Researchers Database

ikeda tarou

    Professor
Last Updated :2021/12/08

Researcher Information

Research funding number

  • 00318396

J-Global ID

Research Interests

  • 脱分化脂肪細胞(DFAT)   壊死性腸炎   小児固形腫瘍 腫瘍感受性遺伝子 小児肝癌   腸音図 消化管機能   小児鼠径ヘルニア 対側発症   脱分化脂肪細胞 再生医学 排便機能   術後排便機能   小児排便異常   直腸肛門奇形   再生医療   排便機能   消化管機能   小児外科   

Research Areas

  • Life sciences / General surgery, pediatric surgery
  • Life sciences / Digestive surgery
  • Life sciences / Clinical pharmacy
  • Life sciences / Physiology

Academic & Professional Experience

  • 2016/11 - Today  Jichi Medical University准教授
  • 2014/04 - 2016/10  Jichi Medical University総合医学第2講座講師
  • 1998/04 - 2014/03  日本大学医学部外科学講座小児外科部門助教・医長
  • 1997/06 - 1998/03  板橋区医師会病院外科
  • 1996/06 - 1997/05  社会保険横浜中央病院外科
  • 1995/12 - 1996/05  那須中央病院外科
  • 1994/12 - 1995/11  春日部市立病院外科
  • 1993/05 - 1994/11  日本大学医学部第一外科学教室

Education

  •        - 1993  Nihon University  Faculty of Medicine  医学

Association Memberships

  • 日本小児泌尿器科学会   日本小児外科学学会   日本外科学会   日本消化器外科学会   日本臨床外科学会   日本外科系連合学会   日本大腸肛門病学会   日本周産期・新生児学会   日本小児放射線学会   日本小児救急医学会   日本再生医療学会   

Published Papers

  • Shigeki Ishioka, Takashi Hosokawa, Taro Ikeda, Noriyoshi Konuma, Hide Kaneda, Kensuke Ohashi, Takeshi Furuya, Takayuki Masuko, Hiroaki Taniguchi, Koichiro Kano, Tsugumichi Koshinaga, Taro Matsumoto
    Pediatric Surgery International 36 (7) 799 - 807 0179-0358 2020/07 
    © 2020, The Author(s). Purpose: Our previous studies demonstrated that mature adipocyte-derived dedifferentiated fat (DFAT) cells possess similar multipotency as mesenchymal stem cells. Here, we examined the immunoregulatory potential of DFAT cells in vitro and the therapeutic effect of DFAT cell transplantation in a mouse inflammatory bowel disease (IBD) model. Methods: The effect of DFAT cell co-culture on T cell proliferation and expression of immunosuppression-related genes in DFAT cells were evaluated. To create IBD, CD4+CD45RBhigh T cells were intraperitoneally injected into SCID mice. One week later, DFAT cells (1 × 105, DFAT group) or saline (Control group) were intraperitoneally injected. Subsequently bodyweight was measured every week and IBD clinical and histological scores were evaluated at 5 weeks after T cell administration. Results: The T cell proliferation was inhibited by co-cultured DFAT cells in a cell density-dependent manner. Gene expression of TRAIL, IDO1, and NOS2 in DFAT cells was upregulated by TNFα stimulation. DFAT group improved IBD-associated weight loss, IBD clinical and histological scores compared to Control group. Conclusion: DFAT cells possess immunoregulatory potential and the cell transplantation promoted recovery from colon damage and improved clinical symptoms in the IBD model. DFAT cells could play an important role in the treatment of IBD.
  • Shigeki Ishioka, Takashi Hosokawa, Taro Ikeda, Noriyoshi Konuma, Hide Kaneda, Kensuke Ohashi, Takeshi Furuya, Takayuki Masuko, Hiroaki Taniguchi, Koichiro Kano, Tsugumichi Koshinaga, Taro Matsumoto
    Pediatric surgery international 36 (7) 799 - 807 2020/07 
    PURPOSE: Our previous studies demonstrated that mature adipocyte-derived dedifferentiated fat (DFAT) cells possess similar multipotency as mesenchymal stem cells. Here, we examined the immunoregulatory potential of DFAT cells in vitro and the therapeutic effect of DFAT cell transplantation in a mouse inflammatory bowel disease (IBD) model. METHODS: The effect of DFAT cell co-culture on T cell proliferation and expression of immunosuppression-related genes in DFAT cells were evaluated. To create IBD, CD4+CD45RBhigh T cells were intraperitoneally injected into SCID mice. One week later, DFAT cells (1 × 105, DFAT group) or saline (Control group) were intraperitoneally injected. Subsequently bodyweight was measured every week and IBD clinical and histological scores were evaluated at 5 weeks after T cell administration. RESULTS: The T cell proliferation was inhibited by co-cultured DFAT cells in a cell density-dependent manner. Gene expression of TRAIL, IDO1, and NOS2 in DFAT cells was upregulated by TNFα stimulation. DFAT group improved IBD-associated weight loss, IBD clinical and histological scores compared to Control group. CONCLUSION: DFAT cells possess immunoregulatory potential and the cell transplantation promoted recovery from colon damage and improved clinical symptoms in the IBD model. DFAT cells could play an important role in the treatment of IBD.
  • Kensuke Ohashi, Tsugumichi Koshinaga, Shuichiro Uehara, Takeshi Furuya, Hide Kaneda, Hiroyuki Kawashima, Taro Ikeda
    JOURNAL OF PEDIATRIC SURGERY 52 (11) 1873 - 1877 0022-3468 2017/11 [Refereed][Not invited]
     
    Objective: In recent years, improved survival rates of extremely low birth weight infants (ELBWIs) have led to an increasing number of enterostomy performed for those with meconium obstruction of prematurity (MOP)(1,2), spontaneous intestinal perforation (SIP)(3,4). To prevent serious stoma-related complications such as stoma side perforation, prolapse, fall and surgical site infection, we introduce our new "sutureless enterostomy" technique. Methods: We present the procedures in detail. We reviewed the medical records of twelve patients who underwent "sutureless enterostomy" in our neonatal intensive care unit from 2007 to 2013. Patient attributes, surgery-related items, stoma-related complications and outcomes were investigated. Results: Mean birth weight was 671 +/- 158 g (mean +/- S.D.). Six cases of MOP, three cases of SIP and three cases of NEC were diagnosed. Mean operative time was 75 +/- 35 min (mean +/- S.D.) None of them presented any of early stoma-related complications (necrosis, fall, and surgical site infection). However the parastomal hernia occurred in one patient as late complication. Three deaths occurred postoperatively as a result of exacerbations of their conditions. Conclusions: Based on our preliminary observations, our new "sutureless enterostomy" was done safely and reduced the risk of stoma-related complications. It may be an ideal procedure for the ELBWI with MOP or SIP. (C) 2017 Elsevier Inc. All rights reserved.
  • 後藤 俊平, 池田 太郎, 前岡 瑛里, 小野 賀功, 花田 学, 古屋 武史, 細田 利史, 杉藤 公信, 越永 従道
    小児外科 (株)東京医学社 47 (12) 1310 - 1313 0385-6313 2015/12 
    6歳女児。間欠的腹痛と非胆汁性嘔吐を主訴とした。5歳時に卵管留水腫を伴う卵管捻転に対し捻転解除および卵管開口術を施行し、外来フォロー中であった。腹部超音波検査にて腸間膜リンパ節の軽度腫大を認め、骨盤CTでは骨盤内直腸腹側に径4cm大のlow density massを認めたが、明らかな造影効果は認めなかった。右卵管捻転の再発を疑いで緊急手術を施行し、右卵管は卵管膨大部で反時計方向に360度の捻転を起こしていたが、卵巣には異常を認めなかった。卵管捻転の原因となる器質的異常は認めず、捻転解除後、卵巣を子宮後壁に吸収糸を用いて固定した。術後経過は良好で第3病日に退院し、固定術後3年経過して再発は認めていない。
  • 消化管穿孔を疑ったらクロステーブルラテラール撮影を忘れるべからず
    池田 太郎
    周産期医学 45 (増刊) 565 - 567 2015/12 [Not refereed][Not invited]
  • Takeshi Furuya, Mikiya Inoue, Kiminobu Sugito, Shumpei Goto, Hiroyuki Kawashima, Hide Kaneda, Takayuki Masuko, Kensuke Ohashi, Taro Ikeda, Tsugumichi Koshinaga
    INDIAN JOURNAL OF SURGERY 77 S1041 - S1044 0972-2068 2015/12 [Refereed][Not invited]
     
    The management of patients with acute perforated appendicitis with abscess is controversial. The aim of the present study was to assess the outcomes of treatment in patients with this condition. We retrospectively analyzed 31 patients (16 men and 15 women with a mean age of 8.4 years) with appendicitis presenting with abscess. Patients were divided into two groups (emergency operation group and interval operation group), and clinical characteristics and outcomes of treatment were investigated. On presentation, no differences in gender, age, body weight, duration of symptoms, temperature, white blood cell count, C-reactive protein level, or maximum size of the abscess in the axial view were detected between the two groups. Fifteen patients (48.4 %) underwent emergency surgery. The remaining 16 patients (51.6 %) were initially treated conservatively with antibiotics. All 16 patients underwent planned operations after receiving conservative treatment, and two (12.5 %) of these patients underwent appendectomy before the planned operation day because of recurrent appendicitis without abscess. There were no differences in the length of hospital stay. In the emergency operation group, six (40 %) patients presented with wound infection and four (26.7 %) developed a postoperative intra-abdominal abscess. No infective complications were reported in the interval operation group. Interval appendectomy after conservative treatment of pediatric ruptured appendicitis with abscess significantly reduced postoperative infection rates.
  • Hanada M, Furuya T, Sugito K, Ohashi K, Ikeda T, Koshinaga T, Kawashima H, Inoue M, Hosoda T, Goto H
    Surgery today 45 (11) 1385 - 1389 0941-1291 2015/11 [Refereed][Not invited]
     
    PURPOSE: We retrospectively compared the short-term outcomes between incision and drainage (ID) and hainosankyuto (TJ-122, Tsumura & Co, Tokyo, Japan) treatment for perianal abscess (PA) in infants. METHODS: We retrospectively examined 48 consecutive patients (median age 129 days; range 19-330 days) who presented with PA over a 3 year period. Group 1 comprised 26 patients who were treated with ID at presentation, and Group 2 comprised 22 patients who were treated with oral TJ-122 at presentation; oral treatment was continued until the disappearance of purulent discharge and resolution of induration at the abscess site. RESULTS: PAs were identified in all 48 patients at presentation. The median duration of follow-up was 26 months (range 13-40 months). At presentation, there were no differences in the gender, age, birth weight, duration of symptoms, skin erosion or prevalence of diarrhea between the two groups. Purulent discharge resolved within a median period of 26 days (range 7-42 days) in Group 2, but persisted for 40 days (range 4-196 days) in Group 1. The induration resolved within a median period of 39 days (range 7-91 days) in Group 2, but persisted for 70 days (range 4-308 days) in Group 1 (p = 0.04). CONCLUSIONS: TJ-122 treatment was more beneficial than ID in treating PA in infants.
  • 母乳の飲みはよいのに3日間便がでないのですが
    池田 太郎
    周産期医学 45 (11) 1622 - 1623 2015/11 [Not refereed][Not invited]
  • うんちの色が白くなってきたのですが
    池田 太郎
    周産期医学 45 (11) 1620 - 1621 2015/11 [Not refereed][Not invited]
  • 白線ヘルニアに手術は必要か
    池田 太郎
    小児外科 47 (10) 1023 - 1026 2015/10 [Not refereed][Not invited]
  • Takashi Hosokawa, Noriyoshi Konuma, Taro Ikeda, Makoto Hashimoto, Hide Kaneda, Kensuke Ohashi, Taro Matsumoto, Tsugumichi Koshinaga
    JOURNAL OF PEDIATRIC SURGERY 50 (8) 1352 - 1358 0022-3468 2015/08 [Refereed][Not invited]
     
    Background/purpose: Mainstreammodels for anal sphincter injury use large animals. We developed a simple and stable anal sphincter injury model in a small animal (i.e., rats) to obtain manometry measurements by using a miniaturized probe and applying cardiotoxin. Methods: The histological structure of the anal canal was evaluated by using manometry in normal rats (n = 40). We damaged the internal and external anal sphincters by locally administering snake poison (cardiotoxin; 20 uM, 100 mu L 8 points). We evaluated the anal canal function through manometry measurements (n = 5) and examined the histology using hematoxylin-eosin staining (at each time point, n = 3; total n = 15). Results: The manometry parameters and structure of the anal canal of normal rats were similar to those of humans, because rats have resting pressure, rectoanal reflex in the manometry, and an external and internal anal sphincter. After inducing injury, the following findings were observed: rhythmic wave loss and a remarkable reduction in the anal sphincter resting pressure; and local bleeding and advanced infiltration of the inflammatory cells (day 1) and the loss of muscle fibers (day 3). Conclusion: This new rat model will contribute to increasing the knowledge on the anal canal. (C) 2015 Elsevier Inc. All rights reserved.
  • H. Kaneda, T. Furuya, K. Sugito, S. Goto, H. Kawashima, M. Inoue, T. Hosoda, T. Masuko, K. Ohashi, T. Ikeda, T. Koshinaga, M. Hoshino, H. Goto
    HERNIA 19 (4) 595 - 598 1265-4906 2015/08 [Refereed][Not invited]
     
    The current study aimed to verify the usefulness of preoperative ultrasonographic evaluation of contralateral patent processus vaginalis (PPV) at the level of the internal inguinal ring. This was a prospective study of patients undergoing unilateral inguinal hernia repair at two institutions during 2010-2011. The sex, age at initial operation, birth weight, initial operation side, and the preoperative diameter of the contralateral PPV as determined using ultrasonography (US) were recorded. We analyzed the incidence of contralateral inguinal hernia, risk factors, and the usefulness of the preoperative major diameter of the contralateral PPV. The follow-up period was 36 months. All 105 patients who underwent unilateral hernia repair completed 36 months of follow-up, during which 11 patients (10.5 %) developed a contralateral hernia. The following covariates were not associated with contralateral hernia development: sex (p = 0.350), age (p = 0.185), birth weight (p = 0.939), and initial operation side (p = 0.350). The preoperative major diameter of the contralateral PPV determined using US was significantly wider among patients with a contralateral hernia than those without a contralateral hernia (p = 0.001). When the 105 patients were divided into two groups according to cut-off values of the preoperative major diameter of the contralateral PPV (wide group, > 2.0 mm; narrow group, a parts per thousand currency sign2.0 mm), a significant association was observed between the preoperative major diameter of the contralateral PPV and patient outcomes (p = 0.001). We used US and confirmed the usefulness of a preoperative evaluation of the major diameter of the contralateral PPV at the level of the internal inguinal ring in pediatric patients with unilateral inguinal hernias.
  • 鈍的腎外傷後仮性動脈瘤に対し、塞栓術を先行し腎摘出を行った小児の一例
    前岡 瑛里, 古屋 武史, 花田 学, 池田 太郎, 小野 賀功, 後藤 俊平, 細田 利史, 大橋 研介, 杉藤 公信, 越永 従道
    日大医学雑誌 日本大学医学会 74 (3) 143 - 143 0029-0424 2015/06
  • 石塚 悦昭, 杉藤 公信, 小野 賀功, 平野 隆幸, 蘇我 晶子, 後藤 俊平, 花田 学, 石岡 茂樹, 川島 弘之, 細田 利史, 大橋 研介, 井上 幹也, 池田 太郎, 越永 従道
    日本小児外科学会雑誌 (一社)日本小児外科学会 51 (3) 669 - 669 0288-609X 2015/05
  • 花田 学, 杉藤 公信, 池田 太郎, 井上 幹也, 大橋 研介, 星野 真由美, 後藤 博志, 細田 利史, 浅井 陽, 川島 弘之, 古屋 武史, 越永 従道
    日本小児外科学会雑誌 (一社)日本小児外科学会 51 (2) 307 - 308 0288-609X 2015/04 [Refereed][Not invited]
  • 前岡 瑛里, 花田 学, 古屋 武史, 池田 太郎, 小野 賀功, 後藤 俊平, 細田 利史, 大橋 研介, 杉藤 公信, 越永 従道
    日本小児外科学会雑誌 (一社)日本小児外科学会 51 (1) 151 - 151 0288-609X 2015/02
  • Ryouichi Tomita, Kiminobu Sugitou, Kenichi Sakurai, Shigeru Fujisaki, Taro Ikeda, Tsugumichi Koshinaga
    INTERNATIONAL SURGERY 99 (6) 699 - 704 0020-8868 2014/11 [Refereed][Not invited]
     
    To clarify the physiologic function of the enteric nervous system (ENS) in the elongated sigmoid colon (ESC) of patients with sigmoid volvulus (SV), we examined the enteric nerve responses in lesional and normal longitudinal muscle strips (LMS) derived from patients with ESC and patients who underwent colon resection for colonic cancers. Thirty preparations of LMS were taken from the lesional sigmoid colons of 10 ESC patients with SV (8 men and 2 women, aged 53 to 80 years, mean 66.2 years). Forty preparations of LMS were taken from the normal sigmoid colons (NSC) of 20 patients with colonic cancer (12 men and 8 women, aged 55 to 76 years, mean 62.3 years). A mechanographic technique was used to evaluate in vitro muscle responses to electrical field stimulation (EFS) before and after treatment with various autonomic nerve blockers. Response to EFS before blockade of the adrenergic and cholinergic nerves was as follows: NSC and ESC significantly demonstrated relaxation reaction rather than contraction reaction (P = 0.0253, P < 0.0001, respectively). ESC showed relaxation reaction more than NSC (P = 0.1138). Response to EFS after blockade of the adrenergic and cholinergic nerves was as follows: NSC and ESC significantly demonstrated relaxation reaction via nonadrenergic noncholinergic (NANC) inhibitory nerves rather than contraction reaction via NANC excitatory nerves (P < 0.0001, P < 0.0001, respectively). ESC with SV significantly showed relaxation reaction more than NSC (P = 0.0092). An increased response of relaxation mediated NANC inhibitory nerves may play a role in impaired motility in the ESC of patients with SV.
  • Tomita R, Fujisaki S, Sakurai K, Park E, Inoue M, Sugito K, Ikeda T, Koshinaga T
    Gan to kagaku ryoho. Cancer & chemotherapy 41 (12) 1689 - 1691 0385-0684 2014/11 [Refereed][Not invited]
     
    PURPOSE: To investigate the clinical findings of patients who underwent surgery for small bowel obstruction following a previous operation for colorectal cancer. We assessed consecutive patients operated on for peritoneal metastasis with small bowel ileus. PATIENTS AND METHODS: We evaluated the clinical characteristics of 7 consecutive patients with malignant small bowel ileus due to recurrent colorectal cancer with peritoneal metastasis. RESULTS: 1) Primary cancer location: descending colon, 2 cases (28.6%); sigmoid colon, 1 case (14.3%); and rectum, 4 cases (57.1%). 2) Peritoneal dissemination grade: P2, 1 case (14.3%); and P3, 6 cases (85.7%). 3) Liver metastasis grade: H1, 1 case (14.3%); H2, 5 cases (71.4%); and H3, 1 case (14.3%). 4) Lymph node metastasis grade: N2, 1 case (14.3%); and N3, 6 cases (85.7%). 5) Extra-abdominal metastasis: multiple lung metastases were detected in 3 cases (42.9%). 6) Pathological type: moderately differentiated tubular adenocarcinoma (tub2), 3 cases (42.3%); poorly differentiated adenocarcinoma (por), 1 case (14.3%); and mucinous adenocarcinoma (muc), 3 cases (42.3%). The differentiated type (tub2) was more common than the undifferentiated types(por and muc). 7) Malignant small bowel stenosis and/or obstruction: there were 3 or more cases with stenosis and/or obstruction in jejunum and ileum. 8) OPERATIVE PROCEDURE: gastrostomy was performed in 2 cases (28.6%); nephrostomy was performed in 1 case (14.3%); gastrostomy with nephrostomy was performed in 1 case (14.3%); and probe laparotomy was performed in 3 cases (42.9%). 9) Survival time of patients with recurrent colorectal cancer, from readmission to death: 0.5-1 month, 3 cases (42.9%); 1-1.5 months, 3 cases (42.9%); and 1.5-3 months, 1 case (14.3%). All patients died in less than 3 months. CONCLUSIONS: The prognosis of the malignant small bowel ileus due to recurrent colorectal cancer with peritoneal metastasis is very bad.
  • 便失禁をともなう便秘症の治療
    池田 太郎
    小児外科 46 (9) 966 - 969 2014/09 [Not refereed][Not invited]
  • 臍ヘルニア・臍突出症に対する新術式 深い臍を作るための工夫
    細田 利史, 大橋 研介, 杉藤 公信, 池田 太郎, 越永 従道
    日大医学雑誌 日本大学医学会 73 (3) 168 - 168 0029-0424 2014/06
  • 胎児期に発症した小腸捻転症の2例
    小野 賀功, 大橋 研介, 後藤 俊平, 花田 学, 細田 利史, 杉藤 公信, 池田 太郎, 越永 従道
    日大医学雑誌 日本大学医学会 73 (3) 169 - 170 0029-0424 2014/06
  • 非触知精巣の治療ガイドラインとその実際
    古屋 武史, 佐藤 亜耶, 川島 弘之, 金田 英秀, 細田 利史, 益子 貴之, 大橋 研介, 杉藤 公信, 池田 太郎, 多田 実, 越永 従道
    日大医学雑誌 日本大学医学会 73 (3) 173 - 174 0029-0424 2014/06
  • 鈍的腎外傷後仮性動脈瘤を認め、塞栓術後に腎摘した小児の1例
    前岡 瑛里, 古屋 武史, 花田 学, 池田 太郎, 小野 賀功, 後藤 俊平, 細田 利史, 大橋 研介, 杉藤 公信, 越永 従道
    日本小児放射線学会雑誌 (一社)日本小児放射線学会 30 (Suppl.) 40 - 40 0918-8487 2014/06
  • 渡邉揚介, 池田太郎, 大橋研介, 小野賀功, 橋本真, 金田英秀, 古屋武史, 井上幹也, 杉藤公信, 越永従道
    日小外会誌 54 (4) 831 - 837 2014/06 [Refereed][Not invited]
  • M. Hoshino, K. Sugito, H. Kawashima, S. Goto, H. Kaneda, T. Furuya, T. Hosoda, T. Masuko, K. Ohashi, M. Inoue, T. Ikeda, R. Tomita, T. Koshinaga
    HERNIA 18 (3) 333 - 337 1265-4906 2014/06 [Refereed][Not invited]
     
    Previously, we established a pre-operative risk scoring system to predict contralateral inguinal hernia in children with unilateral inguinal hernias. The current study aimed to verify the usefulness of our pre-operative scoring system. This was a prospective study of patients undergoing unilateral inguinal hernia repair from 2006 to 2009 at a single institution. Gender, age at initial operation, birth weight, initial operation side, and the pre-operative risk score were recorded. We analyzed the incidence of contralateral inguinal hernia, risk factors, and the usefulness of our pre-operative risk scoring system. The follow-up period was 36 months. We used forward multiple logistic regression analysis to predict contralateral hernia. Of the 372 patients who underwent unilateral hernia repair, 357 (96.0 %) were completely followed-up for 36 months, and 23 patients (6.4 %) developed a contralateral hernia. Left-sided hernia (OR = 5.5, 95 %, CI = 1.3-24.3, p = 0.023) was associated with an increased risk of contralateral hernia. The following covariates were not associated with contralateral hernia development: gender (p = 0.702), age (p = 0.215), and birth weight (p = 0.301). The pre-operative risk score (cut-off point = 4.5) of the patients with a contralateral hernia was significantly higher, compared with the patients without a contralateral hernia using the area under the receiver operating characteristic curve (p = 0.024). Using multivariate analysis, we confirmed usefulness of our pre-operative scoring system and initial side of the inguinal hernia, together, for the prediction of contralateral inguinal hernia in children.
  • Shota Uekusa, Hiroyuki Kawashima, Kiminobu Sugito, Shinsuke Yoshizawa, Yui Shinojima, Jun Igarashi, Srimoyee Ghosh, Xaofei Wang, Kyoko Fujiwara, Taro Ikeda, Tsugumichi Koshinaga, Masayoshi Soma, Hiroki Nagase
    INTERNATIONAL JOURNAL OF ONCOLOGY 44 (5) 1669 - 1677 1019-6439 2014/05 [Refereed][Not invited]
     
    Aberrant methylation of Nr4a3 exon 3 CpG island (CpGi) was initially identified during multistep mouse skin carcinogenesis. Nr4a3 is also known as a critical gene for neuronal development. Thus, we examined the Nr4a3 exon 3 CpGi methylation in mouse brain tissues from 15-day embryos, newborns and 12-week-old adults and found significant increase of its methylation and Nr4a3 expression during mouse brain development after birth. In addition, homologous region in human genome was frequently and aberrantly methylated in neuroblastoma specimens. A quantitative analysis of DNA methylation revealed that hypomethylation of CpG islands on NR4A3 exon 3, but not on exon 1 was identified in three neuroblastomas compared with matched adrenal glands. Additional analysis for 20 neuroblastoma patients was performed and 8 of 20 showed hypomethylation of the CpGi on NR4A3 exon 3. The survival rate of those 8 patients was significantly lower compared with those in patients with hypermethylation. Immunohistochemical NR4A3 expression was generally faint in neuroblastoma tissues compared with normal tissues. Moreover, the MYCN amplified NB9 cell line showed hypomethylation and low expression of NR4A3, while the non-MYCN amplified NB69 cell line showed hypermethylation and high expression. These results indicate that DNA hypomethylation of the CpGi at NR4A3 exon 3 is associated with low NR4A3 expression, and correlates with poor prognosis of neuroblastoma. Since NR4A3 upregulation associated with the hypermethylation and neuronal differentiation in mice, poor prognosis of neuroblastoma associated with NR4A3 low expression may be partly explained by dysregulation of its differentiation.
  • 星 玲奈, 杉藤 公信, 渡邉 揚介, 吉澤 信輔, 植草 省太, 川島 弘之, 後藤 俊平, 大橋 研介, 池田 太郎, 越永 従道
    日本小児外科学会雑誌 50 (2) 257 - 262 2014/04 [Refereed][Not invited]
  • Mikiya Inoue, Kiminobu Sugito, Taro Ikeda, Hiroyuki Kawashima, Manabu Hanada, Takeshi Furuya, Kensuke Ohashi, Tsugumichi Koshinaga
    JOURNAL OF GASTROINTESTINAL SURGERY 18 (3) 580 - 583 1091-255X 2014/03 [Refereed][Not invited]
     
    Background The present study aimed to assess the long-term results of seton placement for fistula-in-ano (FIA) in infants. Methods Data of patients aged < 1 year who presented to our department with perianal abscess (PA) between January 2006 and February 2010 were retrospectively reviewed. Our standard initial treatment for PA was incision and drainage. Patients with systemic diseases and inflammatory bowel diseases were excluded. Results Ninety-five patients were treated for PA and/or FIA during the 5-year period, and follow-up data were available for 90 patients. The mean follow-up duration in these patients was 49.8 + 11.4 months, and mean age at presentation was 3.1 + 2.7 months. Of the 90 patients, 36 (40 %) developed FIA (39 lesions) and underwent seton placement. The condition healed in a mean period of 6.3 + 4.0 weeks after the placement of a cutting seton. Healing of the fistula was achieved in 35 (97.2%) of 36 patients after the initial seton procedure, and one patient who showed recurrence underwent a second seton placement, resulting in successful healing of the FIA after 5 weeks. Conclusions The long-term success of seton placement indicates that this procedure should be a treatment option for FIA in infants.
  • 豊胸術後に認められた右乳房生理食塩水バッグ破裂に左乳癌を伴った症例について
    富田 凉一, 藤崎 滋, 櫻井 健一, 朴 英智, 井上 幹也, 杉藤 公信, 池田 太郎, 越永 従道
    Therapeutic Research 35 (3) 313 - 317 2014/03 [Refereed][Not invited]
  • 中間位・高位鎖肛術後の便秘に対する再手術
    池田太郎, 大橋研介, 杉藤公信, 越永従道
    小児外科 46 (1) 49 - 52 2014/01 [Not refereed][Not invited]
  • Atsuyuki Yamataka, Yasuhide Morikawa, Makoto Yagi, Osamu Kimura, Tatsuo Kuroda, Yutaka Kanamori, Hideaki Tanaka, Masataka Takahashi, Shigeru Ueno, Tadashi Iwanaka, Tetsuya Ishimaru, Jun Iwai, Yoshio Zaizen, Hiroyuki Koga, Ryuichi Shimono, Masayuki Kubota, Naruhiko Murase, Taro Ikeda, Akio Kubota, Keigo Nara, Kaori Satoh, Hizuru Amano, Shinya Takazawa, Yujiro Tanaka, Hiroo Uchida, Hiroshi Kawashima, Takahiro Jimbo, Kohji Fukumoto
    Journal of Pediatric Surgery 48 (12) 2383 - 2388 1531-5037 2013/12 [Refereed][Not invited]
     
    Background: Laparoscopically assisted anorectoplasty (LAARP) was expected to achieve better fecal continence than conventional procedures. However, the issue of which approach is better remains controversial. We compared outcomes between the conventional procedure and LAARP in male infants with rectoprostatic urethral fistula. Methods: Institutes belonging to the Japanese Study Group of Anorectal Anomalies (JSGA) were invited to participate. Subjects were male infants with rectoprostatic urethral fistula treated by the conventional approach (abdominoperineal pull-through and PSARP) or LAARP between 2000 and 2006. Medical charts and operative records were reviewed retrospectively. Results: Eighty-one patients (conventional: 36, LAARP: 45) were enrolled from 15 centers. In both groups, the mean Kelly score was 5. The total score of the scoring system was newly developed by the Japanese Study Group of Anorectal Anomalies. Follow-up Project (5-15 points) was 10.7 and 12.1 in the conventional group and the LAARP group, respectively (p = 0.07). The incidence of failed rectoanal anastomosis, mucosal prolapse, and anal stenosis was comparable in both groups. Posterior urethral diverticula were detected on cystourethrograms in 7% and 11% (p = 1.0) and on MRI in 0% and 34% (p = 0.02) of the conventional and the LAARP groups, respectively. Overall, 94% of diverticula were asymptomatic. Conclusions: Fecal continence and complication rates after LAARP were comparable to those observed after the conventional method. Posterior urethral diverticula were detected more frequently after LAARP. © 2013 Elsevier Inc. All rights reserved.
  • Koshinaga T, Ohashi K, Sugitou K, Ikeda T
    Gan to kagaku ryoho. Cancer & chemotherapy 40 (7) 825 - 832 0385-0684 2013/07 [Refereed][Not invited]
     
    The pathogenesis of pediatric malignant tumors is associated with congenital abnormalities. Oncogenes and antioncogenes are identified in some of these cases. Neuroblastoma arises from the adrenal medulla and sympathetic ganglia. Most neuroblastomas produce catecholamine. Urinary vanillylmandelic acid(VMA)and homovanillic acid(HVA), metabolites of catecholamine, are sensitive tumor markers. Risk stratification according to tumor stage and a combination of prognostic factors helps determine the appropriate therapeutic strategy in clinical settings. Nephroblastoma(Wilms tumor)is the most common pediatric renal tumor and is often accompanied by congenital anomalies. Surgical resection of the tumor and the involved kidney is the initial treatment recommendation in the US and Japan. Consecutive chemotherapy and radiotherapy are administered after surgical staging and a definite histopathological diagnosis. Prognosis is relatively good for most nephroblastoma cases with a favorable histology. In addition to nephroblastoma, clear cell sarcoma of the kidney, characterized by a tendency to metastasize to the bone, is a renal tumor with poor prognosis. Rhabdoid tumor of the kidney is another tumor type; however, its pathogenesis is still unknown and it is associated with extremely poor prognosis because of the lack of effective therapeutic measures. Hepatoblastoma is the most common malignant liver tumor. The serum alpha-fetoprotein level is the most effective tumor marker. Complete surgical resection of the involved liver lobe is the definitive approach for cure. Preoperative chemotherapy increases the possibility of complete surgical resection. High-risk patients have a poor prognosis.
  • 小児在宅医療における医療ケア最前線:医療行為別の診療ポイント ストーマケア
    小林 由加子, 大橋 研介, 杉藤 公信, 池田 太郎, 越永 従道
    小児内科 45 (7) 1269 - 1273 2013/07 [Not refereed][Not invited]
  • Takayuki Masuko, Kiminobu Sugito, Hide Kaneda, Takeshi Furuya, Taro Ikeda, Tsugumichi Koshinaga
    Journal of Pediatric Surgery Case Reports 1 (7) 174 - 176 2213-5766 2013/07 [Refereed][Not invited]
     
    Abstract We present the case of a 13-year-old patient who underwent right salpingo-oophorectomy and was diagnosed with stage Ia ovarian mucinous cystadenocarcinoma. Nine years after complete resection, she was diagnosed with metastasis of the previously resected carcinoma. Despite receiving combination chemotherapy, the patient died of the disease. Long-term follow-up of teenage patients with stage Ia ovarian mucinous cystadenocarcinoma is important. © 2013 Elsevier Inc. All rights reserved.
  • Kiminobu Sugito, Hiroyuki Kawashima, Shinsuke Yoshizawa, Shota Uekusa, Reina Hoshi, Takeshi Furuya, Hide Kaneda, Toshifumi Hosoda, Noriyoshi Konuma, Takayuki Masuko, Kensuke Ohashi, Taro Ikeda, Tsugumichi Koshinaga, Ryouichi Tomita, Yui Shinojima, Kyoko Fujiwara, Takao Watanabe, William A. Held, Hiroki Nagase
    JOURNAL OF PEDIATRIC SURGERY 48 (4) 782 - 788 0022-3468 2013/04 [Refereed][Not invited]
     
    Background: The comprehensive methylation analysis of tumor-specific differently methylated regions in malignant melanomas and brain tumors has led to the identification of non-promoter hypermethylation of zygote arrest 1 (ZAR1). To search the non-promoter ZAR1 hypermethylation in neuroblastomas, we analyzed the levels of the methylation and transcript expression of ZAR1. Methods: The MassARRAY (R) EpiTYPER (Sequenom Inc., San Diego, CA, USA) system was optimized to determine the quantitative methylation levels of ZAR1 for 12 neuroblastoma cell lines, 23 neuroblastoma samples and four adrenal samples. ZAR1 expression levels were evaluated through a quantitative, real-time reverse transcription-polymerase chain reaction. The quantitative methylation levels of ZAR1 were subjected to correlation studies with the established markers of progressive disease and outcome. Results: Strikingly, the hypermethylation of ZAR1 regions and ZAR1 expression levels was observed in the neuroblastoma cell lines and neuroblastoma samples, compared to the adrenal samples. Somatic changes in ZAR1 methylation and ZAR1 expression were found in all three neuroblastoma patients. In the ZAR1 regions, poor-outcome tumors that were MYCN-amplified and/or Stage 3 or 4 and/or the age at diagnosis was >= 18 months, and/or showed an unfavorable histology were frequently hypermethylated. Conclusion: Our results indicate that the hypermethylation of ZAR1 regions is extremely frequent in neuroblastomas and correlates with established markers of progressive disease and outcome. (c) 2013 Elsevier Inc. All rights reserved.
  • Kiminobu Sugito, Hiroyuki Kawashima, Shota Uekusa, Shinsuke Yoshizawa, Reina Hoshi, Takeshi Furuya, Hide Kaneda, Toshifumi Hosoda, Takayuki Masuko, Kensuke Ohashi, Taro Ikeda, Tsugumichi Koshinaga, Kyoko Fujiwara, Jun Igarashi, Srimoyee Ghosh, William A. Held, Hiroki Nagase
    PEDIATRIC BLOOD & CANCER 60 (3) 383 - 389 1545-5009 2013/03 [Refereed][Not invited]
     
    Background The identification of tissue-specific differentially methylated regions (tDMRs) is key to our understanding of mammalian development. Research has indicated that tDMRs are aberrantly methylated in cancer and may affect the oncogenic process. Procedure We used the MassARRAY EpiTYPER system to determine the quantitative methylation levels of seven neuroblastomas (NBs) and two control adrenal medullas at 12 conserved tDMRs. A second sample set of 19 NBs was also analyzed. Statistical analysis was carried out to determine the relationship of the quantitative methylation levels to other prognostic factors in these sample sets. Results Screening of 12 tDMRs revealed 2 genomic regions (SLC16A5 and ZNF206) with frequent aberrant methylation patterns in NB. The methylation levels of SLC16A5 and ZNF206 were low compared to the control adrenal medullas. The SLC16A5 methylation level (cut-off point, 13.25%) was associated with age at diagnosis, disease stage, and Shimada classification but not with MYCN amplification. The ZNF206 methylation level (cut-off point, 68.80%) was associated with all of the prognostic factors analyzed. Although the methylation levels at these regions did not reach statistical significance in their association with prognosis in mono-variant analysis, patients with both hypomethylation of SLC16A5 and hypermethylation of ZNF206 had a significantly prolonged event-free survival, when these two variables were analyzed together. Conclusions We demonstrated that two tDMRs frequently displayed altered methylation patterns in the NB genome, suggesting their distinct involvement in NB development/differentiation. The combined analysis of these two regions could serve as a diagnostic biomarker for poor clinical outcome. Pediatr Blood Cancer 2013; 60: 383-389. (C) 2012 Wiley Periodicals, Inc.
  • 女性外科医か育児をしながらキャリアアッフするために必要なことは何か?
    星野真由美, 渡邉揚介, 後藤博志, 星玲奈, 蘇我晶子, 杉藤公信, 池田太郎, 越永従道
    日本小児外科学会誌 49 (7) 1209 - 1216 2013 [Refereed][Not invited]
  • この症状の診断と次の一手】 乳児の仙骨部皮膚陥凹.
    川島弘之, 池田太郎, 越永従道
    小児外科 45 (2) 230 - 232 2013 [Not refereed][Not invited]
  • 院内症例提示
    井上幹也, 越永従道, 大橋研介, 杉藤公信, 池田太郎
    小児外科 45 (3) 336 - 339 2013 [Not refereed][Not invited]
  • 【周産期の画像診断】腎臓,副腎,肝臓,脾臓,膵,腹部腫瘤
    池田太郎, 川島弘之, 大橋研介, 杉藤公信
    周産期医学 43 452 - 457 2013 [Not refereed][Not invited]
  • 小児固形がんの臨床
    越永従道, 大橋研介, 杉藤公信, 池田太郎
    癌と化学療法 27 15 - 18 2013 [Refereed][Not invited]
  • 下部消化管造影ー胎便関連腸閉塞症に対するガストログラフィン注腸ー
    大橋研介, 池田太郎, 井上幹也, 越永従道
    周産期医学 42 (12) 2012/12 [Not refereed][Not invited]
  • 合併症をもった児の栄養管理 経管栄養
    池田太郎, 杉藤公信, 越永従道
    周産期医学 42 (増刊) 566-569  2012/11 [Not refereed][Not invited]
  • 壊死性腸炎後にacquired hypoganglionosisをきたした1例
    大橋研介, 越永従道, 加藤礼保納, 渡邉揚介, 橋本真, 古屋武史, 金田英秀, 南郷容子, 井上幹也, 杉藤公信, 池田太郎
    小児外科 44 (7) 695-698  2012/07 [Not refereed][Not invited]
  • 大橋研介, 池田太郎, 古屋武史, 金田英秀, 南郷容子, 井上幹也, 杉藤公信, 越永従道
    日本小児外科学会雑誌 48 (4) 2012/06 [Refereed][Not invited]
  • 古屋武史, 井上幹也, 南郷容子, 金田英秀, 大橋研介, 杉藤公信, 池田太郎, 越永従道
    日本小児外科学会雑誌 48 (4) 759-765  2012/06 [Refereed][Not invited]
  • Tomita R, Ikeda T, Fujisaki S, Sugito K, Sakurai K, Koshinaga T, Shibata M
    Hepato-gastroenterology 59 (116) 1063 - 1067 0172-6390 2012/06 [Refereed][Not invited]
     
    BACKGROUND/AIMS: To clarify the significance of a transperineal approach of anterior levatorplasty (ALP) and recto-vaginal septum reinforcement in rectocele patients with soiling, we reported the surgical technique and clinical outcomes two years after this operation. METHODOLOGY: Twelve female patients (33-82 years, average 63.3) complaining of defecation disorders (disturbed defecation including excessive straining during defecation, sensation of incomplete defecation and manual assistance of digitation of the vagina) with soiling underwent the following surgical technique: under spinal anesthesia, rectal wall was opened up to the end of the rectal wall weakness. Rectocele in the weak rectal wall was horizontally sutured. Before closing wound ALP was fashioned. RESULTS: In clinical outcomes, excessive straining during defecation, sensation of incomplete evacuation and defecation by manual assistance were statistically significantly reduced postoperatively after a follow-up of 2 years (p<0.01, p<0.01, p<0.0001, p<0.01, respectively). As an early postoperative complication, perineal wound infection was noted in one patient. Late postoperative complications were not noted in any patient. In overall patient satisfaction 2 years after operation, half of the patients were excellent and no patients were poor. CONCLUSIONS: Combined repair of rectocele and ALP by transperineal approach may be a useful procedure for correcting rectocele with soiling. This procedure is also easy and safe.
  • Uekusa S, Sugito K, Kawashima H, Yoshizawa S, Furuya T, Ohashi K, Ikeda T, Koshinaga T, Mugishima H
    Pediatrics international : official journal of the Japan Pediatric Society 54 (3) 428 - 430 1328-8067 2012/06 [Refereed][Not invited]
  • 症例から学ぶ:超低出生体重児にみられる腸重積症
    大橋研介, 越永従道, 池田太郎, 古屋武史, 金田英秀, 南郷容子, 井上幹也, 杉藤公信, 後藤博志
    小児外科 44 (6) 581-585  2012/06 [Not refereed][Not invited]
  • Kiminobu Sugito, Takeshi Furuya, Hide Kaneda, Takayuki Masuko, Kensuke Ohashi, Mikiya Inoue, Taro Ikeda, Tsugumichi Koshinaga, Ryouichi Tomita, Toshiya Maebayashi
    PANCREAS 41 (4) 554 - 559 0885-3177 2012/05 [Refereed][Not invited]
     
    Objectives: The objectives of the present study were to determine nutritional status, pancreatic function, and morphological changes of the pancreatic remnant after pancreatic tumor resection in children. Methods: The nutritional status was evaluated by the patterns of growth. Pancreatic function was evaluated by using a questionnaire, the Bristol stool form chart, the serum levels of fasting blood glucose, and hemoglobin A1c (HbA1c). Morphological changes of the pancreatic remnant were evaluated by computed tomography, magnetic resonance image, or magnetic resonance cholangiopancreatography. Results: The present study consisted of 6 patients with pancreatic tumor (5 solid pseudopapillary tumors of the pancreas and 1 pancreatoblastoma) who underwent the following operations: tumor enucleation (3), distal pancreatectomy with splenectomy (1), and pylorus-preserving pancreatoduodenectomy (PPPD [2]). The serum levels of HbA1c have been gradually elevated in 2 patients with PPPD. A significant decrease in pancreatic parenchymal thickness and dilatation of the main pancreatic duct were observed in 2 patients with PPPD. Conclusion: Endocrine pancreatic insufficiency after PPPD may be explainable by obstructive pancreatitis after operation. Taking together the results of pancreatic endocrine function and morphological changes of pancreatic remnant after PPPD, tumor enucleation should be considered as surgical approach in children with pancreas head tumor whenever possible.
  • 池田太郎, 金田英秀, 古屋武史, 南郷容子, 大橋研介, 井上幹也, 杉藤公信, 越永従道
    日本小児外科学会雑誌 48 (2) 254-258  2012/04 [Refereed][Not invited]
  • Ano-Neorectal Function on Using Manometry on Patients after Ileal J-pouch Anal Anastomosis in Children
    Ryouichi Tomita, Taro Ikeda, Shigeru Fujisaki, Kiminobu Sugito, Kenichi Sakurai, Tsugumichi Koshinaga, Masahiko Shibata
    Jpn. J. Clin. Physiol. 41 (6) 191-195  2012/02 [Refereed][Not invited]
  • 大橋 研介, 越永 従道, 古屋 武史, 金田 英秀, 南郷 容子, 渡辺 揚介, 橋本 真, 井上 幹也, 杉藤 公信, 池田 太郎
    日本小児外科学会雑誌 特定非営利活動法人 日本小児外科学会 48 (7) 1090 - 1090 2012
  • 大橋 研介, 池田 太郎, 平野 隆幸, 石塚 悦昭, 蘇我 晶子, 後藤 俊平, 石岡 茂樹, 川島 弘之, 金田 英秀, 井上 幹也, 杉藤 公信, 越永 従道
    日本小児外科学会雑誌 特定非営利活動法人 日本小児外科学会 48 (7) 1074 - 1074 2012
  • Yoshizawa Shinsuke, Sugito Kiminobu, Soga Akiko, Uekusa Shota, Kaneda Hide, Furuya Takeshi, Ohashi Kensuke, Inoue Mikiya, Ikeda Taro, Koshinaga Tsugumichi
    Journal of the Japanese Society of Pediatric Surgeons 特定非営利活動法人 日本小児外科学会 48 (6) 956 - 960 0288-609X 2012 
    We report a case of hepatoblastoma with Wilson-Mikity syndrome and Beckwith-Wiedemann syndrome (BWS) in an extremely low birth-weight infant. At 8 months of age, she was referred to our hospital due to liver tumor and elevated serum alpha-fetoprotein (AFP) levels upon screening for tumors with BWS. We started chemotherapy (CITA regimen) without an open biopsy, because of unstable conditions due to emphysema and pulmonary hypertension. After two courses of CITA regimen, she received tumor resection. Postoperatively, she received four courses of low CITA regimen. In this case, we carefully observed not only the level of AFP but lectin-reactive AFP (AFP-L3) because the levels of AFP and AFP-L3 showed gradual decreases with transient increases after complete tumor resection. Here we discussed changes of AFP and AFP-L3 levels after tumor resection in hepatoblastomas.
  • 橋本 真, 大橋 研介, 星 玲奈, 渡邉 揚介, 蘇我 晶子, 金田 英秀, 古屋 武史, 南郷 容子, 井上 幹也, 杉藤 公信, 池田 太郎, 越永 従道
    日本小児外科学会雑誌 特定非営利活動法人 日本小児外科学会 48 (1) 142 - 142 2012
  • Kaneda Hide, Sugito Kiminobu, Yoshizawa Shinsuke, Uekusa Shota, Kawashima Hiroyuki, Furuya Takeshi, Ohashi Kensuke, Inoue Mikiya, Ikeda Taro, Koshinaga Tsugumichi
    Journal of the Japanese Society of Pediatric Surgeons 特定非営利活動法人 日本小児外科学会 48 (4) 754 - 758 0288-609X 2012 
    A case of testicular mature teratoma complicated with scrotal hydrocele is reported. A 1-year/10-month-old boy received a simple closure of processus vaginalis after ingan incision in the lower abdomen to remove right scrotal hydrocele. During operation, a solid mass was found in the right scrotum. An open biopsy was performed, and testicular mature teratoma was diagnosed. At 1-year/11-months of age, we performed a right high inguinal orchiectomy.
  • 大橋 研介, 越永 従道, 渡辺 揚介, 橋本 真, 古屋 武史, 金田 英秀, 南郷 容子, 井上 幹也, 杉藤 公信, 池田 太郎
    日本小児外科学会雑誌 特定非営利活動法人 日本小児外科学会 48 (3) 578 - 578 2012
  • 橋本 真, 金田 英秀, 渡邉 揚介, 南郷 容子, 古屋 武史, 大橋 研介, 井上 幹也, 杉藤 公信, 池田 太郎, 越永 従道
    日本小児外科学会雑誌 特定非営利活動法人 日本小児外科学会 48 (3) 570 - 570 2012
  • 植草 省太, 杉藤 公信, 吉澤 信輔, 川島 弘之, 金田 英秀, 古屋 武史, 大橋 研介, 井上 幹也, 池田 太郎, 越永 従道, 陳 基明, 麦島 秀雄
    日本小児外科学会雑誌 特定非営利活動法人 日本小児外科学会 48 (3) 557 - 557 2012
  • 細川 崇, 杉藤 公信, 小沼 憲祥, 石岡 茂樹, 金田 英秀, 細田 利史, 大橋 研介, 池田 太郎, 越永 従道, 松本 太郎, 加野 浩一郎
    日本小児外科学会雑誌 特定非営利活動法人 日本小児外科学会 48 (3) 554 - 554 2012
  • 吉澤 信輔, 杉藤 公信, 星 玲奈, 植草 省太, 大橋 研介, 池田 太郎, 越永 従道, 藤原 恭子, 相馬 正義
    日本小児外科学会雑誌 特定非営利活動法人 日本小児外科学会 48 (3) 543 - 543 2012
  • Masuko Takayuki, Sugito Kiminobu, Ohashi Kensuke, Kaneda Hide, Furuya Takeshi, Hosoda Toshifumi, Ikeda Taro, Koshinaga Tsugumichi
    Journal of the Japanese Society of Pediatric Surgeons 特定非営利活動法人 日本小児外科学会 48 (3) 442 - 442 2012
  • 富田 凉一, 杉藤 公信, 池田 太郎, 越永 従道, 藤崎 滋, 櫻井 健一, 朴 英智, 柴田 昌彦
    日本小児外科学会雑誌 特定非営利活動法人 日本小児外科学会 48 (3) 690 - 690 2012
  • 南郷 容子, 大橋 研介, 橋本 真, 渡邉 揚介, 金田 英秀, 古屋 武史, 井上 幹也, 杉藤 公信, 池田 太郎, 越永 従道, 杉谷 雅彦
    日本小児外科学会雑誌 特定非営利活動法人 日本小児外科学会 48 (3) 690 - 690 2012
  • 金田 英秀, 杉藤 公信, 星 玲奈, 渡邉 揚介, 橋本 真, 蘇我 晶子, 南郷 容子, 古屋 武史, 大橋 研介, 井上 幹也, 池田 太郎, 越永 従道
    日本小児外科学会雑誌 特定非営利活動法人 日本小児外科学会 48 (3) 630 - 630 2012
  • 渡邉 揚介, 大橋 研介, 池田 太郎, 橋本 真, 星 玲奈, 南郷 容子, 金田 英秀, 古屋 武史, 井上 幹也, 杉藤 公信, 越永 従道
    日本小児外科学会雑誌 特定非営利活動法人 日本小児外科学会 48 (3) 641 - 641 2012
  • 古屋 武史, 池田 太郎, 橋本 真, 渡邉 揚介, 南郷 容子, 金田 英秀, 大橋 研介, 井上 幹也, 杉藤 公信, 越永 従道
    日本小児外科学会雑誌 特定非営利活動法人 日本小児外科学会 48 (3) 525 - 525 2012
  • 杉藤 公信, 橋本 真, 星 玲奈, 渡邊 揚介, 金田 英秀, 古屋 武史, 南郷 容子, 細田 利史, 大橋 研介, 井上 幹也, 池田 太郎, 越永 従道
    日本小児外科学会雑誌 特定非営利活動法人 日本小児外科学会 48 (3) 493 - 493 2012
  • 石岡 茂樹, 細川 崇, 小沼 憲祥, 杉藤 公信, 池田 太郎, 金田 英秀, 細田 利史, 古屋 武史, 小宮山 翔吾, 入部 雄司, 越永 従道, 加野 浩一郎, 松本 太郎
    日本小児外科学会雑誌 特定非営利活動法人 日本小児外科学会 48 (3) 504 - 504 2012
  • 池田 太郎, 越永 従道, 杉藤 公信, 井上 幹也, 大橋 研介, 古屋 武史, 金田 英秀, 南郷 容子, 萩原 紀嗣, 富田 涼一
    日本小児外科学会雑誌 特定非営利活動法人 日本小児外科学会 48 (3) 532 - 532 2012
  • Hiroyuki Kawashima, Kiminobu Sugito, Shinsuke Yoshizawa, Shota Uekusa, Takeshi Furuya, Taro Ikeda, Tsugumichi Koshinaga, Yui Shinojima, Ryo Hasegawa, Rajeev Mishra, Jun Igarashi, Makoto Kimura, Xiaofei Wang, Kyoko Fujiwara, Srymoyee Gosh, Hiroki Nagase
    INTERNATIONAL JOURNAL OF ONCOLOGY 40 (1) 31 - 39 1019-6439 2012/01 [Refereed][Not invited]
     
    Differentiation of human neuroblastoma recapitulates neural crest development. In our whole genome DNA methylation screening of tissue-specific differentially methylated regions (T-DMRs) and developmental stage specific differentially methylated regions (DS-DMRs) we reported that the exon 5 CpG island (CpGi) of Zfp206 (human: ZNF206), which was required to maintain embryonic stem cells in a pluripotent state, was one of potent brain and testis-specific T-DMRs in mice. In this study methylation level of the CpG sites at Zfp206-exon 5 CpGi in mouse brain samples at three different developmental stages (15-day-old embryo; E15, new born; NB, 12-week adult; AD) were quantitatively analyzed and it was identified that Zfp206-exon 5 CpGi was the DS-DMRs in mouse brain. In AD brains, ZfP206-exon 5 CpGi was significantly hypomethylated and Zfp206 expression was repressed, compared with E15 and NB brains. Hence, mehtylation level of human 5'-end of CpGi at ZNF206-exon 5, which is homologous CpGi to mice, was analyzed in neuroblastomas. Although all four adrenal samples showed complete methylation at the homologous region, we found the hypomethylation in 7 out of 26 neuroblastomas and a significant association between the hypomethylation and poor prognosis. In neuroblastoma cell lines and specimens, the hypomethylation was also associated with ZNF206 expression. These data indicated that the changes in DNA methylation levels at the Zfp206-exon 5 might be one of the important factors during neuronal development in mice and that the hypomethylation of the homologous region induced ZNF206 expression in humans and was associated with human neuroblastomagenesis. Even though the function of ZNF206 and its expression regulation in neuroblastoma remain elusive. ZNF206 might be a candidate differentiation suppressor and prognosis marker in neuroblastoma.
  • Ryouichi Tomita, Taro Ikeda, Shigeru Fujisaki, Kiminobu Sugito, Kenichi Sakurai, Tsugumichi Koshinaga, Masahiko Shibata
    HEPATO-GASTROENTEROLOGY 59 (113) 112 - 115 0172-6390 2012/01 [Refereed][Not invited]
     
    Background/Aims: The purpose of this study was to clarify the ano-neorectal functions in pediatric patients with soiling at a short period and without soiling at a long period after restorative colectomy and ileal J-pouch anal anastomosis (IPAA) for ulcerative colitis (UC). Methodology: Ten patients after IPAA for UC in childhood were mamometrically studied, aged 10 to 16 years (mean, 13.9 years). Patients after IPAA with ileostomy closure were studied at 6 months (Group A; all patients had soiling) and 3 years after ileostomy closure (Group B; all patients showed continence). Group C served as controls and consisted of 12 subjects (aged 12 to 16 years, mean, 14.8). Results: Maximum anal sphincter pressure at rest and maximum anal sphincter pressure during voluntary contraction were significantly lower in group A than in groups B and C. Minimum neorectal sensory threshold volume in group A was significantly higher than in groups B and C (p<0.01). Maximum neorectal tolerated threshold volumes and neorectal compliances, and positive rates of neorectoanal inhibitory reflex, showed no significant difference among the groups. Conclusions: Patients with soiling at 6 months after IPAA showed anal sphincter dysfunction and neorectal sensory dysfunction. The IPAA may cause damage to the ano-neorectal apparatus during rectal mobilization due to the short rectal cuff and mucosectomy.
  • 細田利史, 飯野正敏, 木村正幸, 福永 徹, 菅本祐司, 成島一夫, 武藤頼彦, 花岡俊春, 後藤俊平, 金田英秀, 池田太郎, 越永従道
    Journal of Nihon University Medical Association 70 (6) 0029-0424 2011/12 [Refereed][Not invited]
  • 細田利史, 飯野正敏, 木村正幸, 福永 徹, 菅本祐司, 成島一夫, 武藤頼彦, 花岡俊春, 後藤俊平, 金田英秀, 池田太郎, 越永従道
    Journal of Nihon University Medical Association 70 (6) 283-286  0029-0424 2011/12 [Refereed][Not invited]
  • 鼠径ヘルニア、臍ヘルニア
    池田太郎, 星野真由美, 杉藤公信
    周産期医学 必修知識 第7版 41 (増刊) 720-722  2011/12 [Not refereed][Not invited]
  • Kiminobu Sugito, Takeshi Furuya, Hide Kaneda, Takayuki Masuko, Kensuke Ohashi, Mikiya Inoue, Taro Ikeda, Tsugumichi Koshinaga, Hiroshi Yagasaki, Hideo Mugishima, Toshiya Maebayashi
    JOURNAL OF PEDIATRIC SURGERY 46 (11) E25 - E28 0022-3468 2011/11 [Refereed][Not invited]
     
    The local control of neuroblastoma is a very important treatment consideration. We describe a patient who received high-dose rate 60Co remote after loading system treatment for local control of recurrent neuroblastoma and discuss the efficacy of high-dose rate 60Co remote after loading system treatment. (C) 2011 Elsevier Inc. All rights reserved.
  • Kiminobu Sugito, Shota Uekusa, Hiroyuki Kawashima, Takeshi Furuya, Kensuke Ohashi, Mikiya Inoue, Taro Ikeda, Tsugumichi Koshinaga, Ryouichi Tomita, Hideo Mugishima, Toshiya Maebayashi
    INTERNATIONAL JOURNAL OF CLINICAL ONCOLOGY 16 (5) 482 - 487 1341-9625 2011/10 [Refereed][Not invited]
     
    Background Focal nodular hyperplasia (FNH) of the liver is a rare benign lesion that may be related to the vascular and hepatic damage induced by completion of tumor therapy and a reaction to localized vascular abnormality. The aim of this study was to analyze the clinical course in pediatric solid tumor patients with FNH. Methods We analyzed thirty-two patients with pediatric solid tumors who received multiagent chemotherapy (15 advanced neuroblastomas, 7 hepatoblastomas, 5 rhabdomyosarcomas, 2 nephroblastomas, 1 rhabdoid tumor of the kidney, 1 clear cell sarcoma of the kidney and 1 pancreatoblastoma). All of them had been previously treated at our hospital, and have been alive for over 3 years without recurrence. Results FNH lesions were discovered in three (9.4%) of 32 patients, and were neuroblastoma (NB) stage 4. All 3 patients received induction chemotherapy and high-dose alkylating agents, and developed grade 3 (National Cancer Institute Common Toxicity Criteria; NCI-CTC) liver dysfunction during completion of tumor therapy without veno-occlusive disease. Two of the 3 patients received the same induction chemotherapy and high doses of alkylating agents with total body irradiation for cytoreductive agents prior to peripheral blood cell transplantation. FNH lesions in both female patients who received estrogen replacement therapy after completion of tumor therapy have expanded and are increasing. Conclusion FNH appears to be a late complication of iatrogenic disease in NB stage 4 patients. The therapeutic agents for NB stage 4 and estrogen replacement therapy should be considered as risk factors for the development of FNH.
  • 前岡瑛里, 池田太郎, 古屋武史, 星玲奈, 橋本真, 渡邉揚介, 蘇我晶子, 南郷容子, 金田英秀, 大橋研介, 井上幹也, 杉藤公信, 越永従道
    日大医学雑誌 70 (4) 217-220  2011/08 [Refereed][Not invited]
  • 直腸尿道瘻が再開通
    大橋研介, 井上幹也, 杉藤公信, 越永従道
    小児外科 43 (7) 776-780  2011/07 [Not refereed][Not invited]
  • Tsugumichi Koshinaga, Mikiya Inoue, Kensuke Ohashi, Kiminobu Sugito, Taro Ikeda, Ryouichi Tomita
    PEDIATRICS INTERNATIONAL 53 (3) 338 - 344 1328-8067 2011/06 [Refereed][Not invited]
     
    Background: Meconium obstruction without cystic fibrosis in low-birthweight neonates is a distinct clinical entity. We aimed to determine what therapeutic strategies work best in very-low-birthweight neonates with meconium obstruction of the small bowel under varied clinical conditions caused by the associated diseases of prematurity. Methods: Medical records of very-low-birthweight neonates with meconium obstruction of the small bowel treated from 1998 to 2008 were retrospectively reviewed. Pre- and postnatal data, treatments, and clinical outcomes were assessed. Results: Nine patients with perinatal complications were identified. Mean gestational age and birthweight were 26.9 weeks and 863 g, respectively. Abdominal distension developed from 1 to 7 days of life. Five patients were initially treated with Gastrografin enema, three of whom had successful outcomes. Two hemodynamically unstable patients failed to respond to Gastrografin treatment; they ultimately died of sepsis. The remaining four without Gastrografin treatment underwent enterostomy to resolve the obstructions with good results. Conclusions: Gastrografin and surgical treatments should be appropriately selected based on the underlying pathologies of meconium obstruction of the small bowel. Therapeutic Gastrografin enema is effective, safe and repeatable; however, it is not recommended for hemodynamically unstable patients. Surgical intervention is reserved for those who develop rapid abdominal distension that risks perforation.
  • 進行神経芽腫における外科局所治療の意義
    杉藤公信, 金田英秀, 古屋武史, 大橋研介, 井上幹也, 越永従道, 前林俊也, 齋藤勉
    小児外科 43 (5) 477-482  2011/05 [Not refereed][Not invited]
  • 迷走神経温存からみた幽門輪温存幽門側胃切除術の病態
    富田凉一, 藤崎滋, 杉藤公信, 櫻井健一, 越永従道, 柴田昌彦
    日本臨床生理学会雑誌 40 (6) 231-234  2011/03 [Refereed][Not invited]
  • Ryouichi Tomita, Seigo Igarashi, Taro Ikeda, Kiminobu Sugito, Kenichi Sakurai, Shgeru Fujisaki, Tsugumichi Koshinaga, Masahiko Shibata
    Hepato-Gastroenterology 58 (110-111) 1519 - 1522 0172-6390 2011 [Refereed][Not invited]
     
    Background/Aims: There are few reports of the segmental colonic transit time (SCTT) in healthy men. To clarify the SCTT for healthy men, the author measured the SCTT of healty men using radiopaque markers (RM). Methodology: The author analyzed the SCTT of 26 healthy men, who were aged from 24 to 60 years and had a mean age of 48.8 years, with RM (20 radiopaque polyvinyl chloride 0-rings). The criteria for participation included a usual stool frequency of between three per week and three per day, no history of gastrointestinal disease, and no use of medications known to affect gastrointestinal motility. Results: The overall gastrointestinal transit time was 36.2±5.1 hours, and the transit time from the mouth to the cecum was 6.8±1.4 hours. The half-dose transit times of the ileocecal valve, hepatic flexure, splenic flexure, descending-sigmoid line, and evacuation were 6.9±1.6, 15.9±1.7, 18.8±1.7, 24.3±4.4 and 36.4±5.3 hours, respectively. The ascending (9.5±2.3 hours) and descending colon (5.5±4.1 hours) had shorter transit times than the sigmoid-rectum section (12.7±3.5 hours) (p< 0.001, p< 0.01, respectively), and the transverse colon (4.2±2.1 hours) had a shorter transit time than the ascending colon (p< 0.05). There were no significant differences in transit time between the descending and transverse colon. Conclusions: Measuring the SCTT using RM may be effective for detecting the SCTT of specific sections of the bowel. This method is simple and can be easily performed at any radiology department. © H.G.E. Update Medical Publishing S.A.
  • 食道アカラシアの診断と治療
    大橋研介, 井上幹也, 杉藤公信, 越永従道
    小児外科 42 (12) 1325-1328  2010/12 [Not refereed][Not invited]
  • 浅井陽, 池田太郎, 南郷容子, 井上幹也, 杉藤公信, 萩原紀嗣, 越永従道, 草深竹志
    日本小児外科学会雑誌 46 (6) 956-961  0288-609X 2010/10 [Refereed][Not invited]
  • Sugito K, Uekusa S, Kawashima H, Masuko T, Furuya T, Konuma N, Ohashi K, Inoue M, Ikeda T, Koshinaga T
    Pediatric transplantation 14 (5) 614 - 617 1397-3142 2010/08 [Refereed][Not invited]
     
    We studied the effect of the combined treatment with FK506, FTY720, and ex vivo graft irradiation. Five groups of SBT animals were studied on days 3, 5, and 7 after operation (untreated, FK506, FTY720, FK506 + FTY720, FK506 + FTY720 + irradiation). Indirect immunoperoxidase staining was performed against CD4 and MAdCAM-1. The numbers of CD4 positive cells in allografts were also analyzed by flow cytometry. The graft survival was prolonged in all of the FK506- and FTY720-treated groups. SBT allografts treated by FK506 and FTY720 demonstrated less infiltration of CD4 positive cells, but the irradiation group did not show any effects on its expression. In FK506- and FTY720-treated groups, MAdCAM-1 expression on the HEVs in PPs was up-regulated, and its expression on the ECVs in the LP was down-regulated compared with other allograft groups. Irradiation did not show any effects on MAdCAM-1 expression on both HEVs in PPs and ECVs in LP. FK506 and FTY720 prevented the infiltration of CD4 positive cells, the down-regulation of MAdCAM-1 expression on HEVs in PPs, and the up-regulation of MAdCAM-1 expression on ECVs in LP during the early phase of SBT.
  • 直腸肛門感覚検査
    杉藤公信, 富田凉一, 越永従道
    小児外科 42 (7) 781-783  2010/07 [Not refereed][Not invited]
  • autoamputated calcified ovarian cyst in an infant
    Kiminobu Sugito, Takeshi Hosokawa, Shouta Uekusa, Manabu Hanada, Hiroyuki Kawashima, Kensuke Ohashi, Mikiya Inoue, Tsugumiti Koshinaga, Takeshi Kusahuka
    The Nihon University Journal of Medicine 51 (5) 119-127  2010/07 [Refereed][Not invited]
  • Sugito K, Kusafuka T, Kawashima H, Uekusa S, Furuya T, Ohashi K, Inoue M, Ikeda T, Koshinaga T, Maebayashi T
    Pediatric hematology and oncology 27 (3) 250 - 256 0888-0018 2010/04 [Refereed][Not invited]
     
    Focal nodular hyperplasia (FNH) of the liver is rare in children, and it is usually diagnosed through a biopsy of the liver or hepatectomy. The authors report a case of a 10-year-old girl with multiple focal nodular hyperplasia lesions of the liver after the completion of tumor therapy for advanced neuroblastoma, and review the usefulness of the combination of power Doppler ultrasonography (US) and superparamagnetic iron oxide (SPIO) enhanced magnetic resonance imaging (MRI) for the diagnosis of FNH without a biopsy of the liver or hepatectomy.
  • Kiminobu Sugito, Takeshi Kusafuka, Mayumi Hoshino, Mikiya Inoue, Taro Ikeda, Noritsugu Hagiwara, Tsugumichi Koshinaga, Hiroyuki Shichino, Motoaki Chin, Hideo Mugishima
    PEDIATRICS INTERNATIONAL 52 (1) E29 - E31 1328-8067 2010/02 [Refereed][Not invited]
  • Kiminobu Sugito, Hiroyuki Kawashima, Shota Uekusa, Mikiya Inoue, Taro Ikeda, Takeshi Kusafuka
    SURGERY TODAY 40 (1) 83 - 87 0941-1291 2010/01 [Refereed][Not invited]
     
    We herein report the case of a 35-month-old female child presenting with mesenchymal hamartoma of the liver (MHL), with t(11;19)(q13;q13.4) originating in the caudate lobe. This case is the eighth known description of a cytogenetic abnormality in mesenchymal hamartoma of the liver. It is similar to the seven cases previously reported, in that one of the breakpoints involves the chromosome band 19q13.3 or 19q13.4, but it is the first report of an abnormality originating in the caudate lobe.
  • 腎腫瘍ー腎芽腫と腎細胞癌
    杉藤公信, 川島弘之, 池田太郎, 越永従道, 草深竹志
    小児外科 41 (10) 1118-1123  2009/10 [Not refereed][Not invited]
  • 直腸肛門奇形のanovestibular fistulaとrectovestibular fistula
    池田太郎, 草深竹志
    小児外科 41 (4) 397-400  2009/04 [Not refereed][Not invited]
  • 池田太郎, 浅井陽, 南郷容子, 星野真由美, 大橋研介, 井上幹也, 杉藤公信萩原紀嗣, 越永従道, 草深竹志
    日本小児外科学会雑誌 44 (7) 959-964  2008/12 [Refereed][Not invited]
  • 仙尾部奇形腫
    久野宗一郎, 山本樹生, 細野茂春, 池田太郎, 草深竹志
    周産期医学 38 (11) 1433-1437  2008/11 [Not refereed][Not invited]
  • 櫻井健一, 榎本克久, 瀬在明, 東風貢, 古市基彦, 池田太郎天野定雄, 井上和人, 前田英明, 松村髙, 越永従道, 大森一光, 南和友, 草深竹志, 塩野元美, 高山忠利, 根岸七雄
    日大医学雑誌 67 (5) 281-286  2008/10 [Refereed][Not invited]
  • . 胎便関連性腸閉塞の診断と治療 外科からみた胎便関連性腸閉塞.
    越永従道, 南郷容子, 星野真由美, 井上幹也, 杉藤公信, 池田太郎, 草深竹志, 藤田英寿, 嶋田優美, 湊通嘉, 岡田知雄
    日本周産期・新生児医学会雑誌 44 943-947  2008/07 [Refereed][Not invited]
  • 慢性便秘症の直腸肛門感覚についての検討
    池田太郎, 草深竹志, 杉藤公信
    小児外科 40 (2) 146-148  2008/02 [Not refereed][Not invited]
  • Sugito K, Kusafuka T, Hoshino M, Inoue M, Ikeda T, Hagiwara N, Koshinaga T
    Journal of clinical ultrasound : JCU 36 (1) 56 - 58 0091-2751 2008/01 [Refereed][Not invited]
     
    Venous malformations of the small intestine are rare in children, and the preoperative diagnosis of a venous malformation in the small bowel can be very difficult. We report the case of a 2-year-old girl with a solitary cavernous venous malformation of the small intestine that caused gastrointestinal bleeding and anemia and review the usefulness of the combination of color Doppler sonography and 99m Tc-RBC scintigraphy for the diagnosis of venous malformation of the small intestine.
  • Sugito K, Inoue M, Ikeda T, Hagiwara N, Koshinaga T, Kusafuka T
    Surgery today 38 (1) 38 - 41 0941-1291 2008 [Refereed][Not invited]
     
    PURPOSE: We performed a semiquantitative analysis of the expression of Mucosal addressin cell adhesion molecule-1 (MAdCAM-1) and gut-associated tissues (GALT) during small bowel graft rejection in the rat to confirm the effect of FTY720 and ex vivo graft irradiation. METHODS: Small bowel transplantations (SBT) were performed from BN rats to LEW rats. Four groups of SBT animals were studied on days 3, 5, and 7 after operations (untreated, FTY720, ex vivo graft irradiation, FTY720+ex vivo graft irradiation). Indirect immunoperoxidase staining was performed against CD4 and MAdCAM-1. The number of CD4-positive cells in the allografts was also analyzed by flow cytometry. RESULTS: The graft survival was prolonged only in the FTY720-treated groups. The SBT allografts treated by FTY720 demonstrated less infiltration, but the ex vivo graft irradiation group did not show any effect on its expression. In the FTY720-treated groups, MAdCAM-1 expression on high endothelial venules (HEVs) in Peyer's patches (PPs) was upregulated and its expression on endothelial cells of vessels in the lamina propria was downregulated in comparison with the allograft group without FTY720. CONCLUSIONS: It is important to prevent the infiltration of CD4-positive cells, the downregulation of MAdCAM-1 expression on HEVs in PPs and the upregulation of MAdCAM-1 expression on endothelial cells of vessels in the lamina propria for the prolongation of graft survival.
  • Sugito K, Kusafuka T, Inoue M, Ikeda T, Hagiwara N, Koshinaga T
    The Turkish journal of pediatrics 50 (1) 94 - 97 0041-4301 2008/01 [Refereed][Not invited]
     
    Duodenal perforation in early infancy is an uncommon condition. We describe a case of duodenal perforation from suspected ulcer. A premature boy was born at the gestational age of 26 weeks with a birth weight of 764 g. The Apgar score at 1 min was 3 and at 5 min had decreased to 2. He was given intermittent mandatory ventilation for one month after the birth. Ninety-eight days after birth, the infant's abdomen became distended. A supine and cross-table lateral radiograph of the abdomen revealed massive pneumoperitoneum. An exploratory laparotomy was performed, which revealed two perforations in the anterior wall of the first portion of the duodenum. The operation procedure was direct closure and intra-abdominal drainage. On the postoperative first day, he had central urorrhagia from hematencephalon. The patient's growth after surgery has been normal, with no recurrence of duodenal ulcer.
  • K. Sugito, M. Inoue, T. Ikeda, N. Hagiwara, T. Koshinaga, T. Kusafuka
    TRANSPLANTATION PROCEEDINGS 39 (10) 3432 - 3435 0041-1345 2007/12 [Refereed][Not invited]
     
    Objective. We investigated the extent of apoptosis in crypt cells and Peyer's patches (PPs) during small bowel allograft rejection in rats to examine the effect of FTY720 and ex vivo graft irradiation during rejection. Materials and Methods. Orthotopic small bowel transplantations (SBT) were performed from Brown Norway (BN) rats to Lewis (LEW) rats. Four groups of SBT animals were studied on days 3, 5, and 7 after operations: untreated allograft, allograft with FTY720, allograft with irradiation, and allograft with FTY720 + irradiation. Cryostat sections were prepared from the grafts, including PPs. An in situ end-labeling (ISEL) technique was used to detect apoptotic cells. Indirect immunoperoxidase staining was also performed using monoclonal antibodies against rat Fas/FasL. Results. The graft survival was prolonged in the FTY720-treated groups. In the FTY720-treated group, the number of ISEL-positive enterocytes was significantly down-regulated on days 3, 5, and 7 compared with the untreated allograft group. The number of ISEL-positive mononuclear cells was also significantly down-regulated compared with the untreated allograft group. The FTY720 the radiation and the FTY720 + irradiation treated groups showed significantly down-regulated numbers of Fas/FasL-positive enterocytes on day 7 compared with the untreated allograft group. Fas/FasL-positive mononuclear cells were also significantly down-regulated in the allograft compared with the untreated allograft group. Conclusions. FTY720 and ex vivo graft irradiation prevented up-regulation of the number of apoptotic enterocytes, lymphocytes, and Fas/FasL-positive lymphocytes, and also prolonged small bowel allograft survival. Combination FTY720 and ex vivo graft irradiation did not affect graft survival and apoptotic cell expression compared with the FTY720 only group. These findings suggest that FTY720 may prevent both rejection-associated and sepsis-induced apoptosis during the late phase of small bowel graft rejection.
  • Kiminobu Sugito, Takeshi Kusafuka, Mayumi Hoshino, Mikiya Inoue, Hiroshi Goto, Taro Ikeda, Noritsugu Hagiwara, Tsugumichi Koshinaga, Masahiro Fukuzawa, Masanori Nakamura, Hiroyuki Shichino, Motoaki Chin, Hideo Mugishima, Tsutomu Saito, Yoshiaki Tanaka
    PEDIATRIC SURGERY INTERNATIONAL 23 (12) 1203 - 1207 0179-0358 2007/12 [Refereed][Not invited]
     
    To evaluate the efficacy of intraoperative radiation therapy (IORT) and the problem of securing the IORT field in advanced pediatric neuroblastoma. Between 1996 and 2005, 12 children received IORT for advanced pediatric neuroblastoma patients. Electron beam energies ranged from 10 to 12 MeV and median dose was 10 Gy (8 - 12 Gy). All of them had surgery with IORT against the primary tumor site and the abdominal aorta surroundings. A gross total resection (GTR) was achieved in 10 patients and subtotal resection (STR) was two patients. All of 12 patients were classified as high risk. Nine patients were alive 17-120 (mean 48 months) after diagnosis. Local tumor control was achieved in 100% of patients, of whom one experienced local recurrence outside the IORT field. At the operation, it was difficult to secure the IORT field because of the angle of the radiation cylinder in three patients. One of the three of these patients experienced local recurrence outside of the IORT field in the upper side of superior mesenteric artery and two of three patients had an external beam radiation after surgery, and there was no local recurrence. One patient had a postoperative ileus, and one patient had transient diarrhea and hydronephrosis. For advanced neuroblastoma patients, IORT produced excellent local control after surgery. However, there is a problem of securing the IORT field. For local control, it is necessary to add an external beam radiation after IORT when it is difficult to secure the IORT field.
  • Taro Ikeda, Tsugumichi Koshinaga, Mikiya Inoue, Hiroshi Goto, Kiminobu Sugitou, Noritsugu Hagiwara
    PEDIATRICS INTERNATIONAL 49 (5) 668 - 671 1328-8067 2007/10 [Refereed][Not invited]
  • Taro Ikeda, Mikiya Inoue, Kiminobu Sugitou, Noritsugu Hagiwara, Tsugumiti Koshinaga, Takeshi Kusafuka
    JOURNAL OF PEDIATRIC SURGERY 42 (6) 1095 - 1097 0022-3468 2007/06 [Refereed][Not invited]
     
    Anal fistula in infants is a common disease. Although many are recovered by conventional treatment, there are some patients who are not repaired easily. We performed the seton method to an anal fistula and report the good result that we obtained. (c) 2007 Elsevier Inc. All rights reserved.
  • まれな新生児外科疾患の治療8.虫垂炎
    池田太郎, 川嶋弘之, 杉藤公信, 越永従道, 草深竹志
    小児外科 39 (3) 281-285  2007/03 [Not refereed][Not invited]
  • 星野真由美, 浅井 陽, 井上幹也, 杉藤公信, 池田太郎, 萩原紀嗣, 越永従道, 草深竹志
    日本小児外科学会誌 43 (1) 23-31  2007/02 [Refereed][Not invited]
  • Ryouichi Tomita, Seigo Igarashi, Taro Ikeda, Tsugumichi Koshinaga, Shigeru Fujisaki, Katsuhisa Tanjoh
    WORLD JOURNAL OF SURGERY 31 (2) 403 - 408 0364-2313 2007/02 [Refereed][Not invited]
     
    Background: To clarify the neurological function with respect to external anal sphincter (EAS) muscles in patients with or without soiling after low anterior resection (LAR) for lower rectal cancer, we examined the terminal motor latency in the pudendal motor nerves (PNTML). Materials and Methods: Thirty-eight patients after LAR for lower rectal cancer were studied electrophysiologically and compared with 30 healthy volunteers as controls (19 men and 11 women, aged 44 to 76 years of age, with a mean age of 65.5 years). Patients after LAR were divided into two groups [18 patients with soiling (12 men and 6 women, aged 51 to 77 years with a mean age of 64.8 years), 20 patients without soiling (13 men and 7 women, aged 47 to 75 years with a mean age of 62.1 years)]. The mean follow-up time from LAR was 67.2 months (range 60-84 months). Bilateral (left-sided and right-sided) PNTML tests were performed on all patients in order to measure the latency of the response in the bilateral EAS muscle following digitally directed transrectal pudendal nerve stimulation. Results: The distance from the anal verge to the level of anastomosis in patients with soiling (mean, 2.2 cm) was significantly shorter than that in patients without soiling (mean, 4.1 cm) (P < 0.05). Conduction delay of the bilateral PNTML in patients with soiling was longer than that in patients without soiling and normal subjects, significantly (P < 0.01, respectively). There was no significant difference between the right-sided and left-sided PNTML. Conclusions: These findings support the hypothesis that soiling after LAR may be partially caused by damage to the bilateral pudendal motor nerves.
  • Taro Ikeda, Tsugumichi Koshinaga, Mikiya Inoue, Hiroshi Goto, Kiminobu Sugitou, Noritsugu Hagiwara
    PEDIATRICS INTERNATIONAL 49 (1) 58 - 63 1328-8067 2007/02 [Refereed][Not invited]
     
    Background:There are only a few reports discussing the characteristics of intussusception developing in school-age children. The characteristics of these cases are discussed, with reference to previous literature. Methods:The present study included eight cases of intussusception in school-age children among 143 intussusception patients treated on an inpatient basis at Nihon University Itabashi Hospital, during the 11 year period from 1993 to 2003. The remaining 135 patients were assigned to the infant group as controls. The clinical characteristics of intussusception in school-age children were compared with those of the condition developing in infants. Results:The eight children of school age with intussusception ranged in age from 8 to 15 years (mean, 11.6 years), and consisted of five boys and three girls. The major symptom was abdominal pain, occurring in 100% (8/8). Bloody stools and vomiting were reported in two patients each (25%) from this group. The triad of abdominal pain, bloody stools and vomiting was recognized in only one child (12.5%) of this group. Two children (25.0%) had a palpable abdominal mass, and one child (12.5%) complained of diarrhea. None of the school-age children with intussusception had any antecedent infection; five, two and one patients had the ileo-colic type, ileo-ileo-colic type and ileo-ileal type of intussusception, respectively. Four underwent enema reduction and four underwent surgical reduction. One of the eight children (12.5%) had underlying organic abnormality; in the remaining children the condition was labeled idiopathic. One child developed recurrences. Conclusions: In school-age children intussusception is generally believed to be commonly secondary to underlying organic abnormality, but in the present study only one of eight school-age children had underlying organic abnormality; in the remaining children, the condition was labeled idiopathic. The major symptom in school-age intussusception was abdominal pain. Therefore this may need to be differentiated from appendicitis in children of school age. It is considered that abdominal ultrasonography (USG) is a simple and useful method for making the diagnosis of intussusception, and that diagnostic USG should be conducted in all school-age children presenting with acute abdominal pain.
  • Ryouichi Tomita, Seigo Igarash, Tarou Ikeda, Shigeru Fujisaki, Tagumichi Koshinaga, Takeshi Kusabuka
    HEPATO-GASTROENTEROLOGY 54 (73) 58 - 62 0172-6390 2007/01 [Refereed][Not invited]
     
    Background/Aims: There are no reports about the relationship between soiling and other defecation states in patients with ulcerative colitis (UC) after ileal J pouch-anal anastomosis (IPAA). To assess the defecation states in patients with or without soiling at 5 years or more after IPAA for UC, we studied clinical findings in such patients. Methodology: Subjects with UC who had undergone IPAA [a 5-cm short cuff, anal canal mucosa including anal transitional zone (AZT) stripped from the level of dentate line (DL)] with ileostomy closure at least 60 to 132 months (mean; 103.6 months) previously, and who had no pre- or postoperative complications were recruited. They were 43 patients (28 men and 15 women aged 15 to 59 years, average 39.2 years) divided into 2 groups; group A n = 28; patients without soiling (18 men and 10 women aged 15 to 49 years, average 37.5 years) and group B n=15; patients with soiling (10 men and 5 women aged 24 to 59 years, average 42.1 years). Postoperative interviews concerning the defecation states (mean daily stool frequency, nocturnal stool frequency, ability to discriminate flatus from feces, feeling of stool remaining, consistence of stools, soiling, incontinence, and urgency) were conducted with patients after IPAA. Results: No cases in group A showed soiling. All cases in group B had some soiling, 6 cases; rare soiling (at diarrhea), 4 cases; occasional soiling (1 time per 2 or 3 days), 4 cases; frequent soiling (patients must use pad due to daily soiling, 2 cases had incontinence). There was a significant difference between groups A and B (P < 0.001). All cases in group A showed less than 6 times per day and all cases of group B showed 7 or more times per day. There-was a significant difference between groups A and B (P < 0.001). High nocturnal stool frequency was significantly more common in patients of group B than group A (P < 0.001). All cases in group A and 12 cases in group B could significantly discriminate flatus from feces (P < 0.05). Feeling of stool remaining was significantly more common in patients of group B than group A (P < 0.001). The stool consistency of group A was significantly harder than that of group B (P < 0.001). No cases in group A reported incontinence. Two cases in group B had incontinence. Urgency in group B was noted more than in group A. Regarding patient satisfaction (Peck's criteria), all cases in group B and no cases in group A reported "excellent". Ten cases in group B were "good". Three cases in group B were "fair". Two cases in group B showed failure. Patient satisfaction of group A was significantly higher than that of group B (P < 0.01). Conclusions: According to these interviews, no importance of preserving the AZT was recognized. The patients without soiling showed better defecation states than patients with soiling. The patients with soiling showed poor defecation status following IPAA.
  • Kiminobu Sugito, Tsugumichi Koshinaga, Mayumi Hoshino, Mikiya Inoue, Hiroshi Goto, Taro Ikeda, Noritsugu Hagiwara
    PEDIATRICS INTERNATIONAL 48 (6) 616 - 621 1328-8067 2006/12 [Refereed][Not invited]
     
    Background: Recovery from esophageal atresia (EA) and tracheoesophageal fistula (TEF) has improved markedly over the years. But postoperative complications, however, have remained. This study evaluates recovery, preoperative, and postoperative status of patients with EA/TEF. Methods: A retrospective study review was undertaken in 24 patients with EA/TEF after primary anastomosis (January 1975 through September 2003). Results: There were no patients who had major cardiac anomalies or trisomy 18. In total, 17 of 24 (70.8%, group A) patients have survived and seven (29.2%, group B) have died. Birthweight and Apgar Scores in group A were significantly higher than in group B. The ratio of GAP (the distance of the location of the blind pouch from the ends of the upper and lower esophagus) to body length in group B was significantly higher than in group A. The birthweight and Apgar Scores in group A were significantly higher than in group B. When the authors compared their sample of cases by means of the Waterston classification, the Montreal classification and the Spitz classification, there were statistically significant differences between the results using the Waterston classification and the results using to the Spitz classification. Conclusions: For the cases of EA surgery that were examined, the authors concluded that bodyweight at birth and the existence of pre-surgery respiratory system complications have a significant effect on post-surgery recovery, and that results appear to indicate the importance of classification using the Waterston classification and Spitz classification as a means of assessing the degree of risk. Results also appeared to indicate that the control of Respiratory Distress Syndrome throughout both the pre-surgery and post-surgery periods is critical.
  • Koshinaga T, Gotoh H, Sugito K, Ikeda T, Hagiwara N, Tomita R
    Acta paediatrica (Oslo, Norway : 1992) 95 (11) 1381 - 1388 0803-5253 2006/11 [Refereed][Not invited]
     
    AIM: To elucidate how spontaneous localized intestinal perforation (SLIP) is related to intestinal morphological features such as dilatation in very-low-birthweight (VLBW) infants. METHODS: The medical records of 13 VLBW infants (<1500 g) undergoing laparotomy between 1983 and 2003 for presumed SLIP were retrospectively reviewed. Clinical findings including maternal, prenatal and perinatal factors were analysed, and the clinical and surgical findings upon laparotomy were compared. RESULTS: Postnatal pathological conditions included patent ductus arteriosus (n=7), sepsis (n=2), respiratory distress syndrome (n=7), intraventricular haemorrhage (n=2), an indwelling catheter via the umbilical vein (n=1) and pneumonia (n=1). Indomethacin was used in seven neonates with patent ductus arteriosus, and dexamethasone preventive therapy was employed in one neonate for bronchopulmonary dysplasia. Operative findings revealed a localized small punched-out perforation in the ileum. Five patients had intestinal dilatation: two with a perforation in the middle of the dilated intestine, and three with a perforation proximal to the region of dilatation. The muscularis propria was absent in the dilated intestine of four patients. CONCLUSION: This study found no significant relationship between perforation and dilatation of the intestine. Perforation may occur in any portion of the ischaemic intestine when circulatory failure becomes severe, and is not necessarily restricted to the dilated intestine. We believe that SLIP and intestinal dilatation may occur on the same basis in low-birthweight infants; however, the disease process may be aetiologically different.
  • 知っておくべき良性疾患に対する外科的処置および手術Ⅳ. 直腸、肛門 3.鎖肛手術
    富田涼一, 越永従道, 池田太郎
    外科 68 (12) 1523-1528  2006/11 [Not refereed][Not invited]
  • K. Sugito, T. Koshinaga, M. Inoue, T. Ikeda, N. Hagiwara, T. Kusafuka, M. Fukuzawa
    TRANSPLANTATION PROCEEDINGS 38 (9) 3058 - 3060 0041-1345 2006/11 [Refereed][Not invited]
     
    Aim. We investigated the extent of apoptosis in crypt cells and Peyer's patches (PPs) during small bowel allograft rejection in rats to examine the effect of FTY720 during rejection. Methods. Orthotopic small bowel transplantations (SBTs) were performed from BN to LEW rats. Isografted animals served as controls. Three groups of SBT animals were studied on days 3, 5, and 7 after operation: isograft, untreated allograft, allograft with FTY720. FTY720 was orally administered by gavage (1 mg/kg/d) to allograft recipients on 7 consecutive days. Cryostat sections were prepared from grafts, including PPs. An in situ end-labeling (ISEL) technique was used to detect apoptotic cells. Indirect immunoperoxidase staining was also performed using monoclonal antibodies against rat Fas/Fas-L. Results. Graft survival was prolonged in the FTY720-treated group. The number of ISEL-positive enterocytes in the allografts increased significantly on days 3, 5, and 7 compared with the isograft group. In the FTY720-treated group, the number of ISEL-positive enterocytes in the allografts was down-regulated significantly on days 3, 5, and 7 compared with untreated allograft group. In the PPs, the number of ISEL-positive mononuclear cells increased significantly in the allografts compared with the isograft group. In the FTY720-treated groups, the number of ISEL-positive mononuclear cells were down-regulated significantly in the allografts compared with the untreated allograft group. The number of Fas/FasL-positive enterocytes were increased significantly in allografts compared with isograft group. In FTY720-treated groups, the number of Fas/FasL-positive enterocytes were down-regulated significantly on day 7 compared with the untreated allograft group. In the PPs, Fas/FasL-positive mononuclear cells also increased significantly on day 7 in the allografts compared with isografts. In the FTY720-treated groups, Fas/FasL-positive mononuclear cells were down-regulated significantly in the allografts compared with the untreated allograft group. Conclusions. The number of apoptotic enterocytes, lymphocytes, and Fas/FasL-positive lymphocytes increased during small bowel graft rejection. FIY720 prevented up-regulation of the number of apoptotic enterocytes, lymphocytes, and Fas/FasL-positive lymphocytes while also prolonging small bowel allograft survival.
  • 腹会陰式肛門形成術(日大術式)の検証と今後の展開
    池田太郎, 越永従道, 草深竹志
    小児外科 38 (8) 952-957  2006/08 [Not refereed][Not invited]
  • Tsugumichi Koshinaga, Kumiko Wakabayashi, Mikiya Inoue, Kiminobu Sugito, Tarou Ikeda, Noritsugu Hagiwara, Ryouichi Tomita
    SURGERY TODAY 36 (8) 686 - 691 0941-1291 2006/08 [Refereed][Not invited]
     
    Purpose. Pancreatitis has been reported long after total choledochal cyst excision. The aim of this study was to determine if the disease process of postoperative pancreatitis differs between a primary and secondary cyst excision in a long-term follow-up. Methods. Among 53 postoperative patients who underwent a total cyst excision and were followed up, 44 patients underwent a primary cyst excision (primary excision group), while 9 patients underwent a secondary cyst excision after a previous cyst-duodenostomy for internal drainage (secondary excision group). The long-term clinical course, including the pancreatographic findings after a total cyst excision, was compared. Results. In the primary excision group, six patients had mild pancreatitis. Endoscopic retrograde pancreatography demonstrated ductal dilatation that was limited to the common channel in two patients, concurrent with the ventral duct in three, and extended the duct of Santorini in three. Conservative treatments were carried out in three patients, and endoscopic irrigation in one patient with protein plugs in the ventral duct. A resection of the choledochal remnant in the pancreas was performed in two patients with choledochal remnant-associated pancreatitis. From the secondary excision group, 5 of the 9 patients had chronic pancreatitis. Endoscopic retrograde pancreatography showed entire pancreatic ductal dilatation. Two of these patients underwent duodenal papilloplasty at the same time as secondary surgery; however, the disease progressively worsened. Conclusion. In patients undergoing a secondary total excision after internal drainage, it is difficult to half the ongoing aggravating process in pancreatitis.
  • Ryouichi Tomita, Tugumichi Koshinaga, Taro Ikeda, Shigeru Fujisaki, Katsuhisa Tanjoh
    WORLD JOURNAL OF SURGERY 30 (8) 1459 - 1467 0364-2313 2006/08 [Refereed][Not invited]
     
    Background: We investigated the relationship between interdigestive migrating motor complex, phase III (IMMC-pIII) and postoperative quality of life (QOL) in pylorus-preserving gastrectomy (PPG) patients. Materials and Methods: A total of 40 patients (26 men and 14 women; average age 59.4 years) 5 to 7.5 years after PPG for early gastric cancer (Billroth I) (average 6 years and 3 months) were divided into two groups according to the occurrence of IMMC-pIII from the duodenum, and their postoperative quality of life (QOL) was compared. Results: As for appetite, "No change compared with before operation" was significantly more frequent in the IMMC-pIII positive group compared with the negative group (P = 0.0002). Food consumption per meal compared with normal; "80% or more" was significantly more frequent in the IMMC-pIII positive group than the negative group (P = 0.0002). Body weight loss during 5 years after surgery; "6 kg or more" was significantly more frequent in the IMMC-pIII negative group than the positive group (P = 0.0002). Early dumping symptoms did not occur in any patients of either group. Reflux esophagitis and nausea; no patients in the IMMC-pIII positive group experienced these symptoms, which was significantly different from the negative group (P = 0.0018). Abdominal pain occurred but was significantly less frequent in the IMMC-pIII positive group than in the negative group (P = 0.0023). Epigastric fullness occurred but was less frequent in the IMMC-pIII positive group compared with the negative group (P < 0.0001). Gastric stasis of the remnant stomach was significantly more frequent in the IMmC-pIII negative group than in the positive group (P < 0.0001). Gholelithiasis was significantly more frequent in the IMMC-pIII negative group than in the positive group (P = 0.0119). Conclusions: These results showed more satisfactory QOL in the IMMC-PIII positive group than in the negative group.
  • こどもの病気FAQ肥厚性幽門狭窄症についてー各種切開法の優劣は?
    池田太郎, 越永従道
    小児外科 38 (3) 2006/03 [Not refereed][Not invited]
  • 嘔吐を主訴に夜間救急外来を受診した腹部腫瘤性疾患の3例
    石川央朗, 金丸浩, 田原悌, 吉野弥生, 似鳥嘉一, 橋本光司, 渕上達夫, 稲毛康司, 高橋滋, 原田研介, 井上幹也, 杉藤公信, 池田太郎, 萩原紀, 越永従道, 陳基明
    練馬医学会誌 12 110-114  2006/03 [Refereed][Not invited]
  • 大学病院におけるクリニカルパスの有用性(
    星野真由美, 池田太郎, 川嶋弘之, 井上幹也, 杉藤公信, 萩原紀嗣, 越永従道, 秋山斐, 鳴海絵里奈, 井下万希子, 岩佐亜紀子, 松尾美奈, 猪優子, 吉田明子
    日大医学雑誌 65 (1) 11-16  2006/02 [Refereed][Not invited]
  • R Tomita, T Ikeda, S Fujisaki, T Koshinaga, K Tanjoh
    WORLD JOURNAL OF SURGERY 30 (2) 205 - 212 0364-2313 2006/02 [Refereed][Not invited]
     
    Vagal nerve-preserving distal gastrectomy reconstructed by interposition of a jejunal J pouch with a jejunal conduit (hereinafter called DGP) is a function-preserving operation for early gastric cancer. However, some patients after DGP have suffered from postprandial stasis in the substitute stomach, and postprandial stasis leads to abdominal symptoms. To clarify the significance of mosapride citrate (MS) for prevention of food stasis in the substitute stomach for patients after DGP, we studied the effects of MS before and after administration of MS. In a total of 18 patients (10 men, 8 women; aged 34 to 70 years, average 63.1 years) during 5 years after DGP for early gastric cancer (Billroth I, D1 + alpha lymph node dissection, curability A), the relationship between their postoperative quality of life (QOL) and emptying function of the substitute stomach (EFS) was compared using a radioisotope method before MS therapy and after MS therapy at an oral dose of 15 mg/day for 3 months. (1) Interview. After MS therapy patients evidently had more appetite and ate more, with a slightly increase in body weight (0.5 similar to 2 kg) compared with patients before MS therapy. Before and after MS therapy no patients had early dumping symptoms, and after MS therapy all patients clearly had fewer symptoms such as reflux esophagitis, nausea, and abdominal pain compared with before MS therapy. After MS therapy they also had significantly decreased abdominal fullness compared with before MS therapy (P = 0.0026). Endoscopically, we found reflux esophagitis in 2 patients from the before MS therapy group but in no patients from the after MS therapy group. All patients in the before MS therapy group showed residual contents in the substitute stomach, and seven patients in the after MS therapy group showed residual contents in the substitute stomach (P < 0.0001). There was a significant difference between before and after MS therapy (P < 0.0001). (2) EFS; The time to 50% residual rate of the before MS therapy group (80.5 +/- 16.2 min) was significantly slower than that of the after MS therapy patients (65.6 +/- 9.4 min) (P = 0.0091). After MS therapy (28.4% +/- 5.2%), the residual rates at 120 minutes were significantly decreased compared with patients before MS therapy (38.2% +/- 5.7%) (P = 0.0372). Patients from the after MS therapy group clearly had improved gastric stasis compared with the before MS therapy group. These results showed more satisfactory QOL in patients after MS therapy. It is possible that MS therapy improves abdominal fullness due to the postprandial stasis in the substitute stomach, contributing to the improvement of QOL of patients after DGP.
  • 超低出生体重児における鼠径ヘルニアの治療
    星野真由美, 井上幹也, 杉藤公信, 池田太郎, 萩原紀嗣, 越永従道
    小児外科 38 (1) 97-102  2006/01 [Refereed][Not invited]
  • K Sugito, T Koshinaga, M Inoue, T Ikeda, N Hagiwara, M Fukuzawa
    TRANSPLANTATION PROCEEDINGS 37 (10) 4472 - 4474 0041-1345 2005/12 [Refereed][Not invited]
     
    Aim. Mucosal addressin cell adhesion molecule-1 (MAdCAM-1) mediates the homing of lymphocytes to gut-associated tissues (GALT). We performed a semiquantitative analysis of MAdCAM-1 expression during small bowel graft rejection in rat treated with FTY720. Methods. Orthotopic small bowel transplantations (SBT) were performed from BN rats to LEW rats. Isografted animals served as controls. Three groups of SBT animals were studied on days 3, 5, 7 after operations (Isograft, untreated allograft, allograft with FTY720). FTY720 was orally administered by gavage (1 mg/kg/d) to allograft models on 7 consecutive days. Cryostat sections were prepared from grafts, including Peyer's patches (PPs). Indirect immunoperoxidase staining was performed using mAbs against MAdCAM-1. The degree of vascular endothelial staining on high endothelial venules (HEV) in the PPs was graded from 1 (low levels) to 5 (high levels), and in the vessels of the lamina propia from 1 (faint), to 2 (low at the base of villi), 3 (low to the middle of villi), 4 (high to the middle of villi), to 5 (high to villi tip). Results. The graft survival was prolonged in the FTY720-treated group. MAdCAM-1 expression on HEVs in PPs was down-regulated during rejection. In contrast its expression on endothelial cells of vessels in the lamina propria was up-regulated during rejection. In the FTY720-treated groups, MAdCAM-1 expression on HEVs in PPs was up-regulated and its expression on endothelial cells of vessels in the lamina propria was down-regulated compared with untreated allograft group. Conclusions. Alteration in MAdCAM-1 expression may be associated with the development of SB graft rejection. The vessels at the base of villi, which are associated with lymphocyte recruitment, may become sites of intestine immune reactivity during the early phase of small bowel allograft rejection. FTY720 was found to prevent the down-regulation of MAdCAM-1 expression on HEVs in PPs and the up-regulation of its expression on endothelial cells of vessels in the lamina propria while also prolonging small bowel allograft survival.
  • T Nagata, Y Takahashi, Y Ishii, S Asai, M Sugahara-Kobayashi, Y Nishida, A Murata, S Yamamori, Y Ogawa, T Nakamura, H Murakami, M Nakamura, H Shichino, M Chin, K Sugito, T Ikeda, T Koshinaga, H Mugishima
    CANCER GENETICS AND CYTOGENETICS 163 (2) 130 - 137 0165-4608 2005/12 [Refereed][Not invited]
     
    Malignant rhabdoid tumor of the kidney (MRTK) is a rare but highly aggressive tumor in children, and knowledge about the molecular signature of this tumor is limited. We report the molecular genetic alterations and gene expression profile of an MRTK tumor that arose in a 4-month-old Japanese girl. Fluorescence in situ hybridization and Southern blot analyses revealed a homozygous deletion of an similar to 0.29-Mb genomic region bordered by the Rgr and DDT genes in these tumor cells. This deleted region encodes SMARCB1, a candidate tumor suppressor gene for MRTK. Using a high-density oligonucleotide DNA array, we found increased expression of 25 genes, including genes involved in the cell cycle (10 genes), DNA replication (3 genes), cell growth (5 genes), and cell proliferation (5 genes), in this MRTK tumor sample, compared with a noncancerous kidney (NK) sample. On the other hand, 64 genes, including 4 genes regulating apoptosis, were found to show decreased expression in this MRTK tumor sample, compared with the NK sample. Among these alterations, we found alterations of expression of some genes, such as IGF2, MDK, TP53, and TNFSF10, in this MRTK tumor, as described previously. The molecular genetic alterations and altered pattern of gene expression found in this case may have contributed to the biological characteristics of the MRTK tumor that arose in our patient. (c) 2005 Elsevier Inc. All rights reserved.
  • T Koshinaga, M Hoshino, M Inoue, H Gotoh, K Sugito, T Ikeda, N Hagiwara, R Tomita
    PEDIATRIC SURGERY INTERNATIONAL 21 (11) 936 - 938 0179-0358 2005/11 [Refereed][Not invited]
     
    We describe here three cases of pancreatitis after congenital choledochal cyst excision. In these three cases, the choledochal remnant in the pancreas head was markedly dilated, probably because of an incomplete resection of the cyst at the primary operation, and an increase in intraluminal pressure of the pancreatic duct caused by a dynamic obstruction by a protein plug or a pancreatic calculus. Complete cyst excision, including the choledochal wall in the pancreas, is therefore strongly recomended.
  • 先天性胆道拡張症術後遺残胆管に対する手術
    杉藤公信, 越永従道, 井上幹也, 後藤博志, 池田太郎, 萩原紀嗣
    小児外科 37 (9) 1089-1093  2005/09 [Refereed][Not invited]
  • K Sugito, T Koshinaga, M Inoue, T Ikeda, N Hagiwara, M Fukuzawa
    SURGERY TODAY 35 (8) 662 - 667 0941-1291 2005/08 [Refereed][Not invited]
     
    Purpose. FTY720 is a novel immunosuppressive agent that is thought to reduce the number of peripheral blood lymphocytes (PBL) by directing them toward secondary lymphoid organs such as the lymph nodes and Peyer's patches. We studied the effects of FTY720 on aly/aly mice that do not have either lymph nodes or Peyer's patches, as well as on splenectomized aly/aly mice. Methods. FTY720 was orally administered by gavage (1 mg/kg) to aly/aly mice as well as to aly/+ mice with and without a splenectomy on 14 consecutive days. The number of lymphocytes was then counted using True Cell beads and flow cytometry. The number of B220-, CD3-, and CD4-positive cells was also determined. In addition, skin grafts from C3H donor mice were performed on these mice. Results. FTY720 was effective in significantly reducing the total lymphocyte count as well as the B220-, CD3-, and CD4-positive subtypes in the peripheral blood of aly/+ mice as well as in aly/aly mice with and without a splenectomy. While we did observe allograft skin graft rejection in both the aly/+ mice as well as the aly/aly mice recipients and splenectomized aly/aly mice, the graft survival was prolonged in all groups. The skin allografts treated by FTY720 thus demonstrated fewer lymphocytic cells and less infiltration of CD4-positive cells. Conclusions. The administration of FTY720 to mice without lymph nodes, Peyer's patches, or spleens still results in peripheral lymphopenia. In all groups, FTY720 was found to prevent the infiltration of CD4-positive cells in skin allografts while also prolonging skin allograft survival. The fate of these lymphocytes, however, is unclear.
  • T Ikeda, R Tomita, T Koshinaga
    JOURNAL OF PEDIATRIC SURGERY 40 (7) 1146 - 1150 0022-3468 2005/07 [Refereed][Not invited]
     
    Background: No previous report has, to our knowledge, been made on anal mucosal electric sensation in postoperative patients with anorectal malformations (ARMs). We studied the anal mucosal electric sensory threshold (AMEST) in comparison with clinical manifestation. Methods: The study included 25 patients with ARMS who underwent anorectoplasty (ARMS group) and 10 subjects (control group). Based on the type of ARMS, patients were divided into 3 subgroups: high type, n = 14; intermediate type, n = 6; low type, n = 5. The AMEST was measured at 3 positions, at the anal skin margin and 1 and 2 cm from the anal skin margin. The AMEST was analyzed compared with the type of ARMS and clinical manifestation. Results: The AMEST clearly increased at the 3 sites in patients with ARMs, especially those with high and intermediate types, compared with control subjects. The sensitivity threshold in the lower anal canal in the low-type subgroup was about the same as that in the control group. An analysis of clinical manifestations showed significantly increased thresholds in the upper and middle anal canal in the group of patients with difficulty in discriminating between gas and defecation and with fecal incontinence (P <.01 and P <.05). Conclusions: The AMEST for the high-type and intermediate-type subgroups in the ARMS group was worse than that in the low-type subgroup and control group. The AMEST in the upper and middle anal canal was important for gas and defecation distinction and fecal maintenance. (c) 2005 Elsevier Inc. All rights reserved.
  • 乳児壊死性脂肪性肝炎軽快後および,multiple tumoral calcinosis自然消退後に発症した肝芽腫の1例
    杉藤公信, 越永従道, 星野真由美, 井上幹也, 後藤博志, 池田太郎, 萩原紀嗣
    日本小児外科学会誌 41 (4) 668-672  2005/06 [Refereed][Not invited]
  • 池田太郎, 越永従道, 細田利史, 井上幹也, 後藤博志, 杉藤公信, 萩原紀嗣, 富田涼一
    日本小児外科学会雑誌 41 (2) 177-182  2005/04 [Refereed][Not invited]
  • R Tomita, K Tanjoh, S Fujisaki, T Ikeda, W Koshinaga
    HEPATO-GASTROENTEROLOGY 52 (62) 464 - 468 0172-6390 2005/03 [Refereed][Not invited]
     
    Background/Aims: The possibility that interleukin-1 beta (IL-1 beta) is a neuromodulator of the non-adrenergic non-cholinergic (NANC) inhibitory nerves which may be mediated by nitric oxide (NO) was recently reported from animal experiments. To clarify the physiological significance of the relationship between IL-1 beta and NO in the normal human-colon, enteric nervous responses to IL-1 beta in the normal colon muscle strips were investigated. Methodology: Normal colon muscle strips derived from patients who underwent colon resection for leftsided colon cancers (14 cases) were used. The subjects consisted of 8 men and 6 women, aged from 44 to 65 years with a mean age of 56.8 years. A mechanographic technique was used to evaluated in vitro-colon muscle responses to IL-1 beta of adrenergic and cholinergic nerves before and after treatment with various autonomic nerve blockers and N-G-nitro-L-arginine (L-NNA). Results: IL-1 beta concentration dependently caused a relaxation reaction before and after the blockade of the adrenergic and cholinergic nerves. The frequency of relaxation responses after blocking the adrenergic and cholinergic nerves was higher than that before blocking, but there was no significant difference between them. Both tetrodotoxin and L-NNA inhibited the relaxation reaction in response to IL-1 beta in the human colon. Conclusions: These findings suggest that IL-1 beta plays an important role in regulating relaxation of the normal human colon via nitregic nerves, and that NO plays a role as a neurotransmitter in the NANC inhibitory nerves.
  • カントレル症候群の診断・治療
    池田太郎, 越永従道
    小児外科 37 (1) 50-52  2005/01 [Not refereed][Not invited]
  • T Nagata, M Nakamura, H Shichino, M Chin, K Sugito, T Ikeda, T Koshinaga, M Fukuzawa, M Inoue, H Mugishima
    CANCER GENETICS AND CYTOGENETICS 156 (1) 8 - 13 0165-4608 2005/01 [Refereed][Not invited]
     
    Two cases of hepatoblastoma with unique karyotypic changes are described. One case was that of a 2-year-old boy with an unbalanced chromosomal translocation involving 4q35 as the sole chromosomal abnormality. The clonal karyotype of this tumor was 46,XY,add(4)(q35)[3]/46,XY[9]. In the other case, that of a 2-year-old boy, karyotypic analyses revealed the clonal karyotype as 57,XY,+del(1)(p22),+2,+5,+6,+7,+8,+del(12)(p12),+18,+19,+20,+22[4]/46,XY[12]. Review of these two cases, together with previous reports, underscored the significance of numerical and/or structural chromosomal abnormalities of 1q, 4q, 2, 8, and 20 in the development of hepatoblastoma. The present results show that imbalance of the terminal region of 4q could be the sole chromosomal abnormality in a hepatoblastoma. We also found that imbalance of chromosomal regions on chromosomes 1 and 12 may contribute to the development of hepatoblastoma. (C) 2005 Elsevier Inc. All rights reserved.
  • R Tomita, S Fujisaki, E Park, T Ikeda, T Koshinaga
    AMERICAN JOURNAL OF SURGERY 189 (1) 63 - 70 0002-9610 2005/01 [Refereed][Not invited]
     
    Background: It is established that substance P (SP) is released by stimulation of nonadrenergic noncholinergic (NANC) excitatory nerves and vasoactive intestinal peptide (VIP) by stimulation of NANC inhibitory nerves. To evaluate the function of peptidergic nerves such as SP and VIP in small-bowel isografts, we examined the enteric nerve responses to SP and VIP in the isografted rat jejunum, using the normal rat jejunum as a control. Methods: Orthotopic entire small bowel transplantation (SBT) with portocaval drainage was performed from Lewis rats to Lewis rats. Grafted tissue specimens were obtained 130 days after SBT (n = 9). As controls, normal segments of the jejunum were obtained from untransplanted Lewis rats (n = 22). A mechanograph was used to evaluate in vitro jejunal responses to electrical field stimulation of the enteric nervous system before and after treatments with various autonomic nerve blockers and neuropeptides (SP and VIP). Results: SP concentration-dependently mediated the contraction reaction of NANC excitatory nerve in the isografted jejunum and to a lesser extent in the normal jejunum. In addition, there were significant diferences in the percentages showing contraction at 1 x 10(-8) and 1 x 10(-6) g/mL SP between the normal and isografted jejunal muscle strips (P < .05, respectively). VIP concentration dependently mediated the relaxation reaction of NANC inhibitory nerve in the normal jejunum and to a lesser extent in the isografted jejunum. In addition, there was a significant difference between the relaxation frequencies of the normal and those of isografted jejunal muscle strips at 1 x 10(-6) g/mL SP (P < .01). Conclusions: Contraction reactions of SP were observed in both the normal and isografted jejunum but were increased in the isografted jejunum. Relaxation reactions of VIP were also observed in both the normal and isografted jejunum but were decreased in the isografted jejunum. The increase of the effects of SP via NANC excitatory nerves and the decrease of the effects of VIP in mediating NANC inhibitory nerves may be largely related to the peristaltic abnormalities seen in the isografted LEW rat jejunum. (C) 2005 Excerpta Medica Inc. All rights reserved.
  • 中枢神経腫瘍を合併したMalignant rhabdoid tumar of the kidney (MRTK)の1例
    小高美奈子, 麦島秀雄, 細野亜古, 七野浩之, 陳基明, 原田研介, 池田太郎, 萩原紀嗣, 越永従道, 福澤正洋
    小児がん 42 (4) 882-887  2005 [Refereed][Not invited]
  • 新卒後臨床研修必須化における小児外科研修ー従来研修プログラムの成績と課題ー
    越永従道, 星野真由美, 井上幹也, 後藤博志, 杉藤公信, 池田太郎, 萩原紀嗣
    小児外科 37 (5) 511-516  2005 [Not refereed][Not invited]
  • 杉藤公信, 越永従道, 星野真由美, 井上幹也, 後藤博志, 池田太郎, 萩原紀嗣
    日本小児外科学会雑誌 40 (7) 910-913  2004/12 [Refereed][Not invited]
  • 杉藤公信, 越永従道, 池田太郎, 萩原紀嗣
    日本臨床外科学会 65 (11) 2918-2921  2004/11 [Refereed][Not invited]
  • 池田太郎
    日本臨床外科学会雑誌 65 (4) 2004/04 [Refereed][Not invited]
  • 日本小児外科学会会誌 40 (2) 2004/04 [Refereed][Not invited]
  • R Tomita, S Fujisaki, E Park, K Kimizuka, T Ikede, T Koshinaga, M Shibata, K Tanjoh
    TRANSPLANTATION PROCEEDINGS 36 (2) 367 - 369 0041-1345 2004/03 [Refereed][Not invited]
     
    Background. Vasoactive intestinal peptide (VIP) is released by stimulation of nonadrenergic noncholinergic (NANC) inhibitory nerves. In order to evaluate the function of VIP in jejunal isografts, we examined the enteric nerve responses in isografted rat jejunum compared with normal jejunum. Methods. Orthotopic entire small bowel transplantation (SBT) with portocaval drainage was performed from Lewis rats to Lewis rats. Grafted tissue specimens were obtained 130 days after SBT (n = 8). As controls, normal segments of the jejunum were obtained from nontransplanted Lewis rats (n = 20). A mechanograph was used to evaluate in vitro jejunal responses to electrical field stimulation (EFS) of the adrenergic and cholinergic nerves before and after treatment with various autonomic nerve blockers and VIP. Results. The isografted jejunum was more strongly innervated by excitatory nerves, especially NANC excitatory nerves, than the normal jejunum (P < .05). VIP mediated relaxation reactions of NANC inhibitory nerves in the normal but to a lesser extent in the isografted jejunum (P < .05). Conclusions. The increased NANC excitatory nerves and the decreased effects of VIP in mediating NANC inhibitory nerves may largely relate to the peristaltic abnormalities seen in the isografted LEW rat jejunum.
  • S Hosono, H Mugishima, Y Nakano, M Murabayashi, M Shimada, M Minato, S Takahashi, K Harada, T Ikeda, M Fukuzawa
    JOURNAL OF PERINATAL MEDICINE 32 (2) 187 - 189 0300-5577 2004 [Refereed][Not invited]
     
    We describe a case of cord blood harvest for autologous transfusion in a neonate weighing 3,992 g with a giant sacrococcygeal teratoma. The umbilical vein was pierced with an 18-gauge needle, and placental blood was withdrawn into two 50-ml syringes filled with 4 ml of citratephosphatedextrose solution. Resection of the sacrococcygeal teratoma was performed on day one. During the operation the infant lost 46 ml of whole blood, more than 15% of the estimated total blood volume, and thus underwent autologous transfusion with 27.8 ml of packed red cells obtained from autologous cord blood. Consequently, she could avoid homologous blood transfusion during the hospital stay. This case highlights the safety of this procedure, with no evidence of consumption coagulopathy, hemolysis or bacterial infection.
  • R Tomita, T Ikeda, S Fujisaki, M Shibata, K Tanjih
    HEPATO-GASTROENTEROLOGY 50 (54) 1959 - 1962 0172-6390 2003/11 [Refereed][Not invited]
     
    Background/Aims: To clarify the significance of upper gut motility for Hirschsprung's disease and its allied disorders in adults, we studied the upper esophagogastroduodenal motility of adult patients with Hirschsprung's disease and its allied disorders such as hypoganglionosis and intestinal neuronal dysplasia. Methodology: Twelve patients (7 men and 5 women, aged between 20 and 55 years with a mean age of 39.6 years) with Hirschsprung's disease (2 cases) or its allied disorders (8 cases of hypoganglionosis and 2 cases of intestinal neuronal dysplasia) were studied. As a control, 15 healthy volunteers (8 men and 7 women aged between 27 and 69 years with a mean age of 49.0 years) were also examined. To obtain the upper gut motility in Hirschsprung's disease, hypoganglionosis, and intestinal neuronal dysplasia, we performed gastrointestinal transit time study, esophageal manometry, and gastroduodenal manometry. Results: On gastrointestinal transit time, barium stagnated in the upper jejunum in 2 cases of hypoganglionosis, in the terminal ileum in one case of hypoganglionosis and intestinal neuronal dysplasia, and in the colon in the remaining patients. In two of the 12 cases of Hirschsprung's disease and its allied disorders such as hypoganglionosis and intestinal neuronal dysplasia, abnormal esophageal motilities, and absence of interdigestive migrating motor complex, phase III from the stomach were observed. These findings suggested that the entire digestive tract might have been affected in these two cases, i.e., these 2 patients had total gut involvement type of hypoganglionosis. Conclusions: Gastrointestinal transit time and upper esophagogastroduodenal manometry should be performed because of the relatively frequent association of upper gut dysmotilities with these disorders.
  • R Tomita, T Ikeda, S Fujisaki, K Tanjoh, K Munakata
    HEPATO-GASTROENTEROLOGY 50 (52) 1050 - 1053 0172-6390 2003/07 [Not refereed][Not invited]
     
    Background/Aims: To accurately diagnose for Hirschsprung's disease and its allied disorders in adults, we studied the histology and clinical future of 12 adult patients with prolonged, refractory constipation with abdominal distension and pain. I Methodology: Based on clinical signs and symptoms noted on admission, all of 114 patients (12 males and 104 females, aged 20-74 years with a mean age 4 56.6 years) were suspected to have refractory chronic constipation. To obtain an accurate diagnosis, we performed rectal biopsy. Tissue samples were frozen and 12-mum sections were stained with hematoxylin-eosin, with acetylcholinesterase by the method of. Karnovsky and Roots, and with NADPH-diaphorase by the modified Scherer-Singler's method. Results: 1) Histological examinations; On the basis histological studies (rectal biopsies), 8 were diagnosed with hypoganglionosis, 2 with Hirschsprung's disease, and 2 with intestinal neuronal dysplasia. It was possible to, diagnose Hirschsprung's disease and intestinal neuronal dysplasia using rectal mucosal biopsies with hematoxylin-eosin and acetylcholinesterase, staining. However, accurate diagnosis of hypoganglionosis could be made only through examination of the myenteric plexus by NADPH-diaphorase staining in full-thickness rectal. specimens. 2) Clinical symptoms; All patients had refractory chronic constipation with abdominal pain and distension. Two patients with Hirschsprung's disease had constipation neonatally, Of the 8 patients with hypoganglionosis, one had constipation neonatally at sucking age, 2 as infants, 2 at school age, and 2 after operation as adults. Two patients with intestinal neuronal dysplasia had constipation while infants. Onset of signs and symptoms before school age was significantly revealed than that found after. operation as adults (P<0.01). Frequency of bowel movements was 1/7-10 days for Hirschsprung's disease, 1/7-14 days for hypoganglionosis, and 1/7-30 days for intestinal neuronal dysplasia. Conclusions: We were able obtain accurate histological diagnosis of patients with Hirschsprung's disease and intestinal neuronal dysplasia by rectal mucosal biopsy with hematoxylin-eosin and acetylcholinesterase staining. Patients with hypoganglionosis obtained accurate histological diagnosis by fall-thickness rectal biopsy with NADPH-diaphorase staining. Onset of symptoms of disease occurred predominantly before school age. In all of the patients, bowel movements occurred less than once per week.
  • R Tomita, T Ikeda, S Fujisaki, K Tanjoh, K Munakata
    HEPATO-GASTROENTEROLOGY 50 (52) 1050 - 1053 0172-6390 2003/07 [Refereed][Not invited]
     
    Background/Aims: To accurately diagnose for Hirschsprung's disease and its allied disorders in adults, we studied the histology and clinical future of 12 adult patients with prolonged, refractory constipation with abdominal distension and pain. I Methodology: Based on clinical signs and symptoms noted on admission, all of 114 patients (12 males and 104 females, aged 20-74 years with a mean age 4 56.6 years) were suspected to have refractory chronic constipation. To obtain an accurate diagnosis, we performed rectal biopsy. Tissue samples were frozen and 12-mum sections were stained with hematoxylin-eosin, with acetylcholinesterase by the method of. Karnovsky and Roots, and with NADPH-diaphorase by the modified Scherer-Singler's method. Results: 1) Histological examinations; On the basis histological studies (rectal biopsies), 8 were diagnosed with hypoganglionosis, 2 with Hirschsprung's disease, and 2 with intestinal neuronal dysplasia. It was possible to, diagnose Hirschsprung's disease and intestinal neuronal dysplasia using rectal mucosal biopsies with hematoxylin-eosin and acetylcholinesterase, staining. However, accurate diagnosis of hypoganglionosis could be made only through examination of the myenteric plexus by NADPH-diaphorase staining in full-thickness rectal. specimens. 2) Clinical symptoms; All patients had refractory chronic constipation with abdominal pain and distension. Two patients with Hirschsprung's disease had constipation neonatally, Of the 8 patients with hypoganglionosis, one had constipation neonatally at sucking age, 2 as infants, 2 at school age, and 2 after operation as adults. Two patients with intestinal neuronal dysplasia had constipation while infants. Onset of signs and symptoms before school age was significantly revealed than that found after. operation as adults (P<0.01). Frequency of bowel movements was 1/7-10 days for Hirschsprung's disease, 1/7-14 days for hypoganglionosis, and 1/7-30 days for intestinal neuronal dysplasia. Conclusions: We were able obtain accurate histological diagnosis of patients with Hirschsprung's disease and intestinal neuronal dysplasia by rectal mucosal biopsy with hematoxylin-eosin and acetylcholinesterase staining. Patients with hypoganglionosis obtained accurate histological diagnosis by fall-thickness rectal biopsy with NADPH-diaphorase staining. Onset of symptoms of disease occurred predominantly before school age. In all of the patients, bowel movements occurred less than once per week.
  • 胆道閉鎖術後、HCV感染を経て肝細胞癌を合併した1例
    小豆畑丈夫, 越永従道, 田中正純, 池田太郎, 荻原紀嗣, 竹川本夫, 野中倫明, 福澤正洋, 杉谷雅彦, 根本則道
    日小外会誌 39 (6) 765-769  2003/06 [Refereed][Not invited]
  • 浣腸および高圧浣腸
    消化器外科 臨時増刊号 へるす出版 26 (6) 2003/05 [Not refereed][Not invited]
  • TOMITA R., FUJISAKI S., IKEDA T., TANJOH K., FUKUZAWA M.
    The Japanese journal of proctology The Japan Society of Coloproctology 56 (3) 103 - 113 0047-1801 2003/03 
    Background/Aims : Some patients with ulcerative colitis (UC) have a high stool frequency with diarrhea. There are some reports that the cause of the high stool frequency with diarrhea may be due to rapid transit through the stomach. Patients and Methods : Gastric emptying times (GET), for a semisolid diet (rice gruel) using a radioisotope method, and for a liquid diet (orange juice) using an acetoaminophen method, were assessed in 5 patients with UC, which were total-colon, active, and severe type (Group A : 4 men and one woman ; ages 29-49 ; average age, 38.6 years). GET for semisolid and liquid diets in group A was compared with those in 14 healthy volunteers (Group B : 10 men and 4 women ; ages 24-46; average age, 35.8 years). Results : GET for the semisolid diet in group A was almost the same pattern seen in group B. GET for the liquid diet in group A was also almost the same pattern seen in group B. Conclusions : These results showed that gastric emptying functions for semisolid and liquid diets may not influence high stool frequency with diarrhea for patients with UC.
  • 日本外科系連合会誌 28 (1) 2003/02 [Refereed][Not invited]
  • Taro Ikeda, Ryouichi Tomita, Masahiro Fukuzawa
    Japanese Journal of Gastroenterological Surgery 36 (6) 451 - 457 0386-9768 2003 [Not refereed][Not invited]
     
    Introduction: No previous reports have, to our knowledge, been made on anal mucosal electric sensation (AMES) in postoperative patients with anorectal malformation. We studied AEMS in comparison with clinical manifestation. Subjects: Subjects were 24 patients with anorectal malformation (ARM group) who underwent anorectoplasty (19 males and 5 females aged 5-48 years mean age: 18.3 years) and 11 in a control group (4 males and 7 females aged 9-52 years mean age: 30.7 years). Based on the type of anorectal malformation, patients were divided into 3 groups: high, 13 intermediate, 6 low, 5. Methods: AMES was measured at 3 positions, at the anal skin margin and 1 cm and 2 cm from the anal skin margin. AEMS was analyzed compared to the type of anorectal malformation and clinical manifestation. Results: AMES clearly increased at the 3 sites in ARM, especially high and intermediate, compared to the control group. The sensitivity threshold in the lower anal canal in low types was about the same as in the control group. An analysis of clinical manifestations showed significantly increased thresholds in the upper and middle anal canal in the group of patients with difficulty in distinguishing between gas and defecation, and with fecal incontinence (p < 0.01 and p < 0.05). Discussion: AMES for high and intermediate types in the ARM group was worse than that in the low types and normal groups. Anal canal mucosal electric sensitivity in the upper and middle anal canal was important for gas and defecation distinction and fecal maintenance.
  • M Fukuzawa, H Sugiura, T Koshinaga, T Ikeda, N Hagiwara, T Sawada
    JOURNAL OF PEDIATRIC SURGERY 37 (12) 1747 - 1750 0022-3468 2002/12 [Refereed][Not invited]
     
    Background/Purpose: Although angiogenic factors may play an important role in the biology of neuroblastoma, which frequently spreads hematogenously, the mechanism remains unclear. The authors studied tumor progression and invasion from the perspective of angiogenesis and sought to understand the features of this type of tumor. Methods: Thirty-one specimens were resected from patients with neuroblastoma and the expression of vascular endothelial growth factor (VEGF), and its receptor (Flk-1) was examined using immunohistochemistry. The authors looked for correlations among the expressions of VEGF and its receptor with various clinicopathologic factors. In addition, they examined the expression and location of VEGF and Flk-1 mRNA in 10 primary neuroblastoma using in situ hybridization. Results: Both in situ hybridization and immunohistochemistry showed the presence of VEGF expression within the neuroblastoma cells. We found VEGF mRNA in neuroblastoma cells but not vascular endothelial cells according to in situ hybridization. Further, Flk-1 mRNA was present both in neuroblastoma cells and vascular endothelial cells. The level of VEGF expression was higher in unfavorable histology, using the criteria of Shimada, than in favorable histology. Conclusion: The authors suggest that paracrine and autocrine systems are involved in the angiogenesis of neuroblastoma, and the expression of VEGF correlates with the prognosis in neuroblastoma. Copyright 2002, Elsevier Science (USA). All rights reserved.
  • R Tomita, K Tanjoh, S Fujisaki, T Ikeda, M Fukuzawa
    HEPATO-GASTROENTEROLOGY 49 (48) 1540 - 1544 0172-6390 2002/11 [Refereed][Not invited]
     
    Background/Aims: The cause of impaired motility in patients with slow transit constipation is unknown. To clarify the physiological significance of cholinergic, adrenergic, non-adrenergic non-cholinergic inhibitory nerves in the colon of patients with slow transit constipation, we investigated the enteric nerve responses on lesional and normal bowel segments derived from patients with slow transit constipation and patients who underwent colon resection for colonic cancers. Methodology: Twenty preparations were taken from the lesional colon of 6 patients with slow transit constipation (2 men and 4 women, aged 23 to 68 years, with a mean age of 44.0 years). Thirty-six preparations were taken from the normal colon of 12 patients with colonic cancer (6 men and 6 women, aged 40 to 60 years, with a mean age of 52.2 years). A mechanographic technique was used to evaluate in vitro muscle responses to acetylcholine, adrenalin, electrical field stimulation of adrenergic and cholinergic nerves before and after treatment with various autonomic nerve blockers. Results: The contraction reaction to acetylcholine in the colon with slow transit constipation was significantly weaker than in the normal colon (P<0.01). The relaxation reaction to adrenalin in the colon with slow transit constipation was stronger than in the normal colon. The colon with slow transit constipation was more strongly innervated by non-adrenergic non-cholinergic inhibitory nerves than the normal colon, significantly (P<0.05). Conclusions: These findings suggest that a decrease of cholinergic nerve and an increase of nonadrenergic non-cholinergic inhibitory nerve play an important role in the impaired motility observed in the colon of patients with slow transit constipation.
  • R Tomita, S Fujisaki, T Ikeda, M Fukuzawa
    DISEASES OF THE COLON & RECTUM 45 (5) 593 - 600 0012-3706 2002/05 [Refereed][Not invited]
     
    PURPOSE: The cause of dysmotility, in patients with slow-transit constipation is unknown. Nitric oxide has recently been shown to be a neurotransmitter in the nonadrenergic, noncholinergic inhibitory nerves of the human gut. To clarify the physiologic significance of nitric oxide in the colon of patients with slow-transit constipation, we investigated the enteric nerve responses in lesional and normal bowel segments derived from patients with slow-transit constipation and patients who underwent colon resection for colonic cancers. METHODS: Twenty-six preparations were taken from colonic lesions in eight patients with slow-transit constipation (2 men; age, 23 to 69 (mean, 44.8) years). Forty-two preparations were taken from the normal colons of 14 patients with colonic cancer (8 men; age, 40 to 66 (mean, 52.4) years). A mechanographic technique was used to evaluate in vitro muscle responses to electric field stimulation before and after treatment with various autonomic nerve blockers, N-G-nitro-L-arginine, and L-arginine. RESULTS: The colons of patients with slow-transit constipation were more strongly innervated by nonadrenergic, noncholinergic inhibitory nerves than were normal colons (P < 0.05). Nitric oxide was found to act on both normal and slow-transit constipation colons. The colons of patients with slow-transit constipation were more strongly innervated by nitric oxide nerves than were normal colons (P < 0.01). Responses to electric field stimulation were the same in each case among the normal colons and were also the same in each case among the slow-transit constipation colons. CONCLUSION: These findings suggest that an increase of nitric oxide mediates nonadrenergic, nonchotinergic inhibitory nerves and plays an important role in the dysmotility observed in the colons of patients with slow-transit constipation.
  • 臍帯血自己血輸血確立に向けての臨床的検討―第1報 新生児外科疾患における臍帯血自己血輸血の適応と有用性
    細野茂春, 中野優子, 村林督夫, 嶋田優美, 湊 通嘉, 岡田知雄, 高橋 滋, 原田研介, 池田太郎, 福澤正洋, 山本樹生, 麦島秀雄
    日本産婦人科・新生児血液学会誌 12 (2) 21-27  2002 [Refereed][Not invited]
  • 3D-Gd造影MR-Angiographyが有用であった巨大後腹膜奇形腫の1手術例
    池田太郎, 福澤正洋, 小沼憲祥, 若林久実子, 井上幹也, 後藤博志, 杉藤公信, 萩原紀嗣, 越永従道, 早坂和正
    日本小児放射線学会雑誌 189 (3) 184-188  2002 [Refereed][Not invited]
  • 直腸肛門奇形術後症例における直腸肛門感覚の検討
    池田太郎, 富田涼一, 福澤正洋
    日本大腸検査学会雑誌 18 (1) 98-102  2001/09 [Not refereed][Not invited]
  • 日本外科系連合学会誌 26 (2) 240-244  2001 [Not refereed][Not invited]
  • 富田凉一
    日本外科系連合学会誌 25 (5) 2000/10 [Refereed][Not invited]
  • 池田太郎, 金子十郎, 臼井亮平, 朴英智, 阿部英雄, 福澤正洋
    日本臨床外科学会雑誌 61 (8) 2170-2173  2000/08 [Refereed][Not invited]
  • 血便・粘血便
    池田太郎, 福澤正洋
    小児看護 23 (9) 1169-1172  2000/08 [Not refereed][Not invited]
  • 日本外科系連合学会誌 25 (1) 93-96  2000 [Refereed][Not invited]
  • 先天性胆道拡張症術後症例におけるHelical CT cholangiographyと MR cholangiographyの検討
    越永従道, 池田太郎, 萩原紀嗣, 野中倫明, 福澤正洋
    小児外科 32 (1) 54-58  2000 [Not refereed][Not invited]
  • 日本外科系連合学会誌 24 (2) 203  1999 [Not refereed][Not invited]
  • 日本臨床外科学会誌 60 (4) 59  1999 [Not refereed][Not invited]

Books etc

  • 低出生体重児の外科
    窪田昭男 (Contributor壊死性腸炎の腸瘻造設法)
    永井書店 2013/05
  • 周産期医学必須知識
    星野真由美, 杉藤公信 (Joint work720-722)
    東京医学社 2011/12
  • 周産期相談318お母さんへの回答マニュアル
    草深竹志 (Joint work530-531,532-534,537-539,540-541,548-549)
    東京医学社 2009/11
  • (消化管疾患)小児のグリセリン浣腸
    松本紘一 (Joint work165)
    研修医必携 薬物療法と禁忌(東京医学社) 2005/04
  • 外科病棟・手術室のリスクマネジメント
    松野正紀, 根岸七雄, 押田茂実 (Joint work)
    中外医学社 2004/01

Conference Activities & Talks

  • 直腸尿道瘻術後に直腸癌を発症した1例  [Not invited]
    池田太郎
    日本小児外科学会総会  2013/05
  • 直腸肛門奇形術後直腸粘膜脱部に直腸癌を発症した1例  [Not invited]
    池田太郎, 橋本真, 朴英智, 杉本周路, 渡邉揚介, 南郷容子, 古屋武史, 金田英秀, 大橋研介, 井上幹也, 杉藤公信, 越永従道
    第37回日本外科系連合学会学術集会  2012/06  日本外科系連合学会
  • ポスターセッション32:直腸肛門  [Not invited]
    第49回日本小児外科学会学術集会  2012/05  日本小児外科学会
  • 当院におけるcarry-over診療の現況  [Not invited]
    大橋研介, 井上幹也, 杉藤公信, 越永従道, 富田凉一
    第49回日本小児外科学会学術集会  2012/05  日本小児外科学会
  • 小児慢性便秘症における直腸肛門機能の検討  [Not invited]
    池田太郎, 杉藤公信, 越永従道, 富田凉一
    第8回 日本消化管学会総会学術集会 ワークショップ8  2012/02  日本消化管学会
  • 第5群 手術統計  [Not invited]
    第509回 日大医学会例会  2012/02  日大医学会
  • 成人期を迎えた高位直腸肛門奇形における術後排便機能の推移  [Not invited]
    越永従道, 杉藤公信, 井上幹也, 大橋研介, 星野真由美, 古屋武史, 金田英秀, 小沼憲祥, 蘇我晶子
    第48回日本小児外科学会学術集会  2011/07  日本小児外科学会
  • 成人期を迎えた高位直腸肛門奇形の術後排便機能の推移と現状の問題点  [Not invited]
    草深竹志, 越永従道, 萩原紀嗣, 杉藤公信, 井上幹也, 大橋研介, 益子貴行, 花田学, 吉澤信輔
    第25回日本小児外科学会秋季シンポジウム  2009/10
  • 下部消化管3  [Not invited]
    第46回日本小児外科学会学術集会  2009/06
  • 小児外科手術統計  [Not invited]
    池田太郎
    第488回 日大医学会例会  2009/01
  • 第488回日大医学例会 第2群  [Not invited]
    第488回日大医学例会  2009/01
  • 当科における低位病型直腸肛門奇形症例の検討  [Not invited]
    池田太郎, 浅井陽, 南郷容子, 益子貴行, 大橋研介, 井上幹也杉藤公信, 萩原紀嗣, 越永従道, 草深竹志
    Pediatric Surgery Joint Meeting  2008/11
  • 発生異常と考えられる稀な腹腔内嚢胞の1例  [Not invited]
    池田太郎, 南郷容子, 杉藤公信, 越永従道, 草深竹志
    日本周産期・新生児学会総会  2008/07
  • 最近20年間の当科における臍帯ヘルニアの検討  [Not invited]
    池田太郎, 浅井陽, 南郷容子, 益子貴行, 星野真由美, 井上幹也, 杉藤公信, 萩原紀嗣, 越永従道, 草深竹志
    日本小児外科学会総会  2008/05
  • 小児外科手術統計  [Not invited]
    池田 太郎
    第481回日大例会  2008/01
  • 乳児痔瘻におけるseton法の検討  [Not invited]
    池田太郎, 浅井陽, 星野真由美, 井上幹也, 杉藤公信, 萩原紀嗣, 越永従道, 草深竹志
    第44回 日本小児外科学会学術集会  2007/06
  • Childhood Abdominal Cystic Lymphangioma  [Not invited]
    Taro Ikeda, Takeshi Kusafuka, Mikiya Inoue, Kiminobu Sugito, Noritsugu Hagiwara, Tsugumichi Koshinaga
    The 40th Annual Scientific Meeting of the Pacific Association of Pediatric Surgeons together with The Annual Scientific Meeting of the Australasian Association of Pediatric Surgeons  2007/04
  • 小児腹部リンパ管腫の検討  [Not invited]
    池田太郎, 浅井陽, 星野真由美, 井上幹也, 杉藤公信, 萩原紀嗣, 越永従道, 草深竹志
    第107回 日本外科学会総会  2007/04
  • 慢性便秘症における直腸肛門感覚の検討  [Not invited]
    池田太郎, 井上幹也, 杉藤公信, 萩原紀嗣, 越永従道, 草深竹志
    第37回日本小児消化管機能研究会  2007/02
  • 乳児痔瘻におけるseton法の検討  [Not invited]
    池田太郎, 富田涼一
    第61回日本大腸肛門病学会総会  2006/09
  • 新生児虫垂炎の1例  [Not invited]
    星野真由美, 杉藤公信, 越永従道, 草深竹志
    第42回 日本周産期・新生児医学会総会  2006/07
  • 新生児における外科疾患  [Not invited]
    第3回日本大学板橋病院周産期研究会  2006/06
  • 小児便秘症における直腸肛門感覚の検討  [Not invited]
    池田太郎, 星野真由美, 井上幹也, 杉藤公信, 萩原紀嗣, 越永従道, 草深竹志
    第43回日本小児外科学会総会  2006/06
  • 第467回日大医学会例会(小児外科セッション)  [Not invited]
    第467回日大例会  2006/01
  • Completely covered cloacal exstrophyの1例  [Not invited]
    池田太郎, 越永従道, 小沼憲祥, 井上幹也, 杉藤公信, 萩原紀嗣
    第62回 直腸肛門奇形研究会  2005/11
  • 学童期における腸重積症の検討  [Not invited]
    池田太郎, 越永従道, 萩原紀嗣, 杉藤公信, 井上幹也, 星野真由美, 細田利史
    第42回 日本小児外科学会総会  2005/06
  • 右鼠径ヘルニアで発症した新生児虫垂炎の1例  [Not invited]
    池田太郎, 越永従道, 萩原紀嗣, 杉藤公信, 井上幹也, 星野真由美, 細田利史
    第42回日本小児外科学会総会  2005/06
  • 右鼠径ヘルニア嵌頓の診断で手術を行った新生児虫垂炎の1例  [Not invited]
    池田太郎, 越永従道, 萩原紀嗣, 杉藤公信, 井上幹也, 星野真由美, 細田利史
    第30回 日本外科系連合学会学術集会  2005/06
  • 当院における小児外科疾患に対するクリニカルパス導入の試み  [Not invited]
    池田太郎, 越永従道, 星野真由美, 井上幹也, 後藤博志, 杉藤公信, 萩原紀嗣
    第18回 日本小児救急医学会  2004/06
  • 肥厚性幽門狭窄症における到達法の違いによる術式の検討  [Not invited]
    池田太郎, 越永従道, 星野真由美, 井上幹也, 後藤博志, 杉藤公信, 萩原紀嗣
    第41回 日本小児外科学会総会  2004/06
  • 遅発性先天性横隔膜ヘルニア  [Not invited]
    池田太郎, 福澤正洋, 越永従道, 萩原紀嗣, 杉藤公信, 後藤博志, 星野真由美
    第65回 日本臨床外科学会  2003/11
  • 成人期に至った高位・中間位病型直腸肛門奇形術後症例における直腸肛門感覚の検討  [Not invited]
    池田太郎, 福澤正洋, 富田涼一, 越永従道, 杉藤公信, 後藤博志, 井上幹也
    第103回 日本外科学会総会  2003/06
  • 直腸肛門奇形術後症例における外肛門括約筋電気活動と直腸肛門内圧の検討  [Not invited]
    池田太郎, 福澤正洋, 富田涼一, 越永従道, 杉藤公信, 後藤博志, 井上幹也
    第40回 日本小児外科学会総会  2003/06
  • Upper Gut Motility of Hirschsprung’s Disease and Its Allied Disorders in Adults.  [Not invited]
    T. Ikeda, R. Tomita, K. Tanjyoh
    18th World Congress of Digestive Surgery (Hong Kong)  2002/12
  • 出生前診断された仙尾部奇形腫に対する周術期における集学的管理・治療の経験  [Not invited]
    池田太郎, 越永従道, 井上幹也, 後藤博志, 萩原紀嗣, 福澤正洋, 山本樹生, 湊 通嘉, 加藤 実
    第38回 日本新生児学会  2002/07
  • 出生前診断された仙尾部奇形腫に対する周術期における集学的管理・治療の経験  [Not invited]
    池田太郎, 越永従道, 井上幹也, 後藤博志, 萩原紀嗣, 福澤正洋, 山本樹生, 湊 通嘉, 加藤 実
    第39回 日本小児外科学会総会  2002/06
  • 直腸肛門奇形術後症例における直腸肛門感覚の検討  [Not invited]
    池田太郎, 富田凉一, 井上幹也, 後藤博志, 萩原紀嗣, 越永従道, 福澤正洋
    第32回日本小児消化管機能研究会(鹿児島)  2002/02
  • Hirschsprung’s Disease and Its Allied Disorders in Adults: Clinical Studies.  [Not invited]
    T. Ikeda, R. Tomita, K. Tanjyoh
    18th World Congress of Digestive Surgery (Hong Kong)  2002
  • 直腸肛門奇形術後症例におけるS2-4脊髄神経伝導時間の検討  [Not invited]
    池田太郎, 越永従道, 萩原紀嗣, 杉藤公信, 井上幹也, 後藤博志, 遠藤和伸, 福澤正洋, 富田涼一
    第26回 日本外科系連合学会学術集会  2001/06
  • 直腸肛門奇形術後症例における直腸肛門感覚の検討  [Not invited]
    池田太郎, 越永従道, 萩原紀嗣, 杉藤公信, 井上幹也, 後藤博志, 遠藤和伸, 福澤正洋, 富田涼一, 朴英智, 五十嵐誠悟
    第38回 日本小児外科学会総会  2001/06
  • 3D-Gd造影MR-Angiographyが有用であった巨大後腹膜奇形腫の1手術例  [Not invited]
    池田太郎, 越永従道, 萩原紀嗣, 杉藤公信, 後藤博志, 田中正純, 福澤正洋
    第37回 日本小児放射線学会  2001/06
  • Pathophysiologic assessments in S2-4 sacral motor nerves for patient with rectocele.  [Not invited]
    T. Ikeda, R. Tomita, K. Tanjyoh, S. Fujisaki, M. Fukuzawa
    39回 International Surgical Week (Brussels  2001
  • Electrophysiologic assessments in S2-4 sacral motor nerves after ileal J-pouch anal anastomosis for patients with ulcerative colitis and adenomatosis coli in childhood.  [Not invited]
    T. Ikeda, R. Tomita, K. Tanjyoh, S. Fujisaki, M. Fukuzawa
    International Surgical Week (Brussels)  2001
  • 肛門管粘膜電流感覚閾値からみた直腸肛門奇形術後症例の検討  [Not invited]
    池田太郎, 福澤正洋, 富田涼一, 越永従道, 阿蘇大輔, 萩原紀嗣, 五十嵐誠悟野中倫明
    第55回 日本大腸肛門病学会総会  2000/11
  • 直腸肛門奇形術後症例における直腸肛門感覚の検討  [Not invited]
    池田太郎, 福澤正洋, 富田涼一, 越永従道, 萩原紀嗣, 五十嵐誠悟
    日本大腸検査学会総会  2000/11
  • 直腸肛門奇形術後症例における肛門管粘膜電流感覚閾値の検討  [Not invited]
    池田太郎, 福澤正洋, 富田涼一, 越永従道, 阿蘇大輔, 萩原紀嗣, 五十嵐誠悟野中倫明
    第55回 日本消化器外科学会  2000/07
  • 直腸肛門奇形術後症例における陰部・S2-4脊髄神経伝導時間からみた検討  [Not invited]
    池田太郎, 福澤正洋, 富田涼一, 越永従道, 阿蘇大輔, 萩原紀嗣, 五十嵐誠悟野中倫明
    第37回 日本小児外科学会総会  2000/05
  • 学童期に発症した門脈肺高血圧症の1例  [Not invited]
    池田太郎, 福澤正洋, 越永従道, 阿蘇大輔, 萩原紀嗣, 野中倫明
    第13回 日本小児脾臓研究会  2000/02
  • 急性腸炎に回腸穿孔を併発した幼児の1例  [Not invited]
    池田太郎, 越永従道, 萩原紀嗣, 野中倫明, 竹川本夫, 福澤正洋, 富田涼一
    第61回 日本臨床外科学会総会  1999/11
  • 3D-Gd造影MR-Angiographyが有用であった巨大後腹膜奇形腫の1手術例  [Not invited]
    池田太郎, 福澤正洋, 小豆畑丈夫, 萩原紀嗣, 竹川本夫, 野中倫明, 越永従道
    第34回 日本小児外科学会 関東甲信越地方会  1999/11
  • 肺高血圧症を合併した特発性門脈圧亢進症の1例  [Not invited]
    池田太郎, 越永従道, 萩原紀嗣, 福澤正洋, 竹川本夫, 野中倫明, 能登信孝, 原田研介
    第26回 日本小児内視鏡研究会  1999/07
  • 術後に肛門管弛緩不全と直腸瘤を伴った直腸肛門奇形の1例  [Not invited]
    池田太郎, 越永従道, 萩原紀嗣, 福澤正洋, 富田涼一, 五十嵐誠悟, 野中倫明, 竹川本夫
    第24回 日本外科系連合学会学術集会  1999/06
  • 急性腸炎に小腸穿孔併発した1幼児例  [Not invited]
    池田太郎, 福澤正洋, 杉浦宏朗, 萩原紀嗣, 竹川本夫, 野中倫明, 越永従道
    第33回 日本小児外科学会 関東甲信越地方会  1998/11
  • 総胆管壁内嚢胞の1例  [Not invited]
    池田太郎, 福澤正洋, 金子十郎, 団茂樹, 臼井亮平
    第60回 日本臨床外科学会総会  1998/11
  • 大腸脂肪腫の5例  [Not invited]
    池田太郎, 西田茂, 朴英智, 森健一郎, 久保井洋一, 安室省吾
    第66回 日本消化器内視鏡学会 関東地方会  1998/06
  • 大腸脂肪腫の5例  [Not invited]
    池田太郎, 西田茂, 朴英智, 森健一郎, 久保井洋一
    第411回 日大例会  1998/01
  • 胆石術後胆管狭窄の2例  [Not invited]
    池田太郎, 仁木基裕, 杉藤公信, 上田仁
    第12回 肝胆膵研究会  1997/03
  • 下部直腸癌に対する局所切除術の検討  [Not invited]
    池田太郎, 仁木基裕, 杉藤公信, 上田仁
    第404回 日大例会  1997/01
  • 男性乳癌の2症例  [Not invited]
    池田太郎, 阿部英雄, 朴英智, 上田仁, 仁木基裕
    第763回 外科集談会  1996/12
  • 総胆管壁内嚢胞の1例  [Not invited]
    池田太郎, 黒須康彦, 金子十郎, 団茂樹, 臼井亮平
    第397回 日大例会  1996/01
  • 転移性肺平滑筋腫の1例  [Not invited]
    池田太郎, 岡村治明, 渡辺寿和, 勝田勉, 高本雄幸, 榊原雅博, 堀井有尚, 鈴木修一郎
    第759回 外科集談会  1995/11
  • 高齢者虫垂炎症例の検討  [Not invited]
    池田太郎, 岡村治明, 勝田勉, 栗藤克己, 大久保学, 西尾知, 黒須康彦
    第57回 日本臨床外科学会総会  1995/11
  • 成人CIIPSの1例  [Not invited]
    池田太郎, 岡村治明
    東部消化器外科研究会  1995/06
  • 転移性肺平滑筋腫の1例  [Not invited]
    池田太郎, 岡村治明, 渡辺寿和, 勝田勉, 高本雄幸, 榊原雅博, 堀井有尚, 鈴木修一郎, 大畑正昭
    第13回 埼玉県外科集談会  1995
  • 診断に苦慮した若年者腸結核症の一例  [Not invited]
    池田太郎, 黒須康彦, 堀越衛
    外科集談会  1994
  • 虫垂癌の一例  [Not invited]
    池田太郎, 宇賀神若人, 黒須康彦
    外科集談会  1993

MISC



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