matsura toru

FacultyInternalMedicineNeurology
Job titleProfessorWeb site

Profile

Research Areas

  • Biological science / Molecular biology
  • Basic medicine / Human genetics
  • Clinical internal medicine / Neurology

Career

  • 1998
    - Postdoctoral Fellow, Neurology, Baylor College of Medicine
  • 2000
    - Instructor, Neurology, Baylor College of Medicine
  • 2002
    - Assistant Professor, Molecular and Human Genetics, Baylor College of Medicine

Academic Societies

  • American Society of Human Genetics (ASHG)
  • The Society for Neuroscience (SFN)
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Academic Societiesclose
  • American Society of Human Genetics (ASHG)
  • The Society for Neuroscience (SFN)

Research Activities

Papers(other)

  • Ancestral Origin of the ATTCT Repeat Expansion in Spinocerebellar Ataxia Type 10 (SCA10).
    Sequeiros J., Matsuura T., Silveira I., Almeida T., Martins S., Alonso I., Azevedo L., Ramos E.M., Amorim A., Ohno K., Jardim L.B., Saraiva-Pereira M.L.
    PLoS One 4(2) 2009
  • Myotonic dystrophy type 2 in Japan: ancestral origin distinct from Caucasian families.
    Matsuura T., Saito T., Kimura T., Amakusa Y., Aizawa H., Yahara O., Day J.W., Ikeda Y., Ohno K., Ranum L.P.W.
    Neurogenetics 9(1) 61-63 2008
  • Instability of expanded CAG/CAA repeats in spinocerebellar ataxia type 17.
    Gao R., Coolbaugh M., Matsuura T., Nakamura K., Zühlke C., Siciliano M.J., Rasmussen A., Lin X., Ashizawa T.
    Eur J Hum Genet 16(2) 215-222 2008
  • Long-range PCR for the diagnosis of spinocerebellar ataxia type 10.
    UEDA S, OHNO K, MATSUURA T, KUROSAKI T
    Neurogenetics 9(2) 151-152 2008
  • Human branch point consensus sequence is yUnAy.
    GAO Kaiping, MASUDA Akio, MATSUURA Tohru, OHNO Kinji
    Nucleic Acids Research 36(7) 2257-2267 2008
  • HnRNP H enhances skipping of a nonfunctional exon P3A in CHRNA1 and a mutation disrupting its binding causes congenital myasthenic syndrome.
    OHNO K, ENGEL Ag, MATSUURA T, ITO M, SHEN Xm, MASUDA A
    Hum Mol Genet 17(24) 4022-4035 2008
  • The ATTCT repeats of spinocerebellar ataxia type 10 display strong nucleosome assembly which is enhanced by repeat interruptions.
    HAGERMAN Katharine A., HAGERMAN Katharine A., RUAN Haihe, EDAMURA Kerrie Nichol, MATSUURA Tohru, PEARSON Christopher E., PEARSON Christopher E., WANG Yuh-hwa
    Gene 434(1-2) 29-34 2008
  • Thermodynamic instability of siRNA duplex is a prerequisite for dependable prediction of siRNA activities.
    SHINMI J, YATSUYA H, QIAO S, TAKAHASHI M, OHNO K, ISHIDA M, JIJIWA M, ASAI N, MATSUURA T, MASUDA A, MURAKUMO Y, ICHIHARA M
    Nucleic Acids Research 35(18) 2007
  • In vitro and in silico analysis reveals an efficient algorithm to predict the splicing consequences of mutations at the 5' splice sites.
    SAHASHI Kentaro, MASUDA Akio, MATSUURA Tohru, SHINMI Jun, ZHANG Zhujun, TAKESHIMA Yasuhiro, MATSUO Masafumi, SOBUE Gen, OHNO Kinji
    Nucleic Acids Research 35(18) 5995-6003 2007
  • Interruptions in the expanded ATTCT repeat of spinocerebellar ataxia type 10. Repeat purity as a disease modifier?
    MATSUURA Tohru, FANG Ping, PEARSON Christopher E., PEARSON Christopher E., JAYAKAR Parul, ASHIZAWA Tetsuo, ROA Benjamin B., NELSON David L.
    Am J Hum Genet 78(1) 125-129 2006
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Papers(other)close
  • Ancestral Origin of the ATTCT Repeat Expansion in Spinocerebellar Ataxia Type 10 (SCA10).
    Sequeiros J., Matsuura T., Silveira I., Almeida T., Martins S., Alonso I., Azevedo L., Ramos E.M., Amorim A., Ohno K., Jardim L.B., Saraiva-Pereira M.L.
    PLoS One 4(2) 2009
  • Myotonic dystrophy type 2 in Japan: ancestral origin distinct from Caucasian families.
    Matsuura T., Saito T., Kimura T., Amakusa Y., Aizawa H., Yahara O., Day J.W., Ikeda Y., Ohno K., Ranum L.P.W.
    Neurogenetics 9(1) 61-63 2008
  • Instability of expanded CAG/CAA repeats in spinocerebellar ataxia type 17.
    Gao R., Coolbaugh M., Matsuura T., Nakamura K., Zühlke C., Siciliano M.J., Rasmussen A., Lin X., Ashizawa T.
    Eur J Hum Genet 16(2) 215-222 2008
  • Long-range PCR for the diagnosis of spinocerebellar ataxia type 10.
    UEDA S, OHNO K, MATSUURA T, KUROSAKI T
    Neurogenetics 9(2) 151-152 2008
  • Human branch point consensus sequence is yUnAy.
    GAO Kaiping, MASUDA Akio, MATSUURA Tohru, OHNO Kinji
    Nucleic Acids Research 36(7) 2257-2267 2008
  • HnRNP H enhances skipping of a nonfunctional exon P3A in CHRNA1 and a mutation disrupting its binding causes congenital myasthenic syndrome.
    OHNO K, ENGEL Ag, MATSUURA T, ITO M, SHEN Xm, MASUDA A
    Hum Mol Genet 17(24) 4022-4035 2008
  • The ATTCT repeats of spinocerebellar ataxia type 10 display strong nucleosome assembly which is enhanced by repeat interruptions.
    HAGERMAN Katharine A., HAGERMAN Katharine A., RUAN Haihe, EDAMURA Kerrie Nichol, MATSUURA Tohru, PEARSON Christopher E., PEARSON Christopher E., WANG Yuh-hwa
    Gene 434(1-2) 29-34 2008
  • Thermodynamic instability of siRNA duplex is a prerequisite for dependable prediction of siRNA activities.
    SHINMI J, YATSUYA H, QIAO S, TAKAHASHI M, OHNO K, ISHIDA M, JIJIWA M, ASAI N, MATSUURA T, MASUDA A, MURAKUMO Y, ICHIHARA M
    Nucleic Acids Research 35(18) 2007
  • In vitro and in silico analysis reveals an efficient algorithm to predict the splicing consequences of mutations at the 5' splice sites.
    SAHASHI Kentaro, MASUDA Akio, MATSUURA Tohru, SHINMI Jun, ZHANG Zhujun, TAKESHIMA Yasuhiro, MATSUO Masafumi, SOBUE Gen, OHNO Kinji
    Nucleic Acids Research 35(18) 5995-6003 2007
  • Interruptions in the expanded ATTCT repeat of spinocerebellar ataxia type 10. Repeat purity as a disease modifier?
    MATSUURA Tohru, FANG Ping, PEARSON Christopher E., PEARSON Christopher E., JAYAKAR Parul, ASHIZAWA Tetsuo, ROA Benjamin B., NELSON David L.
    Am J Hum Genet 78(1) 125-129 2006
  • Reduced penetrance of intermediate size alleles in spinocerebellar ataxia type 10.
    ALONSO I, JARDIM Lb, ARTIGALAS O, SARAIVA-PEREIRA Ml, MATSUURA T, ASHIZAWA T, SEQUEIROS J, SILVEIRA I
    Neurology 66(10) 1602-1604 2006
  • The role of ataxin 10 in spinocerebellar ataxia type 10 pathogenesis.
    Wakamiya M., Liu Y., Matsuura T., Gao R., Schuster G.C., Sarkar P.S., Xu W., Ashizawa T., Lin X.
    Neurology 67(4) 607-613 2006
  • FXTAS, SCA10, and SCA17 in American patients with movement disorders.
    Margolis R.L., Seixas A.I., Lin M., Maurer M.H., Ahuja A., Callahan C., Ross C.A., Matsuura T., Silveira I., Hisama F.M.
    Am J Med Genet A. 136 A(1) 87-89 2005
  • A rare truncating mutation in ADH1C (G78stop) shows significant association with Parkinson’s disease in a large international sample.
    Olson L., Singleton A., McMahon F.J., Anvret M., Sydow O., Buervenich S., Galter D., Carmine A., Johnels B., Shahabi H.N., Ahlberg J., Holmberg B., Eerola J., Nissbrandt H., Tienari P.J., Hellström O., Ashizawa T., Matsuura T., Klockgether T., Wüllner U., Gasser T., Zimprich A., Waseem S., Hanson M.
    Arch Neurol 62(1) 74-78 2005
  • Somatic and germline instability of the ATTCT repeat in spinocerebellar ataxia type 10.
    Zoghbi H.Y., Pulst S.M., Roa B.B., Nelson D.L., Ashizawa T., Matsuura T., Lin X., Fang P., Tsuji K., Khajavi M., Grewal R.P., Rasmussen A., Alonso M.F., Achari M.
    Am J Hum Genet 74(6) 1216-1224 2004
  • Dominantly inherited ataxia and dysphonia with dentate calcification: spinocerebellar ataxia type 20.
    Knight M.A., Bahlo M., Gardner R.J.McK., Dixon J.A., Matsuura T., Storey E., Forrest S.M.
    Brain 127(5) 1172-1181 2004
  • Detection of large pathogenic expansions in FRDA1, SCA10, and SCA12 genes using a simple fluorescent repeat-primed PCR assay.
    J Mol Diag 6 96-100 2004
  • Neurophysiological findings in SPG4 are variable, dependent on the type of spastin mutation.
    Neurology e-letters 2003
  • Huntington’s disease-like 2 can present as chorea-acanthocytosis.
    Neurology 61 1002-1004 2003
  • Spinocerebellar ataxia type 15 (SCA15) maps to 3p24.2-3pter: exclusion of the ITPR1 gene, the human orthologue of an ataxic mouse mutant.
    Knight M.A., Anney R.J., Kennerson M.L., Nicholson G.A., Matsuura T., Gardner R.J.M., Salimi-Tari P., Forrest S.M., Storey E.
    Neurobiol Dis 13(2) 147-157 2003
  • Unpaired Structures in SCA10 (ATTCT)(n).(AGAAT)(n) Repeats.
    POTAMAN V N, BISSLER J J, HASHEM V I, OUSSATCHEVA E A, LU L, SHLYAKHTENKO L S, LYUBCHENKO Y L, MATSUURA T, ASHIZAWA T
    J Mol Biol 326(4) 1095-1111 2003
  • Polymerase chain reaction amplification of expanded ATTCT repeat in spinocerebellar ataxia type 10.
    Matsuura T., Ashizawa T.
    Ann Neurol 51(2) 271-272 2002
  • Spinocerebellar ataxia type 10 is rare in populations other than Mexicans.
    Neurology 58 983-984 2002
  • Spinocerebellar ataxia type 10 in the French population.
    Alonso E., Rasmussen A., Fujigasaki H., Camuzat A., Tardieu S., Leguern E., Stevanin G., Ashizawa T., Matsuura T., Brice A., Dürr A.
    Ann Neurol 51(3) 408-409 2002
  • Clinical features and ATTCT repeat expansion in spinocerebellar ataxia type 10.
    Grewal R.P., Matsuura T., Achari M., Tayag E., Durazo A., Pulst S.M., Zu L., Ashizawa T.
    Arch Neurol 59(8) 1285-1290 2002
  • Spastin gene mutation in Japanese with hereditary spastic paraplegia.
    J Med Genet 39 46 2002
  • Clinical and genetic analysis of four Mexican families with spinocerebellar ataxia type 10.
    Rasmussen A., Ruano L., Matsuura T., Ochoa A., Yescas P., Alonso E., Ashizawa T.
    Ann Neurol 50(2) 234-239 2001
  • Alcohol dehydrogenase polymorphism and Parkinson's disease.
    Tan E.K., Matsuura T., Nagamitsu S., Jankovic J., Khajavi M., Ashizawa T., Ondo W.
    Neurosci Lett 305(1) 70-72 2001
  • Large expansion of ATTCT pentanucleotide repeat in spinocerebellar ataxia type 10.
    MATSUURA T, YAMAGATA T, RASMUSSEN A, GREWAL R P, WATASE K, ZU L, ACHARI M, ZOGHBI H Y, ASHIZAWA T
    Nat Genet 26(2) 191-194 2000
  • Genetic localization of the CA2+ channel gene Cacng2 near SCA10 on chromosome 22q13.
    Epilepsia 41 24-27 2000
  • Polymorphism of NACP-Rep 1 in Parkinson’s disease: An etiologic link with essential tremor?
    Neurology 54 1195-1198 2000
  • Paroxysmal kinesigenic dyskinesia and infantile convulsions: clinical and linkage studies.
    Neurology 55 224-230 2000
  • A “dystrophic” variant of autosomal recessive myotonia congenita caused by novel mutations in the CLCN1 gene.
    Neurology 55 1697-1703 2000
  • Mapping of the gene for a novel spinocerebellar ataxia with pure cerebellar signs and epilepsy.
    Matsuura T., Khajavi M., Achari M., Zoghbi H.Y., Bachinski L.L., Ashizawa T.
    Ann Neurol 45(3) 407-411 1999
  • Mosaicism of unstable CAG repeats in the brain of spinocerebellar ataxia type 2.
    MATSUURA T, SASAKI H, YABE I, HAMADA K, HAMADA T, SHITARA M, TASHIRO K
    J Neurol 246(9) 835-839 1999
  • Atypical MR findings in Wilson disease: marked lesions in the dentate nucleus causing tremor.
    J Neurol Neurosurg Psychiatry 64 160 1998
  • SCA6 mutation analysis in the large cohort with late-onset pure cerebellar ataxia.
    YABE I, SASAKI H, MATSUURA T, TAKADA A, WAKISAKA A, SUZUKI Y, FUKAZAWA T, HAMADA T, ODA T, OHNISHI A, TASHIRO K
    J Neurol Sci 156(1) 89-95 1998
  • Suatained release dosage of thyrotropin-releasing hormone improves experimental Japanese encephalitis virus-induced parkinsonism rats.
    OGATA A, NAGASHIMA K, YASUI K, MATSUURA T, TASHIRO K
    J Neurol Sci 159(2) 135-139 1998
  • The reduction of androgen receptor mRNA in motoneurons of X-linked spinal and bulbar muscualr atrophy.
    NAKAMURA M, MITA S, MATUURA T, NAGASHIMA K, TANAKA H, ANDO M, UCHINO M
    J Neurol Sci 150(2) 161-165 1997
  • Autosomal dominant spastic paraplegia linked to chromosome 2p: clinical and genetic studies of a large Japanese pedigree.
    MATSUURA T, SASAKI H, WAKISAKA A, HAMADA T, MORIWAKA F, TASHIRO K
    J Neurol Sci 151(1) 65-70 1997
  • CAG repeat expansion of Machado-Joseph disease in the Japanese: analysis of the repeat instability for parental transmission, and correlation with disease phenotype.
    J Neurol Sci 133 28-133 1995
  • Unusual complications caused by endo-clip migration following a laparoscopic cholecystectomy: report of a case.
    SATO T, DENNO R, YUYAMA Y, MATSUURA T, KANISAWA Y, HIRATA K
    Surg Today 24(4) 360-362 1994
  • Expression of androgen receptor in X-linked spinal and bulbar muscular atrophy and amyotrophic lateral sclerosis.
    J Neurol Neurosurg Psychiatry 57 1274-1275 1994
  • Identification of androgen receptor in the rat spinal motoneurons, immunohistochemical and immunoblotting analyses with monoclonal antibody.
    MATSUURA T, OGATA A, DEMURA T, MORIWAKA F, TASHIRO K, KOYANAGI T, NAGASHIMA K
    Neurosci Lett 158(1) 5-8 1993
  • Migartion of “endo-clips” into common bile duct after laparoscopic cholecystectomy.
    Lancet 340 306 1992
  • Minocycline-related lupus
    Lancet 340 1553 1992
  • Androgen receptor abnormality in X-linked spinal and bulbar muscular atrophy.
    Neurology 42 1724-1726 1992
  • A case of Kennedy-Alter-Sung syndrome with type IIa hyperlipidemia. (*corresponding author); Study on sex hormone receptor and lipid metabolism.
    31 291-295 1991

Book

  • SCA10の分子遺伝学.
    神経研究の進歩 2006
  • 非翻訳領域リピート病のRNA病態.
    Medical Science Digest 2006
  • Spinocerebellar Ataxia Type 10 in: GeneReviews at GeneTests: Medical Genetics Information Resource.
    Copyright, University of Washington, Seattle. 1997-2006. Available at http://www.genetests.org. 2006
  • Spinocerebellar Ataxia Type 10 in: /GeneReviews /at GeneTests: Medical Genetics Information Resource.
    Copyright, University of Washington, Seattle. 1997-2004. Available at www.genetests.org . 2004
  • Spinocerebellar Ataxia Type 10 in: /GeneReviews /at GeneTests: Medical Genetics Information Resource.
    Copyright, University of Washington, Seattle. 1997-2002. Available at www.genetests.org . 2002
  • Spinocerebellar Ataxia Type 10: A Disease Caused by a Large ATTCT Repeat Expansion. In: Trinucleotide Expansions and Human Diseases.
    Timchenko L ed. Landes Bioscience, Georgetown 2002
  • Spinocerebellar ataxia type 10: a disease caused by a large ATTCT repeat expansion.
    Adv Exp Med Biol 2002
  • SCA10遺伝子の同定―新しいリピート (pentanucleotide repeat) 病.
    臨床神経学 2001
  • Spinocerebellar ataxia type 10. In: Genetics of Movement Disorders.
    Pulst SM ed. Academic Press, San Diego 2001
  • A glycoprotein detected with peanut agglutin: a specific marker of myelin and human lymphocyte lines. In: Japan intractable diseases research foundation publication No.26 Neuroimmunological diseases, recent in pathogenesis and treatment
    Igata A ed., University of Tokyo Press, Tokyo 1989
Display all
Bookclose
  • SCA10の分子遺伝学.
    神経研究の進歩 2006
  • 非翻訳領域リピート病のRNA病態.
    Medical Science Digest 2006
  • Spinocerebellar Ataxia Type 10 in: GeneReviews at GeneTests: Medical Genetics Information Resource.
    Copyright, University of Washington, Seattle. 1997-2006. Available at http://www.genetests.org. 2006
  • Spinocerebellar Ataxia Type 10 in: /GeneReviews /at GeneTests: Medical Genetics Information Resource.
    Copyright, University of Washington, Seattle. 1997-2004. Available at www.genetests.org . 2004
  • Spinocerebellar Ataxia Type 10 in: /GeneReviews /at GeneTests: Medical Genetics Information Resource.
    Copyright, University of Washington, Seattle. 1997-2002. Available at www.genetests.org . 2002
  • Spinocerebellar Ataxia Type 10: A Disease Caused by a Large ATTCT Repeat Expansion. In: Trinucleotide Expansions and Human Diseases.
    Timchenko L ed. Landes Bioscience, Georgetown 2002
  • Spinocerebellar ataxia type 10: a disease caused by a large ATTCT repeat expansion.
    Adv Exp Med Biol 2002
  • SCA10遺伝子の同定―新しいリピート (pentanucleotide repeat) 病.
    臨床神経学 2001
  • Spinocerebellar ataxia type 10. In: Genetics of Movement Disorders.
    Pulst SM ed. Academic Press, San Diego 2001
  • A glycoprotein detected with peanut agglutin: a specific marker of myelin and human lymphocyte lines. In: Japan intractable diseases research foundation publication No.26 Neuroimmunological diseases, recent in pathogenesis and treatment
    Igata A ed., University of Tokyo Press, Tokyo 1989

Prize

  • 2003 Young Investigator Award, National Ataxia Foundation,
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Prizeclose
  • 2003 Young Investigator Award, National Ataxia Foundation,

Industrial Property Rights

  • DNA TEST FOR SCA-10

Works

  • Research Grants from National Ataxia Foundation, MN, USA ($25,000) “The role of interruptions in SCA10 expansion and disease”
    2005-2005
  • Research Grants (Olivopontocerebellar atrophy and related disorders) from NORD ($40,000) “Characterization of the SCA10 ATTCT Expansion and Implications of the Sequence Configurations”
    2005-2005
  • Young Investigator Award from National Ataxia Foundation, MN, USA  ($100,000) “RNA disease mechanism in spinocerebellar ataxia type 10”
    2003-2004
  • Research Grants (Olivopontocerebellar atrophy and related disorders) from National Organization for Rare Disorders (NORD), CT, USA ($40,000) “Complete survey of SCA10 mutation in multiethnic ataxia patients”
    2003-2004
  • Research Grants from National Ataxia Foundation, MN, USA ($30,000) “Search for an expansion mutation of ATTCT/AGAAT repeats in unassigned ataxia patients”
    2002-2002
  • Research Grants from National Ataxia Foundation, MN, USA ($10,000) “Instability of the expanded SCA10 ATTCT pentanucleotide repeat ”
    2001-2001
Display all
Worksclose
  • Research Grants from National Ataxia Foundation, MN, USA ($25,000) “The role of interruptions in SCA10 expansion and disease”
    2005-2005
  • Research Grants (Olivopontocerebellar atrophy and related disorders) from NORD ($40,000) “Characterization of the SCA10 ATTCT Expansion and Implications of the Sequence Configurations”
    2005-2005
  • Young Investigator Award from National Ataxia Foundation, MN, USA  ($100,000) “RNA disease mechanism in spinocerebellar ataxia type 10”
    2003-2004
  • Research Grants (Olivopontocerebellar atrophy and related disorders) from National Organization for Rare Disorders (NORD), CT, USA ($40,000) “Complete survey of SCA10 mutation in multiethnic ataxia patients”
    2003-2004
  • Research Grants from National Ataxia Foundation, MN, USA ($30,000) “Search for an expansion mutation of ATTCT/AGAAT repeats in unassigned ataxia patients”
    2002-2002
  • Research Grants from National Ataxia Foundation, MN, USA ($10,000) “Instability of the expanded SCA10 ATTCT pentanucleotide repeat ”
    2001-2001


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