Researchers Database

gomi akira

    DepartmentofPediatricNeurosurgery Professor
Last Updated :2021/11/23

Researcher Information

Degree

  • (BLANK)(Jichi Medical University)

J-Global ID

Research Interests

  • pediatric neurosurgery   分子生物学   脳神経外科学   Molecular Biology   Neurosurgery   

Research Areas

  • Life sciences / Neurosurgery
  • Life sciences / Molecular biology

Education

  •        - 1995  Jichi Medical University  医学研究科  脳神経外科学
  •        - 1995  Jichi Medical University  Graduate School, Division of Medicine
  •        - 1984  Jichi Medical University  医学部  医学科
  •        - 1984  Jichi Medical University  Faculty of Medicine

Association Memberships

  • 日本神経内視鏡学会   日本小児血液がん学会   日本小児脳神経外科学会   日本脳腫瘍学会   日本脳腫瘍病理学会   日本癌学会   日本脳神経外科学会   

Published Papers

  • Yoko T. Katsuragi, Akira Gomi, Ataru Sunaga, Kunio Miyazaki, Hideaki Kamochi, Fumihiro Arai, Noriyoshi Fukushima, Yasushi Sugawara
    JOURNAL OF NEUROSURGERY-PEDIATRICS 12 (6) 622 - 625 1933-0707 2013/12 [Refereed][Not invited]
     
    Numerous reports have demonstrated the usefulness of bioresorbable materials, but few have described severe complications caused by delayed degradation. The authors present the case of an intracranial foreign body granuloma caused by plates made of unsintered hydroxyapatite (uHA) particles and poly-L-lactide (PLLA; Super Fixsorb MX, Takiron) after cranioplasty. This 1-month-old boy presented to the authors' department with Pfeiffer syndrome. He had multiple-suture synostosis causing turribrachycephaly, Chiari malformation Type 1, and obstructive sleep apnea syndrome. At 6 months old, the child was treated with multidirectional cranial distraction osteogenesis. The uHA-PLLA plates were applied as base stones to reinforce the pins. After 16 days of distraction and 3 weeks of consolidation, the pins were removed. Seventeen months postoperatively, the plate on the right temporal bone showed passive intraosseous translocation (PIT), and by 2 years postoperatively, the plate was completely left behind in the cerebrum. At 3.5 years postoperatively, MRI disclosed a contrast-enhanced mass with surrounding brain edema at the site of the plate. The lesion was resected. The clinical history and histological specimens led to a diagnosis of foreign body granuloma surrounding the nonabsorbed resorbable plate in the dura mater. Resorbable plates are clearly useful resources in cases in which delayed absorption will not prove problematic, but careful application and follow-up is required when dealing with the growing skull given the possibility of intracranial displacement after PIT.
  • Satsuki Miyata, Masashi Urabe, Akira Gomi, Mutsumi Nagai, Takashi Yamaguchi, Tomonori Tsukahara, Hiroaki Mizukami, Akihiro Kume, Keiya Ozawa, Eiju Watanabe
    NEUROLOGIA MEDICO-CHIRURGICA 53 (10) 645 - 654 0470-8105 2013/10 [Refereed][Not invited]
     
    Cytosolic isocitrate dehydrogenase 1 (IDH1) with an R132H mutation in brain tumors loses its enzymatic activity for catalyzing isocitrate to alpha-ketoglutarate (alpha-KG) and acquires new activity whereby it converts alpha-KG to 2-hydroxyglutarate. The IDH1 mutation induces down-regulation of tricarboxylic acid cycle intermediates and up-regulation of lipid metabolism. Sterol regulatory element-binding proteins (SREBPs) regulate not only the synthesis of cholesterol and fatty acids but also acyclin-dependent kinase inhibitor p21 that halts the cell cycle at G1. Here we show that SREBPs were up-regulated in U87 human glioblastoma cells transfected with an IDH1(R132H)-expression plasmid. Small interfering ribonucleic acid (siRNA) for SREBP1 specifically decreased p21 messenger RNA (mRNA) levels independent of the p53 pathway. In IDH1(R132H)-expressing U87 cells, phosphorylation of Retinoblastoma (Rb) protein also decreased. We propose that metabolic changes induced by the IDH1 mutation enhance p21 expression via SREBP1 and inhibit phosphorylation of Rb, which slows progression of the cell cycle and may be associated with non-aggressive features of gliomas with an IDH1 mutation.
  • Akira Gomi, Hirofumi Oguma, Rieko Furukawa
    CHILDS NERVOUS SYSTEM 29 (9) 1641 - 1645 0256-7040 2013/09 [Refereed][Not invited]
     
    This study aims to ascertain which specific types of sacrococcygeal dimples are associated with underlying spinal cord malformations. From 2008 to 2011, we prospectively examined children less than 2 years old with sacrococcygeal dimples. Each patient underwent clinical assessment of dimples and magnetic resonance imaging. We devised the following new classification of dimples according to their location: type 1, dimples located within the gluteal crease, including coccygeal pits; type 2, dimples located at the upper edge of the gluteal crease with associated curving or deformity of that crease; and type 3, dimples located well above the gluteal crease. We evaluated 142 patients with sacrococcygeal dimples. Although we identified spinal malformations such as spinal lipomas, filum cysts, and thickened fila terminalia in only 17 % of infants with type 1 dimples, we observed them in 45 % with type 2 and 55 % with type 3. Thus, in terms of the rate of spinal malformations, there are significant differences between types 1 and 2 and between types 1 and 3. We propose a new classification of sacrococcygeal dimples. Although type 2 dimples have previously been classified as simple dimples that require no further investigation, we have identified that they are strongly associated with spinal deformities, comparable to atypical type 3 dimples. Thus, both types 2 and 3 dimples warrant radiological investigation.
  • Shigeki Matsubara, Rie Usui, Yasunori Koike, Akira Gomi
    Archives of Gynecology and Obstetrics 3 287 (3) 617 - 618 0932-0067 2013/03 [Refereed][Not invited]
  • TANAKA Satoshi, TASHIRO Takashi, ONOZAKI Satoshi, TAKANASHI Junko, GOMI Akira, UJIIE Hiroshi
    脊髄外科 : 日本脊髄外科研究会機関誌 = Spinal surgery : official journal of the Japanese Society of Spinal Surgery 26 (1) 52 - 59 0914-6024 2012/04 [Not refereed][Not invited]
  • Kimura Y, Seichi A, Gomi A, Kojima M, Inoue H, Kimura A
    Neurologia medico-chirurgica 9 52 (9) 683 - 686 0470-8105 2012 [Refereed][Not invited]
  • Akira Gomi
    Neurological Surgery 39 (3) 295 - 304 0301-2603 2011/03 [Refereed][Not invited]
  • Tanaka S, Tashiro T, Gomi A, Takanashi J, Ujiie H
    Surgical neurology international 2 111  2011 [Refereed][Not invited]
  • Tanaka S, Tashiro T, Gomi A, Ujiie H
    Neurologia medico-chirurgica 9 51 (9) 673 - 677 0470-8105 2011 [Refereed][Not invited]
  • Satsuki Miyata, Akira Gomi, Takashi Yamaguchi, Yuichi Tanaka, Eiju Watanabe, Akira Tanaka
    BRAIN TUMOR PATHOLOGY 27 (1) 45 - 50 1433-7398 2010/04 [Refereed][Not invited]
     
    A case of unclassified, pediatric cerebral neuroepithelial tumor in a 10-year-old girl that showed remarkable radiosensitivity is reported. MRI revealed a brain tumor of mixed intensity with heterogeneous enhancement in the medial temporal lobe, extending to the basal ganglia. The tumor was partially removed. On pathology, the main part of the tumor showed immature features: the tumor cells had a chromatin-rich large nucleus and less cytoplasm, and mitoses and fragmentation of the nuclei were frequent. On immunohistochemistry, the tumor cells were negative for glial fibrillary acidic protein (GFAP) and synaptophysin and positive for Olig2. The maximum MIB-1 index was 70%. The part invading into the surrounding brain showed similarities in form to a highly anaplastic astrocytoma. The infiltrating tumor cells were positive for GFAP and less positive for Olig2. After 40 Gy radiation, the residual tumor was markedly reduced. Neuroepithelial tumors rarely show such high radiosensitivity, and the reason for the radiosensitivity in the present case may have been the immaturity of the tumor cells.
  • Yasushi Sugawara, Hirokazu Uda, Syunji Sarukawa, Ataru Sunaga, Akira Gomi
    Japanese Journal of Neurosurgery 日本脳神経外科コングレス 19 (4) 280 - 285 0917-950X 2010 [Not refereed][Not invited]
     
    Background: The advantages of the distraction procedure for craniosynostosis reported thus far are osteogenesis, absence of initial fixation materials, and simultaneous skin expansion, which enable sufficient bone movement. These advantages provide benefits to the patient including a less invasive procedure, fewer relapses, and more stable results. On the other hand, the disadvantages include a prolonged treatment period and the need for secondary surgical intervention. The most tangible disadvantage is the limitation in morphological correction resulting from the unidirectional internal types of devices. In order to solve these problems that diminish the advantages of the distraction procedure, we have designed a new distraction system, the MCDO system®. Methods: From 2003 to 2007, a selected group of 23 patients with syndromic and nonsyndromic craniosynostosis were treated using the MCDO system. The mean patient age was 27 months (9 to 75 months). Follow-up was 18 to 78 months (median: 58.5 months). Results: The postoperative clinical course was uneventful in all cases. There were no cases of meningitis, liquid fistula, or extradural hematoma during distraction. The mean volume of blood transfused was 18.0 ml/kg (0 to 54.7 m//kg) body weight. There was minor pin-track infection at the site of the anchor pins in 13 patients, which healed with ordinary conservative treatment and shampooing. The planned distraction program was completed in all cases. The mean duration of distraction was 10 days (7 to 13 days), and the consolidation period was 27.5 days (19 to 35 days). The mean duration of frame fitting was 38.5 days (30 to 54 days). Traction pin and anchor pin loosening occurred in 28/204 (13.7%) and 23/130 (17.7%) among all patients. The morphological results in all patients were satisfactory. Slight bony bumps formed between the distracted bone pieces however, they disappeared within 6 months by formation of bone between the gaps. Conclusion: The MCDO system allows the contouring of any kind of skull deformity according to the concept of distraction osteogenesis. The distraction method with the MCDO system offered numerous advantages over not only the distraction method with unidirectional internal devices, but also conventional cranioplasty for patients 9 months of age or older, patients with craniosynostosis, and for patients requiring secondary surgery.
  • SUGAWARA Yasushi, UDA Hirokazu, SARUKAWA Syunji, SUNAGA Ataru, GOMI Akira
    小児の脳神経 34 (4) 336 - 340 0387-8023 2009/08 [Not refereed][Not invited]
  • Sugawara Yasushi
    Japanese journal of neurosurgery 日本脳神経外科コングレス 18 (0) 0917-950X 2009/04 [Not refereed][Not invited]
  • Transient Induction of the MRP/GS-X Pump and γ-Glutamylcysteine Syntherase by 1-(4-Amino-2-methyl-5-pyrimidinyl) methyl-3-(2-chloroethyl)-3-nitrosourea-in Human Glioma Cells
    Cancer Research 57, 5292 1997 [Not refereed][Not invited]
  • Elevated Expression of DNA Polymerase β Gene in Glioma Cell Lines with Acquired Resistance to 1-(4-Amino-2-methyl-5-pyrimidinyl) methyl-3-(2-chloroethyl)-3-nitrosourea
    Biochem Biophys Res Comm 227, 558 1996 [Not refereed][Not invited]
  • Freguent Loss of the cyclin-dependent kinase-4 Inhibitor Gene in Human Gliomas
    Japanese Journal of cancer Research 86(4), 342 1995 [Not refereed][Not invited]
  • Ultrastructural study of Glossopharyngeal Neurinoma
    Journal of Clinical Electorn Microscopy 23(2), 195 1990 [Not refereed][Not invited]

Books etc

MISC

Research Grants & Projects

  • 脳腫瘍の分子生物学
    遺伝子科学研究
    Date (from‐to) : 1988
  • Molecular Biology of Brain Tumors
    Gene Science Research
    Date (from‐to) : 1988


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