Researchers Database

matsubara yuri

    CenterforCommunityMedicineDepartmentofPublicHealth Research Associate
Last Updated :2021/11/23

Researcher Information

J-Global ID

Research Areas

  • Other / Other

Published Papers

  • Hiroya Masuda, Ryusuke Ae, Taka-Aki Koshimizu, Masami Matsumura, Koki Kosami, Kanako Hayashida, Nobuko Makino, Yuri Matsubara, Teppei Sasahara, Yosikazu Nakamura
    Clinical rheumatology 2021/08 
    INTRODUCTION/OBJECTIVES: Hyponatremia is a potential risk factor for the development of coronary artery lesions (CALs) identified after acute Kawasaki disease (KD). However, the serum sodium distribution corresponding to the reference intervals differs between infants (< 1 year of age) and older children. We hypothesized the association of serum sodium level with CAL complications differs between infants and older patients with KD. METHODS: We analyzed 21,610 population-based patients who developed KD throughout Japan during 2013-2014. We performed multivariable logistic regression analyses to evaluate the association between serum sodium and CAL complications. Additionally, we stratified the serum sodium distribution associated with CAL complications by infants and older patients. RESULTS: CALs were identified in 158 (3.6%) infants and 302 (1.8%) older patients. Infants were more likely to develop CALs when within the normal sodium range compared with older patients (75% vs. 29%), whereas most older patients developed CALs with a sodium level lower than the reference interval. Serum sodium ≤ 130 mEq/L indicated significantly higher risk for development of CALs in both groups (adjusted odds ratio [95% confidence intervals] = 3.21 [1.65-6.25] in infants and 1.74 [1.18-2.57] in older patients). CONCLUSIONS: Serum sodium distribution associated with CAL complications differed greatly between infants and older patients. Older patients developed CALs with sodium levels lower than the reference interval; however, among infants, hyponatremia was not necessarily a risk factor for developing coronary artery lesion. When considering risk assessments for CALs using serum sodium levels, infants with KD should be distinguished from older patients. Key Points • Hyponatremia is a potential risk factor for the development of coronary artery lesions (CALs) among patients with Kawasaki disease. • However, the serum sodium distribution corresponding to the reference intervals differs between infants (< 1 year of age) and older children. • Most infants developed CALs within the normal sodium range, whereas older patients developed at a range lower than the reference interval. • These findings highlight that when considering risk assessments for CALs using serum sodium levels, infants should be distinguished from older patients.
  • Haruki Takikawa, Ryusuke Ae, Yuri Matsubara, Daisuke Matsubara, Nobuko Makino, Koki Kosami, Masanari Kuwabara, Teppei Sasahara, Yosikazu Nakamura
    Archives of disease in childhood 106 (7) 669 - 673 2021/07 
    OBJECTIVE: To investigate whether redness and crusting at the bacille Calmette-Guérin inoculation site (BCGitis), identified during acute illness owing to Kawasaki disease (KD), is an independent risk factor for development of cardiac complications. DESIGN: Retrospective cohort study using data from the nationwide KD survey in Japan. SETTING: Survey respondents included hospitals specialising in paediatrics and hospitals with ≥100 beds and a paediatric department throughout Japan. PATIENTS: We included 17 181 patients with KD across Japan during 2005-2006. MAIN OUTCOME MEASURES: BCGitis and cardiac complications resulting from KD. RESULTS: BCGitis was identified in 7549 (44%) patients with KD. Compared with patients without BCGitis, those with BCGitis were younger, more likely to be male, less likely to have recurrent status and visited a hospital and underwent initial intravenous immunoglobulin (IVIG) treatment earlier after KD onset. In the unadjusted model, patients with BCGitis were significantly less likely to have cardiac complications (crude OR 0.81, 95% CI 0.71 to 0.92). However, after including treatment factors (days of illness at initial IVIG and treatment responsiveness) in the adjusted model, the association was no longer significant (adjusted OR 0.89, 95% CI 0.77 to 1.03), indicating that BCGitis was not an independent factor associated with cardiac complication and might be confounded by treatment factors. CONCLUSIONS: BCGitis was identified in comparatively early illness stages of KD. Our findings indicated that BCGitis was not an independent factor associated with developing cardiac complications but was confounded by prompt initial IVIG administration, which might result in successful treatment and prevention of cardiac complications.
  • Kanako Hayashida, Ryusuke Ae, Hiroya Masuda, Koki Kosami, Masami Matsumura, Nobuko Makino, Yuri Matsubara, Teppei Sasahara, Yosikazu Nakamura
    The Pediatric infectious disease journal 40 (6) 531 - 536 2021/06 
    BACKGROUND: Some patients with Kawasaki disease (KD) have siblings who developed the same disease. Using a large-scale epidemiologic dataset, the present study aimed to determine the clinical characteristics of this population. METHODS: We analyzed 89,725 patients diagnosed with KD during 2011-2018 who were registered in the nationwide Japanese KD survey database. Multivariable logistic regression analyses were performed to determine factors associated with sibling history of KD. RESULTS: Of the 89,725 patients, 1777 (2%) had sibling history of KD. Annual prevalence ranged from 1.5% to 2.3% during the study period and showed a tendency toward an increasing trend. Patients with recurrent KD and parental history of KD were significantly associated with sibling history of KD (adjusted odds ratio [95% confidence interval] = 2.15 [1.82-2.54] and 2.64 [2.02-3.47], respectively). Although patients with a sibling history of KD were significantly associated with initial intravenous immunoglobulin treatment resistance (1.14 [1.02-1.28]), no significant association was found between sibling history and coronary artery abnormality development. Among patients with a sibling history of KD, male patients were less likely to have recurrent KD than female patients (0.68 [0.49-0.96]). CONCLUSIONS: The significant association between sibling history and parental history may indicate genetic susceptibility to KD onset. Among those with a sibling history, recurrent KD was more likely to occur in female patients. Further studies focusing on this population may contribute toward identification of the cause of KD onset.
  • Ryusuke Ae, Ryan A Maddox, Joseph Y Abrams, Lawrence B Schonberger, Yosikazu Nakamura, Masanari Kuwabara, Nobuko Makino, Koki Kosami, Yuri Matsubara, Daisuke Matsubara, Teppei Sasahara, Ermias D Belay
    Journal of the American Heart Association 10 (7) e019853  2021/04 
    Background Detection of coronary artery lesions (CALs) at initial echocardiography can aid in diagnosing Kawasaki disease (KD) and inform primary adjunctive treatments. We aimed to characterize patients with KD with CALs detected at initial echocardiography. Methods and Results We analyzed data from the nationwide Japanese KD survey that contained information on 103 222 population-based patients diagnosed with KD across Japan during 2011 to 2018. Patients with CALs detected at initial echocardiography were assessed by age, day of illness, and number of principal KD signs (≥3). Multivariable logistic regression analysis was performed to evaluate factors independently associated with CAL detection. Overall, 3707 (3.6%) patients had CALs detected at initial echocardiography. Patients aged <12 and ≥60 months were associated with CAL detection (adjusted odds ratio [95% CI], 1.28 [1.18‒1.39] and 1.32 [1.20‒1.45], respectively; reference, 12‒59 months). Patients with delayed hospital visits were increasingly at higher risk for CAL detection (days 7‒8, 1.84 [1.63‒2.08]; days 9-10, 4.30 [3.58-5.15]; and days ≥11, 9.12 [7.63‒10.90]; reference, days 1-4). Patients with 3 or 4 principal KD signs were independently associated with CAL detection (1.75 [1.63‒1.88]). These patients were significantly more likely to be aged <12 months but were not associated with delayed hospital visit. Younger patients visited at earlier days of illness. Conclusions Timely diagnosis could be beneficial for patients with KD. However, even when the hospital visit occurred early in the course of illness, patients with 3 or 4 principal KD signs, especially younger patients, were at higher risk of CAL detection at initial echocardiography.
  • Hiroya Masuda, Ryusuke Ae, Taka-Aki Koshimizu, Masami Matsumura, Koki Kosami, Kanako Hayashida, Nobuko Makino, Yuri Matsubara, Teppei Sasahara, Yosikazu Nakamura
    Pediatric cardiology 42 (4) 969 - 977 2021/04 
    A giant coronary artery (CA) aneurysm is a potentially fatal cardiac complication resulting from Kawasaki disease (KD). We aimed to identify epidemiologic characteristics and potential risk factors associated with giant CA aneurysms identified after acute KD. We analyzed 90,252 patients diagnosed with KD from 2011 to 2018, using data obtained in nationwide KD surveys conducted in Japan. Multivariable logistic regression analyses were performed to evaluate potential risk factors associated with subsequent giant CA aneurysm complications (defined as lumen size ≥ 8 mm), adjusting for all potential factors. Giant CA aneurysms were identified in 144 patients (0.16%) after acute KD. The annual prevalence ranged from 0.07 to 0.20% during the study period. In the multivariate analyses, male sex (adjusted odds ratio 2.09 [95% confidence interval 1.41-3.11], recurrent KD (1.90 [1.09-3.33]), IVIG administration at 1-4 days of illness (1.49 [1.04-2.15]) and ≥ 8 days after KD onset (2.52 [1.38-4.60]; reference, 5-7 days), detection of CA dilatations and aneurysms at initial echocardiography (4.17 [1.85-5.41] and 46.5 [28.8-74.8], respectively), and resistance to IVIG treatment (6.09 [4.23-8.75]) were significantly associated with giant CA aneurysm complications identified after acute KD. The annual prevalence of giant CA aneurysms identified after acute KD did not increase during the study period. Patients with larger CA abnormalities detected at initial echocardiography were independently associated with progression to giant CA aneurysm complications after acute KD regardless of the number of days from onset at treatment initiation.
  • Ryusuke Ae, Nobuko Makino, Koki Kosami, Masanari Kuwabara, Yuri Matsubara, Yosikazu Nakamura
    The Journal of pediatrics 225 23 - 29 2020/10 [Refereed][Not invited]
     
    OBJECTIVE: To report the epidemiologic characteristics, treatments, and cardiac complications of Kawasaki disease, using data from the nationwide survey in Japan. STUDY DESIGN: The nationwide Kawasaki disease survey in Japan has been conducted biennially since 1970. The most recent survey was completed in 2019, obtaining information for patients who developed Kawasaki disease during 2017-2018. Survey respondents were hospitals specializing in pediatrics and those with ≥100 beds and a pediatric department throughout Japan, where patients with Kawasaki disease were eventually hospitalized. RESULTS: The survey identified 32 528 patients with Kawasaki disease, which consisted of 15 164 (46.6%) in 2017 and 17 364 (53.4%) in 2018. The highest annual incidence rate was recorded in 2018 (359 per 100 000 children aged 0-4 years). After 1982, patients with ≤4 principal Kawasaki disease signs gradually increased, resulting in 6847 (21.1%) patients diagnosed during 2017-2018. Among the 30 784 patients receiving initial intravenous immunoglobulin administration, 6061 (19.7%) did not respond. Within 30 days of Kawasaki disease onset, 9.0% of patients were diagnosed with cardiac complications, and 2.6% of patients developed cardiac sequelae after the acute illness. CONCLUSIONS: The annual number of patients developing Kawasaki disease in Japan increased from 1970 through 2018, whereas the proportion of patients with Kawasaki disease with cardiac complications decreased in the most recent 2 decades. Early diagnosis of Kawasaki disease as well as advances in initial treatments could explain these findings.
  • Ryusuke Ae, Joseph Y Abrams, Ryan A Maddox, Lawrence B Schonberger, Yosikazu Nakamura, Masanari Kuwabara, Nobuko Makino, Yuri Matsubara, Koki Kosami, Teppei Sasahara, Ermias D Belay
    Journal of the American Heart Association 9 (17) e015308  2020/09 
    BACKGROUND Randomized controlled trials previously provided different conclusions about the superiority of adding corticosteroids to initial intravenous immunoglobulin treatment for the prevention of coronary artery abnormalities in patients with Kawasaki disease (KD). To further assess this issue, we analyzed large-scale data from nationwide KD surveys in Japan, where combination treatment (corticosteroids added to initial standard intravenous immunoglobulin treatment) has become commonly used for patients at high risk for KD. METHODS AND RESULTS Standard intravenous immunoglobulin treatment and combination treatment were compared using data from time periods with and without combination treatment. Outcome measures were coronary artery abnormalities and initial intravenous immunoglobulin treatment failure. Hospitals where ≥20% of patients received combination treatment were identified, and treatment and control groups were selected via matching by age, sex, illness day at initial treatment, and KD recurrence. Matched group selection and subsequent analyses were conducted 1000 times to minimize sampling bias and potential confounders (bootstrapping). From 115 hospitals, 1593 patients with KD in the treatment group and 1593 controls were selected for each of the 1000 sample iterations. The median proportion of patients who developed coronary artery abnormalities among the treatment group and controls were 4.6% (95% CI, 3.8%-5.8%) and 8.8% (95% CI, 7.5%-10.0%), respectively: an estimated risk ratio of 0.53 (0.41-0.67). A median of 14.1% (95% CI, 12.4%-15.9%) of the patients in the treatment group and 21.7% (95% CI, 19.8%-23.4%) in the controls had treatment failure: an estimated risk ratio of 0.65 (0.56-0.75). CONCLUSIONS Combination treatment reduced coronary artery abnormality risk by an estimated 47% and treatment failure by 35%. Multiple-dose corticosteroids may provide benefit in selected patients at high risk for KD.
  • Ryusuke Ae, Joseph Y Abrams, Ryan A Maddox, Lawrence B Schonberger, Yosikazu Nakamura, Masanari Kuwabara, Nobuko Makino, Yuri Matsubara, Daisuke Matsubara, Koki Kosami, Teppei Sasahara, Ermias D Belay
    American heart journal 225 120 - 128 2020/07 [Refereed][Not invited]
     
    BACKGROUND: Previous studies demonstrated that coronary artery lesions (CALs) resulting from Kawasaki disease (KD) can improve over time. However, limited information is available on sub-acute outcomes of CALs detected at admission during KD illness. METHODS: The nationwide Japanese KD survey contained substantial information on KD patients with CALs detected at admission and who received standard IVIG treatment within 10 days of disease onset. Coronary outcomes were evaluated by changes in CALs from admission to the first assessment at 30 days from disease onset in three categories: improved, unchanged, and progressed. Ordinal logistic regression analysis was performed to evaluate factors associated with the outcomes. RESULTS: Of 2024 patients with CALs detected at admission, improved, unchanged, and progressed outcomes were found in 1548 (76.5%), 390 (19.3%), and 86 (4.2%), respectively. Over 80% of patients with coronary artery (CA) dilatations had improved outcome. Independent factors associated with worse outcomes were larger-size CALs (adjusted ORs [95% CIs]: CA aneurysm = 5.13 [3.65-7.22] and giant CA aneurysms = 7.49 [3.56-15.72] compared with CA dilatation, respectively), age ≥ 60 months (1.45 [1.08-1.94] compared with 12-59 months), recurrent KD (1.57 [1.07-2.29]), parental history of KD (2.23 [1.02-4.85]), and delayed admission (8-10 days from disease onset: 1.76 [1.21-2.57] compared with 1-4 days). CONCLUSIONS: KD patients with larger CALs, ≥60 months old, and with recurrent status or parental history may require more rigorous treatment. In addition, delayed admission may result in worse coronary outcome, indicating that prompt diagnosis and treatment are required.
  • Yuri Matsubara, Daisuke Matsubara, Ryusuke Ae, Koki Kosami, Yasuko Aoyama, Mayumi Yashiro, Nobuko Makino, Shigeki Matsubara, Yosikazu Nakamura
    Pediatrics international : official journal of the Japan Pediatric Society 62 (4) 444 - 450 2020/04 [Refereed][Not invited]
     
    BACKGROUND: Some patients with Kawasaki disease (KD) develop cardiac sequelae, which increase the risk of subsequent ischemic heart events. Knowing the cumulative incidence (CI) of KD with cardiac sequelae may contribute to developing health policies to prevent subsequent ischemic events in these patients. METHODS: Study participants consisted of 254 984 patients aged 0-9 years with KD who were registered in nationwide surveys in Japan from 1991-2016. We calculated the incidence probabilities by dividing the number of patients with KD aged 0-9 years by the population used in vital statistics of each calendar year. We calculated the cumulative proportion of those not affected by KD, by multiplying each probability in patients aged from age 0-9 years. The CI of KD was obtained by subtracting this value from 1. We also calculated the number of patients in each birth cohort (BC). The same was done to calculate the CI of KD-related cardiac sequelae. RESULTS: The CIBC steadily increased from 0.005067 in males and 0.003668 in females in 1991 to 0.011431 in males and 0.0088253 in females in 2007. The CIBC of KD with cardiac sequelae decreased from 0.000478 in males and 0.000213 in females in 1997 to 0.000339 in males and 0.000169 in females in 2007. CONCLUSION: The increasing CIBC of KD indicates an increased susceptibility to KD in accordance with birth year. The decreasing CIBC of cardiac sequelae suggests the efficacy of KD treatment.
  • 脊椎関節炎をめぐる最近の動向と今後の展開 体軸性脊椎関節炎の最近の動向と今後の展開
    冨田 哲也, 松原 優里, 辻 成佳, 玉城 雅史, 中村 好一
    中部日本整形外科災害外科学会雑誌 (一社)中部日本整形外科災害外科学会 63 (春季学会) 48 - 48 0008-9443 2020/04 [Refereed][Not invited]
  • Ryusuke Ae, Joseph Y Abrams, Ryan A Maddox, Lawrence B Schonberger, Yosikazu Nakamura, Asuka Shindo, Masanari Kuwabara, Nobuko Makino, Yuri Matsubara, Koki Kosami, Teppei Sasahara, Ermias D Belay
    The Pediatric infectious disease journal 39 (3) 197 - 203 2020/03 [Refereed][Not invited]
     
    BACKGROUND: Platelet count is considered as a biomarker for the development of coronary artery abnormalities (CAAs) among Kawasaki disease (KD) patients. However, previous studies have reported inconsistent results. We addressed the controversial association of platelet count with CAAs using a large-scale dataset. METHODS: A retrospective cohort study was conducted using KD survey data from Japan (2015-2016; n = 25,448). Classifying patients by intravenous immunoglobulin (IVIG) responsiveness, we described the trends in platelet count using the lowest and highest values along with the specific illness days. Multivariate logistic regression analysis was performed to evaluate the association between platelet count and CAAs, adjusting for relevant factors. RESULTS: Platelet counts rapidly decreased from admission, reached the lowest count at 6-7 days, and peaked after 10 days. Platelet counts in IVIG non-responders decreased with a lower minimum value than IVIG responders, but subsequently rebounded toward a higher maximum. Compared with patients with normal platelet counts (150-450 × 10/L), patients with abnormally high platelet counts (>450 × 10/L) were more likely to have CAAs at admission (adjusted odds ratio: IVIG responders, 1.50 [95% confidence interval 1.20-1.87] and non-responders, 1.46 [1.01-2.12]). By contrast, IVIG non-responding patients whose counts were below normal (<150 × 10/L) after hospitalization were at higher risk for developing CAAs (2.27 [1.44-3.58]). CONCLUSIONS: Platelet count varied widely by illness day and was confounded by IVIG responsiveness, which might have contributed to previous inconsistent findings. KD patients with abnormally high platelet counts at admission or abnormally low counts after hospitalization were at higher risk for CAAs.
  • Nozomi Yokota, Ryusuke Ae, Masaki Amenomori, Koji Kitagawa, Takuya Nakamura, Tetsuro Yokota, Kato Masato, Teppei Sasahara, Yuri Matsubara, Koki Kosami, Yoshikazu Nakamura
    Journal of general and family medicine 20 (4) 139 - 145 2189-6577 2019/07 [Refereed][Not invited]
     
    Objective: Few studies have reported the influence of clinical background factors on the outcome of Helicobacter pylori eradication therapy in primary care practice. We aimed to determine which clinical background factors influence the outcome of eradication therapy in a primary care setting. Methods: This was a retrospective study of patients who received H pylori eradication therapy at Higashiohmi City Gamo Medical Center, Shiga, Japan, from January 2012 to December 2015. We investigated clinical background factors associated with success, failure, and self-interruption of H pylori eradication therapy: patients' age, gender, first- or second-line treatment, reasons for receiving gastroenterological endoscopic examination, method of drug administration, and attending physicians' age and their specialties. Results: There were 369 patients (208 females, 161 male), with a mean age of 59 years (range 30-88 years). The middle-aged group (50-69 years) was associated with successful eradication therapy compared with the young group (30-49 years). The elderly group (>70 years) was associated with eradication therapy failure compared with the middle-aged group. The young group was associated with self-interruption of eradication therapy. There was a marginally significant association between male patients and self-interruption. Older attending physicians (>50 years) were also associated with failure compared with younger physicians. There was no difference in outcome of eradication therapy between generalists and gastroenterology specialists. Conclusion: We have identified clinical factors associated with success, failure, and self-interruption of H pylori eradication therapy in a primary care setting.
  • Shinji Kido, Ryusuke Ae, Koki Kosami, Yuri Matsubara, Nobuko Makino, Teppei Sasahara, Masanari Kuwabara, Yasuko Aoyama, Mayumi Yashiro, Hiroshi Yanagawa, Yosikazu Nakamura
    Pediatrics international : official journal of the Japan Pediatric Society 61 (6) 539 - 543 1328-8067 2019/06 [Refereed][Not invited]
     
    BACKGROUND: Evidence suggests that seasonal variation in the onset of Kawasaki disease (KD) exists worldwide. Whether a seasonal component to successful i.v. immunoglobulin (IVIG) therapy exists in KD-positive children, however, is unknown. We addressed this question by focusing on patients with primary onset KD who were non-responsive to IVIG treatment, in the large nationwide Japanese KD survey datasets from 2009 to 2016. METHODS: In these datasets, the IVIG therapy non-responders were defined as patients whose fever persisted ≥24 h or recurred ≤24 h after the end of the initial IVIG treatment (dosage, 2,000 mg/kg). Those who successfully responded to this treatment were defined as IVIG responders. The consecutive monthly trend of the proportion of IVIG non-responders was analyzed throughout the study period to investigate seasonal periodicity on Fourier analysis, and the monthly distributions of non-responders and responders were compared. RESULTS: From a total of 113 691 KD-positive patients, 15.7% were IVIG non-responders, and 61% were male. The proportion of non-responders increased across each calendar year with fluctuation, and Fourier analysis indicated seasonal periodicity. The seasonality effect differed between responders and non-responders, with the proportion of responders tending to increase in autumn through winter, while the non-responders showed a decreasing trend in autumn. The seasonality effect tended to differ by sex. CONCLUSIONS: The results indicate that the currently unknown etiological agents of KD might differ between IVIG responders and non-responders. In addition, immune reactivity against such agents possibly differs by sex in the IVIG non-responders.
  • Nobuko Makino, Yosikazu Nakamura, Mayumi Yashiro, Koki Kosami, Yuri Matsubara, Ryusuke Ae, Yasuko Aoyama, Hiroshi Yanagawa
    Pediatrics international : official journal of the Japan Pediatric Society 61 (4) 397 - 403 1328-8067 2019/04 [Refereed][Not invited]
     
    BACKGROUND: Approximately 50 years have passed since Kawasaki disease (KD) was first reported. The KD nationwide survey began in 1970. Although >360 000 cases have already been reported in Japan, the cause is still unknown. In Japan, the number of patients and incidence rate of KD has continued to increase. It is necessary to examine the trend of the occurrence in the surveillance of KD. METHODS: The nationwide survey of patient incidence in 2015 and 2016 was conducted in 2017, as the 24th nationwide survey of KD. A questionnaire was sent to pediatric departments in hospitals with >100 beds and specialized pediatric hospitals, and was responded to by the attending pediatricians. RESULTS: The total number of patients in 2 years was 31 595, and the sex ratio (male/female) was 1.34. The incidence rate (/100 000 children aged 0-4 years/year) was 330.2 (371.2 in boys, 287.3 in girls) in 2015, and 309.0 (343.2 in boys, 273.2 in girls) in 2016. The number of patients by month peaked in January. The age-specific incidence rate according to sex was highest in children between 9 and 11 months of age, after which the incidence rate gradually decreased with advancing age. CONCLUSIONS: We summarize the most recent nationwide survey of KD and consider the change in the epidemiologic picture.
  • 体軸性脊椎関節炎の診療 non-radiographic(X線基準を満たさない)axial SpAの本邦での現状
    冨田 哲也, 松原 優里, 中村 好一
    日本リウマチ学会総会・学術集会プログラム・抄録集 (一社)日本リウマチ学会 63回 244 - 244 2019/03 [Refereed][Not invited]
  • 強直性脊椎関節炎全国疫学調査
    冨田 哲也, 松原 優里, 中村 好一
    中部日本整形外科災害外科学会雑誌 (一社)中部日本整形外科災害外科学会 62 (春季学会) 100 - 100 0008-9443 2019/03 [Refereed][Not invited]
  • Izumi Chihara, Ryusuke Ae, Yuka Kudo, Ritei Uehara, Nobuko Makino, Yuri Matsubara, Teppei Sasahara, Yasuko Aoyama, Kazuhiko Kotani, Yosikazu Nakamura
    BMC Psychiatry 18 (1) 112  1471-244X 2018/04 [Refereed][Not invited]
     
    Background: In Japan, although many suicidal studies were previously conducted in tertiary emergency department (ED) settings, no published studies have reported on suicidal patients presenting to the secondary EDs. The aim of the study was to describe the characteristics of suicidal patients and the referral rates to a psychiatrist overall and by type of facility. Methods: Questionnaires were sent to all secondary and tertiary EDs in Tochigi prefecture, Japan. Data were collected for cases who presented in September 2009. Chi-square, Fisher's exact, and t-tests compared the results by gender and type of ED. Results: All 74 EDs responded to the survey. There were 81 patients who attempted or died by suicide (36 men and 45 women). The most common method of suicide attempt was drug overdose (57%) followed by stabbing (17%). About a half used prescription drugs to attempt or die by suicide. The majority had a history of psychiatric disorders, and 35% had previous suicide attempt. About a half were admitted to medical or surgical unit 33% were discharged home and 9% died. After excluding those who died, 53% were referred to a psychiatrist, but 47% were not referred to a psychiatrist. The referral rate was lower for cases seen at secondary EDs (38%) compared to tertiary EDs (67%). Conclusion: Although professional organizations suggest that suicidal patients are seen by a psychiatrist, many were not, especially at secondary EDs. Further research is needed to assure that suicidal patients presenting to EDs receive appropriate psychiatric assessment and follow-up after discharge.
  • 地方紙に掲載された自己申告型死亡記事
    中村 好一, 松原 優里, 笹原 鉄平, 古城 隆雄, 阿江 竜介, 青山 泰子, 牧野 伸子, 小池 創一, 石川 鎮清
    日本公衆衛生雑誌 日本公衆衛生学会 65 (2) 72 - 82 0546-1766 2018/02 [Not refereed][Not invited]
     
    目的 地方紙における遺族の自己申告型死亡記事の記載事項を集計し、その地域での死亡やそれに伴う儀式の実態を明らかにするとともに、死亡記事のデータベースとしての利点と問題点を明らかにする。方法 栃木の地方紙である下野新聞の自己申告型死亡記事「おくやみ」欄に掲載された2011〜2015年の栃木県内の死亡者全員のデータを集計解析し、一部の結果は人口動態統計と比較した。観察項目は掲載年月日、市町村、住所の表示(市町村名のみ、町名・字まで、番地まで含めた詳細な住所)、氏名、性別、死亡年月日、死因、死亡時年齢、通夜・告別式などの名称、通夜などの年月日、告別式などの年月日、喪主と喪主の死亡者との続柄の情報である。結果 観察期間中の掲載死亡者数は69,793人で、同時期の人口動態統計による死亡者数の67.6%であった。人口動態統計と比較した掲載割合は男女で差がなく、小児期には掲載割合が低く、10歳代で高く、20歳代で低下し、以降は年齢とともに上昇していた。市町別の掲載割合は宇都宮市や小山市など都市化が進んだ地域では低く、県東部や北部で高い市町がみられた。最も掲載割合が高かったのは茂木町(88.0%)、低かったのは野木町(38.0%)であった。死亡日から通夜や告別式などの日数から、東京などで起こっている火葬場の供給不足に起因する火葬待ち現象は起こっていないことが判明した。六曜の友引の日の告別式はほとんどなく、今後、高齢者の増加に伴う死者の増加によって火葬場の供給不足が起こった場合には、告別式と火葬を切り離して友引に火葬を行うことも解決策の1つと考えられた。死亡者の子供、死亡者の両親、死亡者の子供の配偶者が喪主の場合には、喪主は男の方が多いことが判明した。老衰、自殺、他殺の解析から、掲載された死因の妥当性は低いことが示された。結論 栃木県の地方紙である下野新聞の自己申告型死亡記事「おくやみ」欄の5年分の観察を行い、実態を明らかにした。約3分の2に死亡が掲載されており、データベースとしての使用に一定の価値があると考えられたが、記載された死因の妥当性は低いことが判明した。(著者抄録)
  • Nakamura Y, Matsubara Y, Sasahara T, Kojo T, Ae R, Aoyama Y, Makino N, Koike S, Ishikawa S
    [Nihon koshu eisei zasshi] Japanese journal of public health 65 (2) 72 - 82 0546-1766 2018 [Refereed][Not invited]
     
    Objectives To reveal the features of death and subsequent funeral services, we analyzed self-reported obituaries in The Shimotsuke, a local daily newspaper in Tochigi, Japan. In addition, the usefulness and disadvantages of such a database of deaths based on the obituaries were discussed.Method For a 5-year period, from January 2011 through December 2015, all the obituary columns in The Shimotsuke were computerized as a database and analyzed. Some results were compared with the vital statistics data in the corresponding period of time. Data analyzed were: dead persons' address (municipalities), name, sex, cause of death, age at death, date of death and funeral services, the chief mourner (Moshu), and so on.Results During the observed 5-year period, 69,793 deaths appeared in the columns, which were 67.6% of the all deaths in the vital statistics. No difference was observed in the proportions between the sexes in the published deaths in comparison with the vital statistics. In both sexes, the proportion was low in 0-9 years old, then high among 10-19 years, decreasing in 20s, and after then the proportion increased according to the age. The proportion was low in city areas, such as Utsunomiya and Oyama, and high in some cities and towns in the northern or eastern parts of Tochigi prefecture. The highest was in Motegi Town (88.0%), and the lowest was Nogi Town (38.0%), which is located in the southern-most part of the prefecture and is closest to the Tokyo metropolitan area. Almost all the funeral services were conducted within a week of the death, and no delays were observed to have been caused by the short supply of cremation services, which exists in large cities in Japan. In case where the chief mourner was a child, a parent, or a spouse of a child, the male sex was dominant. Analyses of death from senile decay, suicide, and homicide indicated that the accuracy of the published cause of death was low. The date of the funeral services was strongly influenced by superstitions in this country.Conclusions Observations of the self-reported obituaries in a local daily newspaper over five years revealed the situations of the deaths in the area that could not be observed using vital statistics. Despite limitations, the information was partially useful as a database.
  • Ae R, Nakamura Y, Tada H, Kono Y, Matsui E, Itabashi K, Ogawa M, Sasahara T, Matsubara Y, Kojo T, Kotani K, Makino N, Aoyama Y, Sano T, Kosami K, Yamashita M, Oka A
    Journal of epidemiology 28 (6) 300 - 306 0917-5040 2018/01 [Refereed][Not invited]
     
    BACKGROUND: Globally, few published studies have tracked the temporal trend of dioxin levels in the human body since 2000. This study describes the annual trend of dioxin levels in human breast milk in Japanese mothers from 1998 through 2015. METHODS: An observational study was conducted from 1998 through 2015. Participants were 1,194 healthy mothers following their first delivery who were recruited annually in Japan. Breast milk samples obtained from participants were analyzed using gas chromatography and mass spectrometry for dioxins, including polychlorinated dibenzo-p-dioxins (PCDDs), polychlorinated dibenzofurans (PCDFs), and coplanar polychlorinated biphenyls (PCBs). RESULTS: Mean age was 29.5 years, and 53% of participants were 20-25 years old. A declining trend in total dioxin levels was found, from a peak of 20.8 pg toxic equivalence (TEQ)/g fat in 1998 to 7.2 pg TEQ/g fat in 2014. Data from the last 5 years of the study indicated a plateau at minimal levels. In contrast, an increasing trend was found in the mean age of participants during the last 5 years. Although significantly higher dioxin levels were observed in samples from older participants, an upward trend in dioxin levels was not observed, indicating that dietary and environmental exposure to dioxins had greatly diminished in recent years. CONCLUSIONS: Dioxin levels in human breast milk may be approaching a minimum in recent years in Japan. The findings may contribute to global reference levels for environmental pollution of dioxins, which remains a problem for many developing countries.
  • Yuri Matsubara, Hitoshi Osaka, Takanori Yamagata, Ryusuke Ae, Jun Shimizu, Noriko Oguro
    Brain and Development 40 (9) 807 - 812 1872-7131 2018 [Refereed][Not invited]
     
    Background: Acute encephalopathy causes various sequelae, including motor disabilities and intellectual delays. Previous studies reported that cognitive impairments can also occur after acute encephalitis. Although the incidence of acute encephalopathy is high in Japan, there have been few reports on its sequelae. Objective: To characterize the neurological outcomes of pediatric patients who sought motor rehabilitation for motor dysfunction after acute encephalopathy. Method: Subjects were 26 children who were healthy before suffering from motor dysfunction following acute encephalopathy and were referred to our pediatric rehabilitation institute during a 9-year period (August 2007–April 2017). We examined subjects’ neurological status and followed sequelae for at least 8 months. Results: Of 26 individuals, 21 became ambulatory after several months or years during the observation period. Patients who could sit without support within 5 months after the onset of acute encephalopathy were able to walk within several months or years. Patients showing high intensity on T2-weighted sequences or “bright tree appearance” in the frontal region took an average of 7 months to develop walking, which was longer than other patients. Among ambulatory subjects, 16(76%) exhibited mild to moderate intellectual delay with a developmental quotient (DQ) under 70, and 20 (95%) exhibited cognitive impairment. There was a significant correlation between DQ scores and motor disability (p = 0.013, r = −0.481). Conclusions: Although 80% of patients who had motor dysfunction caused by acute encephalopathy and visited out motor rehabilitation outpatient clinic were eventually able to walk, the time taken to develop walking ability depended on which region exhibited magnetic resonance imaging abnormalities. DQ scores and motor disability were significantly correlated.
  • Matsubara Y, Ae R, Ohya Y, Akiyama H, Imai T, Matsumoto K, Fukuie T, Aoyama Y, Makino N, Nakamura Y, Saito H
    Arerugi = [Allergy] 67 (6) 767 - 773 0021-4884 2018 [Refereed][Not invited]

MISC

  • 全国サーベイランスに基づくわが国のプリオン病の記述疫学(1999-2020)
    小佐見 光樹, 阿江 竜介, 中村 好一, 牧野 伸子, 青山 泰子, 松原 優里, 浜口 毅, 山田 正仁, 水澤 英洋  Journal of Epidemiology  31-  (Suppl.)  110  -110  2021/01
  • Google APIを用いた位置座標特定による川崎病クラスターの抽出(1989-1998)
    佐野 尭, 牧野 伸子, 阿江 竜介, 小佐見 光樹, 松原 優里, 中村 好一  日本公衆衛生学会総会抄録集  79回-  323  -323  2020/10
  • 色素性乾皮症全国疫学調査
    石川 鎮清, 小佐見 光樹, 松原 優里, 阿江 竜介, 青山 泰子, 牧野 伸子, 錦織 千佳子, 中村 好一  日本公衆衛生学会総会抄録集  79回-  411  -411  2020/10
  • 松原 優里, 青山 泰子, 小佐見 光樹, 阿江 竜介, 牧野 伸子, 石川 鎮清, 中村 好一  日本小児科学会雑誌  124-  (8)  1224  -1233  2020/08  
    栃木県の調査データを二次利用し、在宅医療的ケア児の生活状況について分析した。医療的ケア児は県内に約300人、20歳未満人口1000人対0.91みられ、年齢分布では6歳未満が50%を占め、寝たきりや座位の児が50%、歩行や走ることが可能な児が31%であった。サービスについては人工呼吸器使用者で「送迎がない」「利用できるサービスの量が不足」「費用負担が大きい」などの項目が有意に高かった。また、介護者で睡眠5時間未満の者は児に経管栄養がある場合において有意に高かった。以上、これらの結果からも、在宅医療的ケア児の運動・知的機能には個人差があり、個々に応じたサービスの提供が必要であると考えられた。
  • 脊椎関節炎をめぐる最近の動向と今後の展開 体軸性脊椎関節炎の最近の動向と今後の展開
    冨田 哲也, 松原 優里, 辻 成佳, 玉城 雅史, 中村 好一  中部日本整形外科災害外科学会雑誌  63-  (春季学会)  48  -48  2020/04
  • 地域剥奪指標と東京・大阪における川崎病発生率との関係(1993-1998)
    佐野 尭, 牧野 伸子, 青山 泰子, 小佐見 光樹, 松原 優里, 中村 好一  日本公衆衛生学会総会抄録集  78回-  309  -309  2019/10
  • 乳幼児歯科健診データを用いた下野市のむし歯罹患に関連する要因の検討
    間中 沙織, 山崎 泰世, 佐藤 有希恵, 萩原 栞, 小川 正実, 大橋 俊子, 中山 竜司, 阿江 竜介, 松原 優里  栃木県公衆衛生学会抄録集  57回-  37  -39  2019/09  
    下野市では、1歳6ヵ月児健診時から3歳児健診時までの間における齲蝕罹患者割合の増加率が県平均に比べて高いため、この間の齲蝕予防を図る目的で平成28年度から2歳児歯科検診を導入した。今回、この対策が有効であったか調査するとともに、生活環境や養育環境の違いが齲蝕の発生とどの程度関連しているか検討した。対象は29年度に3歳児健診を受けた児のうち、1歳6ヵ月児健診と2歳児歯科検診も受けていた345名とし、健診(または検診)毎の齲蝕罹患者割合および新規罹患者割合について調査するとともに、健診(または検診)毎の齲蝕リスク要因について検討した。結果、齲蝕罹患者割合は1歳6ヵ月児健診時が0.86%、2歳児歯科検診時7.24%、3歳児健診時12.75%、新規罹患者割合は2歳児歯科検診時7%、3歳児健診時8.5%であり、2歳児歯科検診導入による明らかな効果はみられなかった。1歳6ヵ月児健診時における齲蝕リスク要因として「兄弟との同居」「間食の制限なし」などが抽出され、2歳児健診時におけるリスク要因として「出生順位(第二子以降)」「かかりつけ歯科医なし」、3歳児健診時のリスク要因として「甘い飲み物をよく飲む」が抽出された。
  • 栃木県における臨床検査技師の在宅医療への関与についての考察
    奥山 啓子, 岡本 その子, 枝 明日美, 渡辺 佳津子, 谷中 弘一, 荒川 正子, 中村 好一, 松原 優里, 青山 旬  栃木県公衆衛生学会抄録集  57回-  127  -129  2019/09  
    県内の在宅療養支援診療所または在宅療養支援病院151施設に質問紙を郵送し、「臨床検査技師による在宅訪問の有無」「臨床検査項目」「抗体検査・生理検査の実施状況」「在宅医療に臨床検査技師が必要だと思うか」などについて尋ねた。129施設から回答が得られ、このうち臨床検査技師が在宅訪問を実施していたのは4施設(3%)であった。臨床検査項目は血球算定(80%)、血糖・HbA1c(78%)など血液検査が多く、尿検査や感染症検査は約半数、アンモニアや凝固検査は約1/4の施設で実施していた。抗体検査は112例(87%)、生理検査は79施設(61%)で実施していた。在宅医療に臨床検査技師が「必要」と答えたのは27施設(21%)、「必要ない」が30施設(23%)、「どちらとも言えない」が64施設(50%)であった。「必要」「必要ない」「どちらとも言えない」と答えた施設からそれぞれ2施設ずつ抽出した計6施設の医師等6名と、臨床検査技師が在宅訪問を実施している施設から抽出した3施設の臨床検査技師にインタビューを行い、「在宅医療における臨床検査技師の関与」「在宅訪問をしている臨床検査技師の現状と課題」などについて聴取したので併せて報告した。
  • 強直性脊椎関節炎全国疫学調査
    冨田 哲也, 松原 優里, 中村 好一  中部日本整形外科災害外科学会雑誌  62-  (春季学会)  100  -100  2019/03  [Not refereed][Not invited]
  • 体軸性脊椎関節炎の診療 non-radiographic(X線基準を満たさない)axial SpAの本邦での現状
    冨田 哲也, 松原 優里, 中村 好一  日本リウマチ学会総会・学術集会プログラム・抄録集  63回-  244  -244  2019/03  [Not refereed][Not invited]
  • 小佐見光樹, 阿江竜介, 中村好一, 牧野伸子, 青山泰子, 松原優里, 浜口毅, 山田正仁, 水澤英洋  日本疫学会学術総会講演集(Web)  29th-  162 (WEB ONLY)  2019/01  [Not refereed][Not invited]
  • 日本におけるSpA診断の現状と課題・今後の展望
    冨田 哲也, 松原 優里, 中村 好一  日本脊椎関節炎学会誌  (Suppl.)  29  -29  2019
  • 体軸性脊椎関節炎全国疫学調査
    冨田 哲也, 松原 優里, 中村 好一  日本脊椎関節炎学会誌  (Suppl.)  40  -40  2019
  • 栃木県県南健康福祉センター管内における要支援妊婦の評価と選定基準の統一化
    生井 明美, 親松 由佳, 三宅 志穂, 横田 亜樹子, 深津 静枝, 古城 隆雄, 松原 優里, 工藤 香織, 大橋 俊子  日本公衆衛生学会総会抄録集  77回-  399  -399  2018/10
  • 栃木県における医療的ケア児の生活状況と課題
    松原 優里, 青山 泰子, 小佐見 光樹, 阿江 竜介, 牧野 伸子, 中村 好一  日本公衆衛生学会総会抄録集  77回-  460  -460  2018/10
  • 日本全国におけるPM2.5値と川崎病発生との関連(2011年4月-2016年3月)
    佐野 尭, 牧野 伸子, 青山 泰子, 阿江 竜介, 松原 優里, 小佐見 光樹, 中村 好一  日本公衆衛生学会総会抄録集  77回-  318  -318  2018/10  [Not refereed][Not invited]
  • 栃木県における医療的ケア児及び重症心身障害児を支える資源調査結果
    青山 泰子, 松原 優里, 小佐見 光樹, 阿江 竜介, 牧野 伸子, 中村 好一  日本公衆衛生学会総会抄録集  77回-  460  -460  2018/10  [Not refereed][Not invited]
  • 要支援妊婦の評価と選定基準の統一化
    親松 由佳, 三宅 志穂, 生井 明美, 横田 亜樹子, 小池 彩, 小野口 沙紀, 深津 静枝, 古城 隆雄, 松原 優里, 工藤 香織, 大橋 俊子  栃木県公衆衛生学会抄録集  56回-  51  -53  2018/09  [Not refereed][Not invited]
  • Down症候群に合併した自閉スペクトラム症の特徴
    松原 優里, 小黒 範子, 清水 純, 小坂 仁, 山形 崇倫  小児科臨床  71-  (7)  1307  -1314  2018/07  [Not refereed][Not invited]
     
    近年、Down症候群児の自閉スペクトラム症(autism spectrum disorder:ASD)合併例が散見される。この特性の理解は、より専門的な支援に重要である。2007年4月から2016年4月に外来受診したDown症候群児58人を対象に、発達指数および特性を後方視的に調査し、ASD合併有無による違いを比較した。58人中5人(8.6%)にASDが合併し、ASD合併例(n=5)の平均発達指数は32.2で、ASD非合併例(n=53)のそれら平均値44.8に比し低値であった。ASD合併全例で対人意識の希薄性など、社会コミュニケーション障害を認めたが、母子通園利用中は、呼名反応や挨拶に応じ、親和性が高いと記録されていた。しかし、4ないし5歳でこだわり、耳ふさぎなどの症状が出現し、学齢期にASDと診断される症例がみられた。ASD合併の早期診断のためには長期フォローアップが必要である。(著者抄録)
  • 松原 優里, 阿江 竜介, 大矢 幸弘, 穐山 浩, 今井 孝成, 松本 健治, 福家 辰樹, 青山 泰子, 牧野 伸子, 中村 好一, 斎藤 博久  アレルギー  67-  (6)  767  -773  2018/07  [Not refereed][Not invited]
     
    【背景・目的】日本における食物アレルギー患者数は年々増加しているが、食物アレルギー患者数の頻度分布(有病率)は、未だ明らかではない。本研究では、それらを明らかにし、新たな調査方法を検討する。【方法】政府統計等利用可能な資料を用いて、食物アレルギー患者数を推計する。【結果】乳幼児期では「自己申告」で約80万人、「医師の診断」で約30万〜50万人、学齢期では「自己申告」で約60万人、「医師の診断」で約35万人と推計された。成人では、消費者庁が即時型症状の受診者数を調査しているが、対象が限定されており、患者数の推計は困難であった。【結語】乳幼児はエコチル調査に症状や診断の有無・血液検査を追加することで、年次変化を把握でき、学齢期では文部科学省の調査が有効である。成人期では大規模調査は少なく、国民健康・栄養調査や国民生活基礎調査などに付随した調査が有効である。一方で個々の情報源の抱える問題点も明らかにした。(著者抄録)
  • 松原 優里, 小黒 範子, 清水 純, 小坂 仁, 山形 崇倫  小児科臨床  71-  (7)  1307  -1314  2018/07  [Not refereed][Not invited]
  • 阿江竜介, 中村好一, 牧野伸子, 青山泰子, 松原優里, 浜口毅, 山田正仁, 水澤英洋  日本疫学会学術総会講演集(Web)  28th-  98 (WEB ONLY)  2018/02  [Not refereed][Not invited]
  • 松原優里, 阿江竜介, 青山泰子, 牧野伸子, 中村好一  日本疫学会学術総会講演集(Web)  28th-  106 (WEB ONLY)  2018/02  [Not refereed][Not invited]
  • 佐野尭, 牧野伸子, 青山泰子, 阿江竜介, 松原優里, 中村好一, 柳川洋  日本疫学会学術総会講演集(Web)  28th-  127 (WEB ONLY)  2018/02  [Not refereed][Not invited]
  • 中村 好一, 松原 優里, 笹原 鉄平, 古城 隆雄, 阿江 竜介, 青山 泰子, 牧野 伸子, 小池 創一, 石川 鎮清  日本公衆衛生雑誌  65-  (2)  72  -82  2018/02  [Not refereed][Not invited]
     
    目的 地方紙における遺族の自己申告型死亡記事の記載事項を集計し、その地域での死亡やそれに伴う儀式の実態を明らかにするとともに、死亡記事のデータベースとしての利点と問題点を明らかにする。方法 栃木の地方紙である下野新聞の自己申告型死亡記事「おくやみ」欄に掲載された2011〜2015年の栃木県内の死亡者全員のデータを集計解析し、一部の結果は人口動態統計と比較した。観察項目は掲載年月日、市町村、住所の表示(市町村名のみ、町名・字まで、番地まで含めた詳細な住所)、氏名、性別、死亡年月日、死因、死亡時年齢、通夜・告別式などの名称、通夜などの年月日、告別式などの年月日、喪主と喪主の死亡者との続柄の情報である。結果 観察期間中の掲載死亡者数は69,793人で、同時期の人口動態統計による死亡者数の67.6%であった。人口動態統計と比較した掲載割合は男女で差がなく、小児期には掲載割合が低く、10歳代で高く、20歳代で低下し、以降は年齢とともに上昇していた。市町別の掲載割合は宇都宮市や小山市など都市化が進んだ地域では低く、県東部や北部で高い市町がみられた。最も掲載割合が高かったのは茂木町(88.0%)、低かったのは野木町(38.0%)であった。死亡日から通夜や告別式などの日数から、東京などで起こっている火葬場の供給不足に起因する火葬待ち現象は起こっていないことが判明した。六曜の友引の日の告別式はほとんどなく、今後、高齢者の増加に伴う死者の増加によって火葬場の供給不足が起こった場合には、告別式と火葬を切り離して友引に火葬を行うことも解決策の1つと考えられた。死亡者の子供、死亡者の両親、死亡者の子供の配偶者が喪主の場合には、喪主は男の方が多いことが判明した。老衰、自殺、他殺の解析から、掲載された死因の妥当性は低いことが示された。結論 栃木県の地方紙である下野新聞の自己申告型死亡記事「おくやみ」欄の5年分の観察を行い、実態を明らかにした。約3分の2に死亡が掲載されており、データベースとしての使用に一定の価値があると考えられたが、記載された死因の妥当性は低いことが判明した。(著者抄録)
  • 阿江竜介, 中村好一, 牧野伸子, 青山泰子, 古城隆雄, 松原優里  日本公衆衛生学会総会抄録集  76th-  662  -662  2017/10  [Not refereed][Not invited]
  • 佐野尭, 牧野伸子, 青山泰子, 阿江竜介, 松原優里, 古城隆雄, 小谷和彦, 中村好一, 柳川洋  日本公衆衛生学会総会抄録集  76th-  396  -396  2017/10  [Not refereed][Not invited]
  • Down症候群児に合併した自閉症スペクトラムの特徴
    松原 優里, 清水 純, 小黒 範子, 小坂 仁, 山形 崇倫  脳と発達  49-  (Suppl.)  S305  -S305  2017/05  [Not refereed][Not invited]
  • 佐野尭, 牧野伸子, 青山泰子, 阿江竜介, 松原優里, 屋代真弓, 長谷部圭亮, 南孝臣, 中村好一  日本川崎病学会学術集会抄録集  37th-  112  2017  [Not refereed][Not invited]
  • 松原優里, 阿江竜介, 屋代真弓, 牧野伸子, 中村好一  日本川崎病学会学術集会抄録集  37th-  64  2017  [Not refereed][Not invited]
  • 急性脳症後遺症の予後と長期にわたる支援の必要性について
    松原 優里, 清水 純, 小黒 範子  日本小児科学会雑誌  119-  (6)  1048  -1048  2015/06  [Not refereed][Not invited]
  • アトモキセチン経口液剤使用例の現状と課題
    清水 純, 小黒 範子, 松原 優里  脳と発達  47-  (Suppl.)  S365  -S365  2015/05  [Not refereed][Not invited]
  • 松原 優里, 四方 あかね  周産期医学  43-  (2)  239  -243  2013/02  [Not refereed][Not invited]
  • Hemiconvulsion-Hemiplegia-Epilepsy-syndrome(HHE)症候群の1例
    城本 高志, 福原 進一, 野口 基視, 松原 優里, 高里 良宏, 佐藤 武志, 小島 拓朗, 高橋 努, 上山 泰淳, 井原 正博  日本小児科学会雑誌  112-  (7)  1148  -1148  2008/07  [Not refereed][Not invited]
  • 学校で心肺停止となり救急搬送された、1男児例 Basic Life SupportのAEDによる再評価と有用性について
    福原 進一, 城本 高志, 野口 基視, 松原 優里, 高里 良宏, 佐藤 武志, 小島 拓朗, 高橋 努, 上山 泰淳, 井原 正博  日本小児科学会雑誌  112-  (7)  1150  -1150  2008/07  [Not refereed][Not invited]
  • 先天性ネフローゼ症候群の1例
    佐藤 武志, 野口 基視, 松原 優里, 高里 良宏, 小島 拓朗, 高橋 努, 上山 泰淳, 井原 正博  日本小児科学会雑誌  112-  (3)  535  -535  2008/03  [Not refereed][Not invited]
  • 当院における心臓腫瘍を合併した結節性硬化症のまとめ
    松原 優里, 野口 基視, 高里 良宏, 佐藤 武志, 小島 拓朗, 上山 泰淳, 高橋 努, 井原 正博  日本小児科学会雑誌  112-  (3)  536  -536  2008/03  [Not refereed][Not invited]
  • 多発動脈瘤、縦隔血腫食道穿破
    三橋 一輝, 保田 宏明, 和田 貴子, 真崎 武, 松原 優里, 戸川 啓史  京都府立与謝の海病院誌  5-  (1)  135  -135  2008/03  [Not refereed][Not invited]
  • 胸骨骨髄炎の1男児例
    佐藤 武志, 松原 優里, 高里 良宏, 児島 克明, 小島 拓朗, 高橋 努, 上山 泰淳, 井原 正博  日本小児科学会雑誌  112-  (1)  84  -84  2008/01  [Not refereed][Not invited]
  • 股関節炎を合併した川崎病γグロブリン不応例の2例
    児島 克明, 松原 優里, 高里 良宏, 佐藤 武志, 小島 拓朗, 高橋 努, 上山 泰淳, 井原 正博  日本小児科学会雑誌  112-  (1)  85  -85  2008/01  [Not refereed][Not invited]


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