takahashi hidenori

FacultyOphthalmology
Job titleAssociate ProfessorWeb sitehttp://kaken.nii.ac.jp/d/r/10361479.en.html

Profile

Profile

Medical and Surgical Retina

Research Keywords

    Age-related Macular Degeneration, Diabetes Mellitus Retinopathy, Retinal Vein Occlusion, Molecular Biology, Vascular Endothelial Growth Factor

Research Areas

  • Clinical surgery / Ophthalmology

Career

  • Apr.2012
    -
    Today
    Jichi Medical University Ophthalmology, Assistant Professor
  • Apr.2008
    -
    Jun.2008
    The University of Tokyo Ophthalmology, Medical Staff
  • Jul.2009
    -
    Mar.2012
    JCHO Tokyo Shinjuku Medical Center Ophthalmology, Medical Chief
  • Apr.2009
    -
    Jun.2009
    JCHO Tokyo Shinjuku Medical Center Ophthalmology, Medical Staff
  • Jul.2008
    -
    Mar.2009
    The University of Tokyo Ophthalmology, Research Associate
  • Apr.2004
    -
    Mar.2008
    The University of Tokyo Ophthalmology, Graduate Student
  • Apr.2003
    -
    Mar.2004
    The University of Tokyo Ophthalmology, Technical Official
  • May2001
    -
    Mar.2003
    The University of Tokyo Ophthalmology, Intern Doctor
  • Apr.1997
    -
    Mar.2001
    The University of Tokyo Medical Department, Student
  • Apr.1995
    -
    Mar.1997
    The University of Tokyo General Education, Student
  • Apr.1989
    -
    Mar.1995
    Eikogakuen
  • Apr.1983
    -
    Mar.1989
    Yokohama City Fudomaru Elementary School

Research Activities

Papers(paper)

  • The Angiotensin II Receptor Antagonist, Losartan, Enhances Regulator of G Protein Signaling 2 mRNA Expression in Vascular Smooth Muscle Cells of Wistar Rat
    Wu Y, Nakagawa S, Takahashi H, Kawabata Y, Suzuki E, Uehara Y.
    Hypertension Research 1-7 Jan. 2016
  • Angiographic findings of ranibizumab-resistant polypoidal choroidal vasculopathy after switching to a treat and extend regimen with intravitreal aflibercept
    Keiko Azuma, Yoko Nomura, Hidenori Takahashi, Ryo Obata, Yasuo Yanagi
    Retina 2016
  • Vascular endothelial growth factor (VEGF) concentration is underestimated by enzyme-linked immunosorbent assay in the presence of anti-VEGF drugs
    Hidenori Takahashi, Yoko Nomura, Junko Nishida, Yujiro Fujino, Yasuo Yanagi, Hidetoshi Kawashima
    Invest Ophthalmol Vis Sci 2016
  • Impaired response of regulator of Gαq signaling-2 mRNA to angiotensin II and hypertensive renal injury in Dahlsalt-sensitive rats.
    Wu Y, Takahashi H, Suzuki E, Kruzliak P, Soucek M, Uehara Y.
    Hypertens Res. Nov. 2015
  • Two Cases of Rapid Thinning of the Choroid Prior to Appearance of Polypoid Lesions
    Sakamoto S, Arai Y, Takahashi H, Fujino Y, Obata R, Yanagi Y, Kawashima H
    JSM Ophthalmology 3 1033 Oct. 2015
  • Association between aqueous humor C-X-C motif chemokine ligand 13 levels and subfoveal choroidal thickness in normal older subjects.
    Nomura Y, Takahashi H, Fujino Y, Kawashima H, Yanagi Y.
    Retina. 2015
  • Effect of posterior vitreous detachment on aqueous humor level of vascular endothelial growth factor in exudative age-related macular degeneration patients.
    Nomura Y, Takahashi H, Tan X, Fujino Y, Kawashima H, Yanagi Y.
    Graefes Arch Clin Exp Ophthalmol. Apr. 2015
  • RELATIONSHIP BETWEEN VISUAL PROGNOSIS AND DELAY OF INTRAVITREAL INJECTION OF RANIBIZUMAB WHEN TREATING AGE-RELATED MACULAR DEGENERATION.
    Takahashi H, Ohkubo Y, Sato A, Takezawa M, Fujino Y, Yanagi Y, Kawashima H.
    Retina. Feb. 2015
  • Effects of posterior vitreous detachment on aqueous humour levels of VEGF and inflammatory cytokines.
    Takahashi H, Nomura Y, Tan X, Fujino Y, Kawashima H, Yanagi Y.
    Br J Ophthalmol. Feb. 2015
  • Widespread choroidal thickening and abnormal midperipheral fundus autofluorescence characterize exudative age-related macular degeneration with choroidal vascular hyperpermeability.
    Nomura Y, Takahashi H, Tan X, Obata R, Yanagi Y.
    Clin Ophthalmol. 11(9) 297-304 Feb. 2015
Display all
Papers(paper)close
  • The Angiotensin II Receptor Antagonist, Losartan, Enhances Regulator of G Protein Signaling 2 mRNA Expression in Vascular Smooth Muscle Cells of Wistar Rat
    Wu Y, Nakagawa S, Takahashi H, Kawabata Y, Suzuki E, Uehara Y.
    Hypertension Research 1-7 Jan. 2016
  • Angiographic findings of ranibizumab-resistant polypoidal choroidal vasculopathy after switching to a treat and extend regimen with intravitreal aflibercept
    Keiko Azuma, Yoko Nomura, Hidenori Takahashi, Ryo Obata, Yasuo Yanagi
    Retina 2016
  • Vascular endothelial growth factor (VEGF) concentration is underestimated by enzyme-linked immunosorbent assay in the presence of anti-VEGF drugs
    Hidenori Takahashi, Yoko Nomura, Junko Nishida, Yujiro Fujino, Yasuo Yanagi, Hidetoshi Kawashima
    Invest Ophthalmol Vis Sci 2016
  • Impaired response of regulator of Gαq signaling-2 mRNA to angiotensin II and hypertensive renal injury in Dahlsalt-sensitive rats.
    Wu Y, Takahashi H, Suzuki E, Kruzliak P, Soucek M, Uehara Y.
    Hypertens Res. Nov. 2015
  • Two Cases of Rapid Thinning of the Choroid Prior to Appearance of Polypoid Lesions
    Sakamoto S, Arai Y, Takahashi H, Fujino Y, Obata R, Yanagi Y, Kawashima H
    JSM Ophthalmology 3 1033 Oct. 2015
  • Association between aqueous humor C-X-C motif chemokine ligand 13 levels and subfoveal choroidal thickness in normal older subjects.
    Nomura Y, Takahashi H, Fujino Y, Kawashima H, Yanagi Y.
    Retina. 2015
  • Effect of posterior vitreous detachment on aqueous humor level of vascular endothelial growth factor in exudative age-related macular degeneration patients.
    Nomura Y, Takahashi H, Tan X, Fujino Y, Kawashima H, Yanagi Y.
    Graefes Arch Clin Exp Ophthalmol. Apr. 2015
  • RELATIONSHIP BETWEEN VISUAL PROGNOSIS AND DELAY OF INTRAVITREAL INJECTION OF RANIBIZUMAB WHEN TREATING AGE-RELATED MACULAR DEGENERATION.
    Takahashi H, Ohkubo Y, Sato A, Takezawa M, Fujino Y, Yanagi Y, Kawashima H.
    Retina. Feb. 2015
  • Effects of posterior vitreous detachment on aqueous humour levels of VEGF and inflammatory cytokines.
    Takahashi H, Nomura Y, Tan X, Fujino Y, Kawashima H, Yanagi Y.
    Br J Ophthalmol. Feb. 2015
  • Widespread choroidal thickening and abnormal midperipheral fundus autofluorescence characterize exudative age-related macular degeneration with choroidal vascular hyperpermeability.
    Nomura Y, Takahashi H, Tan X, Obata R, Yanagi Y.
    Clin Ophthalmol. 11(9) 297-304 Feb. 2015
  • Excessive retinol intake exacerbates choroidal neovascularization through upregulated vascular endothelial growth factor in retinal pigment epithelium in mice.
    Tan X, Takahashi H, Nishida J, Aoki A, Inoue T, Yanagi Y.
    Exp Eye Res. 131 77-83 Feb. 2015
  • Effects of vitreomacular adhesion on ranibizumab treatment in Japanese patients with age-related macular degeneration.
    Nomura Y, Takahashi H, Tan X, Fujimura S, Obata R, Yanagi Y.
    Jpn J Ophthalmol. 58(5) 443-447 Sep. 2014
  • Occult macular dystrophy with bilateral chronic subfoveal serous retinal detachment associated with a novel RP1L1 mutation (p.S1199P).
    Takahashi H, Hayashi T, Tsuneoka H, Nakano T, Yamada H, Katagiri S, Fujino Y, Noda Y, Yoshimoto M, Kawashima H.
    Doc Ophthalmol. 129(1) 49-56 Aug. 2014
  • Characteristics of fundus autofluorescence and drusen in the fellow eyes of Japanese patients with exudative age-related macular degeneration
    Fujimura S, Ueta T, Takahashi H, Obata R, Smith RT, Yanagi Y
    Graefes Arch Clin Exp Ophthalmol 251(12) 1-9 Dec. 2013
  • Changes in parafoveal retinal thickness and subfoveal choroidal thickness in a patient with dengue fever-associated maculopathy
    Yamamoto K, Takahashi H, Kanno M, Noda Y, Fujino Y
    J Ophthalmic Inflamm Infect 3(1) 63-66 Oct. 2013
  • Tomographic and angiographic characteristics of eyes with macular focal choroidal excavation.
    Obata R, Takahashi H, Ueta T, Yuda K, Kure K, Yanagi Y.
    Retina 33(6) 1201-1210 Jun. 2013
  • Adrenomedullin Inhibits Choroidal Neovascularization via CCL2 in the Retinal Pigment Epithelium
    Yuda K, Takahashi H, Inoue T, Ueta T, Iriyama A, Kadonosono K, Tamaki Y, Aburatani H, Nagai R, Yanagi Y
    Am J Pathol 181(4) 1464-1472 Oct. 2012
  • Angiostatic effect of CXCR3 expressed on choroidal neovascularization
    Fujimura S, Takahashi H, Yuda K, Ueta T, Iriyama A, Inoue T, Kaburaki T, Tamaki Y, Matsushima K, Yanagi Y
    Invest Ophthalmol Vis Sci 53(4) 1999-2006 Apr. 2012
  • Background comparison of typical age-related macular degeneration and polypoidal choroidal vasculopathy in Japanese patients
    Ueta T, Obata R, Inoue Y, Iriyama A, Takahashi H, Yamaguchi T, Tamaki Y, Yanagi Y
    Ophthalmology 116(12) 2400-2406 Dec. 2009
  • A2E, a component of lipofuscin, is pro-angiogenic in vivo
    Iriyama A, Inoue Y, Takahashi H, Tamaki Y, Jang WD, Yanagi Y
    J Cell Physiol 220(2) 469-475 Aug. 2009
  • Identification of a novel vascular endothelial growth factor receptor 2 inhibitor and its effect for choroidal neovascularization in vivo
    Takahashi H, Tamaki Y, Ishii N, Oikawa N, Mizuguchi E, Francis JH, Inoue Y, Iriyama A, Obata R, Yanagi Y
    Curr Eye Res 33(11) 1002-1010 Nov. 2008
  • A2E, a pigment of the lipofuscin of retinal pigment epithelial cells, is an endogenous ligand for retinoic acid receptor
    Iriyama A, Fujiki R, Inoue Y, Takahashi H, Tamaki Y, Takezawa S, Takeyama K, Jang WD, Kato S, Yanagi Y
    J Biol Chem 283(18) 11947-11953 May 2008
  • Suppression of choroidal neovascularization by vaccination with epitope peptide derived from human VEGF receptor 2 in an animal model
    Takahashi H, Ishizaki H, Tahara H, Tamaki Y, Yanagi Y
    Invest Ophthalmol Vis Sci 49(5) 2143-2147 May 2008
  • Effect of posterior juxtascleral triamcinolone acetonide on the efficacy and choriocapillaris hypoperfusion of photodynamic therapy
    Iriyama A, Obata R, Inoue Y, Takahashi H, Tamaki Y, Yanagi Y
    Graefes Arch Clin Exp Ophthalmol 246(3) 339-344 Mar. 2008
  • Development of typical age-related macular degeneration and polypoidal choroidal vasculopathy in fellow eyes of Japanese patients with exudative age-related macular degeneration
    Ueta T, Iriyama A, Francis J, Takahashi H, Adachi T, Obata R, Inoue Y, Tamaki Y, Yanagi Y
    Am J Ophthalmol 146(1) 96-101 2008
  • Expression of hypoxia-inducible factor 1alpha and 2alpha in choroidal neovascular membranes associated with age-related macular degeneration
    Inoue Y, Yanagi Y, Matsuura K, Takahashi H, Tamaki Y, Araie M
    Br J Ophthalmol 91(12) 1720-1721 Dec. 2007
  • Subretinal transplantation of bone marrow mesenchymal stem cells delays retinal degeneration in the RCS rat model of retinal degeneration
    Inoue Y, Iriyama A, Ueno S, Takahashi H, Kondo M, Tamaki Y, Araie M, Yanagi Y
    Exp Eye Res 85(2) 234-241 Aug. 2007
  • Triamcinolone acetonide suppresses early proangiogenic response in retinal pigment epithelial cells after photodynamic therapy in vitro
    Obata R, Iriyama A, Inoue Y, Takahashi H, Tamaki Y, Yanagi Y
    Br J Ophthalmol 91(1) 100-104 Jan. 2007
  • A novel vascular endothelial growth factor receptor 2 inhibitor, SU11248, suppresses choroidal neovascularization in vivo
    Takahashi H, Obata R, Tamaki Y
    J Ocul Pharmacol Ther 22(4) 213-218 Aug. 2006
  • Polypoidal choroidal vasculopathy and retinochoroidal anastomosis in Japanese patients eligible for photodynamic therapy for exudative age-related macular degeneration
    Obata R, Yanagi Y, Kami J, Takahashi H, Inoue Y, Tamaki Y
    Jpn J Ophthalmol 50(4) 354-360 Jul. 2006
  • ight-induced gene transfer from packaged DNA enveloped in a dendrimeric photosensitizer
    Nishiyama N, Iriyama A, Jang WD, Miyata K, Itaka K, Inoue Y, Takahashi H, Yanagi Y, Tamaki Y, Koyama H, Kataoka K
    Nat Mater 4(12) 934-941 Dec. 2005
  • Suppression of laser-induced choroidal neovascularization by oral administration of SA3443 in mice
    Muranaka K, Yanagi Y, Tamaki Y, Takahashi H, Usui T, Ohashi K, Matsuoka H, Senda T
    FEBS Lett 579(27) 6084-6088 Nov. 2005
  • Sequential change of ophthalmic findings after bypass graft surgery in Takayasu disease
    Kinoshita N, Yanagi Y, Tamaki Y, Obata R, Takahashi H
    Retina 25(2) 225-227 2005
  • COX-2-selective inhibitor, etodolac, suppresses choroidal neovascularization in a mice model
    Takahashi H, Yanagi Y, Tamaki Y, Uchida S, Muranaka K
    Biochem Biophys Res Commun 325(2) 461-466 Dec. 2004
  • Case Report of Orbital Cellulitis following Conjunctivitis
    TAKAHASHI Hidenori, SHIBUI Hirobumi, MATSUO Hiroshi, ARAIE Makoto
    Journal of the eye 21(9) 1245-1248 Sep. 2004
  • Contribution of bone-marrow-derived cells to choroidal neovascularization
    Takahashi H, Yanagi Y, Tamaki Y, Muranaka K, Usui T, Sata M
    Biochem Biophys Res Commun 320(2) 372-375 Jul. 2004
  • Clinical and functional findings in crystalline retinopathy
    Yanagi Y, Tamaki Y, Takahashi H, Sekine H, Mori M, Hirato T, Okajima O
    Retina 24(2) 267-274 2004
  • A Case of Bilateral Retinal Detachment Presumably Caused by Self Inflicted Trauma
    TAKAHASHI Hidenori, SAKURAI Masahiko, SHIBUI Hirobumi, IMAMURA Asuka, FUKUSHIMA Harumi, KABURAKI Katsutoshi
    16(2) 259-262 Apr. 2003
  • Effective Intravitreal Injections of Bevacizumab in a Case of Serous Macular Detachment from the Superior Border of Posterior Staphyloma
    Yukiko Tsubota, Hidenori Takahashi, Kenji Sugisaki, Tatsuro Tanabe, Yujiro Fujino
    Case Rep Ophthalmol 2017
  • Novel Preretinal Hair Pin-Like Vessel in Retinal Astrocytic Hamartoma with Vitreous Hemorrhage
    Megumi Soeta, Yusuke Arai, Hidenori Takahashi, Yujiro Fujino, Tatsuro Tanabe, Yuji Inoue, Hidetoshi Kawashima
    Retinal Cases and Brief Reports Oct. 2016
  • A high-salt diet enhances leukocyte adhesion in association with kidney injury in young dahl salt-sensitive rats
    Hidenori Takahashi, Suguru Nakagawa, Yaqiong Wu, Yukari Kawabata, Atsushi Numabe, Yasuo Yanagi, Yasuhiro Tamaki, Yoshio Uehara and Makoto Araie
    Hypertension Research Mar. 2017
  • Applying artificial intelligence to disease staging: Deep learning for improved staging of diabetic retinopathy
    Hidenori Takahashi
    PLOS ONE Jun. 2017
  • Changes in multiple cytokine concentrations in the aqueous humour of neovascular age-related macular degeneration after 2 months of ranibizumab therapy
    Shinichi Sakamoto, Hidenori Takahashi, Xue Tan, Yuji Inoue, Yoko Nomura, Yusuke Arai, Yujiro Fujino, Hidetoshi Kawashima, Yasuo Yanagi
    British Journal of Ophthalmology Aug. 2017
  • A prospective multicenter study on genome wide associations to ranibizumab treatment outcome for age-related macular degeneration
    Yamashiro K, Mori K, Honda S, Kano M, Yanagi Y, Obana A, Sakurada Y, Sato T, Nagai Y, Hikichi T, Kataoka Y, Hara C, Koyama Y, Koizumi H, Yoshikawa M, Miyake M, Nakata I, Tsuchihashi T, Horie-Inoue K, Matsumiya W, Ogasawara M, Obata R, Yoneyama S, Matsumoto H, Ohnaka M, Kitamei H, Sayanagi K, Ooto S, Tamura H, Oishi A, Kabasawa S, Ueyama K, Miki A, Kondo N, Bessho H, Saito M, Takahashi H, Tan X, Azuma K, Kikushima W, Mukai R, Ohira A, Gomi F, Miyata K, Takahashi K, Kishi S, Iijima H, Sekiryu T, Iida T, Awata T, Inoue S, Yamada R, Matsuda F, Tsujikawa A, Negi A, Yoneya S, Iwata T, Yoshimura N
    Sci Rep 7(1) 9196 Aug. 2017
  • Changes of outer retinal microstructures after photodynamic therapy for chronic central serous chorioretinopathy
    Shimizu K, Hashimoto Y, Azuma K, Nomura Y, Obata R, Takahashi H, Yanagi Y
    Clin Ophthalmol 11 1505-1512 Aug. 2017


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