KURO-O Makoto

FacultyDivisionofAnti-agingMedicine
Job titleProfessorWeb site

Research Activities

Papers(paper)

  • αKlotho and vascular calcification: an evolving paradigm.
    Hu MC, Kuro-O M, Moe OW
    Current opinion in nephrology and hypertension 23 331-339 Jul. 2014
  • 1,25(OH)2 vitamin D3-dependent inhibition of platelet Ca2+ signaling and thrombus formation in klotho-deficient mice.
    Borst O, Münzer P, Schmid E, Schmidt EM, Russo A, Walker B, Yang W, Leibrock C, Szteyn K, Schmidt S, Elvers M, Faggio C, Shumilina E, Kuro-o M, Gawaz M, Lang F
    FASEB journal : official publication of the Federation of American Societies for Experimental Biology 28 2108-2119 May 2014
  • Fibroblast growth factor 23 and uremic vascular calcification: is it time to escalate from biomarker status to pathogenic agent?
    Moe OW, Kuro-o M
    Kidney international 85 1022-1023 May 2014
  • Life extension factor klotho enhances cognition.
    Dubal DB, Yokoyama JS, Zhu L, Broestl L, Worden K, Wang D, Sturm VE, Kim D, Klein E, Yu GQ, Ho K, Eilertson KE, Yu L, Kuro-O M, De Jager PL, Coppola G, Small GW, Bennett DA, Kramer JH, Abraham CR, Miller BL, Mucke L
    Cell reports 7 1065-1076 May 2014
  • Loss of Memo, a novel FGFR regulator, results in reduced lifespan.
    Haenzi B, Bonny O, Masson R, Lienhard S, Dey JH, Kuro-o M, Hynes NE
    FASEB journal : official publication of the Federation of American Societies for Experimental Biology 28 327-336 Jan. 2014
  • Calciprotein particle (CPP): a true culprit of phosphorus woes?
    Kuro-o M
    Nefrologia : publicacion oficial de la Sociedad Espanola Nefrologia 34 1-4 2014
  • Klotho, phosphate and FGF-23 in ageing and disturbed mineral metabolism.
    Kuro-o M
    Nature reviews. Nephrology 9 650-660 Nov. 2013
  • Genetic deficiency of anti-aging gene klotho exacerbates early nephropathy in STZ-induced diabetes in male mice.
    Lin Y, Kuro-o M, Sun Z
    Endocrinology 154 3855-3863 Oct. 2013
  • Post-translational loss of renal TRPV5 calcium channel expression, Ca(2+) wasting, and bone loss in experimental colitis.
    Radhakrishnan VM, Ramalingam R, Larmonier CB, Thurston RD, Laubitz D, Midura-Kiela MT, McFadden RM, Kuro-O M, Kiela PR, Ghishan FK
    Gastroenterology 145 613-624 Sep. 2013
  • Amadori products promote cellular senescence activating insulin-like growth factor-1 receptor and down-regulating the antioxidant enzyme catalase.
    Del Nogal-Ávila M, Troyano-Suárez N, Román-García P, Cannata-Andía JB, Rodriguez-Puyol M, Rodriguez-Puyol D, Kuro-O M, Ruiz-Torres MP
    The international journal of biochemistry & cell biology 45 1255-1264 Jul. 2013
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Papers(paper)close
  • αKlotho and vascular calcification: an evolving paradigm.
    Hu MC, Kuro-O M, Moe OW
    Current opinion in nephrology and hypertension 23 331-339 Jul. 2014
  • 1,25(OH)2 vitamin D3-dependent inhibition of platelet Ca2+ signaling and thrombus formation in klotho-deficient mice.
    Borst O, Münzer P, Schmid E, Schmidt EM, Russo A, Walker B, Yang W, Leibrock C, Szteyn K, Schmidt S, Elvers M, Faggio C, Shumilina E, Kuro-o M, Gawaz M, Lang F
    FASEB journal : official publication of the Federation of American Societies for Experimental Biology 28 2108-2119 May 2014
  • Fibroblast growth factor 23 and uremic vascular calcification: is it time to escalate from biomarker status to pathogenic agent?
    Moe OW, Kuro-o M
    Kidney international 85 1022-1023 May 2014
  • Life extension factor klotho enhances cognition.
    Dubal DB, Yokoyama JS, Zhu L, Broestl L, Worden K, Wang D, Sturm VE, Kim D, Klein E, Yu GQ, Ho K, Eilertson KE, Yu L, Kuro-O M, De Jager PL, Coppola G, Small GW, Bennett DA, Kramer JH, Abraham CR, Miller BL, Mucke L
    Cell reports 7 1065-1076 May 2014
  • Loss of Memo, a novel FGFR regulator, results in reduced lifespan.
    Haenzi B, Bonny O, Masson R, Lienhard S, Dey JH, Kuro-o M, Hynes NE
    FASEB journal : official publication of the Federation of American Societies for Experimental Biology 28 327-336 Jan. 2014
  • Calciprotein particle (CPP): a true culprit of phosphorus woes?
    Kuro-o M
    Nefrologia : publicacion oficial de la Sociedad Espanola Nefrologia 34 1-4 2014
  • Klotho, phosphate and FGF-23 in ageing and disturbed mineral metabolism.
    Kuro-o M
    Nature reviews. Nephrology 9 650-660 Nov. 2013
  • Genetic deficiency of anti-aging gene klotho exacerbates early nephropathy in STZ-induced diabetes in male mice.
    Lin Y, Kuro-o M, Sun Z
    Endocrinology 154 3855-3863 Oct. 2013
  • Post-translational loss of renal TRPV5 calcium channel expression, Ca(2+) wasting, and bone loss in experimental colitis.
    Radhakrishnan VM, Ramalingam R, Larmonier CB, Thurston RD, Laubitz D, Midura-Kiela MT, McFadden RM, Kuro-O M, Kiela PR, Ghishan FK
    Gastroenterology 145 613-624 Sep. 2013
  • Amadori products promote cellular senescence activating insulin-like growth factor-1 receptor and down-regulating the antioxidant enzyme catalase.
    Del Nogal-Ávila M, Troyano-Suárez N, Román-García P, Cannata-Andía JB, Rodriguez-Puyol M, Rodriguez-Puyol D, Kuro-O M, Ruiz-Torres MP
    The international journal of biochemistry & cell biology 45 1255-1264 Jul. 2013
  • Altered regulation of cytosolic Ca²⁺ concentration in dendritic cells from klotho hypomorphic mice.
    Shumilina E, Nurbaeva MK, Yang W, Schmid E, Szteyn K, Russo A, Heise N, Leibrock C, Xuan NT, Faggio C, Kuro-o M, Lang F
    American journal of physiology. Cell physiology 305 C70-7 Jul. 2013
  • Renal and extrarenal actions of Klotho.
    Hu MC, Kuro-o M, Moe OW
    Seminars in nephrology 33 118-129 Mar. 2013
  • Spironolactone ameliorates PIT1-dependent vascular osteoinduction in klotho-hypomorphic mice.
    Voelkl J, Alesutan I, Leibrock CB, Quintanilla-Martinez L, Kuhn V, Feger M, Mia S, Ahmed MS, Rosenblatt KP, Kuro-O M, Lang F
    The Journal of clinical investigation 123 812-822 Feb. 2013
  • The secreted Klotho protein restores phosphate retention and suppresses accelerated aging in Klotho mutant mice.
    Chen TH, Kuro-O M, Chen CH, Sue YM, Chen YC, Wu HH, Cheng CY
    European journal of pharmacology 698 67-73 Jan. 2013
  • The antiaging protein Klotho enhances oligodendrocyte maturation and myelination of the CNS.
    Chen CD, Sloane JA, Li H, Aytan N, Giannaris EL, Zeldich E, Hinman JD, Dedeoglu A, Rosene DL, Bansal R, Luebke JI, Kuro-o M, Abraham CR
    The Journal of neuroscience : the official journal of the Society for Neuroscience 33 1927-1939 Jan. 2013
  • Fibroblast growth factor 23 and Klotho: physiology and pathophysiology of an endocrine network of mineral metabolism.
    Hu MC, Shiizaki K, Kuro-o M, Moe OW
    Annual review of physiology 75 503-533 2013
  • Klotho and chronic kidney disease.
    Hu MC, Kuro-o M, Moe OW
    Contributions to nephrology 180 47-63 2013
  • Pin1 null mice exhibit low bone mass and attenuation of BMP signaling.
    Shen ZJ, Hu J, Ali A, Pastor J, Shiizaki K, Blank RD, Kuro-o M, Malter JS
    PloS one 8 e63565 2013
  • Vitamin D receptor agonists increase klotho and osteopontin while decreasing aortic calcification in mice with chronic kidney disease fed a high phosphate diet.
    Lau WL, Leaf EM, Hu MC, Takeno MM, Kuro-o M, Moe OW, Giachelli CM
    Kidney international 82 1261-1270 Dec. 2012
  • Characteristics of urinary and serum soluble Klotho protein in patients with different degrees of chronic kidney disease.
    Akimoto T, Yoshizawa H, Watanabe Y, Numata A, Yamazaki T, Takeshima E, Iwazu K, Komada T, Otani N, Morishita Y, Ito C, Shiizaki K, Ando Y, Muto S, Kuro-o M, Kusano E
    BMC nephrology 13 155 Nov. 2012
  • Promoter methylation confers kidney-specific expression of the Klotho gene.
    Azuma M, Koyama D, Kikuchi J, Yoshizawa H, Thasinas D, Shiizaki K, Kuro-o M, Furukawa Y, Kusano E
    FASEB journal : official publication of the Federation of American Societies for Experimental Biology 26 4264-4274 Oct. 2012
  • [A potential link between phosphate and aging].
    Shiizaki K, Kuro-o M
    Clinical calcium 22 1493-1498 Oct. 2012
  • Conversion of a paracrine fibroblast growth factor into an endocrine fibroblast growth factor.
    Goetz R, Ohnishi M, Kir S, Kurosu H, Wang L, Pastor J, Ma J, Gai W, Kuro-o M, Razzaque MS, Mohammadi M
    The Journal of biological chemistry 287 29134-29146 Aug. 2012
  • Nuclear localization of Klotho in brain: an anti-aging protein.
    German DC, Khobahy I, Pastor J, Kuro-O M, Liu X
    Neurobiology of aging 33 1483.e25-30 Jul. 2012
  • Klotho in health and disease.
    Kuro-o M
    Current opinion in nephrology and hypertension 21 362-368 Jul. 2012
  • The emerging role of Klotho in clinical nephrology.
    Hu MC, Kuro-o M, Moe OW
    Nephrology, dialysis, transplantation : official publication of the European Dialysis and Transplant Association - European Renal Association 27 2650-2657 Jul. 2012
  • Klotho gene delivery suppresses Nox2 expression and attenuates oxidative stress in rat aortic smooth muscle cells via the cAMP-PKA pathway.
    Wang Y, Kuro-o M, Sun Z
    Aging cell 11 410-417 Jun. 2012
  • The relationship between the soluble Klotho protein and the residual renal function among peritoneal dialysis patients.
    Akimoto T, Shiizaki K, Sugase T, Watanabe Y, Yoshizawa H, Otani N, Numata A, Takeshima E, Yamazaki T, Miki T, Ito C, Pastor JV, Iwazu Y, Saito O, Muto S, Kuro-o M, Kusano E
    Clinical and experimental nephrology 16 442-447 Jun. 2012
  • Reduced Klotho expression level in kidney aggravates renal interstitial fibrosis.
    Sugiura H, Yoshida T, Shiohira S, Kohei J, Mitobe M, Kurosu H, Kuro-o M, Nitta K, Tsuchiya K
    American journal of physiology. Renal physiology 302 F1252-64 May 2012
  • Klotho coreceptors inhibit signaling by paracrine fibroblast growth factor 8 subfamily ligands.
    Goetz R, Ohnishi M, Ding X, Kurosu H, Wang L, Akiyoshi J, Ma J, Gai W, Sidis Y, Pitteloud N, Kuro-O M, Razzaque MS, Mohammadi M
    Molecular and cellular biology 32 1944-1954 May 2012
  • Klotho and βKlotho.
    Kuro-o M
    Advances in experimental medicine and biology 728 25-40 2012
  • Secreted klotho and chronic kidney disease.
    Hu MC, Kuro-o M, Moe OW
    Advances in experimental medicine and biology 728 126-157 2012
  • Protective roles of DMP1 in high phosphate homeostasis.
    Rangiani A, Cao Z, Sun Y, Lu Y, Gao T, Yuan B, Rodgers A, Qin C, Kuro-O M, Feng JQ
    PloS one 7 e42329 2012
  • Cardioprotection by Klotho through downregulation of TRPC6 channels in the mouse heart.
    Xie J, Cha SK, An SW, Kuro-O M, Birnbaumer L, Huang CL
    Nature communications 3 1238 2012
  • Alteration in N-glycomics during mouse aging: a role for FUT8.
    Vanhooren V, Dewaele S, Kuro-O M, Taniguchi N, Dollé L, van Grunsven LA, Makrantonaki E, Zouboulis CC, Chen CC, Libert C
    Aging cell 10 1056-1066 Dec. 2011
  • Short hairpin RNA screen indicates that Klotho beta/FGF19 protein overcomes stasis in human colonic epithelial cells.
    Kim J, Eskiocak U, Stadler G, Lou Z, Kuro-o M, Shay JW, Wright WE
    The Journal of biological chemistry 286 43294-43300 Dec. 2011
  • FGF23 induces left ventricular hypertrophy.
    Faul C, Amaral AP, Oskouei B, Hu MC, Sloan A, Isakova T, Gutiérrez OM, Aguillon-Prada R, Lincoln J, Hare JM, Mundel P, Morales A, Scialla J, Fischer M, Soliman EZ, Chen J, Go AS, Rosas SE, Nessel L, Townsend RR, Feldman HI, St John Sutton M, Ojo A, Gadegbeku C, Di Marco GS, Reuter S, Kentrup D, Tiemann K, Brand M, Hill JA, Moe OW, Kuro-O M, Kusek JW, Keane MG, Wolf M
    The Journal of clinical investigation 121 4393-4408 Nov. 2011
  • Improved protein arrays for quantitative systems analysis of the dynamics of signaling pathway interactions.
    Wang X, Dong Y, Jiwani AJ, Zou Y, Pastor J, Kuro-O M, Habib AA, Ruan M, Boothman DA, Yang CR
    Proteome science 9 53 Sep. 2011
  • Pregnane X receptor activation induces FGF19-dependent tumor aggressiveness in humans and mice.
    Wang H, Venkatesh M, Li H, Goetz R, Mukherjee S, Biswas A, Zhu L, Kaubisch A, Wang L, Pullman J, Whitney K, Kuro-o M, Roig AI, Shay JW, Mohammadi M, Mani S
    The Journal of clinical investigation 121 3220-3232 Aug. 2011
  • Role of Klotho in aging, phosphate metabolism, and CKD.
    John GB, Cheng CY, Kuro-o M
    American journal of kidney diseases : the official journal of the National Kidney Foundation 58 127-134 Jul. 2011
  • Regulation of the Na+/K+ ATPase by Klotho.
    Sopjani M, Alesutan I, Dërmaku-Sopjani M, Gu S, Zelenak C, Munoz C, Velic A, Föller M, Rosenblatt KP, Kuro-o M, Lang F
    FEBS letters 585 1759-1764 Jun. 2011
  • Klotho and the aging process.
    Kuro-o M
    The Korean journal of internal medicine 26 113-122 Jun. 2011
  • Phosphate and Klotho.
    Kuro-O M
    Kidney international. Supplement S20-3 Apr. 2011
  • Angiotensin II blockade upregulates the expression of Klotho, the anti-ageing gene, in an experimental model of chronic cyclosporine nephropathy.
    Yoon HE, Ghee JY, Piao S, Song JH, Han DH, Kim S, Ohashi N, Kobori H, Kuro-o M, Yang CW
    Nephrology, dialysis, transplantation : official publication of the European Dialysis and Transplant Association - European Renal Association 26 800-813 Mar. 2011
  • Klotho inhibits transforming growth factor-beta1 (TGF-beta1) signaling and suppresses renal fibrosis and cancer metastasis in mice.
    Doi S, Zou Y, Togao O, Pastor JV, John GB, Wang L, Shiizaki K, Gotschall R, Schiavi S, Yorioka N, Takahashi M, Boothman DA, Kuro-o M
    The Journal of biological chemistry 286 8655-8665 Mar. 2011
  • Molecular regulation of phosphate metabolism by fibroblast growth factor-23-klotho system.
    Cheng CY, Kuro-o M, Razzaque MS
    Advances in chronic kidney disease 18 91-97 Mar. 2011
  • Klotho deficiency causes vascular calcification in chronic kidney disease.
    Hu MC, Shi M, Zhang J, Quiñones H, Griffith C, Kuro-o M, Moe OW
    Journal of the American Society of Nephrology : JASN 22 124-136 Jan. 2011
  • Klotho deficiency is an early biomarker of renal ischemia-reperfusion injury and its replacement is protective.
    Hu MC, Shi M, Zhang J, Quiñones H, Kuro-o M, Moe OW
    Kidney international 78 1240-1251 Dec. 2010
  • Hyperaldosteronism in Klotho-deficient mice.
    Fischer SS, Kempe DS, Leibrock CB, Rexhepaj R, Siraskar B, Boini KM, Ackermann TF, Föller M, Hocher B, Rosenblatt KP, Kuro-O M, Lang F
    American journal of physiology. Renal physiology 299 F1171-7 Nov. 2010
  • Bone marrow-derived cells contribute to vascular inflammation but do not differentiate into smooth muscle cell lineages.
    Iwata H, Manabe I, Fujiu K, Yamamoto T, Takeda N, Eguchi K, Furuya A, Kuro-o M, Sata M, Nagai R
    Circulation 122 2048-2057 Nov. 2010
  • Klotho and kidney disease.
    Hu MC, Kuro-o M, Moe OW
    Journal of nephrology 23 Suppl 16 S136-44 Nov. 2010
  • Research resource: Comprehensive expression atlas of the fibroblast growth factor system in adult mouse.
    Fon Tacer K, Bookout AL, Ding X, Kurosu H, John GB, Wang L, Goetz R, Mohammadi M, Kuro-o M, Mangelsdorf DJ, Kliewer SA
    Molecular endocrinology (Baltimore, Md.) 24 2050-2064 Oct. 2010
  • Klotho: a novel phosphaturic substance acting as an autocrine enzyme in the renal proximal tubule.
    Hu MC, Shi M, Zhang J, Pastor J, Nakatani T, Lanske B, Razzaque MS, Rosenblatt KP, Baum MG, Kuro-o M, Moe OW
    FASEB journal : official publication of the Federation of American Societies for Experimental Biology 24 3438-3450 Sep. 2010
  • The ASK1-Signalosome regulates p38 MAPK activity in response to levels of endogenous oxidative stress in the Klotho mouse models of aging.
    Hsieh CC, Kuro-o M, Rosenblatt KP, Brobey R, Papaconstantinou J
    Aging 2 597-611 Sep. 2010
  • Loss of Kitlow progenitors, reduced stem cell factor and high oxidative stress underlie gastric dysfunction in progeric mice.
    Izbeki F, Asuzu DT, Lorincz A, Bardsley MR, Popko LN, Choi KM, Young DL, Hayashi Y, Linden DR, Kuro-o M, Farrugia G, Ordog T
    The Journal of physiology 588 3101-3117 Aug. 2010
  • Ultra-short echo time (UTE) MR imaging of the lung: comparison between normal and emphysematous lungs in mutant mice.
    Takahashi M, Togao O, Obara M, van Cauteren M, Ohno Y, Doi S, Kuro-o M, Malloy C, Hsia CC, Dimitrov I
    Journal of magnetic resonance imaging : JMRI 32 326-333 Aug. 2010
  • Assessment of renal fibrosis with diffusion-weighted MR imaging: study with murine model of unilateral ureteral obstruction.
    Togao O, Doi S, Kuro-o M, Masaki T, Yorioka N, Takahashi M
    Radiology 255 772-780 Jun. 2010
  • Overview of the FGF23-Klotho axis.
    Kuro-o M
    Pediatric nephrology (Berlin, Germany) 25 583-590 Apr. 2010
  • A potential link between phosphate and aging--lessons from Klotho-deficient mice.
    Kuro-o M
    Mechanisms of ageing and development 131 270-275 Apr. 2010
  • Klotho.
    Kuro-o M
    Pflugers Archiv : European journal of physiology 459 333-343 Jan. 2010
  • Isolated C-terminal tail of FGF23 alleviates hypophosphatemia by inhibiting FGF23-FGFR-Klotho complex formation.
    Goetz R, Nakada Y, Hu MC, Kurosu H, Wang L, Nakatani T, Shi M, Eliseenkova AV, Razzaque MS, Moe OW, Kuro-o M, Mohammadi M
    Proceedings of the National Academy of Sciences of the United States of America 107 407-412 Jan. 2010
  • Klotho variants and chronic hemodialysis mortality.
    Friedman DJ, Afkarian M, Tamez H, Bhan I, Isakova T, Wolf M, Ankers E, Ye J, Tonelli M, Zoccali C, Kuro-o M, Moe O, Karumanchi SA, Thadhani R
    Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research 24 1847-1855 Nov. 2009
  • Klotho and aging.
    Kuro-o M
    Biochimica et biophysica acta 1790 1049-1058 Oct. 2009
  • Klotho is a substrate for alpha-, beta- and gamma-secretase.
    Bloch L, Sineshchekova O, Reichenbach D, Reiss K, Saftig P, Kuro-o M, Kaether C
    FEBS letters 583 3221-3224 Oct. 2009
  • Accelerated suicidal erythrocyte death in Klotho-deficient mice.
    Kempe DS, Ackermann TF, Fischer SS, Koka S, Boini KM, Mahmud H, Föller M, Rosenblatt KP, Kuro-O M, Lang F
    Pflugers Archiv : European journal of physiology 458 503-512 Jul. 2009
  • Regulation of renal outer medullary potassium channel and renal K(+) excretion by Klotho.
    Cha SK, Hu MC, Kurosu H, Kuro-o M, Moe O, Huang CL
    Molecular pharmacology 76 38-46 Jul. 2009
  • Klotho in chronic kidney disease--what's new?
    Kuro-o M
    Nephrology, dialysis, transplantation : official publication of the European Dialysis and Transplant Association - European Renal Association 24 1705-1708 Jun. 2009
  • The Klotho gene family as a regulator of endocrine fibroblast growth factors.
    Kurosu H, Kuro-O M
    Molecular and cellular endocrinology 299 72-78 Feb. 2009
  • Endocrine fibroblast growth factors as regulators of metabolic homeostasis.
    Kurosu H, Kuro-O M
    BioFactors (Oxford, England) 35 52-60 Jan. 2009
  • Endocrine FGFs and Klothos: emerging concepts.
    Kuro-o M
    Trends in endocrinology and metabolism: TEM 19 239-245 Sep. 2008
  • FGF-23-Klotho signaling stimulates proliferation and prevents vitamin D-induced apoptosis.
    Medici D, Razzaque MS, Deluca S, Rector TL, Hou B, Kang K, Goetz R, Mohammadi M, Kuro-O M, Olsen BR, Lanske B
    The Journal of cell biology 182 459-465 Aug. 2008
  • Removal of sialic acid involving Klotho causes cell-surface retention of TRPV5 channel via binding to galectin-1.
    Cha SK, Ortega B, Kurosu H, Rosenblatt KP, Kuro-O M, Huang CL
    Proceedings of the National Academy of Sciences of the United States of America 105 9805-9810 Jul. 2008
  • The Klotho gene family and the endocrine fibroblast growth factors.
    Kurosu H, Kuro-o M
    Current opinion in nephrology and hypertension 17 368-372 Jul. 2008
  • Klotho as a regulator of oxidative stress and senescence.
    Kuro-o M
    Biological chemistry 389 233-241 Mar. 2008
  • Aromatase deficiency causes altered expression of molecules critical for calcium reabsorption in the kidneys of female mice *.
    Oz OK, Hajibeigi A, Howard K, Cummins CL, van Abel M, Bindels RJ, Word RA, Kuro-o M, Pak CY, Zerwekh JE
    Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research 22 1893-1902 Dec. 2007
  • The parathyroid is a target organ for FGF23 in rats.
    Ben-Dov IZ, Galitzer H, Lavi-Moshayoff V, Goetz R, Kuro-o M, Mohammadi M, Sirkis R, Naveh-Many T, Silver J
    The Journal of clinical investigation 117 4003-4008 Dec. 2007
  • FoxO transcription factors activate Akt and attenuate insulin signaling in heart by inhibiting protein phosphatases.
    Ni YG, Wang N, Cao DJ, Sachan N, Morris DJ, Gerard RD, Kuro-O M, Rothermel BA, Hill JA
    Proceedings of the National Academy of Sciences of the United States of America 104 20517-20522 Dec. 2007
  • Tissue-specific expression of betaKlotho and fibroblast growth factor (FGF) receptor isoforms determines metabolic activity of FGF19 and FGF21.
    Kurosu H, Choi M, Ogawa Y, Dickson AS, Goetz R, Eliseenkova AV, Mohammadi M, Rosenblatt KP, Kliewer SA, Kuro-o M
    The Journal of biological chemistry 282 26687-26695 Sep. 2007
  • Molecular insights into the klotho-dependent, endocrine mode of action of fibroblast growth factor 19 subfamily members.
    Goetz R, Beenken A, Ibrahimi OA, Kalinina J, Olsen SK, Eliseenkova AV, Xu C, Neubert TA, Zhang F, Linhardt RJ, Yu X, White KE, Inagaki T, Kliewer SA, Yamamoto M, Kurosu H, Ogawa Y, Kuro-o M, Lanske B, Razzaque MS, Mohammadi M
    Molecular and cellular biology 27 3417-3428 May 2007
  • BetaKlotho is required for metabolic activity of fibroblast growth factor 21.
    Ogawa Y, Kurosu H, Yamamoto M, Nandi A, Rosenblatt KP, Goetz R, Eliseenkova AV, Mohammadi M, Kuro-o M
    Proceedings of the National Academy of Sciences of the United States of America 104 7432-7437 May 2007
  • Sustained thymopoiesis and improvement in functional immunity induced by exogenous KGF administration in murine models of aging.
    Min D, Panoskaltsis-Mortari A, Kuro-O M, Holländer GA, Blazar BR, Weinberg KI
    Blood 109 2529-2537 Mar. 2007
  • [Recent progress in Klotho research].
    Kuro-o M
    Nihon Ronen Igakkai zasshi. Japanese journal of geriatrics 43 674-681 Nov. 2006
  • Klotho as a regulator of fibroblast growth factor signaling and phosphate/calcium metabolism.
    Kuro-o M
    Current opinion in nephrology and hypertension 15 437-441 Jul. 2006
  • Regulation of fibroblast growth factor-23 signaling by klotho.
    Kurosu H, Ogawa Y, Miyoshi M, Yamamoto M, Nandi A, Rosenblatt KP, Baum MG, Schiavi S, Hu MC, Moe OW, Kuro-o M
    The Journal of biological chemistry 281 6120-6123 Mar. 2006
  • Regulation of multiple ageing-like phenotypes by inducible klotho gene expression in klotho mutant mice.
    Masuda H, Chikuda H, Suga T, Kawaguchi H, Kuro-o M
    Mechanisms of ageing and development 126 1274-1283 Dec. 2005
  • Regulation of oxidative stress by the anti-aging hormone klotho.
    Yamamoto M, Clark JD, Pastor JV, Gurnani P, Nandi A, Kurosu H, Miyoshi M, Ogawa Y, Castrillon DH, Rosenblatt KP, Kuro-o M
    The Journal of biological chemistry 280 38029-38034 Nov. 2005
  • Suppression of aging in mice by the hormone Klotho.
    Kurosu H, Yamamoto M, Clark JD, Pastor JV, Nandi A, Gurnani P, McGuinness OP, Chikuda H, Yamaguchi M, Kawaguchi H, Shimomura I, Takayama Y, Herz J, Kahn CR, Rosenblatt KP, Kuro-o M
    Science (New York, N.Y.) 309 1829-1833 Sep. 2005
  • Klotho insufficiency causes decrease of ribosomal RNA gene transcription activity, cytoplasmic RNA and rough ER in the spinal anterior horn cells.
    Anamizu Y, Kawaguchi H, Seichi A, Yamaguchi S, Kawakami E, Kanda N, Matsubara S, Kuro-o M, Nabeshima Y, Nakamura K, Oyanagi K
    Acta neuropathologica 109 457-466 May 2005
  • Na+/Ca2+ exchanger-deficient mice have disorganized myofibrils and swollen mitochondria in cardiomyocytes.
    Wakimoto K, Fujimura H, Iwamoto T, Oka T, Kobayashi K, Kita S, Kudoh S, Kuro-o M, Nabeshima Yi, Shigekawa M, Imai Y, Komuro I
    Comparative biochemistry and physiology. Part B, Biochemistry & molecular biology 135 9-15 May 2003
  • Klotho gene polymorphisms associated with bone density of aged postmenopausal women.
    Kawano K, Ogata N, Chiano M, Molloy H, Kleyn P, Spector TD, Uchida M, Hosoi T, Suzuki T, Orimo H, Inoue S, Nabeshima Y, Nakamura K, Kuro-o M, Kawaguchi H
    Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research 17 1744-1751 Oct. 2002
  • Production of nitric oxide, but not prostacyclin, is reduced in klotho mice.
    Nakamura T, Saito Y, Ohyama Y, Masuda H, Sumino H, Kuro-o M, Nabeshima Y, Nagai R, Kurabayashi M
    Japanese journal of pharmacology 89 149-156 Jun. 2002


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