KAWAKAMI Kiyoshi

FacultyDivisionofBiology
Job titleProfessorWeb site

Profile

Research Keywords

    Sp1, Six1, Six4, Sp3, Six, Eya, Na,K-ATPase, Dach, Transcriptional Regulation, Molecular Pathology

Research Areas

  • Basic medicine / General medical chemistry
  • Clinical surgery / Otorhinolaryngology
  • Basic medicine / Pathological medical chemistry
  • Basic medicine / General physiology
  • Cerebral Neuroscience / Neuroscience in general
  • Clinical internal medicine / Cardiovascular medicine
  • Clinical internal medicine / Kidney internal medicine
  • Biological science / Molecular biology
  • Biological science / Developmental biology
  • Basic medicine / General anatomy (including histology/embryology)
  • Basic medicine / General physiology
  • Basic medicine / Pathological medical chemistry

Career

  • Jichi Medical University, Professor.

Research Activities

Papers(paper)

  • Effects of ouabain on respiratory rhythm generation in brainstem-spinal cord preparation from newborn rats and in decerebrate and arterially perfused in situ preparation from juvenile rats.
    Tsuzawa, K., Yazawa, I., Shakuo, T., Ikeda, K., Kawakami, K.
    Neuroscience 286 404-411 Jan. 2015
  • Heterozygous mice deficient in Atp1a3 exhibit motor deficits by chronic restraint stress.
    Sugimoto H, Ikeda K, Kawakami K
    Behavioural brain research 272 100-110 Oct. 2014
  • FGFR1-Frs2/3 signalling maintains sensory progenitors during inner ear hair cell formation.
    Ono K, Kita T, Sato S, O'Neill P, Mak SS, Paschaki M, Ito M, Gotoh N, Kawakami K, Sasai Y, Ladher RK
    PLoS genetics 10 e1004118 Jan. 2014
  • Cytoarchitecture and CO2 Sensitivity of Phox2b-Positive Parafacial Neurons in the Newborn Rat Medulla.
    Onimaru H, Ikeda K, Mariho T, Kawakami K
    Progress in brain research 209 57-71 2014
  • Homeoproteins Six1 and Six4 regulate male sex determination and mouse gonadal development.
    Fujimoto Y, Tanaka SS, Yamaguchi YL, Kobayashi H, Kuroki S, Tachibana M, Shinomura M, Kanai Y, Morohashi K, Kawakami K, Nishinakamura R
    Developmental cell 26 416-430 Aug. 2013
  • Enhanced inhibitory neurotransmission in the cerebellar cortex of Atp1a3-deficient heterozygous mice.
    Ikeda K, Satake S, Onaka T, Sugimoto H, Takeda N, Imoto K, Kawakami K
    The Journal of physiology 591 3433-3449 Jul. 2013
  • Regulation of Six1 expression by evolutionarily conserved enhancers in tetrapods.
    Sato S, Ikeda K, Shioi G, Nakao K, Yajima H, Kawakami K
    Developmental biology 368 95-108 Aug. 2012
  • Postsynaptic mechanisms of CO(2) responses in parafacial respiratory neurons of newborn rats.
    Onimaru H, Ikeda K, Kawakami K
    The Journal of physiology 590 1615-1624 Apr. 2012
  • Development of gustatory papillae in the absence of Six1 and Six4.
    Suzuki Y, Ikeda K, Kawakami K
    Journal of anatomy 219 710-721 Dec. 2011
  • Menthol inhibits the respiratory rhythm in brainstem preparations of the newborn rats.
    Tani M, Onimaru H, Ikeda K, Kawakami K, Homma I
    Neuroreport 21 1095-1099 Dec. 2010
Display all
Papers(paper)close
  • Effects of ouabain on respiratory rhythm generation in brainstem-spinal cord preparation from newborn rats and in decerebrate and arterially perfused in situ preparation from juvenile rats.
    Tsuzawa, K., Yazawa, I., Shakuo, T., Ikeda, K., Kawakami, K.
    Neuroscience 286 404-411 Jan. 2015
  • Heterozygous mice deficient in Atp1a3 exhibit motor deficits by chronic restraint stress.
    Sugimoto H, Ikeda K, Kawakami K
    Behavioural brain research 272 100-110 Oct. 2014
  • FGFR1-Frs2/3 signalling maintains sensory progenitors during inner ear hair cell formation.
    Ono K, Kita T, Sato S, O'Neill P, Mak SS, Paschaki M, Ito M, Gotoh N, Kawakami K, Sasai Y, Ladher RK
    PLoS genetics 10 e1004118 Jan. 2014
  • Cytoarchitecture and CO2 Sensitivity of Phox2b-Positive Parafacial Neurons in the Newborn Rat Medulla.
    Onimaru H, Ikeda K, Mariho T, Kawakami K
    Progress in brain research 209 57-71 2014
  • Homeoproteins Six1 and Six4 regulate male sex determination and mouse gonadal development.
    Fujimoto Y, Tanaka SS, Yamaguchi YL, Kobayashi H, Kuroki S, Tachibana M, Shinomura M, Kanai Y, Morohashi K, Kawakami K, Nishinakamura R
    Developmental cell 26 416-430 Aug. 2013
  • Enhanced inhibitory neurotransmission in the cerebellar cortex of Atp1a3-deficient heterozygous mice.
    Ikeda K, Satake S, Onaka T, Sugimoto H, Takeda N, Imoto K, Kawakami K
    The Journal of physiology 591 3433-3449 Jul. 2013
  • Regulation of Six1 expression by evolutionarily conserved enhancers in tetrapods.
    Sato S, Ikeda K, Shioi G, Nakao K, Yajima H, Kawakami K
    Developmental biology 368 95-108 Aug. 2012
  • Postsynaptic mechanisms of CO(2) responses in parafacial respiratory neurons of newborn rats.
    Onimaru H, Ikeda K, Kawakami K
    The Journal of physiology 590 1615-1624 Apr. 2012
  • Development of gustatory papillae in the absence of Six1 and Six4.
    Suzuki Y, Ikeda K, Kawakami K
    Journal of anatomy 219 710-721 Dec. 2011
  • Menthol inhibits the respiratory rhythm in brainstem preparations of the newborn rats.
    Tani M, Onimaru H, Ikeda K, Kawakami K, Homma I
    Neuroreport 21 1095-1099 Dec. 2010
  • Expression of Six1 and Six4 in mouse taste buds.
    Suzuki Y, Ikeda K, Kawakami K
    Journal of molecular histology 41 205-214 Oct. 2010
  • Six family genes control the proliferation and differentiation of muscle satellite cells.
    Yajima H, Motohashi N, Ono Y, Sato S, Ikeda K, Masuda S, Yada E, Kanesaki H, Miyagoe-Suzuki Y, Takeda S, Kawakami K
    Experimental cell research 316 2932-2944 Oct. 2010
  • Conserved expression of mouse Six1 in the pre-placodal region (PPR) and identification of an enhancer for the rostral PPR.
    Sato S, Ikeda K, Shioi G, Ochi H, Ogino H, Yajima H, Kawakami K
    Developmental biology 344 158-171 Aug. 2010
  • Regulatory role of Six1 in the development of taste papillae.
    Suzuki Y, Ikeda K, Kawakami K
    Cell and tissue research 339 513-525 Mar. 2010
  • Characterization of the Six1 homeobox gene in normal mammary gland morphogenesis.
    Coletta RD, McCoy EL, Burns V, Kawakami K, McManaman JL, Wysolmerski JJ, Ford HL
    BMC developmental biology 10 4 Jan. 2010
  • Phox2b expressing neurons in the most rostral medulla of newborn rats.
    Onimaru H, Ikeda K, Kawakami K
    Advances in experimental medicine and biology 669 87-90 2010
  • Six1 is indispensable for production of functional progenitor cells during olfactory epithelial development.
    Ikeda K, Kageyama R, Suzuki Y, Kawakami K
    The International journal of developmental biology 54 1453-1464 2010
  • Phox2b, RTN/pFRG neurons and respiratory rhythmogenesis.
    Onimaru H, Ikeda K, Kawakami K
    Respiratory physiology & neurobiology 168 13-18 Aug. 2009
  • CO2-sensitive preinspiratory neurons of the parafacial respiratory group express Phox2b in the neonatal rat.
    Onimaru H, Ikeda K, Kawakami K
    The Journal of neuroscience : the official journal of the Society for Neuroscience 28 12845-12850 Nov. 2008
  • Multiple evolutionarily conserved enhancers control expression of Eya1.
    Ishihara T, Sato S, Ikeda K, Yajima H, Kawakami K
    Developmental dynamics : an official publication of the American Association of Anatomists 237 3142-3156 Nov. 2008
  • Differential expression of Eya1 and Eya2 during chick early embryonic development.
    Ishihara T, Ikeda K, Sato S, Yajima H, Kawakami K
    Gene expression patterns : GEP 8 357-367 May 2008
  • Six1 is essential for early neurogenesis in the development of olfactory epithelium.
    Ikeda K, Ookawara S, Sato S, Ando Z, Kageyama R, Kawakami K
    Developmental biology 311 53-68 Nov. 2007
  • Regulation of Na,K-ATPase alpha1 subunit gene transcription in response to low K(+): role of CRE/ATF- and GC box-binding proteins.
    Wang G, Kawakami K, Gick G
    Journal of cellular physiology 213 167-176 Oct. 2007
  • Defective interaction between dual oscillators for respiratory rhythm generation in Na+,K+-ATPase {alpha}2 subunit-deficient mice.
    Onimaru H, Ikeda K, Kawakami K
    The Journal of physiology 584 271-284 Oct. 2007
  • Six1 and Six4 are essential for Gdnf expression in the metanephric mesenchyme and ureteric bud formation, while Six1 deficiency alone causes mesonephric-tubule defects.
    Kobayashi H, Kawakami K, Asashima M, Nishinakamura R
    Mechanisms of development 124 290-303 Apr. 2007
  • Divergent signaling pathways mediate induction of Na,K-ATPase alpha1 and beta1 subunit gene transcription by low potassium.
    Wang G, Kawakami K, Gick G
    Molecular and cellular biochemistry 294 73-85 Jan. 2007
  • Six1 and Six4 promote survival of sensory neurons during early trigeminal gangliogenesis.
    Konishi Y, Ikeda K, Iwakura Y, Kawakami K
    Brain research 1116 93-102 Oct. 2006
  • Transcriptional activation of the SALL1 by the human SIX1 homeodomain during kidney development.
    Chai L, Yang J, Di C, Cui W, Kawakami K, Lai R, Ma Y
    The Journal of biological chemistry 281 18918-18926 Jul. 2006
  • Hyperphagia and obesity in Na,K-ATPase alpha2 subunit-defective mice.
    Kawakami K, Onaka T, Iwase M, Homma I, Ikeda K
    Obesity research 13 1661-1671 Oct. 2005
  • Slc12a2 is a direct target of two closely related homeobox proteins, Six1 and Six4.
    Ando Z, Sato S, Ikeda K, Kawakami K
    The FEBS journal 272 3026-3041 Jun. 2005
  • [Novel function of sodium pump].
    Ikeda K, Onimaru H, Kawakami K
    Tanpakushitsu kakusan koso. Protein, nucleic acid, enzyme 50 434-439 May 2005
  • Malfunction of respiratory-related neuronal activity in Na+, K+-ATPase alpha2 subunit-deficient mice is attributable to abnormal Cl- homeostasis in brainstem neurons.
    Ikeda K, Onimaru H, Yamada J, Inoue K, Ueno S, Onaka T, Toyoda H, Arata A, Ishikawa TO, Taketo MM, Fukuda A, Kawakami K
    The Journal of neuroscience : the official journal of the Society for Neuroscience 24 10693-10701 Nov. 2004
  • Six1 controls patterning of the mouse otic vesicle.
    Ozaki H, Nakamura K, Funahashi J, Ikeda K, Yamada G, Tokano H, Okamura HO, Kitamura K, Muto S, Kotaki H, Sudo K, Horai R, Iwakura Y, Kawakami K
    Development (Cambridge, England) 131 551-562 Feb. 2004
  • Degeneration of the amygdala/piriform cortex and enhanced fear/anxiety behaviors in sodium pump alpha2 subunit (Atp1a2)-deficient mice.
    Ikeda K, Onaka T, Yamakado M, Nakai J, Ishikawa TO, Taketo MM, Kawakami K
    The Journal of neuroscience : the official journal of the Society for Neuroscience 23 4667-4676 Jun. 2003
  • Molecular interaction and synergistic activation of a promoter by Six, Eya, and Dach proteins mediated through CREB binding protein.
    Ikeda K, Watanabe Y, Ohto H, Kawakami K
    Molecular and cellular biology 22 6759-6766 Oct. 2002
  • Identification of transcriptional targets for Six5: implication for the pathogenesis of myotonic dystrophy type 1.
    Sato S, Nakamura M, Cho DH, Tapscott SJ, Ozaki H, Kawakami K
    Human molecular genetics 11 1045-1058 May 2002
  • Impaired interactions between mouse Eyal harboring mutations found in patients with branchio-oto-renal syndrome and Six, Dach, and G proteins.
    Ozaki H, Watanabe Y, Ikeda K, Kawakami K
    Journal of human genetics 47 107-116 2002
  • Knockout of sodium pump α3 subunit gene (Atp1a3-/-) results in perinatal seizure and defective respiratory rhythm generation.
    Ikeda K, Onimaru H, Kawakami K
    Brain research 1666 27-37 Jul. 2017
  • Distinctive features of Phox2b-expressing neurons in the rat reticular formation dorsal to the trigeminal motor nucleus.
    Nagoya K, Nakamura S, Ikeda K, Onimaru H, Yoshida A, Nakayama K, Mochizuki A, Kiyomoto M, Sato F, Kawakami K, Takahashi K, Inoue T
    Neuroscience 358 211-226 Jul. 2017
  • Effects of a TRPV1 agonist capsaicin on respiratory rhythm generation in brainstem-spinal cord preparation from newborn rats.
    Tani M, Kotani S, Hayakawa C, Lin ST, Irie S, Ikeda K, Kawakami K, Onimaru H
    Pflugers Archiv : European journal of physiology 469(2) 327-338 Feb. 2017
  • The respiratory control mechanisms in the brainstem and spinal cord: integrative views of the neuroanatomy and neurophysiology.
    Ikeda K, Kawakami K, Onimaru H, Okada Y, Yokota S, Koshiya N, Oku Y, Iizuka M, Koizumi H
    The journal of physiological sciences : JPS 67(1) 45-62 Jan. 2017
  • Low Six4 and Six5 gene dosage improves dystrophic phenotype and prolongs life span of mdx mice.
    Yajima H, Kawakami K
    Development, growth & differentiation 58(6) 546-561 Aug. 2016
  • Six1 is required for mouse dental follicle cell and human periodontal ligament-derived cell proliferation.
    Kawasaki T, Takahashi M, Yajima H, Mori Y, Kawakami K
    Development, growth & differentiation 58(6) 530-545 Aug. 2016
  • Long-lasting facilitation of respiratory rhythm by treatment with TRPA1 agonist, cinnamaldehyde.
    Tani M, Yazawa I, Ikeda K, Kawakami K, Onimaru H
    Journal of neurophysiology 114(2) 989-998 Aug. 2015
  • A Phox2b BAC Transgenic Rat Line Useful for Understanding Respiratory Rhythm Generator Neural Circuitry.
    Ikeda K, Takahashi M, Sato S, Igarashi H, Ishizuka T, Yawo H, Arata S, Southard-Smith EM, Kawakami K, Onimaru H
    PloS one 10(7) e0132475 2015
  • Activation of Six1 Expression in Vertebrate Sensory Neurons.
    Sato S, Yajima H, Furuta Y, Ikeda K, Kawakami K
    PloS one 10(8) e0136666 2015

Papers(other)

  • Primary structure of the α-subunit of ┣DBTorpedo(/)-┫DB ┣DBcalifomica(/)-┫DB (Na++K+) ATPase deduced from cDNA sequence.
    Nature 316 1985
  • Iedentitication andpurification of a human immunoglobulin-enhancer-binding protein (NF-KB) that activates transcription from a human immunodeficiency virus type 1 promoter ┣DBin vitro(/)-┫DB.
    Proceedings of National Academy of Science. USA 85 1988
  • A human lymphoid-specific transcription factor that activates immunoglobulin gens is a homeobox protein
    Nature 336 1988
  • Housekeeping Na, K-ATPase α1 Subunit gene promoter is composed of multiple cis-elements to which common and cell type specific factors bind
    Molecular and Cellular Biology 12 1992
  • Location of signal sequences for membrone insertion of the Na+, K+-ATPase α-subunit
    Molecular and Cellular Biology 9 1989
  • Identification and characterization of the cis-elements regulating the rat AMOG (Adhesion Molecule on Glia)/Na, K-ATPase β2 subunit gene)
    Journal of Biochemistry 111 1992
  • Cloning and analysis of 5'-flanking region of rat Na+/K+-ATPase α1 subunit gene
    Biochimica Biophysica Acta 1049 1990
  • Regulation of Na+, K+-ATPAase I Cloning and analysis of the 5'-flanking region of the rat NKAA2 gene encoding α2 subunit
    Gene 91 1990
  • Regulation of Na+, K+-ATPases II. Cloning and analysis of the 5'-flanking region of the rat NKAB2 gene encoding β2 subunit
    Gene 91 1990
  • The transmembrane segment of human Na, K-ATPase β-subunit acts as the membrane insertion signal.
    J. Biochmistry 103 1988
Display all
Papers(other)close
  • Primary structure of the α-subunit of ┣DBTorpedo(/)-┫DB ┣DBcalifomica(/)-┫DB (Na++K+) ATPase deduced from cDNA sequence.
    Nature 316 1985
  • Iedentitication andpurification of a human immunoglobulin-enhancer-binding protein (NF-KB) that activates transcription from a human immunodeficiency virus type 1 promoter ┣DBin vitro(/)-┫DB.
    Proceedings of National Academy of Science. USA 85 1988
  • A human lymphoid-specific transcription factor that activates immunoglobulin gens is a homeobox protein
    Nature 336 1988
  • Housekeeping Na, K-ATPase α1 Subunit gene promoter is composed of multiple cis-elements to which common and cell type specific factors bind
    Molecular and Cellular Biology 12 1992
  • Location of signal sequences for membrone insertion of the Na+, K+-ATPase α-subunit
    Molecular and Cellular Biology 9 1989
  • Identification and characterization of the cis-elements regulating the rat AMOG (Adhesion Molecule on Glia)/Na, K-ATPase β2 subunit gene)
    Journal of Biochemistry 111 1992
  • Cloning and analysis of 5'-flanking region of rat Na+/K+-ATPase α1 subunit gene
    Biochimica Biophysica Acta 1049 1990
  • Regulation of Na+, K+-ATPAase I Cloning and analysis of the 5'-flanking region of the rat NKAA2 gene encoding α2 subunit
    Gene 91 1990
  • Regulation of Na+, K+-ATPases II. Cloning and analysis of the 5'-flanking region of the rat NKAB2 gene encoding β2 subunit
    Gene 91 1990
  • The transmembrane segment of human Na, K-ATPase β-subunit acts as the membrane insertion signal.
    J. Biochmistry 103 1988
  • Sp1 binds to the Adhesion Molecule on Glia regulatory element that functions as a positive transcription regulatory element in astrocytes. (jointly worked)
    Journal of Neuroscience Research 35,138-146 1993
  • Regulation of Na, K-adenosine triphosphatase gene expression by sodium ions in cultured neonatal rat cardiocytes. (jointly worked)
    Journal of Clinical Investigation 92,1889-1895 1993
  • Thyroid hormone stimulates Na+-K+-ATPase gene expression in cultured rat mesangial cells. (jointly worked)
    American Journal of Physiology 265,F370-F376 1993
  • Regulation of Na, K-ATPase gene expression by aldosterone in vascular smooth muscle cells. (jointly worked)
    American Journal of Physiology 265,H1167-1172 1993
  • Altered Na, K-ATPase mRNA expression in spontaneously hypertensive rats. (jointly worked)
    Hypertension Research 16,269-274 1993
  • Anomalous interaction of Sp1 and specific binding of an E-box-binding protein with the regulatory elements of the Na, K-ATPase α2 subunit gene promoter. (jointly worked)
    European Journal of Biochemistry 218,195-204 1993
  • Possible implications of Sp1-induced bending of DNA on synergistic activation of transcription. (jointly worked)
    Gene 136,341-343 1993
  • Transcription factors positively and negatively regulating the Na, K-ATPase α1 subunit gene. (jointly worked)
    Journal of Biochemistry 114,849-855 1993
  • Different factors bind to the regulatory region of Na+, K+-ATPase α1 subunit gene in cell cycle. (jointly worked)
    FEBS Letters 335,251-254 1993
  • Stabilization in microsomal membranes of fifth transmembrane segment of Na+, K+-ATPase α subunit with proline to leucine mutation. (jointly worked)
    Biochemistry & Cell Biology 71,410-415 1993
  • "Sodium ion mediated regulation of Na/K-ATPase gene expression in vascular smooth muscle cells. "
    Cardiovascular Res. 28 957-962 1994
  • "The existence of a growth-specific DNA binding factor for the promoter region on mouse ST2 gene. "
    FEBS Lett. 354(3) 311-314 1994
  • ATF-1/CREB heterodimer is involved in constitutive constitutive expression of the housekeeping Na, K-ATPase α1 subunit gene
    Nucl.Acids Res 23(15) 2848-2855 1995
  • DNA binding through distinct domains of zinc-fingerhomeodomain protein AREB6 has different effects on gene transcription
    Eur.J.Biochem 233(1) 73-82 1995
  • Structure, function and expression of a murine homebox protein AREC3, a homelogue of Drosophila sine oculis gene product, and implication in development
    Nucl.Acids Res 24(2) 303-310 1996
  • Differential regulation of Na+-K+-ATPase gene expression by corticosteroids in vascular smooth muscle cells
    Am.J.Physiol(270) C731-C739 1996
  • Hyperosmolarity stimulates Na,K-APTase gene expression in inner medullaty collecting duct cells
    Am.J.Phys(270) F728-F738 1996
  • Characterrization of the core promoter of the Na+/K+-ATPase α2 subunit gene : Elements required for transcription by RNA polymerase II and III in vitro
    Eur.J.Biochem 237(2) 440-446 1996
  • Cis-elements involved in differential expression of Na,K-ATPase α2 subunit gene in muscle differentiation
    Biochim.Biophys.Acta.(1308) 67-73 1996
  • "Identification and expression of sixfamily genes in mouse retina" (jointly worked)
    FEBS Lett. 393(2/3) 259-263 1996
  • "Phosphorylation of ATF-1 enhances its DNA binding and transcription of the Na, K-ATPase α1 subunit gene promoter" (jointly worked)
    Nucl. Acids Res. 25(4) 877-882 1997
  • "Impairment of T cell development in δEF1 mutant mice" (jointly worked)
    J. Exp. Med. 185(8) 1467-1479 1997
  • "Promoter of the Na, K-ATPase α3 subunit gene is composed of cis elements to which NF-Y and Sp1/Sp3 bind in cardiac myocyte." (jointly worked)
    Biochim. Biophys. 1352 311-324 1997
  • Serum transcriptionally regulates Na, K-ATP ase gene expression in vascular smooth muscle cells. (jointly worked)
    Am. J. Phys. 273 C1088-C1099 1997
  • In vivo footprinting analysis of the Na, K-ATPase α3 subunit gene promoter in rat cardiocytes. (jointly worked)
    Jichi Medical School J. 20 35-43 1997
  • Synergism of the ATF/CRE site and GC box in the housekeeping Na, K-ATPase α1 subunit gene is essential for constitutive expression. (jointly worked)
    Biochem. Biophys. Res. Comm. 241(1) 169-174 1997
  • Involvement of negative co-factor NC2 in active repression by zinc-finger-homeodomain transcription factor AREB6. (jointly worked)
    Molec. Cell. Biol. 18 10-18 1998
  • Regulation of Na-K-ATPase gene expression by hyperoxia in MDCK cells. (jointly worked)
    Am. J. Phys. 274 C356-364 1998
  • Dominant negative ATF1 blocks cAMP-induced neurite outgrowth in PC12D cells. (jointly worked)
    J. Neurochem. 70 1029-1034 1998
  • Tissue and developmental distribution of Six family gene products. (jointly worked)
    Int. J. Dev. Biol. 42 141-148 1998
  • Transcriptional regulation of Na, K-ATPase gene expression by hyperosmolality in vascular smooth muscle cells. (jointly worked)
    J. Membr. Biol. 162 233-245 1998
  • Corticosterone and it's metabolite, 11-dehydrocorticosterone, stimulate Na, K-ATPase gene expression in vascular smooth muscle cells. (jointly worked)
    Kidney International 54 492-508 1998
  • Overexpression of the forebrain-specific homeobox gene six3 induces rostral forebrain enlargement in zebrafish. (jointly worked)
    Development 125 2973-2982 1998
  • "Promoter of mDMA HP/Six5 : differential utilization of multiple transcription initiation sites and positive/negative regulatory elements. "
    Hum. Molec. Genet. 7 2103-2112 1998
  • "Localization of Six4/AREC3 in the developing retina ; implications in mammalian retinal development. "
    Exp. Eye Res. 67 699-707 1998
  • "Cooperation of Eya and Six in transactivation of thier target genes through nuclear translocation of Eya. "
    Molec. Cell. Biol. 19 6815-6824 1999
  • Structure and chromosomal mapping of human SIX4 and mouse Six4 genes. (jointly worked)
    Cytogenet. Cell Genet. 87 108-122 1999
  • Intracellular Na+ directly modulates Na+, K+-ATPase gene expression in normal rat kidney epithelial cells. (jointly worked)
    Kidney Int., 57 1617-1635 2000
  • Six family genes-Structure and function as transcription factors and their roles in development. (jointly worked)
    BioEssays 22 616-626 2000
  • "Expression of three zebrafish Six4 genes in the cranial sensory placodes and the developing somites"
    Mech. Dev. 98 151-155 2000
  • "Six4, a putative myogenin gene regulator, is not essential for mouse embryonal development"
    Mol. Cell. Biol. 21(10) 3343-3350 2001
  • Impaired interactions between mouse Eya1 harboring mutations found in patients with branchio-oto-renal syndrome and Six, Dach and G proteins.
    J. Hum. Genet. 4 47, 107-116. 2002
  • Identification of transcriptional targets for Six5: Implication for the pathogenesis of myotonic dystrophy type 1. H
    Hum. Mol. Genet.. 1 11, 1045-1058 2002
  • Molecular interaction and synergistic activation of a promoter by Six, Eya and Dach proteins mediated through CBP.
    Mol. Cell. Biol. 2 22, 6759-6766. 2002
  • Six and Eya expression during human somitogenesis and MyoD gene family activation. J
    J. Muscle Res. Cell Motil. 2 223, 255-264 2002
  • Degeneration of the amygdala/piriform cortex and enhanced fear/anxiety behaviors in sodium pump a2 subunit (Atp1a2) deficient mice.
    J.Neurosci. 23, 4667-46 2003
  • Six1 controls patterning of the mouse otic vesicle
    Development in press 2003
  • Six1 and Eya1 expression can reprogram adult muscle from the slow-twitch phenotype into the fast-twitch phenotype.
    Mol. Cell. Biol. 24(14) 6253-6267 2004
  • Malfunction of respiratory related neuronal activity in Na+, K+-ATPase α2 subunit-deficient mice is due to abnormal Cl- homeostasis in brainstem neurons.
    Ikeda, K., Onimaru, H., Yamada, J., Inoue, K., Ueno, S., Onaka, T., Toyoda, H., Arata, A., Ishikawa, T., Taketo, M. M., Fukuda, A. and Kawakami, K.
    J. Neurosci. 24 10693 2004
  • Slc12a2 is a direct target of two closely related homeobox proteins, Six1 and Six4.
    89. Ando, Z., Sato, S., Ikeda, K. and Kawakami, K.
    FEBS J. 272(12) 3026-3041 2005
  • Hyperphagia and obesity in Na,K-ATPase α2 subunit defective mice.
    Kawakami, K., Onaka, T., Iwase, M., Homma, I. and Ikeda, K.
    Obesity Res. 13 1661 2005
  • Transcriptional activation of the SALL1 by the human SIX1 homeodomain during kidney development.
    Chai, L., Yang, J., Di, C., Cui, W., Kawakami, K., Lai, R. and Ma, Y.
    J. Biol. Chem. 281(28) 18918-18926 2006
  • Six1 and Six4 promote survival of sensory neurons during early trigeminal gangliogenesis.
    Konishi, Y., Ikeda, K., Iwakura, Y. and Kawakami, K.
    Brain Res. 1116 93 2006
  • Divergent signaling pathways mediate induction of Na,K-ATPase α1 and β1 subunit gene transcription by low potassium.
    Wang, G., Kawakami, K. and Gick, G.
    Mol. Cell. Biochem. 294(1-2) 73-85 2006
  • Modulation of neural activities by Na,K-ATPase α2 subunit through functional coupling with transporters.
    Kawakami, K. and Ikeda, K.
    Cell. Mol. Biol. 52 92 2006

Book

  • "Transcription factors regulating the Na+/K+-ATPase genes"
    In The Sodium Pump : Structure mechanism, hormonal control and its role in disease. 1994
  • "Spl and an E-box binding protein regulate Na+/K+-ATPase α2 subunit gene. "
    In The Sodium Pump : Structure mechanism, hormonal control and its role in disease. 1994
  • "Transcriptional regulation of Na, K-ATPase alphal subunit gene"
    "Control and diseases of sodium dependent transport proteins and ion channel" 2000
Display all
Bookclose
  • "Transcription factors regulating the Na+/K+-ATPase genes"
    In The Sodium Pump : Structure mechanism, hormonal control and its role in disease. 1994
  • "Spl and an E-box binding protein regulate Na+/K+-ATPase α2 subunit gene. "
    In The Sodium Pump : Structure mechanism, hormonal control and its role in disease. 1994
  • "Transcriptional regulation of Na, K-ATPase alphal subunit gene"
    "Control and diseases of sodium dependent transport proteins and ion channel" 2000

Outside Fund Adoption

  • Physiological function of Na pumpα3 subunit gene and involvement in pathophysiology of dystonia parkinsonism.
    Ministry of Education, Culture, Sports, Science and Technology:Grants-in-Aid for Scientific Research(基盤研究(C))
    Project Year :2009 - 2011 Investigator(s) : Kiyoshi KAWAKAMI
  • Principle of organogenesis derived from neural crest cells
    Ministry of Education, Culture, Sports, Science and Technology:Grants-in-Aid for Scientific Research(基盤研究(B))
    Project Year :2006 - 2008 Investigator(s) : Kiyoshi KAWAKAMI
  • Developmental Program and Genetic Disease by Six family genes.
    Ministry of Education, Culture, Sports, Science and Technology:Grants-in-Aid for Scientific Research(基盤研究(B))
    Project Year :2000 - 2002 Investigator(s) : Kiyoshi KAWAKAMI
  • Function of DMAHP/Six5 gene and the involvement in myotonic dystrophy
    Ministry of Education, Culture, Sports, Science and Technology:Grants-in-Aid for Scientific Research(基盤研究(C))
    Project Year :1998 - 1999 Investigator(s) : Kiyoshi KAWAKAMI
  • Regulation of Na, K-ATPase in renal, cardiac, pulmonaly disease
    Ministry of Education, Culture, Sports, Science and Technology:Grants-in-Aid for Scientific Research(国際学術研究)
    Project Year :1995 - 1997 Investigator(s) : Kiyoshi KAWAKAMI
  • Structure and function of the transcription factor AREC3
    Ministry of Education, Culture, Sports, Science and Technology:Grants-in-Aid for Scientific Research(一般研究(C), 基盤研究(C))
    Project Year :1995 - 1996 Investigator(s) : Kiyoshi KAWAKAMI
  • Physiological function of six family genes
  • Physiological Role of Na, K-ATPases
  • Molecular Medicine of Myotonic Dystrophy
  • Molecular pathology of myotonic dystrophy
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  • Physiological function of Na pumpα3 subunit gene and involvement in pathophysiology of dystonia parkinsonism.
    Ministry of Education, Culture, Sports, Science and Technology:Grants-in-Aid for Scientific Research(基盤研究(C))
    Project Year :2009 - 2011 Investigator(s) : Kiyoshi KAWAKAMI
  • Principle of organogenesis derived from neural crest cells
    Ministry of Education, Culture, Sports, Science and Technology:Grants-in-Aid for Scientific Research(基盤研究(B))
    Project Year :2006 - 2008 Investigator(s) : Kiyoshi KAWAKAMI
  • Developmental Program and Genetic Disease by Six family genes.
    Ministry of Education, Culture, Sports, Science and Technology:Grants-in-Aid for Scientific Research(基盤研究(B))
    Project Year :2000 - 2002 Investigator(s) : Kiyoshi KAWAKAMI
  • Function of DMAHP/Six5 gene and the involvement in myotonic dystrophy
    Ministry of Education, Culture, Sports, Science and Technology:Grants-in-Aid for Scientific Research(基盤研究(C))
    Project Year :1998 - 1999 Investigator(s) : Kiyoshi KAWAKAMI
  • Regulation of Na, K-ATPase in renal, cardiac, pulmonaly disease
    Ministry of Education, Culture, Sports, Science and Technology:Grants-in-Aid for Scientific Research(国際学術研究)
    Project Year :1995 - 1997 Investigator(s) : Kiyoshi KAWAKAMI
  • Structure and function of the transcription factor AREC3
    Ministry of Education, Culture, Sports, Science and Technology:Grants-in-Aid for Scientific Research(一般研究(C), 基盤研究(C))
    Project Year :1995 - 1996 Investigator(s) : Kiyoshi KAWAKAMI
  • Physiological function of six family genes
  • Physiological Role of Na, K-ATPases
  • Molecular Medicine of Myotonic Dystrophy
  • Molecular pathology of myotonic dystrophy

Works

  • Physiological function of sodium pump gene
    1996
  • Roles of Six family genes in development
    1996-1998
  • Regulation of Na, K-ATPase in renal cardiac and pulmonary
    1995-1998
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  • Physiological function of sodium pump gene
    1996
  • Roles of Six family genes in development
    1996-1998
  • Regulation of Na, K-ATPase in renal cardiac and pulmonary
    1995-1998


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