Researchers Database

sasaguri kenichi

    DentistryandOralSurgery Associate Professor
Last Updated :2021/11/23

Researcher Information

J-Global ID

Research Interests

  • ガレクチン-1   ストレス   マウス   マクロファージ   拘束ストレス   Galectin-1   ヒト骨芽細胞   なし   歯の移動   CADIAX ver.2.0   遺伝子   PCR   TRAP染色   Morris水迷路   空間認知記憶能   (5)cafal   習慣性開口運動   上顎前歯   顎関節雑音   (1)マウス   Cbfa1   側方偏位量   (4)TRAP染色   saliva   顎機能正常者群   顎機能不正常者群   (2)歯の移動   P.gingivalis   海馬   

Research Areas

  • Life sciences / Developmental dentistry
  • Life sciences / Conservative dentistry and endodontics
  • Life sciences / Prosthodontics
  • Life sciences / Prosthodontics

Academic & Professional Experience

  • 2013 - 2014  Kanagawa Dental CollegeSchool of Dentistry講師

MISC

  • OKADA Suzuhito, SASAGURI Kenichi, SATO Sadao  日本顎咬合学会誌 : 咬み合わせの科学 = Journal of the Academy of Gnathology and Occlusion  29-  (1)  27  -34  2009/04  [Not refereed][Not invited]
  • Okada Suzuhito, Sasaguri Kenichi, Sato Sadao  THE JOURNAL OF THE ACADEMY OF CLINICAL DENTISTRY  29-  (1)  27  -34  2009  [Not refereed][Not invited]
     
    The perception of stress by an individual activates the CNS with two major consequences: the neuroendocrine system responds via the HPA axis and the autonomic nervous system responds, causing sympathetic nerve termini to locally release catecholamines. Each of these processes have a potential cost to the body when allostasis is either called upon too often or is inefficiently managed,and that cost is referred to as "allostatic load". We investigated the effects of biting on restraints stress-induced high blood pressure and core temperature as an allostatic load accumulation, and chemical mediators in the serum for further define. Biting of a wooden stick during restraint resulted in a significant reduction of blood pressure at 30, 45, 60 and 75 min, and significant inhibition in core temperature at 30, 60, 120, and 180 min compare with restraint-only rats and these differences are visible in the comparison of infrared thermal images of the restraint-only and restraint with biting rats after 60 min. Biochemical analysis revealed that plasma interleukin(IL)-1β, IL-6, and leptin were significantly suppressed by biting and thyroid stimulating hormone was significantly increased by biting. These results suggest a possible anti-stress effect of biting and an important role of para-functional masticatory activity in coping with stressful events.
  • KAWAGOE Toshimi, SARUTA Juri, MIYAKE Shinjiro, SASAGURI Kenichi, AKIMOTO Susumu, SATO Sadao  Journal of dental health  58-  (5)  542  -547  2008/10  [Not refereed][Not invited]
     
    In order to test whether the occlusal contact pattern is a factor that contributes to the development of non-carious cervical lesions (NCCLs), 15 dentists clinically investigated their prevalence in the general population in two different ways to classify the occlusal scheme (one based on the tooth-contact pattern during wakefulness and the other on that during sleep). We established the occlusal contact pattern of 240 subjects during sleep bruxism with BruxChecker. We checked the 6,564 teeth of the total subjects and examined the NCCL prevalence regarding each tooth. The overall prevalence of NCCL was 11.4%. The prevalence increased with age: 7.1% for people in their 20s to 15.8% for people in their 50s. Based on the standard 5-category occlusal contact patterns established by BruxChecker, there was a significant difference between the proportion of NCCLs identified in bilateral group function grinding subjects (12.8%) and that in bilateral canine dominance grinding subjects (3.6%). Using the new 3-category system (incisor-canine grinding (IC) subjects, incisor-canine-premolar grinding (ICP) subjects, and incisor-canine-premolar-molar grinding (ICPM) subjects), there was a significant difference between the proportion of NCCLs identified in bilateral ICP subjects (13.5%) and bilateral ICPM subjects (13.6%) than in bilateral IC subjects (3.6%). It was proportional to the laterotrusive-side occlusal contact area. We conclude that the prevalence of cervical lesions is significantly related to occlusion, and that the risk of non-carious cervical lesions is a function of the laterotrusive-side occlusal contact area.
  • SATO Sadao, SASAGURI Kenichi, HORI Norio, YUYAMA Noriyuki, TSUKINOKI Keiichi, LEE Masaichi, ONOZUKA Minoru  日本歯科医学会誌 = Journal of the Japanese Association for Dental Science : JJDS  (24)  82  -86  2005/03  [Not refereed][Not invited]
  • Sasaguri Kenichi, Sato Sadao, Kobayashi Masaru, Kubota Eiro, Jinbu Yoshinori, Kusama Mikio  Jichi Medical School journal  27-  127  -133  2004/12  [Not refereed][Not invited]
     
    The patient was an 11-year, 11-month-old male who had the chief complaint of progenia and anterior open bite. We diagnosed his case as skeletal mandibular protrusion because of the excess growth of the mandible. We had applied both a multi bracket appliance (MBA) in order to control the inclination of the incisors and a protractor to promote the growth of the maxilla and to suppress the growth of the mandible for approximately 3 years since he was 12 years, 1 month old. However, the ideal over jet and over bite hadn't been established ; we decided to remove all the appliances at once and improve the occlusion surgically after the whole body growth had finished. When he was 17 years, 1 month old, the growth was completed ; we reexamined his case, after which we started to apply an MBA as a preoperative orthodontic treatment. After the preoperative orthodontic treatment had finished examined with model surgery by using laser lithography methods, the Le-Fort I procedure was performed to elevate the posterior part of the occlusal plane and moveif forward. Moreover, sagittal splitting ramus osteotomy was carried out on both sides and set back for repositioning of the maxillary and mandibular bone fragments. We established the constitution of the ideal occlusion by postoperative orthodontic treatment ; thus, we would report this case with some reference-consideration.
  • 猿田 樹理, 槻木 恵一, 石井 秀典, 笹栗 健一, 渡辺 是久, 佐藤 貞雄  Journal of oral biosciences  46-  (5)  2004/09  [Not refereed][Not invited]
  • 三宅 真次郎, 高橋 俊介, 笹栗 健一, 李 昌一, 佐藤 貞雄  Journal of oral biosciences  46-  (5)  2004/09  [Not refereed][Not invited]
  • HORI N, KIMOTO K, AOKI H, YUYAMA N, SASAGURI K, SATO S, TOYODA M  日本補綴歯科學會雜誌 = The journal of the Japan Prosthodontic Society  47-  2003/10  [Not refereed][Not invited]
  • ISHIZAKI Rika, SASAGURI Kenichi, HORIGUCHI Miwa, CHUNG Woon-Nahm, SATO Sadao  日本顎咬合学会誌 : 咬み合わせの科学 = Journal of the Academy of Gnathology and Occlusion  23-  (1)  12  -21  2003/01  [Not refereed][Not invited]
  • Ishizaki Rika, Sasaguri Kenichi, Horiguchi Miwa, Chung Woon-Nahm, Sato Sadao  The Journal of Japan Gnathology  23-  (1)  12  -21  2003  [Not refereed][Not invited]
     
    The patient was 18 years old female with chief complaint of intermittent closed lock, sound and pain on opening movement on left temporomandibular joint (TMJ), especially rising. Though her maximum opening range of jaw opening was limited less than 27mm, she was able to normal opening when she was made eccentric jaw opening movement. In the MRI view in which both side TMJ were anterior disk displacement with reduction. Based on axiograph view, we considered that click-ing during mouth closing occurred in the mandibular position in which the displaced disc returned to the normal position on the chondyle, as we called therapeutic reference position (TRP), and per-formed therapy of using functional appliance. After the elimination of the clinical symptom is confirmed, as clicking, sound and pain during jaw movement, the occlusal reconstruction was per-formed by using the three dimensional control of tooth which multi-bracket method for TRP jointly with the functional appliance. The reconstructed occlusion was obtained with disappearance of all clinical symptoms passed after 2 years of post retention.<BR>Therefore, it is possible that the therapy of occlusal reconstitution using the technique of orthodontics was an effective treatment for the anterior disc displacement with reduction case.
  • 草深 公秀, 笹栗 健一, 佐藤 貞夫, 山口 朗  歯科基礎医学会雑誌  44-  (5)  2002/09  [Not refereed][Not invited]
  • 半田 慶介, 角田 晃, 齋藤 正寛, 寺中 敏夫, 山内 雅人, 笹栗 健一, 佐藤 貞雄  歯科基礎医学会雑誌  42-  (5)  2000/08  [Not refereed][Not invited]
  • Sasaguri Kenichi, Tanaka Tamami, Ishizaki Rika, Kim Riho, Sato Sadao  The Journal of Japan Gnathology  21-  (1)  69  -75  2000  [Not refereed][Not invited]
     
    Splint therapy is a major type of conservative therapy for patient with temporomandibular joint disorders. In particularly, application of splint is useful therapy for anterior disc displacement with reduction case because mandibular position to be obtained in treatment goal as disc recapture position. However, the relationship between the disc and condyle are normal only when the splint is placed to maintain the mandibular position guided by the splint. Therefore, it is important to stabilize the mandibular postion guided by the splint as much as possible by using prosthetic or orthodontic technique for reconstructing normal occlusion. We report a case in which a patient was given orthodontic treatment 17 years ago and seemed to obtain functional occlusion. However, in the passed ten year after posttreatment, the patient had bilateral internal derangement of temporomandibular joint of disc displacement with reduction. Based on axiograph and MRI findings, we considered that clicking during mouth closing occurred in the mandibular position in which the displaced disc returned to the normal position on the condyle, and performed splint therapy, by which disappearance of clicking and subjective symptoms were obtained. We stabilized occlusion by the splint and tooth movement, setting the mandibular position as the position to be obtained in the treatment goal, and reconstructed occlusion was obtained with disappearance of all clinical symptoms. We retained the finally obtained mandibular position using a functional appliance (FA), and retention was maintained three years and nine months after post treatment.
  • 笹栗 健一, 山内 雅人, 長谷川 英二, 佐藤 貞雄, 槻木 恵一, 渡辺 是久  歯科基礎医学会雑誌  41-  (5)  1999/08  [Not refereed][Not invited]
  • 山藤 雅良, 笹栗 健一, 国分 康有, 久保田 隆朗, 高垣 裕子, 佐藤 貞雄  日本骨代謝学会雑誌 = Japanese journal of bone metabolism  17-  (2)  1999/06  [Not refereed][Not invited]
  • 宮内 章光, 笹栗 健一, 能登谷 浩平, 久保田 隆朗, 高木 康行, 武富 滋久, 藤井 芳夫, 大西 毅尚, GUO Xiao-Li, HRUSKA Keith A, 佐藤 貞雄, 斉藤 滋, 藤田 拓男, 高垣 裕子  日本骨代謝学会雑誌 = Japanese journal of bone metabolism  15-  (2)  1997/06  [Not refereed][Not invited]
  • TAKEUCHI Makoto, SASAGURI Kenichi, SUGISHITA Tamami, SATO Sadao, SUZUKI Yoshii  TMJ : journal of Japanese Society for Temporomandibular Joint : 日本顎関節学会雑誌  7-  (1)  63  -74  1995/05  [Not refereed][Not invited]
  • TAKEUCHI Makoto, SASAGURI Kenichi, SUGISHITA Tamami, SATO Sadao, SUZUKI Yoshii  Gakukansetsu Kenkyukaishi  7-  (1)  63  -74  1995  [Not refereed][Not invited]
     
    Mandibular opening movement is composed of a combination of condylar rotation and translation. The purpose of this investigation was to study the relationship between condylar rotation and translation during opening movements in order to clarify whether these two moving components are available for diagnosis of temporomandibular (TM) joint disorder.Twenty seven subjects without signs or symptoms of TM joint disorders (normal group) and 20 subjects with at least unilateral clicking joint (TMD group) were examind regarding with the amount of condylar rotation and translation and the relationship between these two moving components utilizing computerized axiographs. Anterior complete disk displacement with reduction was confirmed by magnetic resonance imaging. The amount of condylar translation of the TMD group was longer than that of the normal group in the opening movement, while the amount of the condylar rotation was not significantly different in these two groups. It was suggested that the excessive translation in the TMD group resulted from looseness of the capsule and lateral ligament. Furthermore, results indicated a highly linear relationship between condylar rotation and translation except for the terminal end of the opening movement in the normal group. The final stage of the opening movement in the normal group mostly consisted of condylar rotation. On the other hand, the opening movement in the TMD group started with rotation movement predominance, and finished by the same ratio of rotation and translation movements.It was concluded that the examination of the relationship between condylar rotation and translation can be useful for a diagnosis of TM joint dysfunction including loose ligament.
  • SASAGURI Kenichi, TAKEUCHI Makoto, SUGISHITA Tamami, SATO Sadao, SUZUKI Yoshii  Gakukansetsu Kenkyukaishi  6-  (2)  315  -324  1994  [Not refereed][Not invited]
     
    The purpose of this study was to clarify the relationship between the coincidence of the right and left condylar translation and the length of horizontal condylar pathways in groups with temporomandibular (TM) joint dysfunction (TMD group) and TM joint normal function (normal group).The length of horizontal condylar pathways of the TMD group was longer than that of the normal group in habitual opening movement. However, the comparison of the length of the right and left condylar translation pathways was not significantly different. The coincidence of the right and left condylar translation movement of the TMD group in the habitual opening movement had more variance than that of the normal group. In order to determine whether the length of horizontal condylar pathways relates to the coincidence of the right and left condylar translation, a linear correlation analysis was performed. The length of horizontal condylar pathways and variance of the right and left condylar translation in TMD group correlated significantly (p<0.01).It was suggested that the TMD group had a variance in the right and left condylar translation movement and longer horizontal condylar pathways during habitual opening movement due to the loosening of TM joint structures.
  • Onozaki Jun, Kubota Takao, Sasaguri Kenichi, Sato Sadao, Suzuki Yoshii  Journal of Oral Biosciences  34-  (6)  630  -641  1992  [Not refereed][Not invited]
     
    Transforming growth factor-β(TGF-β) is a multifunctional polypeptide th at influences proliferation and differentiation in various types of cell. It has been recognized that platelets and bone are rich sources of TGF-β. However, using molecular hybridization, it has been demonstrated that periodontal cells also expressed a high level of TGF-β mRNA, relative to bone cells. This studyh as been extended on human periodontal ligament fibroblast (HPLF) by investig ating the effect of TGF-β on the synthesis of proteoglycans, which are believed to be an important factor in bone remodeling. Cells were incubated to be labeled with 35S-sulfate. The expression of proteoglycan mRNA was also observed by northern blots. Utilizing the characterized data of HPLF cells (Sommerman, M. J. et al., J. Dent. Res., 67: 66, 1988), the cells which had high alkaline phosphatase (ALP) activity were chosen. On HPLF cell-line produced predominantly the proteogl ycan II (Decorin; PG II). No stimulating effects of PG II synthesis were observed by TGF -β. However, TGF-β stimulated the expression of mRNA of proteoglycan I (Biglycan; PG I) and the synthesis of 35S-sulfate labeled PG I. According to the time course study, mRNA of PG I was increased after 12 h exposure to TGF-β. These results suggest that the PG I synthesis might be enhanced by indirect TGF-β effects and PG I synthesis is believed to be important for periodontal remodeling.
  • Sasaguri Kenichi  Journal of Oral Biosciences  33-  (3)  261  -274  1991  [Not refereed][Not invited]
     
    It has been reported that bone type alkaline phosphatase (ALP) has a higher activity in human periodontal ligament fibroblasts (HPLF) than that of other soft connective tissue cells, such as gingiva and skin 6broblasts.Since the ALP activity of HPLF is markedly stimulated by 1, 25 (OH) <SUB>2</SUB>D<SUB>3</SUB>, which incidentally is one of the characters of osteoblasts, it was suggested that HPLF is an osteoblastic. fi broblast. These findings led us to the further characterization of osteoblastic features of HPLF in order to mderstand the physiological function of HPLF.<BR>In this study, the anchorage-independent colony formation assay, biosynthesis of secreted phosphoproteins and gene expression using specific probes (cDNA) of TGF-β, liver/bcne/kidney ALP, 2ar/osteopontin and SPARC/osteonectin were investigated. Human gingival cells (Gin-1), human pulp clone cell (593C1) and rat osteoblastic cells (A<SUB>11</SUB>, ROS17/2.8) were used to compare with HPLF.<BR>The findings were as follows: conditioned media from HPLF were able to induce colony formation similar to that of A<SUB>11</SUB> and ROS17/2.8, indicating that HPLF secreted a TGF-β-like factor. The radio-labeled osteopontins were synthesized with Mrs.45K and 67K in ROS17/2.8, while the proteins were not detected in HPLF. Finally, a higher expression of mRNAs of ALP, TGF-βand SPARC mRNA were revealed in HPLF by the northern blot analysis, but no 2ar mRNA was detected.<BR>In conclusion, these results indicate that HPLF presents osteoblastic characters based on the gene expression of ALP, TGF-βand SPARC. However, the biosynthesis of phosphoprotein was found to be distinct from osteoblastic cells.


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