souda kuniyasu

FacultyClinicalLaboratoriesforCardiovascularDiseases
Job titleProfessorWeb site

Profile

Research Keywords

    polyamine, spermine, lifespan extension, gene methylation, anti-aging, cancer inhibition, cancer cachexia, Surgery in General, Gastroenterological Surgery

Research Areas

  • Basic medicine / Immunology
  • Clinical surgery / General surgery

Career

  • 1989
    -
    1994
    Jichi Medical School, Assistant
  • 1994
    -
    1996
    Jichi Medical School, Assistant Professor
  • 1996
    -
    1997
    The Picower Institute for Medical Research, Study investigator
  • 2001
    - Jichi Medical School, Assistant Professor

Academic Background

  • -
    1980
    Faculty of Medicine, Jichi Medical University (japan)

Research Activities

Papers(paper)

  • The importance of tissue environment surrounding the tumor on the development of cancer cachexia.
    Chiba F, Soda K, Yamada S, Tokutake Y, Chohnan S, Konishi F, Rikiyama T
    International journal of oncology 44 177-186 Jan. 2014
  • Increased polyamine intake inhibits age-associated alteration in global DNA methylation and 1,2-dimethylhydrazine-induced tumorigenesis.
    Soda K, Kano Y, Chiba F, Koizumi K, Miyaki Y
    PloS one 8 e64357 2013
  • Suppression of LFA-1 Expression by spermine is associated with enhanced methylation of ITGAL, the LFA-1 promoter area.
    SODA Kuniyasu
    PLoS ONE 8 e56056 2013
  • Spermine accelerates hypoxia-initiated cancer cell migration.
    SODA Kuniyasu
    Int J Oncol 38 305-312 2011
  • Mediterranean diet and polyamine intake –possible contribution of increased polyamine intake to inhibition of age-associated disease.
    SODA Kuniyasu
    Nutrition and Dietary Supplements 3 1-7 2011
  • Gross domestic product and dietary pattern among 49 Western countries with a focus on polyamine intake.
    SODA Kuniyasu
    Health 2 1327-1334 2010
  • Polyamine intake, dietary pattern, and cardiovascular disease.
    SODA Kuniyasu
    Med Hypotheses 75 299-301 2010
  • Polyamine-rich food decreases age-associated pathology and mortality in aged mice.
    SODA Kuniyasu
    Exp. Gerontology 44 727-732 2009
  • Long-term oral polyamine intake increases blood polyamine concentrations.
    SODA Kuniyasu
    J. Nutr. Sci. Vitaminol. 55 361-366 2009
  • Decrease in malonyl-CoA and its background metabolic alterations in murine model of cancer cachexia.
    SODA Kuniyasu
    Oncology Reports 21 1105-1111 2009
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Papers(paper)close
  • The importance of tissue environment surrounding the tumor on the development of cancer cachexia.
    Chiba F, Soda K, Yamada S, Tokutake Y, Chohnan S, Konishi F, Rikiyama T
    International journal of oncology 44 177-186 Jan. 2014
  • Increased polyamine intake inhibits age-associated alteration in global DNA methylation and 1,2-dimethylhydrazine-induced tumorigenesis.
    Soda K, Kano Y, Chiba F, Koizumi K, Miyaki Y
    PloS one 8 e64357 2013
  • Suppression of LFA-1 Expression by spermine is associated with enhanced methylation of ITGAL, the LFA-1 promoter area.
    SODA Kuniyasu
    PLoS ONE 8 e56056 2013
  • Spermine accelerates hypoxia-initiated cancer cell migration.
    SODA Kuniyasu
    Int J Oncol 38 305-312 2011
  • Mediterranean diet and polyamine intake –possible contribution of increased polyamine intake to inhibition of age-associated disease.
    SODA Kuniyasu
    Nutrition and Dietary Supplements 3 1-7 2011
  • Gross domestic product and dietary pattern among 49 Western countries with a focus on polyamine intake.
    SODA Kuniyasu
    Health 2 1327-1334 2010
  • Polyamine intake, dietary pattern, and cardiovascular disease.
    SODA Kuniyasu
    Med Hypotheses 75 299-301 2010
  • Polyamine-rich food decreases age-associated pathology and mortality in aged mice.
    SODA Kuniyasu
    Exp. Gerontology 44 727-732 2009
  • Long-term oral polyamine intake increases blood polyamine concentrations.
    SODA Kuniyasu
    J. Nutr. Sci. Vitaminol. 55 361-366 2009
  • Decrease in malonyl-CoA and its background metabolic alterations in murine model of cancer cachexia.
    SODA Kuniyasu
    Oncology Reports 21 1105-1111 2009
  • Increased blood spermine levels decrease the cytotoxic activity of lymphokine-activated killer cells: a novel mechanism of cancer evasion.
    SODA Kuniyasu
    Cancer Immunol Immunother 56 771-781 2007
  • Erythropoietin attenuates cachectic events and decreases production of interleukin-6, a cachexia-inducing cytokine.
    Masaki Kanzaki
    Cytokine 32 234-239 2005
  • Spermine, a natural polyamine, suppresses LFA-1 expression on human lymphocyte.
    SODA Kuniyasu
    J. Immunol. 175 237-245 2005
  • Increased Polyamine Intake Inhibits Age-associated Alteration in Global DNA Methylation and 1,2-dimethylhydrazine-induced Tumorigenesis.
    SODA Kuniyasu
    PLoS ONE 8 e64357

Papers(other)

  • Splenctomy Protect the mice from cochectic death (Preliminary Study) : Preliminary report.
    339,93/3 1992
  • Effects of β-glucon (Lentinen) on activity of mice with cancer cachexia
    BIOTHERAPY 6(6) 969-975 1992
  • Characterization of mice bearing subclone of colon 26 adenocarcinoma disqualifies interleukin-6 as the sole inducer of cachexia
    Japanese Journal of Cancer Research 85 1124-1130 1994
  • A newly developed fine-caliber endoscope for peroral cholangiopancreatoscopy
    Endoscopy 26(8) 671-675 1994
  • Cancer cachexia : pathogenesis and possible role of cytokines
    Annals of Cancer Research and Therapy 3(2) 73-81 1994
  • Serum lidocaine and MEGX concentrations after pharyngeal anesthesia for gastroscopy
    Endoscopy 26(4) 347-351 1994
  • Per-oral fine-caliber cholangio-pancreatoscopy (Development for ordinary clinical application)
    Gastroenterological Endoscopy 35(3) 505-510 1993
  • Usefulness of a fine scope for peroral transpapillary cholangioscopy
    Gastroenterological Endoscopy 35(12) 2883-2891 1993
  • Fetuin protects the fetus from TNF
    The Lancet 350 861-862 1997
  • Manifestations of cancer cachexia induced by colon 26 adenocarcinoma are not fully ascribable to interleukin-6
    International Journal of Cancer 62(3) 332-336 1995
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Papers(other)close
  • Splenctomy Protect the mice from cochectic death (Preliminary Study) : Preliminary report.
    339,93/3 1992
  • Effects of β-glucon (Lentinen) on activity of mice with cancer cachexia
    BIOTHERAPY 6(6) 969-975 1992
  • Characterization of mice bearing subclone of colon 26 adenocarcinoma disqualifies interleukin-6 as the sole inducer of cachexia
    Japanese Journal of Cancer Research 85 1124-1130 1994
  • A newly developed fine-caliber endoscope for peroral cholangiopancreatoscopy
    Endoscopy 26(8) 671-675 1994
  • Cancer cachexia : pathogenesis and possible role of cytokines
    Annals of Cancer Research and Therapy 3(2) 73-81 1994
  • Serum lidocaine and MEGX concentrations after pharyngeal anesthesia for gastroscopy
    Endoscopy 26(4) 347-351 1994
  • Per-oral fine-caliber cholangio-pancreatoscopy (Development for ordinary clinical application)
    Gastroenterological Endoscopy 35(3) 505-510 1993
  • Usefulness of a fine scope for peroral transpapillary cholangioscopy
    Gastroenterological Endoscopy 35(12) 2883-2891 1993
  • Fetuin protects the fetus from TNF
    The Lancet 350 861-862 1997
  • Manifestations of cancer cachexia induced by colon 26 adenocarcinoma are not fully ascribable to interleukin-6
    International Journal of Cancer 62(3) 332-336 1995
  • Splenectomy before tumor inoculation prolongs the survival of cachectic mice
    Cancer Immunology Immunotherapy 41(4) 203-209 1995
  • Spermine inhibites proinflammatory cytokine synthesis in human mononuclear cells : a counterregulatory mechanism that restrains the immune response
    Journal of Experimental Medicine 185(10) 1759-1768 1997
  • Peroral cholangioscopy using a new fine-caliber flexible scope for detailed examination without papillotomy
    Gastrointestinal Endoscopy 43(3) 233-238 1996
  • Primary leiomyosarcoma of the lesser sac-report of a case
    Japanese Journal of Surgery 14(6) 505-509 1984
  • A case of minute non-functional malignant islet cell tumor of the pancreas
    Surgery Today 25(5) 444-446 1995

Book

  • The role of cytokines and the effect of modifications of host's immune system on cancer cachexia
    cytokines, cholera, and the gut 1996
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  • The role of cytokines and the effect of modifications of host's immune system on cancer cachexia
    cytokines, cholera, and the gut 1996

Outside Fund Adoption

  • Patho physiology of Cancer Cachexia
  • Control of post-operative immune change
  • Polyamine
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Outside Fund Adoptionclose
  • Patho physiology of Cancer Cachexia
  • Control of post-operative immune change
  • Polyamine


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