Researchers Database


    ClinicalLaboratoryMedicine Professor
Last Updated :2021/11/23

Researcher Information


  • Ultrasonic tissue characterization(Jichi Medical University)

J-Global ID

Research Interests

  • 超音波診断   Ultrasonic Diagnosis   

Research Areas

  • Life sciences / Biomaterials
  • Life sciences / Biomedical engineering

Association Memberships

  • 日本乳腺甲状腺超音波診断会議   日本脳神経超音波学会   日本消化器集検学会   日本臨床検査医学会   日本消化器病学会   日本内科学会   日本超音波医学会   Japan Society of ultrasound in Medicine   

Books etc

  • Comnparison of platelet activation and hepatic cell damage of rats induced by two ultrasound contrast agents
    International congress series 2004


  • 中国における肝癌のhigh risk groupを対象とした超音波検診


  • Tomoyuki Kuwata, Shigeki Matsubara, Nobuyuki Taniguchi, Akihide Ohkuchi, Takashi Ohkusa, Mitsuaki Suzuki  JOURNAL OF PERINATAL MEDICINE  38-  (5)  491  -494  2010/09  [Not refereed][Not invited]
    Aims: To evaluate uterine cervical consistency using a vaginal ultrasound gray-level histogram. Methods: Vaginal ultrasound and digital examination were performed for 214 women with low-risk singleton pregnancy during 27-30(th) pregnancy week. The mean gray-level (MGL) of an ultrasound gray-level histogram, representing the echogenicity of a region of interest, was measured in the midsection of anterior and posterior cervical walls. The difference in MGL between anterior and posterior (AP difference) was related to the Bishop sub-score for cervical consistency (0, 1, or 2), determined before ultrasound. Results: A larger positive AP difference indicated significantly lower Bishop sub-score. After analyzing the receiver operator characteristic curves for the AP difference, a value of 1.42 and -1.98 was the best cut-off value to determine a hard cervix (score 0) and a soft cervix (score 2), respectively. To identify a hard cervix, this test had 71% sensitivity and 82% specificity. For a soft cervix, it was 66% and 87%, respectively. Conclusions: A more echogenic anterior than posterior cervix indicates a hard cervix; the greater the difference in echogenicity between anterior and posterior walls the harder the cervix. The difference in MGL of the ultrasound gray-level histogram may enable objective evaluation of cervical consistency.
  • Harumi Koibuchi, Shunji Hayashi, Kazuhiko Kotani, Yasutomo Fujii, Kei Konno, Yoshikazu Hirai, Nobuyuki Taniguchi  JOURNAL OF MEDICAL ULTRASONICS  36-  (4)  187  -192  2009/12  [Not refereed][Not invited]
    To determine suitable methods for evaluating bacterial contamination of ultrasound probes. We compared probe imprinting, swab streaking, and swab suspension methods for evaluating bacterial contamination of ultrasound probes. Experimental and clinical investigations showed that the sensitivity for detecting bacterial contamination of ultrasound probes was higher with probe imprinting than with swab methods. Probe imprinting was very simple and required only agar plates. Probe imprinting was the most suitable method for evaluating bacterial contamination of ultrasound probes.
  • Kazuhiko Kotani, Harumi Koibuchi, Toshiyuki Yamada, Nobuyuki Taniguchi  CLINICA CHIMICA ACTA  409-  (1-2)  67  -69  2009/11  [Not refereed][Not invited]
    Background: Lifestyle modification improves the pathophysiology of lipid disorder, leading to the development of cardiovascular disease (CVD). While oxidized low-density lipoprotein (oxLDL) may. be involved in this mechanism, various oxLDL measurements have recently been developed and therefore further detailed studies are called for in this area. Our aim was to investigate the effects of lifestyle modification on serum amyloid A-LDL (SAA-LDL), a new oxLDL, in subjects with primary lipid disorder. Methods: A total of 141 asymptomatic subjects (women/men = 100/41, mean age 57.6 years) with >= 1 lipid abnormality (circulating high levels of low-density lipoprotein cholesterol [LDL-C] and triglyceride [TG] or low levels of high-density lipoprotein cholesterol [HDL-C]), who completed a 6-month lifestyle modification program in combination with diet and exercise, were analyzed. In the pre- and post-intervention, the metabolic variables including SAA-LDL were assessed. Results: During our intervention, the body mass index, blood pressure, LDL-C, TG, glucose and SAA-LDL significantly decreased, while HDL-C significantly increased. Multiple regression analysis revealed that the change levels of TG (positive) and HDL-C (inverse) were significantly and independently correlated to those of SAA-LDL. Conclusions: These results suggest that SAA-LDL may contribute to the link between lipid disorder and the development of CVD, and that the application of SAA-LDL measurements may be useful for the assessment of the risk of CVD as a biochemical marker. (C) 2009 Published by Elsevier B.V.
  • Shuumarjav Uurtuya, Kazuhiko Kotani, Nobuyuki Taniguchi, Hiroaki Matsunaga, Hiroshi Kanai, Hideyuki Hasegawa, Kazuomi Kario, Shun Ishibashi, Kouichi Itoh  JOURNAL OF MEDICAL ULTRASONICS  36-  (3)  129  -135  2009/09  [Not refereed][Not invited]
    A new method has been developed for evaluating arterial stiffness using transcutaneous and high-frequency ultrasound. There may be a difference in the clinical significance of peripheral arteries, such as the radial artery (a muscular property), and other medium/large-sized arteries (an elastic property). The aim of this study was to determine the relationship between upper limb peripheral arterial stiffness (ULPAS) using the new method for the radial artery and atherosclerotic parameters in comparison with carotid intima-media thickness (IMT) and cardio-ankle vascular index (CAVI) in a healthy population and a diseased population with hypertension (HT) and diabetes mellitus (DM). Forty-four apparently healthy individuals (mean age = 26.3 years, men/women = 14/30), 45 patients with drug-treated HT (mean age = 55.3 years, men/women = 17/28), and 37 patients with drug-treated DM (mean age = 55.2 years, men/women = 21/16) were investigated. Body mass index, systolic blood pressure (SBP), diastolic blood pressure (DBP), CAVI, IMT, ultrasonographically measured ULPAS, blood lipid/glucose-related parameters, and C-reactive protein (CRP) were all determined. Among the healthy subjects, ULPAS showed a significantly positive correlation with SBP and CRP. ULPAS showed a different correlation pattern with atherosclerotic parameters from that of IMT and CAVI. The HT subjects had significantly higher ULPAS levels than those with DM. In this diseased population, ULPAS showed a significant positive correlation with SBP and DBP, as well as a significant negative correlation with glucose. These results suggest that ULPAS may provide new information in association with some atherosclerotic conditions as a unique index different from IMT and CAVI.
  • Kenichi Utano, Kiyoka Omoto, Harumi Koibuchi, Natsuki Take, Hiroaki Matsunaga, Nobuyuki Taniguchi  JOURNAL OF MEDICAL ULTRASONICS  36-  (3)  145  -148  2009/09  [Not refereed][Not invited]
    A 7-year-old female infant presented with an asymptomatic soft tissue mass in the right neck. The tumor was considered to be a benign one because it had a smooth margin and no change in its size was observed. Ultrasonography showed a 4.5-cm-diameter solid tumor with a smooth, well-defined border. Inside the tumor, flow signals were observed on color Doppler and there were numerous echogenic spots. Magnetic resonance imaging (MRI) examination showed findings consistent with an ectopic thymus, i.e., T1- and T2-weighted images showed thymus-like signals. The course of the case is being continuously followed.
  • Kiyoka Omoto, Hiroaki Matsunaga, Natsuki Take, Yasuo Hozumi, Megumi Takehara, Yawara Omoto, Mikio Shiozawa, Hirobumi Mizunuma, Hiroki Harashima, Nobuyuki Taniguchi, Mikihiko Kawano  ULTRASOUND IN MEDICINE AND BIOLOGY  35-  (8)  1249  -1256  2009/08  [Not refereed][Not invited]
    This study aimed to evaluate the usefulness of sentinel lymph node (SLN) detection in breast cancer using contrast-enhanced ultrasonography (CEUS) with subareolar Sonazoid injection. The subjects were 20 breast cancer patients. General anesthesia was induced and 2 mL of Sonazoid was injected subareolarly. After massage of the injection site, the axillary area was observed transdermally using coded phase inversion harmonic ultrasonography with mechanical indices of 0.15 to 0.19. When contrast-enhanced lymph nodes (LNs) were seen, they were defined as CE-SLN. Two other SLN detection methods, the gamma-probe-guided and dye-guided methods, were performed together. We evaluated the SLNs detected by each method to determine if they corresponded with each other and calculated the SLN detection rate. After the SLNs were resected, pathologic examinations were done. The SLN detection rate of the CEUS-guided method, the dye-guided method and the gamma-probe-guided method were 70%, 75% and 100%, respectively. There was no statistically significant difference in these rates between the CEUS-guided and dye-guided methods (p = 0.99) but the CEUS-guided method showed a significantly lower rate than the gamma-probe-guided method (p = 0.020), and dye-guided method also showed a significantly lower rate than they-probe-guided method (p = 0.047). The number of CE-SLNs was I or 2 (average 1.1) and each took 2 to 20 (average 5.3) min to detect. The CE-SLNs corresponded grossly with SLNs detected by the gamma-probe-guided and dye-guided methods. The pathologic results indicated no metastasis from the resected SLNs in 15 of 20 cases. However, the CEUS-guided method detected 12 cases of these 15 and CE-SLNs were detected in two of the remaining five metastasis cases. In summary, in breast cancer patients, after subareolar injection of Sonazoid, contrast-enhanced LNs were observed in real time with ultrasonography. In an initial clinical study of 20 cases, the detection rate of the CEUS-guided method was less than that of the gamma-probe-guided method. It is suggested that the CEUS-guided method using Sonazoid may, with some improvements, be a useful new modality for sentinel node identification. (E-mail: (C) 2009 World Federation for Ultrasound in Medicine & Biology.
  • Shuumarjav Uurtuya, Nobuyuki Taniguchi, Kazuhiko Kotani, Toshiyuki Yamada, Mikihiko Kawano, Nyamdavaa Khurelbaatar, Kouichi Itoh, Tserenkhuu Lkhagvasuren  HYPERTENSION RESEARCH  32-  (2)  140  -144  2009/02  [Not refereed][Not invited]
    Mongolian people have higher mortality and morbidity rates due to cardiovascular disease (CVD) than Japanese people. The cardio-ankle vascular index (CAVI) and ankle-brachial index (ABI) are both atherosclerosis-related indexes. Presently, there is no comparative information on CAVI and ABI among young subjects between Mongolian and Japanese people. A total of one hundred Mongolian (men: 39%, mean age: 20.9 +/- 2.2 years) and 115 Japanese volunteers (men: 39%, mean age: 22.0 +/- 1.8 years) were recruited from among university students. The body mass index (BMI), heart rate (HR), blood pressure (BP), CAVI, ABI, carotid intima-media thickness, blood total cholesterol (TC), glucose and C reactive protein levels were measured. The levels of BMI, HR and diastolic BP were significantly higher, and TC and glucose were significantly lower in the Mongolian subjects than in the Japanese subjects. The CAVI values (median (interquartile range): 6.5 (5.8-7.0) vs. 5.6 (5.2-6.0)) and ABI (1.11 (1.05-1.17) vs. 1.09 (1.05-1.15)) were significantly higher in the Mongolian subjects than in the Japanese subjects. The patterns of correlation between CAVI, ABI and other atherosclerotic parameters were different: in age-, gender- and BMI-adjustment correlation tests for CAVI and ABI, HR (r=-0.25 for CAVI and ABI) showed a correlation in the Mongolian subjects, and for ABI systolic BP (r=-0.28) showed a correlation in the Japanese subjects. These results suggest that Mongolian subjects may be at higher risk of CVD, even among younger individuals, than Japanese subjects.
  • Harurni Koibuchi, Yasutomo Fujii, Nobuyuki Taniguchi  JOURNAL OF CLINICAL ULTRASOUND  36-  (6)  369  -370  2008/07  [Not refereed][Not invited]
    Glomus tumors are benign tumors that originate in a neuromyoarterial glomus body and most commonly occur in the subungual regions. We present an unusual case of a glomus tumor in a subcutaneous vein of the dorsum of the wrist in a 65-year-old man and describe its gray-scale and power Doppler sonographic appearance, with a brief discussion of the clinical and histologic findings. (C) 2008 Wiley Periodicals, Inc.
  • Yi Wang, Yong Wang, Yida Wang, Nobuyuki Taniguchi, Xian-Cheng Chen  JOURNAL OF NEUROSURGERY  107-  (5)  959  -964  2007/11  [Not refereed][Not invited]
    Object. The goal of this study was to combine the use of ultrasound contrast agents with intraoperative ultrasound techniques to identify intraoperatively a patient's vascular anatomy, including feeding arteries and draining veins of an intracranial arteriovenous malformation (AVM). Methods. The authors examined 12 consecutive patients with AVMs that had been diagnosed on the basis of preoperative findings on magnetic resonance images and digital subtraction angiograms obtained between September 2003 and December 2005. After each patient had undergone a routine craniotomy, a bolus of contrast agent was injected intravenously, and a real-time microbubble perfusion process was observed to identify the feeding arteries and draining veins of the AVM in a single cross-section. The so-called burst-refill technique was used to sweep the lesion in multiple sections and orientations to obtain information on the surrounding vascular anatomy, after which the findings were compared with those obtained during preoperative imaging. Results. Intraoperative ultrasonography provided high-quality images in every case. Although plain imaging failed to show an identifiable AVM boundary, color Doppler flow imaging clearly delineated the shape and margin of the AVM. Nevertheless, neither mode of imaging enabled the surgeons to categorically distinguish between feeding and draining vessels. The real-time perfusion process of microbubbles was first visualized 20 to 30 seconds after the SonoVue bolus injection, and the burst-refill technique made possible identification of the vascular anatomy of malformation lesions in multiple planes. Conclusions. Using both an ultrasound contrast agent and the burst-refill technique provided a rapid, convenient, and precise way of locating AVM feeding arteries intraoperatively. The combined technique seems warranted in the intraoperative treatment of AVMs.
  • Kiyoka Omoto, Yasuo Hozumi, Yawara Omoto, Nobuyuki Taniguchi, Kouichi Itoh, Yasutomo Fujii, Hirobumi Mizunuma, Hideo Nagai  JOURNAL OF CLINICAL ULTRASOUND  34-  (7)  317  -326  2006/09  [Not refereed][Not invited]
    Purpose. To determine the clinical usefulness of a sentinel lymph node (SLN) identification technique using contrast-enhanced sonography (CEUS) with 25% albumin. Methods. The subjects were 23 women with breast cancer. Each was injected subcutaneously with 5 ml of 25% albumin solution as a negative contrast agent directly superficial to the breast tumor. The area was massaged, and the inferior axillary hairline was examined continuously using gray-scale sonography with a 7.5- or 10-MHz transducer. Any contrast-enhanced lymph node was considered a CEUS-detected SLN, was differentiated from other level I and II nodes, and was resected and pathologically assessed. Results. In all 23 patients, 1 or 2 CEUS-detected SLNs (mean, 1.3 SLNs) were identified. Their sizes ranged from 5 mm to 25 mm (mean, 11.3 mm), and their depths (from the skin surface) ranged from 5 mm to 20 mm (mean, 12.6 mm). Pathologic examination revealed a metastasis in 5 of the 23 patients, all in CEUS-detected SLNs. Conclusions. In a clinical study using CEUS with 25% albumin, contrast-enhanced nodes were identified in all subjects. The pathologic findings suggested that any metastatic nodes observed were SLNs, indicating that this technique may represent a new modality for SLN identification. (C) 2006 Wiley Periodicals, Inc.
  • Harumi Koibuchi, Yasutomo Fujii, Yoshihiro Kurosaki, Nobuyuki Taniguchi  Journal of Medical Ultrasonics  33-  (3)  185  -186  2006/09  [Not refereed][Not invited]
  • Ryuichi Takano, Nobuyuki Taniguchi, Kouichi Itoh, Eiji Kusano  Journal of Medical Ultrasonics  33-  (2)  91  -97  2006/06  [Not refereed][Not invited]
    Purpose. To (1) assess the accuracy of the ultrasound velocity profiling (USVP) technique of renal blood flow (RBF) measurement in normal subjects and (2) compare renal blood flow measurements obtained using USVP and renal clearance rate in patients with renal diseases. Methods. First, we calculated unilateral renal blood flow (unil-RBF) using USVP and the clearance rate of para-aminohippuric acid (CPAH) simultaneously in six healthy male subjects. We then compared unil-RBFUSVP and unil-RBFPAH in nine patients with chronic glomerulonephritis (CGN). Results. In the first study, the limits of agreement in a Bland-Altman plot ranged from -325.3 to 32.0 ml/min per 1.48 m2. The mean bias was -146.7 ml/min per 1.48 m 2. Subdivision for values of unil-RBFUSVP by flow showed small discrepancies in values above 280 ml/min per 1.48 m2: mean bias, -98.2 ml/min per 1.48 m2 limits of agreement, -223.3 to 26.8 ml/min per 1.48 m2. The three patients in the second study had immunoglobulin A (IgA) nephropathy, in whom unil-RBFPAH was estimated as being markedly lower than unil-RBFUSVP, contrary to the primary result. Conclusion. Despite its consistent negative bias, USVP may be a reliable method of quantifying renal blood flow noninvasively when measured values exceed 280 ml/min per 1.48 m2. We assumed that the p-aminohippurate extraction rate (EPAH) was profoundly impaired in the three patients with IgA nephropathy. © The Japan Society of Ultrasonics in Medicine 2006.
  • Y Fujii, N Taniguchi, M Hyodo, Y Yasuda, H Nagai, K Itoh  JOURNAL OF CLINICAL ULTRASOUND  34-  (3)  138  -142  2006/03  [Not refereed][Not invited]
    A 55-year-old Japanese man presented with a fist-sized, nonremovable mass in the right lower abdomen. Transabdominal sonographic examination revealed extensive wall thickening without stratification in the distal ileum and cecum, whose echogenicity was homogeneous and extremely low. Some compressibility of the affected bowel was retained. Diagnostic findings obtained with other conventional modalities were consistent with intestinal malignant lymphoma. At surgery, 3 tumors were found in the ileocecal region and the ileum. Histopathological, immunophenotypic, and molecular cytogenetic analysis of resected specimens showed a diffuse Burkitt-like type of B-cell lymphoma. (C) 2006 Wiley Periodicals, Inc.
  • Omoto, K, Hozumi, Y, Nihei, Y, Omoto, Y, Mizunuma, H, Nagai, H, Fujii, Y, Taniguchi, N, Itoh, K  J Med Ultrasonics  33-  (3)  153  -158  2006  [Not refereed][Not invited]
  • Fujii, Y, Taniguchi, N, Itoh, K, Satoh M, Irie T  American Institute of Physics Conference Proceedings of 5th International Symposium on Therapeutic Ultrasound  64  -68  2006  [Not refereed][Not invited]
  • Nobuyuki Taniguchi  Journal of Medical Ultrasonics  32-  (2)  77  -78  2005/06  [Not refereed][Not invited]
  • T Kuwata, N Taniguchi, S Matsubara, T Ono, K Itoh, M Suzuki  ULTRASOUND IN OBSTETRICS & GYNECOLOGY  25-  (6)  586  -591  2005/06  [Not refereed][Not invited]
    Objective To evaluate the accuracy and usefulness of a newly developed three-dimensional automatic bodymarker system for transvaginal ultrasonography. Methods A bodymarker system which utilizes an electromagnetic field to specify the probe position was developed. Software was written which enabled the positional information of the probe and the ultrasound image to be simultaneously displayed on a personal computer. The bodymarker was displayed as a three-dimensional graphic model. The differences between the estimated and the actual position - i.e. the error - for both position (x, y and z) and angles (azimuth, elevation and roll) of the probe were measured. The movement of the probe was then evaluated in healthy female volunteers and the comparative time required for ultrasound examination was determined. Results Both the position and the angles of the probe were accurately shown in the computer display. The errors were 1.0 mm and 0.7 degrees (median) for position and angle, respectively. The system was also shown to work well in healthy female volunteers. Calibration of the new system required only 5.0 seconds, compared with an average of 7.6 seconds for the conventional bodymarker. Conclusion The newly developed three-dimensional automatic transvaginal bodymarker system provides an accurate indication of probe position and its tilting angle. It works well in healthy female volunteers and speeds up the examination time. It may be clinically useful for transvaginal ultrasound examination. Copyright (c) 2005 ISUOG. Published by John Wiley &Sons, Ltd.
  • The effects of Levovist and DD-723 in activating platelets and damaging hepatic cells of rats
    J Ultrasound Med  24(7): 967-974-  2005  [Not refereed][Not invited]
  • Y Fujii, T Shinozaki, H Koibuchi, T Ono, K Omoto, N Taniguchi, K Itoh  JOURNAL OF CLINICAL ULTRASOUND  32-  (7)  361  -364  2004/09  [Not refereed][Not invited]
    We describe the sonographic findings in a case of Lennert's lymphoma, a rare type of peripheral T-cell lymphoma, involving the subcutaneous tissues of the arm. The sonographic appearance was thought to be more helpful than MRI to establish the diagnosis. (C) 2004 Wiley Periodicals, Inc.
  • Yasutomo Fujii, Nobuyuki Taniguchi, Yi Wang, Kouichiro Shigeta, Kiyoka Omoto, Kouichi Itoh, Jing-Wen Tsao, Keuji Kumazaki, Takashi Itoh, Tomotsugu Takayama  Journal of Medical Ultrasonics  31-  (2)  91  -98  2004/06  [Not refereed][Not invited]
    Purpose. We used texture analysis in conjunction with an alternative method of analyzing the amplitude histogram using a radiofrequency (RF) signal to differentiate ultrasonograms of normal and cirrhotic livers. This method segments the region of interest (ROI) into multiple layers (sub-ROIs). In each sub-ROI of a homogeneous medium, the histogram of enveloped-amplitude of RF backscattered echoes resembles a Rayleigh distribution. Theoretically, the values of the signal-to-noise ratio (SNR), skewness, and kurtosis for Rayleigh statistics are constant and independent of the mean scattering intensity, which is contributed by such undesirable effects as tissue attenuation, beam diffraction, and incident waveforms. These values, which averaged overall sub-ROI, should provide an unbiased estimator. Methods. We studied 36 normal livers and 28 cirrhotic livers, all confirmed by clinical findings including laboratory and pathology data the SNR, skewness, and kurtosis values of the disease groups were compared. At the same time, these values were estimated using the conventional method, which did not segment the ROI into multiple sub-ROIs. The unpaired t-test was used to determine statistical significance. Results. With the new method, all values obtained from cirrhotic livers differed significantly from those obtained from normal livers, and the standard deviation of these values was smaller than those obtained using the conventional method. Conclusions. These results suggest that the new method can be used to diagnose the cirrhotic liver objectively. © The Japan Society of Ultrasonics in Medicine 2004.
  • Yasutomo Fujii, Nobuyuki Taniguchi, Ryuichi Takano, Yi Wang, Kouichiro Shigeta, Kiyoka Omoto, Tomoko Ono, Izumi Satoh, Kouichi Itoh  Journal of Medical Ultrasonics  31-  (1)  13  -20  2004/03  [Not refereed][Not invited]
    Purpose. The aim of this study was to estimate the severity of fibrosis without a biopsy. Methods. The signal-to-noise ratio (SNR), skewness, and kurtosis were measured using a 10-MHz transducer with the texture analysis in conjunction with an alternative method for evaluating fibrous rat livers. This method segments the region of interest (ROI) into multiple layers (sub-ROIs). In each sub-ROI of a homogeneous medium, the histogram of enveloped amplitude of radiofrequency (RF) backscattered echoes resembles a Rayleigh distribution. In theory, SNR, skewness, and kurtosis for Rayleigh statistics are constant and independent of the mean scattering intensity, which is enhanced by such undesirable effects as tissue attenuation, beam diffraction, and incident waveforms. Thus, these values, which are averages of the corresponding sub-ROI values, constitute an unbiased estimator. All fibrous liver specimens were induced using the dimethylnitrosamine method. Fiber content was estimated quantitatively as the fibrosis index by computer processing of pathological images obtained by light microscopy. Results. The SNR, skewness and kurtosis, expressed as averages of corresponding values from each sub-ROI, correlated closely with the fibrosis index. Conclusion. These results make it possible to predict the severity of liver fibrosis from data obtained without resorting to biopsy. The data, obtained from our earlier study on rats, may be used to evaluate human hepatitis quantitatively by measuring these three values. The method may make it possible to estimate the degree of severity of chronic liver disease noninvasively. © The Japan Society of Ultrasonics in Medicine 2004.
  • 超音波による小児正常胸腺描出率の検討
    超音波医学  31:J97-101-  2004  [Not refereed][Not invited]
  • Gastric schwannoma –sonographic findings-
    J Ultrasound Med  23: 1528-1530-  2004  [Not refereed][Not invited]
  • Endothelial cell injury and platelet aggregaation induced by contrast ultrasonography in the rat hepatic sinusoid
    J Ultrasound Med  23: 29-36-  2004  [Not refereed][Not invited]
  • Nobuyuki Taniguchi, Tomoyuki Kuwata, Tomoko Ono, Kouichi Itoh, Kiyoka Omoto, Yasutomo Fujii, Akifumi Ootake  Journal of Medical Ultrasonics  30-  (WINTER)  211  -216  2003/12  [Not refereed][Not invited]
    Bodymarkers are used to label the location and orientation of the transducer during ultrasound examination. We attempt to evaluate the usefulness of a new system that indicates transducer location over that of the conventional bodymarker. The proposed system uses an electromagnetic tracking device to track the three-dimensional (3-D) position and orientation of a small electromagnetic receiver attached to the ultrasound transducer relative to a transmitter placed under the bed. The new bodymarker is displayed as a 3-D graphic model. The physique of the examinee is calibrated by representing five locations on the body on the original bodymarker. To evaluate the accuracy of the system visually, we compared the transducer position indicated in the new bodymarker and the actual transducer position in four abdominal sections. Actual and displayed position and orientation closely agreed in all cases, and the transducer position indicator in the bodymarker display moved smoothly. Automatic transducer locator on the virtual 3-D bodymarker accurately indicated its position and orientation. This system is useful and convenient in clinical examinations.
  • Y Fujii, N Taniguchi, T Ono, K Omoto, K Itoh, K Shitoh, M Okada, Y Yasuda, H Nagai  JOURNAL OF CLINICAL ULTRASOUND  31-  (9)  488  -492  2003/11  [Not refereed][Not invited]
    We describe the case of a 75-year-old woman with linitis plastica carcinoma of the colon, accompanied by a peritoneal abscess, in which the use of transabdominal sonography enabled prompt detection and diagnosis. Sonographic examinations revealed diffuse wall thickening with blurred layer stratification in the ascending colon. The irregular outer margin of the affected area was surrounded by thickened pericolic fat. A peritoneal abscess covered by the omentum was also found. CT confirmed these findings. We extensively resected the right half of the colon. Histopathologic examination of the excised segment of the colon revealed a poorly differentiated adenocarcinoma with fibrotic infiltration. The patient was discharged 6 weeks postoperatively, and chemotherapy was begun, but she was lost to our follow-up. Although linitis plastica carcinoma of the colon is rare, it must be considered when patients have extensive colonic wall thickening with blurred layer stratification and an irregular outer margin surrounded by thickened pericolic fat. Transabdominal sonography should be considered the imaging modality of choice for the detection and diagnosis of this disease entity. (C) 2003 Wiley Periodicals, Inc.
  • Tomoko Ono, Nobuyuki Taniguchi, Masaaki Osawa, Akira Onoguchi, Syukuko Kaneko, Yoshitaka Nakazawa, Mikihiko Kawano, Kouichi Itoh  Journal of Medical Ultrasonics  30-  (AUTUMN)  153  -161  2003/09  [Not refereed][Not invited]
    Visceral fat syndrome, which includes visceral fat accumulation, glucose intolerance, hyperlipidemia, and hypertension, refers to a highly atherogenic state with a cluster of risk factors secondary to visceral fat accumulation. Although X-ray computed tomography (CT) is used commonly in diagnosis of visceral fat accumulation, it is expensive and exposes the patient to radiation. Some indices obtained using ultrasonography, which is fast and easy to use, have been reported. The ratio of the maximum thickness of preperitoneal fat (P) to the minimum thickness of subcutaneous fat (S), the abdominal wall fat index (P/S), is widely used in ultrasonographic diagnosis, however, this ratio tends to vary largely according to examiners. To establish a more reliable ultrasonographic index of visceral fat accumulation, we measured the thickness of the mesenterium, and tried to examine the relation between its thickness and maximum thickness of preperitoneal fat, minimum thickness of subcutaneous fat, and abdominal wall fat index, as well as body mass index, systolic and diastolic blood pressure, and levels of serum triglyceride, high-density lipoprotein cholesterol, total cholesterol, and blood sugar. The subjects were 131 individuals, 98 males and 33 females, averaging 47.0±7.9 years, with a mean body mass index of 24.1±2.6. The mesenterium was measured with a 3.5 or 3.75 MHz convex probe by longitudinal scanning on the left side of the umbilicus of the patient in the supine position. The thickness of the mesenterium correlated positively with maximum thickness of the preperitoneal fat, abdominal wall fat index, body mass index, and levels of serum triglyceride, total cholesterol, and blood sugar, and negatively with levels of high-density lipoprotein cholesterol. When the subjects were divided into a high-M group and a normal-M group, body mass index, triglyceride level, and blood sugar levels in the high-M group were significantly higher and level of high-density lipoprotein cholesterol was significantly lower than in the normal-M group. These results suggest that the thickness of mesenteium measured by ultrasonography may be useful in the diagnosis of accumulation of visceral fat.
  • 速度プロファイル法を用いた頸動脈血流量の検討—食事摂取による変化—
    超音波医学  30 (2):J191-197-  2003  [Not refereed][Not invited]
  • 内臓脂肪蓄積の指標としての腸間膜厚の有用性に関する検討. ,
    超音波医学  30:J725-733-  2003  [Not refereed][Not invited]
  • ノカルジアによる軟部組織膿瘍の超音波像
    超音波医学  30(4): J555-560-  2003  [Not refereed][Not invited]
  • 超音波検査が診断に有用であった肺葉外肺分画症の1例
    超音波医学  30(3): j343-347-  2003  [Not refereed][Not invited]
  • T Kuwata, S Matsubara, A Izumi, K Odagiri, T Tsunoda, T Watanabe, N Taniguchi, Sato, I  FETAL DIAGNOSIS AND THERAPY  18-  (1)  8  -11  2003/01  [Not refereed][Not invited]
    An umbilical cord pseudocyst was detected in the 28th week of gestation in a fetus complicated with growth restriction and polyhydramnios. The combination of cord pseudocysts, growth restriction, and polyhydramnios prompted us to perform a detailed ultrasonographic examination (gray scale and three-dimensional), which revealed the presence of micrognathia, overlapping fingers, and congenital heart defects, features characteristic of trisomy 18. Karyotyping confirmed a diagnosis of trisomy 18. After spontaneous labor onset, the infant was delivered at 31 weeks of gestation, and died soon after delivery. An umbilical cord pseudocyst is a good marker for the prenatal detection of trisomy 18. Copyright (C) 2003 S. Karger AG, Basel.
  • Intra- and inter-observer reproducibility of ultrasonic flowmetry using velocity profile color Doppler method by the common carotid artery
    J Med Ultrasonics  30:3-12-  2003  [Not refereed][Not invited]
  • In vitro platelet activation by an echo contrast agent
    J Ultrasound Med  22: 365-373-  2003  [Not refereed][Not invited]
  • M Nakamura, T Shinozaki, N Taniguchi, H Koibuchi, M Momoi, K Itoh  ACTA PAEDIATRICA  92-  (12)  1422  -1426  2003  [Not refereed][Not invited]
    Aim: To evaluate the diagnostic potential of voiding urosonography (VUS) compared with fluoroscopic voiding cystourethrography (VCUG) under identical conditions and to evaluate potential reasons for false-negative VUS results, particularly regarding bladder concentrations of the US contrast agent, Levovist. Methods: Fifty-six paediatric patients (M/F 34/22, mean age 2.3 y, age range 1 mo-14 y) underwent simultaneous VUS and VCUG under identical conditions. The bladder was filled by simultaneous administration of Levovist and the X-ray contrast medium, DIP Conray. Levovist concentrations in bladders were calculated using amounts of Levovist injected and total DIP Conray infused when reflux was first observed in either procedure. Results: Sensitivities of VUS and VCUG for detection of vesicoureteral reflux (VUR) were both 86%, assuming that VUR detected by either method represented a true-positive, and no reflux by either method represented a true-negative. Patients under 24-mo of age displayed a better VUS sensitivity, of 94%. Levovist concentrations in bladders ranged from 1.8% to 23%, with older children tending to demonstrate increased bladder capacity and lower concentration. All VUS false-negative units displayed Levovist bladder concentrations of less than 5%. Conclusion: The present simultaneous study suggests that: 1) the two techniques demonstrate similar sensitivity for detection of reflux; 2) sustained Levovist bladder concentrations of below 5% may not allow detection of reflux on VUS; and 3) VUS represents a suitable technique, particularly for small children whose bladder capacity is not so large.
  • Quantitative processed images acquired by Histogram- SNR imaging used to evaluate parenchymal heterogeneity in the liver
    J Med Ultrasonics  30: 13-19-  2003  [Not refereed][Not invited]
  • Attenuation coefficient measurement in the thyroid
    J Ultrasound Med  22: 1067-1073-  2003  [Not refereed][Not invited]
  • Y Fujii, M Asato, N Taniguchi, K Shigeta, K Omoto, K Itoh, M Suzukawa  JOURNAL OF CLINICAL ULTRASOUND  31-  (1)  55  -58  2003/01  [Not refereed][Not invited]
    We encountered a case of sealed perforated duodenal ulcer in a 75-year-old woman with rheumatoid arthritis and chronic renal failure. Abdominal sonography showed a bright linear echo within the thickened anterior wall of the duodenal bulb and the presence of free air at the anterior surface of the liver. We found no signs of direct communication between the duodenal lumen and the pentoneal cavity or any free fluid. On follow-up sonography performed every 2 days during the first week of the patient's hospitalization, no free fluid was found in the abdomen. The use of sonography to diagnose this patient's sealed perforated duodenal ulcer and to monitor the ulcer for the appearance of free fluid allowed us to provide successful nonsurgical management to this patient. We believe that the use of abdominal sonography in all patients suspected of having a perforated duodenal ulcer may help increase the diagnostic accuracy of this modality and may reduce the need for surgery in such patients. (C) 2002 Wiley Periodicals, Inc.
  • Ultrasound in Med & Biol  28-  (9: 1115-1122)  2002  [Not refereed][Not invited]
  • A new method for attenuation coefficient measurement in the liver -comparison with the spectral shift central frequency method
    J Ultrasound Med  21: 783-788-  2002  [Not refereed][Not invited]
  • Clin Rad  57:846-849.-  2002  [Not refereed][Not invited]
  • J Clin Ultrasound  30-  (1:48-51)  2002  [Not refereed][Not invited]
  • 超音波断層法による小児腎長径の計測ー体位による計測値の変動についてー(共著)
    超音波医学  28-  (6 J927-932)  2001  [Not refereed][Not invited]
  • 超音波で発見された側頚部異所性甲状腺の1例(共著)
    超音波医学  28-  (7)  J999-1002  2001  [Not refereed][Not invited]
  • へき地診療における臨床検査の実施状況−自治医科大学卒業医師に対するアンケ−ト調査から− (共著)
    臨床病理  49(9): 911-916,-  2001  [Not refereed][Not invited]
  • 肝の超音波組織性状診断に関する研究-ラット線維化肝におけるROIの分割化によるRF信号の包絡振幅のヒストグラム解析(共著)
    超音波医学  28-  (4)  J681-692  2001  [Not refereed][Not invited]
  • 肝の超音波組織性状診断に関する研究-ROIの分割化によるRF信号の包絡振幅のヒストグラム解析法を用いた肝硬変の評価(共著)
    超音波医学  28-  (1)  J25-34  2001  [Not refereed][Not invited]
  • J Clin Ultrasound  29-  (7:384-388)  2001  [Not refereed][Not invited]
  • Sonographic fiding of Shigella colitis(共著)
    J Clin Ultrasound  29-  (1)  48  -50  2001  [Not refereed][Not invited]
  • N Taniguchi, K Itoh, Y Wang, K Omoto, K Shigeta, Y Fujii, M Namekawa, S Muramatsu, Nakano, I  JOURNAL OF CLINICAL ULTRASOUND  28-  (9)  488  -491  2000/11  [Not refereed][Not invited]
    Chronic inflammatory demyelinating polyradiculoneuropathy is an autoimmune disease characterized by recurrent demyelination and remyelination with resultant thickening of the peripheral nerves. We report a case in which sonography was instrumental in demonstrating diffuse peripheral nerve hypertrophy. On sonography, both brachial plexuses findings were confirmed by MRI. (C) 2000 John Wiley & Sons, Inc.
  • 唾液腺腫瘍の超音波像及び穿刺吸引細胞診についての検討(共著)
    超音波医学  27-  (9)  1257  -1265  2000  [Not refereed][Not invited]
  • 超音波3次元画像を用いた乳腺腫瘍の抽出と良悪性の自動判別に関する研究-良悪性判定式による術前判定の臨床的検討-(共著)
    超音波医学  27-  (8)  1043  -1048  2000  [Not refereed][Not invited]
  • 小野 倫子, 谷口 信行, 重田 浩一朗, 横田 京子, 中村 みちる, 川井 夫規子, 藤井 康友, Wang Yi, 尾本 きよか, 伊東 紘一  超音波医学  27-  (7)  987  -994  2000  [Not refereed][Not invited]
    症例1は食欲不振を主訴とする59歳男性で,遠隔転移のない胃体上中部のBorrmann 2型胃癌と診断し,胃全摘術,脾合併切除を施行した.超音波検査による経過中,腫瘍塞栓が脾静脈,門脈本幹,肝内の末梢枝へと伸展し,術後11ヵ月で死亡した.症例2は食欲不振を主訴とする77歳男性で,Borrmann 4型胃癌が疑われた.超音波検査では門脈本幹,左胃静脈および脾静脈に充実性エコーが充満し,胃周囲と肝門部のリンパ節が腫脹していたため胃癌による門脈塞栓およびリンパ節転移と診断したが,3ヵ月後に死亡した.症例3は食欲不振,嚥下困難を主訴とする69歳男性で,Borrmann 5型の胃癌と診断した.α-fetoproteinとprotein induced by vitamin K antagonist-IIの著明な上昇,および脾静脈と上腸管膜静脈の合流部の門脈内に充実性腫瘤を認めたため胃癌による肝転移・リンパ節転移および門脈腫瘍塞栓と診断し,化学療法を施行した
  • 超音波断層像による小児の肝計測(共著)
    超音波医学  27-  (7)  973  -980  2000  [Not refereed][Not invited]
  • 超音波カラードプラ所見が診断に有効であって内腸骨動静脈奇形の1例(共著)
    超音波医学  27-  (5)  799  -804  2000  [Not refereed][Not invited]
  • 超音波3次元画像を用いた乳腺腫瘍の抽出と良悪性の自動判別に関する研究-複数のパラメータによる多変量解析を用いた臨床的検討-(共著)
    超音波医学  27-  (2)  119  -129  2000  [Not refereed][Not invited]
  • 超音波検査の信号処理と保存
    臨床病理  48-  (7)  608  -613  2000  [Not refereed][Not invited]
  • 植物,果実の超音波像-描出法とその有用性について
    超音波医学  27-  (10)  1319  -1327  2000  [Not refereed][Not invited]
  • 超音波の画像輝度及び強度の定量的評価法
    超音波医学  27-  (5)  765  -777  2000  [Not refereed][Not invited]
  • 同時生起行列による超音波画像のテクスチャ解析に関する研究およびCT画像情報との比較(共著)
    超音波医学  26-  (7)  825  -838  1999  [Not refereed][Not invited]
  • Clin Radiol  54-  233  -236  1999  [Not refereed][Not invited]
  • 乳腺腫瘍の三次元表示とその良悪性の判定(共著)
    23-  16  -17  1998  [Not refereed][Not invited]
  • Thyroid Tumor's vascularity quantified by power-mode Doppler scanning helps to differentiate their neoplastic characteristics (共著)
    Ultrasound International  4-  (2)  63  -73  1998  [Not refereed][Not invited]
  • Evaluation of automated detection system of three dimensional echography and its clinical application in the detection of breast tumors (共著)
    Ultrasound International  4-  (1)  4  -11  1998  [Not refereed][Not invited]
  • N Taniguchi, K Itoh, S Nakamura, T Obayashi, F Kawai, M Nakamura  JOURNAL OF UROLOGY  157-  (4)  1242  -1245  1997/04  [Not refereed][Not invited]
    Purpose: We determined the usefulness of ultrasonic frequency dependent attenuation in differentiating hyperechoic renal cell carcinoma from angiomyolipoma. Materials and Methods: Frequency dependent attenuation values were determined in 29 renal cell carcinomas and 13 angiomyolipomas. Results: Frequency dependent attenuation values were significantly lower in renal cell carcinomas than in angiomyolipomas (0.42 versus 0.76 dB./cm./MHz.). Two of the renal cell carcinomas were as hyperechoic as the angiomyolipomas but they were clearly differentiated by the low frequency dependent attenuation. Two other renal cell carcinomas exhibited high values because of the abundance of fibrous tissue. However, they were readily diagnosed by the typical low echoic B-mode images. Frequency dependent attenuation did not differ between histological types of renal cell carcinoma. One angiomyolipoma that was poor in fat and rich in muscle components had an exceptionally low frequency dependent attenuation. Therefore, frequency dependent attenuation values can be regarded as an inversion of computerized tomography numbers. Conclusions: Frequency dependent attenuation measurement is a promising diagnostic aid in differentiating hyperechoic renal cell carcinomas from angiomyolipomas.
  • 正常ならびに病的肝とファントムを用いた同時生起行列によるテクスチャ解析に関する研究-超音波画像の関心領域の深度、走査断面、周波数および拡大率の検討-(共著)
    超音波医学  24-  (6)  861  -872  1997  [Not refereed][Not invited]
  • 超音波組織性状診断に関する研究-ヒト鉄沈着肝の周波数依存減衰およびエコー輝度の検討-(共著)
    超音波医学  24-  (1)  11  -20  1997  [Not refereed][Not invited]
  • Automated detection of breast tumors in ultrasonic images using fuzzy reasoning. Proceeding of the International conferen econ Image Processing Volume (]G0003[).
    IEEE proceedings  imaging processwing III 420-423-  1997  [Not refereed][Not invited]
  • Ultrasonic tissue characterization by texture analysis using normal and pathologic livers and a reference phantom : relationship between depth range, scanning plane, probe frequency, and magnification rate in the ultrasound image
    Journal of Medical Ultrasonics  24-  (6)  861  -872  1997  [Not refereed][Not invited]
  • Ultrasonic tissue characterization measurement of frequency dependent attenuation and echo level human siderotic livers
    Journal of Medical Ultrasonics  24-  (1)  11  -20  1997  [Not refereed][Not invited]
  • Assessment of visceral fat related risk factors by ultrasonography (共著)
    Ultrasound International  3-  (4)  206  -215  1997  [Not refereed][Not invited]
  • A new tool that uses the amplitude method to determine ultrasonic attenuatiion in both normal and fatty livers (共著)
    Ultrasound International  3-  (2)  67  -71  1997  [Not refereed][Not invited]
  • N Taniguchi, K Itoh, M Honda, T Obayashi, M Nakamura, F Kawai, T Irie  ANGIOLOGY  48-  (1)  9  -20  1997/01  [Not refereed][Not invited]
    The purpose of this study was to compare the usefulness of ultrasonography to that of angiography for studying arterial lesions in Takayasu's arteritis. Ultrasonographic and angiographic findings from 44 carotid arteries of 22 patients with Takayasu's arteritis (2 men and 20 women; mean age, 41.2 years) were compared. Angiography was used to classify the patency of the carotid arteries into three groups: nonstenotic, stenotic, and occlusive. Ultrasonography was also used to classify the same arteries into four groups: nonstenotic, mildly stenotic, moderately stenotic, and occlusive. Thickness of the wall (intima-media complex) of the carotid artery was measured with high-frequency transducers. Angiography showed 23 carotid arteries to be nonstenotic; 12, stenotic; and 9, occlusive; whereas ultrasonography showed 16 to be nonstenotic; 18, mildly stenotic; 7, moderately stenotic; and 3, occlusive. Results of the two diagnostic modalities correlated closely (P < 0.0001). Ultrasonography, aided by color flow imaging, detected six instances of a marginal but definite blood flow that angiography had failed to reveal. Arterial wall thickness correlated closely with the severity of ultrasonographic stenosis (P < 0.005). This thickness was 1.3 +/- 0.4 mm in the nonstenotic group, 1.6 +/- 0.5 mm in the mildly stenotic group, 2.2 +/- 0.8 mm in the moderately stenotic group, and 1.9 +/- 0.2 mm in the occlusive group. Even the walls of the nonstenotic arteries were significantly thicker than those of the normal carotid arteries (0.7 +/- 0.1 mm, P < 0.01). Ultrasonography appeared to be more useful than angiography in estimating stenotic severity of the carotid artery in Takayasu's arteritis. Characteristic ultrasonic findings included luminal stenosis or occlusion on two-dimensional ultrasonograms, decrease in or lack of flow shown by color Doppler flow imaging, and concentric thickening of the carotid arterial walls. Ultrasonographic mural thickness was the most sensitive indicator of early, latent inflammation.
  • 超音波による門脈血流の検討-カラードプラ法および速度プロファイルを用いて-
    超音波医学  23-  (10)  731  -736  1996  [Not refereed][Not invited]
  • 超音波組織性状診断に関する研究-ラット鉄沈着肝の周波数依存減衰およびエコー輝度の検討(共著)
    超音波医学  23-  123  -136  1996  [Not refereed][Not invited]
  • 超音波カラードプラ法を用いた速度プロファイルによる血流量計測法-原理およびファントムを用いた検討
    超音波医学  23-  313  -318  1996  [Not refereed][Not invited]
  • Estimation of portal venous flow using the color Doppler method and velocity profiles
    Japanese Journal of Medeical Ultrasonics  23-  (10)  731  -736  1996  [Not refereed][Not invited]
  • Studies in tissue characterization : measurement of frequency dependent attenuation and echo levels in siderotic lives of rats
    Japanese Journal of Medical Ultrasonics  23-  123  -136  1996  [Not refereed][Not invited]
  • 超音波カラードプラ法を用いた速度プロファイルおよびPower mode2プロファイルの評価法-血管への応用
    超音波医学  22-  (12)  877  -883  1995  [Not refereed][Not invited]
  • 特定型的なCT所見を呈した副腎骨髄脂肪腫の1例(共著)
    超音波医学  22-  (8)  617  -620  1995  [Not refereed][Not invited]
  • 小児顎下腺エコーレベルの年齢的変化(共著)
    超音波医学  22-  (11)  775  -780  1995  [Not refereed][Not invited]
  • 孤立性解離性上腸間膜動脈瘤の1例 (共著)
    超音波医学  22-  (2)  181  -186  1995  [Not refereed][Not invited]
  • 乳癌の組織音響特性に関する研究 -組織型と周波数依存減衰、エコー輝度、縦横比との関連について- (共著)
    超音波医学  22-  (1)  3  -18  1995  [Not refereed][Not invited]
  • Ultrasonic studies of subclavian arterial lesions in Takayasu's arteritis : comparison with angiography and strength of radial pulse.
    Ultrasound International  1-  (4)  184  -193  1995  [Not refereed][Not invited]
  • Method for using color Doppler signal to estimate velocity and power-mode profiles : application to the arteries
    Japanese Journal of Medical Ultrasonics  22-  (12)  877  -883  1995  [Not refereed][Not invited]
  • Age-dependent change in submandibular echo level children
    Japanese Journal of Medical Ultrasonics  22-  (11)  775  -780  1995  [Not refereed][Not invited]
  • Usefulness of color Doppler imaging to differentiate parathyroid tumor from papillary thyroid carcinoma
    Ultrasound International  1-  (1)  16  -21  1995  [Not refereed][Not invited]
  • Studies of acoustic tissue characterization of breast carcinoma : relationship between pathological findings, frequency-dependent attenuation, echo intensity, and Depth/width ratio
    Japanese Journal of Medical Ultrasonics  22-  (1)  3  -18  1995  [Not refereed][Not invited]
  • Development of three-dimentional ultrasound equipment and its clinical application(共著)
    Ultrasound International  1-  (1)  28  -39  1995  [Not refereed][Not invited]
  • 甲状腺乳頭癌の超音波像と病理組織との比較検討 (共著)
    超音波医学  21-  (4)  181  -189  1994  [Not refereed][Not invited]
  • 悪性リンパ腫における限局性脾病変の検討 -超音波像と病理組織型の関連および治療反応性について- (共著)
    超音波医学  21-  (11)  713  -722  1994  [Not refereed][Not invited]
  • Correlation between the ultrasonographic and pathologic characteristics of papillary carcinoma of the thyroid.
    Japanese Journal of Medical Ultrasonics  21-  (4)  181  -189  1994  [Not refereed][Not invited]
  • 超音波画像のフラクタル解析による組織性状診断の可能性(共著)
    超音波医学  20-  (11)  643  -652  1993  [Not refereed][Not invited]
  • 膵生検
    臨床と研究  70-  (7)  2076  -2079  1993  [Not refereed][Not invited]
  • 甲状腺結節性病変に対するカラードプラ断層法の応用に関する検討(共著)
    超音波医学  20-  (4)  205  -211  1993  [Not refereed][Not invited]
  • 超音波組織性状診断に関する研究-ラット脂肪肝の周波数依存減衰およびエコー輝度の計測-
    超音波医学  20-  (10)  574  -588  1993  [Not refereed][Not invited]
  • Fractal analysis of ultrasonic images for tissue characterization
    Japanese Journal of Medical Ultrasonics  20-  (11)  643  -652  1993  [Not refereed][Not invited]
  • 超音波像による正中頚嚢胞の検討
    超音波医学  19-  (1)  1992  [Not refereed][Not invited]
  • 超音波像による副腎腫瘤の検討-腺腫と転移性腫瘍の鑑別について-
    超音波医学  19-  (3)  1992  [Not refereed][Not invited]
  • 超音波による横隔膜像の観察及び呼吸による厚さの変化の検討
    超音波医学  18-  (1)  1991  [Not refereed][Not invited]
  • 超音波による横隔膜厚の検討-体位変化及び呼吸機能との関連について-
    超音波医学  18-  (6)  1991  [Not refereed][Not invited]
  • ヒストグラムによる脂肪肝の肝腎コントラストの評価法とその問題点について
    超音波医学  18-  (9)  1991  [Not refereed][Not invited]
  • Ultrasonography of ovary, uterus and breast in premature the larche(共著)
    Acta Paediatr Jpn  33-  645  -648  1991  [Not refereed][Not invited]
  • Frequency dependent attenuation in tumors of the liver(共著)
    Japanese Journal of Medical Ultrasonics  18-  (2)  160  -167  1991  [Not refereed][Not invited]
  • 肝内の周波数信号を利用した体表組織の減衰値の推定法-脂肪肝の肝エコーレベル測定への応用-
    超音波医学  17-  1990  [Not refereed][Not invited]
  • Salivary gland echo-graphy in patients with Sjogren's Syndrome(共著)
    Arthritis and Rheumatism  30-  (4)  505  -510  1990  [Not refereed][Not invited]
  • 限局性脾病変の超音波診断
    超音波医学  16-  (5)  438  -447  1989  [Not refereed][Not invited]
  • Spectral Shift Zero Crossing法による周波数依存減衰に関する臨床的研究-新生児・乳児への応用
    2-  1989  [Not refereed][Not invited]
  • 正常骨挌筋の周波数依存減衰に関する臨床的研究
    超音波医学  16-  383  -392  1989  [Not refereed][Not invited]

Industrial Property Rights

  • 流量計測機能を備えた超音波ドプラ診断装置
  • 超音波診断装置
  • 超音波造影剤
  • 超音波診断装置

Awards & Honors

  • 2004 日本超音波医学会菊池賞
  • 2003/05 第2回日本超音波医学会 松尾賞

Research Grants & Projects

  • 超音波カラードプラ法を用いた血流量計測
  • 超音波を用いた組織性状診断
  • Ultrasonic volumetry using color Doppler method
  • Ultrasonic Tissue Characterization

Committee Membership

  • 2002 -2004   Japan Society of ultrasound in Medicine   Trustee   Japan Society of ultrasound in Medicine

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