Researchers Database

YADA Yukari

    CenterforPerinatalandNeonatalMedicine,NeonatalIntensiveCareUnit Associate Professor
Last Updated :2021/12/07

Researcher Information

J-Global ID

Research Interests

  • 新生児医学   小児科学   Neonatology   Pediatrics   

Research Areas

  • Life sciences / Fetal medicine/Pediatrics
  • Life sciences / Fetal medicine/Pediatrics

Association Memberships

  • 日本新生児学会   日本小児循環器学会   日本未熟児新生児学会   日本小児科学会   

Published Papers

  • Ryou Kawamata, Yume Suzuki, Yukari Yada, Yasunori Koike, Yumi Kono, Toshihiko Yada, Naoto Takahashi
    JOURNAL OF PEDIATRIC ENDOCRINOLOGY & METABOLISM 27 (7-8) 717 - 723 0334-018X 2014/07 [Refereed][Not invited]
    Aim: To investigate changes of gut hormones in term and preterm infants in the first 2 months after birth, as the role and relationships of gut hormones in premature infants has not been well elucidated. Methods: In 29 preterm and five term infants, fasting serum concentrations of leptin, glucose-dependent insulinotropic polypeptide (GIP), glucagon-like peptide-1 (GLP-1), peptide YY (PYY), pancreatic polypeptide, insulin, amylin, and ghrelin were measured using a bead array system. Results: Serum leptin concentration soon after birth showed a positive correlation with gestational week in all infants (r=0.623, p<0.01). Serum leptin level rapidly decreased in all infants. In preterm infants, serum GLP-1 levels at birth showed negative correlations with gestational week (r=-0.447, p=0.02). Serum GIP, GLP-1, and PYY levels increased after birth and were persistently high until 10 weeks of life. Conclusion: Serum concentrations of different gut hormones changed postnatally in their specific ways in preterm infants.
  • Noriko Okamoto, Takanori Yamagata, Yukari Yada, Ko Ichihashi, Naomichi Matsumoto, Mariko Y. Momoi, Takeshi Mizuguchi
    BRAIN & DEVELOPMENT 36 (6) 523 - 527 0387-7604 2014/06 [Refereed][Not invited]
    Williams-Beuren syndrome (WBS) is a multisystemic genetic disorder caused by a contiguous gene deletion at 7q11.23. We report a severely affected WBS patient with cerebral and cerebellar dysplasia as well as hypertrophic cardiomyopathy. Microarray comparative genomic hybridization (aCGH) detected a deletion on 7q11.23 expanding from RP11-614D7 to RP11-137E8, which is a typical deletion in WBS. To the best of our knowledge, this is the first case report of a WBS patient with severe congenital central nervous system anomaly and progressive hypertrophic cardiomyopathy. The relationship between the genes deleted in WBS and a CNS anomaly plus hypertrophic cardiomyopathy requires further analysis. (C) 2013 The Japanese Society of Child Neurology. Published by Elsevier B.V. All rights reserved.
  • Satohiko Yanagisawa, Kosaku Maeda, Yuko Tazuke, Yuki Tsuji, Insu Kubota, Yasunori Koike, Yukari Yada, Yumi Kono, Naoto Takahashi, Shigeki Matsubara
    JOURNAL OF OBSTETRICS AND GYNAECOLOGY RESEARCH 39 (5) 974 - 978 1341-8076 2013/05 [Refereed][Not invited]
    Aim Assisted reproductive technology (ART) has increased the incidences of multiple gestations and low birth weights, which frequently warrant pediatric surgery. ART may have also increased the rate of birth defects. In this study, we aimed to determine whether infants conceived after ART required neonatal surgery more frequently compared with naturally conceived infants. Material and Methods Our study population comprised 1891 infants (160 ART (+) and 1731 ART ()) who were admitted to our neonatal intensive care unit during a 5-year period (January 2006December 2010); of these, 198 infants (9 ART (+) and 189 ART ()), with diseases requiring surgery, were referred to pediatric surgeons (consultation cases). We examined the following: (i) factors potentially increasing the requirement for surgery; (ii) frequency of birth defects; and (iii) maternal factors that may increase the need for surgery. Results A significantly higher incidence of multiple gestation and low birth weight was observed in the ART (+) group than the ART () group. However, ART did not yield a higher rate of surgery and birth defects: overall, the rate of surgery was 4% (7/160) in the ART (+) group and 8% (143/1731) in the ART () group. Of 198 consultation cases, the percentage of infants actually requiring surgery was approximately the same in the ART (+) group (7/9 [78%]) and the ART () group (143/189 [76%]). Conclusion Infants conceived after ART comprised a small proportion of neonatal surgery cases, and did not require surgery more frequently.
  • Suzuki H, Kuwata T, Ohkuchi A, Yada Y, Matsubara S, Suzuki M
    Case reports in obstetrics and gynecology 2013 345808  2090-6684 2013 [Refereed][Not invited]
  • Karin Kojima, Naoto Takahashi, Yukari Yada, Yasunori Koike, Miyuki Matano, Yumi Kono, Mariko Y. Momoi
    PEDIATRICS INTERNATIONAL 54 (3) 409 - 412 1328-8067 2012/06 [Refereed][Not invited]
  • Tomoyuki Kuwata, Shigeki Matsubara, Takashi Ohkusa, Yukari Yada, Mitsuaki Suzuki
    JOURNAL OF OBSTETRICS AND GYNAECOLOGY RESEARCH 37 (7) 921 - 925 1341-8076 2011/07 [Refereed][Not invited]
    We highlight the merit of fetal movement count to identify a fetus with neuromuscular disorder: nemaline myopathy. A 38-year-old 1-para woman not in a consanguineous marriage had decreased fetal movement. This, together with increased amniotic fluid volume, led us to perform detailed ultrasound examinations, which revealed stretch contracture of the knee joints, leading us to suspect fetal neuromuscular disorders. At 38(2/7), she gave birth vaginally to a 2444 g female infant. Her respiration was very weak, requiring respiratory support. Contractures of the upper/lower extremity joints and club feet were observed. All skeletal muscles were hypotonic. Biopsized muscle cells showed nemaline bodies, confirming the diagnosis of nemaline myopathy. Fetal movement count may contribute to the identification of fetal neuromuscular diseases, such as nemaline myopathy.
  • Asami Maruyama, Naoto Takahashi, Yuji Gunji, Akira Morimoto, Yukari Yada, Yasunori Koike, Mariko Y. Momoi
    JOURNAL OF PEDIATRIC HEMATOLOGY ONCOLOGY 33 (5) E209 - E212 1077-4114 2011/07 [Refereed][Not invited]
    A preterm infant with very low birth weight was born with fetal onset familial hemophagocytic lymphohistiocytosis. Known gene abnormalities responsible for the disease were not identified in the patient. The infant died at 13 months of age owing to complications from cord blood stem cell transplantation. We found selectively elevated expression of interleukin-6 and chemokines in the cord blood of the patient. We also reviewed 7 other preterm cases of congenital hemophagocytic lymphohistiocytosis to highlight the significance of this condition, as it can cause ascites and hepatosplenomegaly in utero and be mistaken for congenital infection in the fetus.
  • Ryou Kawamata, Naoto Takahashi, Yukari Yada, Yasunori Koike, Yumi Kono, Mariko Y. Momoi
    PEDIATRICS INTERNATIONAL 53 (3) 386 - 388 1328-8067 2011/06 [Refereed][Not invited]
  • Yasunori Koike, Naoto Takahashi, Yukari Yada, Ryou Kawamata, Yuko Sato, Mariko Y. Momoi
    PEDIATRICS 127 (1) E231 - E234 0031-4005 2011/01 [Refereed][Not invited]
    Cow's milk allergy (CMA) in the neonatal period is thought to include several clinical conditions, yet the pathophysiology remains unclear. We report here the case of a term newborn infant who showed hematochezia 36 hours after the first feeding with cow's milk formula. His serum immunoglobulin E levels were not elevated, although eosinophils were detected in the stool. Elimination of cow's milk formula resolved the symptoms, and from the clinical course and laboratory data the infant was diagnosed with CMA. The serum interleukin 5 (IL-5) (125 pg/mL) level in this patient was selectively elevated. However, serum levels of other T-helper 2 (Th2) cytokines (including IL-4 and IL-13), Th1 cytokines (including interferon gamma), and proinflammatory cytokines (including tumor necrosis factor alpha) were not elevated. These findings suggest that, for this patient, IL-5 and eosinophils might have played a role in the development of neonatal CMA. Although this finding is reported from only 1 case, it highlights the need for serum IL-5 to be determined in more neonatal patients with CMA to further clarify the pathophysiology of this condition in the neonatal period. Pediatrics 2011;127:e231-e234
  • Yukari Yada, Yoko Honma, Yasunori Koike, Naoto Takahashi, Mariko Y. Momoi
    PEDIATRICS INTERNATIONAL 52 (5) 718 - 722 1328-8067 2010/10 [Refereed][Not invited]
    Background: The aim of the present study was to investigate the association of chronic lung disease (CLD), neonatal Ureaplasma colonization, and interleukin-8 (IL-8) level of cord blood in preterm infants. Methods: In 77 infants of < 32 weeks gestation, the relationship between IL-8 level of cord blood, neonatal colonization of Ureaplasma, histological chorioamnionitis (CAM), and development of CLD was studied. Results: Five infants died and 29 infants developed CLD. The CLD group had significantly lower gestation (mean +/- SD: 26.6 +/- 1.8 weeks) compared with the infants without CLD (28.9 +/- 1.9 weeks, P < 0.0001). Logistic analysis showed that the development of CLD was associated with gestational age (odds ratio [OR], 0.5; 95% confidence interval (CI): 0.4-0.8) and Ureaplasma colonization (OR, 4.1; 95%CI: 1.2-14.4). Ureaplasma colonization was also associated with CAM (OR, 6.5; 95%CI: 1.8-23.5), absence of respiratory distress syndrome (OR, 6.2; 95%CI: 1.3-30.5), and development of CLD (OR, 4.0; 95%CI: 1.1-15.3). Elevated cord blood IL-8 >= 100 pg/mL was associated with female sex and the isolation of microorganisms (OR, 49.4; 95%CI: 4.6-525). Conclusion: The development of CLD defined by oxygen requirement at 36 weeks was associated with neonatal Ureaplasma colonization but not with IL-8 level of cord blood. Elevated cord blood IL-8 was associated with neonatal microorganisms isolation.
  • Maho Ichikawa, Naoto Takahashi, Yukari Yada, Yasunori Koike, Ryou Kawamata, Yumi Kono, Yoko Honma, Shigeru Yotsumoto, Mariko Y. Momoi
    PEDIATRICS 126 (1) E247 - E250 0031-4005 2010/07 [Refereed][Not invited]
    We present here the unusual case of a male newborn infant who showed progressive severe cholestasis. The infant's gestational age was 37 weeks, and his birth weight was 2134 g. His serum level of direct bilirubin gradually increased from the 6th day of life and reached 257.5 mu mol/L on the 22nd day of life. We could not find any cause for his cholestasis, but his serum level of ferritin was extremely elevated at 9211.0 ng/mL. Because we felt that his clinical condition might be related to hypercytokinemia caused by an immunologic reaction, steroid pulse therapy and cyclosporine were administered. His condition improved, and his direct bilirubin and ferritin levels declined. From the investigation of his cytokine profile, we found a preferentially elevated level of serum interleukin 17 (IL-17) (96.1 pg/mL) and high level of chemokines IL-8 and macrophage inflammatory protein 1 beta. The IL-17 level gradually decreased to 7.5 pg/mL by the 124th day of life. The infant was successfully discharged from the children's hospital but later developed epilepsy at 11 months and asthma at 1 year, 2 months of age. Although we have not yet reached a definitive diagnosis, this case may be the first to show a relationship between cholestasis and an elevated serum IL-17 level in the neonatal period. Pediatrics 2010;126:e247-e250
  • Naoto Takahashi, Ritei Uehara, Mami Kobayashi, Yukari Yada, Yasunori Koike, Ryou Kawamata, Jun Odaka, Yoko Honma, Mariko Y. Momoi
    CYTOKINE 49 (3) 331 - 337 1043-4666 2010/03 [Refereed][Not invited]
    Few papers have investigated the cytokine profiles of multiple cytokines in cord blood. We obtained cord blood samples from 224 infants admitted to our neonatal intensive care unit. Cytokine profiles of 17 cytokines were investigated using cytometric bead array technology. We found a wide variety of cytokines of various levels which ranged from 0.59 pg/ml (in Interleukin (IL-4) to 222.0 pg/ml (in macrophage inflammatory protein-1 beta. Pro-inflammatory cytokines were highly correlated with each other and with granulocyte-colony stimulating factor and IL-8. On the contrary, IL-5, IL-13, and IL-17 did not show any significant correlation with other cytokines. Several maternal factors were strongly related to several cytokines in cord blood. IL-6, IL-8 and monocyte chemotactic protein-1 were closely related to certain neonatal diseases in preterm neonates. Some cytokines may be regulated independently of each other, while others appear to work as a network affecting physiological and pathological conditions in the fetus. (C) 2009 Elsevier Ltd. All rights reserved.
  • Koji Yokoyama, Naoto Takahashi, Yukari Yada, Yasunori Koike, Ryou Kawamata, Ritei Uehara, Yumi Kono, Yoko Honma, Mariko Y. Momoi
    EARLY HUMAN DEVELOPMENT 86 (3) 187 - 191 0378-3782 2010/03 [Refereed][Not invited]
    Background: Magnesium sulfate (MgSO(4)) has been used as a tocolytic agent in cases of refractory preterm labor. Prolonged maternal administration of MgSO(4) may induce bone demineralization in the neonate. However, the effects of MgSO(4) on serum biochemistry related to bone metabolism in neonates remain unclear. Aim: To assess the effects of prolonged maternal administration of MgSO(4) on fetuses and neonates. Study design: This retrospective case-control study examined 167 neonates. Cases comprised 58 neonates whose mothers had received intravenous MgSO(4) administration for > 5 days. Neonatal serum levels of magnesium (Mg), calcium (Ca), phosphorus (P) and alkaline phosphatase (ALP) were reviewed. We also investigated whether subject neonates showed appearance of osteopenia at the metaphyseal lines on radiography at birth. Results: Mean serum Mg and P levels were significantly higher, and Ca levels were significantly lower, in cases than in controls at birth. Mean serum ALP level was 1188.5 IU/l in cases, significantly higher than that in controls at birth. Bone abnormalities were noted on radiography in 2 subjects. By 3 weeks old, serum ALP levels did not differ significantly between cases and controls. Logistic regression analysis revealed maternal administration of MgSO(4) and multiple pregnancies were significantly related to serum ALP level in neonates at birth. Conclusion: Prolonged maternal administration of MgSO(4) significantly affects neonatal serum biochemistry related to bone metabolism. Potential long-term adverse effects on neonates and how Mg affects fetal bone metabolism in utero need to be investigated in future studies. (c) 2010 Elsevier Ireland Ltd. All rights reserved.
  • Mari Saito, Naoto Takahashi, Shigeko Ueda, Yoshihiro Kuwabara, Mami Komiyama, Yasunori Koike, Yukari Yada, Yoko Honma, Mariko Y. Momoi
    PEDIATRICS INTERNATIONAL 52 (1) E34 - E36 1328-8067 2010/02 [Refereed][Not invited]
  • Mami Komiyama, Naoto Takahashi, Yukari Yada, Yasunori Koike, Yoko Honma, Toshinori Aihara, Mariko Momoi
    EARLY HUMAN DEVELOPMENT 85 (4) 267 - 270 0378-3782 2009/04 [Refereed][Not invited]
    Background: Very low birth weight (VLBW) infants sometimes develop abdominal distension and poor weight gain. The influence of thyroid function on these symptoms in VLBW infants has not been reported. Methods: In a retrospective study, 18 VLBW infants whose abdominal distension and poor weight gain did not: improve with standard treatment were enrolled as subjects. Serum levels of free thyroxin (fT(4)) and thyroid stimulating hormone (TSH) were measured. Subjects with serum fT(4) levels less than 1.3 ng/dl received thyroxin supplementation. Another 18 VLBW infants were recruited as age- and weight-matched controls. We compared degree of intestinal dilation on X-ray, weight gain, and quantity of milk tolerated before and after starting thyroxin supplementation in the subjects and the controls. Results: All subjects had serum fT(4) levels less than 1.3 ng/dl (mean, 0.72 ng/dl). TSH values varied widely and were less than 8 mu U/ml in 12 subjects. Therefore, all subjects received thyroxin supplementation; after starting this, mean serum fT(4) level increased significantly to 1.31 ng/dl. In parallel with fT(4) increase, intestinal dilation improved in 16 of 18 subjects (mean grade of dilation decreased from 2.8 to 1.6). Weight gain and quantity of tolerated milk were significantly increased with thyroxin supplementation in all and 17 of the 18 subjects, respectively. Conclusions: Thyroxin supplementation was effective in improving abdominal symptoms in VLBW infants whose serum fT(4) level was less than 1.3 ng/dl. (C) 2008 Elsevier Ireland Ltd. All rights reserved.
  • Naoto Takahashi, Hisaya Hasegawa, Mami Komiyama, Takehiro Ohki, Yukari Yada, Yasunori Koike, Ryou Kawamata, Yoko Honma, Mariko Momoi
    CYTOKINE 45 (1) 39 - 43 1043-4666 2009/01 [Refereed][Not invited]
    Neonatal toxic shock syndrome (TSS)-like exanthematous disease (NTED) is an emerging neonatal infectious disease caused by TSS toxin-1 (TSST-1). Although NTED and TSS are caused by the same superantigenic exotoxin, NTED is less severe than TSS. The mechanism of this reduced severity in NTED has not been elucidated. Thirteen patients with NTED were enrolled in the study. We investigated serum cytokine profile using a cytometric bead array system with a cytokine panel. Expression of V beta 2 and CD45RO in CD4(+)T cells was investigated in mononuclear cells by using flow cytometry. Ten patients with other bacterial infections and eight patients without any infections were also enrolled as control groups. The mean serum level of IL-10 was 1209.9 pg/mL in patients with NTED at the time of admission into the study. The other inhibitory cytokine, IL-4, exhibited a minimum level. The high level of IL-10 rapidly decreased within 3-9 days of the onset of NTED. The cytokine profile of NTED, with its high IL-10 level, was clearly different from that of the other bacterial infections. The increased level of IL-10 seems to be related to the reduced severity of NTED. Th2 shift is not thought to be the cause of this IL-10 excretion. (C) 2008 Elsevier B.V. All rights reserved.
  • Kou Ichihashi, Yukari Yada, Naoto Takahashi, Yoko Homrna, Mariko Momoi
    JOURNAL OF PERINATAL MEDICINE 36 (3) 253 - 255 0300-5577 2008 [Refereed][Not invited]
    We measured integrated backscatter (IBS) in the brain of preterm infants using acoustic ultrasound. The study group consisted of 25 preterm infants (gestational age, 32.4 +/- 2.5 Weeks; birth weight, 1488 +/- 422 g). In parasagittal scans through the posterior horn of the lateral ventricle, regions of interest (ROI) were positioned in the cerebral white matter near the posterior horn (P), anterior horn (A) of the lateral ventricle, and the thalamus (T). IBS of the ROI was measured and IBS of P minus T (P-T) and IBS of A, minus T (A-T) were calculated. A-T was greater than P-T A-T and P-T decreased with increasing gestational age and birth weight. These changes may represent maturation of the cerebrum. A-T or P-T may be useful parameters of cerebral tissue characterization.
  • Yoko Honma, Yukari Yada, Naoto Takahashi, Mariko Y. Momoi, Yoshikazu Nakamura
    PEDIATRICS INTERNATIONAL 49 (4) 479 - 484 1328-8067 2007/08 [Refereed][Not invited]
    Background: Recent studies of chronic lung disease (CLD) of newborns emphasize the contribution of antenatal infection. However, the association of Ureaplasma urealyticum infection and CLD has been controversial. The purpose of the present paper was to determine whether U. urealyticum is associated with chorioamnionitis (CAM) and a certain type of CLD. Methods: One hundred and five infants < 32 weeks of gestation who were admitted to the neonatal intensive care unit at Jichi Medical School Hospital, who underwent both histological and microbiological examinations and who survived to discharge were included. CAM was determined by histological examination. Placenta, gastric and tracheal aspirates, and nasopharyngeal swabs were cultured for Mycoplasma and other microorganisms. CLD was defined as oxygen needed at 28 days of age with symptoms of persistent respiratory distress and hazy or emphysematous and fibrous appearance upon X-ray. CLD was further divided into two subtypes according to the presence of antenatal infection. Results: CAM was associated with premature rupture of membrane (odds ratio [OR], 10.19; 95% confidence interval [CI]: 3.10-33.56), placental colonization of U. urealyticum (OR 6.73, 95% CI: 1.89-23.91), neonatal colonization of other microorganisms (OR 7.33, 95% CI: 1.22-44.13) and level of IgM (OR 1.06, 95% CI: 1.01-1.11). Comparisons between CLD and non-CLD patients showed that gestational age (OR 0.43, 95% CI: 0.30-0.61) and white blood cell count (WBC) at birth (OR 1.06, 95% CI: 1.01-1.11) were risk factors for CLD, while gestational age (OR 0.38, 95% CI: 0.23-0.64), neonatal colonization of U. urealyticum (OR 5.98, 95% CI: 1.17-30.6) and WBC (OR 1.08, 95% CI: 1.01-1.15) were independent risk factors for infection-related CLD compared with non-CLD. Within CLD, infection-related CLD was associated with neonatal colonization of U. urealyticum (OR 43.7, 95% CI: 2.84-673.8) and WBC (OR 1.27, 95% CI: 1.07-1.50). Conclusions: Placental colonization of U. urealyticum was significantly related to CAM; and neonatal colonization of U. urealyticum and leukocytosis at birth were risk factors for infection-related CLD.
  • R Aoki, Y Honma, Y Yada, MY Momoi, S Iwamoto
    HUMAN REPRODUCTION 21 (3) 735 - 737 0268-1161 2006/03 [Refereed][Not invited]
    A case of monochorionic twin boys delivered at 34 weeks of gestation following induced ovulation with clomiphene is described. One twin was typed as blood group AB and the other as B. Flow cytometry showed blood group chimerism. DNA polymorphism analysis of peripheral lymphocytes and hair root cells showed that the chimerism was confined to the blood cells and they were dizygotic.
  • K Ichihashi, Y Yada, N Takahashi, Y Honma, M Momoi
    JOURNAL OF PERINATAL MEDICINE 33 (6) 549 - 552 0300-5577 2005/12 [Refereed][Not invited]
    The purpose of this study was to assess cardiac function of newborns with mild asphyxia by a Doppler-derived index combining systolic and diastolic performance (Tei index). We studied 20 preterm infants with mild asphyxia. A control group consisted of 20 gestational age-matched preterm infants without asphyxia. Echocardiograms were performed during the fourth and seventh days after birth. Peak velocities of an early filling wave ( E) and an atrial contraction wave ( A) were measured from the mitral inflow velocity profile and the ratio of peak E to A was calculated. Ejection time was measured from the left ventricular outflow Doppler signal. The sum of isovolumetric times was obtained by subtracting the ejection time from the interval between cessation and onset of mitral inflow. The index was the sum of isovolumetric times divided by ejection time. Ejection fraction was also calculated. The ratio of peak E to A and ejection fraction were the same in both groups. The myocardial performance index in patients with asphyxia was higher than that in patients without asphyxia. We concluded that patients with mild asphyxia have a mild cardiac dysfunction and this change can be detected by a myocardial performance index.
  • Kuwata T, Matsubara S, Ohkuchi A, Watanabe T, Izumi A, Honma Y, Yada Y, Shibahara H, Suzuki M
    Twin research : the official journal of the International Society for Twin Studies 3 7 223 - 227 1369-0523 2004/06 [Refereed][Not invited]


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