watanabe kazuhisa

FacultyDivisionofHumanGenetics
Job titleResearch AssociateWeb site

Profile

Research Areas

  • Basic medicine / Pathological medical chemistry
  • Biological Science / Molecular biology

Academic Societies

  • JAPAN SOCIETY OF NUTRITION AND FOOD SCIENCE
  • JAPAN SOCIETY FOR THE STUDY OF OBESITY
  • THE JAPAN DIABETES SOCIETY
Display all
Academic Societiesclose
  • JAPAN SOCIETY OF NUTRITION AND FOOD SCIENCE
  • JAPAN SOCIETY FOR THE STUDY OF OBESITY
  • THE JAPAN DIABETES SOCIETY

Research Activities

Papers(paper)

  • Effects of a novel MC4R agonist on maintenance of reduced body weight in diet-induced obese mice.
    Skowronski AA, Morabito MV, Mueller BR, Lee S, Hjorth S, Lehmann A, Watanabe K, Zeltser LM, Ravussin Y, Rosenbaum M, Leduc CA, Leibel RL
    Obesity (Silver Spring, Md.) 22(5) 1287-1295 May 2014
  • β-cell dysfunction due to increased ER stress in a stem cell model of Wolfram syndrome.
    Shang L, Hua H, Foo K, Martinez H, Watanabe K, Zimmer M, Kahler DJ, Freeby M, Chung W, LeDuc C, Goland R, Leibel RL, Egli D
    Diabetes 63(3) 923-933 Mar. 2014
  • Molecular basis for the regulation of islet beta cell mass in mice: the role of E-cadherin.
    Wakae-Takada N, Xuan S, Watanabe K, Meda P, Leibel RL
    Diabetologia 56 856-866 Apr. 2013
  • ILDR2: an endoplasmic reticulum resident molecule mediating hepatic lipid homeostasis.
    Watanabe K, Watson E, Cremona ML, Millings EJ, Lefkowitch JH, Fischer SG, LeDuc CA, Leibel RL
    PloS one 8(6) e67234 2013
  • Effects of ambient temperature on adaptive thermogenesis during maintenance of reduced body weight in mice.
    Ravussin Y, LeDuc CA, Watanabe K, Leibel RL
    American journal of physiology. Regulatory, integrative and comparative physiology 303(4) R438-48 Aug. 2012
  • Protein kinase Cbeta mediates hepatic induction of sterol-regulatory element binding protein-1c by insulin.
    Yamamoto T, Watanabe K, Inoue N, Nakagawa Y, Ishigaki N, Matsuzaka T, Takeuchi Y, Kobayashi K, Yatoh S, Takahashi A, Suzuki H, Yahagi N, Gotoda T, Yamada N, Shimano H
    Journal of lipid research 51 1859-1870 Jul. 2010
  • The liver-enriched transcription factor CREBH is nutritionally regulated and activated by fatty acids and PPARalpha.
    Danno H, Ishii KA, Nakagawa Y, Mikami M, Yamamoto T, Yabe S, Furusawa M, Kumadaki S, Watanabe K, Shimizu H, Matsuzaka T, Kobayashi K, Takahashi A, Yatoh S, Suzuki H, Yamada N, Shimano H
    Biochemical and biophysical research communications 391 1222-1227 Jan. 2010
  • SPARC is a major secretory gene expressed and involved in the development of proliferative diabetic retinopathy.
    Watanabe K, Okamoto F, Yokoo T, Iida KT, Suzuki H, Shimano H, Oshika T, Yamada N, Toyoshima H
    Journal of atherosclerosis and thrombosis 16 69-76 Apr. 2009
  • Cyclin-dependent kinase inhibitor, p21WAF1/CIP1, is involved in adipocyte differentiation and hypertrophy, linking to obesity, and insulin resistance.
    Inoue N, Yahagi N, Yamamoto T, Ishikawa M, Watanabe K, Matsuzaka T, Nakagawa Y, Takeuchi Y, Kobayashi K, Takahashi A, Suzuki H, Hasty AH, Toyoshima H, Yamada N, Shimano H
    The Journal of biological chemistry 283 21220-21229 Jul. 2008
  • Identification of ISG12b as a putative interferon-inducible adipocytokine which is highly expressed in white adipose tissue.
    Ohgaki S, Iida K, Yokoo T, Watanabe K, Kihara R, Suzuki H, Shimano H, Toyoshima H, Yamada N
    Journal of atherosclerosis and thrombosis 14 179-184 Aug. 2007
Display all
Papers(paper)close
  • Effects of a novel MC4R agonist on maintenance of reduced body weight in diet-induced obese mice.
    Skowronski AA, Morabito MV, Mueller BR, Lee S, Hjorth S, Lehmann A, Watanabe K, Zeltser LM, Ravussin Y, Rosenbaum M, Leduc CA, Leibel RL
    Obesity (Silver Spring, Md.) 22(5) 1287-1295 May 2014
  • β-cell dysfunction due to increased ER stress in a stem cell model of Wolfram syndrome.
    Shang L, Hua H, Foo K, Martinez H, Watanabe K, Zimmer M, Kahler DJ, Freeby M, Chung W, LeDuc C, Goland R, Leibel RL, Egli D
    Diabetes 63(3) 923-933 Mar. 2014
  • Molecular basis for the regulation of islet beta cell mass in mice: the role of E-cadherin.
    Wakae-Takada N, Xuan S, Watanabe K, Meda P, Leibel RL
    Diabetologia 56 856-866 Apr. 2013
  • ILDR2: an endoplasmic reticulum resident molecule mediating hepatic lipid homeostasis.
    Watanabe K, Watson E, Cremona ML, Millings EJ, Lefkowitch JH, Fischer SG, LeDuc CA, Leibel RL
    PloS one 8(6) e67234 2013
  • Effects of ambient temperature on adaptive thermogenesis during maintenance of reduced body weight in mice.
    Ravussin Y, LeDuc CA, Watanabe K, Leibel RL
    American journal of physiology. Regulatory, integrative and comparative physiology 303(4) R438-48 Aug. 2012
  • Protein kinase Cbeta mediates hepatic induction of sterol-regulatory element binding protein-1c by insulin.
    Yamamoto T, Watanabe K, Inoue N, Nakagawa Y, Ishigaki N, Matsuzaka T, Takeuchi Y, Kobayashi K, Yatoh S, Takahashi A, Suzuki H, Yahagi N, Gotoda T, Yamada N, Shimano H
    Journal of lipid research 51 1859-1870 Jul. 2010
  • The liver-enriched transcription factor CREBH is nutritionally regulated and activated by fatty acids and PPARalpha.
    Danno H, Ishii KA, Nakagawa Y, Mikami M, Yamamoto T, Yabe S, Furusawa M, Kumadaki S, Watanabe K, Shimizu H, Matsuzaka T, Kobayashi K, Takahashi A, Yatoh S, Suzuki H, Yamada N, Shimano H
    Biochemical and biophysical research communications 391 1222-1227 Jan. 2010
  • SPARC is a major secretory gene expressed and involved in the development of proliferative diabetic retinopathy.
    Watanabe K, Okamoto F, Yokoo T, Iida KT, Suzuki H, Shimano H, Oshika T, Yamada N, Toyoshima H
    Journal of atherosclerosis and thrombosis 16 69-76 Apr. 2009
  • Cyclin-dependent kinase inhibitor, p21WAF1/CIP1, is involved in adipocyte differentiation and hypertrophy, linking to obesity, and insulin resistance.
    Inoue N, Yahagi N, Yamamoto T, Ishikawa M, Watanabe K, Matsuzaka T, Nakagawa Y, Takeuchi Y, Kobayashi K, Takahashi A, Suzuki H, Hasty AH, Toyoshima H, Yamada N, Shimano H
    The Journal of biological chemistry 283 21220-21229 Jul. 2008
  • Identification of ISG12b as a putative interferon-inducible adipocytokine which is highly expressed in white adipose tissue.
    Ohgaki S, Iida K, Yokoo T, Watanabe K, Kihara R, Suzuki H, Shimano H, Toyoshima H, Yamada N
    Journal of atherosclerosis and thrombosis 14 179-184 Aug. 2007
  • WGEF is a novel RhoGEF expressed in intestine, liver, heart, and kidney.
    Wang Y, Suzuki H, Yokoo T, Tada-Iida K, Kihara R, Miura M, Watanabe K, Sone H, Shimano H, Toyoshima H, Yamada N
    Biochemical and biophysical research communications 324 1053-1058 Nov. 2004
  • Weight Perturbation Alters Leptin Signal Transduction in a Region-Specific Manner throughout the Brain.
    Morabito MV, Ravussin Y, Mueller BR, Skowronski AA, Watanabe K, Foo KS, Lee SX, Lehmann A, Hjorth S, Zeltser LM, LeDuc CA, Leibel RL
    PloS one 12(1) e0168226 Jan. 2017
  • ZNF70, a novel ILDR2-interacting protein, contributes to the regulation of HES1 gene expression.
    Watanabe K, Nakayama K, Ohta S, Tago K, Boonvisut S, Millings EJ, Fischer SG, LeDuc CA, Leibel RL, Iwamoto S
    Biochemical and biophysical research communications 477(4) 712-716 Sep. 2016
  • Replication analysis of genetic association of the NCAN-CILP2 region with plasma lipid levels and non-alcoholic fatty liver disease in Asian and Pacific ethnic groups.
    Boonvisut S, Nakayama K, Makishima S, Watanabe K, Miyashita H, Lkhagvasuren M, Kagawa Y, Iwamoto S
    Lipids in health and disease 15 8 Jan. 2016
  • The role of TRIB1 in lipid metabolism; from genetics to pathways.
    Iwamoto S, Boonvisut S, Makishima S, Ishizuka Y, Watanabe K, Nakayama K
    Biochemical Society transactions 43(5) 1063-1068 Oct. 2015
  • Sin3A-associated protein, 18 kDa, a novel binding partner of TRIB1, regulates MTTP expression.
    Makishima S, Boonvisut S, Ishizuka Y, Watanabe K, Nakayama K, Iwamoto S
    Journal of lipid research 56(6) 1145-1152 Jun. 2015
  • Common variants of GIP are associated with visceral fat accumulation in Japanese adults.
    Nakayama K, Watanabe K, Boonvisut S, Makishima S, Miyashita H, Iwamoto S
    American journal of physiology. Gastrointestinal and liver physiology 307(11) G1108-14 Dec. 2014


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