Researchers Database

mieda mitsuyo

    JichiMedicalUniversityHealthCareCenter Assistant Professor
Last Updated :2021/12/04

Researcher Information


J-Global ID

Research Interests

  • トランスジェニックマウス   CDX2   siRNA   Sonic Hedgehog   COX2   Math1   miRNA   腸上皮化生   胃癌   

Research Areas

  • Life sciences / Gastroenterology

Academic & Professional Experience

  • 2007  Jichi Medical UniversitySchool of Medicine助教


  • Manabu Nagayama, Norio Isoda, Mitsuaki Sato, Yuji Ino, Ryou Toyoda, Naoyuki Nishimura, Mitsuyo Yoshizawa, Toshiya Ootake, Toshihiko Higashizawa, Hiroshi Kawata, Kouji Koinuma, Yoshikazu Yasuda, Hiroki Harashima, Mitsugu Hironaka, Kentaro Sugano  Acta Hepatologica Japonica  51-  (3)  127  -134  2010  [Not refereed][Not invited]
    The patient was a 53-year-old woman referred to our department for evaluation of a giant intraabdominal cystic lesion in May 2008. Imaging studies revealed a unilocular cystic lesion with multiple mural nodules that was considered to originate from the left lobe of liver. She underwent resection of the left lobe of liver. The cystic tumor, 28 x 24 cm in size, weighed 5.5 kg was removed en block and no lymph node metastasis was observed. Within the cystic wall, multiple papillary nodules composed of mucinous columnar epithelium exhibiting mitosis and nuclear atypism were scattered leading to the diagnosis of biliary cystadenocarcinoma. Neither ovarian-like stroma nor communication between the bile duct and the tumor was evident. Immunohistochemical staining showed that the epithelial cells were diffusely positive for MUC5AC, partially positive for MUC1, and negative for MUC2 and MUC6, indicating gastric foveolar-type mucin was the major mucin phenotype in both cancerous and non-cancerous epithelium of the tumor. © 2010 The Japan Society of Hepatology.
  • YOSHIZAWA Mitsuyo, OSAWA Hiroyuki, YAMAMOTO Hironori, SATOH Kiichi, NAKANO Hidetoshi, TSUKUI Mamiko, SUGANO Kentaro  GASTROENTEROLOGICAL ENDOSCOPY  51-  (8)  1748  -1752  2009/08  [Not refereed][Not invited]
    Background : Magnifying narrow band imaging system is useful for the diagnosis of early gastric cancer. However, it is difficult for the operator of the scope to maintain the correct distance between the tip of the endoscope and the gastric mucosa for appropriate visualization. The newly developed optimal band imaging system can reconstruct good spectral images derived from ordinary endoscopic images and enhance the mucosal surface without magnification as well as with low magnification. This imaging technique is based on narrowing the bandwidth of the conventional image arithmetically, using spectral estimation technology.<BR>Methods : We evaluated endoscopic features of 30 lesions with elevated-type, 32 lesions with depressed-type and two lesions with fiat-type early gastric cancer using this new system.<BR>Results : We found the best images in all cases of early gastric cancers by using a specific combination of the following three wavelengths available in this system : 470 nm for blue, 500 nm for green and 550 nm for red. The optimal band images showed the depressed-type early gastric cancer as reddish lesions distinct from the surrounding yellowish non-cancerous area, leading to a clear demarcation line between the cancerous and non-cancerous mucosa without magnification. Moreover, 30-40-fold magnified optimal band images showed a clearly irregular microvascular pattern or a microstructure pattern of the mucosal surface in all types of gastric cancers.<BR>Conclusion : This new system can provide useful information for diagnosing various types of early gastric cancers without and with low magnification.
  • IWAZU Yoshitaka, TOMIYAMA Takeshi, SEKINE Yutaka, YOSHIZAWA Mituyo, SUGANO Kentaro, KAMISAWA Osamu, YASUDA Yoshikazu  Journal of medical ultrasonics = 超音波医学  29-  (4)  J389  -J397  2002/07  [Not refereed][Not invited]

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