Researchers Database

kihara astushi

    DepartmentofPathology,DivisionofIntegrativePathology Assistant Professor
Last Updated :2021/11/24

Researcher Information


Research funding number

  • 10806756


J-Global ID

Research Interests

  • Human Pathology   Diagnostic Pathology   Gynecological Pathology   Immunohistochemistry   

Research Areas

  • Life sciences / Human pathology

Academic & Professional Experience

  • 2017/04 - Today  Jichi Medical UniversityDepartment of Pathology

Association Memberships

  • Japanese Division of International Academy of Pathology   The Japanese Society of Clinical Cytology   THE JAPANESE CANCER ASSOCIATION   The Japanese Society of Pathology   

Published Papers

Conference Activities & Talks

  • SMARCA4 and SMARCB1 expression in uterine mesenchymal tumors  [Not invited]
    The 110th anual meeting of the Japanese Society of Pathology  2021/04
  • Immunohistochemical analysis of SWI/SNF complex subunits expression in endometrial carcinomas
    第109回日本病理学会総会(Web)  2020/07
  • Immunohistochemical analysis of stromal component of atypical polypoid adenomyoma  [Not invited]
    Kihara Atsushi
    The 108th annual meeting of the Japanese society of pathology  2019/05
  • Expression of SNAIL and SLUG in high-grade endometrial carcinomas  [Not invited]
    The 105th annual meeting of the Japanese society of pathology  2016/05
  • Glomus tumor of the liver presenting as a cystic lesion  [Not invited]
    The 101th annual meeting of the Japanese society of pathology  2012/04
  • A case of plasma cell leukemia presenting pleural effusion as a first symptom  [Not invited]
    第52回日本臨床細胞学会総会(春期大会)  2011/05  Fukuoka, Japan
  • A case of well-differentiated fetal adenocarcinoma of the lung  [Not invited]
    The 49th fall meeting of Japanese society of clinical cytology  2010/11
  • 再発性多発軟骨炎に対するステロイド・免疫抑制剤投与中にHSVによる劇症肝炎と全身感染を発症した1剖検例  [Not invited]
    The 99th annual meeting of the Japanese society of pathology  2010/04
  • 肺結節病変に対するDynamic MRIによる良悪性の鑑別能  [Not invited]
    The 49th Annual Meeting of the Japanese Respiratory Society  2009/06
  • カルバマゼピンで重篤な好酸球性肺炎と紅皮症を呈した1例  [Not invited]
    日本内科学会関東地方会  2008/06
  • 上行大動脈置換術後の経過観察中に弓部大動脈瘤が認められ、症状発症から約2日後に診断されたaorto-pulmonary fistulaの一例  [Not invited]
    日本救急医学会中部地方会  2006/11


  • Ryoichi Miyamoto, Katsumi Amikura, Shinichi Matsudaira, Hiroyuki Ishida, Toshiro Ogura, Amane Takahashi, Atsushi Kihara, Hiroaki Kanda, Yoshiyuki Kawashima  Surgical Case Reports  7-  (1)  2021/12
  • Yuichi Aoki, Hideki Sasanuma, Yuki Kimura, Akira Saito, Kazue Morishima, Yuji Kaneda, Kazuhiro Endo, Atsushi Yoshida, Atsushi Kihara, Yasunaru Sakuma, Hisanaga Horie, Yoshinori Hosoya, Alan Kawarai Lefor, Naohiro Sata  The Journal of international medical research  48-  (10)  300060520962967  -300060520962967  2020/10  [Refereed]
  • Yoshiyuki Inoue, Hisanaga Horie, Yuko Homma, Ai Sadatomo, Makiko Tahara, Koji Koinuma, Hironori Yamaguchi, Toshiki Mimura, Atsushi Kihara, Alan Kawarai Lefor, Naohiro Sata  Surgical case reports  6-  (1)  174  -174  2020/07  [Refereed][Not invited]
  • Daisuke Matsubara, Taichiro Yoshimoto, Manabu Soda, Yusuke Amano, Atsushi Kihara, Toko Funaki, Takeshi Ito, Yuji Sakuma, Tomoki Shibano, Shunsuke Endo, Koichi Hagiwara, Shumpei Ishikawa, Masashi Fukayama, Yoshinori Murakami, Hiroyuki Mano, Toshiro Niki  Cancer science  111-  (6)  2183  -2195  2020/06  [Refereed][Not invited]
  • Katsushi Suenaga, Shiro Matsumoto, Alan Kawarai Lefor, Yoshimasa Miura, Yoshinori Hosoya, Daigo Kuboki, Hidenori Haruta, Kentaro Kurashina, Atsushi Kihara, Daisuke Matsubara, Yasunari Sakuma, Joji Kitayama, Naohiro Sata  International journal of surgery case reports  73-  319  -323  2020  [Refereed][Not invited]
    INTRODUCTION: Gastric adenocarcinomas with low grade atypia may be difficult to diagnose as gastric cancer by preoperative biopsy. We report an extremely well-differentiated adenocarcinoma (EWDA) of the stomach which appeared like a submucosal tumor diagnosed by preoperative endoscopic submucosal dissection. PRESENTATION OF CASE: A 70-year-old male was referred with a 3-month history of a submucosal-appearing lesion in the gastric wall found on endoscopy. Biopsies of the lesion were performed and were inconclusive for neoplasia. Endoscopic ultrasonography showed a low echoic tumor growing into the fourth layer of the gastric wall. It was difficult to identify the tumor by repeat biopsy. Endoscopic submucosal dissection of the lesion was performed and revealed adenocarcinoma, and laparoscopic total gastrectomy was performed. Histopathologic evaluation showed that the tumor was stage IIA (T3N0M0). There is no recurrence 12 months after resection. DISCUSSION: Gastric EWDAs are rare lesions, accounting for 0.6% of all gastric cancers. It is difficult to diagnose gastric EWDA especially if it appears like a submucosal tumor. This lesion was finally diagnosed by endoscopic submucosal dissection. CONCLUSION: Endoscopic submucosal dissection may facilitate establishing the preoperative diagnosis of a tumor thought to be a gastric EWDA based on its endoscopic appearance and pathological findings.
  • Taichiro Yoshimoto, Daisuke Matsubara, Manabu Soda, Toshihide Ueno, Yusuke Amano, Atsushi Kihara, Takashi Sakatani, Tomoyuki Nakano, Tomoki Shibano, Shunsuke Endo, Koichi Hagiwara, Masashi Fukayama, Kaori Denda-Nagai, Tatsuro Irimura, Hiroyuki Mano, Toshiro Niki  Cancer science  110-  (9)  3006  -3011  2019/09  [Refereed][Not invited]
    Decreased cell adhesion has been reported as a significant negative prognostic factor of lung cancer. However, the molecular mechanisms responsible for the cell incohesiveness in lung cancer have not yet been elucidated in detail. We herein describe a rare histological variant of lung adenocarcinoma consisting almost entirely of individual cancer cells spreading in alveolar spaces in an incohesive pattern. A whole exome analysis of this case showed no genomic abnormalities in CDH1 or other genes encoding cell adhesion molecules. However, whole mRNA sequencing revealed that this case had an extremely high expression level of mucin 21 (MUC21), a mucin molecule that was previously shown to inhibit cell-cell and cell-matrix adhesion. The strong membranous expression of MUC21 was found on cancer cells using mAbs recognizing different O-glycosylated forms of MUC21. An immunohistochemical analysis of an unselected series of lung adenocarcinoma confirmed that the strong membranous expression of MUC21 correlated with incohesiveness. Thus, MUC21 could be a promising biomarker with potential diagnostic and therapeutic applications for lung adenocarcinoma showing cell incohesiveness.
  • Rie Kurashige, Hiroyuki Sakashita, Seishi Higashi, Ken Uchibori, Atsushi Kihara, Naohiko Inase  Japanese Journal of Lung Cancer  56-  (4)  308  -313  2016/08  [Refereed][Not invited]
    Background. Two ALK inhibitors are available for the treatment of lung cancer in Japan, but resistance to both is not uncommon. Case. A 37-year-old female was diagnosed with ALK-rearrangement-positive lung adenocarcinoma at cT2aN3M0, stage IIIB. She was initially treated with alectinib and showed a sustained partial response (PR) for four and a half months. She was then switched from alectinib to cisplatin and pemetrexed due to progressive disease (PD). On the 16th day of the second drug regimen she developed fever, elevated C-reactive protein levels, and rapidly enlarged lymph nodes. Re-treatment with alectinib attenuated her liver metastasis and partially reduced her lymph node enlargement, but several other lymph nodes continued to grow. The alectinib was then switched to crizotinib, which elicited a PR. A re-biopsied sample of the right supraclavicular lymph node tested positive for ALK-rearrangement by immunohistochemistry and fluorescence in situ hybridization analyses and included some MET-positive cells. We diagnosed adenocarcinoma based on the histological findings which were very similar to the findings we observed in the first examination. Conclusion. The patient's disease responded with a flare-like reaction after the alectinib was discontinued. The MET amplification observed after the alectinib was re-administered might have been related to a resistance mechanism in the growing tumor. Further research on ALK inhibitor resistance is therefore warranted.
  • Takaaki Mase, Atsushi Kihara, Kenshiro Arao  European heart journal  36-  (44)  3048  -3048  2015/11  [Refereed][Not invited]
  • 両側副腎のprimary pigmented nodular adrenocortical diseaseからCarney complexの診断に到った2例
    土井 紀輝, 橋本 浩次, 郡司 真理子, 木原 淳, 福島 純一, 堀内 啓  診断病理  31-  (1)  47  -51  2014/01  [Refereed][Not invited]
  • Shiro Satoh, Shuichiro Nakaminato, Atsushi Kihara, Susumu Isogai, Shigeo Kawai  Magnetic resonance in medical sciences : MRMS : an official journal of Japan Society of Magnetic Resonance in Medicine  12-  (1)  31  -8  2013/03  [Refereed][Not invited]
    PURPOSE: We prospectively assessed whether enhancement characteristics on dynamic magnetic resonance (MR) imaging could distinguish indeterminate pulmonary nodules. METHODS: We evaluated 51 pulmonary nodules in 51 consecutive patients (11 female, 40 male; mean age, 64 years) using dynamic MR images acquired at 0, 10, 20, 30, 40, 50, 60, 70, 80, 90, 120, 150, 180, 210, 240, 360, 480, 600, 720, and 840 s following injection of contrast material. We prospectively evaluated morphologic enhancement patterns, peak rate, time to peak enhancement, steepest slope, and washout of nodules and analyzed statistics to determine any differences between MR parameters, patient age, tumor size, and final diagnosis. RESULTS: We found 25 malignant, 12 active inflammatory, and 14 benign nodules. Nodule diameter was significantly larger for malignant than nonmalignant, and benign nodules (P≤0.01). Patients with malignant nodules were significantly older than those with nonmalignant (P=0.01) and active inflammatory (P=0.02) nodules. However, morphologic enhancement patterns, peak rate, time to peak enhancement, steepest slope, and washout characteristics at 2, 4, 8, and 12 min showed no significant difference between malignant and nonmalignant nodules and among malignant, active inflammatory, and benign nodules. CONCLUSION: Prospective assessment of dynamic MR images demonstrated their inadequacy for distinguishing indeterminate pulmonary nodules.
  • Kenya Kobayashi, Kazunari Nakao, Sadahiro Kishishita, Noriko Tamaruya, Hiroko Monobe, Ken'ichi Saito, Atsushi Kihara  Auris, nasus, larynx  40-  (1)  89  -92  2013/02  [Refereed][Not invited]
    OBJECTIVE: Vascular malformations may appear anywhere in the body; 14-65% are in the head and neck. There are several treatments (sclerotherapy, surgery, laser treatment, and embolization, etc.), but standardized guidelines for these treatments are lacking. We conducted a retrospective review of venous or capillary malformations of the head and neck, and analyzed the epidemiology, pathology and treatment. METHODS: We retrospectively reviewed 67 patients with pathologically diagnosed venous or capillary malformations of the head and neck; we analyzed the location, pathology and treatment, as well as recurrent/residual cases. RESULTS: The oral cavity (59%) and nasal cavity (35%) were the most common locations. The frequency of each pathological type depended upon location. Surgery was undertaken in 65 cases, and sclerotherapy done in one patient. Sixty-one cases (92%) had resectable lesions. However polycystic masses (≥3 cysts) and large masses (diameter, ≥5cm) were significantly difficult to cure by single treatment. CONCLUSIONS: Surgery is indicated for localized small vascular malformations. However if the lesions ≥5cm or polycystic lesions were more likely to recur after surgery alone in our study population.
  • Tetsuro Sameshima, Keita Shibahashi, Toshiki Nozaki, Atsuya Akabane, Atsushi Kihara, Hajime Horiuchi, Akio Morita  Neurologia medico-chirurgica  53-  (2)  125  -8  2013  [Refereed][Not invited]
    A 69-year-old man presented with progressive paralysis of the right arm and leg with a past history of metastatic rectal cancer. Magnetic resonance imaging showed a cystic mass lesion posterior to the odontoid process. Under a preoperative diagnosis of intradural extramedullary tumor, partial transcondylectomy and C1 hemilaminectomy were performed, and the cyst was removed through a transdural approach, decompressing the medulla oblongata and the cervical spinal cord. The histological diagnosis was juxtafacet cyst (ganglion cyst). An atlantoaxial intraspinal juxtafacet cyst at the level of the odontoid process is extremely rare. In our case, the cyst was removed using a posterior approach, resulting in rapid improvement in symptoms.
  • Takahiko Nakajima, Nobuyuki Matsuhashi, Satoshi Nara, Atsushi Nakajima, Johji Imura, Atsushi Kihara, Kenichiro Murata, Junichi Fukushima, Hajime Horiuchi  Pathology international  62-  (8)  554  -8  2012/08  [Refereed][Not invited]
    We report an adult case of midgut volvulus in familial visceral myopathy (FVM) that had affected family members over three generations. The patient was a Japanese woman in her fifties, who had chronic intestinal pseudo-obstruction (CIPO) since the age of about 40 years and had been treated chronically with conservative therapies. Her abdominal symptoms suddenly worsened and surgery became necessary. Surgery revealed a midgut volvulus secondary to intestinal malrotation and the twisted intestine was resected. Histology revealed diffuse damage of myocytes confined to the muscularis propria throughout the resected intestine. The myocytes were irregulary arranged, contained cytoplasmic inclusions, and had mild and focal vacuolar changes. The mucsularis propria showed hypertrophy with delicate interstitial fibrosis. A diagnosis of FVM was made on the basis of this characteristic myopathy. Intestinal malrotation is known to be a complication of CIPO in children, but is rare in adults. Although midgut volvulus appears to be extremely rare, it can occur after a relatively stable chronic phase in adult CIPO patients, who should be monitored carefully to assess the risk of such complications.
  • 分類不能の卵巣癌の一例
    飯原 久仁子, 木原 淳, 堀内 啓  日本婦人科病理学会誌  3-  (1)  25  -27  2012/06  [Not refereed][Not invited]
  • Takahiko Nakajima, Tomonori Ushijima, Atsushi Kihara, Kenichiro Murata, Toshiro Sugiyama, Koichi Tsuneyama, Johji Imura, Junichi Fukushima, Hajime Horiuchi  Case reports in gastrointestinal medicine  2012-  606832  -606832  2012  [Refereed][Not invited]
    We report a case of a gastrointestinal stromal tumor (GIST) of the stomach that demonstrated a stepwise progression from low- to high-grade malignancy. The patient had been followed for a small gastric submucosal tumor that had turned malignant after 8 years of indolence, manifested by tarry stools. The tumor was enucleated, and gastric GIST was diagnosed. The most significant histological finding was that the tumor comprised two clearly demarcated areas, one with less aggressive characteristics and the other with highly aggressive characteristics. The patient exhibited multiple liver metastases 24 months after surgery. Imatinib mesylate was not administered throughout the clinical course because it was not available for clinical use at that time. The patient followed an unfavorable clinical course and died of liver dysfunction 55 months after surgery. Autopsy was performed. By comparing the immunohistochemical profiles of primary and metastatic tumors, it was established that only the tumor cells with highly aggressive characteristics had metastasized.
  • 【GIST 診断・治療の進歩】GISTのリスク分類
    中嶋 隆彦, 木原 淳, 田島 将吾, 村田 建一郎, 松谷 章司, 堀内 啓, 杉山 敏郎  臨床消化器内科  25-  (6)  663  -668  2010/05  
    従来gastrointestinal stromal tumor(GIST)においては,腫瘍径と核分裂数を指標とする悪性度分類が広く世界的に用いられてきた.近年,術後補助療法としてのイマチニブの有効性が明らかとされたが,その対象の決定には再発率を含めた正確な悪性度評価(分類)が必要とされる.腫瘍径と核分裂数に加え発生部位を考慮した新しい悪性度分類では,腫瘍径と核分裂数が同等であっても胃以外の原発例では悪性度が高いことが明記された.新たな悪性度分類についてのわが国の成績は不十分で,今後の重要な課題である.(著者抄録)

Awards & Honors

  • 2020/11 Jichi Medical University Valuable paper award 2020, Jichi Medical University
     Stromal p16 expression helps distinguish atypical polypoid adenomyoma from myoinvasive endometrioid carcinoma of the uterus
  • 2018 The international academy of pathology Japanese division Young Investigator Award
     Clinicopathologic association and prognostic value of microcystic, elongated, and fragmented (MELF) pattern in endometrial endometrioid carcinoma

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