within 3 months. Of the eight patients who underwent resection, four received an R0 resection, two of whom underwent adjuvant chemotherapy and survived more than 5 years. One patient who underwent an R2 resection and continuous chemotherapy survived for 53 months. One patient with NEC underwent surgery and radiotherapy, and died 17 months later. CONCLUSION: Most endocrine cell carcinomas of the colon and rectum reviewed were MANECs. Though their prognosis was generally poor, chemotherapy may be effective in some patients.
  • Ai Sadatomo, Koji Koinuma, Hisanaga Horie, Alan K Lefor, Naohiro Sata
    Annals of medicine and surgery (2012) 5 19 - 22 2016/02 [Refereed][Not invited]
     
    INTRODUCTION: Isolated vaginal metastases from colorectal cancer are extremely rare. There are only a few reported cases in the English literature, and the characteristics of such cases of metastasis remain relatively unknown. PRESENTATION OF CASE: We present a case of isolated vaginal metastasis from rectal cancer in a 78-year-old female patient. The patient had no symptoms related to vaginal tumor. Magnetic resonance imaging (MRI) showed thickening of the middle rectum and a vaginal tumor. Biopsy from the vaginal tumor showed adenocarcinoma, similar to the rectal lesion. Low anterior resection with ileostomy, hystero-oophorectomy, and transvaginal tumor resection was performed. After nineteen months, computed tomography scan revealed multiple lung metastases and recurrent tumor in the pelvis. The patient refused chemotherapy and is alive three months after developing recurrent disease. DISCUSSION: Most cases of primary vaginal carcinoma are squamous cell carcinoma. Other histologic types such as adenocarcinoma are usually metastatic lesions. Primary lesions associated with metastatic vaginal adenocarcinoma are most often the uterus, and are very rarely from the colon or rectum. We review previous case reports of isolated vaginal metastases from colorectal cancer and discuss their symptoms, treatments, and outcomes. CONCLUSION: We should keep the vagina within the field of view of pelvic MRI, which is one of the preoperative diagnostic tools for colorectal cancer. If female patients show gynecological symptoms, gynecological examination should be recommended. Isolated vaginal metastases are an indication for surgical resection, and adjuvant chemotherapy is also recommended.
  • Tetsuhide Ito, Hiroshi Ishiguro, Hirotaka Ohara, Terumi Kamisawa, Junichi Sakagami, Naohiro Sata, Yoshifumi Takeyama, Morihisa Hirota, Hiroyuki Miyakawa, Hisato Igarashi, Lingaku Lee, Takashi Fujiyama, Masayuki Hijioka, Keijiro Ueda, Yuichi Tachibana, Yoshio Sogame, Hiroaki Yasuda, Ryusuke Kato, Keisho Kataoka, Keiko Shiratori, Masanori Sugiyama, Kazuichi Okazaki, Shigeyuki Kawa, Yusuke Tando, Yoshikazu Kinoshita, Mamoru Watanabe, Tooru Shimosegawa
    Journal of gastroenterology 51 (2) 85 - 92 2016/02 [Not refereed][Not invited]
     
    Chronic pancreatitis is considered to be an irreversible progressive chronic inflammatory disease. The etiology and pathology of chronic pancreatitis are complex; therefore, it is important to correctly understand the stage and pathology and provide appropriate treatment accordingly. The newly revised Clinical Practice Guidelines of Chronic Pancreatitis 2015 consist of four chapters, i.e., diagnosis, staging, treatment, and prognosis, and includes a total of 65 clinical questions. These guidelines have aimed at providing certain directions and clinically practical contents for the management of chronic pancreatitis, preferentially adopting clinically useful articles. These revised guidelines also refer to early chronic pancreatitis based on the Criteria for the Diagnosis of Chronic Pancreatitis 2009. They include such items as health insurance coverage of high-titer lipase preparations and extracorporeal shock wave lithotripsy, new antidiabetic drugs, and the definition of and treatment approach to pancreatic pseudocyst. The accuracy of these guidelines has been improved by examining and adopting new evidence obtained after the publication of the first edition.
  • Toru Zuiki, Yoshinori Hosoya, Yasunaru Sakuma, Masanobu Hyodo, Alan T Lefor, Naohiro Sata, Nobuhiko Nagamine, Norio Isoda, Kentaro Sugano, Yoshikazu Yasuda
    International journal of surgery case reports 19 119 - 23 2210-2612 2016 [Refereed][Not invited]
     
    INTRODUCTION: Laparoscopic gastric devascularization of the upper stomach in patients with gastric varices has rarely been reported. Perioperative clinical data were compared with patients who underwent open surgery. PRESENTATION OF CASES: From 2009 to 2012, we performed laparoscopic gastric devascularization without splenectomy for the treatment of gastric varices in eight patients. The patients included four males and four females. Peri-gastric vessels were divided using electrical coagulating devices or other devices according to the diameter of the vessels. Two patients underwent conversion to open surgery due to intraoperative bleeding. DISCUSSION: Intraoperative blood loss in patients who accomplished laparoscopic devascularization was very small (mean 76ml). However, once bleeding occurs, there is a risk of causing massive bleeding. CONCLUSION: With further improvement of laparoscopic devices, laparoscopic gastric devascularization without splenectomy must be an effective and less-invasive surgical procedure in the treatment of gastric varices.
  • Ippei Fukada, Kazuhiro Araki, Kokoro Kobayashi, Tomoko Shibayama, Shunji Takahashi, Rie Horii, Futoshi Akiyama, Takuji Iwase, Shinji Ohno, Kiyohiko Hatake, Yasuo Hozumi, Naohiro Sata, Yoshinori Ito
    PloS one 11 (9) e0162616  1932-6203 2016 [Refereed][Not invited]
     
    BACKGROUND: Pathological complete response (pCR) with neoadjuvant chemotherapy (NAC) has been regarded as a surrogate endpoint for disease-free survival (DFS) and overall survival (OS) of patients with breast cancer. No consensus regarding the definition of pCR has been established; there are several definitions according to a variety of classifications. Eradication of cancer cells in both breast and lymph nodes has been better associated with improved prognosis than in the breast alone. Even in patients diagnosed as having clinically node-negative cancer before NAC, postoperative pathological examination often shows axillary lymph node metastases. PATIENTS AND METHODS: Of the 771 patients with breast cancer who underwent NAC in the Cancer Institute Hospital between January 2000 and May 2009, 146 patients preoperatively diagnosed as having node-negative breast cancer were retrospectively evaluated. We have made the definition of clinically lymph node-negative (N0) as follows: first, ultrasonography before NAC did not show any lymphadenopathy. Second, a cytological procedure confirmed negative study for each patient when ultrasonography suggested lymphadenopathy. RESULTS: The median observation period was 79.7 months, and the median age of the subjects was 51 years. Pathological examination at the time of the surgery showed lymph node metastases (ypN+) in 46 patients (31.5%). Histological therapeutic effects revealed ypT0/is in 9 patients (6.2%) and ypTinv in 137 (93.8%). Multivariate analysis demonstrated that younger age (49>), large tumor size, NG3, and ypN+ were significant poor prognostic factors for DFS (p = 0.020, p = 0.008, P = 0.022 and p = 0.010, respectively). Moreover, ypN+ was the only significant poor prognostic factor for OS (p = 0.022). The predictive factors of ypN+ in clinically lymph node-negative breast cancer were ypTinv (p = 0.036) and the luminal type (HR+ and HER2-) (p = 0.029). CONCLUSION: The prognosis of clinically lymph node negative breast cancer depended on ypN+, which was associated with ypTinv and luminal subtype.
  • Joji Kitayama, Hironori Yamaguchi, Hironori Ishigami, Keisuke Matsuzaki, Naohiro Sata
    PloS one 11 (5) e0154542  1932-6203 2016 [Refereed][Not invited]
     
    The human peritoneal cavity contains a small number of free cells of mesenchymal cell lineage. Intraperitoneal mesenchymal cells (PMC) play supportive roles in metastasis formation on the peritoneum. In this study, we found that PMC, when co-cultuerd with human gastric cancer cells, MKN45, enhanced the proliferation of MKN45 when cultured at low, but not high, cellular density. Also, PMC suppressed apoptotic cell death of MKN45 only under low density culture conditions. Time-lapse videoanalysis clearly demonstrated that PMC randomly migrated more vigorously than did MKN45, and strongly enhanced the migration behavior of co-cultured MKN45. In fact, the majority of MKN45 migrated together in direct physical contact with PMC, and the sum of migration lengths from original position of co-cultured MKN45 for 48 hours was approximately 10 times longer than that of MKN45 cultured alone. Our data suggest that enhanced migration can increase the chance of direct contact or positional proximity among sparcely distributed MKN45, which may bring survival advantages to tumor cells. This may be one of the important mechanisms of peritoneal metastasis, since only a small number of tumor cells are considered to be disseminated in the early step of metastasis formation on the peritoneum.
  • Toshihiro Yoneyama, Sumio Ohtsuki, Kazufumi Honda, Makoto Kobayashi, Motoki Iwasaki, Yasuo Uchida, Takuji Okusaka, Shoji Nakamori, Masashi Shimahara, Takaaki Ueno, Akihiko Tsuchida, Naohiro Sata, Tatsuya Ioka, Yohichi Yasunami, Tomoo Kosuge, Takashi Kaneda, Takao Kato, Kazuhiro Yagihara, Shigeyuki Fujita, Wilber Huang, Tesshi Yamada, Masanori Tachikawa, Tetsuya Terasaki
    PloS one 11 (8) e0161009  2016 [Refereed][Not invited]
     
    Pancreatic cancer is one of the most lethal tumors, and reliable detection of early-stage pancreatic cancer and risk diseases for pancreatic cancer is essential to improve the prognosis. As 260 genes were previously reported to be upregulated in invasive ductal adenocarcinoma of pancreas (IDACP) cells, quantification of the corresponding proteins in plasma might be useful for IDACP diagnosis. Therefore, the purpose of the present study was to identify plasma biomarkers for early detection of IDACP by using two proteomics strategies: antibody-based proteomics and liquid chromatography-tandem mass spectrometry (LC-MS/MS)-based proteomics. Among the 260 genes, we focused on 130 encoded proteins with known function for which antibodies were available. Twenty-three proteins showed values of the area under the curve (AUC) of more than 0.8 in receiver operating characteristic (ROC) analysis of reverse-phase protein array (RPPA) data of IDACP patients compared with healthy controls, and these proteins were selected as biomarker candidates. We then used our high-throughput selected reaction monitoring or multiple reaction monitoring (SRM/MRM) methodology, together with an automated sample preparation system, micro LC and auto analysis system, to quantify these candidate proteins in plasma from healthy controls and IDACP patients on a large scale. The results revealed that insulin-like growth factor-binding protein (IGFBP)2 and IGFBP3 have the ability to discriminate IDACP patients at an early stage from healthy controls, and IGFBP2 appeared to be increased in risk diseases of pancreatic malignancy, such as intraductal papillary mucinous neoplasms (IPMNs). Furthermore, diagnosis of IDACP using the combination of carbohydrate antigen 19-9 (CA19-9), IGFBP2 and IGFBP3 is significantly more effective than CA19-9 alone. This suggests that IGFBP2 and IGFBP3 may serve as compensatory biomarkers for CA19-9. Early diagnosis with this marker combination may improve the prognosis of IDACP patients.
  • Toru Zuiki, Yoshinori Hosoya, Alan Kawarai Lefor, Hiroyuki Tanaka, Toshihide Komatsubara, Yuzo Miyahara, Yukihiro Sanada, Jun Ohki, Chuji Sekiguchi, Naohiro Sata
    International journal of surgery case reports 29 88 - 93 2016 [Refereed][Not invited]
     
    INTRODUCTION: Gastric volvulus is torsion of the stomach and requires immediate treatment. The optimal treatment strategy for patients with gastric volvulus is not established, because of significant variations in the cause and clinical course of this condition. PRESENTATION OF CASES: We describe our experience with six elderly patients with gastric volvulus caused by different conditions using various approaches. This includes two patients managed with endoscopic reduction, followed by endoscopic or laparoscopic gastropexy. DISCUSSION: Endoscopy is a necessary first step to determine the optimal treatment strategy, and endoscopic reduction is often effective. The indications for surgical repair of gastric volvulus depend on the patient's overall condition, and several options are available. In some elderly patients with severe comorbidities, major surgery may have an unacceptably high risk. We propose a novel treatment strategy for gastric volvulus in the elderly and a review of the literature. CONCLUSION: Early endoscopy is necessary in patients with gastric volvulus. Endoscopic or laparoscopic gastropexy may be adequate therapy in selected elderly patients.
  • Shin Saito, Yoshinori Hosoya, Kentaro Kurashina, Shiro Matsumoto, Rihito Kanamaru, Takashi Ui, Hidenori Haruta, Joji Kitayama, Alan K Lefor, Naohiro Sata
    International journal of surgery case reports 19 51 - 4 2016 [Refereed][Not invited]
     
    INTRODUCTION: Spontaneous esophageal perforation, or Boerhaave's syndrome, is a life-threating condition which usually requires emergent surgery. An upside down stomach is defined as a gastric volvulus in a huge supradiaphragmatic sac. In general, this condition can result in ischemia and perforation of the stomach. This is the first report of a patient with Boerhaave's syndrome and an upside down stomach. CASE PRESENTATION: A 79-year-old woman presented with sudden epigastric pain following hematemesis. Evaluation of the patient showed both an esophageal perforation and an upside down stomach. Surgical drainage and irrigation of the mediastinum and pleural cavities were undertaken emergently. Due to the concurrent gastric volvulus, a gastrostomy was placed to fix and decompress the stomach. The patient had an uneventful hospital course and was discharged. DISCUSSION AND CONCLUSION: Boerhaave's syndrome is a rare but severe complication caused by excessive vomiting, due to a sudden elevation in intraluminal esophageal pressure resulting in esophageal perforation. Acute gastric volvulus can result in ischemia and perforation of the stomach, but has not previously been reported with esophageal perforation. The most likely mechanism associating an upside down stomach with Boerhaave's syndrome is acute gastric outlet obstruction resulting in vomiting, and subsequent esophageal perforation. Perforation of the esophagus as well as perforation of the stomach must be considered in patients with an upside down stomach although both upside down stomach and Boerhaave's syndrome are rare clinical entities.
  • Kazuma Rifu, Koji Koinuma, Hisanaga Horie, Mitsuaki Morimoto, Yoshihiko Kono, Makiko Tahara, Yasunaru Sakuma, Yoshinori Hosoya, Joji Kitayama, Alan Kawarai Lefor, Naohiro Sata, Tsukasa Suzuki, Noriyoshi Fukushima
    International journal of surgery case reports 23 151 - 6 2016 [Refereed][Not invited]
     
    INTRODUCTION: Neuroendocrine tumors of the colon and rectum are relatively rare compared to sporadic colorectal carcinoma. There are few reports of neuroendocrine tumors of the colon and rectum in patients with ulcerative colitis. PRESENTATION OF CASE: A patient with sigmoid colon carcinoma with focal neuroendocrine features is presented. A 32-year-old man, who had been followed for ulcerative colitis for 14 years, was found to have carcinoma of the sigmoid colon on routine annual colonoscopy, and he underwent laparoscopic total colectomy. Pathologic examination showed sigmoid colon adenocarcinoma with focal neuroendocrine features. DISCUSSION: Most colorectal carcinomas associated with inflammatory bowel disease are histologically similar to the sporadic type, and tumors with neuroendocrine features are very unusual. CONCLUSION: Very rare case of sigmoid colon carcinoma with neuroendocrine features arising in a patient with UC was described.
  • Kazufumi Honda, Michimoto Kobayashi, Takuji Okusaka, Jo Ann Rinaudo, Ying Huang, Tracey Marsh, Mitsuaki Sanada, Yoshiyuki Sasajima, Shoji Nakamori, Masashi Shimahara, Takaaki Ueno, Akihiko Tsuchida, Naohiro Sata, Tatsuya Ioka, Yohichi Yasunami, Tomoo Kosuge, Nami Miura, Masahiro Kamita, Takako Sakamoto, Hirokazu Shoji, Giman Jung, Sudhir Srivastava, Tesshi Yamada
    Scientific reports 5 15921 - 15921 2015/11 [Refereed][Not invited]
     
    We recently reported that circulating apolipoprotein AII (apoAII) isoforms apoAII-ATQ/AT (C-terminal truncations of the apoAII homo-dimer) decline significantly in pancreatic cancer and thus might serve as plasma biomarkers for the early detection of this disease. We report here the development of novel enzyme-linked immunosorbent assays (ELISAs) for measurement of apoAII-ATQ/AT and their clinical applicability for early detection of pancreatic cancer. Plasma and serum concentrations of apoAII-ATQ/AT were measured in three independent cohorts, which comprised healthy control subjects and patients with pancreatic cancer and gastroenterologic diseases (n = 1156). These cohorts included 151 cases of stage I/II pancreatic cancer. ApoAII-ATQ/AT not only distinguished the early stages of pancreatic cancer from healthy controls but also identified patients at high risk for pancreatic malignancy. AUC values of apoAII-ATQ/AT to detect early stage pancreatic cancer were higher than those of CA19-9 in all independent cohorts. ApoAII-ATQ/AT is a potential biomarker for screening patients for the early stage of pancreatic cancer and identifying patients at risk for pancreatic malignancy (161 words).
  • A. Miki, Y. Sakuma, H. Sasanuma, M. Koizumi, K. Endo, N. Sata
    PANCREAS 44 (8) 1398 - 1398 0885-3177 2015/11 [Not refereed][Not invited]
  • Michihiro Saito, Hiroki Imada, Tsukasa Suzuki, Naohiro Sata, Yoshikazu Yasuda, Iruru Maetani, Noriyoshi Fukushima
    Annals of diagnostic pathology 19 (5) 347 - 52 1092-9134 2015/10 [Refereed][Not invited]
     
    Intraductal papillary mucinous neoplasms (IPMNs) of the pancreas are primary pancreatic neoplasms that can act as precursors to invasive adenocarcinoma of the pancreas. The peritumoral stroma has been increasingly recognized to play an important role in many types of tumors. Therefore, to investigate the clinicopathological significance of the peritumoral stroma in IPMNs, we examined the histological features of the peritumoral stroma in each subtype and histological grade of IPMNs. Eighty-two patients with IPMN, who underwent surgical resection, were reviewed clinicopathologically. Intraductal papillary mucinous neoplasms (86 lesions in total) were histologically subclassified into gastric (n = 51), intestinal (n = 22), pancreatobiliary (n = 11), and oncocytic (n = 2) subtypes. Peritumoral histological features between the gastric and intestinal subtypes were evaluated by each histological grade. The results showed that subepithelial edema and inflammatory cell infiltration were more commonly observed in the gastric subtype (74% and 79%, respectively) than in the intestinal subtype (12% and 25%, respectively) of low-grade IPMNs. On the other hand, mucus lakes were more commonly observed in the intestinal subtype (100%) than in the gastric subtype (0%) of high-grade IPMNs. In addition, pancreatobiliary subtype IPMNs tended to exhibit acute inflammation such as neutrophil predominance. This study showed that peritumoral histological features differed among subtypes of IPMNs from low-grade tumors. These differences suggest the possibility that each subtype of IPMNs has a distinct mechanism from an early stage of tumor progression, which is reflected in the properties of the peritumoral stroma.
  • Kazuo Inui, Yoshinori Igarashi, Atsushi Irisawa, Hirotaka Ohara, Susumu Tazuma, Yoshiki Hirooka, Naotaka Fujita, Hiroyuki Miyakawa, Naohiro Sata, Tooru Shimosegawa, Masao Tanaka, Keiko Shiratori, Masanori Sugiyama, Yoshifumi Takeyama
    Pancreas 44 (7) 1053 - 64 2015/10 [Not refereed][Not invited]
     
    OBJECTIVES: In addition to surgery, procedures for patients with pancreatolithiasis are developing; therefore, establishing practical guidelines for the management of pancreatolithiasis is required. METHODS: Three committees (the professional committee for asking clinical questions (CQs) and statements by Japanese endoscopists, the expert panel committee for rating statements by the modified Delphi method, and the evaluating committee by moderators) were organized. Eight endoscopists and a surgeon for pancreatolithiasis made the CQs and statements from a total of 694 reports of published literature by PubMed search (from 1983 to 2012). The expert panelists individually rated these clinical statements using a modified Delphi approach, in which a clinical statement receiving a median score greater than 7 on a 9-point scale from the panel was regarded as valid. RESULTS: The professional committee made 3, 7, and 10 CQs and statements for the concept and pathogenesis, diagnosis, and treatment, respectively. The expert panelists regarded them as valid after a 2-round modified Delphi approach. CONCLUSIONS: After evaluation by the moderators, the Japanese clinical guidelines for pancreatolithiasis were established. Further discussions and studies for international guidelines are needed.
  • Mitsuaki Morimoto, Yoshikazu Nakamura, Yoshikazu Yasuda, Alan T Lefor, Takashi Nagaie, Naohiro Sata, Yoshinori Hosoya, Hisanaga Horie, Koji Koinuma
    The Indian journal of surgery 77 (4) 283 - 9 0972-2068 2015/08 [Refereed][Not invited]
     
    It has been suggested that total cholesterol levels and the use of statin medications are associated with the incidence of complications after gastrointestinal surgery. The aim of this study was to determine if preoperative total cholesterol levels are associated with a higher risk of postoperative infections and mortality. A total of 2211 patients undergoing general surgical procedures between December 2006 and November 2008 at Iizuka Hospital and between January 2010 and March 2012 at Jichi Medical University Hospital were reviewed. Multiple logistic regression models were used to evaluate serum total cholesterol and other variables as predictors of postoperative nosocomial infections. Serum total cholesterol concentrations lower than 160 mg/dl were associated with an increased incidence of superficial and deep incisional surgical site infections. Serum total cholesterol levels showed a reverse J-shaped relationship with the development of organ space surgical site infection and pneumonia. There was no discernible effect of serum cholesterol levels on the postoperative mortality observed in this cohort of patients. Decreased serum albumin was one of the strongest risk factors for the development of nosocomial infection after surgery. Postoperative pneumonia was not observed in patients taking statin medications whose cholesterol levels were <200 mg/dl. Serum total cholesterol may be a valid predictor of surgical outcome. Preoperative statin use may affect the development of postoperative pneumonia in patients with total cholesterol levels below 200 mg/dl.
  • Mitsuaki Morimoto, Yasuyuki Miyakura, Alan T Lefor, Kazuya Takahashi, Hisanaga Horie, Koji Koinuma, Hiroyuki Tanaka, Homare Ito, Tetsuichiro Shimizu, Yoshihiko Kono, Naohiro Sata, Noriyoshi Fukushima, Takashi Sakatani, Yoshikazu Yasuda
    Surgery today 45 (7) 834 - 40 1436-2813 2015/07 [Refereed][Not invited]
     
    PURPOSE: We hypothesized that a reduction in the size of the lymph nodes after neoadjuvant therapy for locally advanced rectal carcinoma would be associated with decreased lymph node metastases and/or a better prognosis. METHODS: Between March 2006 and April 2012, 71 patients with primary rectal cancer received neoadjuvant chemoradiation therapy (CRT). For all lymph nodes 5 mm or larger in size, the major and minor axes were measured on CT scan images, and the product was calculated. The lymph node size was determined before and after CRT. The patients were divided into three groups based on the lymph node size before and after treatment. Group A exhibited a reduction in size of 60% or more, Group B a reduction of less than 60% and Group C had no lymph node enlargement before treatment. RESULTS: The incidence of lymph node metastases on pathological examination was 15% in Group A and 50% in Group B (p = 0.006). The five-year disease-free survival in Group A was 84% compared with 78% in Group B (log rank p = 0.34). The five-year overall survival in Group A was 92% compared with 74% in Group B (log rank p = 0.088). CONCLUSIONS: A reduction in the size of enlarged lymph nodes after neoadjuvant therapy may be a useful prognostic factor for recurrence and survival.
  • Masamichi Yokoe, Tadahiro Takada, Toshihiko Mayumi, Masahiro Yoshida, Shuji Isaji, Keita Wada, Takao Itoi, Naohiro Sata, Toshifumi Gabata, Hisato Igarashi, Keisho Kataoka, Masahiko Hirota, Masumi Kadoya, Nobuya Kitamura, Yasutoshi Kimura, Seiki Kiriyama, Kunihiro Shirai, Takayuki Hattori, Kazunori Takeda, Yoshifumi Takeyama, Morihisa Hirota, Miho Sekimoto, Satoru Shikata, Shinju Arata, Koichi Hirata
    Journal of hepato-biliary-pancreatic sciences 22 (6) 405 - 32 2015/06 
    BACKGROUND: Japanese (JPN) guidelines for the management of acute pancreatitis were published in 2006. The severity assessment criteria for acute pancreatitis were later revised by the Japanese Ministry of Health, Labour and Welfare (MHLW) in 2008, leading to their publication as the JPN Guidelines 2010. Following the 2012 revision of the Atlanta Classifications of Acute Pancreatitis, in which the classifications of regional complications of pancreatitis were revised, the development of a minimally invasive method for local complications of pancreatitis spread, and emerging evidence was gathered and revised into the JPN Guidelines. METHODS: A comprehensive evaluation was carried out on the evidence for epidemiology, diagnosis, severity, treatment, post-endoscopic retrograde cholangiopancreatography (ERCP) pancreatitis and clinical indicators, based on the concepts of the GRADE system (Grading of Recommendations Assessment, Development and Evaluation). With the graded recommendations, where the evidence was unclear, Meta-Analysis team for JPN Guidelines 2015 conducted an additional new meta-analysis, the results of which were included in the guidelines. RESULTS: Thirty-nine questions were prepared in 17 subject areas, for which 43 recommendations were made. The 17 subject areas were: Diagnosis, Diagnostic imaging, Etiology, Severity assessment, Transfer indication, Fluid therapy, Nasogastric tube, Pain control, Antibiotics prophylaxis, Protease inhibitor, Nutritional support, Intensive care, management of Biliary Pancreatitis, management of Abdominal Compartment Syndrome, Interventions for the local complications, Post-ERCP pancreatitis and Clinical Indicator (Pancreatitis Bundles 2015). Meta-analysis was conducted in the following four subject areas based on randomized controlled trials: (1) prophylactic antibiotics use; (2) prophylactic pancreatic stent placement for the prevention of post-ERCP pancreatitis; (3) prophylactic non-steroidal anti-inflammatory drugs (NSAIDs) for the prevention of post-ERCP pancreatitis; and (4) peritoneal lavage. Using the results of the meta-analysis, recommendations were graded to create useful information. In addition, a mobile application was developed, which made it possible to diagnose, assess severity and check pancreatitis bundles. CONCLUSIONS: The JPN Guidelines 2015 were prepared using the most up-to-date methods, and including the latest recommended medical treatments, and we are confident that this will make them easy for many clinicians to use, and will provide a useful tool in the decision-making process for the treatment of patients, and optimal medical support. The free mobile application and calculator for the JPN Guidelines 2015 is available via http://www.jshbps.jp/en/guideline/jpn-guideline2015.html.
  • H. Ito, Y. Miyakura, M. Morimoto, M. Koizumi, K. Koinuma, H. Horie, A. Lefor, N. Sata, Y. Yasuda
    DISEASES OF THE COLON & RECTUM 58 (5) E369 - E369 0012-3706 2015/05 [Not refereed][Not invited]
  • Atsushi Miki, Yasunaru Sakuma, Hideyuki Ohzawa, Yukihiro Sanada, Hideki Sasanuma, Alan T Lefor, Naohiro Sata, Yoshikazu Yasuda
    International surgery 100 (3) 480 - 5 0020-8868 2015/03 [Refereed][Not invited]
     
    We report a rare case of immunoglobulin G4 (IgG4)-related sclerosing cholangitis without other organ involvement. A 69-year-old-man was referred for the evaluation of jaundice. Computed tomography revealed thickening of the bile duct wall, compressing the right portal vein. Endoscopic retrograde cholangiopancreatography showed a lesion extending from the proximal confluence of the common bile duct to the left and right hepatic ducts. Intraductal ultrasonography showed a bile duct mass invading the portal vein. Hilar bile duct cancer was initially diagnosed and percutaneous transhepatic portal vein embolization was performed, preceding a planned right hepatectomy. Strictures persisted despite steroid therapy. Therefore, partial resection of the common bile duct following choledochojejunostomy was performed. Histologic examination showed diffuse and severe lymphoplasmacytic infiltration, and abundant plasma cells, which stained positive for anti-IgG4 antibody. The final diagnosis was IgG4 sclerosing cholangitis. Types 3 and 4 IgG4 sclerosing cholangitis remains a challenge to differentiate from cholangiocarcinoma. A histopathologic diagnosis obtained with a less invasive approach avoided unnecessary hepatectomy.
  • Shin Saito, Kazue Morishima, Takashi Ui, Hiroko Hoshino, Daisuke Matsubara, Shumpei Ishikawa, Hiroyuki Aburatani, Masashi Fukayama, Yoshinori Hosoya, Naohiro Sata, Alan K Lefor, Yoshikazu Yasuda, Toshiro Niki
    BMC cancer 15 82 - 82 2015/02 [Refereed][Not invited]
     
    BACKGROUND: Although advanced esophageal squamous-cell carcinoma (ESCC) is treated using a multidisciplinary approach, outcomes remain unsatisfactory. The microenvironment of cancer cells has recently been shown to strongly influence the biologic properties of malignancies. We explored the effect of supernatant from esophageal fibroblasts on the cell growth and chemo-resistance of ESCC cell lines. METHODS: We used 22 ESCC cell lines, isolated primary human esophageal fibroblasts and immortalized fibroblasts. We first examined cell proliferation induced by fibroblast supernatant. The effect of supernatant was evaluated to determine whether paracrine signaling induced by fibroblasts can influence the proliferation of cancer cells. Next, we examined the effects of adding growth factors HGF, FGF1, FGF7, and FGF10, to the culture medium of cancer cells. These growth factors are assumed to be present in the culture supernatants of fibroblasts and may exert a paracrine effect on the proliferation of cancer cells. We also examined the intrinsic role of HGF/MET and FGFs/FGFR in ESCC proliferation. In addition, we examined the inhibitory effect of lapatinib on ESCC cell lines and studied whether the fibroblast supernatants affect the inhibitory effect of lapatinib on ESCC cell proliferation. Finally, we tested whether the FGFR inhibitor PD-173074 could eliminate the rescue effect against lapatinib that was induced by fibroblast supernatants. RESULTS: The addition of fibroblast supernatant induces cell proliferation in the majority of cell lines tested. The results of experiments to evaluate the effects of adding growth factors and kinase inhibitors suggests that the stimulating effect of fibroblasts was attributable in part to HGF/MET or FGF/FGFR. The results also indicate diversity in the degree of dependence on HGF/MET and FGF/FGFR among the cell lines. Though lapanitib at 1 μM inhibits cell proliferation by more than 50% in the majority of the ESCC cell lines, fibroblast supernatant can rescue the growth inhibition of ESCC cells. However, the rescue effect is abrogated by co-treatment with FGFR inhibitor. CONCLUSION: These results demonstrate that cell growth of ESCC depends on diverse receptor tyrosine kinase signaling, in both cell-autonomous and cell-non-autonomous manners. The combined inhibition of these signals may hold promise for the treatment of ESCC.
  • Hideki Ishioka, Naohiro Sata, Yasunao Ishiguro, Alan Lefor, Yoshikazu Yasuda
    JOP : Journal of the pancreas 16 (1) 70 - 3 2015/01 
    CONTEXT: Insulinomas, which are generally smaller than 2 cm, may be difficult to detect by routine imaging modalities including abdominal ultrasonography, computed tomography, and magnetic resonance imaging. Although preoperative detection of insulinomas is essential for operative planning, it is often challenging due to their small size. While arterial stimulation and venous sampling has been used in patients with insulinomas it has been largely supplanted by early-phase thin-slice computed tomography. CASE REPORT: We report three patients with insulinomas, which were not detected by routine computed tomography scan, but were successfully imaged using early-phase thin-slice computed tomography. Enucleation was performed in all patients based on preoperative imaging. All three patients had an unremarkable postoperative course. CONCLUSION: Early-phase thin-slice computed tomography is recommended for the preoperative identification of insulinomas. This non-invasive imaging technique should be considered before performing arterial stimulation and venous sampling.
  • Takashi Ui, Hiroyuki Shibusawa, Hidenori Tsukui, Kazuya Sakuma, Shuhei Takahashi, Alan K Lefor, Yoshinori Hosoya, Naohiro Sata, Yoshikazu Yasuda
    International journal of surgery case reports 12 87 - 9 2210-2612 2015 [Refereed][Not invited]
     
    INTRODUCTION: Gastric outlet obstruction is characterized by the retention of gastric contents. Removal of gastric contents is an important part of the treatment strategy. The use of a nasogastric tube alone can result in inadequate removal of gastric contents. We treated a patient with advanced gastric cancer and gastric outlet obstruction with pancrelipase to aid in the removal of gastric contents. PRESENTATION OF CASE: The patient is an 81-year-old man with a Type 3 gastric cancer nearly circumferentially involving the antrum, resulting in gastric outlet obstruction. A nasogastric tube was placed for four days, but drainage of gastric contents was inadequate. Pancrelipase was then given orally for four days, and gastric contents were evacuated. The patient underwent distal gastrectomy with Roux-en-Y reconstruction and was discharged from the hospital on postoperative day 14. DISCUSSION: This report suggests that pancrelipase may be beneficial in the treatment of patients with gastric outlet obstruction. CONCLUSION: Pancrelipase allowed gastric contents to be evacuated in a short period of time in a patient with gastric outlet obstruction.
  • Masanobu Taguchi, Naohiro Sata, Yuji Kaneda, Masaru Koizumi, Masanobu Hyodo, Alan Kawarai Lefor, Hirotoshi Kawata, Yoshikazu Yasuda
    International journal of surgery case reports 8C 62 - 7 2210-2612 2015 [Refereed][Not invited]
     
    INTRODUCTION: Radical resection of bile duct carcinoma may require resection of hepatic arteries. Preoperative segmental embolization of the hepatic artery for resection of hilar cholangiocarcinoma has been reported. We report a patient with bile duct carcinoma infiltrating the proper hepatic artery. PRESENTATION OF CASE: A 66-year old male with jaundice was diagnosed with mid-distal bile duct carcinoma. A replaced left hepatic artery originated from the left gastric artery. Pylorus-preserving pancreaticoduodenectomy (PPPD) with combined resection of hepatic artery was planned. To promote the development of collateral blood flow after excision of the hepatic artery, preoperative segmental embolization of the proper hepatic artery was performed. The patient underwent PPPD with concurrent resection of the common hepatic, right hepatic, and middle hepatic arteries without arterial reconstruction. He received adjuvant chemotherapy with gemcitabine for six months and is alive three years after surgery without tumor recurrence. DISCUSSION: The growth of collateral vessels after selective embolization of the proper hepatic artery has been used for hilar lesions and bile duct lesions. Resection of the hepatic artery without the need for complex arterial reconstruction, allowing a radical resection, may have contributed to this patient's relatively unremarkable recovery and long-term survival. Retroperitoneal mobilization of the pancreatic head and duodenum must be limited as important collaterals may originate in that area. CONCLUSION: Preoperative segmental embolization of the hepatic artery before PPPD for a patient with a replaced left hepatic artery encouraged the growth of collateral blood supply, allowing radical resection including the vessels and obviated the need for arterial reconstruction.
  • Masanobu Taguchi, Yasunaru Sakuma, Hideki Sasanuma, Naohiro Sata, Alan Kawarai Lefor, Takahiro Sasaki, Akira Tanaka, Yoshikazu Yasuda
    International journal of surgery case reports 10 20 - 4 2210-2612 2015 [Refereed][Not invited]
     
    INTRODUCTION: We report a patient with a rapidly progressing recurrence of hepatocellular carcinoma (HCC) with a portal vein tumor thrombus after radiofrequency ablation of the original lesion, then treated with transcatheter arterial infusion. Radical hepatic resection demonstrated a complete pathological response. PRESENTATION OF CASE: A 60-year old male with alcoholic cirrhosis and gastric varices was diagnosed with HCC measuring 12mm in segment 8. He underwent laparoscopic radiofrequency ablation, but recurred three months later. The lesion progressed rapidly and the right portal vein was occluded. He then underwent transcatheter arterial infusion with miriplatin and iodized oil, which was effective in reducing the size of the main lesion and portal vein tumor thrombus. Right anterior sectionectomy was then performed. Pathologically, there were no viable HCC cells in either the main lesion or the portal vein thrombus. He is alive two years and nine months after surgery without recurrence. DISCUSSION: A rapidly progressing HCC recurrence with portal vein tumor thrombus is usually associated with a poor prognosis. No effective treatments have been reported in this situation except hepatic resection. In this patient the tumor was effectively reduced after three courses of transarterial miriplatin and subsequent radical hepatic resection. This is the first report to achieve a complete pathological response for such an aggressive recurrence after initial radiofrequency ablation. CONCLUSION: This strategy may result in long-term survival of patients with rapidly progressing recurrent HCC with portal vein thrombus, and further study is warranted.
  • Masaru Koizumi, Yoshinori Hosoya, Katsuya Dezaki, Toshihiko Yada, Hiroshi Hosoda, Kenji Kangawa, Hideo Nagai, Alan T Lefor, Naohiro Sata, Yoshikazu Yasuda
    Surgery today 44 (11) 2131 - 7 0941-1291 2014/11 [Refereed][Not invited]
     
    PURPOSE: Ghrelin may lead to weight gain by appetite stimulation. This prospective study investigated the association between weight loss and the ghrelin levels in patients after gastrectomy. METHODS: Thirty-three males and eight females were enrolled in the study. The average age was 66 years. Measurements of the serum ghrelin level and an appetite questionnaire were performed preoperatively and at one, three, six and 12 months postoperatively. RESULTS: The preoperative serum total ghrelin level was 51.6 ± 31.9 (fmol/ml ± SD), and that at one, three, six and 12 months postoperatively was 16.9 ± 9.0, 21.2 ± 16.0, 28.0 ± 19.1 and 29.6 ± 20.6 (fmol/ml ± SD), respectively. The appetite score was 2.02 ± 1.09 points at 1 month, and increased significantly to 2.61 ± 1.00 by 12 months. CONCLUSIONS: The ghrelin levels were reduced after gastrectomy and did not recover by 12 months postoperatively. Further studies are needed to evaluate these results as the basis of a therapeutic trial.
  • Yoshiyuki Meguro, Noriyoshi Fukushima, Masaru Koizumi, Naoya Kasahara, Masanobu Hydo, Kazue Morishima, Naohiro Sata, Alan T Lefor, Yoshikazu Yasuda
    Pathology international 64 (9) 465 - 71 1320-5463 2014/09 [Refereed][Not invited]
     
    A 54-year-old Japanese woman was referred with a gallbladder tumor. Based on the results of the computed tomography scan, endoscopic retrograde cholangiopancreatography, and magnetic resonance cholangiopancreatography, a mucin-producing neoplasm of the gallbladder associated with pancreaticobiliary maljunction was diagnosed. Extended cholecystectomy, extrahepatic bile duct resection, and choledochojejunostomy were performed, and she remains free of recurrence 24 months after resection. Histopathological examination revealed that the papillary component of the lesion was an intracystic papillary neoplasm with diverse characteristics of pancreaticobiliary epithelium and intestinal epithelium including mucin. In this component, most of the papillary lesion was a high-grade intraepithelial neoplasm, but also showed slight invasion into the muscular layer. The nodular component consisted of both poorly differentiated biliary type adenocarcinoma and large cell neuroendocrine carcinoma. We report a rare case of a mixed adenoneuroendocrine carcinoma arising from an intracystic papillary neoplasm associated with pancreaticobiliary maljunction. As for the histogenesis of this tumor, based on the histopathologic appearance, transdifferentiation from poorly differentiated biliary type adenocarcinoma to large cell neuroendocrine carcinoma is considered the most possible histogenesis of this tumor.
  • Mikio Shiozawa, Shigeru Kobayashi, Yugo Sato, Hiroyuki Maeshima, Yasuo Hozumi, Alan T Lefor, Katsumi Kurihara, Naohiro Sata, Yoshikazu Yasuda
    Breast cancer (Tokyo, Japan) 21 (4) 394 - 401 1340-6868 2014/07 [Refereed][Not invited]
     
    BACKGROUND: The sentinel lymph node (SLN) biopsy technique using superparamagnetic iron oxide (SPIO) as a tracer instead of radioisotopes has been described. To further advance this technique, we evaluated preoperative SPIO-MR sentinel lymphography to facilitate the accurate identification of the lymphatic pathways and primary SLN. METHODS: A prospective study was performed in ten patients with breast cancer and clinically negative axillary lymph nodes. None of the patients received preoperative chemotherapy. After 1.6 ml of SPIO (ferucarbotran) was injected in the subareolar breast tissue, sentinel axillary lymph nodes were detected by MRI in T2*-weighted gradient echo images and resected using the serial SPIO-SLN biopsy procedure with a handheld magnetometer. RESULTS: In one patient, gadolinium-enhanced MR imaging was performed at the same time as SPIO-MR lymphography, and this patient was excluded from further analysis. In all patients (9/9) SLNs were detected by SPIO-MR sentinel lymphography and successfully identified at surgery. The number of SLNs detected by lymphography (mean 2.7) significantly correlated with SLNs identified at surgery (mean 2.2). One patient had nodal metastases. In one patient, skin color changed to brown at the injection site and resolved spontaneously. There were no severe reactions to the procedure or complications in any patient. CONCLUSIONS: This is the first study to evaluate SPIO both as a contrast material in MR sentinel lymphography and as a tracer in SLN biopsy using an integrated method. The acquired three-dimensional imaging demonstrated excellent image quality and usefulness to identify SLN in conjunction with SLN biopsy.
  • Shin Saito, Kazue Morishima, Takashi Ui, Daisuke Matsubara, Tomoko Tamura, Sachiko Oguni, Yoshinori Hosoya, Naohiro Sata, Alan T Lefor, Yoshikazu Yasuda, Toshiro Niki
    Oncology reports 32 (1) 348 - 54 1021-335X 2014/07 [Refereed][Not invited]
     
    The growth, invasiveness and metastasis of human cancers are determined not only by cancer cells, but also by their microenvironment. Activated stromal fibroblasts promote tumor progression by secreting growth factors. In the present study, we focused on interrelations between cancer and fibroblasts, the main component of tumor stroma. We retrospectively analyzed the relations of mortality to clinical, pathological, and α-smooth muscle actin (α-SMA) characteristics in 97 consecutive patients with esophageal squamous cell carcinoma (ESCC). In vitro, we used TE-11, KYSE150 and KYSE220 ESCC cell lines and isolated esophageal stromal fibroblasts, some of which were immortalized. Migration assays were conducted to assess the effects of fibroblasts on cancer-cell migration and 3-dimensional organotypic cultures. In vivo, TE-11 and KYSE220 cells plus immortalized fibroblasts were co-transplanted subcutaneously in Nod/Scid mice to assess the effects of fibroblasts on tumorigenicity. Clinicopathologically, the α-SMA expression of cancer stroma was correlated with venous invasion (p<0.01), nodal involvement (p=0.02), recurrence (p=0.01), and was a predictor of survival in patients with stage I and II ESCC (p=0.04). In vitro, the presence of fibroblasts strongly promoted the migration of TE-11, KYSE150 and KYSE220 cells. On organotypic culture, stromal invasion was observed only in the presence of immortalized fibroblasts. In vivo, tumors developed or grew in a fibroblast‑dependent manner after implantation. Our findings provide evidence that stromal fibroblasts and tumor cells interact to promote tumor progression in ESCC. In patients with earlier stage ESCC, α-SMA may be a predictor of mortality. Inhibition of paracrine systems associated with tumor fibroblasts may slow or reverse tumor progression, potentially leading to the development of new targeted therapies.
  • Sanada Y, Yamada N, Taguchi M, Morishima K, Kasahara N, Kaneda Y, Miki A, Ishiguro Y, Kurogochi A, Endo K, Koizumi M, Sasanuma H, Fujiwara T, Sakuma Y, Shimizu A, Hyodo M, Sata N, Yasuda Y
    International surgery 99 (4) 426 - 431 0020-8868 2014/07 [Refereed][Not invited]
  • Kazuhiro Endo, Takahiro Sasaki, Naohiro Sata, Shuji Hishikawa, Hideharu Sugimoto, Alan T Lefor, Yoshikazu Yasuda
    Surgical laparoscopy, endoscopy & percutaneous techniques 24 (3) 221 - 5 1530-4515 2014/06 [Refereed][Not invited]
     
    BACKGROUND: The goal of this study is to examine changes in pancreatic perfusion due to pneumoperitoneum using perfusion CT in vivo. METHODS: Three pigs were studied. Under general anesthesia, pneumoperitoneum was induced to 16 mm Hg. Perfusion CT scans were acquired at a rate of 1 image per 2 seconds for 60 seconds. Scans were repeated 5 days later without pneumoperitoneum using the same protocol, in the same animals. The time density curve, color map, peak enhancement, time to peak, blood flow, blood volume, and permeability were evaluated. RESULTS: In the presence of pneumoperitoneum, peak enhancement in radiodensity was decreased and time to peak was increased, and both blood flow and blood volume decreased. However, there was no consistent change in permeability observed. CONCLUSION: This study demonstrates that pneumoperitoneum quantitatively results in decreased blood flow and blood volume to the pancreas in an in vivo animal model.
  • Toru Zuiki, Yoshiyuki Meguro, Hidetoshi Kumano, Koji Koinuma, Yasuyuki Miyakura, Hisanaga Horie, Alan T Lefor, Naohiro Sata, Yoshikazu Yasuda
    Case reports in gastroenterology 8 (2) 162 - 8 2014/05 [Refereed][Not invited]
     
    A 41-year-old woman was admitted with upper abdominal pain, vomiting and fever. Abdominal CT scan showed a colo-duodenal fistula with inflammatory thickening of the transverse colon. The patient's general health was poor because of hypoalbuminemia and coagulopathy. Endoscopy showed a fistula at the lower duodenal angle and the stomach was filled with refluxed stool. Ileostomy and percutaneous endoscopic gastrostomy were performed at that time and a double lumen gastro-jejunostomy inserted through the gastrostomy to allow both gastric drainage and distal enteral feeding. Nutrition support was gradually converted from parenteral to enteral feeding. Colonoscopy showed stenosis of the transverse colon with a colo-colonic fistula near the stenosis. Two months later, right hemi-colectomy and closure of the colo-duodenal fistula were performed. The resected specimen showed stenosis and a fistula in the transverse colon due to Crohn's disease. The colo-colonic fistula was present and the colo-duodenal fistula had almost closed due to fibrosis. The postoperative course was uneventful and the patient was discharged after administration of infliximab. Use of a double lumen gastro-jejunostomy tube was effective in improving the patient's general condition. This therapeutic strategy allowed the safe conduct of major resection in a high-risk patient.
  • Naohiro Sata, Masaru Koizumi, Yuji Kaneda, Yasunao Ishiguro, Akira Kurogochi, Kazuhiro Endo, Hideki Sasanuma, Yasunaru Sakuma, Alan Lefor, Yoshikazu Yasuda
    Journal of gastrointestinal surgery : official journal of the Society for Surgery of the Alimentary Tract 18 (4) 858 - 64 1091-255X 2014/04 [Refereed][Not invited]
     
    Rational treatment for neoplasms of the duodenal papilla (NDPs) is still controversial, especially for early stage lesions. Total papillectomies are indicated in patients expected to have adenomas, adenocarcinoma in an adenoma, or mucosal adenocarcinomas with no lymph node metastases. However, the preoperative pathological evaluation of NDPs is still challenging and often inaccurate, mainly because of the complicated anatomical structures involved and the possibility of an adenocarcinoma in an adenoma. Herein, we introduce a new method of total papillectomy, the extraduodenal papillectomy (ExDP). In this method, papillectomy is undertaken from outside of the duodenum, instead of resection from the inside through a wide incision of the duodenal wall as is done in conventional transduodenal papillectomy (TDP). The advantages of ExDP are precise and deeper cutting of the sphincter and shorter exploration time of the tumor compared to conventional TDP. We demonstrate three representative patients, all of whom had an uneventful postoperative course. One of them subsequently underwent a pylorus preserving pancreatoduodenectomy after detailed postoperative pathological evaluation. Including that patient, no recurrence has occurred with 37-46 months of follow-up. In conclusion, ExDP is regarded as a "total biopsy" for early stage borderline lesions and a feasible, less demanding alternative method for the treatment of NDPs.
  • M. Koizumi, N. Sata, Y. Kaneda, K. Endo, H. Sasanuma, Y. Sakuma, M. Ota, A. T. Lefor, Y. Yasuda
    Hernia 18 (6) 845 - 848 1248-9204 2014 [Refereed][Not invited]
     
    Purpose: This retrospective study evaluates the clinical course and outcomes of patients who underwent surgery for strangulated hernias. Methods: Among 520 groin hernias from 2001 to 2012, 51 inguinal and 42 femoral hernias were strangulated and operated emergently at a tertiary referral center. Perioperative factors, patient profiles, and time interval to surgery (Ttotal = time from onset to surgery, T1 = time from onset to initial evaluation, T2 = time from the first hospital to the tertiary center, T3 = time from admission at the tertiary center to surgery, Ttotal = T1 + T2 + T3) were analyzed in patients with strangulation, then compared between two groups, the bowel resection (BR) group and the non-bowel resection (NBR) group. Results: T1, T2 and Ttotal in the bowel resection group were significantly longer than those in the non-bowel resection group (P <  0.05). Patients who presented initially to the tertiary center (T2 = 0) had a significantly lower resection rate than patients transported from other hospitals (24 vs. 44 %, P = 0.048). There was no significant difference in morbidity between the BR and NBR groups (35 vs. 24 %, P = 0.231). Conclusions: The elapsed time from onset to surgery, especially T1 and T2, is the most important prognostic factor in patients with strangulated groin hernias. Early diagnosis and transportation are essential for good outcomes.
  • Naoya Kasahara, Takumi Teratani, Junshi Doi, Yuki Iijima, Masashi Maeda, Shinji Uemoto, Yasuhiro Fujimoto, Naohiro Sata, Yoshikazu Yasuda, Eiji Kobayashi
    Cell medicine 5 (2-3) 75 - 81 2013/11 
    Pancreatic islet transplantation has received widespread attention as a promising treatment for type 1 diabetes. However, islets for transplantation are subject to damage from a number of sources, including ischemic injury during removal and delivery of the donor pancreas, enzymatic digestion during islet isolation, and reperfusion injury after transplantation in the recipient. Here we found that protein fractions secreted by mesenchymal stem cells (MSCs) were capable of activating preserved islets. A conditioned medium from the supernatant obtained by culturing adipose tissue MSCs (derived from wild-type Lewis rats) was prepared for 2 days in serum-free medium. Luc-Tg rat islets to which an organ preservation solution was added were then incubated at 4°C with fractions of various molecular weights prepared from the conditioned medium. Under the treatment with some of the fractions, by 4 days the relative luminescence intensities (representative of the ATP levels of the cold-preserved islets) had increased to over 150% of their initial values. Our novel system may be able to restore isolated islets to the condition they were in before transport, culture, and transplantation.
  • A. Miki, Y. Sakuma, H. Sasanuma, Y. Kaneda, N. Sata, Y. Yasuda
    PANCREAS 42 (8) 1368 - 1368 0885-3177 2013/11 [Not refereed][Not invited]
  • Toru Zuiki, Yoshinori Hosoya, Yuji Kaneda, Kentaro Kurashina, Shin Saito, Takashi Ui, Hidenori Haruta, Masanobu Hyodo, Naohiro Sata, Alan T Lefor, Yoshikazu Yasuda
    Surgical endoscopy 27 (10) 3683 - 9 0930-2794 2013/10 [Refereed][Not invited]
     
    BACKGROUND: The double-stapling technique (DST) for esophagojejunostomy using the transorally inserted anvil (OrVil; Covidien Japan, Tokyo, Japan) is one of the reconstruction methods used after laparoscopy-assisted total gastrectomy (LATG). This technique has potential advantages in terms of less invasive surgery without the need to create a complicated intraabdominal anastomosis. METHODS: From 2008 to 2011, 262 patients with gastric cancer underwent total gastrectomy and reconstruction with a Roux-en-Y anastomosis, and 52 patients underwent LATG with DST. A retrospective analysis then was performed comparing the patients who experienced postoperative stenosis after LATG-DST (positive group) and the patients who did not (negative group). A comparative analysis was performed among patients comparing conventional open total gastrectomy and LATG, and multivariate analysis was performed to evaluate risk factors for the development of anastomotic stenosis. RESULTS: A minor leak was found in 1 patient (1.9 %), and 11 patients experienced anastomotic stenosis (21 %) after LATG with DST. Among the patients with anastomotic stenosis, three (3/4, 75 %) anastomoses were performed with the 21-mm end-to-end anastomosis (EEA) stapler, and eight anastomoses were performed (8/47, 17 %) with the 25-mm EEA stapler. The median interval to the diagnosis of anastomotic stenosis was 43 days after surgery. The patients with stenosis needed endoscopic balloon dilation an average of four times, and the rate of perforation after dilation was 13 %. The clinical and operative characteristics did not differ between the two groups. Anastomotic stenosis after open total gastrectomy occurred in two cases (0.98 %). Multivariate analysis showed that the size of the EEA stapler and the use of DST were risk factors for anastomotic stenosis. CONCLUSION: Esophagojejunostomy using DST with OrVil is useful in performing a minimally invasive procedure but carries a high risk of anastomotic stenosis.
  • Mikio Shiozawa, Alan T Lefor, Yasuo Hozumi, Katsumi Kurihara, Naohiro Sata, Yoshikazu Yasuda, Moriaki Kusakabe
    Breast cancer (Tokyo, Japan) 20 (3) 223 - 9 1340-6868 2013/07 [Refereed][Not invited]
     
    BACKGROUND: Some hospitals lack facilities for radioisotopes in sentinel node biopsy. A novel method is used with a superparamagnetic tracer and a magnetometer instead of a radioisotope. METHODS: Thirty patients were included in the study after obtaining IRB approval. Superparamagnetic iron oxide and patent blue dye were injected in the subareolar breast tissue. Following a few minutes of massage to promote migration of the iron tracer and blue dye throughout the lymphatic vessels, the axillary lymph nodes were detected transdermally using a handheld magnetometer and followed by standard axillary dissection in all patients. RESULTS: Of 30 patients evaluated, sentinel lymph nodes were identified in 90% (27/30) using both blue dye and magnetic tracer. Sentinel lymph nodes were identified using the magnetic method in 23/30 (77%) and blue dye in 24/30 (80%). There was one false-negative sentinel node, resulting in an overall sensitivity of 6/7 (86%). CONCLUSIONS: This is the first study to use a magnetic tracer to identify sentinel lymph nodes in patients with breast cancer. This new technique may alter the role of radioisotopes with further refinement and experience.
  • Yoshinori Hosoya, Miho Matsumura, Seiji Madoiwa, Toru Zuiki, Shiro Matsumoto, Shin Nunomiya, Alan Lefor, Naohiro Sata, Yoshikazu Yasuda
    Surgery today 43 (6) 670 - 4 0941-1291 2013/06 [Refereed][Not invited]
     
    We report a case of acquired hemophilia A (AHA) after esophageal resection. The patient was an 80-year-old woman whose preoperative activated partial-thromboplastin time (APTT) was well within the normal range, at 34.9 s. She underwent thoracic esophagectomy and gastric pull-up for superficial esophageal cancer (operative time, 315 min; intraoperative blood loss, 245 ml). Intrathoracic and subcutaneous bleeding occurred spontaneously on postoperative day (POD) 39. The APTT was prolonged, at 140 s, and factor VIII inhibitor was 36 Bethesda U/ml. Treatment with recombinant activated factor VII, prednisolone, and cyclophosphamide resulted in remission within 2 months. This case supports an association between surgery and the triggering of factor VIII inhibitors. The diagnosis of AHA requires clinical acumen and must be considered in any patient with bleeding and a prolonged APTT.
  • Otohiro Katsube, Shin Saito, Yoshinori Hosoya, Toshihide Komatsubara, Takashi Ui, Kentaro Kurashina, Hidenori Haruta, Toru Zuiki, Takehiko Yamaguchi, Naohiro Sata, Yoshikazu Yasuda
    Clinical journal of gastroenterology 6 (3) 207 - 10 1865-7257 2013/06 [Refereed][Not invited]
     
    We report on a 53-year-old male with esophageal cancer. He had no evidence of distant metastasis, and received a subtotal esophagectomy. Histopathologically, the tumors were contiguous with Barrett's epithelium. Undifferentiated carcinoma components existed independently of differentiated adenocarcinoma components. Undifferentiated carcinoma was present proximal to the esophagogastric junction. Both tumors had invaded the submucosa and were associated with a prominent lymphoid stroma. Metastasis from undifferentiated carcinoma was found in the paraesophageal lymph nodes. Immunohistochemically, both components were negative for 34bE12 and positive for CAM5.2 and showed nearly identical staining patterns for p53, indicating that the tumors were derived from Barrett's epithelium. Because the undifferentiated carcinoma did not express CK20 or carcinoembryonic antigen, the properties of adenocarcinoma had apparently been lost during the process of tumor cell progression. This is the first report of undifferentiated carcinoma associated with Barrett's esophagus with adenocarcinoma.
  • Mikio Shiozawa, Yasuyuki Miyakura, Makiko Tahara, Kazue Morishima, Hidetoshi Kumano, Koji Koinuma, Hisanaga Horie, Alan T Lefor, Naohiro Sata, Yoshikazu Yasuda, Kenji Gonda, Seiichi Takenoshita, Akihiko Tamura, Noriyoshi Fukushima, Kokichi Sugano
    Journal of gastroenterology 48 (6) 770 - 6 0944-1174 2013/06 [Refereed][Not invited]
     
    BACKGROUND: Lynch syndrome, also referred to as hereditary nonpolyposis colorectal cancer, is the most common form of hereditary colorectal cancer, and is associated with a high incidence of multiple primary neoplasms in various organs. METHODS: A 79-year-old woman (patient 1) diagnosed with ascending colon cancer had a history of previous carcinomas of the uterus, stomach, uroepithelial tract, and colon. One year later, she developed a brain tumor (glioblastoma). A 54-year-old female (patient 2) was diagnosed with endometrial cancer and sigmoid colon cancer. Both patients underwent genetic evaluations independently. RESULTS: No mutations were found in an exon-by-exon analysis of genomic DNA by polymerase chain reaction (PCR) and reverse transcription (RT)-PCR. However, multiplex ligation-dependent probe amplification (MLPA) identified genomic duplication spanning from exon 7 to exon 14 of the MSH2 gene in both patients. Due to the presence of this characteristic gene duplication, their pedigrees were investigated further, and these showed that they are paternal half-sisters, consistent with paternal inheritance. CONCLUSION: Large genomic duplication from intron 6 through intron 14 in MSH2 is a very rare cause of Lynch syndrome and is difficult to identify with conventional methods. MLPA may be an alternative approach for detecting large-scale genomic rearrangements.
  • Shiro Matsumoto, Naohiro Sata, Masaru Koizumi, Alan Lefor, Yoshikazu Yasuda
    PANCREATOLOGY 13 (3) 320 - 323 1424-3903 2013/05 [Refereed][Not invited]
     
    We present three patients with T2 acinar cell carcinomas (ACC) (two of which were small) and discuss their clinical and pathological features. Case 1: A 34 year-old woman had a 2.6 cm iso- or hyperdense tumor. Enucleation was performed but final diagnosis was ACC and a pylorus preserving pancreaticoduodenectomy was performed. Case 2: A 35 year-old woman was found to have a 4.5 cm hypervascular tumor in the tail of the pancreas. Distal pancreatectomy was performed. Case 3: A 61 year-old man suffered from acute pancreatitis and was found to have an encapsulated 2.5 cm hypervascular tumor in the head of pancreas. Pylorus-preserving pancreaticoduodenectomy was performed. These three patients with T2 ACCs had common characteristics including well-demarcated exophytic tumors with slow and limited progress, distinctively different from large ACCs and pancreatic ductal adenocarcinomas. ACCs are important in the differential diagnosis of homogeneously or heterogeneously enhancing small pancreatic tumors. Copyright (c) 2013, IAP and EPC. Published by Elsevier India, a division of Reed Elsevier India Pvt. Ltd. All rights reserved.
  • K. Endo, T. Sasaki, N. Sata, S. Hishikawa, H. Sugimoto, Y. Yasuda
    PANCREAS 41 (8) 1358 - 1358 0885-3177 2012/11 [Not refereed][Not invited]
  • A. Miki, N. Sata, Y. Sakuma, M. Taguchi, N. Kasahara, K. Morishima, Y. Kaneda, K. Endo, M. Koizumi, H. Sasanuma, A. Shimizu, M. Hyodo, A. T. Lefor, Y. Yasuda
    PANCREAS 41 (8) 1386 - 1386 0885-3177 2012/11 [Not refereed][Not invited]
  • Masaru Koizumi, Naohiro Sata, Masanobu Taguchi, Naoya Kasahara, Kazue Morishima, Yuji Kaneda, Atsushi Miki, Kunihiko Shimura, Hideki Sasanuma, Takehito Fujiwara, Makoto Ota, Atsushi Shimizu, Masanobu Hyodo, Alan T. Lefor, Yoshikazu Yasuda
    JOURNAL OF SURGICAL EDUCATION 69 (5) 605 - 610 1931-7204 2012/09 [Refereed][Not invited]
     
    OBJECTIVE: The Lichtenstein inguinal hernia repair is commonly performed and suitable for teaching basic surgical skills. The objective of this study is to evaluate the feasibility of this procedure for surgical training, particularly in regard to patient outcomes. DESIGN: Retrospective case review after introduction of an integrated teaching program. SETTING: University teaching hospital. PARTICIPANTS: The Lichtenstein inguinal hernia repair is the standard procedure for adult primary unilateral inguinal hernia since 2003 at Jichi Medical University. We introduced an integrated teaching system of lectures, skill training, and videos to teach the skills for Lichtenstein inguinal hernia repair to residents and junior faculty in 2003. Cases were retrospectively divided into 4 groups. based on the experience of the operating surgeon; junior residents (PGY 1-2, group A), senior residents (PGY 3-5, group B), junior faculty (PGY 6-10, group C), and senior faculty (PGY 11 or more, group D). Background, perioperative factors, and outcomes were evaluated among the groups. RESULTS: A total of 246 elective inguinal hernia repairs (group A: 136, group B: 49, group C: 42, group D: 19) were performed. There was a significant difference in the frequeney of concomitant diseases (p = 0.012) and anticoagulant therapy (p = 0.031). Average operating time was 80.7 +/- 24.9, 72.6 +/- 20.8, 63.5 +/- 22.0, and 54.7 +/- 27.9 (min +/- SD) in groups A, B, C, and D, respectively, with a significant difference between groups A and D (p < 0.001). No significant differences were observed in estimated blood loss (p = 0.216) or morbidity (p = 0.294). CONCLUSIONS: The Lichtenstein inguinal hernia repair can be safely performed by residents and junior faculty with the appropriate supervision of senior faculty without any disadvantage to patients. This integrated teaching program for Lichtenstein inguinal hernia repair is effective and feasible for training residents and junior faculty. (J Surg 69:605-610. (C) 2012 Association of Program Directors in Surgery. Published by Elsevier Inc. All rights reserved.)
  • Atsushi Miki, Yasuyuki Miyakura, Yasunaru Sakuma, Hidetoshi Kumano, Hisanaga Horie, Naohiro Sata, Alan T Lefor, Yoshikazu Yasuda
    The American surgeon 78 (9) E425-6 - E426 0003-1348 2012/09 [Refereed][Not invited]
  • Shin Saito, Yoshinori Hosoya, Kazue Morishima, Takashi Ui, Hidenori Haruta, Kentaro Kurashina, Yoshiyuki Meguro, Toru Zuiki, Naohiro Sata, Hirofumi Fujii, Daisuke Matsubara, Toshiro Niki, Alan T Lefor, Yoshikazu Yasuda
    Journal of digestive diseases 13 (8) 407 - 13 1751-2972 2012/08 [Refereed][Not invited]
     
    OBJECTIVE: Adenosquamous carcinoma originating in the stomach is an unusual neoplasm with few existing histological studies. This study was aimed to gain insight into the histogenetic and clinicopathological characteristics of gastric cancer with squamous cell carcinoma (SCC) components. METHODS: From January 2001 to June 2010 a total of 1735 patients underwent a resection of gastric cancer. Histopathologically, eight patients had adenocarcinoma containing SCC components, in which the proportion of SCC components was above 25% of the total tumor mass in four patients. The immunohistochemical and clinicopathological characteristics of these eight patients were analyzed. RESULTS: The median survival duration was 22 months. Adenocarcinoma was present at the superficial layer of all tumors and SCC was primarily present at sites with deep invasion. Immunohistochemically, adenocarcinoma components were positive for cytokeratin (CK) 8/18/19 and CK7 in all cases. SCC components were positive for carcinoembryonic antigen and CK7 in more than 60% of patients. Expression patterns of p53 product were identical in both components. SCC components were positive for 34βE12 and adenocarcinoma components were negative for 34βE12 in all patients. CONCLUSIONS: SCC components are derived from squamous metaplasia in a pre-existing adenocarcinoma. A gastric adenocarcinoma with SCC components is associated with various patterns of metastasis and both SCC and adenocarcinoma components have the potential for metastasis. Gastric cancer with SCC components is a clinically aggressive tumor.
  • Yasuyuki Miyakura, Ai Sadatomo, Makoto Ohta, Alan T Lefor, Naohiro Sata, Naoyuki Nishimura, Takashi Sakatani, Yoshikazu Yasuda
    Surgery today 42 (7) 693 - 6 0941-1291 2012/07 [Refereed][Not invited]
     
    Strangulation of the gallbladder by the omentum is extremely rare. We report what to our knowledge is only the second documented case of strangulation of a floating gallbladder by the lesser omentum. A 61-year-old Japanese woman presented to a local hospital after the sudden onset right upper quadrant pain. Her clinical features suggested a gallbladder volvulus, and the patient was referred to our hospital for investigation and treatment. Ultrasonography and computed tomography showed no cholecystolithiasis, but the fundus and body of the gallbladder were markedly swollen without wall thickening, whereas the neck of the gallbladder was normal. A narrowed, twisted area was seen between the body and neck of the gallbladder. Based on these findings, gallbladder volvulus was diagnosed and she underwent emergency laparoscopic cholecystectomy. The fundus and body of the gallbladder were grossly necrotic. The narrowest part of the gallbladder was tightly strangulated by the lesser omentum, but the gallbladder neck was normal. Histopathologic examination of the resected gallbladder showed ischemic changes in the wall of the fundus and body. This case highlights that the clinical features and imaging findings of a gallbladder strangulated by the lesser omentum are similar to those of gallbladder volvulus and that a positive outcome is dependent on a correct diagnosis and prompt surgical management.
  • M Hyodo, N Sata, M Koizumi, Y Sakuma, K Kurihara, A T Lefor, J Ohki, H Nagai, Y Yasuda
    Asian journal of endoscopic surgery 5 (2) 63 - 8 2012/05 
    INTRODUCTION: Laparoscopic splenectomy using pneumoperitoneum has been performed since 1992. The gasless abdominal wall-lifting method for laparoscopic splenectomy was introduced as an alternative. This retrospective study was undertaken to compare results using the two techniques. METHODS: Between 1995 and 2010, 54 patients underwent laparoscopic splenectomy at a single institution; 30 underwent the procedure using the gasless technique and 24 using pneumoperitoneum. There were no significant differences between the two groups regarding age, sex or BMI, but more patients underwent concurrent operations in the pneumoperitoneum group. The abdominal wall-lift system with subcutaneous K-wires was used for the gasless method. RESULTS: Intraoperative blood loss was similar in the two groups (193.0 ± 196.7 mL gasless, 217.3 ± 296.6 mL pneumoperitoneum; P > 0.05), but operative time (182.1 ± 92.1 min, 135.1 ± 46.1 min; P < 0.05), and resected spleen weight (306.1 ± 297.7 g, 138 ± 81.0 g; P < 0.05) were significantly different. In the gasless group, additional procedures included conversion (n = 1), mini-laparotomy (n = 2), and CO(2) insufflation (n = 2). Excluding the concurrent living-related kidney donor patients, hospital stay was similar (6.9 ± 2.5 days, 6.3 ± 2.0 days, P > 0.05). CONCLUSION: Although gasless laparoscopic splenectomy is feasible, there are disadvantages, particularly the restricted operative working space in some patients. These results suggest that either technique may be used on an individual basis in patients undergoing laparoscopic splenectomy.
  • Kazue Morishima, Shin Saito, Daisuke Matsubara, Yoshinori Hosoya, Naohiro Sata, Yoshikazu Yasuda, Shumpei Ishikawa, Toshiro Niki
    CANCER RESEARCH 72 0008-5472 2012/04 [Not refereed][Not invited]
  • Shin Saito, Kazue Morishima, Daisuke Matsubara, Yoshinori Hosoya, Naohiro Sata, Yoshikazu Yasuda, Toshiro Niki
    CANCER RESEARCH 72 0008-5472 2012/04 [Not refereed][Not invited]
  • Yuichi Ishida, Yoshinori Hosoya, Naohiro Sata, Yoshikazu Yasuda, Alan T. Lefor
    JOURNAL OF SURGICAL EDUCATION 69 (2) 167 - 172 1931-7204 2012/03 [Refereed][Not invited]
     
    OBJECTIVE: Although studies have been conducted to identify factors that attract students to a career in surgery, the relative importance of factors that attract students to a particular training program remains unknown. Comparative data between countries may provide insights and ultimately provide guidance to program directors as they seek to attract the best applicants to their program. DESIGN: Blinded written survey, scored 1-5 on a list of 26 factors divided into 3 categories, including educational factors, lifestyle factors, and other. SETTING: Jichi Medical University, Japan and the David Geffen School of Medicine at University of California Los Angeles. PARTICIPANTS: Japan residents (N = 125), Japan Medical Students (N = 68), United States Residents (N = 99), and United States Students (N = 55). RESULTS: All 4 groups surveyed judged faculty quality among the most important factors, with educational program quality, clinical experience and perceptions of resident happiness also rated among the most important. A comparison of factors consistent with lifestyle and factors consistent with the educational program found significantly (p < 0.05) higher scores for educational factors by 3 groups surveyed. CONCLUSIONS: Resident applicants are most interested in training program factors related to the quality of the educational program and the faculty. Issues such as salary, vacation, night call, location, or benefits are considered less important. The results in Japan and the United States were remarkably similar despite major differences in the educational system and debt load at the time of graduation. Program directors should communicate the value of those factors considered important by applicants as part of the recruitment process. (J Surg 69: 167-172. (C) 2012 Association of Program Directors in Surgery. Published by Elsevier Inc. All rights reserved.)
  • Shigeki Matsubara, Tomoyuki Kuwata, Naohiro Sata
    The journal of obstetrics and gynaecology research 38 (1) 350 - 350 1341-8076 2012/01 [Refereed][Not invited]
  • Kazufumi Honda, Takuji Okusaka, Klaus Felix, Shoji Nakamori, Naohiro Sata, Hideo Nagai, Tatsuya Ioka, Akihiko Tsuchida, Takeshi Shimahara, Masashi Shimahara, Yohichi Yasunami, Hideya Kuwabara, Tomohiro Sakuma, Yoshihiko Otsuka, Norihito Ota, Miki Shitashige, Tomoo Kosuge, Markus W Büchler, Tesshi Yamada
    PloS one 7 (10) e46908  1932-6203 2012 [Refereed][Not invited]
     
    BACKGROUND: Among the more common human malignancies, invasive ductal carcinoma of the pancreas has the worst prognosis. The poor outcome seems to be attributable to difficulty in early detection. METHODS: We compared the plasma protein profiles of 112 pancreatic cancer patients with those of 103 sex- and age-matched healthy controls (Cohort 1) using a newly developed matrix-assisted laser desorption/ionization (oMALDI) QqTOF (quadrupole time-of-flight) mass spectrometry (MS) system. RESULTS: We found that hemi-truncated apolipoprotein AII dimer (ApoAII-2; 17252 m/z), unglycosylated apolipoprotein CIII (ApoCIII-0; 8766 m/z), and their summed value were significantly decreased in the pancreatic cancer patients [P = 1.36×10(-21), P = 4.35×10(-14), and P = 1.83×10(-24) (Mann-Whitney U-test); area-under-curve values of 0.877, 0.798, and 0.903, respectively]. The significance was further validated in a total of 1099 plasma/serum samples, consisting of 2 retrospective cohorts [Cohort 2 (n = 103) and Cohort 3 (n = 163)] and a prospective cohort [Cohort 4 (n = 833)] collected from 8 medical institutions in Japan and Germany. CONCLUSIONS: We have constructed a robust quantitative MS profiling system and used it to validate alterations of modified apolipoproteins in multiple cohorts of patients with pancreatic cancer.
  • K. Endo, N. Sata, Y. Kaneda, M. Koizumi, A. Lefor, Y. Yasuda
    PANCREAS 40 (8) 1321 - 1321 0885-3177 2011/11 [Not refereed][Not invited]
  • S. Matsumoto, N. Sata, M. Koizumi, A. Lefor, Y. Yasuda
    PANCREAS 40 (8) 1338 - 1338 0885-3177 2011/11 [Not refereed][Not invited]
  • Tomoyuki Kuwata, Shigeki Matsubara, Rie Usui, Shin-Ichiro Uchida, Naohiro Sata, Mitsuaki Suzuki
    Journal of medical case reports 5 523 - 523 1752-1947 2011/10 [Refereed][Not invited]
     
    INTRODUCTION: Uterine rupture is a life-threatening condition both to mothers and fetuses. Its early diagnosis and treatment may save their lives. Previous myomectomy is a high risk factor for uterine rupture. Intestinal adhesion due to previous myomectomy may also prevent early diagnosis of uterine rupture. CASE PRESENTATION: A 38-year-old primiparous non-laboring Japanese woman with a history of myomectomy was admitted in her 34th week due to lower abdominal pain. Although the pain was slight and her vital signs were stable, computed tomography revealed massive fluid collection in her abdominal cavity, which led us to perform a laparotomy. Uterine rupture had occurred at the site of the previous myomectomy; however, the small intestine was adhered tightly to the rupture, thus masking it. The baby was delivered through a low uterine segment transverse incision. The ruptured uterine wall was reconstructed. CONCLUSION: Intestinal adhesion due to a prior myomectomy occluded a uterine rupture, possibly masking its symptoms and signs, which may have prevented early diagnosis.
  • Yoshinori Hosoya, Alan Lefor, Takashi Ui, Hidenori Haruta, Kentaro Kurashina, Shin Saito, Toru Zuiki, Naohiro Sata, Yoshikazu Yasuda
    Surgical endoscopy 25 (10) 3400 - 4 0930-2794 2011/10 [Refereed][Not invited]
     
    BACKGROUND: To decrease the incidence of internal hernia after laparoscopic gastric bypass, current recommendations include closure of mesenteric defects. Laparoscopic gastric resection is used increasingly for the treatment of gastric cancer, but the incidence of internal hernia in the treated patients has not been studied. METHODS: This study retrospectively reviewed 173 patients who underwent laparoscopic resection for gastric cancer at one institution, including distal and total gastric resections with antecolic Roux-en-Y reconstruction. RESULTS: An internal hernia occurred in 4 (7%) of 58 patients whose jejunojejunal mesenteric defect was not closed a mean of 326 days after surgery. All the patients underwent reoperation with reduction and repair of the hernia. In 115 subsequent cases, with closure of the mesenteric defect, internal hernias did not occur (0/115 cases; p < 0.05). CONCLUSION: Based on the current recommendations for patients undergoing bariatric surgery, closure of this potential hernia defect is mandatory after laparoscopic gastrectomy with a Roux-en-Y reconstruction for gastric cancer.
  • Junichi Matsubara, Kazufumi Honda, Masaya Ono, Shigeki Sekine, Yoshinori Tanaka, Michimoto Kobayashi, Giman Jung, Tomohiro Sakuma, Shoji Nakamori, Naohiro Sata, Hideo Nagai, Tatsuya Ioka, Takuji Okusaka, Tomoo Kosuge, Akihiko Tsuchida, Masashi Shimahara, Yohichi Yasunami, Tsutomu Chiba, Tesshi Yamada
    Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology 20 (10) 2195 - 203 1055-9965 2011/10 [Refereed][Not invited]
     
    BACKGROUND: The aim of this study was to identify a new plasma biomarker for use in early detection of colorectal cancer. METHODS: Using the combination of hollow fiber membrane (HFM)-based low-molecular weight protein enrichment and two-dimensional image converted analysis of liquid chromatography and mass spectrometry (2DICAL), we compared the plasma proteome of 22 colorectal cancer patients with those of 21 healthy controls. An identified biomarker candidate was then validated in two larger cohorts [validation-1 (n = 210) and validation-2 (n = 113)] using a high-density reverse-phase protein microarray. RESULTS: From a total of 53,009 mass peaks, we identified 103 with an area under curve (AUC) value of 0.80 or higher that could distinguish cancer patients from healthy controls. A peak that increased in colorectal cancer patients, with an AUC of 0.81 and P value of 0.0004 (Mann-Whitney U test), was identified as a product of the PLIN2 gene [also known as perilipin-2, adipose differentiation-related protein (ADRP), or adipophilin]. An increase in plasma adipophilin was consistently observed in colorectal cancer patients, including those with stage I or stage II disease (P < 0.0001, Welch's t test). Immunohistochemical analysis revealed that adipophilin is expressed primarily in the basal sides of colorectal cancer cells forming polarized tubular structures, and that it is absent from adjacent normal intestinal mucosae. CONCLUSIONS: Adipophilin is a plasma biomarker potentially useful for the detection of early-stage colorectal cancer. IMPACT: The combination of HFM and 2DICAL enables the comprehensive analysis of plasma proteins and is ideal for use in all biomarker discovery studies.
  • Masaru Koizumi, Naohiro Sata, Naoya Kasahara, Kazue Morishima, Yuji Kaneda, Takehito Fujiwara, Makoto Ota, Masanobu Hyodo, Yoshikazu Yasuda
    Clinical journal of gastroenterology 4 (5) 323 - 330 1865-7257 2011/10 [Refereed][Not invited]
     
    We report two cases of carcinoid tumor of the gallbladder. Case 1 was a 59-year-old woman who presented with epigastric pain. Abdominal ultrasonography and computed tomography (CT) revealed a 16 mm polypoid lesion in the neck of the gallbladder. Tumor markers were within normal limits. Open cholecystectomy was performed with a preoperative diagnosis of early cancer of the gallbladder. Case 2 was a 45-year-old man. A polyp in the gallbladder was incidentally detected on annual checkup. Ultrasound and CT showed an 18 mm protruding lesion in the neck of the gallbladder. Laparoscopic cholecystectomy was performed and the tumor diagnosed as a carcinoid tumor based on the findings of funicular and tubular cells in the lamina propria mucosa, homogeneous nuclei, basophilic cytoplasm, and positive staining with chromogranin A and synaptophysin. The postoperative course of both patients was uneventful, with no recurrence at 44 and 41 months after surgery. In this literature review of 39 cases, classical carcinoid of the gallbladder has a favorable postoperative outcome. Of cases reviewed, 60% are located in the neck of the gallbladder and 50% have a polypoid shape.
  • Takashi Ui, Yoshinori Hosoya, Kentaro Kurashina, Masaaki Sato, Norimasa Seo, Alan Lefor, Naohiro Sata, Yoshikazu Yasuda
    Surgical laparoscopy, endoscopy & percutaneous techniques 21 (4) e213-4 - E214 1530-4515 2011/08 [Refereed][Not invited]
     
    The patient is a 61-year-old man who had previously undergone an extended thymectomy for myasthenia gravis. Endoscopic examination during a routine follow-up visit revealed early gastric cancer in the proximal portion of the stomach. To undergo resection the patient received general and epidural anesthesia. The conditions were unfavorable for laparoscopic-assisted surgery because he had a body mass index of 33 and muscle relaxants could not be used. Pneumoperitoneum was induced with carbon dioxide, and the abdominal wall was lifted. An adequate working space was secured in the upper abdomen and proximal gastrectomy was successfully performed.
  • Hidetoshi Kumano, Yasuo Hozumi, Mikio Shiozawa, Megumi Takehara, Masaru Koizumi, Naohiro Sata, Alan T Lefor, Yoshikazu Yasuda
    The American surgeon 77 (6) e107-8 - E108 0003-1348 2011/06 [Refereed][Not invited]
  • Masaru Koizumi, Yoshinori Hosoya, Katsuya Dezaki, Toshihiko Yada, Hiroshi Hosoda, Kenji Kangawa, Hideo Nagai, Alan T Lefor, Naohiro Sata, Yoshikazu Yasuda
    The Annals of thoracic surgery 91 (4) 1032 - 7 0003-4975 2011/04 [Refereed][Not invited]
     
    BACKGROUND: Esophagectomy after gastric reconstruction leads to significant weight loss. Ghrelin is known to stimulate appetite and cause weight increase. The objective of this study is to examine the relationship of serum ghrelin levels and weight loss in patients after esophagectomy for cancer. METHODS: Twenty-two patients underwent esophagectomy including gastric reconstruction. Serum ghrelin levels and weight were measured preoperatively and then postoperatively for 12 months in all patients. A questionnaire assessed appetite, amount of food eaten, satisfaction, and frequency of eating. RESULTS: Preoperatively, the mean serum ghrelin level was 67.9 ± 42.6 (fmol/mL ± SD), and at 1, 3, 6, and 12 months after surgery were 43.4 ± 28.1, 51.5 ± 32.2, 67.1 ± 50.9, and 84.9 ± 43.1, respectively. Compared with preoperative values, the mean body mass index decreased by 1.9 ± 1.5, 2.3 ± 1.8, 2.1 ± 2.3, 2.4 ± 2.7 at 1, 3, 6, and 12 months after surgery. While appetite score showed a decrease at 1 month (1.6 ± 0.92), appetite increased by 12 months postoperatively (2.7 ± 1.0) and showed a strong positive correlation (r = 0.743) with serum ghrelin levels. There were no significant differences in ghrelin levels when patients were stratified by disease stage, recurrence, or administration of adjuvant chemotherapy. CONCLUSIONS: Esophagectomy resulted in temporary reduction of ghrelin levels, but while levels returned to normal 3 months later, weight loss persisted at 12 months. Further study is needed to elucidate the mechanisms of persistent weight loss and design therapeutic interventions to recover the weight lost.
  • Shin Saito, Kazue Morishima, Daisuke Matsubara, Yoshinori Hosoya, Naohiro Sata, Yoshikazu Yasuda, Shumpei Ishikawa, Toshiro Niki
    CANCER RESEARCH 71 0008-5472 2011/04 [Not refereed][Not invited]
  • Yusuke Murakoshi, Kazufumi Honda, Shizuka Sasazuki, Masaya Ono, Ayako Negishi, Junichi Matsubara, Tomohiro Sakuma, Hideya Kuwabara, Shoji Nakamori, Naohiro Sata, Hideo Nagai, Tatsuya Ioka, Takuji Okusaka, Tomoo Kosuge, Masashi Shimahara, Yohichi Yasunami, Yoshinori Ino, Akihiko Tsuchida, Tatsuya Aoki, Shoichiro Tsugane, Tesshi Yamada
    Cancer science 102 (3) 630 - 8 1347-9032 2011/03 [Refereed][Not invited]
     
    The development of a new plasma biomarker for early detection would be necessary to improve the overall outcome of colorectal cancer. Here we report the identification and validation of the ninth component of complement (C9) as a novel plasma biomarker for colorectal cancer by cutting-edge proteomic technologies. Plasma proteins were enzymatically digested into a large array of peptides, and the relative quantity of a total of 94,803 peptide peaks was compared between 31 colorectal cancer patients and 59 age/sex-matched healthy controls using 2D image-converted analysis of liquid chromatography and mass spectrometry. The selected biomarker candidates were validated in 345 subjects (115 colorectal cancer patients and 230 age/sex-matched healthy controls) using high-density reverse-phase protein microarrays. Plasma levels of Apo AI and C9 in colorectal cancer patients significantly differed from healthy controls with P values of 7.94×10(-4) and 1.43×10(-12) (Student's t-test), respectively. In particular, C9 was elevated in patients with colorectal cancer, including those with stage-I and -II diseases (P=3.01×10(-3) and P=1.13×10(-5) , respectively). Although the significance of the present study must be validated in an independent clinical study, the increment of plasma C9 may be applicable to the early detection of colorectal cancer.
  • Junichi Matsubara, Kazufumi Honda, Masaya Ono, Yoshinori Tanaka, Michimoto Kobayashi, Giman Jung, Koji Yanagisawa, Tomohiro Sakuma, Shoji Nakamori, Naohiro Sata, Hideo Nagai, Tatsuya Ioka, Takuji Okusaka, Tomoo Kosuge, Akihiko Tsuchida, Masashi Shimahara, Yohichi Yasunami, Tsutomu Chiba, Setsuo Hirohashi, Tesshi Yamada
    Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology 20 (1) 160 - 71 1055-9965 2011/01 [Refereed][Not invited]
     
    BACKGROUND: Early detection is essential to improve the outcome of patients with pancreatic cancer. A noninvasive and cost-effective diagnostic test using plasma/serum biomarkers would facilitate the detection of pancreatic cancer at the early stage. METHODS: Using a novel combination of hollow fiber membrane-based low-molecular-weight protein enrichment and LC-MS-based quantitative shotgun proteomics, we compared the plasma proteome between 24 patients with pancreatic cancer and 21 healthy controls (training cohort). An identified biomarker candidate was then subjected to a large blinded independent validation (n = 237, validation cohort) using a high-density reverse-phase protein microarray. RESULTS: Among a total of 53,009 MS peaks, we identified a peptide derived from CXC chemokine ligand 7 (CXCL7) that was significantly reduced in pancreatic cancer patients, showing an area under curve (AUC) value of 0.84 and a P value of 0.00005 (Mann-Whitney U test). Reduction of the CXCL7 protein was consistently observed in pancreatic cancer patients including those with stage I and II disease in the validation cohort (P < 0.0001). The plasma level of CXCL7 was independent from that of CA19-9 (Pearson's r = 0.289), and combination with CXCL7 significantly improved the AUC value of CA19-9 to 0.961 (P = 0.002). CONCLUSIONS: We identified a significant decrease of the plasma CXCL7 level in patients with pancreatic cancer, and combination of CA19-9 with CXCL7 improved the discriminatory power of the former for pancreatic cancer. IMPACT: The present findings may provide a new diagnostic option for pancreatic cancer and facilitate early detection of the disease.
  • Yoshito Nihei, Makiko Tahara, Hakari Morishima, Masanobu Hyoudou, Naohiro Sata, Toshiro Niki, Yoshikazu Yasuda
    Japanese Journal of Gastroenterological Surgery 44 (3) 266 - 272 1348-9372 2011 [Refereed][Not invited]
     
    We report an extremely rare case of solitary liver metastasis from papillary thyroid carcinoma. A 56-year-old woman referred for a lung-cancer screening-detected liver tumor. Her medical history included right thyroid lobectomy for papillary carcinoma 18 years earlier and total thyroidectomy for adenoma-tous goiter 2 years thereafter. Blood tests showed markedly-elevated preoperative serum thyroglobulin. Computed tomography (CT) showed a lateral hepatic tumor with a central scar and capsule-like structure. Contrast medium enhanced the lesion in the early phase, with washout in the late phase. Magnetic resonance imaging (MRI) showed lesions in the left seventh rib and first lumbar vertebra in the same phase as the liver tumor. Whole-body bone scintigraphy showed increased tracer uptake in the sixth thoracic vertebra and seventh rib, yielding a diagnosis of solitary liver tumor with multiple bone metastases. The liver tumor was suspected of being hepatocellular carcinoma and liver metastases from thyroid cancer. The liver tumor was resected concomitant to lateral segmentectomy with rib biopsy. Histo-pathologically, both lesions were papillary thyroid carcinoma metastases. © 2011 The Japanese Society of Gastroenterological Surgery.
  • Naohiro Sata
    PANCREAS 39 (5) 701 - 701 0885-3177 2010/07 [Not refereed][Not invited]
  • Tooru Shimosegawa, Keisho Kataoka, Terumi Kamisawa, Hiroyuki Miyakawa, Hirotaka Ohara, Tetsuhide Ito, Satoru Naruse, Naohiro Sata, Koichi Suda, Morihisa Hirota, Yoshifumi Takeyama, Keiko Shiratori, Takashi Hatori, Makoto Otsuki, Yutaka Atomi, Kentaro Sugano, Masao Tanaka
    Journal of gastroenterology 45 (6) 584 - 91 0944-1174 2010/06 [Refereed][Not invited]
     
    In Japan, we are now using the clinical diagnostic criteria for chronic pancreatitis (CP) that were revised in 2001 to add the findings of magnetic resonance cholangiopancreatography to the criteria compiled by the Japan Pancreas Society (JPS) in 1995. Because the current criteria are set for diagnosing advanced CP, they are unlikely to improve patients' prognoses. In addition, they seem unsuitable for current clinical practice because exocrine pancreatic function tests, which have become obsolete in Japan, are included in the diagnostic factors. For these reasons, the Research Committee on Intractable Pancreatic Diseases supported by the Ministry of Health, Labour and Welfare of Japan, the JPS and the Japanese Society of Gastroenterology have revised the criteria. The revised criteria are unique in that they contain an introduction to the concept of early CP. It is a challenge aimed at improvement of the long-term prognosis of CP patients by early diagnosis and therapeutic intervention in this disease. We need to determine and clarify the clinico-pathological outcome of early CP by a prospective long-term follow-up of the patients in this category.
  • Kazufumi Honda, Masaya Ono, Takuji Okusaka, Tomoo Kosuge, Klaus Felix, Shoji Nakamori, Naohiro Sata, Hideo Nagai, Tatsuya Loka, Akihiko Tsuchida, Masashi Shimahara, Yoichi Yasunami, Setsuo Hirohashi, Markus W. Buchler, Tesshi Yamada
    CANCER RESEARCH 70 0008-5472 2010/04 [Not refereed][Not invited]
  • Masaru Koizumi, Naohiro Sata, Naoya Kasahara, Kazue Morishima, Hideki Sasanuma, Yasunaru Sakuma, Atsushi Shimizu, Masanobu Hyodo, Yoshikazu Yasuda
    JOP : Journal of the pancreas 11 (1) 36 - 40 1590-8577 2010/01 [Refereed][Not invited]
     
    CONTEXT: Although surgical resection is the only curative therapeutic option for recurrent or metachronous pancreatic carcinomas, most such cancers are beyond surgical curability. We herein report on two rare cases of remnant pancreatectomy used to treat recurrent or metachronous pancreatic carcinomas. CASE REPORTS: CASE#1 A 65-year-old male developed weight loss and diabetes mellitus 83 months after a pylorus-preserving pancreaticoduodenectomy followed by two years of adjuvant chemotherapy (5-fluorouracil plus leucovorin plus mitomycin C) for a pancreatic carcinoma in the head of the pancreas (stage IA). An abdominal CT scan revealed a 3 cm tumor in the remnant pancreas which appeared as a 'hot' nodule on FDG-PET. A remnant distal pancreatectomy was performed and a pancreatic carcinoma similar in profile to the primary lesion (stage IIB) was confirmed pathologically. CASE#2 A 67-year-old male showed increased CA 19-9 levels 25 months after a distal pancreatectomy for a pancreatic carcinoma in the body of the pancreas (stage IA). An abdominal CT scan revealed a cystic lesion in the cut end of the pancreas which appeared as a 'hot' nodule on FDG-PET. A remnant proximal pancreatectomy with duodenectomy was performed and a metachronous pancreatic carcinoma (stage III) was confirmed pathologically. CONCLUSION: Remnant pancreatectomy can be considered a treatment option for recurrent or metachronous pancreatic carcinomas. FDG-PET can play a key role in detecting remnant pancreatic carcinomas.
  • Hisashi Hatanaka, Mamiko Tsukui, Shuji Takada, Kentaro Kurashina, Young Lim Choi, Manabu Soda, Yoshihiro Yamashita, Hidenori Haruta, Toru Hamada, Toshihide Ueno, Kiichi Tamada, Yoshinori Hosoya, Naohiro Sata, Yoshikazu Yasuda, Hideo Nagai, Kentaro Sugano, Hiroyuki Mano
    Cancer science 101 (1) 54 - 9 1347-9032 2010/01 [Refereed][Not invited]
     
    Gallbladder cancer (GBC) is a highly fatal malignancy in humans. Genetic alterations in KRAS or TP53 as well as overexpression of ERBB2 have been shown to contribute to the development of certain types of GBC. However, many cases of GBC do not harbor such genetic changes, with other transforming events awaiting discovery. We here tried to identify novel cancer-promoting genes in GBC, with the use of a retroviral cDNA expression library. A retroviral cDNA expression library was constructed from a surgically resected clinical specimen of GBC, and was used to infect 3T3 fibroblasts in a focus formation assay. cDNA incorporated into the transformed foci was rescued by PCR. One such cDNA was found to encode free fatty acid receptor 2 (FFAR2), a G protein-coupled receptor for short-chain fatty acids. The oncogenic potential of FFAR2 was confirmed both in vitro with the focus formation assay and by evaluation of cell growth in soft agar as well as in vivo with a tumorigenicity assay in nude mice. The isolated FFAR2 cDNA had no sequence alterations, suggesting that upregulation of FFAR2 expression may contribute to malignant transformation. Indeed, all of quantitative RT-PCR, in situ hybridization, and immunohistochemical analyses showed that the amount of FFAR2 mRNA and its protein product was increased in digestive tract cancer specimens. Furthermore, short-chain fatty acids potentiated the mitogenic action of FFAR2 in 3T3 cells. Our data thus, for the first time, implicate FFAR2 in carcinogenesis of the digestive tract.
  • Hisashi Hatanaka, Shuji Takada, Mamiko Tsukui, Young Lim Choi, Kentaro Kurashina, Manabu Soda, Yoshihiro Yamashita, Hidenori Haruta, Toru Hamada, Kiichi Tamada, Yoshinori Hosoya, Naohiro Sata, Hideo Nagai, Yoshikazu Yasuda, Kentaro Sugano, Hiroyuki Mano
    Cancer science 101 (1) 60 - 4 1347-9032 2010/01 [Refereed][Not invited]
     
    To identify novel cancer-promoting genes in biliary tract cancer (BTC), we constructed a retroviral cDNA expression library from a clinical specimen of BTC with anomalous pancreaticobiliary duct junction (APBDJ), and used the library for a focus formation assay with 3T3 fibroblasts. One of the cDNAs rescued from transformed foci was found to encode Indian hedgehog homolog (IHH). The oncogenic potential of IHH was confirmed both in vitro with the focus formation assay and in vivo with a tumorigenicity assay in nude mice. The isolated IHH cDNA had no sequence alterations, suggesting that upregulation of IHH expression may contribute to malignant transformation. Quantitation of IHH mRNA among clinical specimens has revealed that the expression level of IHH in BTC with APBDJ is higher than that in BTC without APBDJ and than in non-cancerous biliary tissues. Our data thus implicate a direct role of IHH in the carcinogenesis of BTC with APBDJ.
  • Kazue Morishima, Masanobu Hyodo, Yoshito Nihei, Naohiro Sata, Yoshikazu Yasuda
    Japanese Journal of Cancer and Chemotherapy 37 (1) 127 - 129 0385-0684 2010 [Refereed][Not invited]
     
    A 65-year-old man underwent a total gastrectomy and distal pancreatectomy for acinar cell carcinoma of the pancreas. Multiple metastatic liver lesions were found one year postoperatively. He was treated with S-1 chemotherapy over 34 months, and the tumors significantly reduced in size without severe side effects. Four years after surgery, the liver metastases increased in size, associated with pain especially in the right upper quadrant. We then performed right hepatectomy. Peritoneal dissemination and multiple lung metastases were found 8 months after liver resection. Acinar cell carcinoma of the pancreas is a rare and highly malignant tumor, and there are few reports regarding treatment with chemotherapy. Herein, we report a case with multiple liver metastases which were controlled by systemic chemotherapy using S-1.
  • Masaru Koizumi, Katsuya Dezaki, Hiroshi Hosoda, Boldbaatar Damdindorj, Hideyuki Sone, Lu Ming, Yoshinori Hosoya, Naohiro Sata, Eiji Kobayashi, Kenji Kangawa, Hideo Nagai, Yoshikazu Yasuda, Toshihiko Yada
    International journal of peptides 2010 1687-9767 2010 [Refereed][Not invited]
     
    Gastrectomy reduces food intake and body weight (BW) hampering recovery of physical conditions. It also reduces plasma levels of stomach-derived orexigenic ghrelin. This study explored changes in orexigenic ghrelin system in rats receiving total gastrectomy with Billroth II (B-II) or Roux-en-Y (R-Y) method. Feeding and BW were reduced by gastrectomy and subsequently recovered to a greater extent with R-Y than B-II while plasma ghrelin decreased similarly. At postoperative 12th week, ghrelin contents increased in the duodenum and pancreas, plasma ghrelin levels increased upon fasting, and ghrelin injection promoted feeding but not in earlier periods. In summary, gastrectomized rats partially recover feeding and BW, in a reconstruction-dependent manner. At 12th week, ghrelin is upregulated in extra-stomach tissues, plasma ghrelin levels are physiologically regulated, and orexigenic effect of exogenous ghrelin is restored. This time-related recovery of ghrelin system may provide a strategy for promoting feeding, BW, and thereby physical conditions in gastrectomized patients.
  • Atsushi Miki, Ricordi Camillo, Yasunaru Sakuma, Ryosuke Misawa, Luca Inverardi, Antonello Pileggi, Naohiro Sata, Yoshikazu Yasuda, Hirohito Ichii
    AMERICAN JOURNAL OF TRANSPLANTATION 10 78 - 78 1600-6135 2010/01 [Not refereed][Not invited]
  • Masaya Ono, Junichi Matsubara, Kazufumi Honda, Tomohiro Sakuma, Tomoyo Hashiguchi, Hiroshi Nose, Shoji Nakamori, Takuji Okusaka, Tomoo Kosuge, Naohiro Sata, Hideo Nagai, Tatsuya Ioka, Sachiko Tanaka, Akihiko Tsuchida, Tatsuya Aoki, Masashi Shimahara, Yohichi Yasunami, Takao Itoi, Fuminori Moriyasu, Ayako Negishi, Hideya Kuwabara, Ayako Shoji, Setsuo Hirohashi, Tesshi Yamada
    The Journal of biological chemistry 284 (42) 29041 - 9 0021-9258 2009/10 [Refereed][Not invited]
     
    Plasma proteome analysis requires sufficient power to compare numerous samples and detect changes in protein modification, because the protein content of human samples varies significantly among individuals, and many plasma proteins undergo changes in the bloodstream. A label-free proteomics platform developed in our laboratory, termed "Two-Dimensional Image Converted Analysis of Liquid chromatography and mass spectrometry (2DICAL)," is capable of these tasks. Here, we describe successful detection of novel prolyl hydroxylation of alpha-fibrinogen using 2DICAL, based on comparison of plasma samples of 38 pancreatic cancer patients and 39 healthy subjects. Using a newly generated monoclonal antibody 11A5, we confirmed the increase in prolyl-hydroxylated alpha-fibrinogen plasma levels and identified prolyl 4-hydroxylase A1 as a key enzyme for the modification. Competitive enzyme-linked immunosorbent assay of 685 blood samples revealed dynamic changes in prolyl-hydroxylated alpha-fibrinogen plasma level depending on clinical status. Prolyl-hydroxylated alpha-fibrinogen is presumably controlled by multiple biological mechanisms, which remain to be clarified in future studies.
  • Shin Saito, Yoshinori Hosoya, Toru Zuiki, Masanobu Hyodo, Alan Lefor, Naohiro Sata, Michitaka Nagase, Masanori Nakazawa, Daisuke Matsubara, Toshiro Niki, Yoshikazu Yasuda
    ESOPHAGUS 6 (3) 177 - 181 1612-9059 2009/09 [Refereed][Not invited]
     
    We reviewed the clinicopathological characteristics of 14 patients who underwent resection of basaloid squamous carcinoma (BSC) of the esophagus. The mean age was 65.3 years, and all patients were male. Seven patients had superficial BSCs and 7 had advanced BSCs. BSCs were associated with high rates of lymph node metastases and venous invasion. With regard to immunohistochemistry, the rate of cyclin D1 expression was higher (13/14), and the preservation rate of E-cadherin expression was lower (4/14), than that seen in ordinary esophageal squamous cell carcinoma. Squamous cell carcinoma components were most often found at sites of lymph node metastases, whereas basaloid components predominated at sites of hematogenous metastases in 4 patients, including lung, brain, and liver. Seven of the 9 patients with stage I or II disease are alive without recurrence. All patients with stage III or IV tumors developed recurrent disease. Primary tumors responded well in 3 patients who received preoperative chemotherapy (5-fluorouracil plus cisplatin) and/or radiotherapy, but further studies are needed to clarify the role of chemoradiotherapy. We believe that control of the hematogenous spread of basaloid components may lead to improved outcomes in patients with esophageal BSC.
  • Kazuhiro Endo, Naohiro Sata, Kunihiko Shimura, Yoshikazu Yasuda
    JOP : Journal of the pancreas 10 (1) 59 - 63 2009/01 [Refereed][Not invited]
     
    CONTEXT: Although rare, a pancreatic arteriovenous malformation can have serious consequences. A diagnosis of arteriovenous malformation requires evidence of aberrant communication between the arterial and the venous systems. This report describes a case where the use of multi-detector row CT and specific post-processing methods provided a diagnosis of arteriovenous malformation. This minimally invasive diagnostic approach resulted in a clear, precise and comprehensive visual representation of the pancreatic arteriovenous malformation. CASE REPORT: A 60-year-old man with right hypochondriac pain presented with a mass in the head of the pancreas. The hypochondriac pain resolved spontaneously and physical examination revealed no abnormal findings. A multi-detector row CT study was performed. The data obtained in the arterial phase demonstrated a high-contrast mass in the head of the pancreas and early enhancement of the portal vein. A maximum intensity projection method clarified the aberrant vascular communication. Changes in Hounsfield numbers were observed using a multi-planar reformation method. A volume-rendering method was used to create a 3D model which demonstrated the spatial relationship between the aberrant vascular communication and the surrounding tissue. An annual follow-up study using this technique showed no significant alteration. CONCLUSIONS: Multi-detector row CT with specific post-processing methods is a useful diagnostic tool for pancreatic arteriovenous malformation.
  • Mikio Shiozawa, Naohiro Sata, Kazuyuki Endo, Masaru Koizumi, Yosikazu Yasuda, Hideo Nagai, Hiroshi Takakusaki
    ABDOMINAL IMAGING 34 (1) 113 - 120 0942-8925 2009/01 [Refereed][Not invited]
     
    Retroperitoneal endoscopic adrenalectomy (EA) is recognized as a principal procedure for benign adrenal tumors. However, a limited visual field and a narrow working space make this approach difficult, particularly in cases of obese patients or small tumors. Using multidetector row CT (MD-CT), this study investigated the use of preoperative virtual simulation (PVS) to identify tumor and central vein locations for EA, and verified these findings during EA surgery. The study enrolled 11 cases comprising 10 adrenal adenomas and one ACTH-independent macronodular adrenal hyperplasia admitted to Jichi Medical University Hospital, Tochigi, Japan, between November 2003 and October 2006. Patients were evaluated in a lateral bending position using MD-CT. 3D PVS images of ribs, vertebrae, kidneys, and adrenal tumors were generated and compared with real images obtained during EA. The PVS images clearly showed the relative locations of the adrenal tumor, kidney, and adjacent anatomical structures. These locations were verified during EA. The central vein was identified in the PVS images in all cases. Information derived from the PVS images assisted in the performance of EA surgery. Preoperative 3D-simulation images using MD-CT contributed to the safety and efficiency of performing EAs.
  • Naohiro Sata, Kentaro Kurashina, Hideo Nagai, Takukazu Nagakawa, Osamu Ishikawa, Tetsuo Ohta, Masaaki Oka, Hisafumi Kinoshita, Wataru Kimura, Hiroshi Shimada, Masao Tanaka, Akimasa Nakao, Kouichi Hirata, Hideki Yasuda
    Journal of hepato-biliary-pancreatic surgery 16 (4) 485 - 92 0944-1166 2009 [Refereed][Not invited]
     
    BACKGROUND: Pancreatic carcinoma causes more than 20,000 deaths every year in Japan. The role of (neo-) adjuvant chemotherapy for pancreatic carcinoma is still controversial. METHODS: At the 34th Annual Meeting of the Japanese Society of Pancreatic Surgery in 2007, questionnaires were distributed regarding the use of (neo-) adjuvant chemo(radio)therapy for pancreatic carcinoma between 2001 and 2005. RESULTS: Sixty of the 146 member institutions responded to the questionnaires. There were a total of 1,846 cases of resected pancreatic carcinoma between 2001 and 2005. The study population had a greater proportion of males, and a mean age of 65.3 years (range 34-90 years). The lesion was located in the head of the pancreas in 1,204 cases (71.7%), in the body in 353 cases (21.0%), and in the tail in 111 cases (6.6%). Overall survival rates were 67.3% at 1 year, 36.0% at 2 years, and 23.9% at 3 years, respectively. Adjuvant chemotherapy (usually involving gemcitabine) was used in 66.0% of cases. The use of adjuvant chemotherapy was found to improve the overall survival rate. Interestingly, adjuvant chemotherapy only improved survival in late-stage (UICC stages IIB, III, and IV) but not early stage (IA, IB, and IIA) patients. Survival was treatment duration-dependent, with patients who received more than 12 months of therapy having a 3-year survival rate of 51.2%. CONCLUSION: This high volume retrospective data indicated the promising effect of gemcitabine-based adjuvant chemotherapy and the rational duration of adjuvant chemotherapy should be determined in the future prospective studies.
  • Masaru Koizumi, Naohiro Sata, Koji Yoshizawa, Katsumi Kurihara, Yoshikazu Yasuda
    Case reports in gastroenterology 1 (1) 103 - 9 2007/10 [Refereed][Not invited]
     
    A 60-year-old man presented with melena and hematemesis in 1984. Esophagogastroduodenoscopy (EGD) detected a small protruding lesion in the duodenal bulb, which was diagnosed as Brunner's adenoma. No significant change was detected in subsequent annual EGD and biopsies for 10 years, after which the patient was not observed for 7 years. The patient presented with melena again in 2001. The lesion had changed shape to become a 10 mm sessile tumor with a central depression, and following a biopsy was diagnosed as an adenocarcinoma. The patient underwent partial resection of the duodenum. Histopathological assessment showed acidophilic cells with swollen nuclei, and clear cells forming a tubular or papillary tubule in the mucosal lamina propria and submucosal layer. The tumor cells stained positive for lysozyme, indicating that they arose from Brunner's gland. The patient showed no sign of recurrence and was disease-free for more than 34 months after surgery. The patient died of pneumonia. This is an extremely rare case of primary duodenal carcinoma arising from Brunner's gland in a patient observed for 17 years.
  • Masaru Koizumi, Naohiro Sata, Kunihiko Shimura, Munetoshi Tsukahara, Katsumi Kurihara, Masanobu Hyodo, Yoshikazu Yasuda, Hideo Nagai
    JOURNAL OF GASTROENTEROLOGY AND HEPATOLOGY 22 A248 - A248 0815-9319 2007/10 [Not refereed][Not invited]
  • Masaru Koizumi, Katsuya Dezaki, Hiroshi Hosoda, Kenji Kangawa, Yoshinori Hosoya, Naohiro Sata, Yoshikazu Yasuda, Hideo Nagai, Toshihiko Yada
    GASTROENTEROLOGY 132 (4) A338 - A338 0016-5085 2007/04 [Not refereed][Not invited]
  • N. Sata, K. Endo, K. Shimura, M. Koizumi, H. Nagai
    ABDOMINAL IMAGING 32 (1) 66 - 72 0942-8925 2007/02 [Not refereed][Not invited]
     
    Recent advances in multidetector row computed tomography (MD-CT) technology provide new opportunities for clinical diagnoses of various diseases. Here we assessed CT virtual duodenoscopy, duodenography, and three-dimensional (3D) multicholangiography created by MD-CT for clinical diagnosis of duodenal malignant lesions. The study involved seven cases of periduodenal carcinoma (four ampullary carcinomas, two duodenal carcinomas, one pancreatic carcinoma). Biliary contrast medium was administered intravenously, followed by intravenous administration of an anticholinergic agent and oral administration of effervescent granules for expanding the upper gastrointestinal tract. Following intravenous administration of a nonionic contrast medium, an upper abdominal MD-CT scan was performed in the left lateral position. Scan data were processed on a workstation to create CT virtual duodenoscopy, duodenography, 3D multicholangiography, and various postprocessing images, which were then evaluated for their effectiveness as preoperative diagnostic tools. Carcinoma location and extent were clearly demonstrated as defects or colored low-density areas in 3-D multicholangiography images and as protruding lesions in virtual duodenography and duodenoscopy images. These findings were confirmed using multiplanar or curved planar reformation images. In conclusion, CT virtual duodenoscopy, doudenography, 3-D multicholangiography, and various images created by MD-CT alone provided necessary and adequate preoperative diagnostic information.
  • Naohiro Sata, Akira Kurogochi, Kazuhiro Endo, Kunihiko Shimura, Masaru Koizumi, Hideo Nagai
    JOP : Journal of the pancreas 8 (1) 44 - 9 1590-8577 2007/01 [Refereed][Not invited]
     
    CONTEXT: Primary pancreatic lymphoma is a rare form of extranodal lymphoma originating in the pancreas. The present report describes a case of follicular lymphoma of the pancreas with unique CT and MRI findings. CASE REPORT: A 58-year-old male complained of sudden abdominal pain, and routine ultrasonography detected an 8 cm hypoechoic tumor in the head of the pancreas. The 3D image generated using multi-cholangiography and virtual duodenography provided the information necessary for a laparotomy. The tumor was enucleated for diagnosis. Follicular lymphoma is quite rare in the pancreas and gastrointestinal tract. A considerable number of pancreatic lymphoma subtypes have been reported. The expression "pancreatic lymphoma" has been used to describe both primary lymphoid neoplasms originating in the pancreatic parenchyma and tumors invading from a peri-pancreatic lymphadenopathy. The present case belongs to the latter, which might explain the unique imaging findings and histological type. These subtypes display different imaging findings and different clinical characteristics. In the future, primary pancreatic lymphoma should be discussed separately depending on the subtype. CONCLUSION: We propose a new subtype of primary pancreatic lymphoma. Multi-cholangiography and virtual duodenography provided the information necessary for a laparotomy in the present case. Enucleation is indicated for benign and low-grade malignant tumors of the pancreas, even if the tumor is located in the head of the pancreas.
  • Naohiro Sata, Masaru Koizumi, Hideo Nagai
    Journal of gastroenterology 42 Suppl 17 (Supplement 17) 131 - 4 0944-1174 2007/01 [Refereed][Not invited]
     
    Alcoholic chronic pancreatitis (CP) is not usually diagnosed until the end stage of the disease, and hence enormous medical and social resources are consumed in the treatment of established alcoholic CP. With the aim of early diagnosis and prevention of alcoholic CP, we here propose "alcoholic pancreatopathy" as a new category of pancreatic disorder induced by alcohol intake. In addition to a history of excessive alcohol intake (>80 g/day), the presence of at least one of the following conditions establishes the diagnosis of alcoholic pancreatopathy: 1. History of alcoholic acute pancreatitis. 2. Recurrent abdominal pain or gastrointestinal symptoms induced by alcohol intake. 3. Hyperamylasemia or a high serum level of any other pancreatic enzymes. 4. Abnormal findings in the pancreas by routine abdominal ultrasonography. Alcoholic pancreatopathy is a comprehensive concept that includes the early stage of pancreatic injury induced by alcohol, and is useful for detecting the preclinical stage of pancreatic injury induced by alcohol and hence for treating the early stage of the disease. Further assessments and well-designed studies for investigating the early stage of alcoholic CP are necessary, in which alcoholic pancreatopathy could play a key role.
  • Jianfeng Bai, Naohiro Sata, Hideo Nagai
    HPB : the official journal of the International Hepato Pancreato Biliary Association 9 (2) 150 - 5 1365-182X 2007 [Refereed][Not invited]
     
    BACKGROUND/AIMS: Current in vitro drug sensitivity tests have limitations and disadvantages. This study investigated the use of gene expression data to predict the sensitivity of pancreatic cancers to gemcitabine. MATERIALS AND METHODS: Cancer cells isolated from 14 pancreatic cancer patients were tested in vitro for gemcitabine sensitivity using the collagen droplet drug sensitivity test (CD-DST). On the basis of this test, 9 of the 14 cancers were identified as either gemcitabine-sensitive or gemcitabine-resistant. Total RNA was extracted from each of those nine cancers and used as a template to synthesize Cy3-labeled cDNA. Pancreatic RNA extracted from six normal individuals was used as a control. Labeled probes were hybridized to an Atlas Glass Human 1.0 Microarray chip, after which the chips were washed and scanned, and the data were analyzed using Microsoft Excel-embedded software. The expression profiles of selected genes were confirmed using real-time PCR analysis. RESULTS: Statistical analysis of the microarray data showed that four genes were differentially expressed in gemcitabine-sensitive cancers: microsomal glutathione S-transferase 1 (GSTT1), topoisomerase II alpha (TOP2A), caspase 3, and ATP-binding cassette and subfamily C member 2 (ABCC2). More than 20 other genes were additionally identified as possible candidate genes associated with drug resistance. CONCLUSIONS: Expression of drug resistance-related genes appeared to predict whether a cancer was gemcitabine-sensitive or -resistant. Further study will enable a drug resistance scoring system to be established on the basis of gene expression. Such a system will allow more efficient application of chemotherapy.
  • Follicular lymphoma of the pancreas: a case report and proposed new strategies for diagnosis and surgery of benign or low-grade malignant lesions of the head of the pancreas.
    Sata N, Kurogochi A, Endo K, Shimura K, Koizumi M, Nagai H.on, xa
    JOP 8 (1) 66 - 72 2007 [Not refereed][Not invited]
  • Noboru Yamagata, Jyunko Fujio, Risen Hirai, Mutsumi Matsumaru, Satoshi Tanimura, Chiho Inokuchi, Tateki Shikai, Naoki Takezako, Michiyo Nasu, Yoichi Sakata, Naohiro Sata, Hideo Nagai, Ken Saito, Akiyoshi Miwa
    International journal of hematology 84 (1) 70 - 3 0925-5710 2006/07 [Refereed][Not invited]
     
    Hepatic amyloidosis complicated with Castleman's disease is quite rare. A 48-year-old woman was referred to our hospital with general fatigue, low-grade fever, anemia, thrombocythemia, and liver dysfunction. Physical examination revealed anemia and hepatomegaly and abdominal computed tomography showed marked hepatomegaly and right upper abdominal masses. Technetium-99m pyrophosphate (99mTc-PYP) scintigraphy revealed the diffuse abnormal uptake of the enlarged liver, suggesting amyloid deposition. Liver biopsy showed destruction of the liver structure and the massive deposition of AA type amyloid protein. Surgical resection was performed on the abdominal masses. Histological examination of the masses showed Castleman's disease (plasma cell type). After resection, her fever resolved and the liver size gradually decreased to within the normal range. This case shows that surgical resection of the main lesion is effective for hepatomegaly due to AA type amyloidosis associated with Castleman's disease.
  • N Sata, K Kurihara, M Koizumi, M Tsukahara, K Yoshizawa, H Nagai
    ABDOMINAL IMAGING 31 (3) 326 - 331 0942-8925 2006/06 [Not refereed][Not invited]
     
    We sought to validate computed tomographic virtual pancreatoscopy (CT-VP) created by multidetector row CT (MD-CT) in the clinical diagnosis of intraductal papillary mucinous neoplasm (IPMN) of the pancreas. Five cases of pancreatic IPMNs were included in this study. A nasopancreatic drainage tube was inserted and the pancreatic duct was filled with contrast medium, after which an upper abdominal scan was performed by MD-CT. CT-VP and three-dimensional (3D) CT pancreatographic images were created using a workstation and compared with images by conventional diagnostic techniques. All cases were evaluated by endoscopic retrograde pancreatography (ERP) and three cases of main duct type were assessed by intraoperative real pancreatoscopy (RP). In the main duct cases, papillary projections in the main pancreatic duct and branch orifices were clearly detected by CT-VP. These lesions and structures were confirmed by intraoperative RP, and the CT-VP images were clearer than RP images. In branch cases, a surface-rendering method allowed protruding lesions to be clearly detected in the dilated branches. Compared with conventional ERP or RP, CT-VP and 3D-CT pancreatographic images were finer in quality, and the procedures were less invasive, faster, and less expensive. The potential shown by CT-VP with 3D-CT pancreatography in the clinical diagnosis of pancreatic IPMNs suggests that this approach may replace ERP in the near future.
  • N Sata, M Shiozawa, A Suzuki, K Kurihara, J Ohki, H Nagai
    SURGICAL ENDOSCOPY AND OTHER INTERVENTIONAL TECHNIQUES 20 (5) 830 - 833 0930-2794 2006/05 [Not refereed][Not invited]
     
    Although hand-assisted laparoscopic surgery (HALS) is very common in various laparoscopic procedures, it is rarely used for retroperitoneal endoscopic adrenalectomy because of the small working area. The authors evaluate HALS in endoscopic adrenalectomy with respect to its use as a rescue procedure in complicated cases. In their department, 47 patients underwent endoscopic adrenalectomies between 1998 and 2004. Mainly because of complicated anatomy, three primary aldosteronism cases were converted to retroperitoneal HALS. This involved making an additional 6 cm skin incision, into which the surgeon's left hand was inserted, with the palm used to create a sufficient visual field and working area. The fingers were used for tactile sensation and blunt resection. For these three cases, successful retroperitoneal HALS in endoscopic adrenalectomy resulted in no mortality or morbidity. These findings indicate that this procedure is a feasible technique for complicated benign adrenal tumor cases.
  • Masaru Koizumi, Naohiro Sata, Yoshikazu Yasuda, Hideo Nagai, Yoshihiro Saito, Yuji Hayashi, Kazuyuki Shimada
    Surgery today 36 (5) 425 - 35 0941-1291 2006 [Refereed][Not invited]
     
    PURPOSE: We compiled a manual aimed at reducing preoperative cardiac assessment costs and defining the roles of surgeons and cardiologists. We tested prospectively and retrospectively if this manual achieved these goals. METHODS: Using the Guidelines for Perioperative Cardiovascular Evaluation for Noncardiac Surgery of the American College of Cardiology (ACC) / American Heart Association (AHA), and other articles as a reference, we compiled the Jichi Medical School Hospital (JMSH) Manual in September 2002. This manual contains a novel checklist and flowcharts and includes all past and present cardiac disorders, complications, abnormalities in electrocardiograms (ECGs) and chest X-rays, and evaluation of daily activity. Using this manual, we prospectively studied 1087 surgical candidates from September 2002 to August 2003, and retrospectively analyzed 927 surgical candidates from September 2001 to August 2002. RESULTS: In the prospective study, 39 (3.6%) patients were deemed to require further cardiac assessment and 4 (0.37%) suffered postoperative complications. In the retrospective study, 108 (11.7%) were deemed to require further cardiac assessment and 20 (2.2%) suffered postoperative complications. Using this manual reduced preoperative cardiac examination costs by 1323,600 Japanese yen, representing a 70.5% reduction. CONCLUSIONS: The JMSH Manual defines the roles of surgeons and cardiologists and is useful for assessing preoperative cardiac function and surgical risks. This manual dramatically reduced the costs associated with preoperative cardiac examinations.
  • Masaru Koizumi, Naohiro Sata, Koji Yoshizawa, Munetoshi Tsukahara, Katsumi Kurihara, Yoshikazu Yasuda, Hideo Nagai
    World journal of surgical oncology 3 70 - 70 1477-7819 2005/10 [Refereed][Not invited]
     
    BACKGROUND: Fistula formation has been reported in intraductal papillary-mucinous neoplasms (IPMNs) with or without invasion of the adjacent organs. The presence or absence of invasion is mostly determined by postoperative histological examination rather than by preoperative work-up. CASE PRESENTATION: A 72 year-old Japanese woman showed remarkable dilatation of the main pancreatic duct (MPD) in the distal region of the pancreas. Subsequent ERCP also showed MPD dilatation, after which the patient suffered moderate pancreatitis. A subsequent gastroscopy revealed a small ulceration that had not been observed in a gastroscopy performed 3 months prior. Mucinous discharge from the ulceration suggested it might be the orifice of a fistula connected to the MPD. En bloc resection including the distal region of the pancreas, spleen, stomach and part of the transverse colon was performed under the pre- and intraoperative diagnosis of an invasive malignant IPMN. However, histopathology revealed the lesion to be of "borderline malignancy" without apparent invasion of the stomach. Light microscopy showed inflammatory cellular infiltrates (mainly neutrophils) around the pancreatogastric fistula, but there was no evidence of neoplastic epithelia lining the fistulous tract. CONCLUSION: This case highlights that a pancreatogastric fistula can develop after acute inflammation of the pancreas in the absence of cancer invasion. Further information regarding IPMN-associated fistulae is necessary to clarify the pathogenesis, diagnosis, appropriate surgical intervention and prognosis for this disorder.
  • Ning Wang, Shuichi Tsuruoka, Hisashi Yamamoto, Shin Enosawa, Takeshi Omasa, Naohiro Sata, Toshiharu Matsumura, Hideo Nagai, Akio Fujimura
    Artificial organs 29 (8) 681 - 4 0160-564X 2005/08 [Refereed][Not invited]
     
    A novel recombinant human hepatic cell line, CYP3A4- and glutamine synthetase (GS, an enzyme which converts ammonium ion and glutamate to glutamine)-introduced HepG2 (HepG2-GS-CYP3A4), was established. Its usefulness in a large-scale culture with a circulatory bioreactor in vitro and in dog models of ischemic hepatic failure with acute diazepam (DZP, a substrate of CYP3A4) overdosage was further examined. HepG2-GS-CYP3A4 expressed about 9 times larger amounts of CYP3A4 protein than a control. After incubation with HepG2-GS-3A4 cells in a circulatory bioreactor for 24 h, ammonia and DZP concentrations in the culture medium significantly decreased by about 40%. Furthermore, this system improved the survival time and decreased serum concentrations of DZP, ammonia, and transaminase in dogs with ischemic hepatic failure plus acute DZP overdosage. The mean survival time with bioreactor with HepG2-GS-3A4 was 42.7 +/- 3.6 h, which was significantly longer than that without reactor, with reactor (no cells), and with HepG2-GS (23.4 +/- 2.8, 22.1 +/- 2.4, and 31 +/- 3.7 h, respectively). Therefore, it is concluded that this bioartificial liver could be a good tool for the treatment of dogs with hepatic failure and that it could potentially be a bridging procedure to liver transplantation.
  • Naohiro Sata, Masaru Koizumi, Munetoshi Tsukahara, Kouji Yoshizawa, Katsumi Kurihara, Hideo Nagai
    Journal of hepato-biliary-pancreatic surgery 12 (1) 71 - 5 0944-1166 2005 [Refereed][Not invited]
     
    The treatment of intraductal papillary mucinous tumors (IPMT) of the pancreas is still controversial. In this report we describe a single-branch resection of the pancreas (SBRP), which is a new method for the removal of branch-type IPMT of the head of the pancreas. A multilobular cystic lesion (50 x 40 mm) in the head of the pancreas was incidentally detected in an asymptomatic 40-year-old man who underwent a routine ultrasound examination. The tumor was carefully removed along the border of the cyst and the normal parenchyma, with complete preservation of the main pancreatic duct and the common bile duct. A pancreatic fistula developed during the postoperative period, but was well-controlled by endoscopic naso-pancreatic drainage. SBRP is a technically feasible procedure and this operation represents a minimally invasive alternative to any other segmental resection of the pancreas.
  • Naohiro Sata, Munetoshi Tsukahara, Masaru Koizumi, Koji Yoshizawa, Katsumi Kurihara, Hideo Nagai, Tsutomu Someya, Ken Saito
    World journal of surgical oncology 2 28 - 28 1477-7819 2004/08 [Refereed][Not invited]
     
    BACKGROUND: Small-cell neuroendocrine carcinoma in the duodenum is an extremely rare neoplasm with poor prognosis. CASE PRESENTATION: A 57-year-old man presented with sudden onset gastrointestinal bleeding and fainting attacks. Duodenoscopy and hypotonic duodenography revealed a 3 x 3 cm protruding tumor with ulcerations situated opposite the ampulla of Vater in the second part of the duodenum. Local excision of the tumor was performed, followed by adjuvant chemotherapy with 5-fluoro uracil and leucovorin. Examination of the tumor by immunohistochemistry and electron microscopy indicated it to be neuroendocrine in nature, expressing synaptophysin and AE1/AE3, and containing dense core granules. The patient showed no sign of recurrence and has been disease-free for more than 48 months after surgery. CONCLUSIONS: Most cases of small-cell neuroendocrine carcinoma in the duodenum show rapid progression of the disease, and even radical surgery with or without chemotherapy do not prevent death. We report a rare subtype of small-cell neuroendocrine carcinoma. This subtype appears to have a much better prognosis, and may be amenable to local excision, if the lesion is away from the ampulla of Vater.
  • Jianfeng Bai, Naohiro Sata, Hideo Nagai, Tomoaki Wada, Koji Yoshida, Hiroyuki Mano, Fumihiro Sata, Reiko Kishi
    Pancreas 29 (2) 93 - 8 0885-3177 2004/08 [Refereed][Not invited]
     
    OBJECTIVES: To investigate the effect of genistein on gene expression in Panc 1 cells using microarray technology. METHODS: Panc 1 cells were treated with 10 micromol/L genistein or DMSO (vehicle control) for 0, 1, 3, 6, or 12 hours. Total RNA from each sample was isolated, and biotin-labeled probes were hybridized to the human genome U133A chip, after which the chip was washed and scanned. Data were analyzed using DMT software (Affymetrix). For genes that showed large changes in expression due to genistein, these changes were confirmed using real-time PCR assays. RESULTS: Two independent microarray experiments showed that genistein significantly changed the expression of 47 genes: up-regulating of egr-1 and IL-8 and down-regulating of EGF-R AKT2, CYP1B1, NELL2, SCD, DNA ligase III, Rad as well as 18s and 28s rRNA and others. These alterations in expression were confirmed using real-time PCR, although the increase in change was not exactly the same in the 2 assays. CONCLUSIONS: Our data suggest the reported apparent ability of genistein to inhibit carcinogenesis may involve a number of pathways. The most obvious target is the EGF-R signaling pathway since the expression of 5 genes related to this pathway was reduced (EGFR, egr-1, AKT2, CYP1B1, and NELL2). Genistein may also act by disabling cancer cell self-protection by inhibiting expression of AKT2, CYP1B1, and DNA ligase III. Furthermore, genistein may inhibit car-cinogenesis by inhibiting expression of SCD. Finally, our data support findings indicating that genistein inhibits rRNA formation, which is an important mechanism by which genistein regulates tumor cell growth.
  • M Hyodo, H Nagai, N Sata, T Ishitsuka, K Kurihara, K Yoshizawa, K Saitoh
    HEPATO-GASTROENTEROLOGY 50 (53) 1687 - 1688 0172-6390 2003/09 [Refereed][Not invited]
     
    A 43-year-old Japanese man had an increasing level of serum CEA pointed out, by annual-physical checkups. No abnormal findings were detected,in the lungs or gastrointestinal tract. The only pathological lesions were a 1.5-cm-sized nodule in the pancreatic tail and a 5-cm-sized thyroid tumor. The thyroid tumor was shown to be Medullary carcinoma by aspiration cytology He underwent total thyroidectomy with extensive lymph node-dissection., After thyroid surgery,,the patient received distal pancreatectomy 2 weeks later. Pathological examination revealed the pancreatic tumor to be a metastasis of thyroid medullary carcinoma. The patient is alive and well without recurrence 5 years after thyroidectomy and pancreatectomy. The serum levels of CEA and calcitonin remain within normal limits. Thus, the patient seems to have had a solitary metastatic tumor from thyroid medullary cancer.
  • Naohiro Sata, Masaru Koizumi, Munetoshi Tsukahara, Koji Yoshizawa, Katsumi Kurihara, Hideo Nagai
    Annals of Cancer Research and Therapy 11 (1-2) 231 - 242 1344-6835 2003 [Refereed][Not invited]
     
    Pancreatic cancer has a dismal prognosis because most lesions are unresectable where as adjuvant and palliative chemotherapy exhibits poor results. Six patients with locally unresectable pancreatic cancer were treated with mitomycin-C (MMC) 8mg/m2 on day 1 and 5-FU 375mg/m2 and LV 20mg/m2 on days 1 to 5. Treatment cycles were repeated every four weeks if the patient's general condition permitted. All patients had measurable, histologically proven adenocarcinoma and had not undergone prior chemotherapy. Three patients underwent hepaticojejunostomy whilst choledochal stents were endoscopically inserted in two patients. No significant side effects of grade 3 or 4 were observed. Five of six patients who received an average of 5 treatment cycles died of their disease with a medial survival of 8.9 months. The remaining patient received 12 treatment cycles and 8 additional treatments without mitomycin-C and exhibited a complete remission for 36 months. Our data suggest that MMC plus 5-FU and leucovorin is a tolerable regimen and has promising effects. Further prospective studies are needed. Copyright © 2003 By PJD Publications Limited.
  • Kenji Takegami, Naohiro Sata, Yoneei Kawaguchi, Yoshiro Kubota
    Surgery today 32 (2) 129 - 33 0941-1291 2002 [Refereed][Not invited]
     
    PURPOSE: This study was performed to evaluate the operative conditions for an abdominal wall-lifting laparoscopic cholecystectomy (ALLC) using a new preoperative grading system. METHODS: One hundred forty-five patients who underwent a cholecystectomy for cholecystolithiasis from January 1997 to December 1999 were retrospectively analyzed. Allotting 0-5 points for coexisting cholecystitis, past history, previous upper abdominal laparotomy, preoperative drainage, location of the stones, and body mass index, the total combined score was defined as the predictive score. The cases were graded into four risk groups according to the predictive score. The postoperative score, which evaluated the actual conditions of ALLC, was defined by allotting 0-8 points to operative factors: operation time, blood loss, additional trocars and procedures, conversion to open surgery, and postoperative complications. RESULTS: Ten cases (6.9%) were converted to open surgery and three cases (2.1%) had minor postoperative complications. The conversion rate for each risk group was 0% (minimum-risk group), 5.4% (low-risk group), 10.7% (intermediate-risk group), and 17.9% (high-risk group). The mean operation time was 63.0, 87.5, 89.0, and 120.2 min. The mean postoperative score was 1.08, 2.81, 3.96, and 6.36, and showed a respectively strong correlation with the predictive score (correlation coefficient: 0.997). CONCLUSIONS: Our preoperative grading system using the predictive score was found to be a reliable and feasible method for predicting the actual operative conditions for ALLC.
  • K Yoshizawa, H Nagai, K Kurihara, N Sata, T Kawai, K Saito
    HEPATO-GASTROENTEROLOGY 48 (40) 1153 - 1156 0172-6390 2001/07 [Refereed][Not invited]
     
    Background/Aims: Pancreatic cancer remains one of the most formidable tumors defying early detection and effective treatment. Long-term survivors, however, do exist after resection. We investigated the clinicopathologic features of patients with pancreatic cancer who survived more than 5 years to draw out some suggestions concerning the indication of surgical treatment. Methodology: We studied the clinicopathologic features of 13 patients with pancreatic cancer who survived more than 5 years after resection. We reviewed their clinical records to investigate preoperative symptoms, serum tumor markers, operative findings, postoperative adjuvant therapy, and modes of recurrence and survival periods. Information on the location, size, histology and spread of the primary tumors were mainly obtained from pathology reports. Results: Histologic types of the long survivors included ductal adenocarcinoma of common type in 4 patients, mucinous noncystic adenocarcinoma in 2, intraductal papillary-mucinous carcinoma (invasive) in 4, undifferentiated carcinoma in 1, endocrine tumor (islet cell carcinoma) in 1 and acinar cell carcinoma in 1. All 4 cases of ductal adenocarcinoma of the common type showed a moderate invasion either to the retroperitoneum, the portal vein or the duodenum. Two patients with mucinous noncystic carcinoma attained a long survival despite extensive invasion of the pancreatic stroma, although one died of peritoneal carcinomatosis. Two of 4 patients with intraductal papillary-mucinous cancer (invasive) died of peritoneal dissemination 6 and 11 years after resection, respectively. Three patients with cancer of other special histologic types, i.e., undifferentiated, well-differentiated endocrine carcinoma and acinar cell carcinoma, showed invasion of the portal vein and splenic artery, involvement of the retroperitoneum and a metastatic tumor in the liver, respectively. Conclusions: Whereas special histologic types including ductal variants tended to predispose to long-term survival, ductal adenocarcinoma of the common type had some chance of long survival even with invasion of the surrounding tissues.
  • Noriaki Futakawa, Wataru Kimura, Seiichi Yamagata, Bin Zhao, Han Ilsoo, Tomomi Inoue, Naohiro Sata, Yoneei Kawaguchi, Yoshiro Kubota, Tetsuichiro Muto
    Journal of Hepato-Biliary-Pancreatic Surgery 7 (1) 63 - 71 0944-1166 2000 [Refereed][Not invited]
     
    The early diagnosis of pancreatic carcinoma is essential for increasing patient survival rates. In this study, 52 patients with suspected pancreatic diseases were examined to investigate the value of K-ras codon 12 point mutation, levels of carcinoembryonic antigen (CEA) and carbohydrate antigen (CA19-9), and cytology of pancreatic juice in the diagnosis of pancreatic carcinoma. Pancreatic juice was taken without secretin stimulation. K-ras mutation was detected by enriched polymerase chain reaction (PCR) restriction fragment length polymorphism (RFLP). K-ras mutation in pancreatic juice was more frequent in carcinoma than in benign diseases (P = 0.0448). The positive predictive value of K-ras mutation for the diagnosis of neoplastic disease was 83%. The CEA level in pancreatic juice in carcinoma was significantly greater than that in benign disease (P < 0.0001). When the cutoff level of CEA was set at 50ng/ml, its accuracy for the diagnosis of carcinoma was 85%. A multivariate analysis showed that K-ras mutation and CEA level in pancreatic juice, as well as serum CA19-9 level and age of the patient were independent variables for the diagnosis of carcinoma, and the accuracy of diagnosis by this analysis was increased to 90%. In conclusion, both K-ras mutation and CEA level in pancreatic juice may be valuable for the diagnosis of carcinoma. Better discrimination was possible with a multivariate analysis.
  • C Niederau, R Luthen, H Klonowski-Stumpe, R Schreiber, Soika, I, N Sata, H Bing, D Haussinger
    HEPATO-GASTROENTEROLOGY 46 (29) 2723 - 2730 0172-6390 1999/09 [Refereed][Not invited]
     
    BACKGROUND/AIMS: A large, sustained increase in acinar [Ca2+](i) may play a key role in the pathogenesis of acute pancreatitis. Many mechanisms which lead to cell damage in vitro and pancreatitis in, vivo, such as free radicals or supraphysiological cerulein concentrations, cause a rapid increase in [Ca2+](i) in pancreatic acinar cells. Little is known about why [Ca2+](i) increases in some instances stimulate secretion and in other instances initiate cell death. So far, [Ca2+](i) increases were thought to represent physiological signals when they occurred as oscillations at the single cell level. METHODOLOGY: This paper reviews recent literature and our own original research about the role of calcium in the function of pancreatic acinar cells and the development of pancreatitis. RESULTS: Recent studies showed that exposure of acinar cells' to free radicals not only caused a bulk increase in [Ca2+](i) but also resulted in calcium oscillations which had a lower frequency than, but similar amplitude to oscillations occurring after physiological stimuli. The absolute increase in [Ca2+](i) did not definitely determine the cellular response. Instead, the duration of [Ca2+](i) increase may have been more important. In contrast to previous belief of a direct relationship between [Ca2+](i) oscillations and exocytosis, recent results show that radicals can induce [Ca2+](i) oscillations which do not exert exocytosis but inhibit the secretory response to physiological stimuli. Further experiments showed that the [Ca2+](i) release caused by radicals originates from thapsigargin-insensitive, ryanodine-sensitive stores. CONCLUSIONS: The origin and duration of [Ca2+](i) increases rather than their extent or oscillatory nature, determine whether the cell will secrete or die. An abnormal [Ca2+](i) increase can trigger trypsin activation, acinar cell damage and acute pancreatitis. This hypothesis is supported by studies which show that calcium chelators inhibit radical-induced trypsin activation as well as cell necrosis and apoptosis. Thus, an inhibition of pathological [Ca2+](i) release may have a therapeutic potential.
  • N Sata, Y Kawaguchi, Y Komuro, Y Kubota, S Saito, N Futakawa
    GASTROENTEROLOGY 114 (4) A539 - A539 0016-5085 1998/04 [Not refereed][Not invited]
  • H Klonowski-Stumpe, R Luthen, B Han, N Sata, D Haussinger, C Niederau
    PANCREAS 16 (1) 96 - 101 0885-3177 1998/01 [Refereed][Not invited]
     
    Activation of trypsinogen is thought to trigger the autodigestive process in acute pancreatitis. The lysosomal enzyme cathepsin B was suggested to cause the activation of trypsinogen because it is known that cathepsin B is able to activate trypsinogen in special circumstances and that lysosomal and digestive enzymes are colocalized within intracellular vacuoles in the early stage of pancreatitis, As yet this hypothesis has been difficult to prove because activated trypsin is difficult to quantify in pancreatitis by conventional enzymatic measurements. We therefore employed an ELISA for trypsin activating peptide (TAP), which is a small peptide cleaved during the activation of trypsinogen and can be determined reliably. Supraphysiological concentrations of cerulein (1 nM-1 mu M) resulted in a marked increase in TAP in freshly isolated pancreatic acinar cells, indicating activation of trypsinogen. This activation as determined by the TAP increase was significantly reduced by the serine protease inhibitor Fut-175 but not by the cathepsin B inhibitors E-64 and NCO-700. The concentrations of NCO-700 and E-64 abolished the cathepsin B activity of pancreatic acinar cells but did not significantly reduce the trypsin activity (after enterokinase preincubation); correspondingly the concentrations of Fut-175 used abolished the trypsin activity but did not reduce the cathepsin B activity. The results indicate that an autoactivation of trypsin rather than an activation of trypsinogen by cathepsin B triggers trypsin activation by supramaximal cerulein concentrations.
  • N Sata, H KlonowskiStumpe, B Han, D Haussinger, C Niederau
    PANCREAS 15 (3) 278 - 284 0885-3177 1997/10 [Not refereed][Not invited]
     
    Peroxynitrite (0.5-50 mu M) induced does-dependent cytotoxic effects in rat pancreatic acinar AR4-2J cells. Glutathione (2 mM) and ebselen (10 mu M) partially reduced the cytotoxicity caused by 1-10 mu M concentrations of peroxynitrite. Higher concentrations (10-50 mu M) of peroxynitrite induced DNA smear suggestive of necrosis, while lower concentrations (2-5 mu M) induced DNA fragmentations suggestive of apoptosis. The effects of peroxynitrite on [Ca2+](i) showed a similar dose dependency. Peroxynitrite concentrations >10 mu M rapidly increased [Ca2+](i) in a dose-dependent manner, while concentrations <5 mu M did not affect [Ca2+](i). In contrast, the presentation of wild-type P53 was accelerated at lower concentrations of peroxynitrite (less than or equal to 10 mu M) but not at higher concentrations (50 mu M). The present study suggests that peroxynitrite at lower concentrations (2-5 mu M) induces wildtype P53 and apoptosis, which is potentially a protective response toward the DNA damage caused by peroxynitrite. On the other hand, higher concentrations of peroxynitrite (10-50 mu M) rapidly increase [Ca2+](i) and eventually induce necrosis.
  • N Sata, H KlonowskiStumpe, B Han, D Haussinger, C Niederau
    FREE RADICAL BIOLOGY AND MEDICINE 23 (6) 844 - 850 0891-5849 1997 [Not refereed][Not invited]
     
    This study evaluated the action of menadione on cell proliferation and integrity of the rot pancreatic acinar cell line, AR4-2J. Menadione at 1-20 mu M dose-and time-dependently inhibited cell proliferation of AR4-2J cells. In contrast, a high concentration of menadione (100 mu M) caused rapid cell death (> 90% of cells took up trypan blue within 4-h). While the high concentration of menadione (100 mu M) induced DNA smear in electrophoresis indicative of necrosis, lower concentrations (10-20 mu M) induced a DNA ladder indicative of apoptosis, Similar results were obtained using a DNA fragmentation ELISA. Glutathione (1 mM), the calcium chelator EGTA (500 mu M), and the cystein protease inhibitor NCO-700 (5 mM) partly inhibited the effect of 1-10 mu M menadione on cell proliferation and DNA fragmentation. Menadione at 1-20 mu M induced wild-type P53, whereas the 100 mu M menadione had a minor effect on wild-type P53. It is concluded that menadione induced necrosis at high concentrations and apoptosis at low concentrations in AR4-2J cells. Apoptosis induced by lower concentrations of menadione may be mediated by wild-type P53, intracellular calcium, and mechanisms which decrease the intracellular concentration of reduced glutathione. (C) 1997 Elsevier Science Inc.
  • H Shinkai, W Kimura, N Sata, T Muto, H Nagai
    HEPATO-GASTROENTEROLOGY 43 (11) 1370 - 1376 0172-6390 1996/09 [Refereed][Not invited]
     
    A 55-year-old man with gallbladder cancer was surgically treated in our hospital in July 1988. The tumor was about 8 cm in diameter, replaced the entire gallbladder, and invaded the liver and the hepatoduodenal ligament. In addition, extensive tumor metastasis to lymph nodes, including those of the para-aortic area was noted (Stage IV). Extended cholecystectomy with resection of the liver and lymph node dissection were performed. Although all of the macroscopic tumors were removed surgically, toe believed that the tumor would recur in. the near future, since all of the excised para-aortic lymph nodes were involved by carcinoma histologically. After surgery, the patient received 5'-deoxy-5-fluorouridine (5'-DFUR) orally at a dose of 600mg per day. In December 1993, more than 5 years after the primary operation, cancer recurrence in para-aortic lymph nodes was demonstrated by computed tomography (CT). In June 1994, the patient underwent a second operation for treatment of recurrent tumor. The lymph nodes firmly adhered to both the aorta and left renal vein, and could not be removed. Since August 1994, he has received external radiation therapy, and there has been no further enlargement of the nodes. This is the first reported case of gallbladder cancer with para-aortic lymph node metastasis who survived more than, seven years after the primary extended radical operation with cholecystectomy, resection of the liver, and extended lymph node dissection.
  • N Sata, H Klonowski, B Han, D Haussinger, C Niederau
    GASTROENTEROLOGY 110 (4) A428 - A428 0016-5085 1996/04 [Not refereed][Not invited]
  • N Sata, W Kimura, T Muto, C Mineo
    JOURNAL OF GASTROENTEROLOGY 31 (1) 94 - 99 0944-1174 1996/02 [Not refereed][Not invited]
     
    Exocrine function was studied in anesthetized rats that had received two specific doses of caerulein (maximal stimulation and supramaximal stimulation). Male Wistar rats (body weight, 200-250 g) were divided into three groups: the control group (4-h saline infusion), the maximal stimulation group (0.25 mu g/kg per h caerulein for 4h), and the caerulein pancreatitis group (10 mu g/kg per h for 4h). Histologically, interstitial edema and cytoplasmic vacuolization were observed only in the caerulein pancreatitis group, with no abnormal findings in the other groups. The volume of pancreatic juice was significantly increased in both the maximal stimulation group and the caerulein pancreatitis group. The protein ouput and the amylase output in the 1st h of caerulein infusion were also significantly increased, to 459% and 338% in the maximal stimulation group, and to 925% and 1430% respectively, in the caerulein pancreatitis compared to the baseline values. We also found that the pancreatic juice of the caerulein pancreatitis group contained precipitated protein, and high trypsin activity, and protein degradation was confirmed by electrophoresis. These findings were not observed in the other groups. These results strongly suggest that hypersecretion and the appearance of trypsin activity in pancreatic juice plays an important role in the induction of histological changes in this pancreatitis model in anesthetized rats.
  • N SATA, W KIMURA, T KANAZAWA, T MUTO
    SURGERY TODAY-THE JAPANESE JOURNAL OF SURGERY 25 (7) 640 - 642 0941-1291 1995 [Not refereed][Not invited]
     
    We report herein a rare case of malignant insulinoma which recurred as multiple liver metastasis 8 years after the initial resection, The patient was a 51-year-old Japanese man who originally presented in 1985 at the age of 43 years suffering from general malaise and syncope, The initial surgery in 1985 involved complete enucleation of a 15 X 13mm insulinoma located in the uncus of the pancreas, Histopathologically, the tumor was diagnosed as a benign adenoma (insulinoma) which was immunohistochemically stained with only the anti-insulin monoclonal antibody, Macroscopically, there were no signs of either invasion or metastasis. During the subsequent 7 years, he did not show any symptoms or significant abnormality in laboratory data, However, in 1993, the patient again experienced syncope with hypoglycemia and hyperinsulinemia. Ultrasonography revealed multiple echogenic lesions in the liver and a second laparotomy confirmed multiple hepatic metastases from insulinoma, the histopathological findings of which were similar to those of the primary tumor from 8 gears before, The patient is currently being treated with streptozotocin and 5-fluorouracil via a catheter in the hepatic artery.
  • Wataru Kimura, Naohiro Sata, Hiroshi Nakayama, Tetsuichiro Muto, Nobuyuki Matsuhashi, Kentaro Sugano, Yutaka Atomi
    Journal of Gastroenterology 29 (6) 786 - 791 0944-1174 1994/12 [Refereed][Not invited]
     
    Two cases of pancreatic cancer accompanied by pseudocyst are reported. Case 1 was a 60-year-old man who was admitted to our hospital complaining of left lower abdominal discomfort. A cystic lesion, about 3 cm in diameter, was found in the pancreatic tail by ultrasonography (US) and computed tomography (CT). No signs of chronic pancreatitis were found. At operation, an elastic, hard, white tumor, about 1 cm in diameter, was felt adjacent to the cystic lesion on the duodenal side. Histologically, this tumor was a duct cell carcinoma with an adjacent pseudocyst upstream of the pancreas. Case 2 was a 57-year-old man who complained of back pain and loss of body weight. US and CT examination revealed a cystic lesion, 11×7 cm in size, in the tail of the pancreas. Histological examination of the resected speciment revealed both a duct cell carcinoma, 3 cm in size, in the body of the pancreas and a pseudocyst, 9 cm in size. Pseudocysts accompanying carcinoma are thought to develop from obstruction of the pancreatic duct by the carcinoma, followed by intraductal high pressure and disruption of ductules upstream of the pancreas. Thus, we should pay careful attention to pseudocyst of the pancreas, especially when signs of diffuse chronic inflammation cannot be found, to help identify duct cell carcinoma in the early stage. Further detailed examinations of the cyst fluid or pancreatic juice, such as cytology, tumor marker determinations, or establishment of K-ras codon 12 mutation, are needed. © 1994 Springer-Verlag.
  • Naohiro Sata, Yutaka Atomi, Wataru Kimura, Akira Kuroda, Tetsuichiro Muto, Chieko Mineo
    International Journal of Pancreatology 15 (2) 119 - 127 1537-3649 1994/04 [Refereed][Not invited]
     
    The intracellular distribution and action of a new synthetic protease inhibitor, E3123, were studied in cerulein-induced acute pancreatitis in rats. Acute pancreatitis was induced by a 4-h iv infusion of a supramaximal dose of cerulein, and was treated by prophylactic (pretreatment) or therapeutic (posttreatment) continuous administration of E3123. Pancreatic edema and hyperamylasemia were ameriolated only by prophylactic treatment. A subcellular fractionation study showed that the activities of cathepsin-B and trypsin in the zymogen granule-enriched fraction of the cerulein-pancreatitis group were remarkably increased. Both prophylactic and therapeutic treatment significantly prevented the elevation of these enzyme activities. These effects were accompanied by amelioration of pancreatic histopathological features, including intracellular vacuolization and fat necrosis. A microscopic autoradiographic study using2H-labeled E3123 showed diffuse intracellular distribution of E3123, and the radioactivity of2H-E3123 in the posttreatment group was three times greater than that in the pretreatment group. This study provides the first experimental evidence that, even when administered therapeutically, exogenous protease inhibitors are transported into pancreatic acinar cells, thereby reducing the seventy of early intracellular alterations in cerulein-induced acute pancreatitis. © 1994 Humana Press Inc.
  • N SATA, Y ATOMI, W KIMURA, A KURODA, T MUTO, C MINEO
    INTERNATIONAL JOURNAL OF PANCREATOLOGY 15 (2) 119 - 127 0169-4197 1994/04 [Not refereed][Not invited]
     
    The intracellular distribution and action of a new synthetic protease inhibitor, E3123, were studied in cerulein-induced acute pancreatitis in rats. Acute pancreatitis was induced by a 4-h iv infusion of a supramaximal dose of cerulein, and was treated by prophylactic (pretreatment) or therapeutic (posttreatment) continuous administration of E3123. Pancreatic edema and hyperamylasemia were ameriolated only by prophylactic treatment. A subcellular fractionation study showed that the activities of cathepsin-B and trypsin in the zymogen granule-enriched fraction of the cerulein-pancreatitis group were remarkably increased. Both prophylactic and therapeutic treatment significantly prevented the elevation of these enzyme activities. These effects were accompanied by amelioration of pancreatic histopathological features, including intracellular vacuolization and fat necrosis. A microscopic autoradiographic study using H-3-labeled E3 123 showed diffuse intracellular distribution of E3 123, and the radioactivity of H-3-E3 123 in the posttreatment group was three times greater than that in the pretreatment group. This study provides the first experimental evidence that, even when administered therapeutically, exogenous protease inhibitors are transported into pancreatic acinar cells, thereby reducing the severity of early intracellular alterations in cerulein-induced acute pancreatitis.

Conference Activities & Talks

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    金丸 理人, 山口 博紀, 齋藤 心, 倉科 憲太郎, 大澤 英之, 高橋 和也, 金子 勇貴, 細谷 好則, 佐田 尚宏, 北山 丈二
    日本消化器外科学会総会  2021/07  (一社)日本消化器外科学会
  • Flow cytometryを用いた胃癌患者腹腔内遊離癌細胞・免疫細胞の解析
    高橋 和也, 大澤 英之, 金丸 理人, 倉科 憲太郎, 齋藤 心, 山口 博紀, 細谷 好則, 北山 丈二, 佐田 尚宏
    日本消化器外科学会総会  2021/07  (一社)日本消化器外科学会
  • 外科系医師はどのようにして医学教育のキャリアを形成していくのか? シミュレーション教育未経験の外科医が始める医学教育のキャリア形成
    川平 洋, 遠藤 和洋, 鈴木 義彦, 前田 佳孝, 兼田 裕司, 淺田 義和, アラン・レフォー, 佐田 尚宏
    医学教育  2021/07  (一社)日本医学教育学会
  • 外科医による起業-医工連携・産学連携- 外科医を取り巻く職場ニーズから中小企業の事業創出に繋がった産学連携事業の報告
    川平 洋, 井上 賢之, 篠原 翔一, 兼田 裕司, 千葉 蒔七, 窪木 大悟, 太田 学, 松本 志郎, 山口 博紀, 佐久間 康成, 堀江 久永, 細谷 好則, 味村 俊樹, 北山 丈二, Lefor Alan K., 中村 亮一, 下村 義弘, 佐田 尚宏
    日本外科学会定期学術集会抄録集  2021/04  (一社)日本外科学会
  • 直腸原発Goblet cell carcinoidの1例
    小林 龍ノ介, 太田 学, 本間 祐子, 熊谷 祐子, 東條 峰之, 太白 健一, 佐田友 藍, 直井 大志, 井上 賢之, 鯉沼 広治, 笹沼 英紀, 山口 博紀, 佐久間 康成, 川平 洋, 堀江 久永, 細谷 好則, 味村 俊樹, 北山 丈二, 佐田 尚宏
    日本消化器病学会関東支部例会プログラム・抄録集  2020/12  日本消化器病学会-関東支部
  • 遠隔診療と遠隔教育 学習管理・ウェブ会議システム併用による遠隔型外科臨床実習の実施報告
    川平 洋, 前田 佳孝, 淺田 義和, 鈴木 義彦, 山口 博紀, 佐久間 康成, 堀江 久永, 細谷 好則, 味村 俊樹, 北山 丈二, 佐田 尚宏
    日本コンピュータ外科学会誌  2020/11  (一社)日本コンピュータ外科学会
  • 大腸癌免疫微小環境に対するメトホルミンの影響
    齋藤 晶, 大澤 英之, 金子 勇貴, 風當 ゆりえ, 田村 昂平, 高橋 和也, 木村 有希, 東條 峰之, 熊谷 祐子, 佐田 尚宏, 北山 丈二
    日本癌治療学会学術集会抄録集  2020/10  (一社)日本癌治療学会
  • 骨髄間葉系幹細胞由来エクソソーム内包miR-29bは腹膜中皮細胞への影響を介して胃癌腹膜播種を抑止する
    木村 有希, 大澤 英之, 齋藤 晶, 高橋 和也, 東條 峰之, 熊谷 祐子, 佐田 尚宏, 北山 丈二
    日本癌学会総会記事  2020/10  (一社)日本癌学会
  • 腫瘍免疫微小環境に対するメトホルミンの効果
    齋藤 晶, 大澤 英之, 高橋 和也, 木村 有希, 東條 峰之, 熊谷 祐子, 佐田 尚宏, 北山 丈二
    日本癌学会総会記事  2020/10  (一社)日本癌学会
  • マウス胃癌腹膜播種モデルにおける抗PD-1抗体の効果と腹腔内免疫細胞の動態について
    熊谷 祐子, 宮戸 秀世, 大澤 英之, 佐久間 康成, 堀江 久永, 細谷 好則, 佐田 尚宏, 北山 丈二
    日本癌学会総会記事  2020/10  (一社)日本癌学会
  • 大腸癌細胞株LuM1肺転移モデルにおけるMetformin併用放射線治療
    東條 峰之, 津久井 秀則, 齋藤 晶, 高橋 和也, 木村 有希, 熊谷 祐子, 宮戸 秀世, 大澤 英之, 鯉沼 広治, 堀江 久永, 佐田 尚宏, 北山 丈二
    日本癌学会総会記事  2020/10  (一社)日本癌学会
  • Neutrophil extracellular trapsは胃癌細胞の浸潤能を促進する
    高橋 和也, 大澤 英之, 木村 有希, 齋藤 晶, 東條 峰之, 熊谷 祐子, 北山 丈二, 佐田 尚宏
    日本癌学会総会記事  2020/10  (一社)日本癌学会
  • 新生児期発症のメチルマロン酸血症に対する生体肝移植の治療成績
    宮原 豪, 眞田 幸弘, 大豆生田 尚彦, 片野 匠, 平田 雄大, 山田 直也, 岡田 憲樹, 大西 康晴, 佐久間 康成, 佐田 尚宏
    移植  2020/10  (一社)日本移植学会
  • 当院における脳死分割肝移植の経験
    大西 康晴, 眞田 幸弘, 佐久間 康成, 岡田 憲樹, 山田 直也, 平田 雄大, 宮原 豪, 片野 匠, 大豆生田 尚彦, 吉田 幸世, 水田 耕一, 佐田 尚宏
    移植  2020/10  (一社)日本移植学会
  • 小児肝疾患の脳死肝移植登録における現状と問題点
    眞田 幸弘, 佐久間 康成, 大西 康晴, 岡田 憲樹, 山田 直也, 平田 雄大, 宮原 豪, 片野 匠, 大豆生田 尚彦, 吉田 幸世, 佐田 尚宏
    移植  2020/10  (一社)日本移植学会
  • 当院における小児生体肝移植後PTLDの現状と対策
    平田 雄大, 眞田 幸弘, 大西 康晴, 岡田 憲樹, 宮原 豪, 片野 匠, 大豆生田 尚彦, 佐久間 康成, 佐田 尚宏
    移植  2020/10  (一社)日本移植学会
  • 当科におけるエリブリン投与患者の末梢好中球リンパ球比と予後の相関についての検討
    西田 紗季, 原尾 美智子, 扇原 香澄, 櫻木 雅子, 北山 丈二, 佐田 尚宏
    日本乳癌学会総会プログラム抄録集  2020/10  (一社)日本乳癌学会
  • 術後1ヵ月で再発したG-CSF産生を疑うMyoepithelial carcinomaの一例
    扇原 香澄, 原尾 美智子, 櫻木 雅子, 西田 紗季, 北山 丈二, 佐田 尚宏
    日本乳癌学会総会プログラム抄録集  2020/10  (一社)日本乳癌学会
  • 働き方改革 ワーク・ライフ・バランスを意識してのりこえる 短時間業務者との連携プレー
    櫻木 雅子, 原尾 美智子, 扇原 香澄, 相良 由佳, 西田 紗季, 芝 聡美, 佐々木 裕美子, 宮崎 千絵子, 大澤 英之, 竹原 めぐみ, 塩澤 幹雄, 水沼 洋文, 北山 丈二, 佐田 尚宏
    日本乳癌学会総会プログラム抄録集  2020/10  (一社)日本乳癌学会
  • 当院におけるBRCAnalysisの現状と今後の課題
    原尾 美智子, 扇原 香澄, 西田 紗季, 櫻木 雅子, 北山 丈二, 佐田 尚宏
    日本乳癌学会総会プログラム抄録集  2020/10  (一社)日本乳癌学会
  • 回腸原発悪性黒色腫の一例
    篠原 翔一, 直井 大志, 太田 学, 本間 祐子, 佐田 友藍, 巷野 佳彦, 鯉沼 広治, 山口 博紀, 佐久間 康成, 川平 洋, 堀江 久永, 細谷 好則, 味村 俊樹, 北山 丈二, 佐田 尚宏
    日本臨床外科学会雑誌  2020/10  日本臨床外科学会
  • 術前CT検査による3D血管構築が腹腔鏡手術に有用であった腸回転異常に伴う上行結腸癌の1例
    直井 大志, 鯉沼 広治, 太田 学, 本間 祐子, 佐田 友藍, 巷野 佳彦, 山口 博紀, 佐久間 康成, 川平 洋, 堀江 久永, 細谷 好則, 味村 俊樹, 北山 丈二, 佐田 尚宏
    日本臨床外科学会雑誌  2020/10  日本臨床外科学会
  • 低位前方切除後症候群診療における進歩と課題 低位前方切除後症候群に対する経肛門的洗腸療法の有用性に関する検討
    本間 祐子, 味村 俊樹, 村橋 賢, 太田 学, 太白 健一, 熊谷 祐子, 東條 峰之, 佐田友 藍, 直井 大志, 鯉沼 広治, 堀江 久永, 北山 丈二, 佐田 尚宏
    日本大腸肛門病学会雑誌  2020/09  (一社)日本大腸肛門病学会
  • 大腸憩室出血の診断と治療 当院における大腸憩室出血に対する外科的治療の現状
    鯉沼 広治, 堀江 久永, 太田 学, 直井 大志, 佐田友 藍, 本間 祐子, 太白 健一, 井上 賢之, 伊藤 誉, 田原 真紀子, 味村 俊樹, 佐田 尚宏, 森川 昇玲, 林 芳和, 砂田 圭二郎, 山本 博徳
    日本大腸肛門病学会雑誌  2020/09  (一社)日本大腸肛門病学会
  • 眞田 幸弘, 佐久間 康成, 大西 康晴, 岡田 憲樹, 平田 雄大, 佐田 尚宏
    日本小児栄養消化器肝臓学会雑誌  2020/09  (一社)日本小児栄養消化器肝臓学会
  • 平田 雄大, 眞田 幸弘, 大西 康晴, 岡田 憲樹, 佐久間 康成, 佐田 尚宏
    日本小児栄養消化器肝臓学会雑誌  2020/09  (一社)日本小児栄養消化器肝臓学会
  • Growing teratoma syndromeの診断で外科的切除を行った1例
    篠田 祐之, 吉田 淳, 篠原 翔一, 窪木 大悟, 宮戸 秀世, 森嶋 計, 遠藤 和洋, 笹沼 英紀, 佐久間 康成, 堀江 久永, 細谷 好則, 北山 丈二, 佐田 尚宏
    日本臨床外科学会雑誌  2020/09  日本臨床外科学会
  • 虫垂重積症を来した虫垂子宮内膜症の1例
    宮原 悠三, 伊藤 誉, 下地 信, 東 博, 佐田友 藍, 巷野 佳彦, 田原 真紀子, 鯉沼 広治, 堀江 久永, 佐田 尚宏
    Gastroenterological Endoscopy  2020/09  (一社)日本消化器内視鏡学会
  • 眞田 幸弘, 佐久間 康成, 大西 康晴, 岡田 憲樹, 山田 直也, 平田 雄大, 宮原 豪, 片野 匠, 大豆生田 尚彦, 佐田 尚宏
    日本小児外科学会雑誌  2020/09  (一社)日本小児外科学会
  • 膵内副脾に発生した類表皮嚢胞の1例
    小堀 篤也, 森嶋 計, 下平 健太郎, 青木 裕一, 目黒 由行, 宮戸 秀世, 遠藤 和洋, 笹沼 英紀, 佐久間 康成, 堀江 久永, 細谷 好則, 北山 丈二, 佐田 尚宏
    日本消化器病学会関東支部例会プログラム・抄録集  2020/09  日本消化器病学会-関東支部
  • 【慢性膵炎-ガイドライン改訂に向けて】早期慢性膵炎の概念と診断・治療
    佐田 尚宏, 佐久間 康成, 笹沼 英紀, 小泉 大, 遠藤 和洋, 鈴木 正徳
    臨床消化器内科  2020/09  (株)日本メディカルセンター
     
    <文献概要>早期慢性膵炎の概念は,早期治療介入により病状進行の抑制が期待できる点で重要である.早期慢性膵炎の診断基準は「慢性膵炎臨床診断基準2009」で初めて定義された.その後,2011年に行われた慢性膵炎全国調査,早期慢性膵炎の前方視的コホート・スタディなどの知見の集積を受け,2019年に慢性膵炎臨床診断基準が改訂され,早期慢性膵炎の診断基準も改訂された.2019年の早期慢性膵炎診断基準では,「急性膵炎の既往」が項目として追加されたこと,アルコール摂取量の基準が1日60g(純エタノール換算)に低減されたこと,などがおもな改訂点である.今後のさらなる知見の集積により,未だ不明な点が多い慢性膵炎の病態の理解が進むことを期待したい.
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    乳腺甲状腺超音波医学  2020/09  (一社)日本乳腺甲状腺超音波医学会
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    横山 健介, 牛尾 純, 佐田 尚宏
    胆道  2020/08  日本胆道学会
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    笹沼 英紀, 佐久間 康成, 下平 健太郎, 森嶋 計, 宮戸 秀世, 吉田 淳, 北山 丈二, 佐田 尚宏
    日本外科学会定期学術集会抄録集  2020/08  (一社)日本外科学会
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    大西 康晴, 眞田 幸弘, 岡田 憲樹, 山田 直也, 平田 雄大, 宮原 豪, 片野 巧, 大豆生田 尚彦, 水田 耕一, 佐久間 康成, 佐田 尚宏
    日本外科学会定期学術集会抄録集  2020/08  (一社)日本外科学会
  • Flowcytometryを用いた大腸癌組織における細胞別PD-L1、PD-L2の発現解析の試み
    齋藤 晶, 東条 峰之, 高橋 和也, 木村 有希, 熊谷 祐子, 津久井 秀則, 金丸 理人, 山口 博紀, 佐久間 康成, 川平 洋, 堀江 久永, 細谷 好則, 味村 俊樹, 北山 丈二, 佐田 尚宏
    日本外科学会定期学術集会抄録集  2020/08  (一社)日本外科学会
  • Flowcytometryを用いた胃癌腹膜播種患者の腹腔内遊離細胞の解析
    金丸 理人, 大澤 英之, 高橋 和也, 松本 志郎, 春田 英律, 倉科 憲太郎, 齋藤 心, 山口 博紀, 佐久間 康成, 川平 洋, 堀江 久永, 細谷 好則, 味村 俊樹, 北山 丈二, 佐田 尚宏
    日本外科学会定期学術集会抄録集  2020/08  (一社)日本外科学会
  • 食道癌術前DCF療法の予後に関わる因子の検討
    松本 志郎, 高橋 和也, 金丸 理人, 宇井 崇, 春田 英律, 倉科 憲太郎, 斎藤 心, 山口 博紀, 細谷 好則, 北山 丈二, 佐田 尚宏
    日本外科学会定期学術集会抄録集  2020/08  (一社)日本外科学会
  • 医学生対象内視鏡外科手術トレーニングの報告と縫合結紮手技解析の初回報告
    川平 洋, 前田 佳孝, 松本 志郎, 鈴木 義彦, 淺田 義和, 山口 博紀, 佐久間 康成, 堀江 久永, 細谷 好則, 味村 俊樹, 北山 丈二, 佐田 尚宏
    日本外科学会定期学術集会抄録集  2020/08  (一社)日本外科学会
  • 外科医の服装は患者・家族による診療の評価に影響するのか? 自治医科大学附属病院消化器一般移植外科病棟におけるアンケート調査
    清水 敦, Lefor Alan, 山口 博紀, 佐久間 康成, 堀江 久永, 細谷 好則, 味村 俊樹, 北山 丈二, 佐田 尚宏
    日本外科学会定期学術集会抄録集  2020/08  (一社)日本外科学会
  • 胃全摘後の体重減少・食欲不振に対する六君子湯の治療効果 新規治療ターゲットと新規作用機序の解明を目指したパイロット試験
    田口 昌延, 倉科 憲太郎, 出崎 克也, 松本 志郎, 春田 英律, 山口 博紀, 佐久間 康成, 川平 洋, 堀江 久永, 細谷 好則, 味村 俊樹, 北山 丈二, 矢田 俊彦, 佐田 尚宏
    日本外科学会定期学術集会抄録集  2020/08  (一社)日本外科学会
  • 肝門部領域胆管癌における切除断端と再発形態についての検討
    森嶋 計, 下平 健太郎, 青木 裕一, 三木 厚, 宮戸 英世, 遠藤 和洋, 吉田 淳, 笹沼 英紀, 山口 博紀, 佐久間 康成, 川平 洋, 堀江 久永, 細谷 好則, 味村 俊樹, 北山 丈二, 佐田 尚宏
    日本外科学会定期学術集会抄録集  2020/08  (一社)日本外科学会
  • 消化器外科用新規接着剤の開発
    佐久間 康成, 田口 哲志, 三木 厚, 斉藤 晶, 芝 聡美, 堀江 久永, 細谷 好則, 山口 博紀, 川平 洋, 北山 丈二, 佐田 尚宏
    日本外科学会定期学術集会抄録集  2020/08  (一社)日本外科学会
  • クローン病腸管病変に対する内科外科連携に基づく治療戦略
    太田 学, 伊藤 誉, 津久井 秀則, 本間 祐子, 熊谷 祐子, 東條 峰之, 佐田友 藍, 直井 大志, 田原 真紀子, 巷野 佳彦, 鯉沼 広治, 山口 博紀, 佐久間 康成, 川平 洋, 堀江 久永, 細谷 好則, 味村 俊樹, 北山 丈二, 佐田 尚宏
    日本外科学会定期学術集会抄録集  2020/08  (一社)日本外科学会
  • CD73を標的とした治療による直腸癌に対する放射線治療の増強効果(CD73 targeting therapy enhances the antitumor effect of radiotherapy in rectal cancer)
    津久井 秀則, 堀江 久永, 大澤 英之, 山口 博紀, 佐久間 康成, 川平 洋, 細谷 好則, 味村 俊樹, 吉村 浩太郎, Alan Lefor, 佐田 尚宏, 北山 丈二
    日本外科学会定期学術集会抄録集  2020/08  (一社)日本外科学会
  • 術後膵液瘻ゼロを目指した膵断端処置具の新規開発
    兼田 裕司, 木村 有希, 齋藤 晶, 青木 裕一, 目黒 由行, 森嶋 計, 宮戸 英世, 大澤 英之, 遠藤 和洋, 吉田 淳, 小泉 大, 笹沼 英紀, 山口 博紀, 佐久間 康成, 川平 洋, 堀江 久永, 味村 俊樹, 北山 丈二, Alan Lefor, 佐田 尚宏
    日本外科学会定期学術集会抄録集  2020/08  (一社)日本外科学会
  • 小児肝移植後肝内結石症の診断と治療
    眞田 幸弘, 佐久間 康成, 大西 康晴, 岡田 憲樹, 山田 直也, 平田 雄大, 宮原 豪, 片野 匠, 大豆生田 尚彦, 佐田 尚宏
    日本外科学会定期学術集会抄録集  2020/08  (一社)日本外科学会
  • 腹腔内液中エクソソームを用いた腹膜播種関連バイオマーカーの探索
    大澤 英之, 木村 有希, 齋藤 晶, 山口 博紀, 佐久間 康成, 堀江 久永, 細谷 好則, 佐田 尚宏, 北山 丈二
    日本外科学会定期学術集会抄録集  2020/08  (一社)日本外科学会
  • 器械縫合において粘膜縫合の欠損が腸管吻合部の強度に与える影響
    直井 大志, 堀江 久永, 熊谷 祐子, 太田 学, 東條 峰之, 兼田 裕司, 斎藤 晶, 木村 有希, 津久井 秀則, 本間 祐子, 佐田友 藍, 田原 真紀子, 巷野 佳彦, 鯉沼 広治, 菱川 修司, 佐久間 康成, 細谷 好則, 味村 俊樹, 北山 丈二, 佐田 尚宏
    日本外科学会定期学術集会抄録集  2020/08  (一社)日本外科学会
  • 十二指腸乳頭部癌切除例の長期成績
    小泉 大, 下平 健太郎, 木村 有希, 斉藤 晶, 森嶋 計, 兼田 裕司, 宮戸 秀世, 遠藤 和洋, 笹沼 英紀, 山口 博紀, 川平 洋, 佐久間 康成, 堀江 久永, 細谷 好則, 味村 俊樹, 北山 丈二, 佐田 尚宏
    日本外科学会定期学術集会抄録集  2020/08  (一社)日本外科学会
  • 外科的侵襲・炎症と癌の転移再発 手術侵襲は末梢血中低比重好中球を増加させ遠隔転移を促進する
    熊谷 祐子, 金丸 理人, 大澤 英之, 山口 博紀, 佐久間 康成, 川平 洋, 堀江 久永, 細谷 好則, 味村 俊樹, 北山 丈二, 佐田 尚宏
    日本外科学会定期学術集会抄録集  2020/08  (一社)日本外科学会
  • 淺田 義和, 岡崎 仁昭, 佐田 尚宏, 川平 洋, 山本 真一, 松山 泰
    医学教育  2020/07  (一社)日本医学教育学会
  • 新医師臨床研修制度に準拠したMoodleベースの臨床教育評価システム検討
    淺田 義和, 岡崎 仁昭, 佐田 尚宏, 川平 洋, 山本 真一, 松山 泰
    医学教育  2020/07  (一社)日本医学教育学会
  • 術前CRT施行直腸癌症例に対する側方リンパ節郭清の適応
    井上 賢之, 堀江 久永, 鯉沼 広治, 田原 真紀子, 巷野 佳彦, 清水 徹一郎, 本間 祐子, 津久井 秀則, 熊谷 祐子, 東條 峰之, 佐田友 藍, 直井 大志, 伊藤 誉, 佐久間 康成, 細谷 好則, 味村 俊樹, 北山 丈二, 佐田 尚宏
    日本大腸肛門病学会雑誌  2020/07  (一社)日本大腸肛門病学会
  • 当院における内視鏡摘除後のT1直腸癌追加腸切除適応症例についての検討
    巷野 佳彦, 堀江 久永, 津久井 秀則, 本間 祐子, 熊谷 祐子, 東條 峰之, 佐田友 藍, 清水 徹一郎, 直井 大志, 田原 真紀子, 伊藤 誉, 井上 賢之, 鯉沼 広治, 佐久間 康成, 細谷 好則, 味村 俊樹, 北山 丈二, 佐田 尚宏
    日本大腸肛門病学会雑誌  2020/07  (一社)日本大腸肛門病学会
  • クラインフェルター症候群合併の高度肥満症に対しBariatric surgeryが奏功した1例
    千葉 蒔七, 春田 英律, 齋藤 心, 細谷 好則, 岡田 健太, 松本 志郎, 金丸 理人, 高橋 和也, 北山 丈二, 佐田 尚宏
    日本消化器病学会関東支部例会プログラム・抄録集  2020/07  日本消化器病学会-関東支部
  • 正中弓状靱帯圧迫症候群による下膵十二指腸動脈瘤破裂症例の検討
    森嶋 計, 下平 健太郎, 宮戸 英世, 遠藤 和洋, 吉田 敦, 笹沼 英紀, 佐久間 康成, 佐田 尚宏
    膵臓  2020/07  (一社)日本膵臓学会
  • 10mm以下の非機能性膵神経内分泌腫瘍における診断と治療成績
    池田 恵理子, 牛尾 純, 三輪田 哲郎, 長井 洋樹, 川崎 佑輝, 横山 健介, 沼尾 規且, 玉田 喜一, 佐田 尚宏, 福嶋 敬宜, 山本 博徳
    膵臓  2020/07  (一社)日本膵臓学会
  • Heidelberg大学病院の膵頭十二指腸切除術
    田口 昌延, 佐久間 康成, 小泉 大, 笹沼 英紀, 下平 健太郎, 齋藤 晶, 木村 有希, 青木 裕一, 目黒 由行, 笠原 尚哉, 森嶋 計, 兼田 裕司, 三木 厚, 宮戸 英世, 遠藤 和洋, 吉田 淳, 清水 敦, 山口 博紀, 北山 丈二, 佐田 尚宏
    膵臓  2020/07  (一社)日本膵臓学会
  • 切除可能膵癌に対する術前化学放射線療法の有効性
    三木 厚, 佐久間 康成, 笹沼 英紀, 遠藤 和洋, 吉田 淳, 森嶋 計, 下平 健太郎, 佐田 尚宏
    膵臓  2020/07  (一社)日本膵臓学会
  • 急性膵炎に対する局所合併症治療 左側感染性Walled-off necrosis(WON)に対する小切開Videoscope補助下ネクロセクトミー
    笹沼 英紀, 佐田 尚宏, 下平 健太郎, 森嶋 計, 宮戸 秀世, 遠藤 和洋, 吉田 淳, 佐久間 康成, 北山 丈二
    膵臓  2020/07  (一社)日本膵臓学会
  • 膵全摘術の現状と展望 膵全摘術後の糖尿病コントロールと栄養指標の変化について
    須藤 広誠, 亀井 敬子, 加藤 宏之, 三澤 健之, 海野 倫明, 新田 浩幸, 里井 壯平, 川畑 康成, 大塚 将之, 力山 敏樹, 首藤 毅, 松本 逸平, 岡野 圭一, 鈴木 康之, 佐田 尚宏, 伊佐地 秀司, 杉山 政則, 竹山 宜典
    膵臓  2020/07  (一社)日本膵臓学会
  • 膵全摘術の現状と展望 膵全摘後の脂肪肝発生頻度とそのリスク解析 膵全摘患者に対する前向き実態調査の結果から
    加藤 宏之, 亀井 敬子, 須藤 広誠, 三澤 健之, 海野 倫明, 新田 浩幸, 里井 壯平, 川畑 康成, 大塚 将之, 力山 敏樹, 首藤 毅, 松本 逸平, 岡野 圭一, 鈴木 康之, 佐田 尚宏, 伊佐地 秀司, 杉山 政則, 竹山 宜典
    膵臓  2020/07  (一社)日本膵臓学会
  • 膵全摘術の現状と展望 膵全摘の治療成績と周術期血糖・栄養管理に関する検討と今後の課題
    笹沼 英紀, 佐田 尚宏, 下平 健太郎, 森嶋 計, 宮戸 秀世, 遠藤 和洋, 吉田 淳, 佐久間 康成, 北山 丈二
    膵臓  2020/07  (一社)日本膵臓学会
  • 膵全摘術の現状と展望 膵全摘患者のQOL調査 多施設共同前向き研究結果
    亀井 敬子, 松本 逸平, 加藤 宏之, 須藤 広誠, 三澤 健之, 海野 倫明, 新田 浩幸, 里井 壯平, 川畑 康成, 大塚 将之, 力山 敏樹, 首藤 毅, 岡野 圭一, 鈴木 康之, 佐田 尚宏, 伊佐地 秀司, 杉山 政則, 竹山 宜典
    膵臓  2020/07  (一社)日本膵臓学会
  • 難治性排便障害に対する経肛門的洗腸療法 当院での経肛門的洗腸療法の治療成績
    本間 祐子, 味村 俊樹, 田口 深雪, 西田 路子, 堀江 久永, 佐田 尚宏
    日本大腸肛門病学会雑誌  2020/06  (一社)日本大腸肛門病学会
  • 排便機能外来立ち上げから1年間の診療実績
    本間 祐子, 味村 俊樹, 堀江 久永, 佐田 尚宏
    日本大腸肛門病学会雑誌  2020/06  (一社)日本大腸肛門病学会
  • 肛門指診と肛門内圧検査値の比較・検討
    本間 祐子, 味村 俊樹, 田島 桂子, 小野寺 敏江, 藤元 歩美, 堀江 久永, 佐田 尚宏
    日本大腸肛門病学会雑誌  2020/06  (一社)日本大腸肛門病学会
  • 大西 康晴, 眞田 幸弘, 岡田 憲樹, 山田 直也, 平田 雄大, 宮原 豪, 片野 匠, 大豆生田 尚彦, 藤原 エリ, 吉田 幸世, 大柿 景子, 大友 慎也, 今井 利美, 水田 耕一, 佐久間 康成, 佐田 尚宏
    日本小児外科学会雑誌  2020/04  (一社)日本小児外科学会
  • 当院でのABTHERドレッシングキットの使用経験と工夫について
    篠原 翔一, 笹沼 英紀, 篠田 祐之, 窪木 大悟, 宮戸 秀世, 森嶋 計, 吉田 淳, 遠藤 和洋, 佐久間 康成, 堀江 久永, 細谷 好則, 北山 丈二, 佐田 尚宏
    日本腹部救急医学会雑誌  2020/02  (一社)日本腹部救急医学会
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    中尾 祐樹, 笹沼 英紀, 吉田 淳, 遠藤 和洋, 三木 厚, 森嶋 計, 田口 昌延, 佐久間 康成, 佐田 尚宏
    日本腹部救急医学会雑誌  2020/02  (一社)日本腹部救急医学会
  • 大豆生田 尚彦, 森嶋 計, 宮戸 秀世, 片野 匠, 篠原 翔一, 兼田 裕司, 遠藤 和洋, 三木 厚, 吉田 淳, 笹沼 英紀, 山口 博紀, 佐久間 康成, 川平 洋, 堀江 久永, 細谷 好則, 味村 俊樹, 北山 丈二, 佐田 尚宏
    日本内分泌学会雑誌  2020/02  (一社)日本内分泌学会
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    倉科 憲太郎, 細谷 好則, 北山 丈二, 山口 博紀, 齋藤 心, 春田 英律, 松本 志郎, 宇井 崇, 金丸 理人, 高橋 和也, 大澤 英之, 川平 洋, 堀江 久永, 佐久間 康成, 佐田 尚宏
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    齋藤 晶, 大澤 英之, 高橋 和也, 木村 有希, 東條 峰之, 熊谷 祐子, 金丸 理人, 津久井 秀則, 佐田 尚宏, 北山 丈二
    日本成人病(生活習慣病)学会会誌  2020/01  日本成人病(生活習慣病)学会
  • 腹腔鏡下スリーブ状胃切除術における高血圧症改善因子の検討
    金丸 理人, 春田 英律, 細谷 好則, 倉科 憲太郎, 齋藤 心, 宇井 崇, 松本 志郎, 高橋 和也, 山口 博紀, 佐久間 康成, 堀江 久永, 北山 丈二, 佐田 尚宏
    日本成人病(生活習慣病)学会会誌  2020/01  日本成人病(生活習慣病)学会
  • 片野 匠, 眞田 幸弘, 大豆生田 尚彦, 宮原 豪, 平田 雄大, 岡田 憲樹, 山田 直也, 大西 康晴, 佐久間 康成, 佐田 尚宏
    日本小児栄養消化器肝臓学会雑誌  2019/12  (一社)日本小児栄養消化器肝臓学会
  • 眞田 幸弘, 久間 康成, 大西 康晴, 岡田 憲樹, 山田 直也, 平田 雄大, 宮原 豪, 片野 匠, 大豆生田 尚彦, 佐田 尚宏
    日本小児栄養消化器肝臓学会雑誌  2019/12  (一社)日本小児栄養消化器肝臓学会
  • 岡田 憲樹, 眞田 幸弘, 大豆生田 尚彦, 宮原 豪, 片野 匠, 平田 雄大, 山田 直也, 大西 康晴, 佐久間 康成, 佐田 尚宏
    日本小児栄養消化器肝臓学会雑誌  2019/12  (一社)日本小児栄養消化器肝臓学会
  • 食道癌とS状結腸癌に対し、鏡視下食道亜全摘術と腹腔鏡下S状結腸切除術を施行した一例
    窪木 大悟, 春田 英律, 松本 志郎, 倉科 憲太郎, 細谷 好則, 佐久間 康成, 川平 洋, 堀江 久永, 北山 丈二, 佐田 尚宏
    日本内視鏡外科学会雑誌  2019/12  (一社)日本内視鏡外科学会
  • 肝内胆管癌疑いの症例に対して腹腔鏡下肝切除を行い肝類上皮細胞肉芽腫と診断された1例
    吉田 淳, 佐久間 康成, 宮戸 英世, 森嶋 計, 三木 厚, 兼田 裕司, 遠藤 和洋, 笹沼 英紀, 川平 洋, 堀江 久永, 細谷 好則, 味村 俊樹, 北山 丈二, 佐田 尚宏
    日本内視鏡外科学会雑誌  2019/12  (一社)日本内視鏡外科学会
  • 胃癌・大腸癌に対して腹腔鏡下に同時切除を行った9症例の検討
    倉科 憲太郎, 細谷 好則, 春田 英律, 松本 志郎, 齋藤 心, 宇井 崇, 金丸 理人, 高橋 和也, 佐久間 康成, 堀江 久永, 味村 俊樹, 川平 洋, 北山 丈二, 佐田 尚宏
    日本内視鏡外科学会雑誌  2019/12  (一社)日本内視鏡外科学会
  • 内視鏡手術手技の初学者にとって3次元内視鏡のアドバンテージはあるか?
    松本 志郎, 遠藤 和宏, 川平 洋, 細谷 好則, 佐久間 康成, 堀江 久永, 味村 俊樹, 北山 丈二, 佐田 尚宏
    日本内視鏡外科学会雑誌  2019/12  (一社)日本内視鏡外科学会
  • 腹腔鏡下直腸切断術におけるインターシードの使用経験
    田原 真紀子, 堀江 久永, 太田 学, 本間 祐子, 熊谷 祐子, 佐田友 藍, 直井 大志, 巷野 佳彦, 伊藤 誉, 鯉沼 広治, 佐久間 康成, 味村 俊樹, 細谷 好則, 北山 丈二, 佐田 尚宏
    日本内視鏡外科学会雑誌  2019/12  (一社)日本内視鏡外科学会
  • 予防的人工肛門造設からみた直腸癌術後の縫合不全対策
    佐田友 藍, 鯉沼 広治, 太田 学, 本間 祐子, 田原 真紀子, 巷野 佳彦, 伊藤 誉, 佐久間 康成, 川平 洋, 堀江 久永, 細谷 好則, 味村 俊樹, 北山 丈二, 佐田 尚宏
    日本内視鏡外科学会雑誌  2019/12  (一社)日本内視鏡外科学会
  • 直腸癌術前化学放射線治療実施症例に対する腹腔鏡下側方リンパ節郭清の適応について
    堀江 久永, 鯉沼 広治, 伊藤 誉, 田原 真紀子, 佐田友 藍, 巷野 佳彦, 本間 祐子, 太田 学, 佐久間 康成, 川平 洋, 細谷 好則, 味村 俊樹, 北山 丈二, 佐田 尚宏
    日本内視鏡外科学会雑誌  2019/12  (一社)日本内視鏡外科学会
  • 当科における直腸癌に対するTaTMEの導入と短期治療成績
    巷野 佳彦, 堀江 久永, 田原 真紀子, 太田 学, 本間 祐子, 佐田友 藍, 伊藤 誉, 鯉沼 広治, 佐久間 康成, 川平 洋, 細谷 好則, 味村 俊樹, 北山 丈二, 佐田 尚宏
    日本内視鏡外科学会雑誌  2019/12  (一社)日本内視鏡外科学会
  • スリーブ状胃切除術の問題点 当院の肥満外科手術の治療成績と今後の課題
    春田 英律, 細谷 好則, 倉科 憲太郎, 松本 志郎, 齋藤 心, 宇井 崇, 金丸 理人, 高橋 和也, 川平 洋, 佐久間 康成, 堀江 久永, 味村 俊樹, 北山 丈二, 佐田 尚宏
    日本内視鏡外科学会雑誌  2019/12  (一社)日本内視鏡外科学会
  • 寺谷 工, 笠原 尚哉, 浦橋 泰然, 藤本 康弘, 小林 英司, 後藤 昌史, 佐田 尚宏, 北山 丈二
    Organ Biology  2019/10  (一社)日本臓器保存生物医学会
  • 山田 直也, 唐澤 直義, 木村 博昭, 水田 耕一, 佐久間 康成, 佐田 尚宏, 高橋 将文
    Organ Biology  2019/10  (一社)日本臓器保存生物医学会
  • 岡田 憲樹, 寺谷 工, 眞田 幸弘, 大西 康晴, 菱川 修司, 佐久間 康成, 佐田 尚宏
    Organ Biology  2019/10  (一社)日本臓器保存生物医学会
  • 潰瘍形成により穿通を来した腸間膜脂肪腫を伴うLipomatosisの1例
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    日本臨床外科学会雑誌  2019/10  日本臨床外科学会
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    崎尾 亮太郎, 伊藤 誉, 太田 学, 本間 祐子, 佐田友 藍, 田原 真紀子, 巷野 佳彦, 山口 博紀, 佐久間 康成, 川平 洋, 堀江 久永, 細谷 好則, 味村 俊樹, 北山 丈二, 佐田 尚宏
    日本臨床外科学会雑誌  2019/10  日本臨床外科学会
  • 診断的ESDによって確定診断しえた超高分化型胃癌の一手術例
    松本 志郎, 細谷 好則, 高橋 和也, 金丸 理人, 春田 英律, 倉科 憲太郎, 佐久間 康成, 堀江 久永, 北山 丈二, 佐田 尚宏
    日本臨床外科学会雑誌  2019/10  日本臨床外科学会
  • 腫瘍出血による褐色細胞腫クリーゼに対して体外循環補助下に副腎摘出術を施行し救命し得た1例
    片野 匠, 森嶋 計, 青木 裕一, 山口 博紀, 佐久間 康成, 川平 洋, 堀江 久永, 細谷 好則, 味村 俊樹, 北山 丈二, 佐田 尚宏
    日本臨床外科学会雑誌  2019/10  日本臨床外科学会
  • 大学病院初期研修医に対する、魅力的な外科研修環境の構築
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    日本臨床外科学会雑誌  2019/10  日本臨床外科学会
  • 排便機能および排便機能障害について考える 排便機能外来立ち上げ後1年間の診療実績
    本間 祐子, 味村 俊樹, 太田 学, 佐田友 藍, 田原 真紀子, 伊藤 誉, 巷野 佳彦, 山口 博紀, 佐久間 康成, 川平 洋, 堀江 久永, 細谷 好則, 北山 丈二, 佐田 尚宏
    日本臨床外科学会雑誌  2019/10  日本臨床外科学会
  • 外科臨床におけるAIの利用 Deep Learningによる早期大腸癌病変における内視鏡診断支援の試み ESD/EMRか手術か?
    川平 洋, 中島 寛隆, 上里 昌也, 宮内 英聡, 山口 博紀, 佐久間 康成, 堀江 久永, 細谷 好則, 味村 俊樹, 北山 丈二, 松原 久裕, 佐田 尚宏
    日本臨床外科学会雑誌  2019/10  日本臨床外科学会
  • 新しい医療機器の開発と臨床応用 外科医用ウェアラブルチェア「アルケリス」の開発と臨床使用の経験
    川平 洋, 中村 亮一, 下村 義弘, 大城 崇司, 岡住 慎一, 山口 博紀, 佐久間 康成, 堀江 久永, 細谷 好則, 味村 俊樹, 北山 丈二, アラン・レフォー, 佐田 尚宏
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  • 眞田 幸弘, 佐久間 康成, 大西 康晴, 岡田 憲樹, 山田 直也, 平田 雄大, 宮原 豪, 片野 匠, 大豆生田 尚彦, 横山 健介, 矢野 智則, 山本 博徳, 佐田 尚宏
    胆道  2019/10  日本胆道学会
  • 窪木 大悟, 笹沼 英紀, 橋本 雄介, 三木 厚, 吉田 淳, 森嶋 計, 遠藤 和洋, 佐久間 康成, 堀江 久永, 細谷 好則, 北山 丈二, 佐田 尚宏
    胆道  2019/10  日本胆道学会
  • 篠原 翔一, 笹沼 英紀, 宮戸 英世, 森嶋 計, 三木 厚, 遠藤 和洋, 吉田 淳, 佐久間 康成, 北山 丈二, 佐田 尚宏
    胆道  2019/10  日本胆道学会
  • 吉田 淳, 笹沼 英紀, 片野 匠, 篠原 翔一, 森嶋 計, 三木 厚, 宮戸 英世, 遠藤 和洋, 佐久間 康成, 堀江 久永, 細谷 好則, 北山 丈二, 佐田 尚宏
    胆道  2019/10  日本胆道学会
  • リウマチに対してメトトレキサート内服中に発症した、肝原発悪性リンパ腫の一例  [Not invited]
    大豆生田 尚彦, 森嶋 計, 宮戸 秀世, 遠藤 和洋, 三木 厚, 吉田 厚, 笹沼 英紀, 山口 博紀, 佐久間 康成, 川平 洋, 堀江 久永, 細谷 好則, 味村 俊樹, 北山 丈二, 佐田 尚宏
    日本臨床外科学会雑誌  2019/10  日本臨床外科学会
  • 春田 英律, 細谷 好則, 岡田 健太, 倉科 憲太郎, 齋藤 心, 松本 志郎, 金丸 理人, 高橋 和也, 山口 博紀, 堀江 久永, 北山 丈二, 佐田 尚宏
    肥満研究  2019/10  (一社)日本肥満学会
  • 上野 愛莉, 栗田 悠人, 磯 愛, 石坂 陽子, 沼山 翔太朗, 岡田 理恵, 狐塚 正子, 春田 英律, 細谷 好則, 佐田 尚宏
    肥満研究  2019/10  (一社)日本肥満学会
  • 山野井 徳子, 橋本 愛, 森田 直美, 春田 英律, 高久 美子, 堀江 久永, 竹内 護, 細谷 好則, 佐田 尚宏
    肥満研究  2019/10  (一社)日本肥満学会
  • 佐久間 康成, 寺谷 工, 笠原 尚哉, 三木 厚, 春田 英律, 細谷 好則, 北山 丈二, 佐田 尚宏
    肥満研究  2019/10  (一社)日本肥満学会
  • 春田 英律, 細谷 好則, 岡田 健太, 倉科 憲太郎, 齋藤 心, 松本 志郎, 金丸 理人, 高橋 和也, 山口 博紀, 堀江 久永, 北山 丈二, 佐田 尚宏
    肥満研究  2019/10  (一社)日本肥満学会
  • 田口 昌延, 出崎 克也, 細谷 好則, 矢田 俊彦, 佐田 尚宏
    肥満研究  2019/10  (一社)日本肥満学会
  • 腹膜播種陽性胃癌に対するSOX+PTX腹腔内投与併用療法
    宮戸 秀世, 山口 博紀, 齋藤 心, 細谷 好則, 春田 英律, 倉科 憲太郎, 堀江 久永, 佐久間 康成, 北山 丈二, 佐田 尚宏
    日本癌治療学会学術集会抄録集  2019/10  (一社)日本癌治療学会
  • SP120および10D7G2にて評価したhENT1発現量はゲムシタビンアジュバント療法を施行した膵癌患者の予後を予測する可能性がある 多施設共同JASPAC 01試験(The hENT1 evaluated by SP120 and 10D7G2 had the potential to predict the prognosis in the patients with pancreatic cancer treated with adjuvant gemcitabine: Collaborative study of the JASPAC 01 trial)
    岡村 行泰, 安川 覚, 成松 宏人, 朴 成和, 福冨 晃, 小西 大, 森永 聡一郎, 外山 博近, 金岡 祐次, 中森 正二, 佐田 尚宏, 山北 圭介, 坂本 裕彦, 柳澤 昭夫, 上坂 克彦, 膵癌補助化学療法グループ
    日本癌治療学会学術集会抄録集  2019/10  (一社)日本癌治療学会
  • 腹腔内液中エクソソームマイクロRNAを用いた胃癌腹膜播種症例のリキッドバイオプシー
    大澤 英之, 木村 有希, 齊籐 晶, 山口 博紀, 細谷 好則, 佐田 尚宏, 北山 丈二
    日本癌治療学会学術集会抄録集  2019/10  (一社)日本癌治療学会
  • リウマチに対してメトトレキサート内服中に発症した、肝原発悪性リンパ腫の一例
    大豆生田 尚彦, 森嶋 計, 宮戸 秀世, 遠藤 和洋, 三木 厚, 吉田 厚, 笹沼 英紀, 山口 博紀, 佐久間 康成, 川平 洋, 堀江 久永, 細谷 好則, 味村 俊樹, 北山 丈二, 佐田 尚宏
    日本臨床外科学会雑誌  2019/10  日本臨床外科学会
  • 膵十二指腸動脈瘤を併発した正中弓状靱帯症候群に対し、腹腔鏡下胃切除術中に靱帯切離を行った一例
    窪木 大悟, 倉科 憲太郎, 松本 志郎, 春田 英律, 細谷 好則, 山口 博紀, 斎藤 心, 川平 洋, 味村 俊樹, 堀江 久永, 佐久間 康成, 北山 丈二, 佐田 尚宏
    日本臨床外科学会雑誌  2019/10  日本臨床外科学会
  • 眞田 幸弘, 佐久間 康成, 大西 康晴, 岡田 憲樹, 山田 直也, 岡田 優子, 横山 孝二, 熊谷 秀規, 虻川 大樹, 水田 耕一, 佐田 尚宏
    日本小児栄養消化器肝臓学会雑誌  2019/10  (一社)日本小児栄養消化器肝臓学会
  • 岡田 憲樹, 眞田 幸弘, 山田 直也, 大西 康晴, 岡田 優子, 横山 孝二, 熊谷 秀規, 笠原 群生, 佐久間 康成, 佐田 尚宏
    日本小児栄養消化器肝臓学会雑誌  2019/10  (一社)日本小児栄養消化器肝臓学会
  • 篠田 祐之, 春田 英律, 細谷 好則, 岡田 健太, 倉科 憲太郎, 齋藤 心, 松本 志郎, 金丸 理人, 高橋 和也, 山口 博紀, 笹沼 英紀, 堀江 久永, 北山 丈二, 佐田 尚宏
    肥満研究  2019/10  (一社)日本肥満学会
  • 千葉 蒔七, 春田 英律, 細谷 好則, 岡田 健太, 倉科 憲太郎, 齋藤 心, 松本 志郎, 金丸 理人, 高橋 和也, 山口 博紀, 笹沼 英紀, 佐久間 康成, 堀江 久永, 北山 丈二, 佐田 尚宏
    肥満研究  2019/10  (一社)日本肥満学会
  • 膵癌切除後のS-1補助化学療法患者においてhENT1高発現は独立した予後不良因子である(hENT1 expression is a prognostic factor in patients with pancreatic cancer treated with adjuvant S-1 chemotherapy)
    岡村 行泰, 安川 覚, 成松 宏人, 朴 成和, 福冨 晃, 小西 大, 森永 聡一郎, 外山 博近, 金岡 祐次, 清水 泰博, 中森 正二, 佐田 尚宏, 上坂 克彦
    日本癌学会総会記事  2019/09  日本癌学会
  • 膵癌は、他の独立した癌病巣・線維化病変に、それらの形成する微小環境を乗っ取り、転移しやすい(Pancreatic carcinoma metastasis to other carcinoma lesions and fibrotic regions, overtaking the stromal microenvironment)
    仲矢 丈雄, 大城 久, 斎藤 匠, 佐久間 康成, 曽我部 将哉, 山本 真一, 辻 賢太郎, 仲矢 道雄, 遠藤 俊輔, 堀江 久永, 佐田 尚宏, 仁木 利郎, 田中 亨
    日本癌学会総会記事  2019/09  日本癌学会
  • 放射線照射直腸癌におけるアデノシン及びアデノシン産生酵素CD73発現について(Adenosine and adenosine producing 5'-Nucleotidase/CD73 in irradiated rectal cancer)
    津久井 秀則, 大澤 英之, 山口 博紀, 佐久間 康成, 細谷 好則, 堀江 久永, 藤井 博文, 佐田 尚宏, 北山 丈二
    日本癌学会総会記事  2019/09  日本癌学会
  • 当科における下部直腸癌に対するtaTMEの導入と短期治療成績
    田原 真紀子, 太田 学, 太白 健一, 本間 祐子, 熊谷 祐子, 佐田友 藍, 直井 大志, 清水 徹一郎, 巷野 佳彦, 伊藤 誉, 井上 賢之, 鯉沼 広治, 味村 俊樹, 佐田 尚宏
    日本大腸肛門病学会雑誌  2019/09  (一社)日本大腸肛門病学会
  • 腹腔鏡下腹会陰式直腸切断術後に発生し、経腹的・経会陰的に修復した会陰ヘルニアの1例
    高橋 和也, 堀江 久永, 太田 学, 本間 祐子, 佐田友 藍, 清水 徹一郎, 直井 大志, 田原 真紀子, 巷野 佳彦, 伊藤 誉, 井上 賢之, 鯉沼 広治, 味村 俊樹, 北山 丈二, 佐田 尚宏
    日本大腸肛門病学会雑誌  2019/09  (一社)日本大腸肛門病学会
  • 難治性排便障害に対する経肛門的洗腸療法の治療成績
    本間 祐子, 味村 俊樹, 田原 真紀子, 巷野 佳彦, 清水 徹一郎, 太田 学, 太白 健一, 津久井 秀則, 熊谷 祐子, 東條 峰之, 伊藤 誉, 佐田友 藍, 直井 大志, 鯉沼 広治, 堀江 久永, 北山 丈二, 佐田 尚宏
    日本大腸肛門病学会雑誌  2019/09  (一社)日本大腸肛門病学会
  • Flowcytometryを用いた大腸癌組織における細胞別PD-L1、PD-L2の発現解析の試み
    齋藤 晶, 東條 峰之, 大澤 英之, 佐久間 康成, 細谷 好則, 堀江 久永, 佐田 尚宏, 北山 丈二
    日本大腸肛門病学会雑誌  2019/09  (一社)日本大腸肛門病学会
  • 術前化学放射線治療実施症例に対する側方リンパ節郭清の適応について
    堀江 久永, 鯉沼 広治, 井上 賢之, 田原 真紀子, 巷野 佳彦, 清水 徹一郎, 本間 祐子, 太田 学, 太白 健一, 津久井 秀則, 熊谷 祐子, 東條 峰之, 伊藤 誉, 佐田 藍, 直井 大志, 味村 俊樹, 北山 丈二, 佐田 尚宏
    日本大腸肛門病学会雑誌  2019/09  (一社)日本大腸肛門病学会
  • 進行大腸癌所属リンパ節におけるPD-1/PD-L1分子の発現解析
    津久井 秀則, 斎藤 晶, 東條 峰之, 田原 真紀子, 巷野 佳彦, 清水 徹一郎, 本間 祐子, 太田 学, 太白 健一, 熊谷 祐子, 伊藤 誉, 佐田友 藍, 直井 大志, 鯉沼 広治, 大澤 英之, 味村 俊樹, 堀江 久永, 佐田 尚宏, 北山 丈二
    日本大腸肛門病学会雑誌  2019/09  (一社)日本大腸肛門病学会
  • 排便障害診療におけるチーム医療の問題点と対策
    本間 祐子, 味村 俊樹, 清水 徹一郎, 田原 真紀子, 巷野 佳彦, 太田 学, 津久井 秀則, 太白 健一, 熊谷 祐子, 東條 峰之, 伊藤 誉, 佐田友 藍, 直井 大志, 鯉沼 広治, 堀江 久永, 北山 丈二, 佐田 尚宏
    日本大腸肛門病学会雑誌  2019/09  (一社)日本大腸肛門病学会
  • 専門領域の連携による炎症性腸疾患の治療 クローン病腸管狭窄に対するKono-S吻合の短期成績
    佐田友 藍, 堀江 久永, 本間 祐子, 直井 大志, 清水 徹一郎, 田原 真紀子, 巷野 佳彦, 伊藤 誉, 井上 賢之, 鯉沼 広治, 味村 俊樹, 北山 丈二, 佐田 尚宏
    日本大腸肛門病学会雑誌  2019/09  (一社)日本大腸肛門病学会
  • 平田 雄大, 眞田 幸弘, 大西 康晴, 岡田 憲樹, 山田 直也, 宮原 豪, 片野 匠, 大豆生田 尚彦, 水田 耕一, 佐久間 康成, 佐田 尚宏
    移植  2019/09  (一社)日本移植学会
  • 小俣 佳菜子, 岡田 憲樹, 宮原 豪, 眞田 幸弘, 大西 康晴, 福田 真也, 小高 淳, 桑島 真理, 山形 崇倫, 笠原 群生, 佐久間 康成, 佐田 尚宏
    移植  2019/09  (一社)日本移植学会
  • 大西 康晴, 眞田 幸弘, 岡田 憲樹, 山田 直也, 平田 雄大, 片野 匠, 宮原 豪, 藤原 エリ, 吉田 幸世, 大柿 景子, 大友 慎也, 今井 利美, 水田 耕一, 佐久間 康成, 佐田 尚宏
    移植  2019/09  (一社)日本移植学会
  • 岡田 憲樹, 眞田 幸弘, 宮原 豪, 片野 匠, 平田 雄大, 山田 直也, 大西 康晴, 今井 利美, 大友 慎也, 大柿 景子, 吉田 幸世, 藤原 エリ, 佐久間 康成, 佐田 尚宏
    移植  2019/09  (一社)日本移植学会
  • 眞田 幸弘, 佐久間 康成, 大西 康晴, 岡田 憲樹, 山田 直也, 平田 雄大, 宮原 豪, 片野 匠, 藤原 エリ, 吉田 幸世, 佐田 尚宏
    移植  2019/09  (一社)日本移植学会
  • 晩期合併症・トランジション 先天性胆道拡張症術後晩期合併症の検討  [Not invited]
    吉田 淳, 笹沼 英紀, 宮戸 英世, 森嶋 計, 三木 厚, 兼田 裕司, 遠藤 和洋, 山口 博紀, 佐久間 康成, 川平 洋, 堀江 久永, 細谷 好則, 味村 俊樹, 北山 丈二, 佐田 尚宏
    日本膵・胆管合流異常研究会プロシーディングス  2019/09  日本膵・胆管合流異常研究会
  • ヒト結腸直腸癌における腫瘍細胞および浸潤性骨髄細胞に対するPD-L1およびPD-L2の定量的評価(Quantitative evaluation of PD-L1 and PD-L2 on tumor cells and infiltrating myeloid cells in human colorectal cancer)
    齋藤 晶, 東條 峰之, 熊谷 祐子, 佐田友 藍, 田原 真紀子, 巷野 佳彦, 伊藤 誉, 大澤 英之, 佐久間 康成, 細谷 好則, 堀江 久永, 佐田 尚宏, 北山 丈二
    日本癌学会総会記事  2019/09  日本癌学会
  • がんの免疫逃避機構における好中球細胞外トラップ(NETs)の意義(Neutrophil extracellular traps(NETs) in cancer immune escape mechanisms)
    北山 丈二, 金丸 理人, 大澤 英之, 熊谷 祐子, 佐田 尚宏
    日本癌学会総会記事  2019/09  日本癌学会
  • 通過障害を伴う進行胃癌に対し、PTEG造設後に腹腔内化学療法を行い奏功した1例
    佐藤 孝弘, 高橋 和也, 春田 英律, 山口 博紀, 金丸 理人, 松本 志郎, 宇井 崇, 倉科 憲太郎, 齋藤 心, 細谷 好則, 北山 丈二, 佐田 尚宏
    日本臨床外科学会雑誌  2019/08  日本臨床外科学会
  • 腹腔鏡下直腸切断術を施行した難治性cap polyposisの1例
    関口 和正, 田原 真紀子, 堀江 久永, 宮原 悠三, 本間 祐子, 清水 徹一郎, 巷野 佳彦, 井上 賢之, 鯉沼 広治, 佐久間 康成, 味村 俊樹, 細谷 好則, 北山 丈二, 佐田 尚宏, 小林 泰俊
    日本臨床外科学会雑誌  2019/07  日本臨床外科学会
  • 術前化学療法腋窩リンパ節転移陰性乳癌症例におけるセンチネルリンパ節生検省略の可能性の検討
    宮崎 千絵子, 藤田 崇史, 佐々木 裕美子, 西田 紗希, 芝 聡美, 櫻木 雅子, 塩澤 幹雄, 佐田 尚宏
    日本乳癌学会総会プログラム抄録集  2019/07  (一社)日本乳癌学会
  • 医学部生からレジデントまでを対象とした内視鏡外科手術トレーニングの初回報告
    川平 洋, 前田 佳孝, 鈴木 義彦, 淺田 義和, 遠藤 和洋, 山本 真一, 堀江 久永, 細谷 好則, 北山 丈二, 佐田 尚宏
    日本消化器外科学会総会  2019/07  (一社)日本消化器外科学会
  • 右側結腸手術における術前機械的前処置省略の効果
    直井 大志, 堀江 久永, 巷野 佳彦, 井上 賢之, 鯉沼 広治, 佐久間 康成, 細谷 好則, 味村 俊樹, 北山 丈二, 佐田 尚宏
    日本消化器外科学会総会  2019/07  (一社)日本消化器外科学会
  • 腹腔内液中エクソソームを用いた胃癌腹膜播種症例のリキッドバイオプシー
    大澤 英之, 齋藤 晶, 熊谷 祐子, 山口 博紀, 細谷 好則, 佐田 尚宏, 北山 丈二
    日本消化器外科学会総会  2019/07  (一社)日本消化器外科学会
  • 術前CRTと側方郭清による側方リンパ節転移の制御
    堀江 久永, 鯉沼 広治, 井上 賢之, 田原 真紀子, 巷野 佳彦, 佐久間 康成, 細谷 好則, 味村 俊樹, 北山 丈二, 佐田 尚宏
    日本消化器外科学会総会  2019/07  (一社)日本消化器外科学会
  • 開腹術後腹腔内滲出好中球上のPD-L1発現
    金丸 理人, 大澤 英之, 高橋 和也, 松本 志郎, 春田 英律, 倉科 健太郎, 山口 博紀, 細谷 好則, 佐田 尚宏, 北山 丈二
    日本消化器外科学会総会  2019/07  (一社)日本消化器外科学会
  • 当院における肥満外科手術の減量効果と代謝改善効果の中長期成績
    春田 英律, 細谷 好則, 岡田 健太, 齋藤 心, 倉科 憲太郎, 金丸 理人, 石橋 俊, 山口 博紀, 北山 丈二, 佐田 尚宏
    日本消化器外科学会総会  2019/07  (一社)日本消化器外科学会
  • 【肝胆膵】肝移植と合併症対策 当施設における小児生体肝移植後胆管合併症の現状と治療成績
    眞田 幸弘, 片野 匠, 平田 雄大, 山田 直也, 岡田 憲樹, 大西 康晴, 佐久間 康成, 佐田 尚宏, 水田 耕一
    日本消化器外科学会総会  2019/07  (一社)日本消化器外科学会
  • 大腸癌所属リンパ節内のTリンパ球におけるPD-1の発現について
    津久井 秀則, 齋藤 晶, 東條 峰之, 大澤 英之, 佐久間 康成, 細谷 好則, 堀江 久永, 佐田 尚宏, 北山 丈二
    日本消化器外科学会総会  2019/07  (一社)日本消化器外科学会
  • 潰瘍性大腸炎のため内服していたメサラジン腸溶錠が狭窄腸管に停留しイレウスをきたした腹膜癌の一例
    清水 敦, 堀江 久永, 佐久間 康成, 細谷 好則, 北山 丈二, 伊藤 千紗, 内田 真一郎, 藤原 寛行, 丹波 嘉一郎, 佐田 尚宏
    日本消化器外科学会総会  2019/07  (一社)日本消化器外科学会
  • Flowcytometryを用いた大腸癌組織における細胞別PD-L1、PD-L2の発現解析の試み
    齋藤 晶, 東條 峰之, 大澤 英之, 佐久間 康成, 細谷 好則, 堀江 久永, 佐田 尚宏, 北山 丈二
    日本消化器外科学会総会  2019/07  (一社)日本消化器外科学会
  • 当院における75歳以上の切除不能進行再発大腸癌患者に対する全身化学療法の現状
    清水 徹一郎, 堀江 久永, 佐田友 藍, 直井 大志, 田原 真紀子, 巷野 佳彦, 井上 賢之, 鯉沼 広治, 佐田 尚宏, 山口 博紀
    日本消化器外科学会総会  2019/07  (一社)日本消化器外科学会
  • 結腸間膜付着部を認識する2方向アプローチと術前血管画像構築を組み合わせた安全な腹腔鏡下横行結腸癌手術
    鯉沼 広治, 堀江 久永, 佐田友 藍, 直井 大志, 巷野 佳彦, 田原 真紀子, 伊藤 誉, 井上 賢之, 味村 俊樹, 佐田 尚宏
    日本消化器外科学会総会  2019/07  (一社)日本消化器外科学会
  • 【胃】胃癌腹膜播種に対する治療戦略 腹膜播種陽性胃癌に対するSOX+PTX腹腔内投与併用療法
    齋藤 心, 山口 博紀, 細谷 好則, 金丸 理人, 春田 英律, 倉科 憲太郎, 堀江 久永, 佐久間 康成, 佐田 尚宏, 北山 丈二
    日本消化器外科学会総会  2019/07  (一社)日本消化器外科学会
  • 腎細胞癌膵転移切除症例の検討  [Not invited]
    吉田 淳, 佐久間 康成, 森嶋 計, 三木 厚, 遠藤 和洋, 笹沼 英紀, 堀江 久永, 細谷 好則, 北山 丈二, 佐田 尚宏
    日本消化器外科学会総会  2019/07  (一社)日本消化器外科学会
  • 在宅での看取りを考える 自宅で最期をむかえた癌患者の検討
    櫻木 雅子, 藤田 崇史, 佐々木 裕美子, 西田 紗季, 芝 聡美, 宮崎 千絵子, 塩澤 幹雄, 水沼 洋文, 北山 丈二, 佐田 尚宏
    日本乳癌学会総会プログラム抄録集  2019/07  (一社)日本乳癌学会
  • 自家組織移植による乳房再建施行後、再建乳房内に局所再発を認めた2例
    西田 紗季, 藤田 崇史, 佐々木 裕美子, 芝 聡美, 櫻木 雅子, 塩澤 幹雄, 宇田 宏一, 吉村 浩太郎, 北山 丈二, 佐田 尚宏
    日本乳癌学会総会プログラム抄録集  2019/07  (一社)日本乳癌学会
  • 新規オキシコドン塩酸塩水和物徐放錠による皮膚有害事象
    清水 敦, 竹内 瑞枝, 齋藤 暢是, 荒川 昌史, 江 秉綸, 五味 遥, 高橋 和也, 春田 英律, 細谷 好則, 佐田 尚宏, 丹波 嘉一郎
    Palliative Care Research  2019/06  (NPO)日本緩和医療学会
  • 青木 裕一, 笹沼 英紀, 森嶋 計, 三木 厚, 遠藤 和洋, 吉田 淳, 佐久間 康成, 佐田 尚宏
    膵臓  2019/06  (一社)日本膵臓学会
  • 吉田 淳, 佐久間 康成, 森嶋 計, 遠藤 和洋, 三木 厚, 笹沼 英紀, 堀江 久永, 細谷 好則, 北山 丈二, 佐田 尚宏
    膵臓  2019/06  (一社)日本膵臓学会
  • 池田 恵理子, 牛尾 純, 横山 健介, 多田 大和, 川崎 佑輝, 玉田 喜一, 福嶋 敬宜, 佐田 尚宏
    膵臓  2019/06  (一社)日本膵臓学会
  • 食道神経内分泌癌(NEC)7例の検討
    金子 勇貴, 齋藤 心, 山口 博紀, 春田 英律, 松本 四郎, 倉科 憲太郎, 細谷 好則, 北山 丈二, 仁木 利郎, 佐田 尚宏
    日本食道学会学術集会プログラム・抄録集  2019/06  (NPO)日本食道学会
  • 低肺機能症例に対する縦隔鏡併用非開胸食道切除術の導入
    倉科 憲太郎, 細谷 好則, 愛甲 丞, 瀬戸 泰之, 齋藤 心, 春田 英律, 松本 志郎, 宇井 崇, 北山 丈二, 佐田 尚宏
    日本食道学会学術集会プログラム・抄録集  2019/06  (NPO)日本食道学会
  • 小腸癌に対する外科治療の意義 原発性小腸癌24例の臨床病理学的検討
    井上 賢之, 堀江 久永, 鯉沼 広治, 田原 真紀子, 巷野 佳彦, 本間 祐子, 佐田友 藍, 清水 徹一郎, 伊藤 誉, 直井 大志, 熊谷 祐子, 津久井 秀則, 東條 峰之, 佐久間 康成, 細谷 好則, 味村 俊樹, 北山 丈二, 佐田 尚宏
    日本大腸肛門病学会雑誌  2019/05  (一社)日本大腸肛門病学会
  • 術前化学放射線療法(CRT)を行った下部進行直腸癌症例の術後CEA値は予後を予測するか
    森本 光昭, 堀江 久永, 鯉沼 広治, 井上 賢之, 森 和亮, 田原 真紀子, 直井 大志, 佐田友 藍, 巷野 佳彦, 東條 峰之, 津久井 秀則, 宮原 悠三, 伊藤 誉, 太白 健一, 丸山 博行, 清水 徹一郎, 太田 学, 佐田 尚宏
    日本大腸肛門病学会雑誌  2019/05  (一社)日本大腸肛門病学会
  • 間質微小環境の乗っ取りによる膵癌から原発性結腸癌への転移(Metastasis of pancreatic cancer in primary colon cancer by overtaking the stromal microenvironment)
    仲矢 丈雄, 大城 久, 斎藤 匠, 佐久間 康成, 堀江 久永, 佐田 尚宏, 田中 亨
    日本病理学会会誌  2019/04  (一社)日本病理学会
  • 大腸内視鏡検査により発症した脾損傷の1例
    本間 祐子, 井上 賢之, 清水 徹一郎, 巷野 佳彦, 田原 真紀子, 佐久間 康成, 堀江 久永, 細谷 好則, 味村 俊樹, 北山 丈二, 佐田 尚宏
    日本大腸検査学会雑誌  2019/04  (社)日本大腸検査学会
  • 当院における直腸癌内視鏡切除後の追加切除適応症例についての検討
    巷野 佳彦, 堀江 久永, 津久井 秀則, 本間 祐子, 熊谷 祐子, 東條 峰之, 佐田友 藍, 清水 徹一郎, 直井 大志, 田原 真紀子, 伊藤 誉, 森 和亮, 井上 賢之, 鯉沼 広治, 佐久間 康成, 細谷 好則, 味村 俊樹, 北山 丈二, 佐田 尚宏
    日本外科学会定期学術集会抄録集  2019/04  (一社)日本外科学会
  • 高度膀胱浸潤を伴う直腸・S状結腸癌に対する治療戦略と当科における手術成績
    田原 真紀子, 堀江 久永, 本間 祐子, 熊谷 祐子, 佐田友 藍, 直井 大志, 清水 徹一郎, 伊藤 誉, 巷野 佳彦, 井上 賢之, 鯉沼 広治, 佐久間 康成, 細谷 好則, 味村 俊樹, 北山 丈二, 佐田 尚宏
    日本外科学会定期学術集会抄録集  2019/04  (一社)日本外科学会
  • 当科における術前静脈血栓塞栓症(VTE)スクリーニングの有用性
    清水 徹一郎, 窓岩 清治, 堀江 久永, 斎藤 晶, 芝 聡美, 三木 厚, 佐久間 康成, 細谷 好則, 佐田 尚宏
    日本外科学会定期学術集会抄録集  2019/04  (一社)日本外科学会
  • 開腹術後腹腔内滲出好中球の臨床的意義
    金丸 理人, 大澤 英之, 松本 志郎, 春田 英律, 倉科 憲太郎, 山口 博紀, 佐久間 康成, 堀江 久永, 細谷 好則, 北山 丈二, 佐田 尚宏
    日本外科学会定期学術集会抄録集  2019/04  (一社)日本外科学会
  • 術前CRTが施行された直腸癌症例に対する側方郭清の適応について
    堀江 久永, 鯉沼 広治, 井上 賢之, 田原 真紀子, 巷野 佳彦, 清水 徹一郎, 本間 祐子, 津久井 秀則, 熊谷 祐子, 東條 峰之, 伊藤 誉, 佐田友 藍, 直井 大志, 佐久間 康成, 細谷 好則, 味村 俊樹, 北山 丈二, 佐田 尚宏
    日本外科学会定期学術集会抄録集  2019/04  (一社)日本外科学会
  • 消化器癌手術患者における末梢血中低比重好中球の術中推移
    熊谷 祐子, 金丸 理人, 大澤 英之, 山口 博紀, 佐久間 康成, 堀江 久永, 細谷 好則, 北山 丈二, 佐田 尚宏
    日本外科学会定期学術集会抄録集  2019/04  (一社)日本外科学会
  • クローン病腸管病変に対する内科外科連携に基づく治療戦略
    伊藤 誉, 堀江 久永, 津久井 秀則, 本間 祐子, 熊谷 祐子, 東條 峰之, 佐田友 藍, 直井 大志, 清水 徹一郎, 田原 真紀子, 巷野 佳彦, 井上 賢之, 鯉沼 広治, 佐久間 康成, 細谷 好則, 味村 俊樹, 北山 丈二, 佐田 尚宏
    日本外科学会定期学術集会抄録集  2019/04  (一社)日本外科学会
  • 放射線照射が癌細胞におけるアデノシン産生酵素CD73に与える影響について
    津久井 秀則, 大澤 英之, 山口 博紀, 佐久間 康成, 細谷 好則, 堀江 久永, 藤井 博文, 北山 丈二, 佐田 尚宏
    日本外科学会定期学術集会抄録集  2019/04  (一社)日本外科学会
  • 腹腔内液中エクソソームを用いた胃癌腹膜播種治療におけるバイオマーカー探索
    大澤 英之, 齋藤 晶, 熊谷 祐子, 佐久間 康成, 山口 博紀, 堀江 久永, 細谷 好則, 佐田 尚宏, 北山 丈二
    日本外科学会定期学術集会抄録集  2019/04  (一社)日本外科学会
  • 脾彎曲部結腸癌に対する腹腔鏡下手術の工夫
    鯉沼 広治, 堀江 久永, 田原 真紀子, 清水 徹一郎, 巷野 佳彦, 井上 賢之, 本間 祐子, 伊藤 誉, 佐田友 藍, 直井 大志, 佐久間 康成, 細谷 好則, 味村 俊樹, 北山 丈二, 佐田 尚宏
    日本外科学会定期学術集会抄録集  2019/04  (一社)日本外科学会
  • 12年の長期経過観察中に悪性化したと考えられる膵粘液嚢胞性腫瘍の一例  [Not invited]
    高橋 礼, 笹沼 英紀, 三木 厚, 森嶋 計, 吉田 淳, 遠藤 和洋, 佐久間 康成, 堀江 久永, 細谷 好則, 北山 丈二, 佐田 尚宏, 池田 恵理子, 福島 敬宜
    日本消化器病学会関東支部例会プログラム・抄録集  2019/04  日本消化器病学会-関東支部
  • 十二指腸乳頭部腫瘍に対する外科的乳頭切除術による段階的治療戦略  [Not invited]
    小泉 大, 斎藤 晶, 青木 裕一, 森嶋 計, 兼田 裕司, 三木 厚, 遠藤 和洋, 笹沼 英紀, 吉田 淳, 佐久間 康成, 堀江 久永, 細谷 好則, 北山 丈二, 佐田 尚宏
    日本外科学会定期学術集会抄録集  2019/04  (一社)日本外科学会
  • 胃管癌8例の臨床病理学的検討
    齋藤 心, 細谷 好則, 松原 大祐, 春田 英律, 倉科 憲太郎, 松本 志郎, 北山 丈二, 山口 博紀, 佐久間 康成, 堀江 久永, 佐田 尚宏
    日本外科学会定期学術集会抄録集  2019/04  (一社)日本外科学会
  • 腹腔動脈狭窄を伴う特発性下膵十二指腸動脈破裂の1例
    小泉 恵, 吉田 淳, 高橋 和也, 青木 裕一, 田口 昌延, 森嶋 計, 三木 厚, 遠藤 和洋, 笹沼 英紀, 佐久間 康成, 堀江 久永, 細谷 好則, 北山 丈二, 佐田 尚宏
    日本臨床外科学会雑誌  2019/03  日本臨床外科学会
  • 術前診断しえた特発性大網出血の1例  [Not invited]
    高橋 和也, 笹沼 英紀, 青木 裕一, 森嶋 計, 兼田 裕司, 遠藤 和洋, 吉田 淳, 佐久間 康成, 堀江 久永, 細谷 好則, 北山 丈二, 佐田 尚宏
    日本腹部救急医学会雑誌  2019/02  (一社)日本腹部救急医学会
  • 鼠径部ヘルニア嵌頓症例における経過時間と腸切除の検討  [Not invited]
    小泉 大, 斎藤 晶, 青木 裕一, 森嶋 計, 兼田 裕司, 三木 厚, 遠藤 和洋, 笹沼 英紀, 吉田 淳, 佐久間 康成, 堀江 久永, 細谷 好則, 北山 丈二, 佐田 尚宏
    日本腹部救急医学会雑誌  2019/02  (一社)日本腹部救急医学会
  • 膵十二指腸動脈瘤の3例  [Not invited]
    渡部 晃佑, 吉田 淳, 高橋 和也, 青木 裕一, 田口 昌延, 森嶋 計, 三木 厚, 兼田 裕司, 遠藤 和洋, 笹沼 英紀, 佐久間 康成, 堀江 久永, 細谷 好則, 北山 丈二, 佐田 尚宏
    日本腹部救急医学会雑誌  2019/02  (一社)日本腹部救急医学会
  • 膵十二指腸動脈瘤の3例
    渡部 晃佑, 吉田 淳, 高橋 和也, 青木 裕一, 田口 昌延, 森嶋 計, 三木 厚, 兼田 裕司, 遠藤 和洋, 笹沼 英紀, 佐久間 康成, 堀江 久永, 細谷 好則, 北山 丈二, 佐田 尚宏
    日本腹部救急医学会雑誌  2019/02  (一社)日本腹部救急医学会
  • 横隔膜上憩室を伴う食道平滑筋腫の1例
    倉科 憲太郎, 細谷 好則, 春田 英律, 松本 志郎, 齋藤 心, 宇井 崇, 金丸 理人, 高橋 和也, 佐久間 康成, 堀江 久永, 北山 丈二, 佐田 尚宏
    日本消化器病学会関東支部例会プログラム・抄録集  2019/02  日本消化器病学会-関東支部
  • 術前診断しえた特発性大網出血の1例
    高橋 和也, 笹沼 英紀, 青木 裕一, 森嶋 計, 兼田 裕司, 遠藤 和洋, 吉田 淳, 佐久間 康成, 堀江 久永, 細谷 好則, 北山 丈二, 佐田 尚宏
    日本腹部救急医学会雑誌  2019/02  (一社)日本腹部救急医学会
  • 鼠径部ヘルニア嵌頓症例における経過時間と腸切除の検討
    小泉 大, 斎藤 晶, 青木 裕一, 森嶋 計, 兼田 裕司, 三木 厚, 遠藤 和洋, 笹沼 英紀, 吉田 淳, 佐久間 康成, 堀江 久永, 細谷 好則, 北山 丈二, 佐田 尚宏
    日本腹部救急医学会雑誌  2019/02  (一社)日本腹部救急医学会
  • 経カテーテル動脈塞栓術後に胆汁性腹膜炎を合併し、ドレナージに続く肝切除を行った肝損傷の1例  [Not invited]
    田中 保平, 伊澤 祥光, 渡邊 伸貴, 山黒 友丘, 富永 経一郎, 新庄 貴文, 太田 真, 米川 力, 間藤 卓, 青木 裕一, 笹沼 英紀, 佐田 尚宏
    日本救急医学会関東地方会雑誌  2019/02  日本救急医学会-関東地方会
  • 部分的脾動脈塞栓後に残胃血流を考慮し幽門側胃切除術および脾臓摘出術を施行したITP合併胃癌
    金子 勇貴, 齋藤 心, 高橋 大二郎, 松本 志郎, 宇井 崇, 春田 英律, 倉科 憲太郎, 宮戸 秀世, 細谷 好則, 北山 丈二, 佐田 尚宏
    日本胃癌学会総会記事  2019/02  (一社)日本胃癌学会
  • 当科における高度肥満症に対する腹腔鏡下スリーブ状胃切除術の取り組みと治療成績
    春田 英律, 細谷 好則, 倉科 憲太郎, 斎藤 心, 宇井 崇, 松本 志郎, 金丸 理人, 高橋 和也, 山口 博紀, 佐久間 康成, 堀江 久永, 北山 丈二, 佐田 尚宏
    日本成人病(生活習慣病)学会会誌  2019/01  日本成人病(生活習慣病)学会
  • 治癒切除を受けた消化器癌患者のメトホルミン内服による生存率改善について
    熊谷 祐子, 大澤 英之, 山口 博紀, 佐久間 康成, 堀江 久永, 細谷 好則, 佐田 尚宏, 北山 丈二
    日本成人病(生活習慣病)学会会誌  2019/01  日本成人病(生活習慣病)学会
  • 肥満外科手術のコツ 腹腔鏡下スリーブ状胃切除術における周術期管理と手技の工夫
    春田 英律, 細谷 好則, 斎藤 心, 倉科 憲太郎, 宇井 崇, 松本 志郎, 高橋 和也, 佐久間 康成, 堀江 久永, 北山 丈二, 佐田 尚宏
    日本内視鏡外科学会雑誌  2018/12  (一社)日本内視鏡外科学会
  • 肥満外科治療の現状と展望 当科における腹腔鏡下スリーブ状胃切除術の取組みと今後の展望
    春田 英律, 細谷 好則, 斎藤 心, 倉科 憲太郎, 宇井 崇, 松本 志郎, 高橋 和也, 佐久間 康成, 堀江 久永, 北山 丈二, 佐田 尚宏
    日本内視鏡外科学会雑誌  2018/12  (一社)日本内視鏡外科学会
  • 下行結腸進行癌に対する腹腔鏡下手術の工夫
    鯉沼 広治, 堀江 久永, 佐田友 藍, 直井 大志, 田原 真紀子, 伊藤 誉, 清水 徹一郎, 井上 賢之, 巷野 佳彦, 佐久間 康成, 細谷 好則, 味村 俊樹, 北山 丈二, 佐田 尚宏
    日本内視鏡外科学会雑誌  2018/12  (一社)日本内視鏡外科学会
  • ウェアラブルチェア「アルケリス」の使用経験 内視鏡外科手術の負担軽減を目指して
    井上 賢之, 川平 洋, 清水 徹一郎, 田原 真紀子, 巷野 佳彦, 遠藤 和洋, 佐久間 康成, 堀江 久永, 細谷 好則, 味村 俊樹, 北山 丈二, 佐田 尚宏
    日本内視鏡外科学会雑誌  2018/12  (一社)日本内視鏡外科学会
  • 当科で施行した縦隔鏡併用非開胸食道切除術3症例の経験
    倉科 憲太郎, 細谷 好則, 愛甲 丞, 瀬戸 泰之, 齋藤 心, 春田 英律, 松本 志郎, 宇井 崇, 金丸 理人, 高橋 和也, 堀江 久永, 佐久間 康成, 北山 丈二, 佐田 尚宏
    日本内視鏡外科学会雑誌  2018/12  (一社)日本内視鏡外科学会
  • 短期間に2度の腹腔鏡下手術を施行した腸管子宮内膜症の1例
    金子 勇貴, 齋藤 心, 佐田友 藍, 宮戸 秀世, 佐藤 宗勝, 巷野 佳彦, 堀江 久永, 佐田 尚宏
    日本内視鏡外科学会雑誌  2018/12  (一社)日本内視鏡外科学会
  • 腹腔鏡下右側結腸手術に対するERASプロトコル導入の短期成績
    直井 大志, 堀江 久永, 鯉沼 広治, 井上 賢之, 伊藤 誉, 巷野 佳彦, 田原 真紀子, 清水 徹一郎, 佐田友 藍, 佐久間 康成, 細谷 好則, 味村 俊樹, 北山 丈二, 佐田 尚宏
    日本内視鏡外科学会雑誌  2018/12  (一社)日本内視鏡外科学会
  • 腹腔鏡下低位前方切除術後に発症した下肢コンパートメント症候群の2例
    田原 真紀子, 堀江 久永, 津久井 秀則, 熊谷 祐子, 佐田友 藍, 清水 徹一郎, 直井 大志, 巷野 佳彦, 伊藤 誉, 井上 賢之, 鯉沼 広治, 佐久間 康成, 細谷 好則, 北山 丈二, 佐田 尚宏
    日本内視鏡外科学会雑誌  2018/12  (一社)日本内視鏡外科学会
  • 自治医科大学附属病院「鏡視下手術部」の役割
    細谷 好則, 佐久間 康成, 堀江 久永, 北山 丈二, 佐田 尚宏
    日本内視鏡外科学会雑誌  2018/12  (一社)日本内視鏡外科学会
  • 抗血栓薬内服患者に対する腹腔鏡下大腸手術の安全性について
    清水 徹一郎, 堀江 久永, 熊谷 祐子, 佐田友 藍, 直井 大志, 田原 真紀子, 巷野 佳彦, 井上 賢之, 鯉沼 広治, 佐久間 康成, 細谷 好則, 北山 丈二, 佐田 尚宏
    日本内視鏡外科学会雑誌  2018/12  (一社)日本内視鏡外科学会
  • 腹腔鏡下右半結腸切除における腸管引き出し操作による副右結腸静脈からの出血の1例
    佐田友 藍, 堀江 久永, 直井 大志, 清水 徹一郎, 田原 真紀子, 伊藤 誉, 巷野 佳彦, 井上 賢之, 鯉沼 広治, 佐久間 康成, 細谷 好則, 味村 俊樹, 北山 丈二, 佐田 尚宏
    日本内視鏡外科学会雑誌  2018/12  (一社)日本内視鏡外科学会
  • 術前シミュレーションと3D内視鏡を用いた安全な腹腔鏡下側方リンパ節郭清の導入
    堀江 久永, 鯉沼 広治, 井上 賢之, 田原 真紀子, 巷野 佳彦, 清水 徹一郎, 伊藤 誉, 佐田友 藍, 直井 大志, 佐久間 康成, 細谷 好則, 味村 俊樹, 北山 丈二, 佐田 尚宏
    日本内視鏡外科学会雑誌  2018/12  (一社)日本内視鏡外科学会
  • 腹腔鏡下肝切除とRFAを併用して治療した肝細胞癌5例の検討  [Not invited]
    森嶋 計, 青木 裕一, 田口 昌延, 遠藤 和洋, 笹沼 英紀, 吉田 淳, 佐久間 康成, 堀江 久永, 細谷 好則, 北山 丈二, 佐田 尚宏
    日本内視鏡外科学会雑誌  2018/12  (一社)日本内視鏡外科学会
  • 内視鏡補助下に切除した膵内分泌腫瘍術後の異時性転移性副腎腫瘍の1例  [Not invited]
    吉田 淳, 佐久間 康成, 青木 裕一, 田口 昌延, 森嶋 計, 遠藤 和洋, 笹沼 英紀, 堀江 久永, 細谷 好則, 北山 丈二, 佐田 尚宏
    日本内視鏡外科学会雑誌  2018/12  (一社)日本内視鏡外科学会
  • 当科の後腹膜鏡下副腎摘出術の手術成績の検討  [Not invited]
    小泉 大, 田口 昌延, 森嶋 計, 遠藤 和洋, 笹沼 英紀, 吉田 淳, 佐久間 康成, 堀江 久永, 細谷 好則, 北山 丈二, 佐田 尚宏
    日本内視鏡外科学会雑誌  2018/12  (一社)日本内視鏡外科学会
  • 腹腔鏡下膵体尾部切除(Lap-DP)における定型化膵離断 膵臓の厚みとカートリッジに関する検討  [Not invited]
    笹沼 英紀, 佐久間 康成, 木村 有希, 青木 裕一, 田口 昌延, 森嶋 計, 遠藤 和洋, 吉田 淳, 堀江 久永, 細谷 好則, 北山 丈二, 佐田 尚宏
    日本内視鏡外科学会雑誌  2018/12  (一社)日本内視鏡外科学会
  • 腹腔鏡下肝切除とRFAを併用して治療した肝細胞癌5例の検討  [Not invited]
    森嶋 計, 青木 裕一, 田口 昌延, 遠藤 和洋, 笹沼 英紀, 吉田 淳, 佐久間 康成, 堀江 久永, 細谷 好則, 北山 丈二, 佐田 尚宏
    日本内視鏡外科学会雑誌  2018/12  (一社)日本内視鏡外科学会
  • 内視鏡補助下に切除した膵内分泌腫瘍術後の異時性転移性副腎腫瘍の1例  [Not invited]
    吉田 淳, 佐久間 康成, 青木 裕一, 田口 昌延, 森嶋 計, 遠藤 和洋, 笹沼 英紀, 堀江 久永, 細谷 好則, 北山 丈二, 佐田 尚宏
    日本内視鏡外科学会雑誌  2018/12  (一社)日本内視鏡外科学会
  • 当科の後腹膜鏡下副腎摘出術の手術成績の検討  [Not invited]
    小泉 大, 田口 昌延, 森嶋 計, 遠藤 和洋, 笹沼 英紀, 吉田 淳, 佐久間 康成, 堀江 久永, 細谷 好則, 北山 丈二, 佐田 尚宏
    日本内視鏡外科学会雑誌  2018/12  (一社)日本内視鏡外科学会
  • 腹腔鏡下膵体尾部切除(Lap-DP)における定型化膵離断 膵臓の厚みとカートリッジに関する検討  [Not invited]
    笹沼 英紀, 佐久間 康成, 木村 有希, 青木 裕一, 田口 昌延, 森嶋 計, 遠藤 和洋, 吉田 淳, 堀江 久永, 細谷 好則, 北山 丈二, 佐田 尚宏
    日本内視鏡外科学会雑誌  2018/12  (一社)日本内視鏡外科学会
  • 食道癌治療後再燃に対して縦隔鏡併用非開胸食道切除術を施行した1例
    塚本 恵, 倉科 憲太郎, 細谷 好則, 愛甲 丞, 瀬戸 泰之, 松本 志郎, 春田 英律, 北山 丈二, 佐田 尚宏
    日本胸部外科学会関東甲信越地方会要旨集  2018/11  日本胸部外科学会-関東甲信越地方会
  • 外科の緩和ケア バランス麻酔のアプローチに学ぶ外科医のtotal distressマネジメント
    清水 敦, 佐久間 康成, 細谷 好則, 堀江 久永, 藤田 崇史, 山口 博紀, 北山 丈二, 佐田 尚宏
    日本臨床外科学会雑誌  2018/10  日本臨床外科学会
  • 「地域医療の実践」と「医師のキャリア形成」の両立 自治医科大学の取り組み
    深井 晴成, 遠藤 和洋, 小泉 大, 笹沼 英紀, 佐久間 康成, 堀江 久永, 細谷 好則, 北山 丈二, 佐田 尚宏, 山本 真一, 遠藤 俊輔
    日本臨床外科学会雑誌  2018/10  日本臨床外科学会
  • 急速な経過をたどった乳房領域の壊死性筋膜炎の一例
    扇原 香澄, 塩澤 幹雄, 西田 紗季, 田中 裕美子, 芝 聡美, 櫻木 雅子, 藤田 崇史, 北山 丈二, 佐田 尚宏, 秋根 大, 富永 経一郎
    日本臨床外科学会雑誌  2018/10  日本臨床外科学会
  • 75歳以上高齢者大腸癌症例における腹腔鏡下手術の検討
    高橋 礼, 田原 真紀子, 本間 祐子, 佐田友 藍, 清水 徹一郎, 井上 賢之, 巷野 佳彦, 鯉沼 広治, 佐久間 康成, 味村 俊樹, 堀江 久永, 細谷 好則, 北山 丈二, 佐田 尚宏
    日本臨床外科学会雑誌  2018/10  日本臨床外科学会
  • 腹痛にて発症した乳癌小腸転移の一例
    窪木 大悟, 堀江 久永, 森島 計, 本間 祐子, 田原 真紀子, 井上 賢之, 櫻木 雅子, 藤田 崇史, 佐久間 康成, 細谷 好則, 北山 丈二, 佐田 尚宏
    日本臨床外科学会雑誌  2018/10  日本臨床外科学会
  • 胃癌腹膜播種に対するSOX+PTX腹腔内投与併用化学療法の新規導入施設における治療成績
    山口 博紀, 金丸 理人, 大澤 英之, 松本 志郎, 倉科 憲太郎, 春田 英律, 細谷 好則, 藤井 博文, 北山 丈二, 佐田 尚宏
    日本癌治療学会学術集会抄録集  2018/10  (一社)日本癌治療学会
  • 根治切除可能であったTrousseau症候群を合併した進行胃癌の1例
    齋藤 匠, 倉科 憲太郎, 細谷 好則, 山口 博紀, 益子 貴史, 春田 英律, 齋藤 心, 宇井 崇, 松本 志郎, 金丸 理人, 高橋 和也, 堀江 久永, 佐久間 康成, 北山 丈二, 佐田 尚宏
    日本臨床外科学会雑誌  2018/10  日本臨床外科学会
  • 肥満に対する外科治療の最前線 当院における肥満外科手術の取り組みと治療成績
    春田 英律, 細谷 好則, 倉科 憲太郎, 斎藤 心, 宇井 崇, 松本 志郎, 金丸 理人, 高橋 和也, 山口 博紀, 佐久間 康成, 堀江 久永, 北山 丈二, 佐田 尚宏
    日本臨床外科学会雑誌  2018/10  日本臨床外科学会
  • 3D-CT angiographyによる術前シミュレーションと2方向間膜アプローチ法を組み合わせた腹腔鏡下右側大腸癌手術の定型化への試み
    田原 真紀子, 鯉沼 広治, 津久井 秀則, 熊谷 祐子, 清水 徹一郎, 直井 大志, 巷野 佳彦, 伊藤 誉, 井上 賢之, 佐久間 康成, 細谷 好則, 味村 俊樹, 堀江 久永, 北山 丈二, 佐田 尚宏
    日本臨床外科学会雑誌  2018/10  日本臨床外科学会
  • 複雑な部分内臓逆位症を伴う総胆管結石症に対し手術を行った1例  [Not invited]
    丸藤 琴音, 吉田 淳, 笹沼 英紀, 宮戸 秀世, 目黒 由行, 森嶋 計, 三木 厚, 遠藤 和洋, 小泉 大, 佐久間 康成, 堀江 久永, 細谷 好則, 北山 丈二, 佐田 尚宏
    日本臨床外科学会雑誌  2018/10  日本臨床外科学会
  • 慢性膵炎急性増悪を契機に脾膿瘍を合併した1例  [Not invited]
    寺田 茉位子, 吉田 淳, 佐久間 康成, 木村 有希, 青木 裕一, 森嶋 計, 遠藤 和洋, 笹沼 英紀, 堀江 久永, 細谷 好則, 北山 丈二, 佐田 尚宏
    日本臨床外科学会雑誌  2018/10  日本臨床外科学会
  • 膵頭部癌に対して膵頭十二指腸切除術を施行し膵尾側断端閉鎖を行った一例  [Not invited]
    倉田 佳彦, 木村 有希, 青木 裕一, 森嶋 計, 遠藤 和洋, 笹沼 英紀, 吉田 淳, 佐久間 康成, 堀江 久永, 細谷 好則, 北山 丈二, 佐田 尚宏
    日本臨床外科学会雑誌  2018/10  日本臨床外科学会
  • 好中球細胞外トラップ(NETs)による開腹術後腹膜再発促進機構(Neutrophil extracellular traps(NETs) on postoperative peritoneal surface may support the tumor recurrence on peritoneum)
    金丸 理人, 大澤 英之, 高橋 和也, 松本 志郎, 春田 英律, 倉科 憲太郎, 山口 博紀, 佐久間 康成, 堀江 久永, 細谷 好則, 佐田 尚宏, 北山 丈二
    日本癌学会総会記事  2018/09  日本癌学会
  • 細谷 好則, 春田 英律, 松本 志郎, 倉科 憲太郎, 斎藤 心, 岡田 健太, 海老原 健, 石橋 俊, 矢田 俊彦, 北山 丈二, 佐田 尚宏
    肥満研究  2018/09  (一社)日本肥満学会
  • 消化器癌手術患者の末梢血中低比重好中球と術後転移再発との関連について(Low density neutrophils(LDN) in postoperative peripheral blood may assist the recurrence of gastrointestinal cancer)
    熊谷 祐子, 金丸 理人, 大澤 英之, 山口 博紀, 佐久間 康成, 堀江 久永, 細谷 好則, 佐田 尚宏, 北山 丈二
    日本癌学会総会記事  2018/09  日本癌学会
  • 腹腔環境の特殊性に基づいた新規腹膜播種治療(Treatment of peritoneal dissemination based on the unique microenvironment in peritoneal cavity)
    北山 丈二, 金丸 理人, 大澤 英之, 熊谷 祐子, 山口 博紀, 細谷 好則, 松崎 圭祐, 佐田 尚宏
    日本癌学会総会記事  2018/09  日本癌学会
  • 原発性十二指腸癌におけるムチンタンパク発現と悪性化機序解明(Functional blockade of MUC1 can inhibit the progression of duodenum adenocarcinoma)
    芝 聡美, 三木 厚, 大澤 英之, 寺谷 工, 佐久間 康成, アラン・レフォー, 北山 丈二, 佐田 尚宏
    日本癌学会総会記事  2018/09  日本癌学会
  • 担癌マウスリンパ節におけるアデノシン脱リン酸化酵素(CD39,CD73)発現についての解析(Expression of adenosine generating ecto-enzymes, CD39 and CD73, in lymphocytes in tumor bearing mouse)
    津久井 秀則, 大澤 英之, 山口 博紀, 佐久間 康成, 細谷 好則, 堀江 久永, 藤井 博文, 佐田 尚宏, 北山 丈二
    日本癌学会総会記事  2018/09  日本癌学会
  • 腹腔鏡下直腸切断術における人工肛門造設の工夫
    巷野 佳彦, 堀江 久永, 太田 学, 宮原 悠三, 津久井 秀則, 本間 祐子, 太白 健一, 熊谷 祐子, 東條 峰之, 佐田友 藍, 清水 徹一郎, 直井 大志, 田原 真紀子, 伊藤 誉, 井上 賢之, 丸山 博行, 鯉沼 広治, 味村 俊樹, 北山 丈二, 佐田 尚宏
    日本大腸肛門病学会雑誌  2018/09  (一社)日本大腸肛門病学会
  • 直腸原発Goblet cell carcinoidに対し腹腔鏡下直腸切断術を施行した1例
    井上 賢之, 堀江 久永, 本間 祐子, 佐田友 藍, 清水 徹一郎, 田原 真紀子, 森 和亮, 伊藤 誉, 巷野 佳彦, 鯉沼 広治, 佐久間 康成, 細谷 好則, 味村 俊樹, 北山 丈二, 佐田 尚宏
    日本大腸肛門病学会雑誌  2018/09  (一社)日本大腸肛門病学会
  • 残尿測定による直腸癌術後排尿障害の評価
    東條 峰之, 堀江 久永, 太田 学, 宮原 悠三, 津久井 秀則, 本間 祐子, 太白 健一, 熊谷 祐子, 佐田友 藍, 清水 徹一郎, 直井 大志, 巷野 佳彦, 田原 真紀子, 伊藤 誉, 井上 賢之, 丸山 博行, 鯉沼 広治, 味村 俊樹, 北山 丈二, 佐田 尚宏
    日本大腸肛門病学会雑誌  2018/09  (一社)日本大腸肛門病学会
  • 肛門機能の諸問題 排便障害診療の進歩と課題 20年の経験に基づいて
    味村 俊樹, 本間 祐子, 清水 徹一郎, 巷野 佳彦, 田原 真紀子, 井上 賢之, 鯉沼 広治, 堀江 久永, 佐田 尚宏
    日本大腸肛門病学会雑誌  2018/09  (一社)日本大腸肛門病学会
  • IBD治療における内科・外科・肛門科の連携 クローン病腸管病変に対する内科外科連携に基づく治療戦略
    伊藤 誉, 堀江 久永, 本間 祐子, 直井 大志, 清水 徹一郎, 田原 真紀子, 巷野 佳彦, 井上 賢之, 鯉沼 広治, 佐久間 康成, 細谷 好則, 味村 俊樹, 北山 丈二, 佐田 尚宏, 矢野 智則, 砂田 圭二郎, 山本 博徳
    日本大腸肛門病学会雑誌  2018/09  (一社)日本大腸肛門病学会
  • 東條 峰之, 小泉 大, 齋藤 晶, 目黒 由行, 田口 昌延, 三木 厚, 宮戸 秀世, 遠藤 和洋, 笹沼 英紀, 佐久間 康成, 佐田 尚宏
    胆道  2018/08  日本胆道学会
  • 当科における非拡張型膵・胆管合流異常症の治療成績
    深井 晴成, 笹沼 英紀, 木村 有希, 青木 祐一, 田口 昌延, 森嶋 計, 遠藤 和洋, 吉田 淳, 佐久間 康成, 佐田 尚宏
    日本膵・胆管合流異常研究会プロシーディングス  2018/08  日本膵・胆管合流異常研究会
  • 下行結腸癌異時性孤立性脾転移の1例
    松宮 美沙希, 三木 厚, 川口 英之, 兼田 裕司, 遠藤 和洋, 小泉 大, 笹沼 英紀, 佐久間 康成, 堀江 久永, 細谷 好則, 北山 丈二, 佐田 尚宏
    日本臨床外科学会雑誌  2018/07  日本臨床外科学会
  • 術後膵液瘻ゼロを目指した膵空腸吻合の工夫 Blumgart変法自治医大方式
    小泉 大, 田口 昌延, 三木 厚, 遠藤 和洋, 笹沼 英紀, 佐久間 康成, 堀江 久永, 細谷 好則, 北山 丈二, 佐田 尚宏
    日本消化器外科学会総会  2018/07  (一社)日本消化器外科学会
  • 腹膜播種の診断と治療の工夫 腹膜播種陽性胃癌に対するSOX+PTX腹腔内投与併用化学療法の新規導入施設における治療成績
    齋藤 心, 山口 博紀, 松本 志郎, 倉科 憲太郎, 佐久間 康成, 春田 英律, 堀江 久永, 細谷 好則, 北山 丈二, 佐田 尚宏
    日本消化器外科学会総会  2018/07  (一社)日本消化器外科学会
  • 開腹手術後の腹腔内滲出好中球由来細胞外トラップ(NETs)の臨床的意義
    金丸 理人, 大澤 英之, 松本 志郎, 春田 英律, 倉科 憲太郎, 宮戸 秀世, 山口 博紀, 細谷 好則, 佐田 尚宏, 北山 丈二
    日本消化器外科学会総会  2018/07  (一社)日本消化器外科学会
  • 当院における腹腔鏡下スリーブ状胃切除術の周術期管理と手技の工夫
    春田 英律, 細谷 好則, 岡田 健太, 齋藤 心, 倉科 憲太郎, 松本 志郎, 石橋 俊, 北山 丈二, 佐田 尚宏
    日本消化器外科学会総会  2018/07  (一社)日本消化器外科学会
  • 胃癌腹膜播種手術症例における予後因子としての腹腔洗浄液中CEA mRNA定量値
    山口 博紀, 石神 浩徳, 松本 志郎, 宇井 崇, 春田 英律, 倉科 憲太郎, 齋藤 心, 細谷 好則, 佐田 尚宏, 北山 丈二
    日本消化器外科学会総会  2018/07  (一社)日本消化器外科学会
  • 早期胃癌ESD非治癒切除症例274例の検討
    松本 志郎, 宇井 崇, 春田 英律, 倉科 憲太郎, 斎藤 心, 堀江 久永, 佐久間 康成, 細谷 好則, 北山 丈二, 佐田 尚宏
    日本消化器外科学会総会  2018/07  (一社)日本消化器外科学会
  • 消化器外科手術における術前血清total cholesterol値と術後感染症との関連について
    森本 光昭, 堀江 久永, 井上 賢之, 伊藤 誉, 森 和亮, 田原 真紀子, 鯉沼 広治, 北山 丈二, 細谷 好則, 佐田 尚宏
    日本消化器外科学会総会  2018/07  (一社)日本消化器外科学会
  • 骨盤内臓全摘術後の骨盤死腔炎の予防には有茎大網充填が有用である
    伊藤 誉, 堀江 久永, 田原 真紀子, 森 和亮, 井上 賢之, 鯉沼 広治, 佐久間 康成, 細谷 好則, 北山 丈二, 佐田 尚宏
    日本消化器外科学会総会  2018/07  (一社)日本消化器外科学会
  • 治癒切除を受けた消化器癌術後患者へのメトホルミン内服による生存率改善について
    熊谷 祐子, 大澤 英之, 津久井 秀則, 金丸 理人, 芝 聡美, 堀江 久永, 細谷 好則, 佐久間 康成, 佐田 尚宏, 北山 丈二
    日本消化器外科学会総会  2018/07  (一社)日本消化器外科学会
  • 腹腔鏡下左側結腸癌切除に対する肥満の影響
    田原 真紀子, 堀江 久永, 森 和亮, 井上 賢之, 鯉沼 広治, 笹沼 英紀, 佐久間 康成, 細谷 好則, 北山 丈二, 佐田 尚宏
    日本消化器外科学会総会  2018/07  (一社)日本消化器外科学会
  • 膵体尾部切除術における膵断端処理と術後膵液瘻の検討
    木村 有希, 小泉 大, 三木 厚, 遠藤 和洋, 笹沼 英紀, 佐久間 康成, 堀江 久永, 細谷 好則, 北山 丈二, 佐田 尚宏
    日本消化器外科学会総会  2018/07  (一社)日本消化器外科学会
  • 当院における腹腔鏡下直腸切断術症例人工肛門造設の工夫
    巷野 佳彦, 堀江 久永, 田原 真紀子, 森 和亮, 井上 賢之, 鯉沼 広治, 佐久間 康成, 細谷 好則, 北山 丈二, 佐田 尚宏
    日本消化器外科学会総会  2018/07  (一社)日本消化器外科学会
  • 放射線化学療法(CRT)後の直腸癌組織におけるCD73の発現
    津久井 秀則, 大澤 英之, 山口 博紀, 佐久間 康成, 細谷 好則, 堀江 久永, 藤井 博文, 若月 優, 佐田 尚宏, 北山 丈二
    日本消化器外科学会総会  2018/07  (一社)日本消化器外科学会
  • 腹腔鏡下横行結腸癌手術においてSurgical trunkの郭清を安全に行うための工夫
    鯉沼 広治, 堀江 久永, 井上 賢之, 田原 真紀子, 森 和亮, 巷野 佳彦, 佐久間 康成, 細谷 好則, 北山 丈二, 佐田 尚宏
    日本消化器外科学会総会  2018/07  (一社)日本消化器外科学会
  • 上行結腸Neuroendocrine carcinomaの一例
    齋藤 匠, 鯉沼 広治, 田原 真紀子, 森 和亮, 井上 賢之, 佐久間 康成, 堀江 久永, 細谷 好則, 北山 丈二, 佐田 尚宏
    日本消化器外科学会総会  2018/07  (一社)日本消化器外科学会
  • 腹腔内液中エクソソームマイクロRNAを用いた胃癌腹膜播種症例のリキッドバイオプシー
    大澤 英之, 熊谷 祐子, 山口 博紀, 佐久間 康成, 堀江 久永, 細谷 好則, 佐田 尚宏, 北山 丈二
    日本消化器外科学会総会  2018/07  (一社)日本消化器外科学会
  • 転移巣の切除を行い長期生存が得られている直腸癌甲状腺転移の1例
    森 和亮, 鯉沼 広治, 堀江 久永, 田原 真紀子, 巷野 佳彦, 井上 賢之, 佐久間 康成, 細谷 好則, 北山 丈二, 佐田 尚宏
    日本消化器外科学会総会  2018/07  (一社)日本消化器外科学会
  • 開腹手術後の末梢血低比重好中球の臨床的意義
    熊谷 祐子, 大澤 英之, 金丸 理人, 佐久間 康成, 堀江 久永, 細谷 好則, 山口 博紀, 佐田 尚宏, 北山 丈二
    日本がん免疫学会総会プログラム・抄録集  2018/07  日本がん免疫学会
  • 春田 英律, 齋藤 心, 倉科 憲太郎, 宇井 崇, 松本 志郎, 金丸 理人, 高橋 和也, 山口 博紀, 細谷 好則, 佐久間 康成, 北山 丈二, 佐田 尚宏
    小切開・鏡視外科学会雑誌  2018/06  (NPO)小切開・鏡視外科学会
  • 上行結腸が後腹膜に固定されていない腸回転異常症を伴う絞扼性イレウスの1例
    吉田 陽, 下平 健太郎, 斎藤 心, 佐久間 康成, 堀江 久永, 細谷 好則, 北山 丈二, 佐田 尚宏
    日本臨床外科学会雑誌  2018/06  日本臨床外科学会
  • 原発性副甲状腺機能亢進症に併発した重症急性膵炎後の感染性被包化壊死の1例
    辻 賢太郎, 笠原 尚哉, 三木 厚, 遠藤 和洋, 小泉 大, 笹沼 英紀, 佐久間 康成, 堀江 久永, 細谷 好則, 北山 丈二, 佐田 尚宏
    日本臨床外科学会雑誌  2018/06  日本臨床外科学会
  • 食道神経内分泌癌(NEC)6例の治療経験  [Not invited]
    齋藤 心, 細谷 好則, 藤井 博文, 山口 博紀, 森 美鈴, 福嶋 敬宜, 金丸 理人, 松本 志郎, 三浦 義正, 佐田 尚宏
    日本食道学会学術集会プログラム・抄録集  2018/06  (NPO)日本食道学会
  • 齋藤 匠, 笹沼 英紀, 田口 昌延, 三木 厚, 遠藤 和洋, 小泉 大, 佐久間 康成, 堀江 久永, 細谷 好則, 北山 丈二, 佐田 尚宏
    膵臓  2018/05  (一社)日本膵臓学会
  • 泉 遼, 遠藤 和洋, 斉藤 晶, 田口 昌延, 三木 厚, 小泉 大, 笹沼 英紀, 佐久間 康成, 堀江 久永, 細谷 好則, 北山 丈二, 佐田 尚宏
    膵臓  2018/05  (一社)日本膵臓学会
  • 三木 厚, 佐久間 康成, 斉藤 晶, 目黒 由行, 遠藤 和洋, 小泉 大, 笹沼 英紀, 堀江 久永, 細谷 好則, 北山 丈二, 佐田 尚宏
    膵臓  2018/05  (一社)日本膵臓学会
  • 慢性特発性偽性腸閉塞症に発症した結腸二重癌の1例
    関口 裕美, 太白 健一, 堀江 久永, 直井 大志, 巷野 佳彦, 田原 真紀子, 森本 光昭, 鯉沼 広治, 佐久間 康成, 細谷 好則, 北山 丈二, 佐田 尚宏
    日本臨床外科学会雑誌  2018/05  日本臨床外科学会
  • 笹沼 英紀, 佐田 尚宏, 田口 昌延, 三木 厚, 遠藤 和洋, 小泉 大, 佐久間 康成
    膵臓  2018/05  (一社)日本膵臓学会
  • 小泉 大, 斎藤 晶, 目黒 由行, 宮戸 秀世, 田口 昌延, 兼田 裕司, 三木 厚, 遠藤 和洋, 笹沼 英紀, 佐久間 康成, 佐田 尚宏
    膵臓  2018/05  (一社)日本膵臓学会
  • 胃癌腹膜播種に対する腹腔内化学療法における腹腔洗浄液中CEA mRNA定量 手術適応決定のバイオマーカーとしての意義
    山口 博紀, 石神 浩徳, 金丸 理人, 大澤 英之, 松本 志郎, 倉科 憲太郎, 春田 英律, 細谷 好則, 北山 丈二, 佐田 尚宏
    日本外科学会定期学術集会抄録集  2018/04  (一社)日本外科学会
  • 当院におけるCrohn病に対するKono-S吻合の短期成績
    森 和亮, 堀江 久永, 太田 学, 宮原 悠三, 津久井 秀則, 太白 健一, 熊谷 祐子, 東條 峰之, 佐田友 藍, 直井 大志, 田原 真紀子, 巷野 佳彦, 伊藤 誉, 森本 光昭, 井上 賢之, 丸山 博行, 鯉沼 広治, 佐久間 康成, 細谷 好則, 北山 丈二, 佐田 尚宏
    日本外科学会定期学術集会抄録集  2018/04  (一社)日本外科学会
  • 直腸癌術前化学放射線療法における治療前後末梢血好中球リンパ球による治療効果予測
    津久井 秀則, 北山 丈二, 森本 光昭, 熊谷 祐子, 佐田友 藍, 清水 徹一郎, 直井 大志, 田原 真紀子, 巷野 佳彦, 森 和亮, 伊藤 誉, 井上 賢之, 鯉沼 広治, 佐久間 康成, 細谷 好則, 堀江 久永, Lefor Alan, 佐田 尚宏
    日本外科学会定期学術集会抄録集  2018/04  (一社)日本外科学会
  • 待機的直腸癌前方切除症例におけるERAS導入の効果
    巷野 佳彦, 堀江 久永, 津久井 秀則, 熊谷 祐子, 佐田友 藍, 直井 大志, 田原 真紀子, 伊藤 誉, 井上 賢之, 森本 光昭, 鯉沼 広治, 佐久間 康成, 細谷 好則, 北山 丈二, 佐田 尚宏
    日本外科学会定期学術集会抄録集  2018/04  (一社)日本外科学会
  • 消化器癌手術患者における末梢血中低比重好中球(Low Density Granulocyte)の術中推移
    熊谷 祐子, 金丸 理人, 津久井 秀則, 大澤 英之, 倉科 憲太郎, 鯉沼 広治, 佐久間 康成, 堀江 久永, 細谷 好則, 佐田 尚宏, 北山 丈二
    日本外科学会定期学術集会抄録集  2018/04  (一社)日本外科学会
  • 膵頭十二指腸切除術を施行した十二指腸乳頭部癌の長期成績
    小泉 大, 斎藤 晶, 横田 真一郎, 兼田 裕司, 三木 厚, 遠藤 和洋, 笹沼 英紀, 佐久間 康成, 堀江 久永, 細谷 好則, 北山 丈二, 佐田 尚宏
    日本外科学会定期学術集会抄録集  2018/04  (一社)日本外科学会
  • 腸重積症手術例の検討
    松本 健司, 小泉 大, 佐久間 康成, 細谷 好則, 堀江 久永, 北山 丈二, 佐田 尚宏
    日本外科学会定期学術集会抄録集  2018/04  (一社)日本外科学会
  • 拡大肝切除後合併症のリスクファクターの検討
    三木 厚, 佐久間 康成, 遠藤 和洋, 小泉 大, 笹沼 英紀, 堀江 久永, 細谷 好則, 北山 丈二, 佐田 尚宏
    日本外科学会定期学術集会抄録集  2018/04  (一社)日本外科学会
  • 肝肺転移を伴う大腸癌における転移出現時期からみた外科治療の意義
    佐田友 藍, 鯉沼 広治, 堀江 久永, 熊谷 祐子, 田原 真紀子, 森 和亮, 井上 賢之, 佐久間 康成, 細谷 好則, 北山 丈二, 手塚 憲志, 遠藤 俊輔, 佐田 尚宏
    日本外科学会定期学術集会抄録集  2018/04  (一社)日本外科学会
  • 待機的腹部手術後肺合併症の予測因子の検討(単施設前向きコホート研究) 簡易問診及び身体所見は肺機能検査を越えられるか?
    横田 真一郎, 小泉 大, 森本 光昭, 冨樫 一智, 佐久間 康成, 堀江 久永, 細谷 好則, 北山 丈二, 安田 是和, Lefor Alan, 佐田 尚宏
    日本外科学会定期学術集会抄録集  2018/04  (一社)日本外科学会
  • 胃癌腹膜播種治療におけるバイオマーカーとしての腹水中エクソソームマイクロRNA
    大澤 英之, 熊谷 祐子, 山口 博紀, 佐久間 康成, 堀江 久永, 細谷 好則, 佐田 尚宏, 北山 丈二
    日本外科学会定期学術集会抄録集  2018/04  (一社)日本外科学会
  • 女性外科医の働き方と当科の取り組み
    田原 真紀子, 堀江 久永, 熊谷 祐子, 佐田友 藍, 森 和亮, 井上 賢之, 小泉 大, 鯉沼 広治, 笹沼 英紀, 佐久間 康成, 細谷 好則, 北山 丈二, 佐田 尚宏
    日本外科学会定期学術集会抄録集  2018/04  (一社)日本外科学会
  • 上部空腸憩室穿孔による急性汎発性腹膜炎の1例  [Not invited]
    齋藤 俊祐, 利府 数馬, 三木 厚, 遠藤 和洋, 小泉 大, 笹沼 英紀, 佐久間 康成, 細谷 好則, 堀江 久永, 北山 丈二, 佐田 尚宏
    日本臨床外科学会雑誌  2018/03  日本臨床外科学会
  • 胃癌切除症例における術前D-dimer値と病期・転帰の検討
    倉科 憲太郎, 細谷 好則, 清水 徹一郎, 太田 学, 齋藤 心, 春田 英律, 宇井 崇, 松本 志郎, 金丸 理人, 三木 厚, 山口 博紀, 堀江 久永, 佐久間 康成, 北山 丈二, 佐田 尚宏
    日本胃癌学会総会記事  2018/03  (一社)日本胃癌学会
  • 当院における漿膜浸潤胃癌R0切除症例における術中出血量と生命予後の関係
    金丸 理人, 大澤 英之, 高橋 和也, 松本 志郎, 宇井 崇, 春田 英律, 倉科 憲太郎, 宮戸 秀世, 斉藤 心, 山口 博紀, 佐久間 康成, 堀江 久永, 細谷 好則, 佐田 尚宏, 北山 丈二
    日本胃癌学会総会記事  2018/03  (一社)日本胃癌学会
  • 腹腔内投与併用化学療法により病理学的完全奏功を得た腹膜播種陽性胃癌の2例(pCR in P1 gastric cancer using intraperitoneal and systemic chemotherapy: Report of two patients)
    目黒 由行, 山口 博紀, 北山 丈二, 石神 浩徳, 奥野 貴之, 金丸 理人, 松本 志郎, 宇井 崇, 春田 英律, 倉科 憲太郎, 齋藤 心, 細谷 好則, 佐田 尚宏
    日本胃癌学会総会記事  2018/03  (一社)日本胃癌学会
  • 胃切除後胆道結石症の検討(Biliary tract stone after gastrectomy)
    木村 有希, 細谷 好則, 小泉 大, 金丸 理人, 松本 史郎, 春田 英律, 宇井 崇, 倉科 健太郎, 宮戸 秀世, 齋藤 心, 佐久間 康成, 山口 博紀, 堀江 久永, 北山 丈二, アラン・レフォー, 佐田 尚宏
    日本胃癌学会総会記事  2018/03  (一社)日本胃癌学会
  • 胃癌腹膜播種治療における腹腔内液中エクソソームマイクロRNA解析
    大澤 英之, 熊谷 裕子, 山口 博紀, 佐久間 康成, 堀江 久永, 細谷 好則, 佐田 尚宏, 北山 丈二
    日本消化器病学会雑誌  2018/03  (一財)日本消化器病学会
  • 大腿ヘルニア嵌頓から胃壁内気腫症を来たし、4回の開腹手術により救命した1例
    松本 健司, 森 和亮, 松本 志郎, 春田 英律, 倉科 憲太郎, 佐久間 康成, 堀江 久永, 細谷 好則, 北山 丈二, 佐田 尚宏
    日本消化管学会雑誌  2018/02  (一社)日本消化管学会
  • 当科で経験した特発性上腸間膜静脈血栓症(SMVT)の7例
    森 和亮, 宮戸 英世, 斉藤 匠, 鯉沼 広治, 佐久間 康成, 堀江 久永, 細谷 好則, 北山 丈二, 佐田 尚宏
    日本腹部救急医学会雑誌  2018/02  (一社)日本腹部救急医学会
  • 保存的治療で軽快した特発性気腹症・腸管気腫症の1例
    小泉 大, 扇原 香澄, 下平 健太郎, 田中 裕美子, 櫻木 雅子, 佐久間 康成, 堀江 久永, 細谷 好則, 北山 丈二, 佐田 尚宏
    日本腹部救急医学会雑誌  2018/02  (一社)日本腹部救急医学会
  • 当院における高度肥満症に対する腹腔鏡下スリーブ状胃切除術の治療成績
    春田 英律, 細谷 好則, 岡田 健太, 倉科 憲太郎, 齋藤 心, 宇井 崇, 松本 志郎, 高橋 和也, 佐久間 康成, 堀江 久永, 北山 丈二, 佐田 尚宏
    日本成人病(生活習慣病)学会会誌  2018/01  日本成人病(生活習慣病)学会
  • 大学病院における経皮内視鏡的胃瘻造設術の適応と早期合併症
    倉科 憲太郎, 細谷 好則, 齋藤 心, 春田 英律, 宇井 崇, 松本 志郎, 金丸 理人, 安部 望, 高橋 和也, 山口 博紀, 堀江 久永, 佐久間 康成, 北山 丈二, 佐田 尚宏
    日本成人病(生活習慣病)学会会誌  2018/01  日本成人病(生活習慣病)学会
  • 画像上、類似の所見を示した胃平滑筋腫と腹壁顆粒細胞腫を合併した1症例
    齋藤 心, 春田 英律, 松本 志郎, 倉科 憲太郎, 宇井 崇, 細谷 好則, 佐久間 康成, 堀江 久永, 北山 丈二, 佐田 尚宏
    日本内視鏡外科学会雑誌  2017/12  (一社)日本内視鏡外科学会
  • 腹腔鏡下胃全摘術におけるEEA Orvilを用いた食道空腸吻合の工夫
    倉科 憲太郎, 細谷 好則, 春田 英律, 松本 志郎, 齋藤 心, 宇井 崇, 宮戸 秀世, 堀江 久永, 佐久間 康成, 北山 丈二, 佐田 尚宏
    日本内視鏡外科学会雑誌  2017/12  (一社)日本内視鏡外科学会
  • 小児GISTに対し、非穿孔式内視鏡的胃壁内反切除術を行った一例
    松本 志郎, 細谷 好則, 春田 英律, 宇井 崇, 倉科 憲太郎, 宮戸 英世, 齋藤 心, 佐久間 康成, 堀江 久永, 北山 丈二, 佐田 尚宏
    日本内視鏡外科学会雑誌  2017/12  (一社)日本内視鏡外科学会
  • 当科における腹腔鏡下スリーブ状胃切除術の手技の定型化と工夫
    春田 英律, 細谷 好則, 倉科 憲太郎, 齋藤 心, 宇井 崇, 松本 志郎, 佐久間 康成, 堀江 久永, 北山 丈二, 佐田 尚宏
    日本内視鏡外科学会雑誌  2017/12  (一社)日本内視鏡外科学会
  • 腹腔鏡下側方リンパ節郭清を安全に導入するための工夫
    堀江 久永, 鯉沼 広治, 伊藤 誉, 直井 大志, 井上 賢之, 森 克亮, 東條 峰之, 佐田友 藍, 森本 光昭, 田原 真紀子, 巷野 佳彦, 佐久間 康成, 細谷 好則, 北山 丈二, 佐田 尚宏
    日本内視鏡外科学会雑誌  2017/12  (一社)日本内視鏡外科学会
  • 腹腔鏡下直腸切断術症例の合併症予防の工夫
    巷野 佳彦, 堀江 久永, 佐田友 藍, 森 和亮, 井上 賢之, 田原 真紀子, 伊藤 誉, 森本 光昭, 直井 大志, 鯉沼 広治, 佐久間 康成, 細谷 好則, 北山 丈二, 佐田 尚宏
    日本内視鏡外科学会雑誌  2017/12  (一社)日本内視鏡外科学会
  • 当施設における腹腔鏡補助下低位前方切除術時の解剖の理解と解説
    森本 光昭, 堀江 久永, 伊藤 誉, 森 和亮, 田原 真紀子, 巷野 佳彦, 直井 大志, 井上 賢之, 鯉沼 広治, 佐久間 康成, 北山 丈二, 細谷 好則, 佐田 尚宏
    日本内視鏡外科学会雑誌  2017/12  (一社)日本内視鏡外科学会
  • 当科における腹腔鏡下直腸切断術の術後短期成績の検討
    田原 真紀子, 堀江 久永, 佐田友 藍, 直井 大志, 巷野 佳彦, 森 和亮, 伊藤 誉, 井上 賢之, 森本 光昭, 鯉沼 広治, 佐久間 康成, 細谷 好則, 北山 丈二, 佐田 尚宏
    日本内視鏡外科学会雑誌  2017/12  (一社)日本内視鏡外科学会
  • 腹腔鏡補助下S状結腸切除術後腸間膜欠損部への内ヘルニアによる絞扼性イレウスの1例
    直井 大志, 堀江 久永, 鯉沼 広治, 佐田友 藍, 田原 真紀子, 巷野 佳彦, 森 和亮, 伊藤 誉, 井上 賢之, 森本 光昭, 佐久間 康成, 細谷 好則, 北山 丈二, 佐田 尚宏
    日本内視鏡外科学会雑誌  2017/12  (一社)日本内視鏡外科学会
  • 仮想モデル、3次元プリンターモデル、高質感臓器モデルを用いた段階的手術シミュレーション教育
    遠藤 和洋, 太白 健一, 佐久間 康成, 堀江 久永, 細谷 好則, 北山 丈二, 佐田 尚宏
    日本内視鏡外科学会雑誌  2017/12  (一社)日本内視鏡外科学会
  • 安全な横行結腸癌に対する腹腔鏡下手術に向けての工夫
    鯉沼 広治, 堀江 久永, 井上 賢之, 森 和亮, 田原 真紀子, 直井 大志, 森本 光昭, 巷野 佳彦, 東條 峰之, 佐久間 康成, 細谷 好則, 北山 丈二, 佐田 尚宏
    日本内視鏡外科学会雑誌  2017/12  (一社)日本内視鏡外科学会
  • 腹腔鏡下膵体尾部切除における電動式自動縫合器を使った膵離断定型化の試み  [Not invited]
    笹沼 英紀, 佐久間 康成, 兼田 裕司, 三木 厚, 遠藤 和洋, 小泉 大, 堀江 久永, 細谷 好則, 北山 丈二, 佐田 尚宏
    日本内視鏡外科学会雑誌  2017/12  (一社)日本内視鏡外科学会
  • 手術既往のある腹腔鏡下肝切除術症例に対する妥当性の検討  [Not invited]
    谷口 理丈, 佐久間 康成, 小泉 大, 笹沼 英紀, 堀江 久永, 細谷 好則, 北山 丈二, 佐田 尚宏
    日本内視鏡外科学会雑誌  2017/12  (一社)日本内視鏡外科学会
  • 腹腔鏡下膵体尾部切除における電動式自動縫合器を使った膵離断定型化の試み  [Not invited]
    笹沼 英紀, 佐久間 康成, 兼田 裕司, 三木 厚, 遠藤 和洋, 小泉 大, 堀江 久永, 細谷 好則, 北山 丈二, 佐田 尚宏
    日本内視鏡外科学会雑誌  2017/12  (一社)日本内視鏡外科学会
  • 手術既往のある腹腔鏡下肝切除術症例に対する妥当性の検討  [Not invited]
    谷口 理丈, 佐久間 康成, 小泉 大, 笹沼 英紀, 堀江 久永, 細谷 好則, 北山 丈二, 佐田 尚宏
    日本内視鏡外科学会雑誌  2017/12  (一社)日本内視鏡外科学会
  • Nuck管水腫との鑑別を要し腹腔鏡下に診断した大腿ヘルニアの1例  [Not invited]
    金子 勇貴, 齋藤 心, 風當 ゆりえ, 巷野 佳彦, 佐田 尚宏
    日本内視鏡外科学会雑誌  2017/12  (一社)日本内視鏡外科学会
  • 術前(化学)放射線療法が直腸切断術の術後短期成績に与える影響
    田原 真紀子, 堀江 久永, 津久井 秀則, 清水 徹一郎, 直井 大志, 巷野 佳彦, 丸山 博之, 伊藤 誉, 井上 賢之, 森本 光昭, 鯉沼 広治, 佐久間 康成, 細谷 好則, 北山 丈二, 佐田 尚宏
    日本臨床外科学会雑誌  2017/10  日本臨床外科学会
  • 胆管癌間質におけるmatriptase発現とその臨床的意義
    小松原 利英, 福嶋 敬宜, 大城 久, 佐田 尚宏, 佐久間 康成
    日本消化器外科学会雑誌  2017/10  (一社)日本消化器外科学会
  • 食道癌の副腎転移と鑑別を要した副腎black adenomaの一例
    吉田 陽, 松本 志郎, 春田 英律, 倉科 憲太郎, 山口 博紀, 佐久間 康成, 堀江 久永, 細谷 好則, 北山 丈二, 佐田 尚宏
    日本臨床外科学会雑誌  2017/10  日本臨床外科学会
  • 食道癌の脳転移再発に対して手術および放射線療法で長期生存が得られた一例
    松本 志郎, 細谷 好則, 春田 英律, 倉科 憲太郎, 宮戸 英世, 山口 博紀, 佐久間 康成, 堀江 久永, 北山 丈二, 佐田 尚宏
    日本臨床外科学会雑誌  2017/10  日本臨床外科学会
  • 腹腔鏡下胃全摘術におけるEEA Orvilを用いた食道空腸吻合の工夫
    倉科 憲太郎, 細谷 好則, 春田 英律, 松本 志郎, 齋藤 心, 宇井 崇, 宮戸 秀世, 堀江 久永, 佐久間 康成, 山口 博紀, 北山 丈二, 佐田 尚宏
    日本臨床外科学会雑誌  2017/10  日本臨床外科学会
  • 膵頭十二指腸切除での再建の工夫 Blumgart変法(自治医大方式)による膵空腸吻合の成績  [Not invited]
    小泉 大, 斎藤 晶, 兼田 裕司, 三木 厚, 遠藤 和洋, 笹沼 英紀, 佐久間 康成, 堀江 久永, 細谷 好則, 北山 丈二, 佐田 尚宏
    日本臨床外科学会雑誌  2017/10  日本臨床外科学会
  • 細谷 好則, 春田 英律, 田口 昌延, 斉藤 心, 倉科 憲太郎, 松本 志郎, 岡田 健太, 海老原 健, 石橋 俊, 矢田 俊彦, 北山 丈二, 佐田 尚宏
    肥満研究  2017/09  (一社)日本肥満学会
  • 田口 昌延, 出崎 克也, 佐田 尚宏, 細谷 好則, 矢田 俊彦
    肥満研究  2017/09  (一社)日本肥満学会
  • 当科における直腸切断術症例の術後合併症について
    巷野 佳彦, 堀江 久永, 津久井 秀則, 佐田友 藍, 森 和亮, 東條 峰之, 井上 賢之, 熊谷 祐子, 宮原 悠三, 太白 健一, 田原 真紀子, 伊藤 誉, 清水 徹一郎, 丸山 博行, 森本 光昭, 直井 大志, 鯉沼 広治, 北山 丈二, 佐田 尚宏
    日本大腸肛門病学会雑誌  2017/09  (一社)日本大腸肛門病学会
  • 直腸癌超低位前方切除5年後に発症した直腸腟瘻に対しMartius flap法にて修復した1例
    井上 賢之, 堀江 久永, 浜畑 幸弘, 太白 健一, 熊谷 祐子, 東條 峰之, 佐田友 藍, 清水 徹一郎, 直井 大志, 田原 真紀子, 森 和亮, 巷野 佳彦, 伊藤 誉, 森本 光昭, 丸山 博行, 鯉沼 広治, 佐久間 康成, 細谷 好則, 北山 丈二, 佐田 尚宏
    日本大腸肛門病学会雑誌  2017/09  (一社)日本大腸肛門病学会
  • 直腸癌術後に孤発性の右拇指中手骨転移を来した1例
    伊藤 誉, 堀江 久永, 直井 大志, 井上 賢之, 森本 光昭, 鯉沼 広治, 佐久間 康成, 細谷 好則, 北山 丈二, 佐田 尚宏
    日本大腸肛門病学会雑誌  2017/09  (一社)日本大腸肛門病学会
  • 当院におけるCrohn病に対するKono-S吻合の短期成績
    森 和亮, 直井 大志, 鯉沼 広治, 堀江 久永, 津久井 秀則, 太白 健一, 熊谷 祐子, 東條 峰之, 佐田友 藍, 清水 徹一郎, 田原 真紀子, 巷野 佳彦, 伊藤 誉, 森本 光昭, 井上 賢之, 丸山 博行, 佐久間 康成, 細谷 好則, 北山 丈二, 佐田 尚宏
    日本大腸肛門病学会雑誌  2017/09  (一社)日本大腸肛門病学会
  • 当科における小腸ストーマ造設後high-output stoma症例の検討
    直井 大志, 堀江 久永, 鯉沼 広治, 津久井 秀則, 太白 健一, 宮原 悠三, 熊谷 祐子, 東條 峰之, 佐田友 藍, 清水 徹一郎, 巷野 佳彦, 森 和亮, 伊藤 誉, 田原 真紀子, 森本 光昭, 井上 賢之, 丸山 博之, 北山 丈二, 佐田 尚宏
    日本大腸肛門病学会雑誌  2017/09  (一社)日本大腸肛門病学会
  • 当科における下部進行直腸癌に対する術前放射線化学療法後の腹腔鏡手術の短期成績と導入の安全性について
    森本 光昭, 堀江 久永, 鯉沼 広治, 井上 賢之, 伊藤 誉, 森 和亮, 清水 徹一郎, 巷野 佳彦, 田原 真紀子, 直井 大志, 佐田友 藍, 東條 峰之, 熊谷 祐子, 津久井 秀則, 宮原 悠三, 佐田 尚宏
    日本大腸肛門病学会雑誌  2017/09  (一社)日本大腸肛門病学会
  • 開腹術後の腹膜再発における腹腔滲出性低比重好中球の意義
    北山 丈二, 金丸 理人, 津久井 秀則, 大澤 英之, 山口 博紀, 松本 志朗, 倉科 憲太郎, 宮戸 秀世, 細谷 好則, 佐田 尚宏
    日本癌学会総会記事  2017/09  日本癌学会
  • 胃癌腹膜播種治療におけるバイオマーカーとしての腹水中エクソソームマイクロRNA解析
    大澤 英之, 三木 厚, 山口 博紀, 佐久間 康成, 堀江 久永, 細谷 好則, 北山 丈二, 佐田 尚宏
    日本癌学会総会記事  2017/09  日本癌学会
  • 生体肝移植ドナーの左外側区域切除後にS4肝膿瘍を合併した一例
    大豆生田 尚彦, 眞田 幸弘, 佐久間 康成, 片野 匠, 平田 雄大, 山田 直也, 岡田 憲樹, 井原 欣幸, 浦橋 泰然, 佐田 尚宏, 水田 耕一
    移植  2017/08  (一社)日本移植学会
  • 周術期を支える漢方を科学する! その基礎と臨床 胃全摘後の摂食低下・体重減少とTJ-43六君子湯による改善及び新規メカニズムの発見
    田口 昌延, 出崎 克也, 小泉 大, 倉科 憲太郎, 細谷 好則, Lefor Alan, 堀江 久永, 北山 丈二, 佐田 尚宏, 矢田 俊彦
    日本消化器外科学会総会  2017/07  (一社)日本消化器外科学会
  • 高度進行胃癌でのresectable metastasisに対する治療戦略 胃癌腹膜播種、腹腔内投与併用化学療法奏効例におけるConversion Surgery
    山口 博紀, 石神 浩徳, 齋藤 心, 倉科 憲太郎, 大澤 英之, 松本 志郎, 藤井 博文, 細谷 好則, 北山 丈二, 佐田 尚宏
    日本消化器外科学会総会  2017/07  (一社)日本消化器外科学会
  • 胃癌術後腹腔内Neutrophil Extracellular Traps(NETs)の腹膜播種再発の関与について
    金丸 理人, 津久井 秀則, 斉藤 心, 倉科 憲太郎, 松本 志郎, 山口 博紀, 堀江 久永, 細谷 好則, 佐田 尚宏, 北山 丈二
    日本消化器外科学会総会  2017/07  (一社)日本消化器外科学会
  • 消化器外科の診断・手技・治療に役立つ先進技術 腹腔鏡下側方リンパ節郭清に役立つ術前シミュレーション
    堀江 久永, 鯉沼 広治, 伊藤 誉, 直井 大志, 井上 賢之, Lefor Alan, 佐久間 康成, 細谷 好則, 北山 丈二, 佐田 尚宏
    日本消化器外科学会総会  2017/07  (一社)日本消化器外科学会
  • 左側大腸癌イレウスに対する経肛門イレウス管の適応と限界
    井上 賢之, 堀江 久永, 直井 大志, 伊藤 誉, 森本 光昭, 鯉沼 広治, 細谷 好則, 北山 丈二, Lefor Alan, 佐田 尚宏
    日本消化器外科学会総会  2017/07  (一社)日本消化器外科学会
  • 閉鎖孔ヘルニア嵌頓症例の臨床的検討
    金子 勇貴, 小泉 大, 下平 健太郎, 井上 賢之, 齋藤 心, 佐久間 康成, 堀江 久永, 細谷 好則, 北山 丈二, 佐田 尚宏
    日本消化器外科学会総会  2017/07  (一社)日本消化器外科学会
  • 消化器癌の診断・治療を含めた新規分子腫瘍マーカーの意義と展望 胃癌腹膜播種治療における腹腔内液中バイオマーカーの意義
    北山 丈二, 山口 博紀, 石神 浩則, 大澤 英之, 細谷 好則, 山下 裕玄, 瀬戸 泰之, 佐田 尚宏
    日本消化器外科学会総会  2017/07  (一社)日本消化器外科学会
  • 局所進行直腸癌に対する集学的治療戦略 術前化学放射線療法(CRT)を行った下部進行直腸癌症例の術後3ヵ月内のCEA値は予後を予測しうるか
    森本 光昭, 堀江 久永, 直井 大志, 鯉沼 広治, 仲澤 聖則, 佐久間 康成, 細谷 好則, 北山 丈二, Lefor Alan, 佐田 尚宏
    日本消化器外科学会総会  2017/07  (一社)日本消化器外科学会
  • 消化器外科における術後回復促進策(ERAS) 直腸癌待機的前方切除症例におけるERAS導入の効果
    巷野 佳彦, 堀江 久永, 直井 大志, 井上 賢之, 森本 光昭, 鯉沼 広治, 細谷 好則, Lefor Alan, 北山 丈二, 佐田 尚宏
    日本消化器外科学会総会  2017/07  (一社)日本消化器外科学会
  • 消化器外科の診断・手技・治療に役立つ先進技術 非視覚的主体情報の統合した、マクロ・ミクロをカバーする4K/8K対応・内視鏡手術システムの開発
    遠藤 和洋, 太白 健一, 直井 大志, 佐久間 康成, 堀江 久永, 細谷 好則, アラン・レフォー, 北山 丈二, 佐田 尚宏
    日本消化器外科学会総会  2017/07  (一社)日本消化器外科学会
  • 横行結腸癌に対する安全な腹腔鏡下Complete Mesocolic Excisionの工夫
    鯉沼 広治, 堀江 久永, 直井 大志, 井上 賢之, 田原 真紀子, 森本 光昭, 佐久間 康成, 細谷 好則, 北山 丈二, 佐田 尚宏
    日本消化器外科学会総会  2017/07  (一社)日本消化器外科学会
  • 当科における虫垂腫瘍の臨床病理学的検討
    谷口 理丈, 鯉沼 広治, 堀江 久永, 直井 大志, 井上 賢之, 森本 光昭, 佐久間 康成, 細谷 好則, 北山 丈二, 佐田 尚宏
    日本消化器外科学会総会  2017/07  (一社)日本消化器外科学会
  • 乳癌手術におけるPONV(術後悪心・嘔吐)発生の検討 デキサメタゾンの予防投与は有効か?
    櫻木 雅子, 平 幸輝, 田中 裕美子, 芝 聡美, 宮崎 千絵子, 塩澤 幹雄, 竹内 護, 藤田 崇史, 穂積 康夫, 佐田 尚宏, 興梠 貴英, 三重野 牧子, 水沼 洋文
    日本乳癌学会総会プログラム抄録集  2017/07  (一社)日本乳癌学会
  • Blumgart-dumpling法(Blumgart変法 自治医大方式)による膵空腸吻合の工夫  [Not invited]
    小泉 大, 笠原 尚哉, 三木 厚, 遠藤 和洋, 笹沼 英紀, 佐久間 康成, 堀江 久永, 細谷 好則, 北山 丈二, 佐田 尚宏
    日本消化器外科学会総会  2017/07  (一社)日本消化器外科学会
  • 切除可能膵癌に対する術前治療戦略の意義 切除可能膵癌に対する術前化学放射線治療の有用性  [Not invited]
    三木 厚, 佐久間 康成, 笠原 尚哉, 遠藤 和洋, 小泉 大, 笹沼 英紀, 堀江 久永, 細谷 好則, 北山 丈二, 佐田 尚宏
    日本消化器外科学会総会  2017/07  (一社)日本消化器外科学会
  • 退形成性膵管癌の6切除例  [Not invited]
    風當 ゆりえ, 三木 厚, 遠藤 和洋, 小泉 大, 笹沼 英紀, 佐久間 康成, 堀江 久永, 細谷 好則, 北山 丈二, 佐田 尚宏
    日本消化器外科学会総会  2017/07  (一社)日本消化器外科学会
  • 当科における膵IPMNの縮小手術の検討  [Not invited]
    齋藤 匠, 三木 厚, 遠藤 和洋, 小泉 大, 笹沼 英紀, 佐久間 康成, 堀江 久永, 細谷 好則, 北山 丈二, 佐田 尚宏
    日本消化器外科学会総会  2017/07  (一社)日本消化器外科学会
  • 胃切除後の胆道結石症の検討  [Not invited]
    木村 有希, 小泉 大, 三木 厚, 遠藤 和洋, 笹沼 英紀, 佐久間 康成, 細谷 好則, 北山 丈二, 佐田 尚宏
    日本消化器外科学会総会  2017/07  (一社)日本消化器外科学会
  • Blumgart-dumpling法(Blumgart変法 自治医大方式)による膵空腸吻合の工夫  [Not invited]
    小泉 大, 笠原 尚哉, 三木 厚, 遠藤 和洋, 笹沼 英紀, 佐久間 康成, 堀江 久永, 細谷 好則, 北山 丈二, 佐田 尚宏
    日本消化器外科学会総会  2017/07  (一社)日本消化器外科学会
  • 切除可能膵癌に対する術前治療戦略の意義 切除可能膵癌に対する術前化学放射線治療の有用性  [Not invited]
    三木 厚, 佐久間 康成, 笠原 尚哉, 遠藤 和洋, 小泉 大, 笹沼 英紀, 堀江 久永, 細谷 好則, 北山 丈二, 佐田 尚宏
    日本消化器外科学会総会  2017/07  (一社)日本消化器外科学会
  • 十二指腸腫瘍性病変に対する膵温存十二指腸切除術の治療成績  [Not invited]
    齋藤 晶, 小泉 大, 三木 厚, 遠藤 和洋, 笹沼 英紀, 佐久間 康成, 堀江 久永, 細谷 好則, 北山 丈二, 佐田 尚宏
    日本消化器外科学会総会  2017/07  (一社)日本消化器外科学会
  • 当院における腹腔鏡下スリーブ状胃切除術の治療成績
    春田 英律, 細谷 好則, 松本 志郎, 齋藤 心, 倉科 憲太郎, 宇井 崇, 安部 望, 金丸 理人, 高橋 和也, 北山 丈二, 佐久間 康成, 堀江 久永, 海老原 健, 石橋 俊, 佐田 尚宏
    日本肥満症治療学会学術集会プログラム・抄録集  2017/06  日本肥満症治療学会
  • 漏斗胸を伴う胸部下部食道癌に対して食道亜全摘、胸骨前胃管再建術を施行した1例
    高橋 大二郎, 斎藤 心, 宇井 崇, 倉科 憲太郎, 細谷 好則, 北山 丈二, 佐田 尚宏
    日本食道学会学術集会プログラム・抄録集  2017/06  (NPO)日本食道学会
  • 中下部進行直腸癌に対する腹腔鏡手術の短期成績
    津久井 秀則, 堀江 久永, 森本 光昭, 太白 健一, 宮原 悠三, 熊谷 祐子, 東條 峰之, 佐田友 藍, 清水 徹一郎, 直井 大志, 井上 賢之, 田原 真紀子, 巷野 佳彦, 森 和亮, 丸山 博行, 伊藤 誉, 鯉沼 広治, 佐田 尚宏
    日本大腸肛門病学会雑誌  2017/05  (一社)日本大腸肛門病学会
  • 齋藤 匠, 三木 厚, 笠原 尚哉, 遠藤 和洋, 小泉 大, 笹沼 英紀, 佐久間 康成, 堀江 久永, 細谷 好則, 北山 丈二, 佐田 尚宏
    膵臓  2017/05  (一社)日本膵臓学会
  • 腹腔鏡下ISRの治療成績
    堀江 久永, 鯉沼 広治, 津久井 秀則, 熊谷 祐子, 佐田友 藍, 清水 徹一郎, 直井 大志, 田原 真紀子, 巷野 佳彦, 森 和亮, 伊藤 誉, 井上 賢之, 森本 光昭, 佐久間 康成, 細谷 好則, 佐田 尚宏
    日本大腸肛門病学会雑誌  2017/04  (一社)日本大腸肛門病学会
  • 胃癌腹膜再発における開腹術後の腹腔内滲出液中low density granulocytes(LDG)の意義
    金丸 理人, 津久井 秀則, 斉藤 心, 倉科 憲太郎, 宇井 崇, 春田 英律, 松本 志郎, 安部 望, 高橋 和也, 山口 博紀, 佐久間 康成, 堀江 久永, 細谷 好則, 佐田 尚宏, 北山 丈二
    日本外科学会定期学術集会抄録集  2017/04  (一社)日本外科学会
  • 胃癌術後補助化学療法の新たな選択 漿膜浸潤陽性胃癌に対する補助療法としてのPaclitaxel腹腔内反復投与の可能性
    北山 丈二, 石神 浩徳, 山口 博紀, 金丸 理人, 松本 志郎, 倉科 憲太郎, 斎藤 心, 細谷 好則, 佐田 尚宏
    日本外科学会定期学術集会抄録集  2017/04  (一社)日本外科学会
  • 若手外科医に対する腹腔鏡下大腸切除トレーニングシステム
    堀江 久永, 鯉沼 広治, 津久井 秀則, 熊谷 祐子, 佐田友 藍, 清水 徹一郎, 直井 大志, 田原 真紀子, 巷野 佳彦, 森 和亮, 伊藤 誉, 井上 賢之, 森本 光昭, 佐久間 康成, 細谷 好則, 北山 丈二, 佐田 尚宏
    日本外科学会定期学術集会抄録集  2017/04  (一社)日本外科学会
  • 当院における局所進行下部直腸癌に対する術前化学放射線療法の有用性と課題について
    森本 光昭, 津久井 秀則, 熊谷 祐子, 佐田友 藍, 清水 徹一郎, 直井 大志, 田原 真紀子, 巷野 佳彦, 森 和亮, 伊藤 誉, 井上 賢之, 鯉沼 広治, 佐久間 康成, 細谷 好則, 北山 丈二, 堀江 久永, Lefor Alan, 佐田 尚宏
    日本外科学会定期学術集会抄録集  2017/04  (一社)日本外科学会
  • クローン病に対する腸管吻合におけるKono-S吻合導入後の短期成績
    直井 大志, 堀江 久永, 鯉沼 広治, 津久井 秀則, 宮原 悠三, 太白 健一, 熊谷 祐子, 東條 峰之, 佐田友 藍, 清水 徹一郎, 巷野 佳彦, 森 和亮, 丸山 博行, 伊藤 誉, 森本 光昭, 井上 賢之, 田原 真紀子, 佐久間 康成, 細谷 好則, 北山 丈二, 佐田 尚宏
    日本外科学会定期学術集会抄録集  2017/04  (一社)日本外科学会
  • 胆嚢管合流部隔壁構造に着目した胆嚢管アプローチによる総胆管結石採石法 その解剖学的基盤と実践
    清水 敦, 野田 泰子, 安田 是和, 佐久間 康成, 細谷 好則, 堀江 久永, 北山 丈二, 佐田 尚宏
    日本外科学会定期学術集会抄録集  2017/04  (一社)日本外科学会
  • 腹腔鏡下横行結腸癌手術における難易度克服への工夫
    鯉沼 広治, 堀江 久永, 森本 光昭, 井上 賢之, 直井 大志, 田原 真紀子, 巷野 佳彦, 佐久間 康成, 細谷 好則, 北山 丈二, Lefor Alan, 佐田 尚宏
    日本外科学会定期学術集会抄録集  2017/04  (一社)日本外科学会
  • デキサメタゾン投与によるPONV(術後悪心・嘔吐)予防効果についての検討
    櫻木 雅子, 平 幸輝, 田中 裕美子, 芝 聡美, 宮崎 千絵子, 井上 壮一郎, 三重野 牧子, 興梠 貴英, 藤田 崇史, 竹内 護, 佐田 尚宏
    日本外科学会定期学術集会抄録集  2017/04  (一社)日本外科学会
  • 家族性大腸腺腫症に合併した十二指腸病変の検討  [Not invited]
    木村 有希, 小泉 大, 笠原 尚哉, 三木 厚, 遠藤 和洋, 笹沼 英紀, 佐久間 康成, 堀江 久永, 細谷 好則, 北山 丈二, 佐田 尚宏
    日本外科学会定期学術集会抄録集  2017/04  (一社)日本外科学会
  • IPMN国際診療ガイドラインからみた当院でのIPMN手術例の検討  [Not invited]
    齋藤 匠, 三木 厚, 笠原 尚哉, 遠藤 和洋, 小泉 大, 笹沼 英紀, 佐久間 康成, 堀江 久永, 細谷 好則, 北山 丈二, 佐田 尚宏
    日本外科学会定期学術集会抄録集  2017/04  (一社)日本外科学会
  • 膵空腸吻合Blumgart変法(自治医大方式)に適した膵臓の検討  [Not invited]
    小泉 大, 笠原 尚哉, 三木 厚, 遠藤 和洋, 笹沼 英紀, 佐久間 康成, 堀江 久永, 細谷 好則, 北山 丈二, Lefor Alan, 佐田 尚宏
    日本外科学会定期学術集会抄録集  2017/04  (一社)日本外科学会
  • 質感と人体解剖を忠実に再現した、高難度手術教育のための臓器モデル 鏡視下手術の教育効果を高めるために必要な技術トレーニング  [Not invited]
    遠藤 和洋, 太白 健一, 笠原 尚哉, 三木 厚, 小泉 大, 笹沼 英紀, 佐久間 康成, 堀江 久永, 細谷 好則, 北山 丈二, 佐田 尚宏
    日本外科学会定期学術集会抄録集  2017/04  (一社)日本外科学会
  • 長谷川 直人, 中村 美鈴, 佐藤 幹代, 村上 礼子, 中野 真理子, 佐々木 雅史, 水口 恵美子, 渡辺 芳江, 半田 知子, 宮田 直美, 相賀 美幸, 弘田 智香, 佐田 尚宏, 細谷 好則, 倉科 憲太郎
    自治医科大学看護学ジャーナル  2017/03  自治医科大学看護学部
  • 腹腔内化学療法の経験のない施設における新規導入(Introduction of intraperitoneal chemotherapy at a hospital with inexperienced staff)
    山口 博紀, 北山 丈二, 大澤 英之, 金丸 理人, 松本 志郎, 森 美鈴, 齋藤 心, 倉科 憲太郎, 上田 真寿, 細谷 好則, 藤井 博文, 佐田 尚宏
    日本胃癌学会総会記事  2017/03  (一社)日本胃癌学会
  • 胃癌腹膜再発における開腹術後の腹腔内滲出液中low density granulocytes(LDG)の意義(Low density granulocytes in peritoneal exudates may assist peritoneal recurrence after gastrectomy)
    北山 丈二, 金丸 理人, 津久井 秀則, 松本 志郎, 倉科 憲太郎, 斎藤 心, 細谷 好則, 山口 博紀, 石神 浩徳, 佐田 尚宏
    日本胃癌学会総会記事  2017/03  (一社)日本胃癌学会
  • 胃過形成ポリープに発生した低分化型腺癌の1例(Poorly differentiated adenocarcinoma arising in hyperplastic polyp of the stomach: A report of case)
    高橋 和也, 齋藤 心, 金丸 理人, 安部 望, 松本 志郎, 宇井 崇, 春田 英律, 倉科 憲太郎, 佐久間 康成, 堀江 久永, 細谷 好則, 北山 丈二, 佐田 尚宏
    日本胃癌学会総会記事  2017/03  (一社)日本胃癌学会
  • 膵の救急疾患(外傷含む) 重症急性膵炎局所合併症に対する治療の全国実態調査  [Not invited]
    小泉 大, 佐田 尚宏, 黒河内 顕, 笹沼 英紀, 伊佐地 秀司, 糸井 隆夫, 北野 雅之, 廣田 衛久, 松本 逸平, 安田 一朗, 竹山 宜典
    日本腹部救急医学会雑誌  2017/02  日本腹部救急医学会
  • 大腸癌同時性・異時性肝転移症例の予後比較についての検討
    津久井 秀則, 森本 光昭, 堀江 久永, 田原 真紀子, 佐田友 藍, 清水 徹一郎, 直井 大志, 井上 賢之, 巷野 佳彦, 森 和亮, 伊藤 誉, 鯉沼 広治, 佐田 尚宏
    日本大腸肛門病学会雑誌  2017/02  (一社)日本大腸肛門病学会
  • 膵体尾部を中心とした左側感染性WONに対する治療戦略
    笹沼 英紀, 佐久間 康成, 笠原 尚哉, 三木 厚, 遠藤 和洋, 小泉 大, 堀江 久永, 細谷 好則, 佐田 尚宏
    日本腹部救急医学会雑誌  2017/02  (一社)日本腹部救急医学会
  • 肺気腫、低肺機能を併存した食道癌症例に対する縦隔鏡下食道切除術の1経験
    齋藤 心, 細谷 好則, 宇井 崇, 倉科 憲太郎, 春田 英律, 松本 志郎, 金丸 理人, 安部 望, 高橋 和也, 北山 丈二, 佐田 尚宏, 愛甲 丞, 瀬戸 泰之
    日本内視鏡外科学会雑誌  2016/12  (一社)日本内視鏡外科学会
  • 癒着性腸閉塞に対する気腹CTによる術前評価が有用であった2例
    直井 大志, 堀江 久永, 鯉沼 広治, 清水 徹一郎, 巷野 佳彦, 森 和亮, 丸山 博行, 伊藤 誉, 森本 光昭, 井上 賢之, 田原 真紀子, 佐久間 康成, 細谷 好則, 北山 丈二, 佐田 尚宏
    日本内視鏡外科学会雑誌  2016/12  (一社)日本内視鏡外科学会
  • 当科の腹腔鏡補助下低位前方切除術の出血時の対応と手術手技について
    森本 光昭, 堀江 久永, 津久井 秀則, 東條 峰之, 直井 大志, 井上 賢之, 田原 真紀子, 巷野 佳彦, 森 和亮, 伊藤 誉, 鯉沼 広治, 佐久間 康成, 北山 丈二, 細谷 義則, 佐田 尚宏
    日本内視鏡外科学会雑誌  2016/12  (一社)日本内視鏡外科学会
  • 腹腔鏡下側方リンパ節郭清を安全に導入するための工夫
    堀江 久永, 鯉沼 広治, 伊藤 誉, 直井 大志, 田原 真紀子, 井上 賢之, 巷野 佳彦, 津久井 秀則, 佐田友 藍, 森 和亮, 森本 光昭, 佐久間 康成, 細谷 好則, 北山 丈二, 佐田 尚宏
    日本内視鏡外科学会雑誌  2016/12  (一社)日本内視鏡外科学会
  • 腹腔鏡下直腸前方切除術症例における早期経口摂取の検討
    巷野 佳彦, 堀江 久永, 熊谷 祐子, 清水 徹一郎, 直井 大志, 田原 真紀子, 伊藤 誉, 森 和亮, 森本 光昭, 鯉沼 広治, 細谷 好則, 北山 丈二, 佐田 尚宏
    日本内視鏡外科学会雑誌  2016/12  (一社)日本内視鏡外科学会
  • 腹腔鏡下横行結腸癌手術における空間認識能向上への工夫
    鯉沼 広治, 堀江 久永, 直井 大志, 田原 真紀子, 井上 賢之, 巷野 佳彦, 森本 光昭, 丸山 博行, 森 和亮, 伊藤 誉, 佐田友 藍, 佐久間 康成, 細谷 好則, 北山 丈二, 佐田 尚宏
    日本内視鏡外科学会雑誌  2016/12  (一社)日本内視鏡外科学会
  • 医工連携による革新的内視鏡手術トレーニングシステムの開発 外科教育の新たな手法確立に向けて  [Not invited]
    遠藤 和洋, 太白 健一, 笠原 直哉, 三木 厚, 小泉 大, 笹沼 英紀, 佐久間 康成, 堀江 久永, 細谷 好則, 北山 丈二, 佐田 尚宏
    日本内視鏡外科学会雑誌  2016/12  (一社)日本内視鏡外科学会
  • 上腹部手術既往のある症例における腹腔鏡下肝切除の検討  [Not invited]
    谷口 理丈, 佐久間 康成, 森嶋 計, 笠原 尚哉, 三木 厚, 遠藤 和洋, 小泉 大, 笹沼 英紀, 佐田 尚宏
    日本内視鏡外科学会雑誌  2016/12  (一社)日本内視鏡外科学会
  • 腹腔鏡下肝切除にRFAを併用して治療した肝細胞癌4例の経験  [Not invited]
    森嶋 計, 笠原 尚哉, 三木 厚, 遠藤 和洋, 小泉 大, 笹沼 英紀, 佐久間 康成, 堀江 久永, 細谷 好則, 佐田 尚宏
    日本内視鏡外科学会雑誌  2016/12  (一社)日本内視鏡外科学会
  • 胸骨後経路胃管癌に対して鏡視下胃管切除・空腸再建を行なった1例
    平瀬 雄規, 齋藤 心, 津久井 秀則, 松本 志郎, 倉科 健太郎, 佐久間 康成, 堀江 久永, 細谷 好則, 佐田 尚宏
    日本臨床外科学会雑誌  2016/11  日本臨床外科学会
  • 直腸神経鞘腫の一例
    熊谷 祐子, 伊藤 誉, 青木 裕一, 鯉沼 広治, 堀江 久永, 佐田 尚宏
    日本臨床外科学会雑誌  2016/11  日本臨床外科学会
  • 胸骨後経路胃管癌に対して胸壁吊り上げ式鏡視下胃管切除・空腸再建を行なった3例の経験
    齋藤 心, 宇井 崇, 倉科 憲太郎, 金丸 理人, 松本 志郎, 堀江 久永, 佐久間 康成, 細谷 好則, 北山 丈二, 佐田 尚宏, 永井 秀雄, 福嶋 敬宜
    日本消化器外科学会雑誌  2016/11  (一社)日本消化器外科学会
  • 崎尾亮太郎, 三木厚, 森嶋計, 笠原尚哉, 笹沼英紀, 佐久間康成, 佐田尚宏, 安田是和
    日本臨床外科学会雑誌  2016/10
  • 木村有希, 小泉大, 笠原尚哉, 三木厚, 遠藤和洋, 笹沼英紀, 佐久間康成, 堀江久永, 細谷好則, 北山丈二, 佐田尚宏
    日本臨床外科学会雑誌  2016/10
  • 遠藤和洋, 太白健一, 笠原直哉, 三木厚, 小泉大, 笹沼英紀, 佐久間康成, 堀江久永, 細谷好則, 北山丈二, 佐田尚宏
    日本臨床外科学会雑誌  2016/10
  • 井上賢之, 金丸理人, 森嶋計, 石黒保直, 小泉大, 笹沼英紀, 佐田尚宏
    日本臨床外科学会雑誌  2016/10  日本臨床外科学会
  • 小泉大, 木村有希, 笠原尚哉, 三木厚, 遠藤和洋, 笹沼英紀, 佐久間康成, 堀江久永, 細谷好則, 北山丈二, 佐田尚宏
    日本臨床外科学会雑誌  2016/10  日本臨床外科学会
  • 当科におけるLow-grade appendiceal mucinous neoplasmの臨床病理学的検討
    谷口 理丈, 鯉沼 広治, 堀江 久永, 宮原 悠三, 津久井 秀則, 太白 健一, 熊谷 祐子, 東條 峰之, 佐田友 藍, 直井 大志, 清水 徹一郎, 田原 真紀子, 伊藤 誉, 森 和亮, 巷野 佳彦, 井上 賢之, 森本 光昭, 佐田 尚宏
    日本大腸肛門病学会雑誌  2016/10  (一社)日本大腸肛門病学会
  • 横行結腸癌手術における中結腸動脈主リンパ節のCTサイズと病理学的転移および予後との関連について
    丸山 博行, 鯉沼 広治, 堀江 久永, 太白 健一, 宮原 悠三, 津久井 秀則, 熊谷 祐子, 東條 峰之, 佐田友 藍, 清水 徹一郎, 直井 大志, 井上 賢之, 田原 真紀子, 巷野 佳彦, 森 和亮, 伊藤 誉, 森本 光昭, 北山 丈二, 佐田 尚宏
    日本大腸肛門病学会雑誌  2016/10  (一社)日本大腸肛門病学会
  • 大腸内視鏡が左鼠径ヘルニアに嵌頓し挿入困難となった2例
    伊藤 誉, 堀江 久永, 直井 大志, 田原 真紀子, 巷野 佳彦, 森本 光昭, 鯉沼 広治, 北山 丈二, 佐田 尚宏
    日本大腸肛門病学会雑誌  2016/10  (一社)日本大腸肛門病学会
  • 家族性大腸腺腫症(FAP)に対する結腸全摘・回腸直腸吻合術(IRA)の適応について
    堀江 久永, 鯉沼 広治, 津久井 秀則, 太白 健一, 宮原 悠三, 熊谷 祐子, 東條 峰之, 佐田友 藍, 清水 徹一郎, 直井 大志, 巷野 佳彦, 森 和亮, 丸山 博行, 伊藤 誉, 森本 光昭, 井上 賢之, 田原 真紀子, 北山 丈二, 佐田 尚宏
    日本大腸肛門病学会雑誌  2016/10  (一社)日本大腸肛門病学会
  • 当科の腹腔鏡補助下低位前方切除術の標準化に向けた取り組みと短期成績、手術手技について
    森本 光昭, 堀江 久永, 太白 健一, 宮原 悠三, 津久井 秀則, 熊谷 祐子, 東條 峰之, 佐田友 藍, 清水 徹一郎, 直井 大志, 井上 賢之, 田原 真紀子, 巷野 佳彦, 森 和亮, 伊藤 誉, 鯉沼 広治, 北山 丈二, 佐田 尚宏
    日本大腸肛門病学会雑誌  2016/10  (一社)日本大腸肛門病学会
  • Ra、Rb進行直腸癌に対する腹腔鏡下低位前方切除術の短期成績
    津久井 秀則, 堀江 久永, 森本 光昭, 太白 健一, 宮原 悠三, 熊谷 祐子, 東條 峰之, 佐田友 藍, 清水 徹一郎, 直井 大志, 井上 賢之, 田原 真紀子, 巷野 佳彦, 森 和亮, 丸山 博行, 伊藤 誉, 鯉沼 広治, 北山 丈二, 佐田 尚宏
    日本大腸肛門病学会雑誌  2016/10  (一社)日本大腸肛門病学会
  • 直腸癌低位前方切除術における縫合不全発生リスク因子の検討
    太白 健一, 鯉沼 広治, 堀江 久永, 宮原 悠三, 津久井 秀則, 東條 峰之, 佐田友 藍, 清水 徹一郎, 直井 大志, 井上 賢之, 田原 真紀子, 巷野 佳彦, 森 和亮, 伊藤 誉, 森本 光昭, 丸山 博行, 北山 丈二, 佐田 尚宏
    日本大腸肛門病学会雑誌  2016/10  (一社)日本大腸肛門病学会
  • 大腸外科における手術部位感染対策 当科における周術期SSI対策変更による術後SSIへの影響
    直井 大志, 堀江 久永, 鯉沼 広治, 津久井 秀則, 太白 健一, 宮原 悠三, 熊谷 祐子, 東條 峰之, 佐田友 藍, 清水 徹一郎, 巷野 佳彦, 森 和亮, 丸山 博行, 伊藤 誉, 森本 光昭, 井上 賢之, 田原 真紀子, 北山 丈二, 佐田 尚宏
    日本大腸肛門病学会雑誌  2016/10  (一社)日本大腸肛門病学会
  • 直腸脱 病態から考える術式選択 当院における腹腔鏡下後方固定術の手術成績
    森本 光昭, 堀江 久永, 太白 健一, 津久井 秀則, 熊谷 祐子, 東條 峰之, 佐田友 藍, 清水 徹一郎, 直井 大志, 井上 賢之, 田原 真紀子, 巷野 佳彦, 伊藤 誉, 鯉沼 広治, 佐田 尚宏
    日本臨床外科学会雑誌  2016/10  日本臨床外科学会
  • 川口 英之, 小泉 大, 佐久間 康成, 堀江 久永, 細谷 好則, 北山 丈二, 佐田 尚宏
    日本外科感染症学会雑誌  2016/10  (一社)日本外科感染症学会
  • 子宮摘出術3ヵ月後に腟断端離開、小腸脱出した一例
    扇原 香澄, 遠藤 和洋, 佐久間 康成, 堀江 久永, 細谷 好則, 北山 丈二, 佐田 尚宏
    日本臨床外科学会雑誌  2016/10  日本臨床外科学会
  • シナリオベースの低侵襲手術training systemの開発と活用 technical skillとnon technical skillの習得
    遠藤 和洋, 太白 健一, 笠原 直哉, 三木 厚, 小泉 大, 笹沼 英紀, 佐久間 康成, 堀江 久永, 細谷 好則, 北山 丈二, 佐田 尚宏
    日本臨床外科学会雑誌  2016/10  日本臨床外科学会
  • 膵体尾部切除における膵断端処理の工夫 膵体尾部切除における水平マットレス法による膵断端処理と術後膵液瘻の検討
    木村 有希, 小泉 大, 笠原 尚哉, 三木 厚, 遠藤 和洋, 笹沼 英紀, 佐久間 康成, 堀江 久永, 細谷 好則, 北山 丈二, 佐田 尚宏
    日本臨床外科学会雑誌  2016/10  日本臨床外科学会
  • クローン病腸管狭窄に対する内科外科連携に基づく治療戦略  [Not invited]
    伊藤 誉, 堀江 久永, 直井 大志, 田原 真紀子, 巷野 佳彦, 森本 光昭, 鯉沼 広治, 北山 丈二, 佐田 尚宏, 矢野 智則, 砂田 圭二郎, 山本 博徳
    日本大腸肛門病学会雑誌  2016/10  (一社)日本大腸肛門病学会
  • 齋藤晶, 森嶋計, 笠原尚哉, 三木厚, 笹沼英紀, 佐久間康成, 佐田尚宏, 安田是和
    日本臨床外科学会雑誌  2016/09  日本臨床外科学会
  • 安部望, 細谷好則, 金丸理人, 松本志郎, 春田英律, 倉科憲太郎, 佐田尚宏, 安田是和, 今田浩生, 福嶋敬宜
    日本臨床外科学会雑誌  2016/09  日本臨床外科学会
  • 胃癌・大腸癌切除例の術前CT検査で指摘された膵嚢胞性病変の検討  [Not invited]
    小泉 大, 木村 有希, 田口 昌延, 三木 広, 遠藤 和洋, 笹沼 英紀, 佐久間 康成, 堀江 久永, 細谷 好則, 北山 丈二, 佐田 尚宏
    日本消化器病学会雑誌  2016/09  (一財)日本消化器病学会
  • KOIZUMI Masaru, SATA Naohiro, KUROGOCHI Akira, SASANUMA Hideki, ISAJI Shuji, ITOI Takao, KITANO Masayuki, HIROTA Morihisa, MATSUMOTO Ippei, YASUDA Ichiro, TAKEYAMA Yoshifumi
    すい臓  2016/07
  • MIKI Atsushi, SAKUMA Yasunaru, ENDO Kazuhiro, KOIZUMI Masaru, SASANUMA Hideki, HORIE Hisanaga, HOSOYA Yoshinori, KITAYAMA Joji, SATA Naohiro
    すい臓  2016/07
  • OTA Gaku, MIKI Atsushi, ENDO Kazuhiro, KOIZUMI Masaru, SASANUMA Hideki, SAKUMA Yasunaru, HORIE Hisanaga, HOSOYA Yoshinori, KITAYAMA Joji, SATA Naohiro
    すい臓  2016/07
  • MITO Kumiko, SAITO Michihiro, MORITA Kohei, MAETANI Iruru, SATA Naohiro, FUKUSHIMA Noriyoshi
    すい臓  2016/07
  • 扁平上皮癌を合併した直腸肛門部尖圭コンジローマの1例
    伊藤 誉, 堀江 久永, 高橋 大二郎, 清水 徹一郎, 森本 光昭, 鯉沼 広治, 佐久間 康成, 細谷 好則, 北山 丈二, 佐田 尚宏
    日本消化器外科学会総会  2016/07  (一社)日本消化器外科学会
  • 当院における胃管癌の治療経験
    齋藤 心, 倉科 憲太郎, 宇井 崇, 松本 志郎, 金丸 理人, 春田 英律, 細谷 好則, 北山 丈二, 三浦 義正, 佐田 尚宏
    日本食道学会学術集会プログラム・抄録集  2016/07  (NPO)日本食道学会
  • 進行大腸癌に対するイメージガイド腹腔鏡手術
    堀江 久永, 伊藤 誉, 佐々木 崇洋, 森本 光昭, 鯉沼 広治, 佐久間 康成, 細谷 好則, Lefor Alan, 北山 丈二, 佐田 尚宏
    日本消化器外科学会総会  2016/07  (一社)日本消化器外科学会
  • 食道胃接合部癌に認めた内分泌神経細胞癌と中分化型腺癌の1例
    金丸 理人, 斎藤 心, 宇井 崇, 倉科 憲太郎, 細谷 好則, 北山 丈二, 佐田 尚宏, 天野 雄介, 仁木 利郎
    日本食道学会学術集会プログラム・抄録集  2016/07  (NPO)日本食道学会
  • 外科における基礎的研究 セレンディピティーを求めて 短腸症モデルラットを用いたポリアミン摂取による治療効果の検討と小腸再生促進メカニズムの解明
    笠原 尚哉, 寺谷 工, 横田 真一郎, 三木 厚, 浦橋 泰然, 藤本 康弘, 佐久間 康成, 佐田 尚宏
    日本消化器外科学会総会  2016/07  (一社)日本消化器外科学会
  • 右側結腸手術に対するERASプロトコル導入の効果
    直井 大志, 堀江 久永, 田原 真紀子, 巷野 佳彦, 森本 光昭, 鯉沼 広治, 佐久間 康成, 細谷 好則, 北山 丈二, 佐田 尚宏
    日本消化器外科学会総会  2016/07  (一社)日本消化器外科学会
  • 直腸癌前方切除後患者におけるERASプロトコール導入に向けての検討
    巷野 佳彦, 堀江 久永, 田原 真紀子, 森本 光昭, 鯉沼 広治, 佐久間 康成, 細谷 好則, Lefor Alan, 北山 丈二, 佐田 尚宏
    日本消化器外科学会総会  2016/07  (一社)日本消化器外科学会
  • 腹部予定手術後肺合併症の予測における術前肺機能検査の有用性の検討
    横田 真一郎, 富樫 一智, アラン・レフォー, 小泉 大, 中村 好一, 堀江 久永, 細谷 好則, 北山 丈二, 佐田 尚宏, 安田 是和
    日本消化器外科学会総会  2016/07  (一社)日本消化器外科学会
  • 腹腔鏡補助下低位前方切除術における縫合不全ゼロへの取り組みと、予防的回腸瘻造設基準の評価
    鯉沼 広治, 堀江 久永, 森本 光昭, 巷野 佳彦, 田原 真紀子, 丸山 博行, 佐久間 康成, 細谷 好則, 北山 丈二, 佐田 尚宏
    日本消化器外科学会総会  2016/07  (一社)日本消化器外科学会
  • 当院における直腸癌に対する術前放射線療法の功罪
    森本 光昭, 堀江 久永, 鯉沼 広治, 巷野 佳彦, 藤井 博文, 佐久間 康成, 細谷 好則, Lefor Alan, 北山 丈二, 佐田 尚宏
    日本消化器外科学会総会  2016/07  (一社)日本消化器外科学会
  • Treatment of Local Complication of Severe Acute Pancreatitis Nationwide survey of the treatment of local complications of severe acute pancreatitis in Japan(和訳中)  [Not invited]
    Koizumi Masaru, Sata Naohiro, Kurogochi Akira, Sasanuma Hideki, Isaji Shuji, Itoi Takao, Kitano Masayuki, Hirota Morihisa, Matsumoto Ippei, Yasuda Ichiro, Takeyama Yoshifumi
    膵臓  2016/07  日本膵臓学会
  • 胃切除後の食道再建術式 食道切除後の血管吻合付加を伴う胸骨前Roux-en Y型空腸再建の検討  [Not invited]
    細谷 好則, 斉藤 心, 倉科 憲太郎, 去川 俊二, 中村 美鈴, 佐久間 康成, 堀江 久永, アラン・レフォー, 北山 丈二, 佐田 尚宏
    日本消化器外科学会総会  2016/07  (一社)日本消化器外科学会
  • 若手外科医育成のための工夫 自治医科大学での外科医教育 解剖学教室、先端医療技術開発センター、シミュレーションセンターとの連携  [Not invited]
    清水 敦, 菱川 俊司, 野田 泰子, 笹沼 英紀, 佐久間 康成, 堀江 久永, 細谷 好則, アラン・レフォー, 北山 丈二, 佐田 尚宏
    日本消化器外科学会総会  2016/07  (一社)日本消化器外科学会
  • Blumgart-dumpling法による膵空腸吻合の工夫  [Not invited]
    小泉 大, 三木 厚, 遠藤 和洋, 笹沼 英紀, 佐久間 康成, 堀江 久永, 細谷 好則, 北山 丈二, Lefor Alan, 佐田 尚宏
    日本消化器外科学会総会  2016/07  (一社)日本消化器外科学会
  • 湯澤真梨子, 三木厚, 利府和馬, 笹沼英紀, 佐久間康成, 堀江久永, 細谷好則, 佐田尚宏
    栃木県医学会々誌  2016/06  栃木県医学会
  • 大腸癌肝転移に対する化学療法・拡大右肝切除後に脾動脈瘤のコイル塞栓術を施行し脾摘を回避しえた1例
    清水 敦, 眞田 幸弘, 佐久間 康成, 堀江 久永, 細谷 好則, 北山 丈二, 佐田 尚宏
    日本肝胆膵外科学会・学術集会プログラム・抄録集  2016/06  (一社)日本肝胆膵外科学会
  • 転移性肝癌との鑑別に苦慮した肝柵状肉芽腫の一例
    森本 光昭, 佐久間 康成, 笹沼 秀紀, 小泉 大, 遠藤 和洋, 三木 厚, 北山 丈二, アラン・レフォー, 佐田 尚宏
    日本肝胆膵外科学会・学術集会プログラム・抄録集  2016/06  (一社)日本肝胆膵外科学会
  • 芝 聡美, 藤田 崇史, 櫻木 雅子, 上徳 ひろみ, 宮崎 千絵子, 西田 紗季, 田中 裕美子, 相良 由佳, 水沼 洋文, 佐田 尚宏
    日本乳癌学会総会プログラム抄録集  2016/06  (一社)日本乳癌学会
  • 西田 紗季, 藤田 崇史, 相良 由佳, 田中 裕美子, 芝 聡美, 宮崎 千絵子, 上徳 ひろみ, 櫻木 雅子, 佐田 尚宏
    日本乳癌学会総会プログラム抄録集  2016/06  (一社)日本乳癌学会
  • 田中 裕美子, 藤田 崇史, 小川 れをな, 相良 由佳, 西田 紗季, 芝 聡美, 宮崎 千絵子, 上徳 ひろみ, 櫻木 雅子, 佐田 尚宏
    日本乳癌学会総会プログラム抄録集  2016/06  (一社)日本乳癌学会
  • 宮崎 千絵子, 相良 由佳, 田中 裕美子, 芝 聡美, 上徳 ひろみ, 櫻木 雅子, 水沼 洋文, 佐田 尚宏, 藤田 崇史
    日本乳癌学会総会プログラム抄録集  2016/06  (一社)日本乳癌学会
  • 櫻木 雅子, 平 幸輝, 相良 由佳, 田中 裕美子, 芝 聡美, 宮崎 千絵子, 上徳 ひろみ, 水沼 洋文, 藤田 崇史, 佐田 尚宏
    日本乳癌学会総会プログラム抄録集  2016/06  (一社)日本乳癌学会
  • 上徳 ひろみ, 相良 由佳, 田中 裕美子, 芝 聡美, 宮崎 千絵子, 櫻木 雅子, 水沼 洋文, 藤田 崇史, 佐田 尚宏
    日本乳癌学会総会プログラム抄録集  2016/06  (一社)日本乳癌学会
  • 小泉大, 田口昌延, 三木厚, 遠藤和洋, 笹沼英紀, 佐久間康成, 堀江久永, 細谷好則, 北山丈二, LEFOR Alan Kawarai, 佐田尚宏
    日本肝胆膵外科学会学術集会プログラム・抄録集(CD-ROM)  2016/06  (一社)日本肝胆膵外科学会
  • 胃壁筋層内へ穿破し出血を生じた膵粘液性嚢胞腫瘍の1例  [Not invited]
    太田 学, 三木 厚, 遠藤 和洋, 小泉 大, 笹沼 英紀, 佐久間 康成, 堀江 久永, 細谷 好則, 北山 丈二, 佐田 尚宏
    日本肝胆膵外科学会・学術集会プログラム・抄録集  2016/06  (一社)日本肝胆膵外科学会
  • 十二指腸乳頭部神経内分泌癌の一例  [Not invited]
    加賀谷 丈紘, 三木 厚, 遠藤 和洋, 小泉 大, 笹沼 英紀, 佐久間 康成, 堀江 久永, 細谷 好則, 北山 丈二, 佐田 尚宏
    日本肝胆膵外科学会・学術集会プログラム・抄録集  2016/06  (一社)日本肝胆膵外科学会
  • 非黄疸胆道閉鎖症における肝移植適応  [Not invited]
    眞田 幸弘, 浦橋 泰然, 井原 欣幸, 山田 直也, 岡田 憲樹, 平田 雄大, 片野 匠, 三木 厚, 笹沼 英紀, 佐久間 康成, 佐田 尚宏, 水田 耕一
    日本肝胆膵外科学会・学術集会プログラム・抄録集  2016/06  (一社)日本肝胆膵外科学会
  • 胃壁筋層内へ穿破し出血を生じた膵粘液性嚢胞腫瘍の1例  [Not invited]
    太田 学, 三木 厚, 遠藤 和洋, 小泉 大, 笹沼 英紀, 佐久間 康成, 堀江 久永, 細谷 好則, 北山 丈二, 佐田 尚宏
    日本肝胆膵外科学会・学術集会プログラム・抄録集  2016/06  (一社)日本肝胆膵外科学会
  • 十二指腸乳頭部神経内分泌癌の一例  [Not invited]
    加賀谷 丈紘, 三木 厚, 遠藤 和洋, 小泉 大, 笹沼 英紀, 佐久間 康成, 堀江 久永, 細谷 好則, 北山 丈二, 佐田 尚宏
    日本肝胆膵外科学会・学術集会プログラム・抄録集  2016/06  (一社)日本肝胆膵外科学会
  • 膵硬化度・主膵管拡張に注目した膵空腸吻合法の選択と術後膵液瘻の検討  [Not invited]
    小泉 大, 田口 昌延, 三木 厚, 遠藤 和洋, 笹沼 英紀, 佐久間 康成, 堀江 久永, 細谷 好則, 北山 丈二, アラン・レフォー, 佐田 尚宏
    日本肝胆膵外科学会・学術集会プログラム・抄録集  2016/06  (一社)日本肝胆膵外科学会
  • 太白 健一, 堀江 久永, 田原 真紀子, 巷野 佳彦, 森本 光昭, 小泉 大, 鯉沼 広治, 佐久間 康成, 細谷 好則, 北山 丈二, 佐田 尚宏
    小切開・鏡視外科学会雑誌  2016/05  (NPO)小切開・鏡視外科学会
  • 膠原病を合併した小腸穿孔症例の検討
    齋藤 心, 倉科 憲太郎, 松本 志郎, 堀江 久永, 佐久間 康成, 簑田 清次, 岩本 雅弘, 松原 大佑, 福島 敬宣, 細谷 好則, 佐田 尚宏
    日本外科学会定期学術集会抄録集  2016/04  (一社)日本外科学会
  • シニアレジデントに対する腹腔鏡下結腸切除トレーニングシステム
    堀江 久永, 鯉沼 広治, 津久井 秀則, 熊谷 祐子, 佐田友 藍, 清水 徹一郎, 直井 大志, 田原 真紀子, 巷野 佳彦, 森 和亮, 伊藤 誉, 井上 賢之, 森本 光昭, 佐久間 康成, 細谷 好則, 佐田 尚宏
    日本外科学会定期学術集会抄録集  2016/04  (一社)日本外科学会
  • 大腸癌治療におけるERAS導入とその実践 直腸癌手術症例における早期経口摂取の検討
    巷野 佳彦, 堀江 久永, 津久井 秀則, 熊谷 祐子, 佐田友 藍, 清水 徹一郎, 直井 大志, 田原 真紀子, 伊藤 誉, 森 和亮, 井上 賢之, 森本 光昭, 鯉沼 広治, 細谷 好則, 佐田 尚宏
    日本外科学会定期学術集会抄録集  2016/04  (一社)日本外科学会
  • 術前(化学)放射線療法を施行した下部進行直腸癌における術後再発リスク因子の検討
    田原 真紀子, 堀江 久永, 津久井 秀則, 熊谷 裕子, 佐田友 藍, 清水 徹一郎, 直井 大志, 井上 賢之, 巷野 佳彦, 森 和亮, 森本 光昭, 伊藤 誉, 鯉沼 広治, 佐久間 康成, 細谷 好則, 藤井 博文, 仲澤 聖則, 佐田 尚宏
    日本外科学会定期学術集会抄録集  2016/04  (一社)日本外科学会
  • Checklist方式による、腹腔鏡補助下低位前方切除後縫合不全ゼロへの試み
    鯉沼 広治, 堀江 久永, 森本 光昭, 巷野 佳彦, 田原 真紀子, 熊谷 祐子, 津久井 秀則, 直井 大志, 佐田友 藍, 伊藤 誉, 森 和亮, 井上 賢之, 清水 徹一郎, 佐田 尚宏
    日本外科学会定期学術集会抄録集  2016/04  (一社)日本外科学会
  • 大腸癌肝転移切除後に補助化学療法(mFOLFOX6)を施行した症例の予後
    津久井 秀則, 森本 光昭, 堀江 久永, 熊谷 祐子, 田原 真紀子, 佐田友 藍, 清水 徹一郎, 直井 大志, 井上 賢之, 巷野 佳彦, 森 和亮, 伊藤 誉, 鯉沼 広治, 佐久間 康成, 細谷 好則, 藤井 博文, 佐田 尚宏
    日本外科学会定期学術集会抄録集  2016/04  (一社)日本外科学会
  • 抗血栓薬のヘパリン置換による周術期管理の検討
    太田 学, 小泉 大, 森本 光昭, 佐久間 康成, 堀江 久永, 細谷 好則, 穂積 康夫, 佐田 尚宏
    日本外科学会定期学術集会抄録集  2016/04  (一社)日本外科学会
  • 新規分子標的薬を用いた、原発性十二指腸癌に対する新規治療開発
    芝 聡美, 三木 厚, 大澤 英之, 寺谷 工, 佐久間 康成, 堀江 久永, 細谷 好則, 佐田 尚宏
    日本外科学会定期学術集会抄録集  2016/04  (一社)日本外科学会
  • 肝Rouviere溝の閉鎖症例には胆管アノマリーが高率に存在する 医原性胆道損傷回避にむけてclosed Rouviere's sulcus signの提唱
    清水 敦, 野田 泰子, 佐田 尚宏
    日本外科学会定期学術集会抄録集  2016/04  (一社)日本外科学会
  • 乳癌術後経過観察中に発見し、診断に難渋した異時性重複癌の1例
    湯澤 真梨子, 三木 厚, 利府 数馬, 遠藤 和洋, 小泉 大, 笹沼 英紀, 佐久間 康成, 堀江 久永, 細谷 好則, 佐田 尚宏
    日本外科学会定期学術集会抄録集  2016/04  (一社)日本外科学会
  • 後腹膜脂肪肉腫の臨床病理学的検討
    丸山 博行, 佐久間 康成, 堀江 久永, 細谷 好則, 佐田 尚宏
    日本外科学会定期学術集会抄録集  2016/04  (一社)日本外科学会
  • 小泉大, 田口昌延, 三木厚, 遠藤和洋, 笹沼英紀, 佐久間康成, 堀江久永, 細谷好則, 佐田尚宏
    日本外科学会定期学術集会(Web)  2016/04  (一社)日本外科学会
  • 倉科憲太郎, 三木厚, 松本健司, 村越美穂, 佐藤敏子, 小暮亜弥子, 齋藤心, 鯉沼広治, 笹沼英紀, 小泉大, 佐久間康成, 堀江久永, 細谷好則, 佐田尚宏
    日本外科学会定期学術集会(Web)  2016/04  (一社)日本外科学会
  • 湯澤真梨子, 三木厚, 利府数馬, 遠藤和洋, 小泉大, 笹沼英紀, 佐久間康成, 堀江久永, 細谷好則, 佐田尚宏
    日本外科学会定期学術集会(Web)  2016/04  (一社)日本外科学会
  • 幽門狭窄進行胃癌に術前処置としてパンクレリパーゼを投与した3例の検討
    宇井 崇, 澁澤 公行, 佐久間 和也, 高橋 修平, 細谷 好則, 佐田 尚宏
    日本胃癌学会総会記事  2016/03  (一社)日本胃癌学会
  • 齋藤 心, 倉科 憲太郎, 松本 志郎, 宇井 崇, あらん・れふぉ, 田中 亨, 藤井 博文, 細谷 好則, 佐田 尚宏
    日本胃癌学会総会記事  2016/03  (一社)日本胃癌学会
  • 倉科 憲太郎, 細谷 好則, 齋藤 心, 松本 志郎, 小暮 亜弥子, 佐藤 敏子, 村越 美穂, 荒川 由起子, 岡田 憲樹, 春田 英律, 宇井 崇, 三木 厚, 堀江 久永, 佐久間 康成, 佐田 尚宏
    日本胃癌学会総会記事  2016/03  (一社)日本胃癌学会
  • 松本 志郎, 細谷 好則, 倉科 憲太郎, 齋藤 心, 井野 祐治, 三浦 義正, 山本 博徳, 佐久間 康成, 堀江 久永, 佐田 尚宏
    日本胃癌学会総会記事  2016/03  (一社)日本胃癌学会
  • 胃癌手術における周術期栄養剤投与による体重減少への影響 ランダム化比較試験
    倉科 憲太郎, 細谷 好則, 小暮 亜弥子, 村越 美穂, 佐藤 敏子, 荒川 由起子, 齋藤 心, 松本 志郎, 春田 英律, 宇井 崇, 三木 厚, 佐久間 康成, 堀江 久永, 佐田 尚宏
    日本静脈経腸栄養学会雑誌  2016/01  (株)ジェフコーポレーション
  • 当院における腹腔鏡下Sleeve状胃切除の成績
    細谷 好則, 春田 英律, 斉藤 心, 倉科 憲太郎, 宇井 崇, 松本 志郎, 安部 望, 佐久間 康成, 堀江 久永, アラン・レフォー, 佐田 尚宏
    日本内視鏡外科学会雑誌  2015/12  (一社)日本内視鏡外科学会
  • 成人発症のmalrotationに対し、腹腔鏡下手術を施行した1例
    青木 裕一, 伊藤 誉, 田原 真紀子, 巷野 佳彦, 森本 光昭, 鯉沼 広治, 宮倉 安幸, 堀江 久永, 佐田 尚宏
    日本内視鏡外科学会雑誌  2015/12  (一社)日本内視鏡外科学会
  • 腹腔鏡下右側結腸手術に対するERASプロトコル導入の短期成績
    直井 大志, 堀江 久永, 佐田友 藍, 清水 徹一郎, 田原 真紀子, 巷野 佳彦, 伊藤 誉, 森 和亮, 井上 賢之, 森本 光昭, 鯉沼 広治, 佐久間 康成, 細谷 好則, 佐田 尚宏
    日本内視鏡外科学会雑誌  2015/12  (一社)日本内視鏡外科学会
  • 腹腔鏡下腹会陰式直腸切断術における後腹膜経路でのストーマ造設の工夫
    伊藤 誉, 堀江 久永, 田原 真紀子, 巷野 佳彦, 森本 光昭, 鯉沼 広治, 宮倉 安幸, 佐田 尚宏
    日本内視鏡外科学会雑誌  2015/12  (一社)日本内視鏡外科学会
  • 当院における腹腔鏡下直腸切断術の大網有茎フラップ作成と結腸ストマ造設術
    巷野 佳彦, 堀江 久永, 佐田友 藍, 清水 徹一郎, 直井 大志, 田原 真紀子, 伊藤 誉, 森 和亮, 井上 賢之, 森本 光昭, 鯉沼 広治, 佐久間 康成, 細谷 好則, 佐田 尚宏
    日本内視鏡外科学会雑誌  2015/12  (一社)日本内視鏡外科学会
  • 回腸重複腸管からの出血に対して単孔式腹腔鏡手術を行った1例
    熊谷 祐子, 伊藤 誉, 田原 真紀子, 巷野 佳彦, 森本 光昭, 鯉沼 広治, 宮倉 安幸, 堀江 久永, 佐田 尚宏
    日本内視鏡外科学会雑誌  2015/12  (一社)日本内視鏡外科学会
  • 肥満症例における腹腔鏡下直腸切除術の検討
    田原 真紀子, 堀江 久永, 森本 光昭, 佐田友 藍, 清水 徹一郎, 直井 大志, 井上 賢之, 巷野 佳彦, 森 和亮, 伊藤 誉, 鯉沼 広治, 佐久間 康成, 細谷 好則, 佐田 尚宏
    日本内視鏡外科学会雑誌  2015/12  (一社)日本内視鏡外科学会
  • 横行結腸癌に対する手技の定型化は可能か? 腹腔鏡下横行結腸癌手術の普及には、個別化も重要である
    鯉沼 広治, 堀江 久永, 森本 光昭, 巷野 佳彦, 田原 真紀子, 清水 徹一郎, 伊藤 誉, 佐田友 藍, 井上 賢之, 直井 大志, 森 和亮, 佐田 尚宏
    日本内視鏡外科学会雑誌  2015/12  (一社)日本内視鏡外科学会
  • 誰も教えてくれない手術機器のうまい使い方 LCS 腹腔鏡下直腸手術におけるLCSによるsurgical smoke、ミストの対策について
    森本 光昭, 堀江 久永, 鯉沼 広治, 井上 賢之, 伊藤 誉, 清水 徹一郎, 巷野 佳彦, 田原 真紀子, 直井 大志, 佐田友 藍, 佐久間 康成, 細谷 好則, Lefor Alan, 佐田 尚宏
    日本内視鏡外科学会雑誌  2015/12  (一社)日本内視鏡外科学会
  • 内視鏡外科のこれからの教育 工夫を持ち寄って最善を探る 開腹手術経験の少ない若手医師に対する腹腔鏡下結腸切除トレーニングシステム
    堀江 久永, 鯉沼 広治, 森本 光昭, 田原 真紀子, 佐田友 藍, 清水 徹一郎, 直井 大志, 井上 賢之, 巷野 佳彦, 森 和亮, 伊藤 誉, 佐久間 康成, 細谷 好則, 佐田 尚宏
    日本内視鏡外科学会雑誌  2015/12  (一社)日本内視鏡外科学会
  • 腹腔鏡下肝切除にRFAを併用して治療した肝細胞癌2例  [Not invited]
    森嶋 計, 笠原 尚哉, 三木 厚, 遠藤 和洋, 小泉 大, 笹沼 英紀, 佐久間 康成, 堀江 久永, 細谷 好則, 佐田 尚宏
    日本内視鏡外科学会雑誌  2015/12  (一社)日本内視鏡外科学会
  • 腹腔鏡下膵体尾部切除術の完全腹腔鏡下手術例と小切開併用手術例の比較検討  [Not invited]
    吉田 淳, 佐久間 康成, 三木 厚, 遠藤 和洋, 小泉 大, 笹沼 英紀, 堀江 久永, 細谷 好則, 佐田 尚宏
    日本内視鏡外科学会雑誌  2015/12  (一社)日本内視鏡外科学会
  • 専門医を目指すための気腹状態dry boxと臓器ユニットの開発 シナリオベースsimulation trainingの実現  [Not invited]
    遠藤 和洋, 太白 健一, 笹沼 英紀, 佐久間 康成, 堀江 久永, 細谷 好則, 佐田 尚宏
    日本内視鏡外科学会雑誌  2015/12  (一社)日本内視鏡外科学会
  • 実体臓器モデルの内視鏡手術への活用 手術トレーニングに特化した軟部組織実体臓器モデルの開発と製品化  [Not invited]
    遠藤 和洋, 太白 健一, 笹沼 英紀, 佐久間 康成, 堀江 久永, 細谷 好則, 佐田 尚宏
    日本内視鏡外科学会雑誌  2015/12  (一社)日本内視鏡外科学会
  • 利府数馬, 三木厚, 遠藤和洋, 小泉大, 笹沼英紀, 佐久間康成, 堀江久永, 細谷好則, 佐田尚宏
    日本臨床外科学会雑誌  2015/10  日本臨床外科学会
  • 倉科憲太郎, 三木厚, 松本健司, 鯉沼広治, 齋藤心, 小泉大, 笹沼英紀, 佐久間康成, 堀江久永, 細谷好則, 佐田尚宏
    日本臨床外科学会雑誌  2015/10  日本臨床外科学会
  • 遠藤和洋, 太白健一, 三木厚, 小泉大, 笹沼英紀, 佐久間康成, 堀江久永, 細谷好則, 佐田尚宏
    日本臨床外科学会雑誌  2015/10  日本臨床外科学会
  • 小泉大, 田口昌延, 三木厚, 遠藤和洋, 笹沼英紀, 佐久間康成, 堀江久永, 細谷好則, 佐田尚宏
    日本臨床外科学会雑誌  2015/10  日本臨床外科学会
  • 田口昌延, 笠原尚哉, 森嶋計, 石黒保直, 兼田裕司, 三木厚, 遠藤和洋, 小泉大, 笹沼英紀, 俵藤正信, 佐久間康成, 安田是和, 佐田尚宏
    日本臨床外科学会雑誌  2015/10  日本臨床外科学会
  • 腹部大動脈瘤術後に十二指腸と孔形成した1例  [Not invited]
    熊谷 祐子, 三木 厚, 遠藤 和洋, 小泉 大, 笹沼 英紀, 佐久間 康成, 佐田 尚宏
    Japanese Journal of Acute Care Surgery  2015/10  日本Acute Care Surgery学会
  • 門脈二次分枝の腫瘍栓を伴う胃癌の1手術例
    熊谷 祐子, 田口 昌延, 松本 志郎, 瑞木 亨, 倉科 憲太郎, 齋藤 心, 細谷 好則, 安田 是和, 佐田 尚宏
    日本臨床外科学会雑誌  2015/10  日本臨床外科学会
  • 腹腔鏡下鼡径ヘルニア手術(TEP)症例の検討
    巷野 佳彦, 小泉 大, 大木 準, 瑞木 亨, 春田 英律, 佐田 尚宏
    日本臨床外科学会雑誌  2015/10  日本臨床外科学会
  • 縫合不全ゼロを目指した、腹腔鏡補助下低位前方切除術の試み
    鯉沼 広治, 堀江 久永, 森本 光昭, 巷野 佳彦, 田原 真紀子, 清水 徹一郎, 伊藤 誉, 井上 賢之, 直井 大志, 佐田 尚宏
    日本臨床外科学会雑誌  2015/10  日本臨床外科学会
  • 高齢大腸癌患者における腹腔鏡下大腸切除術の適応について
    田原 真紀子, 堀江 久永, 森本 光昭, 清水 徹一郎, 直井 大志, 井上 賢之, 巷野 佳彦, 伊藤 誉, 鯉沼 広治, 佐久間 康成, 細谷 好則, 佐田 尚宏
    日本臨床外科学会雑誌  2015/10  日本臨床外科学会
  • 内視鏡外科手技と器具の工夫(小腸、結腸、直腸) 腹腔鏡下大腸切除術におけるsurgical smoke対策について
    森本 光昭, 堀江 久永, 鯉沼 広治, 井上 賢之, 伊藤 誉, 清水 徹一郎, 巷野 佳彦, 田原 真紀子, 直井 大志, 宮倉 安幸, 佐久間 康成, 細谷 好則, Lefor Alan, 佐田 尚宏
    日本臨床外科学会雑誌  2015/10  日本臨床外科学会
  • 内視鏡外科手術の現状と将来(小腸、結腸、直腸) 腹腔鏡下大腸切除術の適応拡大に向けて 定型化から個別化へ
    堀江 久永, 伊藤 誉, 鯉沼 広治, 森本 光昭, 田原 真紀子, 清水 徹一郎, 直井 大志, 井上 賢之, 巷野 佳彦, 森 和亮, 佐久間 康成, 細谷 好則, 佐田 尚宏
    日本臨床外科学会雑誌  2015/10  日本臨床外科学会
  • 多発性内分泌腺腫症に起因する虫垂カルチノイド腫瘍の1例
    平瀬 雄規, 森本 光昭, 太田 学, 津久井 秀則, 田原 真紀子, 佐久間 康成, 堀江 久永, 細谷 好則, 佐田 尚宏
    日本臨床外科学会雑誌  2015/10  日本臨床外科学会
  • 123I-MIBGシンチグラフィで集積を認めなかった褐色細胞腫の3例の臨床的検討
    利府 数馬, 三木 厚, 遠藤 和洋, 小泉 大, 笹沼 英紀, 佐久間 康成, 堀江 久永, 細谷 好則, 佐田 尚宏
    日本臨床外科学会雑誌  2015/10  日本臨床外科学会
  • 手術シナリオをベースとした、人体を忠実に再現した手術simulationシステムの開発
    遠藤 和洋, 太白 健一, 三木 厚, 小泉 大, 笹沼 英紀, 佐久間 康成, 堀江 久永, 細谷 好則, 佐田 尚宏
    日本臨床外科学会雑誌  2015/10  日本臨床外科学会
  • 胆管内に肝吸虫を認めた肝門部胆管癌の一症例  [Not invited]
    菅谷 涼, 佐久間 康成, 三木 厚, 笹沼 英紀, 堀江 久永, 細谷 好則, 佐田 尚宏
    日本臨床外科学会雑誌  2015/10  日本臨床外科学会
  • 後腹膜気管支原性嚢胞の1例  [Not invited]
    坂田 知久, 三木 厚, 利府 数馬, 遠藤 和洋, 小泉 大, 笹沼 英紀, 佐久間 康成, 堀江 久永, 細谷 好則, 佐田 尚宏
    日本臨床外科学会雑誌  2015/10  日本臨床外科学会
  • 3Dプリンターの医学への応用 消化器外科における3D printerの活用 現況と問題点、その解決案まで  [Not invited]
    遠藤 和洋, 三木 厚, 小泉 大, 笹沼 英紀, 佐久間 康成, 堀江 久永, 細谷 好則, 佐田 尚宏
    日本臨床外科学会雑誌  2015/10  日本臨床外科学会
  • 直腸肛門部悪性黒色腫の1例
    菅野 真之, 伊藤 誉, 田原 真紀子, 巷野 佳彦, 森本 光昭, 鯉沼 広治, 宮倉 安幸, 堀江 久永, 佐田 尚宏
    日本大腸肛門病学会雑誌  2015/09  (一社)日本大腸肛門病学会
  • 75歳以上の高齢大腸癌患者における腹腔鏡下大腸切除術の検討
    田原 真紀子, 堀江 久永, 森本 光昭, 佐田友 藍, 清水 徹一郎, 直井 大志, 井上 賢之, 巷野 佳彦, 伊藤 誉, 鯉沼 広治, 佐田 尚宏
    日本大腸肛門病学会雑誌  2015/09  (一社)日本大腸肛門病学会
  • 当科における下部進行直腸癌に対する治療戦略の変革について
    森本 光昭, 堀江 久永, 宮倉 安幸, 鯉沼 広治, 井上 賢之, 伊藤 誉, 巷野 佳彦, 清水 徹一郎, 田原 真紀子, 直井 大志, 佐田友 藍, 藤井 博文, 佐田 尚宏
    日本大腸肛門病学会雑誌  2015/09  (一社)日本大腸肛門病学会
  • クローン病腸管狭窄に対する内科外科連携に基づく治療戦略
    伊藤 誉, 堀江 久永, 田原 真紀子, 巷野 佳彦, 森本 光昭, 鯉沼 広治, 宮倉 安幸, 佐田 尚宏, 山本 博徳
    日本大腸肛門病学会雑誌  2015/09  (一社)日本大腸肛門病学会
  • Bevacizumab併用化学療法中にフルニエ壊疽を発症した2例
    青木 裕一, 伊藤 誉, 田原 真紀子, 巷野 佳彦, 森本 光昭, 鯉沼 広治, 宮倉 安幸, 堀江 久永, 藤井 博文, 佐田 尚宏
    日本癌治療学会誌  2015/09  (一社)日本癌治療学会
  • 乳癌に対するBevacizumab併用化学療法中に結腸多発潰瘍による穿孔性腹膜炎を来した1例
    高木 徹, 伊藤 誉, 田原 真紀子, 巷野 佳彦, 森本 光昭, 櫻木 雅子, 鯉沼 広治, 藤田 崇史, 宮倉 安幸, 堀江 久永, 穂積 康夫, 佐田 尚宏
    日本癌治療学会誌  2015/09  (一社)日本癌治療学会
  • 直腸神経鞘腫の一例
    熊谷 祐子, 伊藤 誉, 田原 真紀子, 巷野 佳彦, 森本 光昭, 鯉沼 広治, 堀江 久永, 佐田 尚宏
    日本大腸肛門病学会雑誌  2015/09  (一社)日本大腸肛門病学会
  • 胃癌・大腸癌手術症例の術前に指摘された膵嚢胞性病変の検討  [Not invited]
    小泉 大, 佐田 尚宏, 田口 昌延, 森嶋 計, 三木 厚, 遠藤 和洋, 笹沼 英紀, 佐久間 康成, 堀江 久永, 細谷 好則, 安田 是和
    日本消化器病学会雑誌  2015/09  (一財)日本消化器病学会
  • 「複雑な合流」を呈する膵・胆管合流異常症例から推測される膵・胆管合流異常の発生機序  [Not invited]
    眞田 幸弘, 森嶋 計, 笠原 尚哉, 三木 厚, 遠藤 和洋, 小泉 大, 笹沼 英紀, 佐久間 康成, 佐田 尚宏, 安田 是和
    日本膵・胆管合流異常研究会プロシーディングス  2015/09  日本膵・胆管合流異常研究会
  • 早期膵がん・リスク疾患検出のための血漿バイオマーカーの開発 Apolipoprtien All isoformsによる早期膵がん・リスク疾患の検出  [Not invited]
    本田 一文, 小林 道元, 奥坂 拓志, 中森 正二, 島原 政司, 植野 高章, 土田 明彦, 佐田 尚宏, 井岡 達也, 安波 洋一, 小菅 智男, 鄭 基晩, 吉田 優, 東 健, 山田 哲司
    日本分子腫瘍マーカー研究会プログラム・講演抄録  2015/09  日本分子腫瘍マーカー研究会
  • 内視鏡的粘膜切開生検が診断に有用であった直腸癌術後吻合部に発生したSMT様線維性腫瘤の1例  [Not invited]
    森本 光昭, 鯉沼 広治, 堀江 久永, 井上 賢之, 伊藤 誉, 巷野 佳彦, 清水 徹一郎, 佐田 尚宏, 山本 博徳, 砂田 圭二郎, 林 芳和, 安田 是和
    Gastroenterological Endoscopy  2015/09  (一社)日本消化器内視鏡学会
  • MORISHIMA KAZUE, KASAHARA NAOYA, ISHIGURO YASUNAO, MIKI ATSUSHI, ENDO KAZUHIRO, KOIZUMI MASARU, SASANUMA HIDEKI, SAKUMA YASUNARI, YASUDA YOSHIKAZU, SATA NAOHIRO
    胆道  2015/08  日本胆道学会
  • 三木 厚, 佐久間 康成, 遠藤 和洋, 小泉 大, 笹沼 秀紀, 佐田 尚宏
    胆道  2015/08  日本胆道学会
  • 自治医科大学におけるマルチメディア形式総合判定試験の6年の解析  [Not invited]
    松山 泰, 三重野 牧子, 武藤 弘行, 江口 和男, 石川 鎮清, 佐田 尚宏, 岡崎 仁昭
    医学教育  2015/07  (一社)日本医学教育学会
  • Stage II/III食道癌の治療 進行胸部食道癌における術前化学療法(DCF療法)の経験 CF療法との比較
    宇井 崇, 藤井 博文, 細谷 好則, 齋藤 心, 倉科 憲太郎, 春田 英律, 松本 志郎, 安部 望, 佐田 尚宏, 安田 是和
    日本消化器外科学会総会  2015/07  (一社)日本消化器外科学会
  • 横隔膜上食道憩室内癌の1切除例
    松本 志郎, 細谷 好則, 安部 望, 春田 英律, 宇井 崇, 倉科 憲太郎, 齋藤 心, 佐田 尚宏, 安田 是和, 福島 敬宜
    日本食道学会学術集会プログラム・抄録集  2015/07  (NPO)日本食道学会
  • 下部進行直腸癌に対する術前化学放射線療法によるリンパ節縮小率、予後及び側方リンパ節転移の関連について
    森本 光昭, 堀江 久永, 宮倉 安幸, 井上 賢之, 伊藤 誉, 田中 宏幸, 直井 大志, 佐田 尚宏, アラン・レフォー, 安田 是和
    日本消化器外科学会総会  2015/07  (一社)日本消化器外科学会
  • 非密生型家族性大腸腺腫症に対する腹腔鏡下結腸全摘回腸直腸吻合の適応について
    堀江 久永, 鯉沼 広治, 森本 光昭, 伊藤 誉, 佐田友 藍, 井上 賢之, 巷野 佳彦, 清水 徹一郎, 佐田 尚宏, 安田 是和
    日本消化器外科学会総会  2015/07  (一社)日本消化器外科学会
  • 当科の小腸DLBCL(Diffuse large B-cell lymphoma)に対する手術例の検討
    高橋 和也, 伊藤 誉, 森本 光昭, 鯉沼 広治, 宮倉 安幸, 堀江 久永, 佐田 尚宏, 安田 是和
    日本消化器外科学会総会  2015/07  (一社)日本消化器外科学会
  • Crohn病の経過中に生じ腰椎麻酔下生検で診断し得た肛門管癌の1例
    中尾 祐樹, 森本 光昭, 井上 賢之, 直井 大志, 佐田友 藍, 伊藤 誉, 鯉沼 広治, 堀江 久永, 佐田 尚宏, 安田 是和
    日本消化器外科学会総会  2015/07  (一社)日本消化器外科学会
  • 3DCT、超細径内視鏡を用いた左側大腸狭窄に対する口側腸管病変の検索
    伊藤 誉, 高橋 和也, 佐々木 崇洋, 森本 光昭, 鯉沼 広治, 宮倉 安幸, 堀江 久永, 佐田 尚宏, 安田 是和
    日本消化器外科学会総会  2015/07  (一社)日本消化器外科学会
  • 短腸症モデルラットを用いたポリアミン摂取による治療効果の検討と小腸再生促進メカニズムの解明
    笠原 尚哉, 寺谷 工, 三木 厚, 佐久間 康成, 藤本 康弘, 上本 伸二, 佐田 尚宏, 安田 是和
    日本消化器外科学会総会  2015/07  (一社)日本消化器外科学会
  • 消化器外科における凝固線溶異常 静脈血栓塞栓症(VTE)に関する術前スクリーニング(Coagulation Abnormalities in Gastroenterological Surgery Pre-operative screening for venous thromboembolism(VTE))
    清水 徹一郎, 堀江 久永, 窓岩 清治, 大森 司, 三室 淳, 西村 智, 坂田 洋一, 細谷 好則, 佐田 尚宏, 安田 是和
    日本消化器外科学会総会  2015/07  (一社)日本消化器外科学会
  • 早期十二指腸乳頭部癌治療戦略における縮小手術の位置づけ  [Not invited]
    小泉 大, 佐田 尚宏, 田口 昌延, 笠原 尚哉, 森嶋 計, 三木 厚, 笹沼 英紀, 佐久間 康成, 安田 是和
    日本消化器外科学会総会  2015/07  (一社)日本消化器外科学会
  • 膵管内乳頭粘液性腫瘍のテロメア長測定による悪性度診断法の新規開発  [Not invited]
    三木 厚, 佐久間 康成, 笹沼 英紀, 森嶋 計, 笠原 尚哉, 大澤 英之, 眞田 幸広, 田久保 海誉, 佐田 尚宏, 安田 是和
    日本消化器外科学会総会  2015/07  (一社)日本消化器外科学会
  • 大腸pSM癌に対して内視鏡的切除を先行することは長期予後に影響を与えるか 追加切除、初回手術例での比較検討
    伊藤 誉, 堀江 久永, 佐田友 藍, 田原 真紀子, 清水 徹一郎, 直井 大志, 巷野 佳彦, 森 和亮, 田中 宏幸, 井上 賢之, 森本 光昭, 鯉沼 広治, 宮倉 安幸, 佐田 尚宏, 安田 是和
    日本大腸肛門病学会雑誌  2015/06  (一社)日本大腸肛門病学会
  • 腹腔鏡下スリーブ状胃切除術を施行したクラインフェルター症候群の1例
    春田 英律, 細谷 好則, 石橋 俊, 斎藤 心, 倉科 憲太郎, 宇井 崇, 松本 志郎, 安部 望, 金丸 理人, 佐田 尚宏
    日本肥満症治療学会学術集会プログラム・抄録集  2015/06  日本肥満症治療学会
  • NASH大量肝切除に対する間葉系幹細胞分泌因子の肝再生促進機序の解析
    笠原 尚哉, 土井 淳司, 寺谷 工, 藤本 康弘, 佐田 尚宏, 上本 伸二, 安田 是和, 小林 英司
    日本肝胆膵外科学会・学術集会プログラム・抄録集  2015/06  (一社)日本肝胆膵外科学会
  • Resectability向上を目指した術前固有肝動脈塞栓療法
    三木 厚, 佐久間 康成, 森嶋 計, 笹沼 秀紀, 佐田 尚宏, 安田 是和
    日本肝胆膵外科学会・学術集会プログラム・抄録集  2015/06  (一社)日本肝胆膵外科学会
  • 幽門輪温存膵頭十二指腸切除術術後のドレーンアミラーゼと膵液瘻の検討  [Not invited]
    小泉 大, 佐田 尚宏, 田口 昌延, 笠原 尚哉, 森嶋 計, 三木 厚, 笹沼 英紀, 佐久間 康成, 安田 是和
    日本肝胆膵外科学会・学術集会プログラム・抄録集  2015/06  (一社)日本肝胆膵外科学会
  • 急速な発育を示した膵管内腫瘍栓を伴う破骨巨細胞型退形成性膵管癌の1例  [Not invited]
    吉田 友直, 牛尾 純, 横山 健介, 沼尾 規且, 畑中 恒, 玉田 喜一, 斉藤 倫寛, 福嶋 敬宜, 佐田 尚宏, 山本 博徳
    Progress of Digestive Endoscopy  2015/06  (一社)日本消化器内視鏡学会-関東支部
  • ISHIGURO YASUNAO, SAKUMA YASUNARI, SASANUMA HIDEKI, MORISHIMA KAZUE, SATA NAOHIRO, YASUDA YOSHIKAZU
    日本肝胆膵外科学会学術集会プログラム・抄録集(CD-ROM)  2015/06  (一社)日本肝胆膵外科学会
  • YOSHIDA ATSUSHI, MIKI ATSUSHI, MORISHIMA KAZUE, KASAHARA NAOYA, SASANUMA HIDEKI, SAKUMA YASUNARU, SATA NAOHIRO, YASUDA YOSHIKAZU
    日本肝胆膵外科学会学術集会プログラム・抄録集(CD-ROM)  2015/06  (一社)日本肝胆膵外科学会
  • SANADA YUKIHIRO, SANADA YUKIHIRO, MORISHIMA KAZUE, KASAHARA NAOYA, MIKI ATSUSHI, SASANUMA HIDEKI, SAKUMA YASUNARI, SATA NAOHIRO, YASUDA YOSHIKAZU
    日本肝胆膵外科学会学術集会プログラム・抄録集(CD-ROM)  2015/06  (一社)日本肝胆膵外科学会
  • AOKI YUICHI, MIKI ATSUSHI, MORISHIMA KAZUE, SASANUMA HIDEKI, SAKUMA YASUNARU, SATA NAOHIRO, YASUDA YOSHIKAZU
    日本肝胆膵外科学会学術集会プログラム・抄録集(CD-ROM)  2015/06  (一社)日本肝胆膵外科学会
  • ENDO KAZUHIRO, ENDO KAZUHIRO, SATA NAOHIRO, SASANUMA HIDEKI, SAKUMA YASUNARU, YASUDA YOSHIKAZU
    日本肝胆膵外科学会学術集会プログラム・抄録集(CD-ROM)  2015/06  (一社)日本肝胆膵外科学会
  • 胆管内乳頭状腫瘍(IPNB)切除例についての検討  [Not invited]
    森嶋 計, 笠原 尚哉, 石黒 保直, 兼田 裕司, 三木 厚, 黒河内 顕, 笹沼 英紀, 佐久間 康成, 佐田 尚宏, 安田 是和
    日本肝胆膵外科学会・学術集会プログラム・抄録集  2015/06  (一社)日本肝胆膵外科学会
  • SAITO AKIRA, MIKI ATSUSHI, KASAHARA NAOYA, MORISHIMA KAZUE, TAGUCHI MASANOBU, SASANUMA HIDEKI, SAKUMA YASUNARI, SATA NAOHIRO, YASUDA YOSHIKAZU
    すい臓  2015/05  日本膵臓学会
  • ISHIGURO YASUNAO, SAKUMA YASUNARI, SASANUMA HIDEKI, MORISHIMA KAZUE, SATA NAOHIRO, YASUDA YOSHIKAZU, SAITO MICHIHIRO, FUKUSHIMA NORIYOSHI
    すい臓  2015/05  日本膵臓学会
  • NAOI TAISHI, HORIE HISANAGA, SADATOMO AI, SHIMIZU TETSUICHIRO, TAHARA MAKIKO, MORI WASUKE, ITO TAKASHI, KONO YOSHIHIKO, INOUE YOSHIYUKI, MORIMOTO MITSUAKI, KOINUMA KOJI, SASANUMA HIDEKI, SAKUMA YASUNARI, SATA NAOHIRO, YASUDA YOSHIKAZU
    家族性腫よう  2015/05  日本家族性腫瘍学会
  • Solid-pseudopapillary neoplasmを合併した家族性大腸腺腫症の1例
    直井 大志, 堀江 久永, 佐田友 藍, 清水 徹一郎, 田原 真紀子, 森 和亮, 伊藤 誉, 巷野 佳彦, 井上 賢之, 森本 光昭, 鯉沼 広治, 笹沼 英紀, 佐久間 康成, 佐田 尚宏, 安田 是和
    家族性腫瘍  2015/05  日本家族性腫瘍学会
  • 75歳以上の高齢大腸癌患者における日常生活活動度評価(METs)による術後合併症発症リスクの検討
    伊藤 誉, 堀江 久永, 佐田友 藍, 清水 徹一郎, 直井 大志, 田原 真紀子, 田中 宏之, 森 和亮, 巷野 佳彦, 井上 賢之, 森本 光昭, 小泉 大, 鯉沼 広治, 宮倉 安幸, 佐田 尚宏, 安田 是和
    日本大腸肛門病学会雑誌  2015/05  (一社)日本大腸肛門病学会
  • 膵疾患の分子病態 Basics and Applications Telomere長解析によるIPMN多段階発癌解析と悪性度診断への応用  [Not invited]
    三木 厚, 佐久間 康成, 眞田 幸広, 森嶋 計, 笹沼 秀紀, 福嶋 敬宜, 田久保 海誉, 佐田 尚宏, 安田 是和
    膵臓  2015/05  日本膵臓学会
  • SAITO AKIRA, MIKI ATSUSHI, MORISHIMA KAZUE, KASAHARA NAOYA, SASANUMA HIDEKI, SAKUMA YASUNARI, SATA NAOHIRO, YASUDA YOSHIKAZU
    肝臓  2015/04  (一社)日本肝臓学会
  • 救急・外傷 右側結腸手術に対するERASプロトコール導入の短期成績
    直井 大志, 堀江 久永, 佐田友 藍, 清水 徹一郎, 田原 真紀子, 伊藤 誉, 巷野 佳彦, 田中 宏幸, 森 和亮, 井上 賢之, 森本 光昭, 鯉沼 広治, 宮倉 安幸, 佐田 尚宏, 安田 是和
    日本外科学会定期学術集会抄録集  2015/04  (一社)日本外科学会
  • 下部消化管 腹会陰式直腸切断術におけるSSI予防対策
    森 和亮, 堀江 久永, 佐田友 藍, 清水 徹一郎, 直井 大志, 田原 真紀子, 巷野 佳彦, 田中 宏幸, 伊藤 誉, 井上 賢之, 森本 光昭, 鯉沼 広治, 宮倉 安幸, 佐田 尚宏, 安田 是和
    日本外科学会定期学術集会抄録集  2015/04  (一社)日本外科学会
  • 下部消化管 進行直腸癌に対する腹腔鏡下低位前方切除は安全な手術手技か?
    堀江 久永, 鯉沼 広治, 伊藤 誉, 森本 光昭, 井上 賢之, 清水 徹一郎, 巷野 佳彦, 田原 真紀子, 直井 大志, 佐田友 藍, 森 和亮, 佐田 尚宏, 安田 是和, 宮倉 安幸, 田中 宏幸, 長谷川 芙美, 辻仲 眞康, 力山 敏樹
    日本外科学会定期学術集会抄録集  2015/04  (一社)日本外科学会
  • 下部消化管 下部進行直腸癌に対する術前化学放射線療法によるリンパ節縮小率と予後の関連及び側方郭清が省略可能な症例の検討について
    森本 光昭, 宮倉 安幸, 堀江 久永, 鯉沼 広治, 井上 賢之, 伊藤 誉, 田中 宏幸, 清水 徹一郎, 巷野 佳彦, 田原 真紀子, 直井 大志, 佐田友 藍, 佐田 尚宏, Lefor Alan, 安田 是和
    日本外科学会定期学術集会抄録集  2015/04  (一社)日本外科学会
  • 上部消化管 間質線維芽細胞が誘導する食道扁平上皮癌の細胞増殖とlapatinib耐性におけるHGF/METとFGF/FGFRの役割
    齋藤 心, 森嶋 計, 宇井 崇, 細谷 好則, 佐田 尚宏, 安田 是和, 仁木 利郎
    日本外科学会定期学術集会抄録集  2015/04  (一社)日本外科学会
  • 下部消化管 間葉系幹細胞分泌因子添加による小腸移植成績の改善
    笠原 尚哉, 寺谷 工, 土井 淳司, 藤本 康弘, 上本 伸二, 佐田 尚宏, 安田 是和, 小林 英司
    日本外科学会定期学術集会抄録集  2015/04  (一社)日本外科学会
  • 救急・外傷 当科における術後静脈血栓塞栓症(VTE)予防の現状
    清水 徹一郎, 窓岩 清治, 大森 司, 三室 淳, 西村 智, 堀江 久永, 細谷 好則, 佐田 尚宏, 安田 是和
    日本外科学会定期学術集会抄録集  2015/04  (一社)日本外科学会
  • 肝胆膵 門脈塞栓術後の99mTc-GSA-SPECTを用いた残肝機能予測の有用性  [Not invited]
    三木 厚, 佐久間 康成, 森嶋 計, 笠原 尚哉, 笹沼 英紀, 佐田 尚宏, 安田 是和
    日本外科学会定期学術集会抄録集  2015/04  (一社)日本外科学会
  • 短腸症モデルラットを用いたポリアミン摂取による治療効果の検討
    笠原 尚哉, 寺谷 工, 三木 厚, 佐久間 康成, 藤本 康弘, 上本 伸二, 佐田 尚宏, 安田 是和
    日本消化器病学会雑誌  2015/03  (一財)日本消化器病学会
  • 下部進行直腸癌に対する術前化学放射線療法によるリンパ節縮小率と予後の検討
    森本 光昭, 宮倉 安幸, 堀江 久永, 鯉沼 広治, 伊藤 誉, 田中 宏之, 佐田 尚宏, Lefor Alan, 安田 是和
    日本大腸肛門病学会雑誌  2015/02  (一社)日本大腸肛門病学会
  • KOIZUMI DAI, SATA NAOHIRO, TAGUCHI MASANOBU, KASAHARA NAOYA, MORISHIMA KAZUE, MIKI ATSUSHI, SASANUMA HIDEKI, SAKUMA YASUNARI, YASUDA YOSHIKAZU
    日本ヘルニア学会学術集会プログラム・抄録集  2015
  • 転移性横行結腸腫瘍に対して腹腔鏡下結腸右半切除術を施行した1例
    直井 大志, 宮倉 安幸, 伊藤 誉, 清水 徹一郎, 田原 真紀子, 巷野 佳彦, 田中 宏幸, 森本 光昭, 井上 賢之, 鯉沼 広治, 堀江 久永, 佐田 尚宏, 安田 是和
    日本臨床外科学会雑誌  2014/12  日本臨床外科学会
  • 小暮 亜弥子, 佐藤 敏子, 倉科 憲太郎, 村越 美穂, 荒川 由起子, 細谷 好則, 佐田 尚宏, 安田 是和
    日本病態栄養学会誌  2014/12  (一社)日本病態栄養学会
  • 喉頭から頸部食道にかけての大型有鈎義歯による食道穿孔の1手術例
    目黒 由行, 細谷 好則, 倉科 憲太郎, 瑞木 亨, 佐田 尚宏, 安田 是和
    日本臨床外科学会雑誌  2014/11  日本臨床外科学会
  • 診断から2年の経過で片側切除した両側副腎過形成の1例
    横山 美樹, 佐久間 康成, 石黒 保直, 兼田 裕司, 松本 健司, 佐田 尚宏, 安田 是和, 長坂 昌一郎, 鈴木 司, 山口 岳彦
    日本臨床外科学会雑誌  2014/11  日本臨床外科学会
  • 右側肝円索を伴う肝門部胆管癌に対して経皮経肝的門脈塞栓術後に肝切除術を行った1例  [Not invited]
    津久井 秀則, 笹沼 英紀, 佐久間 康成, 佐田 尚宏, 安田 是和
    日本臨床外科学会雑誌  2014/11  日本臨床外科学会
  • TOJO MINEYUKI, MORISHIMA KAZUE, KASAHARA NAOYA, MIKI ATSUSHI, SASANUMA HIDEKI, SAKUMA YASUNARI, SATA NAOHIRO, YASUDA YOSHIKAZU
    日本臨床外科学会雑誌  2014/10  日本臨床外科学会
  • KUROSAWA AKIRA, MORISHIMA KAZUE, KASAHARA NAOYA, MIKI ATSUSHI, SASANUMA HIDEKI, SAKUMA YASUNARI, SATA NAOHIRO, YASUDA YOSHIKAZU
    日本臨床外科学会雑誌  2014/10  日本臨床外科学会
  • AOKI YUICHI, MIKI ATSUSHI, KASAHARA NAOYA, MORISHIMA KAZUE, SASANUMA HIDEKI, SAKUMA YASUNARI, SATA NAOHIRO, YASUDA YOSHIKAZU
    日本臨床外科学会雑誌  2014/10  日本臨床外科学会
  • MORISHIMA KAZUE, KUROSAWA AKIRA, KASAHARA NAOYA, MIKI ATSUSHI, SASANUMA HIDEKI, SAKUMA YASUNARI, SATA NAOHIRO, YASUDA YOSHIKAZU
    日本臨床外科学会雑誌  2014/10  日本臨床外科学会
  • 内視鏡的整復後に腹腔鏡下手術を施行した胃軸捻転症の1例
    瑞木 亨, 眞田 幸弘, 川口 英之, 木村 有希, 関口 忠司, 細谷 好則, 佐田 尚宏, 安田 是和
    日本内視鏡外科学会雑誌  2014/10  (一社)日本内視鏡外科学会
  • 腹腔鏡下胃全摘術後再建法のトラブルとその対処法
    細谷 好則, 瑞木 亨, 斉藤 心, 倉科 憲太郎, 春田 英律, 松本 志郎, 安部 望, 宇井 崇, 佐田 尚宏, 安田 是和
    日本内視鏡外科学会雑誌  2014/10  (一社)日本内視鏡外科学会
  • 腹腔鏡補助下胃全摘術後の再建挙上空腸捻転のため再手術を施行した1例
    安部 望, 細谷 好則, 倉科 憲太郎, 春田 英律, 松本 志郎, 佐田 尚宏, 安田 是和
    日本内視鏡外科学会雑誌  2014/10  (一社)日本内視鏡外科学会
  • アルコール多飲者の嘔吐による食道破裂の2例
    金丸 理人, 細谷 好則, 小松原 利英, 森 和亮, 松本 志郎, 宇井 崇, 春田 英律, 倉科 憲太郎, 斉藤 心, 瑞木 亨, 佐久間 康成, 佐田 尚宏, 安田 是和
    日本臨床外科学会雑誌  2014/10  日本臨床外科学会
  • 腹腔鏡下直腸・胃同時切除を行った多発性GISTの1例
    伊藤 誉, 堀江 久永, 直井 大志, 森本 光昭, 鯉沼 広治, 宮倉 安幸, 佐田 尚宏, 安田 是和
    日本内視鏡外科学会雑誌  2014/10  (一社)日本内視鏡外科学会
  • 内側アプローチを意識した安全な脾彎曲部授動のコツ
    伊藤 誉, 堀江 久永, 直井 大志, 森本 光昭, 鯉沼 広治, 宮倉 安幸, 佐田 尚宏, 安田 是和
    日本内視鏡外科学会雑誌  2014/10  (一社)日本内視鏡外科学会
  • 肥満が腹腔鏡下大腸切除術に与える影響
    森本 光昭, 堀江 久永, 宮倉 安幸, 鯉沼 広治, 井上 賢之, 伊藤 誉, 田中 宏幸, 清水 徹一郎, 巷野 佳彦, 田原 真紀子, 直井 大志, 佐田友 藍, 佐田 尚宏, Alan Lefor, 安田 是和
    日本内視鏡外科学会雑誌  2014/10  (一社)日本内視鏡外科学会
  • 転移性横行結腸腫瘍に対して腹腔鏡補助下結腸右半切除術を施行した1例
    直井 大志, 堀江 久永, 伊藤 誉, 佐田友 藍, 清水 徹一郎, 田原 真紀子, 田中 宏幸, 巷野 佳彦, 鯉沼 広治, 宮倉 安幸, 佐田 尚宏, 安田 是和
    日本内視鏡外科学会雑誌  2014/10  (一社)日本内視鏡外科学会
  • 膿瘍形成を伴う高度進行直腸癌に対し術前CRTを施行しpCRが得られた1例
    宮原 悠三, 伊藤 誉, 直井 大志, 森本 光昭, 鯉沼 広治, 宮倉 安幸, 堀江 久永, 佐田 尚宏, 安田 是和
    日本臨床外科学会雑誌  2014/10  日本臨床外科学会
  • 結腸直腸癌におけるアセトアミノフェン静注製剤による術後鎮痛の試み
    直井 大志, 倉科 憲太郎, 井上 莊一郎, 平 幸輝, 伊藤 誉, 田中 宏幸, 森本 光昭, 清水 徹一郎, 巷野 佳彦, 鯉沼 広治, 宮倉 安幸, 堀江 久永, 細谷 好則, 佐田 尚宏, 安田 是和
    日本臨床外科学会雑誌  2014/10  日本臨床外科学会
  • 進行直腸癌に対する側方郭清の意義 直腸癌術前化学放射線療法後の側方郭清について
    森本 光昭, 堀江 久永, 宮倉 安幸, 鯉沼 広治, 井上 賢之, 伊藤 誉, 田中 宏幸, 清水 徹一郎, 巷野 佳彦, 田原 真紀子, 直井 大志, 佐田友 藍, 佐田 尚宏, Lefor Alan, 安田 是和
    日本臨床外科学会雑誌  2014/10  日本臨床外科学会
  • インスリノーマの局在診断における造影早期相thin slice CT撮影の有用性
    石岡 秀基, 石黒 保直, 森嶋 計, 三木 厚, 兼田 裕司, 黒河内 顕, 笹沼 英紀, 佐久間 康成, 佐田 尚宏, 安田 是和
    日本消化器外科学会雑誌  2014/10  (一社)日本消化器外科学会
  • 当科における肝細胞癌初回切除症例116例の予後についての検討
    石黒 保直, 佐久間 康成, 笹沼 英紀, 藤原 岳人, 黒河内 顕, 三木 厚, 兼田 裕司, 森嶋 計, 佐田 尚宏, 安田 是和
    日本消化器外科学会雑誌  2014/10  (一社)日本消化器外科学会
  • SASANUMA HIDEKI, SATA NAOHIRO, MORISHIMA KAZUE, KASAHARA NAOYA, MIKI ATSUSHI, SAKUMA YASUNARI, YASUDA YOSHIKAZU
    日本内視鏡外科学会雑誌  2014/10  (一社)日本内視鏡外科学会
  • SAKUMA YASUNARI, TAKAYAMA TATSUYA, TAKEI YUJI, TEZUKA NORIYUKI, SASANUMA HIDEKI, MORISHIMA KAZUE, NIWA YASUNORI, HORIE HISANAGA, HOSOYA YOSHINORI, SATA NAOHIRO, YASUDA YOSHIKAZU
    日本内視鏡外科学会雑誌  2014/10  (一社)日本内視鏡外科学会
  • SAITO AKIRA, MIKI ATSUSHI, MORISHIMA KAZUE, KASAHARA NAOYA, SASANUMA HIDEKI, SAKUMA YASUNARI, SATA NAOHIRO, YASUDA YOSHIKAZU
    日本膵・胆管合流異常研究会プロシーディングス  2014/09  日本膵・胆管合流異常研究会
  • 胃癌・大腸癌手術症例に併存する膵嚢胞性病変の検討  [Not invited]
    小泉 大, 佐田 尚宏, 田口 昌延, 森嶋 計, 石黒 保直, 兼田 裕司, 三木 敦, 黒河内 顕, 笹沼 英紀, 佐久間 康成, 堀江 久永, 細谷 好則, 安田 是和
    日本消化器病学会雑誌  2014/09  (一財)日本消化器病学会
  • AOKI YUICHI, SASANUMA HIDEKI, KASAHARA NAOYA, MORISHIMA KAZUE, MIKI ATSUSHI, SAKUMA YASUNARI, SATA NAOHIRO, YASUDA YOSHIKAZU
    胆道  2014/08  日本胆道学会
  • YOSHIDA JUN, SAKUMA YASUNARI, MORISHIMA KAZUE, KASAHARA NAOYA, MIKI ATSUSHI, SASANUMA HIDEKI, SATA NAOHIRO, YASUDA YOSHIKAZU
    小切開・鏡視外科学会雑誌  2014/08  (NPO)小切開・鏡視外科学会
  • TOJO MINEYUKI, ABE NOZOMI, MORISHIMA KAZUE, MORIMOTO MITSUAKI, SASANUMA HIDEKI, SAKUMA YASUNARI, SATA NAOHIRO, YASUDA YOSHIKAZU
    小切開・鏡視外科学会雑誌  2014/08  (NPO)小切開・鏡視外科学会
  • 自治医科大学におけるマルチメディア形式の総合判定試験の導入  [Not invited]
    松山 泰, 石川 鎮清, 岸 浩一郎, 矢野 晴美, 武藤 弘行, 佐田 尚宏, 岡崎 仁昭
    医学教育  2014/07  (一社)日本医学教育学会
  • 食道バイパス術後に挙上胃管壊死をきたし遊離空腸再建術を行った食道癌CRT後の症例
    春田 英律, 細谷 好則, 金丸 理人, 安部 望, 松本 志郎, 倉科 憲太郎, 瑞木 亨, 斎藤 心, 佐田 尚宏, 安田 是和
    日本食道学会学術集会プログラム・抄録集  2014/07  (NPO)日本食道学会
  • 当院における腹腔鏡下スリーブ状胃切除術の成績と課題
    春田 英律, 細谷 好則, 石橋 俊, 瑞木 亨, 斎藤 心, 倉科 憲太郎, 松本 志郎, 安部 望, 金丸 理人, 佐田 尚宏, 安田 是和
    日本肥満症治療学会学術集会プログラム・抄録集  2014/07  日本肥満症治療学会
  • 肛門管Neuroendocrine carcinomaの一切除例
    直井 大志, 伊藤 誉, 宮倉 安幸, 鯉沼 広治, 井上 賢之, 森本 光昭, 田中 宏幸, 堀江 久永, 佐田 尚宏, 安田 是和
    日本消化器外科学会総会  2014/07  (一社)日本消化器外科学会
  • 成人腸重積症の検討
    田中 宏幸, 宮倉 安幸, 下平 健太郎, 伊藤 誉, 森本 光昭, 鯉沼 広治, 堀江 久永, 細谷 好則, 佐田 尚宏, 安田 是和
    日本消化器外科学会総会  2014/07  (一社)日本消化器外科学会
  • 吻合部内視鏡所見からみたクローン病術後の治療戦略
    伊藤 誉, 宮倉 安幸, 直井 大志, 田中 宏幸, 井上 賢之, 森本 光昭, 鯉沼 広治, 堀江 久永, 佐田 尚宏, 安田 是和
    日本消化器外科学会総会  2014/07  (一社)日本消化器外科学会
  • 幽門輪温存膵頭十二指腸切除術後のドレーン排液アミラーゼによるドレーン管理  [Not invited]
    小泉 大, 佐田 尚宏, 森 和亮, 森嶋 計, 石黒 保直, 兼田 裕司, 三木 厚, 笹沼 英紀, 佐久間 康成, 安田 是和
    日本消化器外科学会総会  2014/07  (一社)日本消化器外科学会
  • 中部胆管癌に対する肝外胆管切除術の適応  [Not invited]
    松本 志郎, 佐田 尚宏, 兼田 裕司, 三木 厚, 石黒 保直, 黒河内 顕, 小泉 大, 笹沼 英紀, 佐久間 康成, 安田 是和
    日本消化器外科学会総会  2014/07  (一社)日本消化器外科学会
  • 肝門部胆管癌術後の放射線治療の検討  [Not invited]
    森嶋 計, 佐久間 康成, 三木 厚, 兼田 裕司, 石黒 保直, 黒河内 顕, 笹沼 英紀, 佐田 尚宏, 安田 是和
    日本消化器外科学会総会  2014/07  (一社)日本消化器外科学会
  • 肝細胞癌肝切除症例に対する残肝機能測定とリスク評価  [Not invited]
    三木 厚, 佐久間 康成, 森島 計, 石黒 保直, 兼田 裕司, 黒河内 顕, 笹沼 英紀, 佐田 尚宏, 安田 是和
    日本消化器外科学会総会  2014/07  (一社)日本消化器外科学会
  • SATA NAOHIRO, MORISHIMA KAZUE, ISHIGURO YASUNAO, KANEDA YUJI, KUROKOUCHI KEN, ENDO KAZUHIRO, KOIZUMI DAI, SASANUMA HIDEKI, SAKUMA YASUNARI, YASUDA YOSHIKAZU
    すい臓  2014/06
  • KUROKOUCHI KEN, SATA NAOHIRO, MORISHIMA KAZUE, ISHIGURO YASUNAO, MIKI ATSUSHI, KANEDA YUJI, ENDO KAZUHIRO, KOIZUMI DAI, SASANUMA HIDEKI, SAKUMA YASUNARI, YASUDA YOSHIKAZU
    すい臓  2014/06  日本膵臓学会
  • 佐田 尚宏, 森嶋 計, 石黒 保直, 兼田 裕司, 黒河内 顕, 遠藤 和洋, 小泉 大, 笹沼 英紀, 佐久間 康成, 安田 是和
    膵臓  2014/06  (一社)日本膵臓学会
  • 右肝動脈血行再建を行った固有肝動脈瘤破裂の一例
    本間 祐子, 佐久間 康成, 安部 望, 森本 光昭, 森嶋 計, 黒河内 顕, 岡田 憲樹, 菱川 修司, 佐田 尚宏, 安田 是和
    日本肝胆膵外科学会・学術集会プログラム・抄録集  2014/06  (一社)日本肝胆膵外科学会
  • 胆管空腸吻合における縫合不全ゼロを目指した当科の工夫 全層一層連続縫合による胆管空腸吻合術
    兼田 裕司, 佐田 尚宏, 田口 昌延, 森嶋 計, 石黒 保直, 三木 厚, 小泉 大, 笹沼 英紀, 佐久間 康成, 安田 是和
    日本肝胆膵外科学会・学術集会プログラム・抄録集  2014/06  (一社)日本肝胆膵外科学会
  • KOIZUMI MASARU, SATA NAOHIRO, TAGUCHI MASANOBU, MORISHIMA KAZUE, ISHIGURO YASUNAO, KANEDA YUJI, MIKI ATSUSHI, KUROGOUCHI AKIRA, SASANUMA HIDEKI, SAKUMA YASUNARI, YASUDA YOSHIKAZU
    日本肝胆膵外科学会学術集会プログラム・抄録集(CD-ROM)  2014/06  (一社)日本肝胆膵外科学会
  • ISHIGURO YASUNAO, SAKUMA YASUNARI, SASANUMA HIDEKI, SATA NAOHIRO, YASUDA YOSHIKAZU
    日本肝胆膵外科学会学術集会プログラム・抄録集(CD-ROM)  2014/06  (一社)日本肝胆膵外科学会
  • KANEDA YUJI, SATA NAOHIRO, TAGUCHI MASANOBU, MORISHIMA KAZUE, ISHIGURO YASUNAO, MIKI ATSUSHI, KOIZUMI MASARU, SASANUMA HIDEKI, SAKUMA YASUNARU, YASUDA YOSHIKAZU
    日本肝胆膵外科学会学術集会プログラム・抄録集(CD-ROM)  2014/06  (一社)日本肝胆膵外科学会
  • TAGUCHI MASANOBU, SANADA YUKIHIRO, KASAHARA NAOYA, MORISHIMA KAZUE, ISHIGURO YASUNAO, KANEDA YUJI, MIKI ATSUSHI, KUROGOUCHI AKIRA, ENDO KAZUHIRO, KOIZUMI MASARU, SASANUMA HIDEKI, FUJIWARA TAKETO, SAKUMA YASUNARI, SHIMIZU ATSUSHI, HYODO MASANOBU, SATA NAOHIRO, YASUDA YOSHIKAZU
    日本肝胆膵外科学会学術集会プログラム・抄録集(CD-ROM)  2014/06  (一社)日本肝胆膵外科学会
  • KOBAYASHI HISAYA, MIKI ATSUSHI, MORISHIMA KAZUE, KANEDA YUJI, ISHIGURO YASUNAO, KUROGOUCHI AKIRA, SASANUMA HIDEKI, SAKUMA YASUNARI, SATA NAOHIRO, YASUDA YOSHIKAZU
    日本肝胆膵外科学会学術集会プログラム・抄録集(CD-ROM)  2014/06  (一社)日本肝胆膵外科学会
  • 胆管内乳頭状腫瘍(IPNB)切除例の検討  [Not invited]
    森嶋 計, 佐久間 康成, 石黒 保直, 兼田 裕司, 三木 厚, 黒河内 顕, 笹沼 英紀, 佐田 尚宏, 安田 是和
    日本肝胆膵外科学会・学術集会プログラム・抄録集  2014/06  (一社)日本肝胆膵外科学会
  • 原発性十二指腸癌のムチンタンパク発現による臨床病理的解析  [Not invited]
    三木 厚, 佐久間 康成, 笹沼 英紀, 黒河内 顕, 兼田 祐司, 石黒 保直, 森島 計, 佐田 尚宏, 安田 是和
    日本肝胆膵外科学会・学術集会プログラム・抄録集  2014/06  (一社)日本肝胆膵外科学会
  • 当科における術後静脈血栓塞栓症(VTE)予防の現状
    清水 徹一郎, 窓岩 清治, 大森 司, 三室 淳, 西村 智, 坂田 洋一, 堀江 久永, 細谷 好則, 佐田 尚宏, 安田 是和
    日本血栓止血学会誌  2014/04  (一社)日本血栓止血学会
  • 清水 徹一郎, 宮倉 安幸, 田原 真紀子, 巷野 佳彦, 田中 宏幸, 伊藤 誉, 井上 賢之, 森本 光昭, 鯉沼 広治, 堀江 久永, 佐田 尚宏, 安田 是和
    日本外科学会雑誌  2014/03  一般社団法人日本外科学会
  • 伊藤 誉, 宮倉 安幸, 倉科 憲太郎, 小泉 大, 鯉沼 広治, 瑞木 享, 堀江 久永, 細谷 好則, 佐田 尚宏, 安田 是和
    日本外科学会雑誌  2014/03  一般社団法人日本外科学会
  • KOIZUMI DAI, SATA NAOHIRO, SANADA YUKIHIRO, TAGUCHI MASANOBU, ISHIGURO YASUNAO, KANEDA YUJI, MIKI ATSUSHI, KUROKOUCHI KEN, ENDO KAZUHIRO, SASANUMA HIDEKI, SAKUMA YASUNARI, OTA MAKOTO, LEFOR ALAN, YASUDA YOSHIKAZU
    日本外科学会雑誌  2014/03  (一社)日本外科学会
  • 小泉 大, 佐田 尚宏, 眞田 幸弘, 田口 昌延, 石黒 保直, 兼田 裕司, 三木 厚, 黒河内 顕, 遠藤 和洋, 笹沼 英紀, 佐久間 康成, 太田 真, Lefor Alan, 安田 是和
    日本外科学会雑誌  2014/03  一般社団法人日本外科学会
  • 伊藤 誉, 宮倉 安幸, 倉科 憲太郎, 小泉 大, 鯉沼 広治, 瑞木 享, 堀江 久永, 細谷 好則, 佐田 尚宏, 安田 是和
    日本外科学会雑誌  2014/03  (一社)日本外科学会
  • 清水 徹一郎, 宮倉 安幸, 田原 真紀子, 巷野 佳彦, 田中 宏幸, 伊藤 誉, 井上 賢之, 森本 光昭, 鯉沼 広治, 堀江 久永, 佐田 尚宏, 安田 是和
    日本外科学会雑誌  2014/03  (一社)日本外科学会
  • 胃切除術後6年目に発症した脚気ニューロパチー、衝心脚気の1例
    春田 英律, 細谷 好則, 倉科 憲太郎, 宇井 崇, 瑞木 亨, 松本 志郎, 金丸 理人, 佐田 尚宏, 安田 是和
    静脈経腸栄養  2014/01  (株)ジェフコーポレーション
  • KURASHINA KENTARO, MATSUMOTO SHIRO, UI TAKASHI, SASANUMA HIDEKI, HARUTA HIDENORI, ABE NOZOMI, KANAMARU MASATO, HOSOYA YOSHINORI, SATA NAOHIRO, YASUDA YOSHIKAZU
    PEG・在宅医療研究会学術集会プログラム抄録集  2014
  • LATGおよびLAPGの食道空腸吻合DST再建後の狭窄に関する検討
    瑞木 亨, 細谷 好則, 倉科 憲太郎, 齋藤 心, 宇井 崇, 春田 英律, 佐田 尚宏, 安田 是和
    日本内視鏡外科学会雑誌  2013/11  (一社)日本内視鏡外科学会
  • 当科での段階的な鏡視下手術トレーニングの運用  [Not invited]
    佐久間 康成, 笹沼 英紀, 俵藤 正信, 小泉 大, 宮倉 安幸, 堀江 久永, 細谷 好則, Alan Lefor, 佐田 尚宏, 安田 是和
    日本内視鏡外科学会雑誌  2013/11  (一社)日本内視鏡外科学会
  • 膵壊死部感染  [Not invited]
    SATA NAOHIRO, KANEDA YUJI, ENDO KAZUHIRO, KOIZUMI MASARU, SASANUMA HIDEKI, SAKUMA YASUNARI, YASUDA YOSHIKAZU
    日本外科感染症学会雑誌  2013/10
  • KANEDA YUJI, SATA NAOHIRO, TAGUCHI MASANOBU, MORI WASUKE, ISHIGURO YASUNAO, ENDO KAZUHIRO, KOIZUMI DAI, SASANUMA HIDEKI, SAKUMA YASUNARI, HYODO MASANOBU, YASUDA YOSHIKAZU
    日本臨床外科学会雑誌  2013/10  日本臨床外科学会
  • MORI WASUKE, SASANUMA HIDEKI, TAGUCHI MASANOBU, MORISHIMA KAZUE, ISHIGURO YASUNAO, KANEDA YUJI, ENDO KAZUHIRO, KOIZUMI DAI, SAKUMA YASUNARI, SATA NAOHIRO, YASUDA YOSHIKAZU
    日本臨床外科学会雑誌  2013/10  日本臨床外科学会
  • 膵頭十二指腸切除術後の膵液瘻予防を目指した当科の対策 Blumgart変法による膵空腸吻合術
    兼田 裕司, 佐田 尚宏, 田口 昌延, 森 和亮, 石黒 保直, 遠藤 和洋, 小泉 大, 笹沼 英紀, 佐久間 康成, 俵藤 正信, 安田 是和
    日本臨床外科学会雑誌  2013/10  日本臨床外科学会
  • 佐田 尚宏, 兼田 裕司, 遠藤 和洋, 小泉 大, 笹沼 英紀, 佐久間 康成, 安田 是和
    日本外科感染症学会雑誌  2013/10  (一社)日本外科感染症学会
  • 高齢者に対する癌治療方針(大腸) 80歳以上の高齢大腸癌患者におけるMetabolic equivalentsを用いた日常生活活動度評価による術後合併症発症リスクの検討
    伊藤 誉, 宮倉 安幸, 清水 徹一郎, 田原 真紀子, 巷野 佳彦, 井上 賢之, 森本 光昭, 小泉 大, 鯉沼 広治, 堀江 久永, 佐田 尚宏, 安田 是和
    日本臨床外科学会雑誌  2013/10  日本臨床外科学会
  • 当科における術後静脈血栓塞栓症予防の現状
    清水 徹一郎, 窓岩 清治, 大森 司, 三室 淳, 堀江 久永, 細谷 好則, 佐田 尚宏, 安田 是和
    日本臨床外科学会雑誌  2013/10  日本臨床外科学会
  • TANIGUCHI MASATAKE, SAKUMA YASUNARI, ISHIGURO YASUNAO, ENDO KAZUHIRO, SASANUMA HIDEKI, KOIZUMI DAI, SATA NAOHIRO, YASUDA YOSHIKAZU
    日本臨床外科学会雑誌  2013/09  日本臨床外科学会
  • 田口 昌延, 出崎 克也, 服部 智久, 春田 英律, 小泉 大, 細谷 好則, 佐田 尚宏, 安田 是和, 矢田 俊彦
    肥満研究  2013/09  (一社)日本肥満学会
  • 小泉 大, 高橋 大二郎, 松本 志郎, 高岡 良成, 大橋 明, 木口 英子, 佐田 尚宏, 近藤 泰雄
    胆道  2013/08  日本胆道学会
  • 牛尾純, 沼尾規且, 畑中恒, 遠藤和洋, 鈴木司, 玉田喜一, 佐田尚宏, 福嶋敬宜, 菅野健太郎
    日本消化器画像診断研究会プログラム・抄録集  2013/08
  • ANDO NAOKATSU, SANADA YUKIHIRO, SAKUMA YASUNARI, ENDO KAZUHIRO, SASANUMA HIDEKI, SHIMIZU ATSUSHI, SATA NAOHIRO, YASUDA YOSHIKAZU
    日本臨床外科学会雑誌  2013/07  日本臨床外科学会
  • 選択必修BSLにおける院外拠点病院実習ポストアンケート2年間の結果  [Not invited]
    石川 鎮清, 佐田 尚宏, 岡崎 仁昭
    医学教育  2013/07  (一社)日本医学教育学会
  • 薬剤部分耐性胃GISTに対して2度の外科的切除を施行した1例
    目黒 由行, 細谷 好則, 瑞木 亨, 清水 敦, 福嶋 敬宣, 藤井 博文, 佐田 尚宏, 安田 是和
    日本臨床外科学会雑誌  2013/07  日本臨床外科学会
  • 開腹胃全摘と腹腔鏡補助下胃全摘におけるDAUGS32による術後機能障害評価とQOL評価の差異
    瑞木 亨, 細谷 好則, 倉科 憲太郎, 齋藤 心, 宇井 崇, 春田 英律, 段ノ上 秀雄, 中村 美鈴, 佐田 尚宏, 安田 是和
    日本消化器外科学会総会  2013/07  (一社)日本消化器外科学会
  • 生体肝移植ドナーの安全性向上における間葉系幹細胞応用に向けた取り組み
    笠原 尚哉, 土井 淳司, 寺谷 工, 藤本 康弘, 佐田 尚宏, 上本 伸二, 小林 英司
    日本消化器外科学会総会  2013/07  (一社)日本消化器外科学会
  • 当院にて手術施行した十二指腸水平部癌の4例  [Not invited]
    青木 裕一, 佐久間 康成, 三木 厚, 石黒 保直, 遠藤 和洋, 笹沼 英紀, 佐田 尚宏, 安田 是和
    日本消化器外科学会総会  2013/07  (一社)日本消化器外科学会
  • 膵頭十二指腸切除後胆管炎・胆管狭窄に対する治療戦略  [Not invited]
    三木 厚, 佐久間 康成, 笹沼 英紀, 遠藤 和洋, 兼田 裕司, 佐田 尚宏, 安田 是和
    日本消化器外科学会総会  2013/07  (一社)日本消化器外科学会
  • 当科における膵内分泌細胞腫瘍10例のまとめ  [Not invited]
    石黒 保直, 佐久間 康成, 笹沼 英紀, 遠藤 和洋, 佐田 尚宏, 安田 是和
    日本消化器外科学会総会  2013/07  (一社)日本消化器外科学会
  • Interactiveな手術simulationおよびnavigation virtual及びreal 3D modelによる治療支援と教育的活用  [Not invited]
    遠藤 和洋, 佐田 尚宏, 眞田 幸弘, 兼田 裕司, 石黒 保直, 笹沼 英紀, 佐久間 康成, 安田 是和
    日本消化器外科学会総会  2013/07  (一社)日本消化器外科学会
  • 膵Intraductal Papillary Mucinous Neoplasm(IPMN)の手術適応と至適術式 膵切離断端からみた膵IPMN切除術式の検討  [Not invited]
    笹沼 英紀, 佐田 尚宏, 兼田 裕司, 石黒 保直, 遠藤 和洋, 小泉 大, 佐久間 康成, 福嶋 敬宜, 安田 是和
    日本消化器外科学会総会  2013/07  (一社)日本消化器外科学会
  • 幽門輪温存膵頭十二指腸切除術後のドレーン排液アミラーゼと抜去時期に関する検討  [Not invited]
    小泉 大, 佐田 尚宏, 森 和亮, 田口 昌延, 笠原 尚哉, 兼田 裕司, 遠藤 和洋, 笹沼 英紀, 佐久間 康成, 安田 是和
    日本消化器外科学会総会  2013/07  (一社)日本消化器外科学会
  • 当院における膵癌切除術後の長期生存症例に関する検討  [Not invited]
    兼田 裕司, 佐田 尚宏, 田口 昌延, 笠原 尚哉, 森嶋 計, 遠藤 和洋, 小泉 大, 笹沼 英紀, 佐久間 康成, 安田 是和
    日本消化器外科学会総会  2013/07  (一社)日本消化器外科学会
  • MIKI ATSUSHI, SAKUMA YASUNARI, ENDO KAZUHIRO, SASANUMA HIDEKI, SATA NAOHIRO, YASUDA YOSHIKAZU
    すい臓  2013/06
  • TANAKA YUMIKO, SAKUMA YASUNARI, MORI WASUKE, ENDO KAZUHIRO, SASANUMA HIDEKI, SATA NAOHIRO, YASUDA YOSHIKAZU
    すい臓  2013/06  日本膵臓学会
  • SADATOMO AI, KANEDA YUJI, ENDO KAZUHIRO, KOIZUMI MASARU, SASANUMA HIDEKI, SAKUMA YASUNARI, SATA NAOHIRO, YASUDA YOSHIKAZU
    すい臓  2013/06  日本膵臓学会
  • MORI KAZUAKI, SASANUMA HIDEKI, TAGUCHI MASANOBU, MORISHIMA KAZUE, KANEDA YUJI, ENDO KAZUHIRO, KOIZUMI DAI, SAKUMA YASUNARI, SHIMIZU ATSUSHI, SATA NAOHIRO, YASUDA YOSHIKAZU
    すい臓  2013/06  日本膵臓学会
  • KUROKOUCHI KEN, SATA NAOHIRO, ENDO KAZUHIRO, KANEDA YUJI, KOIZUMI DAI, SASANUMA HIDEKI, YASUDA YOSHIKAZU
    すい臓  2013/06  日本膵臓学会
  • ISHIGURO YASUNAO, SAKUMA YASUNARI, MORISHIMA KAZUE, KASAHARA NAOYA, TAGUCHI MASANOBU, KANEDA YUJI, ENDO KAZUHIRO, SASANUMA HIDEKI, KOIZUMI DAI, SATA NAOHIRO, YASUDA YOSHIKAZU
    すい臓  2013/06  日本膵臓学会
  • 食道癌肉腫手術症例の検討
    瑞木 亨, 細谷 好則, 齋藤 心, 倉科 憲太郎, 宇井 崇, 春田 英律, 松本 志郎, 佐田 尚宏, 安田 是和, 福島 敬宜
    日本食道学会学術集会プログラム・抄録集  2013/06  (NPO)日本食道学会
  • 当院における腹腔鏡下スリーブ状胃切除術の成績
    春田 英律, 細谷 好則, 石橋 俊, 多賀谷 信美, 瑞木 亨, 斎藤 心, 倉科 憲太郎, 松本 志郎, 佐田 尚宏, 安田 是和
    日本肥満症治療学会学術集会プログラム・抄録集  2013/06  日本肥満症治療学会
  • NASH大量肝切除に対する間葉系幹細胞分泌因子の有効性について
    笠原 尚哉, 土井 淳司, 寺谷 工, 藤本 康弘, 佐田 尚宏, 上本 伸二, 安田 是和, 小林 英司
    日本肝胆膵外科学会・学術集会プログラム・抄録集  2013/06  (一社)日本肝胆膵外科学会
  • 膵消化管吻合法の工夫 幽門輪温存膵頭十二指腸切除術における前壁切開膵胃吻合法の工夫
    小泉 大, 佐田 尚宏, 田口 昌延, 笠原 尚哉, 兼田 裕司, 遠藤 和洋, 笹沼 英紀, 佐久間 康成, 安田 是和
    日本肝胆膵外科学会・学術集会プログラム・抄録集  2013/06  (一社)日本肝胆膵外科学会
  • ENDO KAZUHIRO, SATA NAOHIRO, ISHIGURO YASUNAO, KANEDA YUJI, SASANUMA HIDEKI, SAKUMA YASUNARI, YASUDA YOSHIKAZU
    日本肝胆膵外科学会・学術集会プログラム・抄録集  2013/06  (一社)日本肝胆膵外科学会
  • SASANUMA HIDEKI, SAKUMA YASUNARI, SANADA YUKIHIRO, FUJIWARA TAKEHITO, SHIMIZU ATSUSHI, HYODO MASANOBU, MIZUTA KOICHI, SATA NAOHIRO, YASUDA YOSHIKAZU
    日本肝胆膵外科学会・学術集会プログラム・抄録集  2013/06  (一社)日本肝胆膵外科学会
  • SANADA YUKIHIRO, YAMADA NAOYA, KANEDA YUJI, ENDO KAZUHIRO, KOIZUMI DAI, SASANUMA HIDEKI, SAKUMA YASUNARI, SHIMIZU ATSUSHI, SATA NAOHIRO, YASUDA YOSHIKAZU
    日本肝胆膵外科学会・学術集会プログラム・抄録集  2013/06  (一社)日本肝胆膵外科学会
  • SAKUMA YASUNARI, SASANUMA HIDEKI, ENDO KAZUHIRO, SHIMIZU ATSUSHI, HYODO MASANOBU, SANADA YUKIHIRO, ISHIGURO YASUNAO, SATA NAOHIRO, YASUDA YOSHIKAZU
    日本肝胆膵外科学会・学術集会プログラム・抄録集  2013/06  (一社)日本肝胆膵外科学会
  • SHIMIZU ATSUSHI, HYODO MASANOBU, SAKUMA YASUNARI, FUJIWARA TAKEHITO, SASANUMA HIDEKI, ENDO KAZUHIRO, ISHIGURO YASUNAO, SANADA YUKIHIRO, KANEDA YUJI, MORISHIMA KAZUE, MIKI ATSUSHI, KASAHARA NAOYA, TAGUCHI MASANOBU, YAMASHITA KEISUKE, SATA NAOHIRO, YASUDA YOSHIKAZU
    日本肝胆膵外科学会・学術集会プログラム・抄録集  2013/06  (一社)日本肝胆膵外科学会
  • 膵仮性嚢胞に対する嚢胞胃吻合術の工夫  [Not invited]
    石黒 保直, 遠藤 和洋, 森嶋 計, 笠原 直哉, 田口 昌延, 兼田 裕司, 笹沼 英紀, 小泉 大, 佐久間 康成, 清水 敦, 佐田 尚宏, 安田 是和
    日本肝胆膵外科学会・学術集会プログラム・抄録集  2013/06  (一社)日本肝胆膵外科学会
  • 急性膵炎・慢性膵炎に対する内視鏡・腹腔鏡治療の最前線 Walled-off pancreatic necrosisに対する内視鏡的ネクロセクトミー  [Not invited]
    安田 一朗, 中島 賢憲, 岩井 知久, 伊佐山 浩通, 糸井 隆夫, 久居 弘幸, 井上 宏之, 加藤 博也, 菅野 敦, 窪田 賢輔, 入澤 篤志, 五十嵐 久人, 岡部 義信, 北野 雅之, 河上 洋, 林 毅, 向井 強, 佐田 尚宏, 木田 光弘, 下瀬川 徹, JENIPaN studyグループ
    膵臓  2013/06  日本膵臓学会
  • TAKAGI TOORU, SAKUMA YASUNARI, ENDO KAZUHIRO, SASANUMA HIDEKI, SATA NAOHIRO, YASUDA KOREKAZU
    日本内分泌外科学会総会プログラム・抄録集  2013/05  日本内分泌外科学会
  • 三木 厚, 佐久間 康成, 佐田 尚宏, 安田 是和
    日本外科学会雑誌  2013/03  一般社団法人日本外科学会
  • 瑞木 亨, 細谷 好則, 佐久間 康成, 俵藤 正信, 倉科 憲太郎, 宇井 崇, 春田 英律, 齋藤 心, 佐田 尚宏, 安田 是和
    日本外科学会雑誌  2013/03  一般社団法人日本外科学会
  • 清水 徹一郎, 堀江 久永, 細谷 好則, 佐田 尚宏, 安田 是和, 窓岩 清治, 大森 司, 三室 淳, 篠原 貴子, 丹羽 康則
    日本外科学会雑誌  2013/03  一般社団法人日本外科学会
  • 笠原 尚哉, 寺谷 工, 前田 雅志, 土井 淳司, 佐田 尚宏, 安田 是和, 小林 英司
    日本外科学会雑誌  2013/03  一般社団法人日本外科学会
  • 齋藤 心, 森嶋 計, 宇井 崇, 細谷 好則, 佐田 尚宏, 安田 是和
    日本外科学会雑誌  2013/03  一般社団法人日本外科学会
  • KOIZUMI DAI, SATA NAOHIRO, TAGUCHI MASANOBU, KASAHARA NAOYA, ISHIGURO YASUNAO, ENDO KAZUHIRO, SASANUMA HIDEKI, SAKUMA YASUNARI, SHIMIZU ATSUSHI, YASUDA YOSHIKAZU
    日本外科学会雑誌  2013/03  (一社)日本外科学会
  • SASANUMA HIDEKI, FUJIWARA TAKEHITO, SANADA YUKIHIRO, SAKUMA YASUNARI, SHIMIZU ATSUSHI, HYODO MASANOBU, MIZUTA KOICHI, SATA NAOHIRO, YASUDA YOSHIKAZU
    日本外科学会雑誌  2013/03  (一社)日本外科学会
  • SHIMIZU ATSUSHI, SAKUMA YASUNARI, SASANUMA HIDEKI, ENDO KAZUHIRO, KOIZUMI DAI, HYODO MASANOBU, FUJIWARA TAKEHITO, SANADA YUKIHIRO, KANEDA YUJI, MIKI ATSUSHI, MORISHIMA KAZUE, KASAHARA NAOYA, TAGUCHI MASANOBU, SATA NAOHIRO, YASUDA YOSHIKAZU
    日本外科学会雑誌  2013/03  (一社)日本外科学会
  • 笹沼 英紀, 藤原 岳人, 眞田 幸弘, 佐久間 康成, 清水 敦, 俵藤 正信, 水田 耕一, 佐田 尚宏, 安田 是和
    日本外科学会雑誌  2013/03  一般社団法人日本外科学会
  • 佐久間 康成, 藤原 岳人, 笹沼 英記, 清水 敦, 俵藤 正信, 佐田 尚宏, 真田 幸弘, 井原 欣幸, 浦橋 泰然, 水田 耕一, 安田 是和
    日本外科学会雑誌  2013/03  一般社団法人日本外科学会
  • 小泉 大, 佐田 尚宏, 田口 昌延, 笠原 尚哉, 石黒 保直, 遠藤 和洋, 笹沼 英紀, 佐久間 康成, 清水 敦, 安田 是和
    日本外科学会雑誌  2013/03  一般社団法人日本外科学会
  • 清水 敦, 佐久間 康成, 笹沼 英紀, 遠藤 和洋, 小泉 大, 俵藤 正信, 藤原 岳人, 眞田 幸弘, 兼田 裕司, 三木 厚, 森嶋 計, 笠原 尚哉, 田口 昌延, 佐田 尚宏, 安田 是和
    日本外科学会雑誌  2013/03  一般社団法人日本外科学会
  • 佐久間 康成, 藤原 岳人, 笹沼 英記, 清水 敦, 俵藤 正信, 佐田 尚宏, 真田 幸弘, 井原 欣幸, 浦橋 泰然, 水田 耕一, 安田 是和
    日本外科学会雑誌  2013/03  一般社団法人日本外科学会
  • 瑞木 亨, 細谷 好則, 佐久間 康成, 俵藤 正信, 倉科 憲太郎, 宇井 崇, 春田 英律, 齋藤 心, 佐田 尚宏, 安田 是和
    日本外科学会雑誌  2013/03  (一社)日本外科学会
  • 齋藤 心, 森嶋 計, 宇井 崇, 細谷 好則, 佐田 尚宏, 安田 是和
    日本外科学会雑誌  2013/03  (一社)日本外科学会
  • 笠原 尚哉, 寺谷 工, 前田 雅志, 土井 淳司, 佐田 尚宏, 安田 是和, 小林 英司
    日本外科学会雑誌  2013/03  (一社)日本外科学会
  • 清水 徹一郎, 堀江 久永, 細谷 好則, 佐田 尚宏, 安田 是和, 窓岩 清治, 大森 司, 三室 淳, 篠原 貴子, 丹羽 康則
    日本外科学会雑誌  2013/03  (一社)日本外科学会
  • SHIMOJI SHIN, SASANUMA HIDEKI, SAKAMOTO SAORI, KURASHINA KENTARO, SAKUMA YASUNARI, SATA NAOHIRO, YASUDA YOSHIKAZU
    日本腹部救急医学会雑誌  2013/02  日本腹部救急医学会
  • CHOUCHI KEN, SASANUMA HIDEKI, SAITO SHIN, IZAWA YOSHIMITSU, KOINUMA KOJI, SATA NAOHIRO, YASUDA YOSHIKAZU
    日本腹部救急医学会雑誌  2013/02  日本腹部救急医学会
  • KOIZUMI DAI, SATA NAOHIRO, TAGUCHI MASANOBU, KASAHARA NAOYA, KANEDA YUJI, ISHIGURO YASUNAO, ENDO KAZUHIRO, SASANUMA HIDEKI, SAKUMA YASUNARI, YASUDA YOSHIKAZU
    日本腹部救急医学会雑誌  2013/02  日本腹部救急医学会
  • AOKI YUICHI, KURASHINA KENTARO, TERAUCHI FUMIHITO, NAKAMURA YOSHIYASU, SASANUMA HIDEKI, SATA NAOHIRO, YASUDA YOSHIKAZU
    日本腹部救急医学会雑誌  2013/02  日本腹部救急医学会
  • KOIZUMI DAI, SATA NAOHIRO, TAGUCHI MASANOBU, KASAHARA NAOYA, KANEDA YUJI, ENDO KAZUHIRO, SASANUMA HIDEKI, SAKUMA YASUNARI, YASUDA YOSHIKAZU
    日本肝胆膵外科学会・学術集会プログラム・抄録集  2013
  • 目黒由行, 熊野秀俊, 俵藤正信, 堀江久永, 佐田尚宏, 安田是和
    日本臨床外科学会雑誌  2012/12
  • 低侵襲手術ナビゲーション最前線 Virtual 3D画像と臓器立体モデル virtual 3D modelとreal 3D model 治療支援と教育的活用の現状  [Not invited]
    遠藤 和洋, 佐田 尚宏, 笹沼 英紀, 佐久間 康成, 俵藤 正信, 安田 是和
    日本内視鏡外科学会雑誌  2012/12  (一社)日本内視鏡外科学会
  • 太田学, 佐久間康成, 笹沼英紀, 小泉大, 遠藤和洋, 石黒保直, 眞田幸弘, 佐田尚宏, 安田是和
    小切開・鏡視外科学会雑誌  2012/11
  • 塩澤幹雄, 栗原克巳, 佐田尚宏, 安田是和, 丹波嘉一郎
    日本臨床外科学会雑誌  2012/10
  • 眞田幸弘, 眞田幸弘, 佐久間康成, 遠藤和洋, 笹沼英紀, 清水敦, 佐田尚宏, 安田是和
    日本臨床外科学会雑誌  2012/10
  • 目黒由行, 遠藤和洋, 瑞木亨, 細谷好則, 佐田尚宏, 安田是和
    日本臨床外科学会雑誌  2012/10
  • 青木裕一, 佐久間康成, 安田是和, 佐田尚宏, 清水敦, 笹沼英紀, 遠藤和洋, 石黒保直, 眞田幸弘
    日本臨床外科学会雑誌  2012/10
  • 小松原利英, 鯉沼広治, 清水敦, 佐田尚宏, 安田是和
    日本臨床外科学会雑誌  2012/10
  • 清水敦, 菱川修司, 菱川修司, 佐久間康成, 俵藤正信, 堀江久永, 細谷好則, 穂積康夫, LEFOR Alan, LEFOR Alan, 佐田尚宏, 佐田尚宏, 安田是和
    日本臨床外科学会雑誌  2012/10
  • 小泉大, 佐田尚宏, 眞田幸弘, 田口昌延, 笠原尚哉, 遠藤和洋, 笹沼英紀, 佐久間康成, 清水敦, 安田是和
    日本臨床外科学会雑誌  2012/10
  • 太田学, 鯉沼広治, 宮倉安幸, 清水徹一郎, 森本光昭, 森嶋計, 堀江久永, 佐田尚宏, 安田是和
    日本臨床外科学会雑誌  2012/10
  • 乳癌胃転移の一例  [Not invited]
    倉科憲太郎, 細谷好則, 藤井博文, 瑞木亨, 宇井崇, 春田英律, 齋藤心, 佐田尚宏, 安田是和
    日本臨床外科学会雑誌  2012/10
  • 清水徹一郎, 窓岩清治, 大森司, 三室淳, 堀江久永, 細谷好則, 佐田尚宏, 安田是和
    日本臨床外科学会雑誌  2012/10
  • 笹沼英紀, 佐田尚宏, 小泉大, 田口昌延, 森嶋計, 笠原尚哉, 兼田裕司, 三木厚, 佐久間康成, 清水敦, 福嶋敬宜, 安田是和
    日本臨床外科学会雑誌  2012/10
  • 森和亮, 遠藤和洋, 田口昌延, 森嶋計, 兼田裕司, 小泉大, 笹沼英紀, 佐久間康成, 清水敦, 佐田尚宏, 安田是和
    日本臨床外科学会雑誌  2012/10
  • 曽我部将哉, 佐久間康成, 小松原利英, 清水徹一郎, 佐田尚宏, 安田是和
    日本臨床外科学会雑誌  2012/10
  • 顕微鏡的に多数の腫瘍結節を有する多発性肝血管筋脂肪腫の1例
    眞田 幸弘, 佐久間 康成, 遠藤 和洋, 笹沼 英紀, 清水 敦, 佐田 尚宏, 安田 是和
    日本臨床外科学会雑誌  2012/10  日本臨床外科学会
  • 外科医の教育 先端医療技術開発センターならびにシミュレーションセンターとのタイアップによる自治医科大学での外科医教育の取り組み
    清水 敦, 菱川 修司, 佐久間 康成, 俵藤 正信, 堀江 久永, 細谷 好則, 穂積 康夫, Lefor Alan, 佐田 尚宏, 安田 是和
    日本臨床外科学会雑誌  2012/10  日本臨床外科学会
  • 倉科憲太郎, 春田英律, 平嶋勇希, 瑞木亨, 宇井崇, 齋藤心, 横山卓, 松本志郎, 細谷好則, 佐田尚宏, 安田是和
    Gastroenterol Endosc  2012/09
  • 佐田尚宏, 小泉大, 笹沼英紀
    胆道  2012/08
  • 松山泰, 松山泰, 岡崎仁昭, 岸浩一郎, 坂東政司, 矢野晴美, 川上忠孝, 武藤弘行, 佐田尚宏
    医学教育  2012/07  (一社)日本医学教育学会
  • 岡崎仁昭, 佐田尚宏, 松原茂樹
    医学教育  2012/07
  • 岡崎仁昭, 佐田尚宏, 松原茂樹
    医学教育  2012/07
  • 間葉系幹細胞分泌因子を添加した分離膵島の新規輸送液の開発
    笠原 尚哉, 寺谷 工, 土井 淳司, 藤本 康弘, 上本 伸二, 佐田 尚宏, 安田 是和, 小林 英司
    日本消化器外科学会総会  2012/07  (一社)日本消化器外科学会
  • 胆道嚢胞性疾患の診断と外科治療 腫瘍性嚢胞ならびに鑑別を要する非腫瘍性嚢胞  [Not invited]
    清水 敦, 佐久間 康成, 笹沼 英紀, 遠藤 和洋, 田口 昌延, 森嶋 計, 俵藤 正信, 藤原 岳人, 佐田 尚宏, 安田 是和
    日本消化器外科学会総会  2012/07  (一社)日本消化器外科学会
  • 当院で行った80歳以上の高齢者に対する幽門輪温存膵頭十二指腸切除術12例の検討  [Not invited]
    田口 昌延, 佐田 尚宏, 兼田 裕司, 遠藤 和洋, 志村 国彦, 小泉 大, 笹沼 英紀, 佐久間 康成, 俵藤 正信, 安田 是和
    日本消化器外科学会総会  2012/07  (一社)日本消化器外科学会
  • 副膵管由来と考えられた膵管内乳頭粘液性腫瘍(IPMN)の一例  [Not invited]
    伊藤 誉, 高橋 大二郎, 笹沼 英紀, 佐久間 康成, 佐田 尚宏, 安田 是和, 今田 浩生, 福島 敬宜
    日本消化器外科学会総会  2012/07  (一社)日本消化器外科学会
  • 3次元可視化技術を用いた3D virtual model、3D real modelの臨床活用  [Not invited]
    遠藤 和洋, 佐田 尚宏, 田口 昌延, 笹沼 英紀, 佐久間 康成, 清水 敦, 俵藤 正信, 安田 是和
    日本消化器外科学会総会  2012/07  (一社)日本消化器外科学会
  • 当院における腹腔鏡下スリーブ状胃切除術の効果
    細谷 好則, 春田 英律, 佐田 尚宏, 安田 是和, 石橋 俊, 大須賀 淳一, 永島 秀一, 岡島 美朗, 佐藤 敏子, 竹内 譲, 布宮 伸, 多賀谷 信美, 川村 功
    日本肥満症治療学会学術集会プログラム・抄録集  2012/06  日本肥満症治療学会
  • 肥満症手術合併症とその対策 当院での腹腔鏡下スリーブ状胃切除の合併症対策
    細谷 好則, 春田 英律, 佐田 尚宏, 安田 是和, 石橋 俊, 竹内 護, 布宮 伸, 多賀谷 信美, 川村 功
    日本肥満症治療学会学術集会プログラム・抄録集  2012/06  日本肥満症治療学会
  • 上田純二, 田中雅夫, 大塚隆生, 下瀬川徹, 徳永正二, 江川新一, 神澤輝実, 木原康之, 伊藤鉄英, 入澤篤志, 久津見弘, 川茂幸, 中村光男, 植村正人, 安藤朗, 佐田尚宏, 峯徹哉, 羽鳥隆, 片岡慶正, 岡崎和一, 古屋智規, 伊佐地秀司, 山口武人
    すい臓  2012/05
  • 佐田尚宏, 田口昌延, 森嶋計, 眞田幸弘, 兼田裕司, 三木厚, 遠藤和洋, 小泉大, 笹沼英紀, 佐久間康成, 清水敦, 安田是和
    すい臓  2012/05
  • 笹沼英紀, 佐田尚宏, 小泉大, 田口昌延, 森嶋計, 笠原尚哉, 兼田裕司, 三木厚, 遠藤和洋, 佐久間康成, 清水敦, 福嶋敬宜, 安田是和
    すい臓  2012/05
  • 松本志郎, 佐田尚宏, 伊藤誉, 森本光昭, 遠藤和洋, 小泉大, 安田是和, 福嶋敬宜
    すい臓  2012/05
  • 兼田裕司, 佐田尚宏, 田口昌延, 笠原尚哉, 森嶋計, 遠藤和洋, 小泉大, 笹沼英紀, 佐久間康成, 清水敦, 俵藤正信, 安田是和
    すい臓  2012/05
  • 黒河内顕, 佐田尚宏, 遠藤和洋, 兼田裕司, 小泉大, 笹沼英紀, 安田和是
    すい臓  2012/05
  • 佐田 尚宏, 田口 昌延, 森嶋 計, 眞田 幸弘, 兼田 裕司, 三木 厚, 遠藤 和洋, 小泉 大, 笹沼 英紀, 佐久間 康成, 清水 敦, 安田 是和
    膵臓  2012/05  (一社)日本膵臓学会
  • 笹沼 英紀, 佐田 尚宏, 小泉 大, 田口 昌延, 森嶋 計, 笠原 尚哉, 兼田 裕司, 三木 厚, 遠藤 和洋, 佐久間 康成, 清水 敦, 福嶋 敬宜, 安田 是和
    膵臓  2012/05  (一社)日本膵臓学会
  • 中島賢憲, 安田一朗, 岩井知久, 伊佐山浩通, 糸井隆夫, 久居弘幸, 井上宏之, 加藤博也, 菅野敦, 窪田賢輔, 入澤篤志, 五十嵐久人, 岡部義信, 北野雅之, 河上洋, 林毅, 向井強, 木田光弘, 佐田尚宏, 下瀬川徹
    Gastroenterol Endosc  2012/04
  • 佐渡和也, 小泉大, 松本志郎, 細谷好則, 佐田尚宏, 安田是和
    日本臨床外科学会雑誌  2012/03
  • 佐田尚宏, 小泉大, 志村国彦, 兼田裕司, 笠原尚哉, 森嶋計, 田口昌延, 三木厚, 遠藤和洋, 藤原岳人, 清水敦, 俵藤正信, 安田是和
    日本外科学会雑誌  2012/03
  • 清水敦, 俵藤正信, 佐久間康成, 藤原岳人, 遠藤和洋, 三木厚, 笹沼英紀, 森嶋計, 田口昌延, 笠原尚哉, 小泉大, 兼田裕司, 山下圭輔, 佐田尚宏, 安田是和
    日本外科学会雑誌  2012/03  一般社団法人日本外科学会
  • 遠藤和洋, 佐田尚宏, 田口昌延, 兼田裕司, 三木厚, 小泉大, 笹沼英紀, 藤原岳人, 佐久間康成, 清水敦, 俵藤正信, 安田是和
    日本外科学会雑誌  2012/03  一般社団法人日本外科学会
  • 清水 敦, 俵藤 正信, 佐久間 康成, 藤原 岳人, 遠藤 和洋, 三木 厚, 笹沼 英紀, 森嶋 計, 田口 昌延, 笠原 尚哉, 小泉 大, 兼田 裕司, 山下 圭輔, 佐田 尚宏, 安田 是和
    日本外科学会雑誌  2012/03  (一社)日本外科学会
  • 遠藤 和洋, 佐田 尚宏, 田口 昌延, 兼田 裕司, 三木 厚, 小泉 大, 笹沼 英紀, 藤原 岳人, 佐久間 康成, 清水 敦, 俵藤 正信, 安田 是和
    日本外科学会雑誌  2012/03  (一社)日本外科学会
  • 腹腔鏡下胃全摘術の安全性と有効性 手術手技は完成されたか、患者さんに勧める根拠はあるのか OTG vs LATG
    瑞木 亨, 細谷 好則, 倉科 憲太郎, 春田 英律, 宇井 崇, 斎藤 心, 佐田 尚宏, 安田 是和
    日本胃癌学会総会記事  2012/02  (一社)日本胃癌学会
  • 瑞木亨, 細谷好則, 倉科憲太郎, 宇井崇, 春田英律, 齋藤心, 松本志郎, 佐田尚宏, 安田是和
    日本食道学会学術集会プログラム・抄録集  2012
  • 清水敦, 俵藤正信, 佐久間康成, 笹沼英紀, 藤原岳人, 遠藤和洋, 田口昌延, 眞田幸弘, 森嶋計, 笠原尚哉, 三木厚, 志村国彦, 兼田裕司, 佐田尚宏, 安田是和
    日本肝胆膵外科学会・学術集会プログラム・抄録集  2012
  • 兼田裕司, 佐田尚宏, 田口昌延, 笠原尚哉, 森嶋計, 遠藤和洋, 小泉大, 笹沼英紀, 佐久間康成, 清水敦, 俵藤正信, 安田是和
    日本肝胆膵外科学会・学術集会プログラム・抄録集  2012
  • 田口昌延, 俵藤正信, 森嶋計, 三木厚, 遠藤和洋, 兼田裕司, 小泉大, 藤原岳人, 清水敦, 佐田尚宏, 安田是和
    日本肝胆膵外科学会・学術集会プログラム・抄録集  2012
  • 胆管小細胞癌の1例  [Not invited]
    谷口理丈, 佐久間康成, 藤原岳人, 太田学, 安田寿彦, 佐田尚宏, 安田是和
    日本肝胆膵外科学会・学術集会プログラム・抄録集  2012
  • 前田浩史, 三木厚, 佐田友藍, 俵藤正信, 佐田尚宏, 安田是和
    日本臨床外科学会雑誌  2011/12
  • 腹腔鏡下胃切除後のRoux-en-Y再建では内ヘルニア対策が必要である
    宇井 崇, 細谷 好則, 春田 英律, 瑞木 亨, 斉藤 心, 倉科 憲太郎, 金丸 理人, Lefor Alan, 佐田 尚宏, 安田 是和
    日本内視鏡外科学会雑誌  2011/12  (一社)日本内視鏡外科学会
  • 当科での腹腔鏡下胃切除の合併症経験と対策
    細谷 好則, 瑞木 亨, 春田 英律, 倉科 憲太郎, 斉藤 心, 佐田 尚宏, 安田 是和
    日本内視鏡外科学会雑誌  2011/12  (一社)日本内視鏡外科学会
  • 肥満手術は日本で成功するのか 腹腔鏡下スリーブ状胃切除後の狭窄に対してLaparoscopic billiopancreatic diversionを施行した1例
    春田 英律, 細谷 好則, 川村 功, 石橋 俊, 瑞木 亨, 宇井 崇, 齋藤 心, 倉科 憲太郎, 佐田 尚宏, 安田 是和
    日本内視鏡外科学会雑誌  2011/12  (一社)日本内視鏡外科学会
  • 技術認定制度の目指すもの(トレーニングシステム) 自治医科大学消化器一般外科方式内視鏡外科トレーニングシステム
    佐田 尚宏, Lefor Alan, 兼田 裕司, 小泉 大, 宮倉 安幸, 堀江 久永, 俵藤 正信, 細谷 好則, 安田 是和
    日本内視鏡外科学会雑誌  2011/12  (一社)日本内視鏡外科学会
  • 胃癌に対するLATGとLAPGの比較検討  [Not invited]
    瑞木 亨, 細谷 好則, 春田 英律, 宇井 崇, 斎藤 心, 倉科 憲太郎, 段ノ上 秀雄, 中村 美鈴, 佐田 尚宏, 安田 是和
    日本内視鏡外科学会雑誌  2011/12  (一社)日本内視鏡外科学会
  • 遠藤和洋, 佐田尚宏, 安田是和
    小切開・鏡視外科学会雑誌  2011/11
  • 三木厚, 田口昌延, 笠原尚哉, 森嶋計, 兼田裕司, 小泉大, 藤原岳人, 佐久間康成, 太田真, 清水敦, 俵藤正信, 佐田尚宏, 安田是和
    日本臨床外科学会雑誌  2011/10
  • 金丸理人, 小泉大, 志村国彦, 笹沼英紀, 俵藤正信, 佐田尚宏, 安田是和
    日本臨床外科学会雑誌  2011/10
  • 遠藤和洋, 佐田尚宏, 田口昌延, 兼田裕司, 三木厚, 小泉大, 藤原岳人, 清水敦, 俵藤正信, 安田是和
    日本臨床外科学会雑誌  2011/10
  • 伊藤誉, 三木厚, 小泉大, 佐田尚宏, 安田是和, 山口岳彦, 坂谷貴司, 福島敬宜
    日本臨床外科学会雑誌  2011/10
  • 三木厚, 伊藤誉, 清水敦, 俵藤正信, 佐田尚宏, 安田是和
    日本臨床外科学会雑誌  2011/10
  • 佐田尚宏, 小泉大, 笠原尚哉, 兼田裕司, 遠藤和洋, 志村国彦, 笹沼英紀, 佐久間康成, 俵藤正信, 安田是和
    日本臨床外科学会雑誌  2011/10
  • 目黒由行, 細谷好則, 長瀬通隆, 瑞木亨, 福嶋敬宣, 藤井博文, 佐田尚宏, 安田是和
    日本臨床外科学会雑誌  2011/10
  • 清水徹一郎, 細谷好則, 兼田裕司, 瑞木亨, 佐田尚宏, 安田是和
    日本臨床外科学会雑誌  2011/10
  • 松本志郎, 小泉大, 新井悠介, 佐渡和也, 森本光昭, 佐田尚宏, 安田是和
    日本臨床外科学会雑誌  2011/10
  • 99Tc-GalactosylHuman Serum Albumin(GSA)シンチグラフィーを用いた術前肝予備能評価の有用性
    三木 厚, 田口 昌延, 笠原 尚哉, 森嶋 計, 兼田 裕司, 小泉 大, 藤原 岳人, 佐久間 康成, 太田 真, 清水 敦, 俵藤 正信, 佐田 尚宏, 安田 是和
    日本臨床外科学会雑誌  2011/10  日本臨床外科学会
  • 肝胆膵領域における手術シミュレーション 3D-virtualおよび3D-real modelによる肝胆膵手術simulationおよびnavigationの試み
    遠藤 和洋, 佐田 尚宏, 田口 昌延, 兼田 裕司, 三木 厚, 小泉 大, 藤原 岳人, 清水 敦, 俵藤 正信, 安田 是和
    日本臨床外科学会雑誌  2011/10  日本臨床外科学会
  • 当科における幽門輪温存膵頭十二指腸の前壁切開膵胃吻合法の工夫
    佐田 尚宏, 小泉 大, 笠原 尚哉, 兼田 裕司, 遠藤 和洋, 志村 国彦, 笹沼 英紀, 佐久間 康成, 俵藤 正信, 安田 是和
    日本臨床外科学会雑誌  2011/10  日本臨床外科学会
  • 笠原尚哉, 笠原尚哉, 寺谷工, 藤本康弘, 佐田尚宏, 安田是和, 上本伸二, 小林英司
    移植  2011/10
  • 春田英律, 細谷好則, 宇井崇, 瑞木亨, 倉科憲太郎, 帖地健, 矢野智則, 山本博徳, 菅野健太郎, 佐田尚宏, 安田是和
    Gastroenterol Endosc  2011/09
  • 春田英律, 細谷好則, 宇井崇, 瑞木亨, 齋藤心, 石橋俊, 竹内譲, 佐田尚宏, 安田是和, 矢田俊彦
    肥満研究  2011/09
  • 細谷好則, 春田英律, 佐田尚宏, 安田是和, 石橋俊, 岡島美朗, 竹内譲, 布宮紳, 佐藤敏子, 多賀谷信美, 川村功, 矢田俊彦
    肥満研究  2011/09
  • 瑞木亨, 細谷好則, 俵藤正信, 宇井崇, 佐久間康成, 春田英律, 佐田尚宏, 安田是和
    日本門脈圧こう進症学会雑誌  2011/08
  • 兼田裕司, 小泉大, 笠原尚哉, 森嶋計, 藤原岳人, 清水敦, 俵藤正信, 佐田尚宏, 安田是和
    胆道  2011/08
  • 胃静脈瘤の分類と私の治療手技 当科における腹腔鏡下胃静脈瘤手術
    瑞木 亨, 細谷 好則, 俵藤 正信, 宇井 崇, 佐久間 康成, 春田 英律, 佐田 尚宏, 安田 是和
    日本門脈圧亢進症学会雑誌  2011/08  (一社)日本門脈圧亢進症学会
  • 兼田 裕司, 小泉 大, 笠原 尚哉, 森嶋 計, 藤原 岳人, 清水 敦, 俵藤 正信, 佐田 尚宏, 安田 是和
    胆道  2011/08  日本胆道学会
  • 自治医科大学におけるマルチメディアadvanced CBT形式の記述式(SEQ)総合判定試験の導入
    松山 泰, 岡崎 仁昭, 岸 浩一郎, 河野 正樹, 金井 信行, 黒木 茂広, 坂東 政司, 矢野 晴美, 川上 忠孝, 武藤 弘行, 佐田 尚宏
    医学教育  2011/07  (一社)日本医学教育学会
  • 二期的手術が奏功したクローン病による結腸十二指腸瘻の1例
    瑞木 亨, 目黒 由行, 熊野 秀俊, 宮倉 安幸, 堀江 久永, 佐田 尚宏, 安田 是和
    日本消化器外科学会総会  2011/07  (一社)日本消化器外科学会
  • 当院の膵癌切除症例の治療成績と予後因子についての検討
    兼田 裕司, 佐田 尚宏, 小泉 大, 笠原 尚哉, 森嶋 計, 藤原 岳人, 太田 真, 俵藤 正信, 安田 是和
    日本消化器外科学会総会  2011/07  (一社)日本消化器外科学会
  • 十二指腸乳頭部癌に対する経十二指腸的・経腹腔的乳頭切除術
    小泉 大, 佐田 尚宏, 笠原 尚哉, 森嶋 計, 兼田 裕司, 藤原 岳人, 太田 真, 俵藤 正信, 安田 是和
    日本消化器外科学会総会  2011/07  (一社)日本消化器外科学会
  • Rapid Prototyping法を用いた、術前MD-CT画像からの臓器立体モデル作成と手術支援システム  [Not invited]
    遠藤 和洋, 佐田 尚宏, 小泉 大, 笹沼 英紀, 俵藤 正信, 安田 是和
    日本消化器外科学会総会  2011/07  (一社)日本消化器外科学会
  • 肉腫様成分を認めた肝癌4例の検討  [Not invited]
    森嶋 計, 俵藤 正信, 小泉 大, 藤原 岳人, 佐久間 康成, 太田 真, 清水 敦, 福嶋 敬宜, 佐田 尚宏, 安田 是和
    日本消化器外科学会総会  2011/07  (一社)日本消化器外科学会
  • 相良裕一, 春田英律, 細谷好則, 久保田仁守, 瑞木亨, 宇井崇, 倉科憲太郎, 斎藤心, 佐田尚宏, 安田是和
    日本臨床外科学会雑誌  2011/06
  • 小泉大, 佐田尚宏, 笠原尚哉, 森嶋計, 兼田裕司, 藤原岳人, 太田真, 俵藤正信, 安田是和
    すい臓  2011/06
  • 減量手術の周術期管理 当院における腹腔鏡下スリーブ状胃切除術の周術期管理
    細谷 好則, 春田 英律, 佐田 尚宏, 安田 是和, 石橋 俊, 岡島 美朗, 佐藤 敏子, 竹内 譲, 布宮 伸, 多賀谷 信美, 川村 功
    日本肥満症治療学会学術集会プログラム・抄録集  2011/06  日本肥満症治療学会
  • IPMNの術式とその根拠(2) 膵IPMNの術式選択における残膵切除術・膵全摘術の検討
    小泉 大, 佐田 尚宏, 笠原 尚哉, 森嶋 計, 兼田 裕司, 藤原 岳人, 太田 真, 俵藤 正信, 安田 是和
    日本肝胆膵外科学会・学術集会プログラム・抄録集  2011/06  (一社)日本肝胆膵外科学会
  • 三木厚, 小泉大, 笠原尚哉, 兼田祐司, 藤原岳人, 佐久間康成, 太田真, 俵藤正信, 佐田尚宏, 安田是和
    日本外科学会雑誌  2011/05
  • 笠原尚哉, 寺谷工, 根岸幸司, 岩崎純治, 金澤寛之, 上本伸二, 佐田尚宏, 藤本康弘, 小林英司
    日本外科学会雑誌  2011/05
  • 遠藤和洋, 佐田尚宏, 吉川貴久, 木全大, 古川潤二, 篠崎浩治, 加瀬建一, 小林健二, 尾形佳郎, 安田是和
    日本外科学会雑誌  2011/05
  • 小泉大, 佐田尚宏, 笠原尚哉, 森嶋計, 兼田裕司, 笹沼英紀, 藤原岳人, 太田真, 俵藤正信, 安田是和
    日本外科学会雑誌  2011/05
  • 兼田裕司, 小泉大, 笠原尚哉, 森嶋計, 笹沼英紀, 藤原岳人, 太田真, 俵藤正信, 佐田尚宏, 安田是和
    日本外科学会雑誌  2011/05  一般社団法人日本外科学会
  • 森美鈴, 小泉大, 佐田尚宏, 安田是和
    日本外科学会雑誌  2011/05
  • 横田真一郎, 小泉大, 富樫一智, LEFOR Alan T, 堀江久永, 細谷好則, 佐田尚宏, 安田是和
    日本外科学会雑誌  2011/05
  • 森嶋計, 佐田尚宏, 横田真一郎, 笠原尚哉, 志村国彦, 小泉大, 藤原岳人, 佐久間康成, 太田真, 清水敦, 俵藤正信, 喜舎場由香, 福嶋敬宜, 安田是和
    日本臨床外科学会雑誌  2011/04
  • 当院での胃癌に対する腹腔鏡補助下胃切除術の治療成績
    宇井 崇, 細谷 好則, 瑞木 亨, 春田 英律, 倉科 憲太郎, 佐田 尚宏, 安田 是和
    日本胃癌学会総会記事  2011/03  (一社)日本胃癌学会
  • NET(ケース) 神経内分泌腫瘍の経過中にソマトスタチンレセプターシンチグラフィを施行した3症例
    笠原 尚哉, 細谷 好則, 倉科 憲太郎, 瑞木 亨, 佐田 尚宏, 安田 是和
    日本胃癌学会総会記事  2011/03  (一社)日本胃癌学会
  • 森本光昭, 俵藤正信, 細谷好則, 堀江久永, 熊野秀俊, 井上賢之, 宮倉安幸, 佐田尚宏, 安田是和
    日本腹部救急医学会雑誌  2011/02
  • 森美鈴, 兼田裕司, 小泉大, 堀江久永, 俵藤正信, 岡田真樹, 佐田尚宏, 安田是和
    日本腹部救急医学会雑誌  2011/02
  • 帖地健, 三木厚, 佐田友藍, 宮倉安幸, 佐田尚宏, 安田是和
    日本腹部救急医学会雑誌  2011/02
  • 目黒由行, 小泉大, 宇井崇, 俵藤正信, 佐田尚宏, 安田是和
    日本腹部救急医学会雑誌  2011/02
  • 佐久間康成, 堀江久永, 宮倉安幸, 鯉沼広冶, 熊野秀俊, 佐田尚宏, 安田是和
    日本腹部救急医学会雑誌  2011/02
  • 阿藤一志, 佐久間康成, 熊野秀俊, 宮倉安幸, 堀江久永, 佐田尚宏, 安田是和, 中田学
    日本腹部救急医学会雑誌  2011/02
  • 勝部乙大, 細谷好則, 齋藤心, 倉科憲太郎, 春田英律, 宇井崇, 瑞木亨, 佐田尚宏, 安田是和, 山口岳彦
    日本食道学会学術集会プログラム・抄録集  2011
  • 春田英律, 細谷好則, 相良裕一, 宇井崇, 倉科憲太郎, 瑞木亨, 西野宏, 須永中, 佐田尚宏, 安田是和
    日本食道学会学術集会プログラム・抄録集  2011
  • 小泉大, 佐田尚宏, 笠原尚哉, 森嶋計, 兼田裕司, 藤原岳人, 太田真, 俵藤正信, 安田是和
    日本肝胆膵外科学会・学術集会プログラム・抄録集  2011
  • 兼田裕司, 小泉大, 笠原尚哉, 森嶋計, 藤原岳人, 太田真, 俵藤正信, 佐田尚宏, 安田是和
    日本肝胆膵外科学会・学術集会プログラム・抄録集  2011
  • 清水敦, 志村国彦, 俵藤正信, 佐久間康成, 笹沼英紀, 森嶋計, 太田真, 藤原岳人, 山下圭輔, 佐田尚宏, 安田是和
    日本肝胆膵外科学会・学術集会プログラム・抄録集  2011
  • 森嶋計, 俵藤正信, 志村国彦, 小泉大, 仁平芳人, 藤原岳人, 佐久間康成, 太田真, 清水敦, 佐田尚宏, 安田是和
    日本肝胆膵外科学会・学術集会プログラム・抄録集  2011
  • 目黒由行, 小泉大, 笠原尚哉, 俵藤正信, 佐田尚宏, 安田是和
    日本肝胆膵外科学会・学術集会プログラム・抄録集  2011
  • 俵藤正信, 長瀬通隆, 堀江久永, 笹沼英紀, 藤原岳人, 佐久間康成, 太田真, 清水敦, 熊野秀俊, 宮倉安幸, 佐田尚宏, 藤井博文, 安田是和
    日本肝胆膵外科学会・学術集会プログラム・抄録集  2011
  • 細谷好則, 春田英律, 佐田尚宏, 安田是和, 石橋俊, 岡島美朗, 佐藤敏子, 竹内譲, 布宮伸, 多賀谷信美, 川村功
    日本肥満症治療学会学術集会プログラム・抄録集  2011
  • 三木厚, 佐久間康成, 兼田祐司, 小泉大, 藤原岳人, 俵藤正信, 佐田尚宏, 安田是和
    日本肝胆膵外科学会・学術集会プログラム・抄録集  2011
  • 小泉大, 佐田尚宏, 笠原尚哉, 森嶋計, 兼田裕司, 志村国彦, 笹沼英紀, 藤原岳人, 太田真, 俵藤正信, 山下圭輔, 安田是和
    日本臨床外科学会雑誌  2010/10
  • 森美鈴, 小泉大, 兼田裕司, 熊野秀俊, 宮倉安幸, 堀江久永, 佐田尚宏, 安田是和
    日本臨床外科学会雑誌  2010/10
  • 俵藤正信, 藤原岳人, 太田真, 小泉大, 森嶋計, 志村国彦, 仁平芳人, 北條宣幸, 清水敦, 佐久間康成, 佐田尚宏, 安田是和
    日本臨床外科学会雑誌  2010/10
  • 清水敦, 俵藤正信, 佐久間康成, 笹沼英紀, 森嶋計, 太田真, 志村国彦, 藤原岳人, 小泉大, 山下圭介, 佐田尚宏, 安田是和
    日本臨床外科学会雑誌  2010/10
  • 黒河内顕, 俵藤正信, 佐田友藍, 佐田尚宏, 安田是和
    日本臨床外科学会雑誌  2010/10
  • 森嶋計, 宇井崇, 春田英律, 倉科憲太郎, 斉藤心, 荒井渉, 瑞木亨, 俵藤正信, 佐田尚宏, 長瀬道隆, 藤井博之, 安田是和
    日本臨床外科学会雑誌  2010/10
  • 阿藤一志, 佐久間康成, 熊野秀俊, 宮倉安幸, 堀江久永, 佐田尚宏, 安田是和, 仲澤聖則
    日本臨床外科学会雑誌  2010/10
  • 重症筋無力症患者の胃癌に対して腹腔鏡下噴門側胃切除術を施行した一例
    宇井 崇, 細谷 好則, 倉科 憲太郎, 春田 英律, 佐藤 正章, 瀬尾 憲正, Lefor Alan, 佐田 尚宏, 安田 是和
    日本内視鏡外科学会雑誌  2010/10  (一社)日本内視鏡外科学会
  • GISTと鑑別困難だった胃粘膜下腫瘍を胃内手術により切除した1例
    瑞木 亨, 細谷 好則, 斎藤 心, 倉科 憲太郎, 春田 英律, 宇井 崇, 佐田 尚宏, 安田 是和
    日本内視鏡外科学会雑誌  2010/10  (一社)日本内視鏡外科学会
  • 当科での段階的な鏡視下手術トレーニングの運用
    小泉 大, 佐田 尚宏, Lefor Alan, 宮倉 安幸, 堀江 久永, 俵藤 正信, 細谷 好則, 安田 是和
    日本内視鏡外科学会雑誌  2010/10  (一社)日本内視鏡外科学会
  • FDG-PETで中等度集積を認め胸腔鏡下切除した食道神経鞘腫の1例
    阿藤 一志, 勝部 乙大, 太田 真, 倉科 憲太郎, 細谷 好則, 佐田 尚宏, 安田 是和, 松原 大祐, 田中 亨
    日本内視鏡外科学会雑誌  2010/10  (一社)日本内視鏡外科学会
  • 成人再発鼠径ヘルニアに対する腹腔鏡観察併用Lichtenstein法の有用性について  [Not invited]
    齋藤 心, 小泉 大, 太田 真, 笹沼 英紀, 佐田 尚宏, 安田 是和
    日本内視鏡外科学会雑誌  2010/10  (一社)日本内視鏡外科学会
  • 腹腔鏡下噴門側胃切除におけるDouble tract法再建  [Not invited]
    細谷 好則, 宇井 宗, 春田 英律, 倉科 憲太郎, 瑞木 亨, 中村 美鈴, Lefor Alan, 佐田 尚宏, 安田 是和
    日本内視鏡外科学会雑誌  2010/10  (一社)日本内視鏡外科学会
  • 長瀬通隆, 金丸理人, 小泉大, 志村国彦, 藤原岳人, 佐久間康成, 清水敦, 俵藤正信, 佐田尚宏, 上田真寿, 藤井博文, 安田是和
    日本癌治療学会誌  2010/09
  • 牛尾純, 玉田喜一, 矢野智則, 畑中恒, 大橋明, 和田伸一, 阿藤一志, 志村国彦, 佐田尚宏, 弘中貢, 福嶋敬宜, 菅野健太郎
    日本消化器病学会雑誌  2010/09
  • 勝部乙大, 齋藤心, 細谷好則, 倉科憲太郎, 宇井崇, 春田英律, 佐田尚宏, 安田是和, 仁木利郎
    日本消化器病学会雑誌  2010/09
  • 大木準, 濱田徹, 佐田尚宏
    小切開・鏡視外科学会雑誌  2010/09
  • 高澤一平, 倉科憲太郎, 森和亮, 小泉大, 金丸理人, 関口忠司, 佐田尚宏
    小切開・鏡視外科学会雑誌  2010/09
  • 宇井崇, 細谷好則, 春田英律, 瑞木亨, 倉科憲太郎, 斉藤心, 俵藤正信, LEFOR Alan, 佐田尚宏, 安田是和
    小切開・鏡視外科学会雑誌  2010/09
  • 細谷好則, 堀江久永, 春田英律, 倉科憲太郎, 宮倉安幸, 宇井宗, 熊野秀俊, 佐田尚宏, 安田是和
    小切開・鏡視外科学会雑誌  2010/09
  • 小泉大, 佐田尚宏, 熊野秀俊, LEFOR Alan, 宮倉安幸, 堀江久永, 俵藤正信, 細谷好則, 安田是和
    小切開・鏡視外科学会雑誌  2010/09
  • 宇井崇, 佐久間康成, 細谷好則, 藤原岳人, 俵藤正信, 笠原尚哉, 太田学, 太田真, 佐田尚宏, 安田是和
    日本門脈圧こう進症学会雑誌  2010/08
  • 食道損傷の治療 胸部下行大動脈破裂に伴う食道穿孔の3例
    細谷 好則, 藤原 岳人, 瑞木 亨, 小西 宏明, 大木 伸一, 上西 祐一郎, 佐田 尚宏, 安田 是和
    日本食道学会学術集会プログラム・抄録集  2010/08  (NPO)日本食道学会
  • KOIZUMI MASARU, SAKUMA YASUNARU, MORI MISUZU, UI TAKASHI, SATA NAOHIRO, YASUDA YOSHIKAZU
    日本臨床外科学会雑誌  2010/07
  • 堀江健司, 志村国彦, 笠原尚哉, 森嶋計, 藤原岳人, 佐久間康成, 清水敦, 太田真, 佐田尚宏
    日本臨床外科学会雑誌  2010/07
  • 食道切除後の血管吻合付加を伴うRoux-en Y型空腸再建手術
    齋藤 心, 細谷 好則, 倉科 憲太郎, 宇井 崇, 春田 英律, 瑞木 亨, 上田 和毅, 去川 俊二, 佐田 尚宏, 安田 是和
    日本消化器外科学会総会  2010/07  (一社)日本消化器外科学会
  • MRI造影剤リゾビストを用いたセンチネルリンパ節生検(ブタ胃を用いた動物実験)
    塩澤 幹雄, 佐田 尚宏, 細谷 好則, Lefor Alan, 安田 是和
    日本消化器外科学会総会  2010/07  (一社)日本消化器外科学会
  • 術中超音波で静脈瘤の血流モニタリングを行い腹腔鏡下に血行郭清術を施行した3例
    佐久間 康成, 細谷 好則, 太田 真, 清水 敦, 志村 国彦, 笠原 尚哉, 藤原 岳人, 佐田 尚宏, 安田 是和
    日本消化器外科学会総会  2010/07  (一社)日本消化器外科学会
  • 胃癌肝転移に対する肝切除症例の検討  [Not invited]
    森嶋 計, 細谷 好則, 倉科 憲太郎, 笹沼 英紀, 瑞木 亨, 俵藤 正信, 長瀬 道隆, 藤井 博文, 佐田 尚宏, 安田 是和
    日本消化器外科学会総会  2010/07  (一社)日本消化器外科学会
  • 高橋大二郎, 細谷好則, 三澤俊一, 熊野秀俊, 藤原岳人, 倉科憲太郎, 宇井崇, 佐田尚宏, 宮崎邦夫, 去川俊二, 中元明裕, 長瀬通隆, 藤井博文, 弘仲貢, 安田是和
    日本臨床外科学会雑誌  2010/04
  • 三澤知子, 畑中恒, 牛尾純, 大橋明, 和田伸一, 玉田喜一, 菅野健太郎, 志村国彦, 太田真, 佐田尚宏, 安田是和, 河田浩敏, 山口岳彦, 川井俊郎, 福嶋敬宜
    Gastroenterol Endosc  2010/04
  • 齋藤心, 細谷好則, 倉科憲太郎, 春田英律, 宇井崇, 俵藤正信, 森嶋計, 佐田尚宏, 仁木利朗, 安田是和
    日本外科学会雑誌  2010/03
  • 森嶋計, 斎藤心, 志村国彦, 小泉大, 藤原岳人, 佐久間康成, 清水敦, 俵藤正信, 仁木利郎, 佐田尚宏, 安田是和
    日本外科学会雑誌  2010/03
  • 三木厚, RICORDI Camillo, 佐久間康成, BARKER Scott, 三澤良介, 佐田尚宏, 安田是和, 市井啓仁
    日本外科学会雑誌  2010/03
  • 進行胃癌と傍大動脈濾胞リンパ腫を合併した一例
    笠原 尚哉, 細谷 好則, 瑞木 亨, 斎藤 心, 倉科 憲太郎, 宇井 崇, 春田 英律, 山口 岳彦, 仁木 利郎, 川井 俊郎, 佐田 尚宏, 安田 是和
    日本胃癌学会総会記事  2010/03  (一社)日本胃癌学会
  • 倉科憲太郎, 細谷好則, 長瀬通隆, 宇井崇, 春日英律, 藤井博文, 仁木利郎, 弘中貢, 佐田尚宏, 安田是和
    日本食道学会学術集会プログラム・抄録集  2010
  • 細谷好則, 藤原岳人, 瑞木亨, 小西宏明, 大木伸一, 上西祐一郎, 佐田尚宏, 安田是和
    日本食道学会学術集会プログラム・抄録集  2010
  • 三木厚, 佐久間康成, 藤原岳人, 石川暢夫, 八木沢隆, 佐田尚宏, 安田是和
    日本臨床腎移植学会プログラム・抄録集  2010
  • 佐久間康成, 細谷好則, 笠原尚哉, 森嶋計, 藤原岳人, 太田真, 清水敦, 俵藤正信, 佐田尚宏, 安田是和
    日本肝胆膵外科学会・学術集会プログラム・抄録集  2010
  • 森嶋計, 笠原尚哉, 小泉大, 鯉沼広治, 仁平芳人, 佐久間康成, 俵藤正信, 佐田尚宏, 安田是和
    日本肝胆膵外科学会・学術集会プログラム・抄録集  2010
  • 清水敦, 森嶋計, 佐久間康成, 藤原岳人, 太田真, 志村国彦, 笠原尚哉, 俵藤正信, 仁平芳人, 小泉大, 山下圭輔, 佐田尚宏, 川井俊郎, 福嶋敬宜, 服部照夫, 安田是和
    日本肝胆膵外科学会・学術集会プログラム・抄録集  2010
  • 岩下ちひろ, 瑞木亨, 佐田尚宏, 笹沼英紀, 佐久間康成, 清水敦, 俵藤正信, 安田是和
    日本臨床外科学会雑誌  2009/12
  • 腹腔鏡補助下幽門側胃切除術における吊り上げ法と気腹法の比較検討
    宇井 崇, 細谷 好則, 倉科 憲太郎, 斉藤 心, 春田 英律, 瑞木 亨, 俵藤 正信, 佐田 尚宏, Lefor Alan, 安田 是和
    日本内視鏡外科学会雑誌  2009/12  (一社)日本内視鏡外科学会
  • 腹腔鏡下に胃全摘と回盲部切除術を同時に施行した胃癌・結腸癌の一例
    巷野 佳彦, 細谷 好則, 堀江 久永, 宮倉 安幸, 熊野 秀俊, 倉科 憲太郎, 宇井 崇, 佐田 尚宏, 安田 是和
    日本内視鏡外科学会雑誌  2009/12  (一社)日本内視鏡外科学会
  • 腹腔鏡下手術を施行した下部食道憩室を伴う食道アカラシアの1例
    瑞木 亨, 細谷 好則, 倉科 憲太郎, 俵藤 正信, 佐田 尚宏, 安田 是和
    日本内視鏡外科学会雑誌  2009/12  (一社)日本内視鏡外科学会
  • 腹腔鏡下噴門側胃切除におけるTilt Top Plus-DST EEAを用いたDouble tract法再建
    細谷 好則, 宇井 崇, 倉科 憲太郎, 瑞木 亨, 佐田 尚宏, Lefor Alan, 安田 是和
    日本内視鏡外科学会雑誌  2009/12  (一社)日本内視鏡外科学会
  • 当科における腹腔鏡下胃全摘術のRoux en Y再建におけるStapling deviceの選択と使用法
    倉科 憲太郎, 細谷 好則, 瑞木 亨, 宇井 崇, 佐田 尚宏, Lefor Alan, 安田 是和
    日本内視鏡外科学会雑誌  2009/12  (一社)日本内視鏡外科学会
  • 田口昌延, 根本怜, 森美鈴, 笹沼英紀, 佐田尚宏, 安田是和
    日本臨床外科学会雑誌  2009/10
  • 佐田尚宏, 倉科憲太郎, LEFOR Alan, 菱川修司, 佐久間康成, 藤原岳人, 俵藤正信, 安田是和
    日本臨床外科学会雑誌  2009/10
  • 阿藤一志, 宇井崇, 佐久間康成, 堀江久永, 宮倉安幸, 熊野秀俊, 佐田尚宏, 安田是和
    日本臨床外科学会雑誌  2009/10
  • 小泉大, 佐田尚宏, 笠原尚哉, 森嶋計, 志村国彦, 笹沼英紀, 藤原岳人, 佐久間康成, 太田真, 清水敦, 俵藤正信, 山下圭輔, 安田是和
    日本臨床外科学会雑誌  2009/10
  • 栗田真紀子, 小泉大, 佐田尚宏, 安田是和
    日本臨床外科学会雑誌  2009/10
  • 村山瑛, 細谷好則, 田中宏幸, 清水敦, 佐田尚宏, 仁木利郎, 櫻井信司, 藤井博文, 安田是和
    日本臨床外科学会雑誌  2009/10
  • 横田真一郎, 小泉大, 佐田尚宏, 安田是和
    日本臨床外科学会雑誌  2009/10
  • 森嶋計, 細谷好則, 端木亨, 斎藤心, 俵藤正信, 佐田尚宏, 安田是和, 去川俊二
    日本臨床外科学会雑誌  2009/09
  • 小泉大, 佐田尚宏, 笠原尚哉, 森嶋計, 笹沼英紀, 佐久間康成, 清水敦, 俵藤正信, 山下圭輔, 安田是和
    日本消化器病学会雑誌  2009/09
  • 下咽頭癌手術後の胸部食道癌に対して食道全摘、遊離空腸遠位-胃管吻合再建を施行した一例
    森嶋 計, 細谷 好則, 端木 亨, 斎藤 心, 俵藤 正信, 佐田 尚宏, 安田 是和, 去川 俊二
    日本臨床外科学会雑誌  2009/09  日本臨床外科学会
  • 遠藤和洋, 佐田尚宏, 安田是和
    胆道  2009/08
  • 黒河内顕, 細谷好則, 小泉大, 俵藤正信, 佐田尚宏, 安田是和, 永井秀雄, 喜舎場由香
    日本臨床外科学会雑誌  2009/08
  • 巨大膵MCNの1切除例  [Not invited]
    宮本諭, 小泉大, 河野通彦, 斉藤心, 佐田尚宏, 安田是和
    日本臨床外科学会雑誌  2009/08
  • 仁平芳人, 金澤恵理, 北條彰, 栗田真紀子, 森嶋計, 笹沼英紀, 清水敦, 俵藤正信, 山下圭輔, 穂積康夫, 佐田尚宏, 安田是和
    日本臨床外科学会雑誌  2009/07
  • 佐久間康成, 田中宏幸, 宮倉安幸, 鯉沼広治, 堀江久永, 俵藤正信, 佐田尚宏, 安田是和
    日本消化器外科学会雑誌  2009/07
  • 清水敦, 田中宏幸, 瑞木亨, 佐久間康成, 清水徹一郎, 倉科憲太郎, 石黒保直, 山下圭輔, 佐田尚宏, 安田是和
    日本消化器外科学会雑誌  2009/07
  • 瑞木亨, 佐田尚宏, 笹沼英紀, 佐久間康成, 清水敦, 俵藤正信, 安田是和
    日本消化器外科学会雑誌  2009/07
  • 小泉大, 佐田尚宏, 笠原尚哉, 森嶋計, 笹沼英紀, 佐久間康成, 清水敦, 俵藤正信, 山下圭輔, 安田是和
    日本消化器外科学会雑誌  2009/07  一般社団法人日本消化器外科学会
  • 遠藤和洋, 佐田尚宏, 森嶋計, 笠原尚哉, 小泉大, 笹沼英紀, 佐久間康成, 清水敦, 俵藤正信, 安田是和
    すい臓  2009/06
  • 井上賢之, 小泉大, 笠原尚哉, 森島計, 笹沼英紀, 佐久間康成, 清水敦, 俵藤正信, 山下圭輔, 佐田尚宏, 安田是和
    すい臓  2009/06
  • 細谷 好則, Lefor Alan, 倉科 憲太郎, 瑞木 亨, 佐田 尚宏, 安田 是和
    日本消化器外科学会雑誌  2009/06  (一社)日本消化器外科学会
  • 食道癌術後に発症した後天性血友病Aの1例
    松村 美穂, 細谷 好則, 瑞木 亨, 倉科 憲太郎, 春田 英律, 齋藤 心, 佐田 尚宏, 安田 是和
    日本食道学会学術集会プログラム・抄録集  2009/06  (NPO)日本食道学会
  • 肝内胆管癌との鑑別が困難であった胆管炎、胆管周囲炎の1切除例
    田口 昌延, 俵藤 正信, 笹沼 英紀, 森嶋 計, 遠藤 和洋, 佐久間 康成, 清水 敦, 佐田 尚宏, 安田 是和
    日本肝胆膵外科学会・学術集会プログラム・抄録集  2009/06  (一社)日本肝胆膵外科学会
  • 細谷好則, ALAN Lefor, 倉科憲太郎, 瑞木亨, 佐田尚宏, 安田是和
    日本消化器外科学会雑誌  2009/06
  • 清水敦, 俵藤正信, 佐久間康成, 笹沼英紀, 森嶋計, 佐田尚宏, 安田是和
    肝臓  2009/04
  • 佐田尚宏
    日本消化器病学会雑誌  2009/03
  • 畑中恒, 玉田喜一, 細谷好則, 佐田尚宏, 安田是和, 菅野健太郎, 間野博行
    日本消化器病学会雑誌  2009/03
  • 益子尚子, 細谷好則, 小松健司, 齊藤心, 宗近次郎, 鯉沼広治, 長瀬通隆, 佐田尚宏, 安田是和, 川井俊郎
    日本臨床外科学会雑誌  2009/02  日本臨床外科学会
  • 清水敦, 俵藤正信, 佐久間康成, 笹沼英紀, 仁平芳人, 森嶋計, 山下圭輔, 小泉大, 笠原尚哉, 鯉沼広治, 宮倉安幸, 堀江久永, 長瀬通隆, 藤井博文, 佐田尚宏, 安田是和
    日本外科学会雑誌  2009/02  一般社団法人日本外科学会
  • 佐久間康成, RICORDI Camillo, 森嶋計, 俵藤正信, 清水敦, 笹沼英紀, 佐田尚宏, 安田是和, 矢田俊彦, 市井啓仁
    日本外科学会雑誌  2009/02  一般社団法人日本外科学会
  • 俵藤正信, 藤原岳人, 佐久間康成, 森嶋計, 笹沼英紀, 清水敦, 佐田尚宏, 眞田幸弘, 林田真, 江上聡, 菱川修司, 水田耕一, 河原崎秀雄, 安田是和
    日本外科学会雑誌  2009/02  一般社団法人日本外科学会
  • 外科手術の教育消化器, 小児外科, 呼吸器外科 (腹 胸腔鏡, 開腹 胸) 当院における外科手術トレーニング 縫合結紮から鏡視下手術トレーニングまで
    佐田尚宏
    日臨外会誌  2009
  • 石黒保直, 佐久間康成, 笹沼英紀, 森嶋計, 遠藤和洋, 清水敦, 俵藤正信, 佐田尚宏, 安田是和
    日本肝胆膵外科学会・学術集会プログラム・抄録集  2009
  • 清水敦, 俵藤正信, 佐久間康成, 笹沼英紀, 森嶋計, 遠藤和洋, 佐田尚宏, 松原大祐, 山口岳彦, 仁木利郎, 安田是和
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  • 小泉大, 佐田尚宏, 伊東一博, 富樫一智, 安田寿彦, 永井秀雄
    日本成人病学会会誌  2002
  • 斎藤心, 荒井渉, 俵藤正信, 佐田尚宏, 堀江久永, 永井秀雄, 桜井信司, 森永正二朗, 斎藤建
    日本臨床外科学会雑誌  2001/12
  • 吉沢浩次, 佐田尚宏, 永井秀雄
    日本消化器外科学会雑誌  2001/07
  • 佐田尚宏, 塚原宗俊, 吉沢浩次, 佐久間康成, 俵藤正信, 栗原克己, 大木準, 近藤泰雄, 永井秀雄
    日本消化器外科学会雑誌  2001/07
  • 佐田尚宏, 塚原宗俊, 吉沢浩次, 佐久間康成, 俵藤正信, 栗原克己, 大木準, 近藤泰雄, 永井秀雄
    すい臓  2001/06
  • 倉科憲太郎, 佐田尚宏, 細谷好則, 永井秀雄
    日本臨床外科学会雑誌  2001/04
  • 吉沢充代, 石野祐三子, 佐藤貴一, 飯野聡, 菅野健太郎, 佐田尚宏, 永井秀雄, 染谷勉, 斉藤建
    Gastroenterol Endosc  2001/03
  • 吉沢浩次, 桜井信司, 弘中貢, 森永正二郎, 栗原克己, 佐田尚宏, 深山正久, 永井秀雄
    日本外科学会雑誌  2001/03
  • 斉藤心, 佐田尚宏, 細谷好則, 塚原宋俊, 永井秀雄
    日本臨床外科学会雑誌  2001/02
  • 武神健之, 川口米栄, 小室安宏, 佐田尚宏, 久保田芳郎
    日本臨床外科学会雑誌  2001/02
  • 佐田尚宏, 永井秀雄, 武神健之, 川口米栄, 久保田芳郎
    日本臨床外科学会雑誌  2001/02
  • 膵頭十二指腸切除術後,腹腔動脈領域の虚血により,肝不全・縫合不全をきたした1例
    斉藤 心, 佐田 尚宏, 細谷 好則, 塚原 宗俊, 永井 秀雄
    日本臨床外科学会雑誌  2001/02  日本臨床外科学会
  • 栗原克己, 塚原宗俊, 吉沢浩次, 佐田尚宏, 永井秀雄
    日本臨床外科学会雑誌  2000/10
  • 武神健之, 川口米栄, 佐田尚宏, 久保田芳郎
    日本臨床外科学会雑誌  2000/06
  • 三上繁, 清水史郎, 浦木茂, 秋本政秀, 武神健之, 川口米栄, 佐田尚宏, 久保田芳郎
    Gastroenterol Endosc  2000/04
  • 武神健之, 佐田尚宏, 川口米栄, 三上繁, 久保田芳朗
    日本臨床外科学会雑誌  2000/03
  • Supraphysiologic concentrations of cerulein induce apoptosis in the rat pancreatic acinar cell line AR4-2J  [Not invited]
    N Sata, H Klonowski-Stumpe, B Han, R Luthen, D Haussinger, C Niederau
    PANCREAS  1999/07  LIPPINCOTT WILLIAMS & WILKINS
     
    Little is known as yet about the role of apoptosis in pancreatic damage. This study evaluated the effects of supraphysiologic concentrations of the cholecystokinin (CCK) analog, cerulein, which causes cell damage in vitro and acute pancreatitis in vivo, on cell proliferation and DNA fragmentation in the rat pancreatic acinar cell line AR4-2J. Cerulein inhibited the cell proliferation of AR4-2J time- and dose-dependently to similar to 60% of the control level at 10(-6) M after 72 h. DNA fragmentation, as assessed by both electrophoresis and enzyme-linked immunosorbent assay (ELISA), occurred at cerulein concentrations greater than or equal to 10(-8) M. The maximal DNA fragmentation as measured by ELISA was reached after 24 h. Cerulein at concentrations greater than or equal to 10(-9) M induced wild-type p53. Glutathione (1 mM) diminished the effects of cerulein on both cell proliferation and DNA fragmentation, whereas spermine (100 mu M), which partially attenuated DNA fragmentation, did not have an effect on cell proliferation. The CCK-A-receptor antagonist loxiglumide completely abolished the effect of cerulein on DNA fragmentation. The serine-protease inhibitor FUT-175 (10 mu M), the cysteine-protease inhibitor NCO-700 (5 mM), and ethylene glycol tetraacetic acid (EGTA; 500 mu M) all had no effects on the changes in cell proliferation and DNA fragmentation induced by cerulein, The elate suggest that supraphysiologic concentrations of cerulein rapidly induce apoptosis in AR4-2J cells and only later inhibit cell proliferation. These effects are mediated by CCK-A receptors, Cerulein-induced apoptosis may involve the induction of wild-type p53 or glutathione depletion or both.
  • Supraphysiologic concentrations of cerulein induce apoptosis in the rat pancreatic acinar cell line AR4-2J  [Not invited]
    N Sata, H Klonowski-Stumpe, B Han, R Luthen, D Haussinger, C Niederau
    PANCREAS  1999/07  LIPPINCOTT WILLIAMS & WILKINS
     
    Little is known as yet about the role of apoptosis in pancreatic damage. This study evaluated the effects of supraphysiologic concentrations of the cholecystokinin (CCK) analog, cerulein, which causes cell damage in vitro and acute pancreatitis in vivo, on cell proliferation and DNA fragmentation in the rat pancreatic acinar cell line AR4-2J. Cerulein inhibited the cell proliferation of AR4-2J time- and dose-dependently to similar to 60% of the control level at 10(-6) M after 72 h. DNA fragmentation, as assessed by both electrophoresis and enzyme-linked immunosorbent assay (ELISA), occurred at cerulein concentrations greater than or equal to 10(-8) M. The maximal DNA fragmentation as measured by ELISA was reached after 24 h. Cerulein at concentrations greater than or equal to 10(-9) M induced wild-type p53. Glutathione (1 mM) diminished the effects of cerulein on both cell proliferation and DNA fragmentation, whereas spermine (100 mu M), which partially attenuated DNA fragmentation, did not have an effect on cell proliferation. The CCK-A-receptor antagonist loxiglumide completely abolished the effect of cerulein on DNA fragmentation. The serine-protease inhibitor FUT-175 (10 mu M), the cysteine-protease inhibitor NCO-700 (5 mM), and ethylene glycol tetraacetic acid (EGTA; 500 mu M) all had no effects on the changes in cell proliferation and DNA fragmentation induced by cerulein, The elate suggest that supraphysiologic concentrations of cerulein rapidly induce apoptosis in AR4-2J cells and only later inhibit cell proliferation. These effects are mediated by CCK-A receptors, Cerulein-induced apoptosis may involve the induction of wild-type p53 or glutathione depletion or both.
  • New non-invasive technique of laparoscopic choledochotomy using abdominal wall lifting method and primary closure.  [Not invited]
    N Sata, Y Kawaguchi, Y Komuro, Y Kubota, S Saito, N Futakawa
    GASTROENTEROLOGY  1998/04  W B SAUNDERS CO
  • 大谷泰一, 跡見裕, 黒田慧, 新海宏, 佐田尚宏, 武藤徹一郎, 田村真郎, 福田覚, 赤尾周一
    日本臨床電子顕微鏡学会総会ならびに学術講演会予稿集  1993/09

MISC

  • 池田 恵理子, 牛尾 純, 安藤 梢, 谷川 雅彦, 坂口 美織, 三輪田 哲郎, 長井 洋樹, 多田 大和, 横山 健介, 菅野 敦, 森嶋 計, 笹沼 英紀, 玉田 喜一, 佐田 尚宏, 福嶋 敬宜  胆と膵  42-  (5)  393  -400  2021/05  
    胆膵領域に発生する腫瘍は、しばしば画像診断に難渋する。画像診断精度を向上させるためには、術前画像で異常所見を拾い上げる所見のための根拠を病理組織学的に検証していくことが重要である。当施設では、詳細な術前画像と病理像の対比のために、臨床医と病理医が協力して「検体造影検査」に加え「術後検体超音波検査」を行っている。とくに、「術後検体超音波検査」は、簡便で、病理像・画像対比に適した病理組織標本を作ることができ、画像所見へのフィードバックや診療科横断的なコミュニケーションツールとしても有意義な検査である。(著者抄録)
  • 池田 恵理子, 牛尾 純, 安藤 梢, 谷川 雅彦, 坂口 美織, 三輪田 哲郎, 長井 洋樹, 多田 大和, 横山 健介, 菅野 敦, 森嶋 計, 笹沼 英紀, 玉田 喜一, 佐田 尚宏, 福嶋 敬宜  胆と膵  42-  (5)  393  -400  2021/05  
    胆膵領域に発生する腫瘍は、しばしば画像診断に難渋する。画像診断精度を向上させるためには、術前画像で異常所見を拾い上げる所見のための根拠を病理組織学的に検証していくことが重要である。当施設では、詳細な術前画像と病理像の対比のために、臨床医と病理医が協力して「検体造影検査」に加え「術後検体超音波検査」を行っている。とくに、「術後検体超音波検査」は、簡便で、病理像・画像対比に適した病理組織標本を作ることができ、画像所見へのフィードバックや診療科横断的なコミュニケーションツールとしても有意義な検査である。(著者抄録)
  • 高橋 礼, 笹沼 英紀, 池田 恵理子, 三木 厚, 森嶋 計, 吉田 淳, 遠藤 和洋, 佐久間 康成, 堀江 久永, 細谷 好則, 北山 丈二, 瓦井Lefor Alan, 福嶋 敬宜, 佐田 尚宏  膵臓  36-  (2)  142  -149  2021/04  
    症例は37歳,女性.25歳で偶発的に膵体尾部に嚢胞性病変を指摘され,精査目的に当院消化器内科に紹介された.腹部造影CTとMRI検査では膵尾部に約5cmの嚢胞性腫瘤を認め膵粘液性嚢胞腫瘍(mucinous cystic neoplasm:MCN)が疑われたが,経過観察の方針となった.32歳時の第2子妊娠を契機に経過観察が一時中断となり,5年後の37歳に再診した.嚢胞性腫瘤は多房化し,大きさ6cmへの増大を認め,血清CA19-9の上昇を伴ったことから手術目的に消化器外科紹介となった.腹腔鏡下膵体尾部脾摘術を施行し,術後経過は良好で術後11日目に退院した.病理組織像では卵巣様間質を認め,微小浸潤を伴った膵粘液性嚢胞腺癌の診断であった.MCNの自然史を解明するには長期経過観察例の集積が必要である.(著者抄録)
  • 田口 昌延, 笹沼 英紀, 佐久間 康成, 山口 博紀, 菱沼 正一, 佐田 尚宏  膵臓  36-  (1)  82  -88  2021/02  
    膵癌においては外科治療が治癒の期待できる唯一の治療法であるが,手術侵襲についても十分に考慮されるべきである.2000年代以降,膵癌に対する化学療法・放射線治療の治療成績が目覚ましく向上する中で,集学的治療の一環として拡大手術の最新のエビデンスと位置づけを理解することは重要である.PV/SMV合併切除は比較的安全に施行可能で,R0切除になる場合に考慮される術式であり,術後治療が行えた場合は良好な予後が期待できる.動脈合併切除の意義は乏しいが,長期生存の報告もある.腹腔動脈合併切除を伴う尾側膵切除は合併症率が高く,症例・施設を厳選して行われるべきである.拡大リンパ節郭清の意義は否定されたが,至適リンパ節郭清範囲は未だ定まっていない.(著者抄録)
  • Tatsuya Ioka, Junji Furuse, Akira Fukutomi, Junki Mizusawa, Satoaki Nakamura, Nobuyoshi Hiraoka, Yoshinori Ito, Hiroshi Katayama, Makoto Ueno, Masafumi Ikeda, Kazuya Sugimori, Naohiro Okano, Kyoko Shimizu, Hiroaki Yanagimoto, Takuji Okusaka, Masato Ozaka, Akiko Todaka, Shoji Nakamori, Kazutoshi Tobimatsu, Naohiro Sata, Yohei Kawashima, Ayumu Hosokawa, Taketo Yamaguchi, Hiroyuki Miyakawa, Hiroki Hara, Nobumasa Mizuno, Hiroshi Ishii  Japanese journal of clinical oncology  51-  (2)  235  -243  2020/11  
    BACKGROUND: Chemoradiotherapy is a treatment option for locally advanced pancreatic cancer. However, the efficacy of induction chemotherapy prior to chemoradiotherapy is uncertain. The aim of this randomized, multicentre phase II study is to evaluate the efficacy and safety of chemoradiotherapy with and without induction chemotherapy to determine the significance of induction chemotherapy. METHODS: Patients with locally advanced pancreatic cancer were randomly assigned to the chemoradiotherapy arm (Arm A) or induction chemotherapy followed by the chemoradiotherapy arm (Arm B). Patients in Arm A underwent radiotherapy with concurrent S-1. Patients in Arm B received induction gemcitabine for 12 weeks, and thereafter, only patients with controlled disease underwent the same chemoradiotherapy as Arm A. After chemoradiotherapy, gemcitabine was continued until disease progression or unacceptable toxicity in both arms. The primary endpoint was overall survival. RESULTS: Amongst 102 patients enrolled, 100 were eligible for efficacy assessment. The probability of survival was greater in Arm B in the first 12 months, but the trend was reversed in the following periods (1-year survival 66.7 vs. 69.3%, 2-year survival 36.9 vs. 18.9%). The hazard ratio was 1.255 (95% confidence interval 0.816-1.930) in favour of Arm A. Gastrointestinal toxicity was slightly more frequent and three treatment-related deaths occurred in Arm A. CONCLUSIONS: This study suggested that the chemoradiotherapy using S-1 alone had more promising efficacy with longer-term survival, compared with induction gemcitabine followed by chemoradiotherapy for locally advanced pancreatic cancer. CLINICAL TRIAL REGISTRATION: The study was registered at the UMIN Clinical Trials Registry as UMIN000006811.
  • 井上 賢之, 川平 洋, 下村 義弘, 高久 美子, 堀江 久永, 佐田 尚宏  人間工学  56-  (5)  165  -169  2020/10  
    手術を介助する直接介助看護師は身体的負担が大きいことから、立位姿勢を支持する近未来的ウェアラブルチェアであるアルケリスを導入し、直接介助看護師の身体的負担軽減を試みた。アルケリスを装着した直接介助看護師に、腹腔鏡下手術(n=6)/開腹手術(n=6)従事後に10項目からなるアンケート調査を行った。アルケリスの各手術下での受容性は「全体的な使用感」、「使用ニーズ」、「器械出しのし易さ」、「安定感」をVisual Analog Scaleで評価した。装着時、非装着時の身体的負担はBorgスケールで計測した。アルケリスの使用は、重量・装着時の快適性などの改善が必要であるが、腹腔鏡下手術時において相対的に直接介助看護師の受容性は高く、特に安定感の面で顕著であった。(著者抄録)
  • 北山 丈二, 石神 浩徳, 山口 博紀, 斎藤 心, 倉科 憲太郎, 細谷 好則, 佐田 尚宏  臨床外科  75-  (10)  1185  -1189  2020/10  
    <文献概要>ポイント ◆タキサン腹腔内反復投与は長期にわたり高い腹腔内濃度が維持され,全身化学療法と併用することで胃癌腹膜播種に対して著効を示す.◆全身+腹腔内併用化学療法が奏効し「腹膜播種が消えた」症例に対し,conversion gastrectomyを施行すると長期生存が期待できる.◆全身+腹腔内併用化学療法中の腹腔内液サンプル中のCEAmRNAの定量は,conversion gastrectomyの適応を決めるうえで有用な情報となる.
  • 腹腔鏡下手術・開腹手術時における直接介助看護師のウェアラブルチェア使用の受容性
    井上 賢之, 川平 洋, 下村 義弘, 高久 美子, 堀江 久永, 佐田 尚宏  人間工学  56-  (5)  165  -169  2020/10  
    手術を介助する直接介助看護師は身体的負担が大きいことから、立位姿勢を支持する近未来的ウェアラブルチェアであるアルケリスを導入し、直接介助看護師の身体的負担軽減を試みた。アルケリスを装着した直接介助看護師に、腹腔鏡下手術(n=6)/開腹手術(n=6)従事後に10項目からなるアンケート調査を行った。アルケリスの各手術下での受容性は「全体的な使用感」、「使用ニーズ」、「器械出しのし易さ」、「安定感」をVisual Analog Scaleで評価した。装着時、非装着時の身体的負担はBorgスケールで計測した。アルケリスの使用は、重量・装着時の快適性などの改善が必要であるが、腹腔鏡下手術時において相対的に直接介助看護師の受容性は高く、特に安定感の面で顕著であった。(著者抄録)
  • 味村 俊樹, 本間 祐子, 佐田 尚宏  日本医師会雑誌  149-  (5)  851  -854  2020/08
  • 大澤 英之, 山口 博紀, 佐田 尚宏, 北山 丈二  Pharma Medica  38-  (7)  29  -34  2020/07  
    <文献概要>はじめに 腹膜播種は消化器がん,特に胃がんや膵がんにおいて最も頻度の高い転移・再発形式で,最大の予後規定因子である。近年のがん薬物療法の進歩によって,根治切除不能・再発がん患者の治療成績は著しく向上した。その一方で,腹膜播種に関してはいまだに顕著な予後改善はみられておらず,実臨床での大きな課題となっている。播種治療を困難にする要因の1つとして,治療効果を反映する適切なバイオマーカーがないことが挙げられる。一般に,個々の播種病変のサイズは数mm程度と小さく,CTスキャンなどの画像診断では検出されないことから,他の固形がんとは異なりRECIST(Response Evaluation Criteria in Solid Tumors)による治療効果の判定は困難である。腹膜播種の状況を最も正確に評価できるのは全身麻酔下での審査腹腔鏡であるが,侵襲を伴う手技であり頻回に行うことはできない。したがって,自覚症状や末梢血中腫瘍マーカーの値などに頼らざるを得ないが,これらの情報は必ずしも腹膜病変を正確に反映するわけではない。エクソソームは細胞が放出する30〜150nmの細胞外⼩胞で,さまざまな生理活性を有する蛋白質やDNA,マイクロRNA(miRNA)などの核酸成分を含有し,細胞間コミュニケーションに重要な役割を果たしている。近年の研究で,がん患者の血中エクソソームはがん特異的な機能分子を多量に含有しており,標的臓器の微⼩環境をがん細胞の生育に適したものに変換することによって,遠隔転移の成立を促進している事実が報告されてきている。腹膜播種をきたした患者では,原発巣から腹膜表面に播種したがん細胞が腹腔というフリースペースに直接接している。末梢血中の循環がん細胞が血液中の白血球106〜108個に対して数個のレベルで検証されているのに対し,播種患者の腹腔内液中の浮遊がん細胞は少なくとも104個の白血球に対して数個の割合で存在する。したがって,腹膜播種患者の腹腔内液は,血中に比べて圧倒的に多量のがん細胞特異的蛋白質やmiRNAを含んだエクソソームが放出されていることが予想される。体液中のエクソソームを対象とした研究では血液を使用したものが多いが,最近は腹水中のエクソソームを使用した報告も増えつつある。漿膜浸潤胃がんの腹腔内洗浄液中のエクソソームでmiR-21とmiR-1225-5pの発現が高いことや,卵巣がんの腹水中に含まれるエクソソーム中のMMP1のmRNAが腹膜中皮に作用して腹膜播種を引き起こすことが報告されている。われわれの研究室では,腹腔内液中に含まれるエクソソームに内包されるmiRNAに着目して,腹膜播種の成立や進展に関わる機序を明らかにし,腹膜播種患者の診療に応用できるバイオマーカーを開発することを目指している。
  • 高橋 和也, 堀江 久永, 井上 賢之, 太田 学, 鯉沼 広治, 佐田 尚宏  手術  74-  (6)  949  -954  2020/05  
    77歳男。会陰部の膨隆と疼痛を主訴とした。下部進行直腸癌に対する術前化学療法+腹腔鏡下腹会陰式直腸切断術後1ヵ月に絞扼性イレウスを発症し、緊急開腹手術を行ったが、術後に会陰部の膨隆と歩行障害を伴うほどの疼痛が出現した。腹部CTでは骨盤底への腸管の脱出はみられなかったが、会陰部皮下まで腹水の貯留を認め、会陰ヘルニアと診断して会陰ヘルニア修復術を行った。手術操作、合併症対策、ヘルニアの確実な修復の観点から経腹・経会陰の同時アプローチを選択し、前立腺から肛門挙筋で構成された3×3cmのヘルニア門をメッシュで被覆、固定した。本症例は放射線治療後であること、初回手術時に骨盤底の修復が行われていなかったことが会陰ヘルニア発症の一因と考えられた。
  • 【消化管症候群(第3版)-その他の消化管疾患を含めて-】空腸、回腸、盲腸、結腸、直腸(下) 腸閉塞 結腸軸捻症
    鯉沼 広治, 堀江 久永, 佐田 尚宏  日本臨床  別冊-  (消化管症候群IV)  316  -319  2020/05
  • 田口 昌延, 山口 博紀, 佐田 尚宏  膵臓  35-  (2)  193  -200  2020/04  
    膵癌の5年相対生存率は他の消化器癌と比較して著しく低く,膵癌は難治性癌の筆頭である.この疾患から長期生存を得る最良の方法は局所を根治切除し,術後に全身補助化学療法を行うこととされてきた.現在,膵癌のさらなる治療成績向上を目指し,術前治療が行われている.ここでは膵癌術後補助化学療法と術前治療について,最新の知見に基づいて解説する.JASPAC01試験からS-1による術後補助化学療法はわが国における標準治療になった.近年,FOLFIRINOX療法による補助化学療法の有用性が海外より報告された.切除可能膵癌においては,Prep-02/JSAP-05試験の結果より術前Gemcitabine+S-1療法が標準治療になる可能性がある.切除可能境界膵癌においては,術前治療の有効性を示す初のRCTが報告され,エビデンスの構築が進んでいる.局所進行切除不能膵癌に対する術前治療の意義は今後の検討課題である.(著者抄録)
  • 齋藤 晶, 春田 英律, 熊谷 祐子, 巷野 佳彦, アラン・K.・レフォー, 佐田 尚宏  自治医科大学紀要  42-  15  -18  2020/03  
    症例は55歳、女性。上腹部正中の腫瘤を主訴に当科を受診した。腹部CT検査にて上腹部正中に腹腔内から連続する脂肪組織と肝円索の腹膜前腔への逸脱を認め、白線ヘルニアと診断した。有症状の白線ヘルニアに対して単孔式腹腔鏡下手術(SILS)にて手術をする方針とした。臍に2本の5mmポートを留置したEZアクセス(八光)を用いてラッププロテクターに装着後。右側より2mmポートを留置し手術を施行した。上腹部正中に肝円索と脂肪組織が嵌頓していた。嵌頓したヘルニア内容を引き出し、2cmのヘルニア門を同定した。ヘルニア門はmeshを使用し、先端屈曲型のタッカーを使用し、double crown法で固定した。SILSでも先端屈曲式のタッカーと2mm鉗子を用いることで、整容性にも優れ、安全で確実な白線ヘルニア修復術が可能であった。(著者抄録)
  • 本間 祐子, 安田 是和, 北山 丈二, 細谷 好則, 堀江 久永, 佐久間 康成, Lefor Alan, 佐田 尚宏  自治医科大学紀要  42-  29  -34  2020/03  
    症例は55歳女性。4年前にC型慢性肝炎と診断されたが治療を自己中断していた。心窩部痛を主訴に来院。CTで肝S8に径8cmの低濃度腫瘍、肝内胆管拡張を認め肝内胆管癌と診断。右3区域切除を予定したが、術中に肝門板左側まで腫瘍浸潤を認め背景にC型肝炎も併存していたため1期的切除は困難と判断。2期的拡大肝右葉切除の方針へ変更し右門脈結紮術を施行した。治療目的に肝動注化学療法を3回施行したが効果なく、経過中に腫瘍の右横隔膜浸潤を認めたため根治切除は不能と判断、肝動脈化学塞栓療法(TACE)へ変更した。TACE1回目直後から腫瘍マーカーは低下し治療効果を認めた。発症から1年9ヵ月間に計7回のTACEを施行し腫瘍はコントロールされていたが、発症から2年2ヵ月目に腫瘍が増大し4年2ヵ月目に死亡した。遠隔転移のない局所進行肝内胆管癌に対し門脈結紮後にTACEを併施し有効な治療効果を得た1例を経験したので報告する。(著者抄録)
  • カレント・トピックス『膵癌診療ガイドライン2019年版』
    佐田 尚宏  日本医師会雑誌  148-  (11)  2212  -2212  2020/02
  • 齋藤 晶, 鯉沼 広治, 田原 真紀子, 森 和亮, 井上 賢之, 宮永 明子, 秋山 陽一郎, 天野 雄介, 堀江 久永, 佐田 尚宏  日本消化器外科学会雑誌  53-  (1)  22  -29  2020/01  
    症例は45歳の男性で,多発血管炎性肉芽腫症に対して当院アレルギー・リウマチ科で薬剤療法を開始した.開始後12日目に下腹部痛が出現し,腹部CTにて消化管穿孔と診断し緊急手術を施行した.小腸間膜対側に10mm以下の発赤を20ヶ所認め,うち2ヶ所の穿孔部を含む3ヶ所を部分切除した.術後経過は良好で,9日目に薬剤療法を再開した小腸穿孔部の病理組織学的検査所見では,血管壁への炎症細胞の浸潤を認め,多発血管炎性肉芽腫症に伴う消化管穿孔と診断した.術後53日目に絞扼性イレウスが疑われ緊急手術を施行したが,明らかな絞扼性イレウスや穿孔の所見は認めなかった.その後の経過は良好で,薬剤療法を再開,継続中である.今回の検討から多発血管炎性肉芽腫症に伴う消化管穿孔は重症化しやすく,潰瘍性病変が多発する傾向にあり,ときに再穿孔を来すことがわかった.これらを十分理解し,患者・家族へ説明し,治療にあたることが必要である.(著者抄録)
  • 金丸 理人, 北山 丈二, 佐田 尚宏  Thrombosis Medicine  9-  (4)  319  -324  2019/12  
    好中球細胞外トラップ(NETs)上に存在する好中球エラスターゼ(NE)やマトリックスメタロプロテアーゼ(MMP)-9は、がん細胞の形質転換や細胞外基質のリモデリングを介してがん細胞の浸潤を促進する作用を有する。また、肺や肝臓の血管床や腹膜表面にNETsが存在すると、その場で遊離がん細胞を捕捉することで転移の成立を促進し、DNase IによるNETsの分解がこの転移形成を抑制することが証明されている。がん患者は腫瘍が産生する因子によりNETsを形成しやすい状態にあると考えられ、NETsを標的とした新しいがん治療法の開発に期待が持たれる。(著者抄録)
  • 眞田 幸弘, 佐久間 康成, 佐田 尚宏  Medical Technology  47-  (13)  1378  -1386  2019/12  
    ●生体肝移植ドナーとレシピエントの術前超音波検査は、肝移植適応や全身状態の評価を行う点で重要である。●肝移植術後超音波検査は、症例ごとに術式や起こりうる病態を把握したうえで定期的に行うべきである。●超音波検査により、肝移植後合併症の早期診断・早期治療を行うことができる。●肝移植周術期管理において、超音波ガイド下検査・治療は重要である。(著者抄録)
  • 正宗 淳, 入澤 篤志, 菊田 和宏, 池浦 司, 伊佐地 秀司, 石黒 洋, 糸井 隆夫, 伊藤 鉄英, 乾 和郎, 大原 弘隆, 片岡 慶正, 神澤 輝実, 岸和田 昌之, 北野 雅之, 阪上 順一, 佐田 尚宏, 清水 京子, 竹中 完, 竹山 宜典, 能登原 憲司, 廣岡 芳樹, 松本 逸平, 宮川 宏之, 岡崎 和一, 日本膵臓学会, 日本膵臓学会膵炎調査研究委員会慢性膵炎分科会  膵臓  34-  (6)  279  -281  2019/12
  • 正宗 淳, 入澤 篤志, 菊田 和宏, 池浦 司, 伊佐地 秀司, 石黒 洋, 糸井 隆夫, 伊藤 鉄英, 乾 和郎, 大原 弘隆, 片岡 慶正, 神澤 輝実, 岸和田 昌之, 北野 雅之, 阪上 順一, 佐田 尚宏, 清水 京子, 竹中 完, 竹山 宜典, 能登原 憲司, 廣岡 芳樹, 松本 逸平, 宮川 宏之, 岡崎 和一, 日本膵臓学会膵炎調査研究委員会慢性膵炎分科会  膵臓  34-  (6)  282  -292  2019/12  
    現行の「慢性膵炎臨床診断基準2009」が提唱されてから10年間が経過した。世界ではじめて早期慢性膵炎の概念を取り入れた診断基準であるが、その後蓄積された知見や膵炎診療の変化をふまえて、その改訂が必要となっていた。今回、日本膵臓学会膵炎調査研究委員会慢性膵炎分科会が中心となり、診断基準の改訂を行った。新基準「慢性膵炎臨床診断基準2019」の最大の特徴は、mechanistic definitionを慢性膵炎の概念として取り入れ、早期慢性膵炎の診断項目を危険因子の観点から改訂したことである。新たに膵炎関連遺伝子異常と急性膵炎の既往を診断項目に組み入れ、診断特異度の向上を意図した。さらに、多量飲酒歴の基準を純エタノール換算80g/日から60g/日に変更するとともに、画像診断としてMRCP所見の格上げ、早期慢性膵炎の画像所見の整理を行った。新しい診断基準が慢性膵炎診療のさらなる質の向上や患者の予後改善に寄与することが期待される。(著者抄録)
  • 佐田 尚宏  胆と膵  40-  (臨増特大)  1195  -1198  2019/11  
    アルコール摂取は膵炎におけるもっとも頻度の高い原因であるにもかかわらず、飲酒例のなかで膵傷害をきたす割合は10%程度に過ぎず、機会飲酒程度のアルコール摂取量で膵炎を起こす症例もあり、アルコールによる膵傷害成立機序には不明の点が多い。2009年に改訂された慢性膵炎診断基準では、早期慢性膵炎の概念がはじめて定義され、アルコール摂取に関して「1日80g以上(純エタノール換算)の持続する飲酒歴」が早期慢性膵炎診断基準の一つにあげられた。アルコール性の早期慢性膵炎は、飲酒継続で慢性膵炎に進展する例があることが明らかになり、早期診断のもと断酒を含めた生活指導がアルコール性膵炎の進展抑制に重要であることが再認識される。最近では、PRSS1、SPINK1、CPA1などの膵炎関連遺伝子異常についての研究が進行していて、このような遺伝子学的アプローチが今後のアルコール性膵炎の病態解明につながることが期待される。(著者抄録)
  • 佐田 尚宏  膵臓  34-  (4)  125  -127  2019/08  
    膵臓の切離・再建に伴う合併症は外科手技、手術機器が進歩した現在でも難治であり、膵切除術後合併症を如何に逓減、根絶するかは現代の膵臓外科医にとって最も重要なテーマである。膵切除術の合併症のなかで、最も難治なのは膵液瘻(pancreatic fistula)で、2005年BassiらInternational Study Group on Pancreatic Fistula Definition(ISGPF)がpostoperative pancreatic fistula(POPF)の定義を提唱し、手術成績評価の標準化が進んだ。本邦では学会・研究会を母体とした多施設共同研究、National Clinical Database(NCD)登録データを用いたコホート研究が行われるようになってきたが、膵液瘻をはじめとした膵切除術の合併症は、未だ解決されていない今日的な課題であり続けている。(著者抄録)
  • 各科臨床のトピックス 排便障害診療の進歩と課題
    味村 俊樹, 本間 祐子, 堀江 久永, 佐田 尚宏  日本医師会雑誌  148-  (4)  698  -699  2019/07
  • 佐々木 裕美子, 藤田 崇史, 天野 雄介, 田中 宏幸, 田中 昌宏, 佐田 尚宏  臨牀と研究  96-  (5)  595  -597  2019/05  
    35歳女性。発赤と疼痛を伴う左乳房腫瘤を主訴に近医を受診、左乳腺炎として抗菌薬CFPN-PI(Cefcapene pivoxil)を投与されるも改善せず、当科へ紹介となった。乳房超音波では左乳房AC領域にプローブのスケールを超える境界不明瞭な低エコー腫瘤がみられ、内部は不均一で一部嚢胞様構造を呈していた。また、乳房MRIではダイナミック造影で左乳房AC領域を中心に最大径95mmの造影効果を伴う腫瘤を認め、内部には複数のリング状濃染される結節性病変を認めた。以上、これらの所見のほか、乳房膿様分泌液からの細菌培養により、本症例はCorynebacterium属感染による巨大肉芽腫性乳腺炎を考え、抗菌薬であるLVFXの内服とドレナージによる感染コントロールを行い、次いで少量のステロイド内服を開始したところ、左乳房腫瘤は徐々に蝕知されなくなり、治癒が得られた。
  • 田原 真紀子, 堀江 久永, 熊谷 祐子, 井上 賢之, 鯉沼 広治, 佐田 尚宏  日本内視鏡外科学会雑誌  24-  (3)  245  -252  2019/05  
    <文献概要>症例1は57歳,男性.直腸癌(Rab)に対し腹腔鏡下低位前方切除+回腸人工肛門造設術を施行した.症例2は54歳,男性.直腸癌(Ra)に対し腹腔鏡下低位前方切除術を施行した.症例3は67歳,男性.直腸癌(Rb)に対し腹腔鏡下直腸切断術+左側方郭清を施行した.体位は砕石位で両下腿に間欠性空気圧迫装置を装着し,頭低位・右側低位としていた.手術時間は各々575分,310分,619分でいずれも術直後より左下腿の硬結・圧痛を認めた.CTで左下腿筋の造影不良・浮腫を認め下肢コンパートメント症候群と診断し,保存的治療にて軽快した.下肢コンパートメント症候群は時に後遺障害を残すことのある重篤な合併症である.文献的考察を踏まえ,筆者らの対応策を含めて報告する.
  • 扇原 香澄, 塩澤 幹雄, 秋根 大, 富永 経一郎, 佐田 尚宏  日本臨床外科学会雑誌  80-  (4)  668  -674  2019/04  
    症例は83歳,女性.糖尿病,徐脈頻脈症候群に対してペースメーカー埋込術後,ダビガトランを内服中であった.農作業の積載中,右胸部痛が出現し,右上肢挙上困難となり,翌日に救急外来を受診した.初診時同部位に発赤腫脹を認めた.CTでは乳房領域の皮下脂肪織濃度上昇,大胸筋の腫脹を認めたが,遊離ガスは認めなかった.抗凝固薬内服に伴う筋肉内出血を疑ったが,受診5時間後に血圧低下をきたし全身管理となった.筋膜生検・Gram染色・溶連菌キット検査にてA群溶血性連鎖球菌感染による壊死性筋膜炎と診断し,抗菌薬(VCM,TAZ/PIPC,CLDM)の投与,右乳房を中心に広範囲debridementを施行した.後日,血液/組織培養でも同菌が同定された.治療に反応せず術後1日目に死亡した.壊死性筋膜炎は四肢に発症することが多く,体幹発症は稀であり診断が難しい.本症例から壊死性筋膜炎の診断,治療,対応について考察する.(著者抄録)
  • 直井 大志, 鯉沼 広治, 堀江 久永, 太田 学, 佐田友 藍, 清水 徹一郎, 田原 真紀子, 伊藤 誉, 巷野 佳彦, 井上 賢之, 味村 俊樹, 佐田 尚宏  日本大腸肛門病学会雑誌  72-  (4)  165  -170  2019/04  [Not refereed][Not invited]
     
    症例は43歳女性。S状結腸癌、転移性肝腫瘍、左卵巣腫瘍に対し腹腔鏡下S状結腸切除・肝部分切除・左付属器切除術が施行された。術後4ヵ月目に発症した絞扼性腸閉塞に対して緊急手術が施行された。原因はS状結腸の腸間膜欠損部と初回手術時に温存された上直腸動脈間が門となる内ヘルニアであった。小腸部分切除、腸間膜欠損部の縫合閉鎖を行った。腹腔鏡下大腸切除手術後、腸間膜欠損部が原因の内ヘルニアの発生率は少なく、腸間膜欠損部は閉鎖しないことが一般的である。本症例は、S状結腸が過長で、腸間膜と後腹膜の癒合が少ないという特徴があった。このような症例では術後の癒着による腸間膜欠損部の閉鎖がされず、内ヘルニアのリスクが高いと考えられ、閉鎖すべきと考えられた。(著者抄録)
  • 直井 大志, 堀江 久永, 鯉沼 広治, 熊谷 祐子, 津久井 秀則, 東條 峰之, 宮原 悠三, 太田 学, 本間 祐子, 佐田友 藍, 清水 徹一郎, 田原 真紀子, 森 和亮, 巷野 佳彦, 伊藤 誉, 井上 賢之, 味村 俊樹, Kawarai Lefor Alan, 佐田 尚宏  自治医科大学紀要  41-  7  -13  2019/03  [Not refereed][Not invited]
     
    右側結腸手術の周術期管理に、Enhanced Recovery After Surgeryプロトコル(ERAS)を導入したので短期成績を報告する。2014年6月から2017年10月に行われた右側結腸手術症例をERAS群、2010年1月から2014年5月の症例を従来群とし、後方視的に検討した。ERAS群では、機械的前処置の省略、術直後の胃管抜去、早期経口摂取開始を新たに採用した。ERAS群182例(腹腔鏡103例、開腹79例)、従来群202例(腹腔鏡84例、開腹118例)であった。腹腔鏡手術では、ERAS群と従来群で手術関連因子、術後合併症に差は認めなかった。開腹手術では、表層性の創部感染の発生率はERAS群で有意に高かった(ERAS群12.7%:従来群2.5%)が、Clavien-Dindo分類2以上の術後合併症はERAS群で有意に低かった(ERAS群3.8%:従来群18.6%)。右側結腸手術において当科のERASプロトコルは安全に導入可能である。(著者抄録)
  • 川平 洋, レフォー アラン, 佐田 尚宏, 中村 亮一, 前田 佳孝, 鈴木 義彦, 浅田 義和, 遠藤 和洋, 佐久間 康成, 細谷 好則, 堀江 久永  生体医工学  57-  S200_1  -S200_1  2019  

    昨今の内視鏡外科手術の普及に伴い、シミュレーション教育や手術トレーニング環境の整備が進んだ。特に内視鏡外科手術では、外科医は体腔内臓器をモニタ画像情報で判断し、手術を行う。特に執刀医、助手すべてが同じ術野を共有することから、オンサイトでのトレーニングが可能である。手術映像を記録可能なことから、繰り返し再生によるオフサイトトレーニングも広く行われている。実際の手術を想定したオフサイトでのタスクトレーニングは、最善の手術を完遂する上で重要である。開腹手術に比較し多様な機材を使用する内視鏡外科手術では、高忠実度(Hi-Fi)臓器モデルによる手術トレーニングも行われている。Hi-Fiモデルでは、より実践に近い感覚でトレーニングを行うことが可能と考えられる。このような臓器モデルはシリコン樹脂やPVAなどの石油原料由来の臓器モデルが主である。ところがトレーニングモデルにおいても廃棄物の問題は重要であり、マンナンなどの植物由来原料を用いたタスクトレーニングモデルも開発されている。継続してトレーニングが必要な手術教育においては、コストを含めた持続可能なトレーニング環境の整備が必須である。

  • 田中 裕美子, 石黒 保直, 丸山 博行, 遠藤 和洋, 佐田 尚宏, 安田 是和  臨牀と研究  95-  (12)  1388  -1391  2018/12  
    症例は66歳男性で、下血、血圧低下により当院に緊急搬送された。上部消化管内視鏡検査では、十二指腸球部は変形し、前壁と思われる部位に露出血管を伴う潰瘍を認めた。クリップによる止血を試みたが、3本目をかけたところで噴出性に出血し、内視鏡的止血は困難と判断しIVRに移行した。血管造影検査では、固有肝動脈側壁の近傍に内視鏡クリップを認め、十二指腸内に出血していた。大量輸血後もショック状態が持続していたため固有肝動脈塞栓を行ったが、塞栓後もクリップ近傍から緩徐に出血を認め、止血目的に緊急手術を施行した。総肝動脈および胃十二指腸動脈を露出し、潰瘍穿通部の固有肝動脈へ流入する総肝動脈・胃十二指腸動脈および肝門側の固有肝動脈を切離せずに二重結紮で血流を遮断した。十二指腸開放部は1層に縫合閉鎖し、さらに大網を縫着した。ウィンスロー孔にドレーンを留置し、閉腹し手術を終了した。術後10日目、発熱と上腹部痛が出現し、CTでは肝左葉に低吸収域と横隔膜経由と考えられる側副血行路を認めた。肝膿瘍の診断で緊急開腹ドレナージを行い、膿瘍部にドレーンを留置した。ドレナージ後は速やかに解熱し腹痛も消失した。術後51日目、ドレーンを抜去し退院したが、10日後に高熱と肝膿瘍ドレナージ創から胆汁様滲出液が出現し、減圧目的に胆管ステントを留置した。術後1年5ヵ月、ERCPで胆管狭窄が改善していることを確認し、胆管ステントを抜去した。半年後のCTでは肝膿瘍や胆管狭窄は認めなかった。
  • 直腸穿通をきたした卵巣成熟嚢胞性奇形腫の1例
    松本 健司, 井上 賢之, 坂口 美織, 森 和亮, 鯉沼 広治, 堀江 久永, アラン K.・レフォー, 北山 丈二, 佐田 尚宏  日本外科系連合学会誌  43-  (6)  1143  -1148  2018/12  [Not refereed][Not invited]
     
    症例は48歳,女性.数日前からの血便を主訴に当院を受診した.腹部造影CTでは,腹腔内に腹水貯留やfree airは認められなかった.両側の卵巣には嚢胞成分を含む腫瘤性病変を認め,特に右卵巣は内部に高吸収域を有し直腸に近接していた.卵巣腫瘍による直腸浸潤もしくは直腸腫瘍による卵巣浸潤が疑われ,精査目的に同日緊急入院となった.下部消化管内視鏡を施行したところ,直腸Raに毛髪が付着した腫瘤が穿通している所見を認めた.卵巣奇形腫の直腸穿通が疑われたが腹膜炎所見を認めなかったため,待機的手術の方針とした.良悪性の鑑別が困難であったため,術中迅速病理所見により切除範囲を検討する方針とし,入院第9日目に手術を施行した.術中所見では両側の卵巣・直腸・子宮が一塊となっており両側附属器切除術・低位前方切除術・子宮全摘術を施行した.迅速病理では卵巣成熟嚢胞性奇形腫の診断であり,リンパ節郭清は行わず,手術終了とした.経過良好で術後10日目に退院となった.卵巣成熟嚢胞性奇形腫による消化管穿通例の報告は比較的稀である.良性症例だけでなく悪性症例も存在し,手術対応が異なるため,正確な術前術中診断が必要である.(著者抄録)
  • 【ここまで来た ナビゲーション手術】胆道癌、膵癌に対するナビゲーション手術 三次元モデルによる術前シミュレーション、術中ナビゲーションおよびシミュレーション・トレーニング
    遠藤 和洋, 佐田 尚宏, 太白 健一, 木村 有希, 青木 裕一, 田口 昌延, 森嶋 計, 三木 厚, 吉田 淳, 小泉 大, 笹沼 英紀, 佐久間 康成  消化器外科  41-  (9)  1317  -1327  2018/08
  • 伊藤 誉, 堀江 久永, 直井 大志, 田原 真紀子, 森 克亮, 巷野 佳彦, 井上 賢之, 有田 宗史, 鯉沼 広治, 佐田 尚宏  Gastroenterological Endoscopy  60-  (7)  1331  -1337  2018/07  
    大腸内視鏡が左鼠径ヘルニアに嵌入し挿入困難になった3例を経験した。症例はいずれも高齢の男性であった。1例は慎重に抜去を行った後、脱出した腸管を徒手整復手技に準じて還納することで全大腸内視検査が施行可能であったが、その他2例は検査の継続が不可能であった。大腸内視鏡は広く普及している手技であるが、検査中に内視鏡が鼠径ヘルニアに嵌入した報告は極めて少ない。大腸内視鏡検査を行う上で、高齢の男性では陰嚢腫脹を伴う外鼠径ヘルニアの病歴聴取が重要である。大腸内視鏡検査中に予期せず内視鏡が鼠径ヘルニアに嵌入した場合は、一旦手技を中断し、鼠径部痛などの臨床症状の確認を行った後、慎重に抜去するのが望ましい。(著者抄録)
  • 金子 勇貴, 小泉 大, 井上 賢之, 堀江 久永, 細谷 好則, 佐田 尚宏  日本臨床外科学会雑誌  79-  (6)  1319  -1323  2018/06  
    76歳,女性.心窩部痛を主訴に救急搬送された.開腹歴なし.左鼠径部腫瘤を触知し,単純X線で小腸ガスを認め,左鼠径ヘルニア嵌頓による腸閉塞と診断された.用手的整復後,経過観察入院となった.腸閉塞の改善がなく,翌日の造影CTで右坐骨孔に腸管脱出を認め,右坐骨ヘルニア嵌頓の診断で緊急手術となった.腹腔鏡下観察で右坐骨ヘルニアを認めたが,嵌頓は既に解除されていた.腸管壊死を疑い開腹すると,回腸にRichter型嵌頓を起こしていた所見があった.壊死所見なく腸切除はしなかった.ヘルニア門は卵巣等周囲組織で被覆閉鎖した.術後は肺炎などのため,第35病日に退院となった.腹壁ヘルニア嵌頓時には他のヘルニアの合併に留意し,嵌頓解除後の症状観察が重要である.坐骨ヘルニアの診断・治療方針の決定に造影CT,腹腔鏡観察が有用であった.(著者抄録)
  • 笹沼 英紀, 佐田 尚宏, 小泉 大, 笠原 尚哉, 三木 厚, 遠藤 和洋, 佐久間 康成, 堀江 久永, 細谷 好則, Alan瓦井 Lefor  小切開・鏡視外科学会雑誌  9-  (1)  47  -51  2018/06  [Refereed][Not invited]
     
    症例1は30歳男性で、発熱と左腹部痛で来院した。CTで感染性Walled-off necrosis(WON)と診断し、保存的治療を行ったが、症状ならびに炎症所見の改善を認めず、インターベンション治療目的に当院転院となった。造影CT所見から壊死物質を主成分とした感染性WONと診断し、小切開Videoscope補助下に後腹膜経路でネクロセクトミーを行った。1回のネクロセクトミーで炎症所見とCT所見は速やかに改善し、追加の処置は不要となった。左後腹膜のドレーンは留置したまま入院40日目に退院した。症例2は34歳男性で、急性膵炎の診断で保存的治療が開始され、退院約2週間後に間歇的腹痛と発熱で来院し、炎症反応高値、CTで感染性WONと診断され再入院した。造影CT所見から膵体尾部の壊死物質を主成分とする左側感染性WONと診断し、腹腔経路で小切開Videoscope補助下にネクロセクトミーを行った。その後、右側WON増大による閉塞性黄疸が出現し、開腹ネクロセクトミーと胆道ドレナージが必要となった。症状出現から7ヵ月後、ERCPで左右肝管にERBD tubeを留置し退院した。
  • Makoto Ueno, Chigusa Morizane, Takuji Okusaka, Junki Mizusawa, Hiroshi Katayama, Masafumi Ikeda, Masato Ozaka, Kazuya Sugimori, Akira Fukutomi, Hiroki Hara, Nobumasa Mizuno, Hiroaki Yanagimoto, Keiji Sano, Kazutoshi Tobimatsu, Kei Yane, Shoji Nakamori, Naohiro Sata, Seigo Yukisawa, Hiroshi Ishii, Junji Furuse  JOURNAL OF CLINICAL ONCOLOGY  36-  (15)  2018/05
  • シニアレジデントに対する腹腔鏡下結腸切除術のトレーニングプログラム
    堀江 久永, 鯉沼 広治, 井上 賢之, 佐田友 藍, 巷野 佳彦, 森 和亮, 森本 光昭, 佐田 尚宏  日本内視鏡外科学会雑誌  23-  (3)  297  -303  2018/05  [Not refereed][Not invited]
     
    <文献概要>当科におけるシニアレジデントに対する腹腔鏡下結腸切除術トレーニングプログラムの結果を報告する.2014年4月から2017年3月までに20名が参加した.初期1ヵ月にカメラ助手を経験後,1日間の動物実習,残り3ヵ月間に内視鏡外科技術認定医指導下に術者を経験した.63症例の手術がレジデントにより施行された.回盲部切除術(40例)とS状結腸切除術(23例)の手術時間(中央値)はそれぞれ190分と232分であった.51/63例(81%)で術者交代なく完遂されていた.術後,縫合不全やイレウスなどの重篤な合併症は認められなかった.シニアレジデントによる腹腔鏡下結腸切除術は本プログラム下に安全に施行されていた.
  • 長谷川直人, 樅山定美, 中野真理子, 佐々木雅史, 吉田紀子, 古島幸江, 佐々木彩加, 中村美鈴, 佐藤幹代, 村上礼子, 相賀美幸, 宮田直美, 渡辺芳江, 半田知子, 弘田智香, 倉科憲太郎, 細谷好則, 佐田尚宏  自治医科大学看護学ジャーナル  15-  3‐15  2018/03  [Not refereed][Not invited]
  • 井上 賢之, 横田 真一郎, 金丸 理人, 森嶋 計, 石黒 保直, 小泉 大, 近藤 康雄, 佐田 尚宏  自治医科大学紀要  40-  29  -34  2018/03  
    症例は78歳、女性。右閉鎖孔に脱出する嚢胞状構造を認めていたが無症状のため経過を見ていた。下腹部痛を主訴に受診し、右閉鎖孔に小腸の脱出を認め用手的に還納した。その後も嚢胞状構造が遺残していたため、精査を施行、閉鎖孔に滑脱した膀胱ヘルニアと診断し、待機的手術の方針となった。下腹部正中切開を置き、腹腔内より右閉鎖孔を確認した。小腸壁は一部嵌入していたが、軽い牽引で容易に閉鎖孔から還納された。骨盤底腹膜を切開し、大きく張り出した膀胱を右閉鎖孔より引き出し、閉鎖孔と膀胱との間に形状維持メッシュPolySoftを留置した。閉鎖孔に滑脱した膀胱ヘルニアでは、年齢、状態を考慮し保存的に経過をみることも可能であるが、腸管脱出合併例では積極的な修復手術が考慮されるべきと考えられた。(著者抄録)
  • 太田 学, 三木 厚, 遠藤 和洋, 佐久間 康成, アラン K.・レフォー, 佐田 尚宏  日本臨床外科学会雑誌  79-  (2)  405  -411  2018/02  
    症例は44歳,女性.主訴は心窩部不快感.CTで膵尾部に径約70mmの嚢胞性病変,それと連続し胃壁内に小嚢胞の集簇を認めた.経過観察中に突然の腹痛で当院へ救急搬送され,CTで胃側の嚢胞が長径95mmと増大しており入院した.超音波内視鏡検査で胃側の嚢胞は胃壁筋層内に存在し,膵尾部の嚢胞との交通を認めた.穿刺内容液は血性で,内容液中のamylase(AMY),CEAが高値であった.膵粘液性嚢胞腫瘍(MCN)が胃壁内へ穿破したことによる胃壁筋層内出血と診断し,待機的に手術を行った.手術は膵体尾部脾合併切除を行い,胃側の嚢胞は胃壁の筋層を温存し嚢胞壁のみ合併切除した.膵嚢胞内容液のAMY,CEAは高値で胃壁側の嚢胞液と類似していた.病理組織診断ではMCNの診断であった.MCNが膵管と交通を持ち,胃壁筋層内へ穿破し出血を生じたと考えられる1例を経験したため,文献的考察も含めて報告する.(著者抄録)
  • TANIGUCHI Masatake, SAKUMA Yasunaru, KOIZUMI Masaru, SASANUMA Hideki, LEFOR Alan Kawarai, SATA Naohiro  Nihon Rinsho Geka Gakkai Zasshi (Journal of Japan Surgical Association)  79-  (9)  1922  -1927  2018  [Refereed][Not invited]
     
    We report the case of a 70-year-old man who was incidentally detected as having a hepatic mass. The mass was 25 mm in diameter and located in segment 3. Plain CT revealed the lesion as a low density area and dynamic CT showed a hyper-vascular lesion in the early phase and wash out in the delayed phase. MRI showed a hypo-intense area on T1-weighted images and in the hepatobiliary phase. The mass was visualized as a hyper-intensity on T2-weighted MR images and showed a low signal on diffusion-weighted MR images. Ultrasonography showed an isoechoic area with a halo and posterior echo enhancement. Serum tumor marker levels were normal. We diagnosed the tumor as hepatocellular carcinoma and performed laparoscopic partial hepatectomy. Histopathologically, the mass consisted of necrotic tissue surrounded by a thick capsule. The necrotic tissue consisted of hepatic cords and lipid droplets with neutrophil infiltration. There were no viable tumor cells. We diagnosed the lesion as representing spontaneous complete regression of hepatocellular carcinoma or a solitary necrotic nodule. The features of a solitary necrotic nodule are a necrotic core, hyalinized fibrotic tissue and elastic fibers. The capsule component was composed not of elastic fibers, but of collagen fibers. Finally, we diagnosed the lesion as most likely representing spontaneous regression of HCC, and the patient is under careful follow-up.
  • INOUE Yoshiyuki, KANAMARU Rihito, YOKOTA Shinichiro, MORISHIMA Kazue, ISHIGURO Yasunao, KOIZUMI Masaru, SASANUMA Hideki, SATA Naohiro  GASTROENTEROLOGICAL ENDOSCOPY  60-  (4)  997  -1002  2018  [Refereed][Not invited]
     

    A 79-year-old woman who suffered from anorexia, nausea, and discomfort in the upper abdomen, presented to our hospital. Abdominal computed tomographic (CT) scan and esophagogastroduodenoscopy revealed a large hepatic cyst with air fluid level and a fistula between the duodenal bulb and the hepatic cyst. The diagnosis of hepatoduodenal fistula was made. We first chose conservative management because there were no signs of acute panperitonitis. As the fistula decreased in size, it did not function as a drainage route from the hepatic cyst. The hepatic cyst became infected and required small incision laparotomy and placement of a drainage tube. As a result, the fistula closed spontaneously over time and the hepatic cyst shrunk. We could avoid emergent or elective laparotomy by performing non-invasive treatment. It may be critical to drain out food residue and intestinal fluid from a hepatic cyst by placing a drainage tube through the percutaneous transhepatic route in conservative management of a hepatoduodenal fistula.

  • 武田 宏司, 田口 昌延, 佐田 尚宏, 矢田 俊彦  肥満研究  23-  (3)  218  -225  2017/12  
    近年、肥満のみならずやせ・低栄養も大きな問題となっている。成人における低栄養は、悪液質、侵襲、飢餓に分類される。悪液質は、癌患者などにおいて、体重減少や全身倦怠感をきたした状態であり、病態の中心は食欲不振によるエネルギー摂取低下とサイトカインによるエネルギー消費増大である。悪液質の特徴は、栄養療法だけでは十分な改善が得られないことであり、運動や薬物も含めた包括的対応が必要である。悪液質に対する薬剤として、グレリン受容体作動薬、抗サイトカイン薬、選択的アンドロゲン受容体調節薬などが開発中であるが、なかでもグレリン受容体作動薬anamorelinは臨床応用に最も近い。胃全摘後の食欲不振、体重減少のメカニズムは不明な点が多く、現在でも有効な改善策がない。著者らは、ラット胃全摘モデルを用い、胃全摘後の摂食低下、体重減少の成因解明を目的として研究をおこなった。胃全摘後にラットの摂食量と体重が減少し、血中GLP-1濃度が有意に上昇した。食欲改善作用を有する六君子湯の投与により、術後の摂食量と体重が増加し、血中GLP-1濃度上昇が有意に抑制された。ヒトにおいても胃全摘後に空腹時血中GLP-1濃度が上昇することが明らかとなっており、六君子湯は胃全摘後の食欲改善薬として期待される。一般的に、急性のストレスは食欲を低下させる。他方、慢性ストレスは体重を減少させる場合と増加させる場合がある。その理由として、ストレスの種類や強さに加えて、BMIや性・年齢などの個体差の影響が大きいと考えられる。著者らは、動物モデルを用いた検討により、ストレスによる摂食・体重変化は脳内の5-HT2C受容体の影響を強く受けること、この受容体の機能が性・年齢により大きく異なることを明らかにした。(著者抄録)
  • 佐田 尚宏, 齋藤 晶, 木村 有希, 青木 裕一, 田口 昌延, 笠原 尚哉, 森嶋 計, 三木 厚, 兼田 裕司, 遠藤 和洋, 小泉 大, 笹沼 英紀, 吉田 淳, 清水 敦, 佐久間 康成, 栗原 克己, 大木 準, 鈴木 正徳  臨床外科 = Journal of clinical surgery  72-  (8)  986  -989  2017/08  [Refereed][Not invited]
  • クリニカルカンファレンスから(第11回) 自治医科大学附属病院の症例 心臓疾患など重複疾患に対し連携治療を行った結果、無事手術に至った症例
    岡田 健太, 春田 英律, 今井 靖, 淺川 智香子, 石橋 和世, 千葉 円香, 佐藤 敏子, 石橋 俊, 細谷 好則, 佐田 尚宏  肥満症治療学展望  (11)  6  -8  2017/06
  • 浦橋 泰然, 笠原 尚哉, 寺谷 工, 北山 丈二, 佐田 尚宏, 水田 耕一  小児外科  49-  (5)  505  -508  2017/05  [Not refereed][Not invited]
  • 佐田 尚宏, 遠藤 和洋, 小泉 大, 笹沼 英紀, 佐久間 康成  最新医学  別冊-  (胆石症・胆管結石・胆道炎・胆道がん)  171  -176  2017/04  
    十二指腸乳頭部がんの外科治療において最も問題となるのは,深達度が乳頭部粘膜内にとどまる(T1a)か,Oddi筋に達する(T1b)かで,T1a以浅とT1b以深とでは治療の考え方が大きく異なる.Stage0〜IAの乳頭部がんの中には,内視鏡的,外科的乳頭切除術で治癒する症例は存在するが,『エビデンスに基づいた胆道癌診療ガイドライン改訂第2版』(2014年)で推奨される標準治療は,StageIB〜IIIと同様に,(幽門輪温存,亜全胃温存)膵頭十二指腸切除術である.(著者抄録)
  • 熊谷 祐子, 堀江 久永, 佐田友 藍, 直井 大志, 清水 徹一郎, 巷野 佳彦, 田原 真紀子, 井上 賢之, 伊藤 誉, 森本 光昭, 鯉沼 広治, 佐田 尚宏  日本大腸肛門病学会雑誌  70-  (4)  227  -232  2017/04  [Not refereed][Not invited]
     
    症例は31歳女性.3ヵ月前からの便秘を主訴に近医を受診した.大腸内視鏡検査で直腸腫瘍を認め,Boring生検で神経鞘腫と診断され当院に紹介された.直腸診では肛門管上縁前壁に有茎性腫瘤を触知した.大腸内視鏡検査では歯状線口側に約50mm大の粘膜下腫瘤を認め,超音波内視鏡では粘膜下層由来の腫瘍が疑われ,Boring生検で神経鞘腫と診断された.CTでは内部にまだらな造影効果を認め,MRIではT2強調で高信号,不均一な造影効果を有する有茎性腫瘍として描出された.手術待機期間中に腫瘍が肛門から脱出し,救急外来にて用手的に還納を行った.治療は腰椎麻酔下にジャックナイフ位で経肛門的切除術を施行した.切除標本の病理組織診断では,悪性所見のない神経鞘腫で断端は陰性であった.直腸神経鞘腫は稀な疾患であるが悪性例の報告もあり,また生検だけでは良悪性の鑑別は困難とされているため,文献的考察を加え報告する.(著者抄録)
  • 井上 賢之, 堀江 久永, 佐田友 藍, 清水 徹一郎, 田原 真紀子, 直井 大志, 森 和亮, 巷野 佳彦, 伊藤 誉, 森本 光昭, 鯉沼 広治, 宮倉 安幸, 佐田 尚宏  自治医科大学紀要  39-  15  -21  2017/03  [Not refereed][Not invited]
     
    左側大腸癌イレウス治療における経肛門イレウス管の適応と限界について後方視的に検討した。2006〜2011年に当科で手術治療を施行した左側大腸癌イレウス59症例を経肛門イレウス管減圧群(DC群)と非減圧群(NDC群)の2群に分け治療成績を比較した。イレウス管留置成功率は89%であった。DC群25例中、一期的切除吻合術が施行できたのは13例(52%)のみであった。7例(28%)では減圧したにも関わらずストマ造設のみ施行されており、原因として減圧不良(4例)、血清アルブミン低値(3例)、骨盤内他臓器浸潤(2例)があげられた。一期的切除吻合を目的とした経肛門イレウス管挿入は遠隔転移や高度局所浸潤がなく栄養状態良好症例には良い適応と考えられた。一方、栄養状態不良症例には術前経口摂取が可能となるステント挿入を、遠隔転移や高度局所浸潤症例に対してはストマ造設を選択すべきと考えられた。(著者抄録)
  • 佐田尚宏, 齋藤晶, 木村有希, 青木裕一, 田口昌延, 笠原尚哉, 森嶋計, 三木厚, 兼田裕司, 遠藤和洋, 小泉大, 笹沼英紀, 佐久間康成, 栗原克己, 大木準, 鈴木正徳  胆とすい  38-  (2)  195‐199  2017/02  [Not refereed][Not invited]
  • 巷野 佳彦, 堀江 久永, 直井 大志, 佐田友 藍, 伊藤 誉, 森本 光昭, 田原 真紀子, 井上 賢之, 鯉沼 広治, 佐田 尚宏  癌の臨床  63-  (1)  7  -12  2017/02  [Not refereed][Not invited]
     
    クリニカルパスを用いて周術期管理を行った直腸癌前方切除症例94例を対象とし、以前のクリニカルパスで周術期管理を行った40例(男性21名、女性19名、65±10歳;5日目食事開始パス群)と経口摂取を早めたクリニカルパスで周術期管理を行った54例(男性33名、女性21名、61±12歳;2日目食事開始パス群)に分けた。手術に関しては、2日目食事開始パス群で腹腔鏡の手術の割合が増加した