shibayama naoya

FacultyPhysiologyMolecularPhysiology&Biophysics
Job titleProfessorWeb site

Profile

Research Keywords

    Allostery, Hemoglobin, Biological clock, EA4, Sol-gel

Research Areas

  • Biological science / Structural biochemistry
  • Biological science / Biophysics

Career

  • Jichi Medical University, Lecturer

Academic Background

  • -
    1985
    Graduate School, Division of Engineering Science, Osaka University (japan)
  • -
    1983
    Faculty of Engineering Science, Osaka University (japan)

Research Activities

Papers(paper)

  • Capturing the hemoglobin allosteric transition in a single crystal form.
    Shibayama N, Sugiyama K, Tame JR, Park SY
    Journal of the American Chemical Society 136 5097-5105 Apr. 2014
  • Intersubunit communication via changes in hemoglobin quaternary structures revealed by time-resolved resonance Raman spectroscopy: direct observation of the Perutz mechanism.
    Yamada K, Ishikawa H, Mizuno M, Shibayama N, Mizutani Y
    The journal of physical chemistry. B 117 12461-12468 Oct. 2013
  • Homopiperazine derivatives as a novel class of proteasome inhibitors with a unique mode of proteasome binding.
    Kikuchi J, Shibayama N, Yamada S, Wada T, Nobuyoshi M, Izumi T, Akutsu M, Kano Y, Sugiyama K, Ohki M, Park SY, Furukawa Y
    PloS one 8 e60649 2013
  • Symmetry distortion in the human hemoglobin tetramer induced by asymmetric ligation.
    Shibayama N
    FEBS letters 586 74-78 Jan. 2012
  • Structures and oxygen affinities of crystalline human hemoglobin C (β6 Glu->Lys) in the R and R2 quaternary structures.
    Shibayama N, Sugiyama K, Park SY
    The Journal of biological chemistry 286 33661-33668 Sep. 2011
  • MWC2状態モデルはヘモグロビンのアロステリーといかに調和しうるか
    柴山修哉
    人工血液 18(3) 102-109 Jan. 2011
  • Protonation states of histidine and other key residues in deoxy normal human adult hemoglobin by neutron protein crystallography.
    Kovalevsky A, Chatake T, Shibayama N, Park SY, Ishikawa T, Mustyakimov M, Fisher SZ, Langan P, Morimoto Y
    Acta crystallographica. Section D, Biological crystallography 66 1144-1152 Nov. 2010
  • Direct determination of protonation states of histidine residues in a 2 A neutron structure of deoxy-human normal adult hemoglobin and implications for the Bohr effect.
    Kovalevsky AY, Chatake T, Shibayama N, Park SY, Ishikawa T, Mustyakimov M, Fisher Z, Langan P, Morimoto Y
    Journal of molecular biology 398 276-291 Apr. 2010
  • Physicochemical properties of diheme cytochrome c4 of unknown function from Vibrio parahaemolyticus strain RIMD2210633.
    Akazaki H, Futami Y, Shibayama N, Shirasaki I, Nakade H, Chida H, Hakamata W, Park SY, Nishio T, Oku T
    Bioscience, biotechnology, and biochemistry 72 2791-2794 Oct. 2008
  • The structural basis for an essential subunit interaction in influenza virus RNA polymerase.
    Obayashi E, Yoshida H, Kawai F, Shibayama N, Kawaguchi A, Nagata K, Tame JR, Park SY
    Nature 454 1127-1131 Aug. 2008
Display all
Papers(paper)close
  • Capturing the hemoglobin allosteric transition in a single crystal form.
    Shibayama N, Sugiyama K, Tame JR, Park SY
    Journal of the American Chemical Society 136 5097-5105 Apr. 2014
  • Intersubunit communication via changes in hemoglobin quaternary structures revealed by time-resolved resonance Raman spectroscopy: direct observation of the Perutz mechanism.
    Yamada K, Ishikawa H, Mizuno M, Shibayama N, Mizutani Y
    The journal of physical chemistry. B 117 12461-12468 Oct. 2013
  • Homopiperazine derivatives as a novel class of proteasome inhibitors with a unique mode of proteasome binding.
    Kikuchi J, Shibayama N, Yamada S, Wada T, Nobuyoshi M, Izumi T, Akutsu M, Kano Y, Sugiyama K, Ohki M, Park SY, Furukawa Y
    PloS one 8 e60649 2013
  • Symmetry distortion in the human hemoglobin tetramer induced by asymmetric ligation.
    Shibayama N
    FEBS letters 586 74-78 Jan. 2012
  • Structures and oxygen affinities of crystalline human hemoglobin C (β6 Glu->Lys) in the R and R2 quaternary structures.
    Shibayama N, Sugiyama K, Park SY
    The Journal of biological chemistry 286 33661-33668 Sep. 2011
  • MWC2状態モデルはヘモグロビンのアロステリーといかに調和しうるか
    柴山修哉
    人工血液 18(3) 102-109 Jan. 2011
  • Protonation states of histidine and other key residues in deoxy normal human adult hemoglobin by neutron protein crystallography.
    Kovalevsky A, Chatake T, Shibayama N, Park SY, Ishikawa T, Mustyakimov M, Fisher SZ, Langan P, Morimoto Y
    Acta crystallographica. Section D, Biological crystallography 66 1144-1152 Nov. 2010
  • Direct determination of protonation states of histidine residues in a 2 A neutron structure of deoxy-human normal adult hemoglobin and implications for the Bohr effect.
    Kovalevsky AY, Chatake T, Shibayama N, Park SY, Ishikawa T, Mustyakimov M, Fisher Z, Langan P, Morimoto Y
    Journal of molecular biology 398 276-291 Apr. 2010
  • Physicochemical properties of diheme cytochrome c4 of unknown function from Vibrio parahaemolyticus strain RIMD2210633.
    Akazaki H, Futami Y, Shibayama N, Shirasaki I, Nakade H, Chida H, Hakamata W, Park SY, Nishio T, Oku T
    Bioscience, biotechnology, and biochemistry 72 2791-2794 Oct. 2008
  • The structural basis for an essential subunit interaction in influenza virus RNA polymerase.
    Obayashi E, Yoshida H, Kawai F, Shibayama N, Kawaguchi A, Nagata K, Tame JR, Park SY
    Nature 454 1127-1131 Aug. 2008
  • Circular dichroism study on the early folding events of beta-lactoglobulin entrapped in wet silica gels.
    Shibayama N
    FEBS letters 582 2668-2672 Jul. 2008
  • Slow motion analysis of protein folding intermediates within wet silica gels.
    Shibayama N
    Biochemistry 47 5784-5794 May 2008
  • Crystal structures of the clock protein EA4 from the silkworm Bombyx mori.
    Hiraki T, Shibayama N, Akashi S, Park SY
    Journal of molecular biology 377 630-635 Mar. 2008
  • Protonation states of buried histidine residues in human deoxyhemoglobin revealed by neutron crystallography.
    Chatake T, Shibayama N, Park SY, Kurihara K, Tamada T, Tanaka I, Niimura N, Kuroki R, Morimoto Y
    Journal of the American Chemical Society 129 14840-14841 Dec. 2007
  • Crystallization and preliminary crystallographic studies of the metalloglycoprotein esterase A4 using a baculovirus expression system.
    Hiraki T, Shibayama N, Yoon YH, Yun KM, Hamamoto T, Tame JR, Park SY
    Acta crystallographica. Section F, Structural biology and crystallization communications 63 734-736 Sep. 2007
  • 1.25 A resolution crystal structures of human haemoglobin in the oxy, deoxy and carbonmonoxy forms.
    Park SY, Yokoyama T, Shibayama N, Shiro Y, Tame JR
    Journal of molecular biology 360 690-701 Jul. 2006
  • Crystal structures of unliganded and half-liganded human hemoglobin derivatives cross-linked between Lys 82beta1 and Lys 82beta2.
    Park SY, Shibayama N, Hiraki T, Tame JR
    Biochemistry 43 8711-8717 Jul. 2004
  • Watching the Photolysis-Induced Structural Changes in Hemoglobin
    SHIBAYAMA Naoya
    Biophysics 44(3) 108-112 2004
  • Highly nonexponential kinetics in the early-phase refolding of proteins at low temperatures.
    Saigo S, Shibayama N
    Biochemistry 42 9669-9676 Aug. 2003
  • Direct observation of photolysis-induced tertiary structural changes in hemoglobin.
    Adachi S, Park SY, Tame JR, Shiro Y, Shibayama N
    Proceedings of the National Academy of Sciences of the United States of America 100 7039-7044 Jun. 2003
  • Oxygen equilibrium properties of myoglobin locked in the liganded and unliganded conformations.
    Shibayama N, Saigo S
    Journal of the American Chemical Society 125 3780-3783 Apr. 2003
  • Crystal structure of horse carbonmonoxyhemoglobin-bezafibrate complex at 1.55-A resolution. A novel allosteric binding site in R-state hemoglobin.
    Shibayama N, Miura S, Tame JR, Yonetani T, Park SY
    The Journal of biological chemistry 277 38791-38796 Oct. 2002
  • The contribution of the asymmetric alpha 1beta 1 half-oxygenated intermediate to human hemoglobin cooperativity.
    Yun KM, Morimoto H, Shibayama N
    The Journal of biological chemistry 277 1878-1883 Jan. 2002
  • Trapping of Conformational States of Proteins Using a Sol-Gel Method
    SHIBAYAMA Naoya
    Biophysics 40(5) 346-349 2000
  • The Law of Action and Reaction is Misunderstood.
    AONO OSAMU, SAIGO SATOSHI, HARADA MITSUO, SHIBAYAMA NAOYA
    物理教育 45(6) 328-329 Dec. 1997
  • Forum on University Physics Education in Medical, Dental and Pharmaceutical Schools. New Curriculum of Physics in the Jichi Medical School.
    AONO OSAMU, SAIGO SATOSHI, HARADA MITSUO, SHIBAYAMA NAOYA
    物理教育 42(3) 307-310 Sep. 1994

Papers(other)

  • Oxygen equilibrium study and light absorption spectra of NI(II)-Fe(II) hybrid hemoglobins.
    Journal of Molecular Biology 192, 323-329 1986
  • Properties of chemically modified Ni(II)-Fe(II) hybrid hemoglobins.
    Journal of Molecular Biology 192, 330-336 1986
  • Oxygen equilibrium properties of highly purified human adult hemoglobin cross-linked between 82 β1 and 82 β2 lysyl residues by bis (3,5-dibromosalicyl) fumarate.
    Biochemistry 30, 8158-8165 1991
  • Structure of deoxy-quaternary haemoglobin with liganded β subunits (共著)
    Journal of Molecular Biology 214, 7-14 1990
  • Structure of haemoglobin in the deoxy quaternary state with ligand bound at the haems α (共著)
    Journal of Molecular Biology 206, 723-736 1989
  • Polymerization and solubility of Ni(II)-Fe(II) hybid HbS. (共著)
    Biochimicu et Biophysica Acta 1079, 268-272 1991
  • Proton nuclear magnetic resonance and spectrophotometric sturides of nickel(II)-iron(II) hybrid hemoglobins.
    Biochemistry 26, 2194-2201 1987
  • Polymerization of partially liganded hemoglobin S. (共著)
    Sickle Cell Disease 565, 356-357 1989
  • Oxygen Equilibriun Properties of Asymmetric Nickel(II)-Iron(II) Hybrid Hemoglobin
    Biochemistry 32,8792-8798 1993
  • Oxygen Eguilibrium Properties of Nickel(II)-Iron(II)Hybrid Hemoglobins Cross-linked between 82β1 and 82β2 Lysyl Residues by Bis(3, 5-dibromosalicyl)-fumarte : Determination of the First Two-Step Microscopic Adair Constants for Human Hemoglobin
    Biochemistry 34, 4773-4780 1995
Display all
Papers(other)close
  • Oxygen equilibrium study and light absorption spectra of NI(II)-Fe(II) hybrid hemoglobins.
    Journal of Molecular Biology 192, 323-329 1986
  • Properties of chemically modified Ni(II)-Fe(II) hybrid hemoglobins.
    Journal of Molecular Biology 192, 330-336 1986
  • Oxygen equilibrium properties of highly purified human adult hemoglobin cross-linked between 82 β1 and 82 β2 lysyl residues by bis (3,5-dibromosalicyl) fumarate.
    Biochemistry 30, 8158-8165 1991
  • Structure of deoxy-quaternary haemoglobin with liganded β subunits (共著)
    Journal of Molecular Biology 214, 7-14 1990
  • Structure of haemoglobin in the deoxy quaternary state with ligand bound at the haems α (共著)
    Journal of Molecular Biology 206, 723-736 1989
  • Polymerization and solubility of Ni(II)-Fe(II) hybid HbS. (共著)
    Biochimicu et Biophysica Acta 1079, 268-272 1991
  • Proton nuclear magnetic resonance and spectrophotometric sturides of nickel(II)-iron(II) hybrid hemoglobins.
    Biochemistry 26, 2194-2201 1987
  • Polymerization of partially liganded hemoglobin S. (共著)
    Sickle Cell Disease 565, 356-357 1989
  • Oxygen Equilibriun Properties of Asymmetric Nickel(II)-Iron(II) Hybrid Hemoglobin
    Biochemistry 32,8792-8798 1993
  • Oxygen Eguilibrium Properties of Nickel(II)-Iron(II)Hybrid Hemoglobins Cross-linked between 82β1 and 82β2 Lysyl Residues by Bis(3, 5-dibromosalicyl)-fumarte : Determination of the First Two-Step Microscopic Adair Constants for Human Hemoglobin
    Biochemistry 34, 4773-4780 1995
  • Oxygen equilibriun and electron paramagnetic resonance studies on copper(II)-iron(II) hybrid hemoglobins at room temperature.
    FEBS Letters 372, 126-130 1995
  • Fixation of the quaternary strnctures of hyman adult haemoglobin by encapsnlation in transparent porons silica gels.
    Journal of Molecnlar Biology 251, 203-209 1995
  • Mechanism of ligand binding to Ni(II)-Fe(II) hybrid hemoglobins.
    Biochemistry 34, 14658-14667 1995
  • Oxygen equilibrium properties of chromium(III)-iron(II)hybrid hemoglobins (共著)
    Journal of Biological Chemistry 271, 12451-12456 1996
  • Reexamination of the hyperthermodynamic stability of asymmetric cyanomet valency hybrid hemoglobin, (α+CN-β+CN-)(αβ) : No preferentially populating asymmetric hybrid at equilibrium
    Biochemistry 36, 4375-4381 1997
  • Asymmetric cyanomet valency hybrid hemoglobin, (α+CN-β+CN-)(αβ) : The issue of valency exchange.
    Biochemistry 3718, 6221-6228 1998
  • Rate constants for O2and CO binding to the alpha and beta subunits within the R and T states of human hemoglobin(共著)
    Journal of Biological Chemistry 273, 23150-23159 1998
  • Kinetics of the allosteric transition in hemoglobin within silicate sol-gels
    Journal of the American Chemical Society 121, 444-445 1999
  • Functional analysis of hemoglobin molecules locked in doubly liganded conformations
    Journal of Molecular Biology 285, 1383-1388 1999
  • Magnesium (Ⅱ)and zinc(Ⅱ)-prptoporphyrin (Ⅸ)'s stabilige the lowest oxygen affinity state of human hemoglobin even more strongly than deoxyheme(共著)
    Journal of Molecular Biology 292, 1121-1136 1999
  • Direct observation of two distinct affinity conformations in the T state human deoxyhemoglobin
    FEBS Letters 492, 50-53 2001
  • The Contribntion of the Asymmetric α1β1 Half-oxygenated Intermediate to Human Hemoglobin Cooperativity(共著
    Journal of Biological Chemistry 277, 1878-1883 2002
  • Crystal Strnctnre of Horse Carbonmonoxy hemoglobin-Bezafibrate Complex at 1.55-A resolution
    Journal of Biological Chemistry 277, 38791-38796 2002
  • Differences in changes of the α1β2 subnnit contacts between Ligand Binding to the α and β subnnits of Hemoglobin A(共著)
    Biochemistry 41, 10010-10020 2002
  • Direct observation of photolysis-induced tertiary structural changes in hemoglobin
    Proceedings of the National Academy of Sciences of the United States of America 100, 7039-7044 2003
  • Oxygen Eguilibrium Properties of Myoglobin Locked in the Liganded and Unliganded Conformations
    Journal of the American Chemical Society 125, 3780-3783 2003
  • Highly Nonexponential Kinetics in the Early-Phase Refolding of Proteins at Low Temperatures
    Biochemistry 42, 9669-9676 2003
  • Crystal Structures of Unliganded and Half-Liganded Human Hemoglobin Derivatives Cross-Linked between Lys82β1 and Lys82β2
    Biochemistry 43, 8711-8717 2004

Conference Presentations

  • Slow Ligand Migration Dynamics in Tetramerio Hemoglobin at Cryogenic Temperature
    TOMITA AYANA, SATO ATSUSHI, NOZAWA SHUNSUKE, HOSHINO MANABU, NOGUCHI HIROTAKA, BOKU SAN'YO, SHIBAYAMA NAOYA, KOSHIHARA SHIN'YA, ADACHI SHIN'ICHI, ADACHI SHIN'ICHI
    物構研サイエンスフェスタ要旨集 2013
  • セルフタイマーを内蔵するタンパク質EA4
    柴山修哉
    日本蛋白質科学会年会プログラム・要旨集 31 May 2012
  • 3SA4-05 The true nature of the allosteric equilibrium of hemoglobin(3SA4 Hemoglobin revisited,The 47th Annual Meeting of the Biophysical Society of Japan)
    Shibayama Naoya
    Biophysics 20 Sep. 2009
  • Vibrio parahaemolyticus由来機能未知c4‐type cytochromeの大腸菌での大量発現,精製と物理化学的性質の決定
    小嶋翔平, 赤崎秀治, 柴山修哉, 関根晃陽, 比留間航, 山本慎一郎, 袴田航, 朴三用, 西尾俊幸, 奥忠武
    日本農芸化学会大会講演要旨集 05 Mar. 2009
  • パルス中性子源を用いたヒト由来デオキシヘモグロビンの中性子実験
    茶竹俊行, 石川卓哉, KOVALEVSKYI Andrii Y., 柴山修哉, PARK Sam‐Yong, MUSTYAKIMOV Marat, LANGAN Paul, 森本幸生
    京都大学原子炉実験所学術講演会報文集 Jan. 2008
  • 1P016 EA4 is a protein with a built-in self-timer(Proteins-structure and structure-function relationship,Oral Presentations)
    Shibayama Naoya, Hiraki Toshiki, Akashi Satoko, Tame Jeremy R. H., Park Sam-Yong
    Biophysics 20 Nov. 2007
  • デオキシヘモグロビンの中性子構造の精密化により明らかにされた,ヒスチジン残基のプロトネーション
    茶竹俊行, PARK Sam‐Yong, 柴山修哉, 森本幸生
    日本中性子科学会年会講演概要集 2006
  • 3P042 Protein folding monitored by slow motion
    Shibayama N.
    Biophysics 19 Oct. 2005
  • 1P018 Crystal structure of esterase A4 that acts alone as a molecular clock
    Hiraki T., Shibayama N., Tame Jeremy R.H., Park S.-Y.
    Biophysics 19 Oct. 2005
  • 3P018 Slow motion analysis of cytochrome c folding dynamics using a porous sol-gel
    Shibayama N.
    Biophysics 10 Nov. 2004
Display all
Conference Presentationsclose
  • Slow Ligand Migration Dynamics in Tetramerio Hemoglobin at Cryogenic Temperature
    TOMITA AYANA, SATO ATSUSHI, NOZAWA SHUNSUKE, HOSHINO MANABU, NOGUCHI HIROTAKA, BOKU SAN'YO, SHIBAYAMA NAOYA, KOSHIHARA SHIN'YA, ADACHI SHIN'ICHI, ADACHI SHIN'ICHI
    物構研サイエンスフェスタ要旨集 2013
  • セルフタイマーを内蔵するタンパク質EA4
    柴山修哉
    日本蛋白質科学会年会プログラム・要旨集 31 May 2012
  • 3SA4-05 The true nature of the allosteric equilibrium of hemoglobin(3SA4 Hemoglobin revisited,The 47th Annual Meeting of the Biophysical Society of Japan)
    Shibayama Naoya
    Biophysics 20 Sep. 2009
  • Vibrio parahaemolyticus由来機能未知c4‐type cytochromeの大腸菌での大量発現,精製と物理化学的性質の決定
    小嶋翔平, 赤崎秀治, 柴山修哉, 関根晃陽, 比留間航, 山本慎一郎, 袴田航, 朴三用, 西尾俊幸, 奥忠武
    日本農芸化学会大会講演要旨集 05 Mar. 2009
  • パルス中性子源を用いたヒト由来デオキシヘモグロビンの中性子実験
    茶竹俊行, 石川卓哉, KOVALEVSKYI Andrii Y., 柴山修哉, PARK Sam‐Yong, MUSTYAKIMOV Marat, LANGAN Paul, 森本幸生
    京都大学原子炉実験所学術講演会報文集 Jan. 2008
  • 1P016 EA4 is a protein with a built-in self-timer(Proteins-structure and structure-function relationship,Oral Presentations)
    Shibayama Naoya, Hiraki Toshiki, Akashi Satoko, Tame Jeremy R. H., Park Sam-Yong
    Biophysics 20 Nov. 2007
  • デオキシヘモグロビンの中性子構造の精密化により明らかにされた,ヒスチジン残基のプロトネーション
    茶竹俊行, PARK Sam‐Yong, 柴山修哉, 森本幸生
    日本中性子科学会年会講演概要集 2006
  • 3P042 Protein folding monitored by slow motion
    Shibayama N.
    Biophysics 19 Oct. 2005
  • 1P018 Crystal structure of esterase A4 that acts alone as a molecular clock
    Hiraki T., Shibayama N., Tame Jeremy R.H., Park S.-Y.
    Biophysics 19 Oct. 2005
  • 3P018 Slow motion analysis of cytochrome c folding dynamics using a porous sol-gel
    Shibayama N.
    Biophysics 10 Nov. 2004
  • 2P006 Neutron Structure analysis of Human Hemoglobin
    Morimoto Y., Park S.Y., Shibayama N., Kurihara K., Tanaka I., Tamada T., Kuroki R., Niimura N.
    Biophysics 10 Nov. 2004
  • 3SB04 Direct observation of photolysis-induced structural changes in hemoglobin
    Adachi S., Shiro Y., Park S.-Y., Tame Jeremy R. H., Shibayama N.
    Biophysics 10 Nov. 2004
  • ヒトヘモグロビンの中性子回折による構造研究
    森本幸生, PARK S. Y., 柴山修哉, 栗原和男, 田中伊知朗, 玉田太郎, 黒木良太, 新村信雄
    日本中性子科学会年会講演概要集 2004
  • X線回折法によるタンパク質の光誘起反応中間体構造解析~ヒトヘモグロビンにおける光誘起構造変化の直接観測~
    足立伸一, 城宜嗣, PARK S‐Y, TAME J R H, 柴山修哉
    SPring-8利用者情報 16 Nov. 2003
  • Trapping of the submillisecond folding intermediates of cytochrome c in a wet porous sol-gel silica
    Shibayama N., Saigo S.
    Biophysics 25 Aug. 2003
  • ゾル・ゲル法でミオグロビン分子のコンホメーションを固定する
    柴山修哉
    日本生物物理学会年会講演予稿集 Nov. 2002
  • 2J1630 Crystal sturcture of photolysed intermediates of T- and R-state lmman carbonmonoxy heamoglobin at 25 K
    Adachi S., Park S. -Y., Tame Jeremy, Shiro Y., Shibayama N.
    Biophysics 10 Oct. 2002
  • 2K1645 Sol-gel trapping of the conformations of myoglobin
    Shibayama N.
    Biophysics 10 Oct. 2002
  • 薬剤結合でヘモグロビンのR状態の酸素親和性を変えることができる
    柴山修哉, TAME J, 米谷隆, PARK S‐Y
    日本生物物理学会年会講演予稿集 Oct. 2001
  • Oxygen affinity of R-state hemoglobin can be altered by drug binding
    Shibayama N., Tame Jeremy, Yonetani T., Park S.-Y.
    Biophysics 10 Sep. 2001
  • Structures and stabilities of interspecies chimeric cytochromes c
    Yamamoto E., Shibayama N., Saigo S.
    Biophysics 10 Sep. 2001
  • Structural stability of interspecies hybrid cytochrome c
    Yamamoto E., Shibayama N., Saigo S.
    Biophysics 05 Aug. 2000
  • Sol-gel trapping of the conformations of the annelid giant hemoglobin
    Shibayama N., Imai K., Gotoh T.
    Biophysics 05 Aug. 2000
  • An O_2-jump stopped-flow method to determine oxygen equilibrium properties of asymmetric Zn-Fe hybrid hemoglobin
    Yun K-M., Miyazaki G., Takahashi S., Morishima I., Shibayama N., Saigo S., Morimoto H.
    Biophysics 05 Aug. 2000
  • Secondary-structure formation during the refolding of cytochrome c : A low-temperature stopped-flow study
    Saigo S., Shibayama N., Yamamoto E.
    Biophysics 05 Aug. 2000
  • Difference in contribution between .ALPHA.-chain and .BETA.-chain in the quatenary structural change of Hemoglobin: Studies of Ni-Fe Hybrid Hemoglobin and Hb M(Iwate,Boston,Milwaukee).
    NAGATOMO SHIGENORI, NAGAI MASAKO, SHIBAYAMA NAOYA, KITAGAWA TEIZO
    生体分子科学討論会講演要旨集 Aug. 2000
  • An O_2-jump stopped-flow method to determine oxygen equilibrium curves of Hb : application to asymmetric Zn-Fe hybrid Hb(s)
    Yun K. M., Morimoto H., Hori H., Saigo S., Shibayama N.
    Biophysics 02 Sep. 1999
  • Structural stability of semisynthetic horse heart cytochrome c
    Yamaoto E., Shibayama N., Saigo S.
    Biophysics 02 Sep. 1999
  • Sol-gel-encapsulation of hemoglobin.
    Shibayama N.
    Biophysics 02 Sep. 1999
  • 半合成ウマ心筋シトクロムcの立体構造安定性
    山本栄治, 柴山修哉, 西郷敏
    日本生物物理学会年会講演予稿集 02 Sep. 1999
  • 酸素濃度ジャンプ・ストップトフロー法を用いたヘモグロビンの酸素平衡曲線の測定 非対称Zn‐Fe混成Hbへの応用
    YUN K M, 森本英樹, 堀洋, 西郷敏, 柴山修哉
    日本生物物理学会年会講演予稿集 02 Sep. 1999
  • Protein Structure and Metal Coordination and Their Functional Relations of Ni-Fe Hybrid Hb Studied with UVRR.
    Nagatomo S., Nagai M., Shibayama N., Kitagawa T.
    Biophysics 07 Sep. 1998
  • 低温におけるタンパク質の折れたたみの初期過程
    西郷敏, 柴山修哉, 山本栄治, 高嶋真純
    日本生物物理学会年会講演予稿集 Sep. 1998
  • 3Q01 Rate constants for O_2 and CO binding to metal-Fe(II) hydrid Hbs.
    Unzai S., Eich R., Shibayama N., Olson J.S., Morimoto H.
    Biophysics 05 Sep. 1997
  • Metallic substitution hybrid hemoglobin. (Ministry of Education S)
    IN KEIMOKU, UNZAI SATORU, MIYAZAKI GENTARO, MORIMOTO HIDEKI, SHIBAYAMA SHUYA
    酸素結合蛋白質の分子操作と精密構造機能研究の新展開 平成7-8年度 No.07308071 1997
  • 多孔性ガラスで高次構造を固定したヘモグロビンの機能
    柴山修哉
    日本生物物理学会年会講演予稿集 Oct. 1996
  • Structure analysis of the reaction intermediate of carboxypeptidase A in the vicinity of its metal center.
    SAIGO SATOSHI, SHIBAYAMA NOBUYA, KOZUTSUMI KAZUHIKO, YOKOYAMA TOSHIHIKO
    日本生物物理学会年会講演予稿集 Aug. 1995
  • SANS Study of Gels prepared from Si(OCH_3)_4
    Harada M., Shibayama N.
    Abstracts of the meeting of the Physical Society of Japan. Annual meeting 16 Mar. 1995
  • Time-resolved EXAFS spectroscopy of proteins.
    SAIGO SATOSHI, SHIBAYAMA NOBUYA, OZUTSUMI KAZUHIKO, YOKOYAMA TOSHIHIKO
    日本生物物理学会年会講演予稿集 Sep. 1994
  • Difference between .ALPHA.-substituted and .BETA.-substituted metal-ferrous hybrid Hbs.
    UNZAI SATORU, MORIMOTO HIDEKI, SHIBAYAMA NOBUYA
    日本生物物理学会年会講演予稿集 Sep. 1994
  • Fixation of quaternary structures of hemoglobin by porous silicate glasses.
    SHIBAYAMA NOBUYA, SAIGO SATOSHI, OSUMI TOMONORI, MORIMOTO HIDEKI
    日本生物物理学会年会講演予稿集 Sep. 1994
  • Oxygen equilibrium properties of closs-linked Cr(III)-Fe(II) Hybrid Hemoglobins.
    雲財悟, 堀洋, 宮崎源太郎, 森本英樹, 柴山修哉
    日本生物物理学会年会講演予稿集 Sep. 1993
  • β鎖間を架橋したNi(II)‐Fe(II)混成ヘモグロビンの酸素平衡機能
    柴山修哉, 今井清博, 西郷敏, 森本英樹
    日本生物物理学会年会講演予稿集 Oct. 1992

Outside Fund Adoption

  • Slow motion analysis of the fokling reactions of proteins within wet silica gels
    Ministry of Education, Culture, Sports, Science and Technology:Grants-in-Aid for Scientific Research(基盤研究(C))
    Project Year :2005 - 2007 Investigator(s) : Naoya SHIBAYAMA
  • Study on the allosteric mechanism of hemoglobin.
    Project Year :1983
  • Study on the timer mechanism of the clock protein EA4
    Project Year :2001
  • Slow motion analysis of protein dynamics within wet silica gels
    Project Year :1995
Display all
Outside Fund Adoptionclose
  • Slow motion analysis of the fokling reactions of proteins within wet silica gels
    Ministry of Education, Culture, Sports, Science and Technology:Grants-in-Aid for Scientific Research(基盤研究(C))
    Project Year :2005 - 2007 Investigator(s) : Naoya SHIBAYAMA
  • Study on the allosteric mechanism of hemoglobin.
    Project Year :1983
  • Study on the timer mechanism of the clock protein EA4
    Project Year :2001
  • Slow motion analysis of protein dynamics within wet silica gels
    Project Year :1995


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