tominaga kaoru

FacultyDoctorCourse,ProgramsofHumanBiology,DivisionofBiomolecularmedicine,Biochemistry
Job titleAssociate ProfessorWeb site

Profile

Research Keywords

    cellular senescence, chromatin, stem cell, histone modification, aging, cancer, C3H, IL-6

Research Areas

  • Genome science / Genome biology
  • Laboratory animal science / Laboratory animal science
  • Oncology / Tumor biology
  • Biological Science / Cell biology
  • Basic medicine / General medical chemistry

Research Activities

Papers(paper)

  • Paraneoplastic cerebellar degeneration associated with an onconeural antibody against creatine kinase, brain-type.
    Tetsuka S, Tominaga K, Ohta E, Kuroiwa K, Sakashita E, Kasashima K, Hamamoto T, Namekawa M, Morita M, Natsui S, Morita T, Tanaka K, Takiyama Y, Nakano I, Endo H
    Journal of the neurological sciences 335 48-57 Dec. 2013
  • [Paraneoplastic cerebellar degeneration with bladder cancer confirmed the existence of an anti-neural antibody: a case report].
    Kawanishi K, Morita M, Nakahara K, Tetsuka S, Kouki T, Tominaga K, Endo H, Yashiro T, Tanaka K, Nakano I
    Brain and nerve = Shinkei kenkyu no shinpo 65 1401-1405 Nov. 2013
  • Translational repression of the McKusick-Kaufman syndrome transcript by unique upstream open reading frames encoding mitochondrial proteins with alternative polyadenylation sites.
    Akimoto C, Sakashita E, Kasashima K, Kuroiwa K, Tominaga K, Hamamoto T, Endo H
    Biochimica et biophysica acta 1830 2728-2738 Mar. 2013
  • The role of chromatin reorganization in the process of cellular senescence.
    Tominaga K, Pereira-Smith OM
    Current drug targets 13 1593-1602 Dec. 2012
  • Thioredoxin 1 overexpression extends mainly the earlier part of life span in mice.
    Pérez VI, Cortez LA, Lew CM, Rodriguez M, Webb CR, Van Remmen H, Chaudhuri A, Qi W, Lee S, Bokov A, Fok W, Jones D, Richardson A, Yodoi J, Zhang Y, Tominaga K, Hubbard GB, Ikeno Y
    The journals of gerontology. Series A, Biological sciences and medical sciences 66 1286-1299 Dec. 2011
  • MRG15 activates the cdc2 promoter via histone acetylation in human cells.
    Peña AN, Tominaga K, Pereira-Smith OM
    Experimental cell research 317 1534-1540 Jul. 2011
  • Loss of the chromatin regulator MRG15 limits neural stem/progenitor cell proliferation via increased expression of the p21 Cdk inhibitor.
    Chen M, Pereira-Smith OM, Tominaga K
    Stem cell research 7 75-88 Jul. 2011
  • Exploring the link between MORF4L1 and risk of breast cancer.
    Martrat G, Maxwell CM, Tominaga E, Porta-de-la-Riva M, Bonifaci N, Gómez-Baldó L, Bogliolo M, Lázaro C, Blanco I, Brunet J, Aguilar H, Fernández-Rodríguez J, Seal S, Renwick A, Rahman N, Kühl J, Neveling K, Schindler D, Ramírez MJ, Castellà M, Hernández G, EMBRACE, Easton DF, Peock S, Cook M, Oliver CT, Frost D, Platte R, Evans DG, Lalloo F, Eeles R, Izatt L, Chu C, Davidson R, Ong KR, Cook J, Douglas F, Hodgson S, Brewer C, Morrison PJ, Porteous M, Peterlongo P, Manoukian S, Peissel B, Zaffaroni D, Roversi G, Barile M, Viel A, Pasini B, Ottini L, Putignano AL, Savarese A, Bernard L, Radice P, Healey S, Spurdle A, Chen X, Beesley J, kConFab, Rookus MA, Verhoef S, Tilanus-Linthorst MA, Vreeswijk MP, Asperen CJ, Bodmer D, Ausems MG, van Os TA, Blok MJ, Meijers-Heijboer HE, Hogervorst FB, HEBON, Goldgar DE, Buys S, John EM, Miron A, Southey M, Daly MB, BCFR, SWE-BRCA, Harbst K, Borg A, Rantala J, Barbany-Bustinza G, Ehrencrona H, Stenmark-Askmalm M, Kaufman B, Laitman Y, Milgrom R, Friedman E, Domchek SM, Nathanson KL, Rebbeck TR, Johannsson OT, Couch FJ, Wang X, Fredericksen Z, Cuadras D, Moreno V, Pientka FK, Depping R, Caldés T, Osorio A, Benítez J, Bueren J, Heikkinen T, Nevanlinna H, Hamann U, Torres D, Caligo MA, Godwin AK, Imyanitov EN, Janavicius R, GEMO Study Collaborators, Sinilnikova OM, Stoppa-Lyonnet D, Mazoyer S, Verny-Pierre C, Castera L, de Pauw A, Bignon YJ, Uhrhammer N, Peyrat JP, Vennin P, Ferrer SF, Collonge-Rame MA, Mortemousque I, McGuffog L, Chenevix-Trench G, Pereira-Smith OM, Antoniou AC, Cerón J, Tominaga K, Surrallés J, Pujana MA
    Breast cancer research : BCR 13 R40 Apr. 2011
  • The anti-tumor effects of calorie restriction are correlated with reduced oxidative stress in ENU-induced gliomas.
    Mahlke MA, Cortez LA, Ortiz MA, Rodriguez M, Uchida K, Shigenaga MK, Lee S, Zhang Y, Tominaga K, Hubbard GB, Ikeno Y
    Pathobiology of aging & age related diseases 1 2011
  • Conditional inactivation of MRG15 gene function limits survival during larval and adult stages of Drosophila melanogaster.
    Zhang H, Li Y, Yang J, Tominaga K, Pereira-Smith OM, Tower J
    Experimental gerontology 45 825-833 Nov. 2010
Display all
Papers(paper)close
  • Paraneoplastic cerebellar degeneration associated with an onconeural antibody against creatine kinase, brain-type.
    Tetsuka S, Tominaga K, Ohta E, Kuroiwa K, Sakashita E, Kasashima K, Hamamoto T, Namekawa M, Morita M, Natsui S, Morita T, Tanaka K, Takiyama Y, Nakano I, Endo H
    Journal of the neurological sciences 335 48-57 Dec. 2013
  • [Paraneoplastic cerebellar degeneration with bladder cancer confirmed the existence of an anti-neural antibody: a case report].
    Kawanishi K, Morita M, Nakahara K, Tetsuka S, Kouki T, Tominaga K, Endo H, Yashiro T, Tanaka K, Nakano I
    Brain and nerve = Shinkei kenkyu no shinpo 65 1401-1405 Nov. 2013
  • Translational repression of the McKusick-Kaufman syndrome transcript by unique upstream open reading frames encoding mitochondrial proteins with alternative polyadenylation sites.
    Akimoto C, Sakashita E, Kasashima K, Kuroiwa K, Tominaga K, Hamamoto T, Endo H
    Biochimica et biophysica acta 1830 2728-2738 Mar. 2013
  • The role of chromatin reorganization in the process of cellular senescence.
    Tominaga K, Pereira-Smith OM
    Current drug targets 13 1593-1602 Dec. 2012
  • Thioredoxin 1 overexpression extends mainly the earlier part of life span in mice.
    Pérez VI, Cortez LA, Lew CM, Rodriguez M, Webb CR, Van Remmen H, Chaudhuri A, Qi W, Lee S, Bokov A, Fok W, Jones D, Richardson A, Yodoi J, Zhang Y, Tominaga K, Hubbard GB, Ikeno Y
    The journals of gerontology. Series A, Biological sciences and medical sciences 66 1286-1299 Dec. 2011
  • MRG15 activates the cdc2 promoter via histone acetylation in human cells.
    Peña AN, Tominaga K, Pereira-Smith OM
    Experimental cell research 317 1534-1540 Jul. 2011
  • Loss of the chromatin regulator MRG15 limits neural stem/progenitor cell proliferation via increased expression of the p21 Cdk inhibitor.
    Chen M, Pereira-Smith OM, Tominaga K
    Stem cell research 7 75-88 Jul. 2011
  • Exploring the link between MORF4L1 and risk of breast cancer.
    Martrat G, Maxwell CM, Tominaga E, Porta-de-la-Riva M, Bonifaci N, Gómez-Baldó L, Bogliolo M, Lázaro C, Blanco I, Brunet J, Aguilar H, Fernández-Rodríguez J, Seal S, Renwick A, Rahman N, Kühl J, Neveling K, Schindler D, Ramírez MJ, Castellà M, Hernández G, EMBRACE, Easton DF, Peock S, Cook M, Oliver CT, Frost D, Platte R, Evans DG, Lalloo F, Eeles R, Izatt L, Chu C, Davidson R, Ong KR, Cook J, Douglas F, Hodgson S, Brewer C, Morrison PJ, Porteous M, Peterlongo P, Manoukian S, Peissel B, Zaffaroni D, Roversi G, Barile M, Viel A, Pasini B, Ottini L, Putignano AL, Savarese A, Bernard L, Radice P, Healey S, Spurdle A, Chen X, Beesley J, kConFab, Rookus MA, Verhoef S, Tilanus-Linthorst MA, Vreeswijk MP, Asperen CJ, Bodmer D, Ausems MG, van Os TA, Blok MJ, Meijers-Heijboer HE, Hogervorst FB, HEBON, Goldgar DE, Buys S, John EM, Miron A, Southey M, Daly MB, BCFR, SWE-BRCA, Harbst K, Borg A, Rantala J, Barbany-Bustinza G, Ehrencrona H, Stenmark-Askmalm M, Kaufman B, Laitman Y, Milgrom R, Friedman E, Domchek SM, Nathanson KL, Rebbeck TR, Johannsson OT, Couch FJ, Wang X, Fredericksen Z, Cuadras D, Moreno V, Pientka FK, Depping R, Caldés T, Osorio A, Benítez J, Bueren J, Heikkinen T, Nevanlinna H, Hamann U, Torres D, Caligo MA, Godwin AK, Imyanitov EN, Janavicius R, GEMO Study Collaborators, Sinilnikova OM, Stoppa-Lyonnet D, Mazoyer S, Verny-Pierre C, Castera L, de Pauw A, Bignon YJ, Uhrhammer N, Peyrat JP, Vennin P, Ferrer SF, Collonge-Rame MA, Mortemousque I, McGuffog L, Chenevix-Trench G, Pereira-Smith OM, Antoniou AC, Cerón J, Tominaga K, Surrallés J, Pujana MA
    Breast cancer research : BCR 13 R40 Apr. 2011
  • The anti-tumor effects of calorie restriction are correlated with reduced oxidative stress in ENU-induced gliomas.
    Mahlke MA, Cortez LA, Ortiz MA, Rodriguez M, Uchida K, Shigenaga MK, Lee S, Zhang Y, Tominaga K, Hubbard GB, Ikeno Y
    Pathobiology of aging & age related diseases 1 2011
  • Conditional inactivation of MRG15 gene function limits survival during larval and adult stages of Drosophila melanogaster.
    Zhang H, Li Y, Yang J, Tominaga K, Pereira-Smith OM, Tower J
    Experimental gerontology 45 825-833 Nov. 2010
  • Emerging role of the MORF/MRG gene family in various biological processes, including aging.
    Chen M, Tominaga K, Pereira-Smith OM
    Annals of the New York Academy of Sciences 1197 134-141 Jun. 2010
  • Regulation of alternative splicing by histone modifications.
    Luco RF, Pan Q, Tominaga K, Blencowe BJ, Pereira-Smith OM, Misteli T
    Science (New York, N.Y.) 327 996-1000 Feb. 2010
  • The cell senescence inducing gene product MORF4 is regulated by degradation via the ubiquitin/proteasome pathway.
    Tominaga K, Tominaga E, Ausserlechner MJ, Pereira-Smith OM
    Experimental cell research 316 92-102 Jan. 2010
  • Activation of innate immune antiviral responses by Nod2.
    Sabbah A, Chang TH, Harnack R, Frohlich V, Tominaga K, Dube PH, Xiang Y, Bose S
    Nature immunology 10 1073-1080 Oct. 2009
  • MRG15, a component of HAT and HDAC complexes, is essential for proliferation and differentiation of neural precursor cells.
    Chen M, Takano-Maruyama M, Pereira-Smith OM, Gaufo GO, Tominaga K
    Journal of neuroscience research 87 1522-1531 May 2009
  • Mrg15 null and heterozygous mouse embryonic fibroblasts exhibit DNA-repair defects post exposure to gamma ionizing radiation.
    Garcia SN, Kirtane BM, Podlutsky AJ, Pereira-Smith OM, Tominaga K
    FEBS letters 581 5275-5281 Nov. 2007
  • Multipurpose MRG domain involved in cell senescence and proliferation exhibits structural homology to a DNA-interacting domain.
    Bowman BR, Moure CM, Kirtane BM, Welschhans RL, Tominaga K, Pereira-Smith OM, Quiocho FA
    Structure (London, England : 1993) 14 151-158 Jan. 2006
  • MrgX is not essential for cell growth and development in the mouse.
    Tominaga K, Matzuk MM, Pereira-Smith OM
    Molecular and cellular biology 25 4873-4880 Jun. 2005
  • MRG15 regulates embryonic development and cell proliferation.
    Tominaga K, Kirtane B, Jackson JG, Ikeno Y, Ikeda T, Hawks C, Smith JR, Matzuk MM, Pereira-Smith OM
    Molecular and cellular biology 25 2924-2937 Apr. 2005
  • PAM14, a novel MRG- and Rb-associated protein, is not required for development and T-cell function in mice.
    Tominaga K, Magee DM, Matzuk MM, Pereira-Smith OM
    Molecular and cellular biology 24 8366-8373 Oct. 2004
  • MRGX is a novel transcriptional regulator that exhibits activation or repression of the B-myb promoter in a cell type-dependent manner.
    Tominaga K, Leung JK, Rookard P, Echigo J, Smith JR, Pereira-Smith OM
    The Journal of biological chemistry 278 49618-49624 Dec. 2003
  • The genomic organization, promoter position and expression profile of the mouse MRG15 gene.
    Tominaga K, Pereira-Smith OM
    Gene 294 215-224 Jul. 2002
  • Genetics of cellular senescence.
    Tominaga K, Olgun A, Smith JR, Pereira-Smith OM
    Mechanisms of ageing and development 123 927-936 Apr. 2002
  • Aberrant cell cycle checkpoint function and early embryonic death in Chk1(-/-) mice.
    Takai H, Tominaga K, Motoyama N, Minamishima YA, Nagahama H, Tsukiyama T, Ikeda K, Nakayama K, Nakanishi M, Nakayama K
    Genes & development 14 1439-1447 Jun. 2000
  • Important role of membrane-associated CD14 in the induction of IFN-beta and subsequent nitric oxide production by murine macrophages in response to bacterial lipopolysaccharide.
    Saito S, Matsuura M, Tominaga K, Kirikae T, Nakano M
    European journal of biochemistry / FEBS 267 37-45 Jan. 2000
  • Role of IFN-gamma on dissociation between nitric oxide and TNF/IL-6 production by murine peritoneal cells after restimulation with bacterial lipopolysaccharide.
    Tominaga K, Saito S, Matsuura M, Funatogawa K, Matsumura H, Nakano M
    Journal of leukocyte biology 66 974-980 Dec. 1999
  • Role of human Cds1 (Chk2) kinase in DNA damage checkpoint and its regulation by p53.
    Tominaga K, Morisaki H, Kaneko Y, Fujimoto A, Tanaka T, Ohtsubo M, Hirai M, Okayama H, Ikeda K, Nakanishi M
    The Journal of biological chemistry 274 31463-31467 Oct. 1999
  • Cell-cycle-dependent and ATM-independent expression of human Chk1 kinase.
    Kaneko YS, Watanabe N, Morisaki H, Akita H, Fujimoto A, Tominaga K, Terasawa M, Tachibana A, Ikeda K, Nakanishi M
    Oncogene 18 3673-3681 Jun. 1999
  • Lipopolysaccharide tolerance in murine peritoneal macrophages induces downregulation of the lipopolysaccharide signal transduction pathway through mitogen-activated protein kinase and nuclear factor-kappaB cascades, but not lipopolysaccharide-incorporatio
    Tominaga K, Saito S, Matsuura M, Nakano M
    Biochimica et biophysica acta 1450 130-144 Jun. 1999
  • Lipopolysaccharide- and paclitaxel (Taxol)-induced tolerance in murine peritoneal macrophages.
    Nakano, M., Tominaga, K., Saito, S., Kirikae, F., Lin, S., Fumero, C. L., Ojima, I., and Kirikae, T.
    J. Endotoxin Res. 5 102-106 1999
  • Potent prostaglandin A1 analogs that suppress tumor cell growth through induction of p21 and reduction of cyclin E.
    Tanikawa M, Yamada K, Tominaga K, Morisaki H, Kaneko Y, Ikeda K, Suzuki M, Kiho T, Tomokiyo K, Furuta K, Noyori R, Nakanishi M
    The Journal of biological chemistry 273 18522-18527 Jul. 1998
  • Biological characterization of endotoxins released from antibiotic-treated Pseudomonas aeruginosa and Escherichia coli.
    Kirikae T, Kirikae F, Saito S, Tominaga K, Tamura H, Uemura Y, Yokochi T, Nakano M
    Antimicrobial agents and chemotherapy 42 1015-1021 May 1998
  • Lipopolysaccharide (LPS) stimulates the production of tumor necrosis factor (TNF)-alpha and expression of inducible nitric oxide synthase (iNOS) by osteoclasts (OCL) in murine bone marrow cell culture.
    Kikkawa I, Saito S, Tominaga K, Hoshino Y, Ooi Y, Nakano M
    Microbiology and immunology 42 591-598 1998
  • Lipopolysaccharide (LPS)-induced IL-6 production by embryonic fibroblasts isolated and cloned from LPS-responsive and LPS-hyporesponsive mice.
    Tominaga K, Kirikae T, Nakano M
    Molecular immunology 34 1147-1156 Nov. 1997
  • Rhodobacter sphaeroides diphosphoryl lipid A inhibits interleukin-6 production in CD14-negative murine marrow stromal ST2 cells stimulated with lipopolysaccharide or paclitaxel (taxol).
    Kirikae, T., Kirikae, F., Tominaga, K., Qureshi, N., Yamamoto, S., and Nakano, M.
    J. Endotoxin Res. 4 115-122 1997
  • An amino acid change in the non-structural NS2 protein of an influenza A virus mutant is responsible for the generation of defective interfering (DI) particles by amplifying DI RNAs and suppressing complementary RNA synthesis.
    Odagiri T, Tominaga K, Tobita K, Ohta S
    The Journal of general virology 75 ( Pt 1) 43-53 Jan. 1994
  • Smaller isoform of human mitochondrial transcription factor 1: its wide distribution and production by alternative splicing.
    Tominaga K, Hayashi J, Kagawa Y, Ohta S
    Biochemical and biophysical research communications 194 544-551 Jul. 1993
  • Upstream region of a genomic gene for human mitochondrial transcription factor 1.
    Tominaga K, Akiyama S, Kagawa Y, Ohta S
    Biochimica et biophysica acta 1131 217-219 Jun. 1992
  • Analysis of the survival of mature human eosinophils: interleukin-5 prevents apoptosis in mature human eosinophils.
    Yamaguchi Y, Suda T, Ohta S, Tominaga K, Miura Y, Kasahara T
    Blood 78 2542-2547 Nov. 1991
  • Respiration-deficient cells are caused by a single point mutation in the mitochondrial tRNA-Leu (UUR) gene in mitochondrial myopathy, encephalopathy, lactic acidosis, and strokelike episodes (MELAS).
    Kobayashi Y, Momoi MY, Tominaga K, Shimoizumi H, Nihei K, Yanagisawa M, Kagawa Y, Ohta S
    American journal of human genetics 49 590-599 Sep. 1991
  • Regulation of gene expression for the nuclear-encoded mitochondrial proteins in mammalian cells.
    Ohta, S., Tominaga, K., Kagawa ,Y., Tomura, H., and Endo, H.
    Progress in Neuropathology 7 103-112 1991
  • Multiple deletions of mitochondrial DNA in patients with familial mitochondrial myopathy.
    Kagawa, Y., Yuzaki, M., Ohta, S., Tominaga, K., Ohtsuka, M., and Kanazawa, I.
    Progress in Neuropathology 7 129-139 1991
  • A point mutation in the mitochondrial tRNA(Leu)(UUR) gene in MELAS (mitochondrial myopathy, encephalopathy, lactic acidosis and stroke-like episodes).
    Kobayashi Y, Momoi MY, Tominaga K, Momoi T, Nihei K, Yanagisawa M, Kagawa Y, Ohta S
    Biochemical and biophysical research communications 173 816-822 Dec. 1990

Papers(other)

  • Paraneoplastic Cerebellar Degeneration with Bladder Cancer Confirmed the Existence of an Anti-Neural Antibody: A Case Report
    KAWANISHI KOTARO, MORITA MITSUYA, NAKAHARA KEIICHI, TEZUKA SHUICHI, KOKI TOMI, TOMINAGA KAORU, ENDO HITOSHI, YASHIRO TAKASHI, TANAKA KEIKO, NAKANO IMAHARU
    Brain Nerve 65(11) 1401-1405 Nov. 2013
  • 傍腫瘍性小脳変性症(PCD)の新規抗原(brain‐type creatine kinase;CKB)の同定
    手塚修一, 黒岩憲二, 滑川道人, 森田光哉, 冨永薫, 田中惠子, 瀧山嘉久, 遠藤仁司, 中野今治
    日本神経学会学術大会プログラム・抄録集 54th 430 2013
  • 疾患と遺伝子異常(2)Chk1欠損マウスを用いたマウスChk1キナーゼの機能解析
    高井裕之, 冨永薫, 本山昇, 池田恭治, 中西真, 永浜裕康, 中山啓子, 中山敬一
    日本臨床分子医学会記録 37 (70) Nov. 2000
  • Chk1キナーゼ欠損マウスを用いたマウスChk1キナーゼの機能解析
    高井裕之, 冨永薫, 本山昇, 池田恭治, 中西真, 永浜裕康, 中山啓子, 中山敬一
    日本分子生物学会年会プログラム・講演要旨集 22nd 261 Nov. 1999
  • ヒトChk1キナーゼの構造及び機能解析
    藤本淳司, 冨永薫, 池田恭治, 中西真
    日本分子生物学会年会プログラム・講演要旨集 21st 492 Nov. 1998
  • Infant mitochondrial disease. Features of mitochondrial gene.
    TOMINAGA KAORU
    小児内科 30(9) 1113-1117 Sep. 1998
  • Cell Cycle Control on Cellular Senescence.
    TOMINAGA KAORU, NAKANISHI MAKOTO
    細胞工学 17(9) 1363-1367 Sep. 1998
  • Induction of p21CKI Expression and Cell Cycle Arrest by Prostaglandin A1 Analogues.
    TOMINAGA KAORU, TANIKAWA MOTONORI, KANEKO YOKO, KIHO TOSHIHIRO, TOMOKIYO KEIICHIRO, FURUTA KYOSHI, NOYORI RYOJI, SUZUKI MASAAKI, IKEDA KYOJI
    日本分子生物学会年会プログラム・講演要旨集 20th 417 Dec. 1997
  • Cell surface CD14 dependence activation and independence activation of macrophage by means of LPS.
    SAITO SHINJI, TOMINAGA KAORU, KIRIKAE TERUO, MATSUURA MOTOHIRO, NAKANO MASAYASU
    日本免疫学会総会・学術集会記録 27 163 Oct. 1997
  • Relationship between NO production and IL-12 production from mouse abdominal cavity macrophage by LPS stimulation.
    MATSUURA MOTOHIRO, TOMINAGA KAORU, SAITO SHINJI, MATSUMURA HARUO, NAKANO MASAYASU
    日本免疫学会総会・学術集会記録 27 296 Oct. 1997
Display all
Papers(other)close
  • Paraneoplastic Cerebellar Degeneration with Bladder Cancer Confirmed the Existence of an Anti-Neural Antibody: A Case Report
    KAWANISHI KOTARO, MORITA MITSUYA, NAKAHARA KEIICHI, TEZUKA SHUICHI, KOKI TOMI, TOMINAGA KAORU, ENDO HITOSHI, YASHIRO TAKASHI, TANAKA KEIKO, NAKANO IMAHARU
    Brain Nerve 65(11) 1401-1405 Nov. 2013
  • 傍腫瘍性小脳変性症(PCD)の新規抗原(brain‐type creatine kinase;CKB)の同定
    手塚修一, 黒岩憲二, 滑川道人, 森田光哉, 冨永薫, 田中惠子, 瀧山嘉久, 遠藤仁司, 中野今治
    日本神経学会学術大会プログラム・抄録集 54th 430 2013
  • 疾患と遺伝子異常(2)Chk1欠損マウスを用いたマウスChk1キナーゼの機能解析
    高井裕之, 冨永薫, 本山昇, 池田恭治, 中西真, 永浜裕康, 中山啓子, 中山敬一
    日本臨床分子医学会記録 37 (70) Nov. 2000
  • Chk1キナーゼ欠損マウスを用いたマウスChk1キナーゼの機能解析
    高井裕之, 冨永薫, 本山昇, 池田恭治, 中西真, 永浜裕康, 中山啓子, 中山敬一
    日本分子生物学会年会プログラム・講演要旨集 22nd 261 Nov. 1999
  • ヒトChk1キナーゼの構造及び機能解析
    藤本淳司, 冨永薫, 池田恭治, 中西真
    日本分子生物学会年会プログラム・講演要旨集 21st 492 Nov. 1998
  • Infant mitochondrial disease. Features of mitochondrial gene.
    TOMINAGA KAORU
    小児内科 30(9) 1113-1117 Sep. 1998
  • Cell Cycle Control on Cellular Senescence.
    TOMINAGA KAORU, NAKANISHI MAKOTO
    細胞工学 17(9) 1363-1367 Sep. 1998
  • Induction of p21CKI Expression and Cell Cycle Arrest by Prostaglandin A1 Analogues.
    TOMINAGA KAORU, TANIKAWA MOTONORI, KANEKO YOKO, KIHO TOSHIHIRO, TOMOKIYO KEIICHIRO, FURUTA KYOSHI, NOYORI RYOJI, SUZUKI MASAAKI, IKEDA KYOJI
    日本分子生物学会年会プログラム・講演要旨集 20th 417 Dec. 1997
  • Cell surface CD14 dependence activation and independence activation of macrophage by means of LPS.
    SAITO SHINJI, TOMINAGA KAORU, KIRIKAE TERUO, MATSUURA MOTOHIRO, NAKANO MASAYASU
    日本免疫学会総会・学術集会記録 27 163 Oct. 1997
  • Relationship between NO production and IL-12 production from mouse abdominal cavity macrophage by LPS stimulation.
    MATSUURA MOTOHIRO, TOMINAGA KAORU, SAITO SHINJI, MATSUMURA HARUO, NAKANO MASAYASU
    日本免疫学会総会・学術集会記録 27 296 Oct. 1997
  • Regulation of cell cycle control, carcinogenesis and senescence by nuclear serine/threonine kinases.
    TOMINAGA KAORU, KANEKO YOKO, NAKANISHI MAKOTO
    実験医学 15(14) 1725-1729 Sep. 1997
  • Endotoxin-induced cytokines.
    NAKANO MASAYASU, KIRIKAE TERUO, TOMINAGA KAORU
    化学療法の領域 13(4) 665-674 Apr. 1997
  • Effect of LPS tolerance in LPS signal transmission of mouse macrophage.
    TOMINAGA KAORU, SAITO SHINJI, MATSUURA MOTOHIRO, NAKANO MASAYASU
    日本免疫学会総会・学術集会記録 26 391 Oct. 1996
  • Role of CD14 in induction of LPS tolerance in macrophage system cells.
    MATSUURA MOTOHIRO, TOMINAGA KAORU, NAKANO MASAYASU
    日本免疫学会総会・学術集会記録 26 390 Oct. 1996
  • The difference of LPS signal transmmission routes in CD14-positive and negative mouse macrophage cell lines.
    SAITO SHINJI, TOMINAGA KAORU, KIRIKAE TERUO, MATSUURA MOTOHIRO, NAKANO MASAYASU
    日本免疫学会総会・学術集会記録 26 390 Oct. 1996
  • Pole of MAP kinase in macrophage activation by lipopolysaccharide (LPS).
    TOMINAGA KAORU, SAITO SHINJI, MATSUURA MOTOHIRO, NAKANO MASAYASU
    日本分子生物学会年会プログラム・講演要旨集 19th 348 Jul. 1996
  • SV40ウイルスDNA導入により株化されたマウス胎児線維芽細胞のリポ多糖(LPS)応答性とLPSシグナル伝達系の解析
    冨永薫, 中野昌康
    日本免疫学会総会・学術集会記録 25 174 Oct. 1995
  • CD14陽性マウスマクロファージ細胞株のLPS誘導NO産生の調節機構
    斎藤慎二, 切替照雄, 切替富美子, 冨永薫, 中野昌康
    日本免疫学会総会・学術集会記録 25 290 Oct. 1995
  • Relation between LPS signaling and CD14 molecule.
    SAITO SHINJI, KIRIKAE TERUO, KIRIKAE FUMIKO, TOMINAGA KAORU, YAMAMOTO SHUNSUKE, NAKANO MASAYASU
    日本免疫学会総会・学術集会記録 24 594 Oct. 1994
  • Embryonic fibroblasts taken from LPS-hyporesponsive C3H/HeJ mice are still hyporesponsive to LPS.
    TOMINAGA KAORU, KIRIKAE TERUO, YAMAMOTO SHUNSUKE, NAKANO MASAYASU
    日本免疫学会総会・学術集会記録 24 336 Oct. 1994
  • Mitochondrial disease.The new prospects.Regulation of expression of the mitochondrial DNA by nuclear genes.
    TOMINAGA KAORU, KAGAWA YASUO
    臨床科学 30(4) 453-463 Apr. 1994


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