Researchers Database

nunomiya shin

    Professor
Last Updated :2021/10/17

Researcher Information

Degree

  • Doctor (Medicine)(Yamagata University)

J-Global ID

Research Interests

  • 集中治療医学   Intensive and Critical Care Medicine   

Research Areas

  • Life sciences / Emergency medicine
  • Life sciences / Anesthesiology

Academic & Professional Experience

  • 2006/02 - Today  Jichi Medical UniversitySchool of Medicine教授
  • 2002/08 - 2006/01  Jichi Medical UniversitySchool of Medicine助教授
  • 1993 - 2002  Jichi Medical University
  • 1992 - 1993  Jichi Medical University

Education

  • 1976/04 - 1982/03  Jichi Medical University  医学部  医学科
  •        - 1972  Jichi Medical University  Faculty of Medicine

Association Memberships

  • European Society of Intensive Care Medicine   日本臨床モニター学会   日本ショック学会   日本集中治療医学会関東甲信越地方会   日本循環制御医学会   日本麻酔・薬理学会   日本呼吸療法医学会   日本蘇生学会   日本救急医学会   日本臨床麻酔学会   日本麻酔科学会   日本集中治療医学会   

Published Papers

  • Toshitaka Koinuma, Shin Nunomiya, Masahiko Wada, Kansuke Koyama, Takahiro Suzuki
    Journal of Intensive Care 2 (1) 48  2052-0492 2014/08 [Refereed][Not invited]
     
    Idiopathic pneumonia syndrome (IPS) is a fatal non-infectious respiratory complication that develops after hematopoietic stem cell transplantation (HSCT). Because of the poor prognosis of post-HSCT patients with IPS requiring mechanical ventilatory support, performing extracorporeal membrane oxygenation (ECMO) has been regarded as relatively contraindicated in these patients. A tumor necrosis factor-alpha inhibitor, etanercept, has been reported to be a promising treatment option for post-HSCT patients with IPS however, the phase III clinical trial of etanercept has recently been terminated without definitive conclusion. If post-HSCT patients with IPS really benefit from etanercept, mechanical ventilation (MV)-dependent IPS patients might be worth receiving ECMO treatment in line with the protective lung strategy. We therefore performed veno-venous ECMO (VV-ECMO), which substantially acted as an extracorporeal carbon dioxide removal, on a 56-year-old post-HSCT male with severe MV-dependent IPS due to graft-versus-host disease. Although a serious bleeding complication due to post-HSCT thrombocytopenia occurred, the VV-ECMO was continued for 11 days. The patient successfully entered remission of the IPS and was finally extubated on the 12th MV day. However, the patient soon complained of dyspnea, probably due to cytomegalovirus infection and/or exacerbation of the IPS, and was reintubated after 3 days of extubation. The patient then rapidly developed irreversible type II respiratory failure despite the administration of etanercept and an anti-cytomegalovirus agent and died on the eighth re-MV day. The autopsy findings of the patient revealed diffuse alveolar damage and alveolar hemorrhage, accompanied with bronchitis obliterans in his lungs, as well as whole body cytomegalovirus infection, which were compatible with the clinical diagnosis of the patient. We think that the legitimacy of this treatment strategy is dependent on the overall prognosis of IPS, which is influenced by the complications induced by immunosuppressants and ECMO, especially infections and bleeding.
  • Koinuma T, Nunomiya S, Wada M, Koyama K
    Nihon Naika Gakkai zasshi. The Journal of the Japanese Society of Internal Medicine 103 (8) 1931 - 1934 0021-5384 2014/08 [Refereed][Not invited]
  • Ryosuke Tsuruta, Yasutaka Oda, Ayumi Shintani, Shin Nunomiya, Satoru Hashimoto, Takashi Nakagawa, Yasuhisa Oida, Dai Miyazaki, Shigemi Yabe
    JOURNAL OF CRITICAL CARE 29 (3) 472.e1 - 5 0883-9441 2014/06 [Refereed][Not invited]
     
    Purpose: The object of this study is to evaluate the prevalence and effects of delirium on 28-day mortality in critically ill patients on mechanical ventilation in Japan. Materials and methods: Prospective cohort study was conducted in medical and surgical intensive care units (ICUs) of 24medical centers. Patients were followed up daily for delirium during ICU stay after enrollment. Coma was defined with the Richmond Agitation Sedation Scale score of -4 or -5. Delirium was diagnosed using the Confusion Assessment Method for the ICU. The Cox proportional hazards regression model was used to assess the effects of delirium and coma on 28-day mortality, time to extubation, and time to ICU discharge; delirium and coma were included as time-varying covariates after controlling for age, Acute Physiology and Chronic Health Evaluation II score, ventilator-associated pneumonia, and the reason for intubation with infection. Results: Of 180 patients, 115 patients (64%) developed delirium. Moreover, 15 patients (8%) died within 28 days after ICU admission, including 7 patients who experienced coma and 8 patients who experienced both coma and delirium. There were no deaths among patients who did not experience coma. Delirium was associated with a shorter time to extubation (hazard ratio [HR], 2.52; 95% confidence interval [CI], 1.65-3.85; P < .001) and a shorter ICU length of stay in comatose patients (HR, 1.59; 95% CI, 1.04-2.44; P =. 034), whereas delirium appeared with prolonged time to ICU discharge among patients without coma, although statistical significance was not detected due to limited analytical power (HR, 0.62; 95% CI, 0.34-1.12; P =. 114). Delirium during ICU stay was not associated with higher mortality. Conclusions: Further study is needed to investigate the discrepancy between these and previous data. (C) 2014 Elsevier Inc. All rights reserved.
  • Kansuke Koyama, Seiji Madoiwa, Shin Nunomiya, Toshitaka Koinuma, Masahiko Wada, Asuka Sakata, Tsukasa Ohmori, Jun Mimuro, Yoichi Sakata
    Critical Care 18 (1) R13  1364-8535 2014/01 [Refereed][Not invited]
     
    Introduction: Current criteria for early diagnosis of coagulopathy in sepsis are limited. We postulated that coagulopathy is already complicated with sepsis in the initial phase, and severe coagulopathy or disseminated intravascular coagulation (DIC) becomes overt after progressive consumption of platelet and coagulation factors. To determine early diagnostic markers for severe coagulopathy, we evaluated plasma biomarkers for association with subsequent development of overt DIC in patients with sepsis.Methods: A single-center, prospective observational study was conducted in an adult ICU at a university hospital. Plasma samples were obtained from patients with sepsis at ICU admission. Fourteen biomarkers including global markers (platelet count, prothrombin time, activated partial thromboplastin time, fibrinogen and fibrin degradation product (FDP)) markers of thrombin generation (thrombin-antithrombin complex (TAT) and soluble fibrin) markers of anticoagulants (protein C (PC) and antithrombin) markers of fibrinolysis (plasminogen, α2-plasmin inhibitor (PI), plasmin-α2-PI complex, and plasminogen activator inhibitor (PAI)-1) and a marker of endothelial activation (soluble E-selectin) were assayed. Patients who had overt DIC at baseline were excluded, and the remaining patients were followed for development of overt DIC in 5 days, and for mortality in 28 days.Results: A total of 77 patients were enrolled, and 37 developed overt DIC within the following 5 days. Most patients demonstrated hemostatic abnormalities at baseline with 98.7% TAT, 97.4% FDP and 88.3% PC. Most hemostatic biomarkers at baseline were significantly associated with subsequent development of overt DIC. Notably, TAT, PAI-1 and PC discriminated well between patients with and without developing overt DIC (area under the receiver operating characteristic curve (AUROC), 0.77 (95% confidence interval, 0.64 to 0.86) 0.87 (0.78 to 0.92) 0.85 (0.76 to 0.91), respectively), and using the three together, significantly improved the AUROC up to 0.95 (vs. TAT, PAI-1, and PC). Among the significant diagnostic markers for overt DIC, TAT and PAI-1 were also good predictors of 28-day mortality (AUROC, 0.77 and 0.81, respectively).Conclusions: Severe coagulation and fibrinolytic abnormalities on ICU admission were associated with subsequent development of overt DIC. A single measurement of TAT, PAI-1, and PC activity could identify patients with ongoing severe coagulopathy, early in the course of sepsis. © 2014 Koyama et al. licensee BioMed Central Ltd.
  • Kansuke Koyama, Seiji Madoiwa, Shinichiro Tanaka, Toshitaka Koinuma, Masahiko Wada, Asuka Sakata, Tsukasa Ohmori, Jun Mimuro, Shin Nunomiya, Yoichi Sakata
    Journal of Critical Care 28 (5) 556 - 563 0883-9441 2013/10 [Refereed][Not invited]
     
    Purpose: The hemostatic biomarkers for early diagnosis of sepsis-associated coagulopathy have not been identified. The purpose of this study was to evaluate hemostatic biomarker abnormalities preceding a decrease in platelet count, which is a surrogate indicator of overt coagulopathy in sepsis. Materials and Methods: Seventy-five septic patients with a platelet count more than 80 × 103/μL were retrospectively analyzed. Hemostatic biomarkers at intensive care unit admission were compared between patients with and patients without a subsequent decrease in platelet count (≥30% within 5 days), and the ability of biomarkers to predict a decrease in platelet count was evaluated. Results: Forty-two patients (56.0%) developed a subsequent decrease in platelet count. Severity of illness, incidence of organ dysfunction, and 28-day mortality rate were higher in patients with a subsequent decrease in platelet count. There were significant differences between patients with and patients without a subsequent decrease in platelet count in prothrombin time-international normalized ratio, fibrinogen, thrombin-antithrombin complex, antithrombin, protein C (PC), plasminogen, and α2-plasmin inhibitor (α2-PI). Receiver operating characteristic curve analysis showed that PC (area under the curve, 0.869 95% confidence interval, 0.699-0.951) and α2-PI (area under the curve, 0.885 95% confidence interval, 0.714-0.959) were strong predictors of a subsequent decrease in platelet count. Conclusions: Decreased PC and α2-PI activity preceded a decrease in platelet count in intensive care unit patients with sepsis. © 2013 Elsevier Inc.
  • Yoshinori Hosoya, Miho Matsumura, Seiji Madoiwa, Toru Zuiki, Shiro Matsumoto, Shin Nunomiya, Alan Lefor, Naohiro Sata, Yoshikazu Yasuda
    Surgery Today 43 (6) 670 - 674 0941-1291 2013/06 [Refereed][Not invited]
     
    We report a case of acquired hemophilia A (AHA) after esophageal resection. The patient was an 80-year-old woman whose preoperative activated partial-thromboplastin time (APTT) was well within the normal range, at 34.9 s. She underwent thoracic esophagectomy and gastric pull-up for superficial esophageal cancer (operative time, 315 min intraoperative blood loss, 245 ml). Intrathoracic and subcutaneous bleeding occurred spontaneously on postoperative day (POD) 39. The APTT was prolonged, at 140 s, and factor VIII inhibitor was 36 Bethesda U/ml. Treatment with recombinant activated factor VII, prednisolone, and cyclophosphamide resulted in remission within 2 months. This case supports an association between surgery and the triggering of factor VIII inhibitors. The diagnosis of AHA requires clinical acumen and must be considered in any patient with bleeding and a prolonged APTT. © 2012 Springer.
  • Shinshu Katayama, Shin Nunomiya, Masahiko Wada, Kazuhide Misawa, Shinichiro Tanaka, Kansuke Koyama, Toshitaka Koinuma
    Indian Journal of Critical Care Medicine 16 (4) 241 - 244 0972-5229 2012/10 [Refereed][Not invited]
     
    Glyceol® is an intracranial pressure reducing agent composed of 5% fructose and concentrated glycerol. Although rapid administration of fructose is known to cause lactic acidosis, little is known about hyperlactatemia caused by Glyceol® administration itself in adults. We observed an adult case of hyperlactatemia occurred after administration of 200 mL of Glyceol® over a period of 30 minutes. Since there was no evidence of an underlying liver disease or metabolic abnormality, and no findings of sepsis or impaired tissue perfusion, the cause of this condition was deemed to be the rapid loading of fructose contained as a constituent of Glyceol®. We then performed a retrospective chart review and found other 9 cases admitted to Jichi Medical University Hospital ICU and administered Glyceol® during the past year. Their lactate levels increased in general, peaked approximately 45 minutes after Glyceol ® administration and returned to pre-administration levels around 3 hours after. Although hyperlactatemia is an important indicator of sepsis and impaired tissue perfusion, caution is required when performing such an assessment in patients being administered Glyceol®.
  • Yukihiro Sanada, Koichi Mizuta, Taizen Urahashi, Yoshiyuki Ihara, Taiichi Wakiya, Noriki Okada, Naoya Yamada, Toshitaka Koinuma, Kansuke Koyama, Shinichiro Tanaka, Kazuhide Misawa, Masahiko Wada, Shin Nunomiya, Yoshikazu Yasuda, Hideo Kawarasaki
    THERAPEUTIC APHERESIS AND DIALYSIS 16 (4) 368 - 375 1744-9979 2012/08 [Refereed][Not invited]
     
    In the field of pediatric living donor liver transplantation, the indications for apheresis and dialysis, and its efficacy and safety are still a matter of debate. In this study, we performed a retrospective investigation of these aspects, and considered its roles. Between January 2008 and December 2010, 73 living donor liver transplantations were performed in our department. Twenty seven courses of apheresis and dialysis were performed for 19 of those patients (19/73; 26.0%). The indications were ABO incompatible-liver transplantation in 11 courses, fluid management in seven, acute liver failure in three, renal replacement therapy in two, endotoxin removal in two, cytokine removal in one, and liver allograft dysfunction in one. Sixteen courses of apheresis and dialysis were performed prior to liver transplantation for 14 patients. The median IgM antibody titers before and after apheresis for ABO blood type-incompatible liver transplantation was 128 and eight, respectively (P < 0.05). Eleven courses of apheresis and dialysis were performed post liver transplantation for 10 patients. The median PaO2/FiO2 ratio before and after dialysis for fluid overload was 159 and 339, respectively (P < 0.05). No bleeding or technical complications attributable to apheresis and dialysis occurred. The 1-year survival rate of the patients was 100%. Apheresis and dialysis in pediatric living donor liver transplantation are effective for antibody removal in ABO-incompatible liver transplantation, and fluid management for acute respiratory failure.
  • Toshitaka Koinuma, Shin Nunomiya, Masahiko Wada, Kazuhide Misawa, Shinichiro Tanaka, Kansuke Koyama
    Japanese Journal of Anesthesiology 61 (2) 170 - 176 0021-4892 2012/02 [Refereed][Not invited]
     
    Background: The risk factors for postoperative myasthenic crisis (MC) in patients with myasthenia gravis (MG) receiving preoperative corticosteroids were unknown. Methods: Sixty-three consecutive patients who had undergone a transsternal thymectomy for MG were retrospectively analyzed. Of these, 59 patients (93.7%) received preoperative corticosteroids (prednisolone 1-2 mg·kg -1) every-other day. In this study, our definition of postoperative-MC was the need for prolonged postoperative mechanical ventilation for more than 48 hours. Six patients (9.5%) met this criterion. The patient background, and preoperative as well as intraoperative management were evaluated to identify risk factors for postoperative-MC. Results: Student's t-test revealed that the lengths of the operation and anesthesia were significantly longer in the postoperative-MC group compared with the control group (P< 0.05). Fisher's exact test revealed that the existence of preoperative bulbar symptoms and incomplete resection of the thymus gland were also more common in the postoperative-MC group (P< 0.05). A logistic regression analysis revealed that the existence of preoperative bulbar symptoms was the only significant risk factor for postoperative-MC. Conclusions: Based on this study, we concluded that the existence of preoperative bulbar symptoms seems to be a predictor for the development of postoperative-MC in patients with MG undergoing a transsternal thymectomy.
  • Seiji Madoiwa, Shin Nunomiya, Tornoko Ono, Yuichi Shintani, Tsukasa Ohmori, Jun Mimuro, Yoichi Sakata
    INTERNATIONAL JOURNAL OF HEMATOLOGY 84 (5) 398 - 405 0925-5710 2006/12 [Refereed][Not invited]
     
    Sepsis-induced disseminated intravascular coagulation (DIC) is a serious condition because it is closely linked to the development of multiple organ dysfunctions. We compared molecular fibrinolysis markers for 117 patients with sepsis-induced DIC and 1627 patients with nonseptic DIC. Levels of fibrinogen and fibrin degradation products and D-dimer were significantly lower in sepsis-induced DIC cases than in nonseptic DIC cases. In septic DIC cases, plasma plasminogen activator inhibitor I (PAI-1) levels were significantly higher than in nonseptic DIC cases. D-dimer levels were negatively correlated with plasma PAI-1 levels in septic DIC cases. Multiple Organ Dysfunction Scores were significantly higher in septic DIC patients with PAI-1 levels > 90 ng/mL than in the group with PAI-1 levels < 30 ng/mL. The Kaplan-Meier survival functions until 28 days after DIC diagnosis were significantly lower in the group with PAI-1 levels > 90 ng/mL than in the other groups. In a multivariate analysis, plasma PAI-I levels at DIC diagnosis were an independent risk factor for mortality in sepsis-induced DIC (hazard ratio, 1.012; P =.008). These data suggest that plasma PAI-1 plays an important role in sustaining DIC in septic DIC cases and contributes to multiple organ failure and decreased survival in such patients.
  • Shinichiro Tanaka, Masaaki Satoh, Yoshihiro Hirabayashi, Shin Nunomiya, Norimasa Seo
    Japanese Journal of Anesthesiology 55 (10) 1270 - 1272 0021-4892 2006/10 [Refereed][Not invited]
     
    We report a case of anaphylactic shock induced by an antibiotic administrated after induction. A 39-year-old man was scheduled for removal of right adrenal tumor. After insertion of an epidural catheter, anesthesia was induced with an intravenous bolus injection of fentanyl 100 μg, propofol 130 mg and vecuronium 6 mg. The trachea was intubated smoothly and anesthesia was maintained with sevoflurane. Sultamicillin tosilate was administrated intravenously. Soon, ephedrine 12 mg was given intravenously because his blood pressures decreased. However, his blood pressure did not recover, but fell down to 35/22 mmHg. He was turned to head-down position, and 100% oxygen was administrated. Following epinephrine 0.1 mg injection, his blood pressure increased to 80/40 mmHg. Epinephrine at 0.005-0.02 μg · kg -1 · min-1 was infused continuously to maintain his blood pressure. We found erhythemia on his face, shoulders and arms. Hydrocortisone sodium succinate and acetate Ringer's solution were administrated to treat his anaphylactic shock and the surgery was postponed. The blood samples indicated that this event was IgE-mediated anaphylactic reaction. From his past history, penicillin allergy was confirmed. The surgery was rescheduled and anesthesia was managed in the same way as previous one. Surgery was successfully performed using levofloxacin, which had been taken orally before induction of anesthesia.
  • Kazuko Momose, Shin Nunomiya, Masanori Nakata, Toshihiko Yada, Motoshi Kikuchi, Takashi Yashiro
    MEDICAL MOLECULAR MORPHOLOGY 39 (3) 146 - 153 1860-1480 2006/09 [Refereed][Not invited]
     
    The Goto-Kakizaki (GK) rat offers a genetic model of type 2 diabetes and displays profoundly defective insulin secretion leading to basal hyperglycemia. This animal is widely used for studying type 2 diabetes. However, the morphological characteristics of the pancreatic islets of Langerhans in GK rats are not fully understood. The present study sought to clarify this issue using immunohistochemical and electron microscopic techniques. GK rats were killed at 7, 14, 21, and 35 weeks of age. Structural islet changes were not observed at 7 weeks old. At 14 and 21 weeks of age, GK rats displayed histopathological islet changes. The general shape of islets became irregular, and immunoreaction of beta-cells against antiinsulin appeared diffusely weakened. Electron microscopy revealed that the numbers of so-called beta-granules decreased and the numbers of immature granules increased. The Golgi apparatus of beta-cells was developed and the cisternae of rough endoplasmic reticulum were often dilated, indicating hyperfunction of the cells. However, at 35 weeks old, immunoreactivities of dispersed beta-cells into the exocrine portion recovered, and numbers of secretory granules increased again and features of the cell organelles did not display hyperfunction. These results suggest that insulin deficiency in GK rats is not caused by simple dysfunction and/or degeneration of beta-cells but rather by more complicated events within cells.

Books etc

  • 布宮 伸, 茂呂 悦子 (Joint work)
    学研メディカル秀潤社 2010/07 4780908299 100
  • 布宮 伸 (Editor)
    克誠堂出版 2009/08 4771903581 188
  • 布宮 伸 (Single work)
    メヂカルフレンド社 2007/07 4839213453 214
  • 化学物質吸入による急性肺水腫
    ()
    ARDSのすべて,医歯薬出版 2004
  • 布宮 伸, 菊池 睦子, 中村 好一 (Joint work)
    照林社 2003/04 4796527230 179
  • 総合的ICUにおける鎮静 -術後,外傷ならびに一般的な内科の患者-.
    ()
    ディプリバン鎮静の手引き,Excerpta Medica 2003
  • 気管支拡張薬
    ()
    コメディカルのための呼吸療法マニュアル,メディカ出版 2003
  • 略語・英和用語集
    ()
    最新 ケアにいかす看護数値の事典,照林社 2003
  • 院内感染対策
    ()
    最新 ケアにいかす看護数値の事典,照林社 2003
  • 臨床検査基準値
    ()
    最新 ケアにいかす看護数値の事典,照林社 2003
  • 主な単位記号(略号)と意味
    ()
    最新 ケアにいかす看護数値の事典,照林社 2003
  • 救急看護に必要な看護数値
    ()
    最新 ケアにいかす看護数値の事典,照林社 2003
  • 母性看護に必要な看護数値(共著)
    ()
    最新 ケアにいかす看護数値の事典,照林社 2003
  • 小児疾患患者に必要な看護数値(共著)
    ()
    最新 ケアにいかす看護数値の事典,照林社 2003
  • 老年看護に必要な看護数値(共著)
    ()
    最新 ケアにいかす看護数値の事典,照林社 2003
  • 成人看護に必要な看護数値(共著)
    ()
    最新 ケアにいかす看護数値の事典,照林社 2003
  • 診療に伴う看護数値(共著)
    ()
    最新 ケアにいかす看護数値の事典,照林社 2003
  • 日常生活援助のための看護数値(共著)
    ()
    最新 ケアにいかす看護数値の事典,照林社 2003
  • 麻酔.
    ()
    コア・カリキュラム対応 診療の基本,金芳堂 2002
  • 慢性呼吸不全と急性増悪.
    ()
    呼吸管理,医学図書出版 2002
  • 人工呼吸器装着患者のケアのための知識・技術 起こりやすい精神症状と精神的ケア.
    ()
    最新人工呼吸ケア,メヂカルフレンド社 2001
  • 人工呼吸器装着患者のケアのための知識・技術 感染予防.
    ()
    最新人工呼吸ケア,メヂカルフレンド社 2001
  • 周術期管理 肺外科
    ()
    集中治療医学,秀潤社 2001
  • 池松 裕子, 布宮 伸, 道又 元裕, 田中 行夫 (Joint editor)
    照林社 2000/10 4796527192 319
  • 心拍出量モニタリング
    ()
    クリティカルケアマニュアル,照林社 2000
  • 混合静脈血酸素飽和度モニタリング
    ()
    クリティカルケアマニュアル,照林社 2000
  • 左心房圧モニタリング
    ()
    クリティカルケアマニュアル,照林社 2000
  • 肺動脈圧モニタリング
    ()
    クリティカルケアマニュアル,照林社 2000
  • 肺動脈カテーテル挿入
    ()
    クリティカルケアマニュアル,照林社 2000
  • 観血的動脈圧モニタリング
    ()
    クリティカルケアマニュアル,照林社 2000
  • 中心静脈圧モニタリング
    ()
    クリティカルケアマニュアル,照林社 2000
  • 中心静脈カニュレーション
    ()
    クリティカルケアマニュアル,照林社 2000
  • 末梢静脈カニュレーション
    ()
    クリティカルケアマニュアル,照林社 2000
  • プロポフォールの長期投与と日内変動について
    ()
    実践プロポフォール鎮静Q&A,メディカス(株) 2000
  • クリティカルケアと生体侵襲理論
    ()
    クリティカルケアマニュアル,照林社 2000
  • COPDにおける人工呼吸管理.
    ()
    新版 人工呼吸療法 -各種人工呼吸器の特徴・適応・保守管理-,秀潤社 1996
  • モニタリング.(共著)
    ()
    最新麻酔科学改訂第2版,克誠堂出版 1995
  • 代謝性(非呼吸性)アルカローシス.
    ()
    クリティカルケア・マニュアル 集中治療管理指針,秀潤社 1995
  • 代謝性(非呼吸性)アシドーシス.
    ()
    クリティカルケア・マニュアル 集中治療管理指針,秀潤社 1995
  • 肝不全患者での薬の使い方.
    ()
    研修医のための麻酔科領域薬剤の使い方,克誠堂出版 1995

Works

  • 呼吸管理の実際と最近の話題
    2005
  • 敗血症性ARDSに対するETX吸着療法の意義
    2005
  • 集中治療と総合医学
    2005
  • 菌血症とカテーテル敗血症の起因菌の変遷
    2005
  • 集中治療部の日常業務
    2003
  • 集中治療の実際.
    2002
  • 看護に生かす輸液ライン管理とモニタリングの知識.
    2002
  • 人工呼吸中の睡眠を考える -日内リズム(体内時計)の重要性
    2001
  • 特別講演 人工呼吸中の睡眠を考える-日内リズム(体内時計)の重要性
    2000
  • 痛みの基礎知識と対処法.
    1998
  • Permissive Hypercapnia.
    1997
  • ARDS(成人呼吸窮迫症候群)の概念
    1995
  • ARDSの概念・発生機序と新薬開発のポイント
    1995
  • 血液ガスの基礎と臨床 酸塩基平衡の実際
    1992

MISC

  • 鯉沼 俊貴, 布宮 伸, 和田 政彦  麻酔  61-  (2)  170  -176  2012/02  [Not refereed][Not invited]
  • 田中 進一郎, 布宮 伸, 和田 政彦  ICUとCCU : 集中治療医学  35-  (12)  1111  -1116  2011/12  [Not refereed][Not invited]
  • TANAKA Shinichiro, NUNOMIYA Shin, WADA Masahiko, MISAWA Kazuhide, KOINUMA Toshitaka, KOYAMA Kansuke  日本集中治療医学会雑誌 = Journal of the Japanese Society of Intensive Care Medicine  18-  (4)  617  -622  2011/10  [Not refereed][Not invited]
  • 田中 進一郎, 布宮 伸  Japanese journal of intensive care medicine  35-  (7)  553  -559  2011/07  [Not refereed][Not invited]
  • 小山 寛介, 布宮 伸  Japanese journal of intensive care medicine  35-  (7)  585  -588  2011/07  [Not refereed][Not invited]
  • 鯉沼 俊貴, 布宮 伸  Japanese journal of intensive care medicine  35-  (6)  503  -506  2011/06  [Not refereed][Not invited]
  • 布宮 伸, 貝沼 関志  日本臨床麻酔学会誌 = The Journal of Japan Society for Clinical Anesthesia  31-  (3)  2011/05  [Not refereed][Not invited]
  • 鯉沼 俊貴, 布宮 伸  Japanese journal of intensive care medicine  35-  (5)  423  -426  2011/05  [Not refereed][Not invited]
  • 小山 寛介, 布宮 伸  The Japanese journal of acute medicine  35-  (4)  379  -383  2011/04  [Not refereed][Not invited]
  • 田中 進一郎, 布宮 伸  Japanese journal of intensive care medicine  35-  (4)  337  -339  2011/04  [Not refereed][Not invited]
  • 小山 寛介, 布宮 伸  Japanese journal of intensive care medicine  35-  (3)  253  -255  2011/03  [Not refereed][Not invited]
  • Yoshinori Hosoya, Takashi Ui, Kentaro Kurashina, Hidenori Haruta, Shin Saito, Toru Zuiki, Masanobu Hyodo, Kiichi Sato, Norihiro Yamamoto, Kentaro Sugano, Michitaka Nagase, Hirohumi Hujii, Chiaki Shibayama, Masanori Nakazawa, kazuhide Misawa, Masahiko Wada, Shin Nunomiya, Yoshihiro Hirabayashi, Hiroshi Nishino, Kunio Miyazaki, Shunji Sarukawa, Noriyoshi Fukushima, Toshiro Niki, Kaichiro Tanba, Naohiro Sata, Hideo Nagai, Yoshikazu Yasuda  Jichi Medical University journal  33-  29  -36  2011/03  [Not refereed][Not invited]
     
    Jichi Medical University Hospital from 1999 through 2009 were reviewed. Long-term outcome, prognosis, and postoperative complications were analyzed. Multi-modality treatment regimens, including surgery, varied over three time intervals for patients with advanced cancer: 1) 1999-2006, preoperative chemo-radiotherapy: low-dose 5FU (300 mg/m2) and cisplatin (3 mg/m2) days 1-5/three courses with concurrent radiotherapy (40 Gy); 2) 2006-2007, postoperative standard FP chemotherapy: 5FU (800 mg/m2) day 1 and cisplatin (80 mg/m2) days 1-5/two courses; and 3) 2008-2009, preoperative chemotherapy: standard FP/two courses. The 3-year cumulative survival rate was calculated using the Kaplan-Meier method for each stage: Stage 0, 86% (n=25); Stage I, 91% (n=54); Stage II, 79% (n=94); Stage III, 56% (n=106); and Stage IV, 11% (n=38). Postoperative complications included respiratory failure (6%) and anastomotic leakage (4%). The hospital mortality rate was 0.6%. The present multi-modality regimen, with surgery before or after chemotherapy, radiotherapy, or both, is inadequate to improve outcomes for patients with advanced esophageal carcinoma. However, there is a need for advanced staging to develop more effective multidisciplinary treatment regimens.
  • 田中 進一郎, 布宮 伸  Japanese journal of intensive care medicine  35-  (2)  175  -177  2011/02  [Not refereed][Not invited]
  • 小山 寛介, 布宮 伸  Japanese journal of intensive care medicine  35-  (1)  93  -95  2011/01  [Not refereed][Not invited]
  • 布宮 伸  レジデントノ-ト  12-  (11)  1908  -1917  2010/11  [Not refereed][Not invited]
  • TANAKA Shinichiro, NUNOMIYA Shin, WADA Masahiko, MISAWA Kazuhide, KOINUMA Toshitaka, KOYAMA Kansuke  日本集中治療医学会雑誌 = Journal of the Japanese Society of Intensive Care Medicine  17-  (4)  525  -530  2010/10  [Not refereed][Not invited]
  • 布宮 伸  The Japanese journal of acute medicine  34-  (10)  1346  -1352  2010/09  [Not refereed][Not invited]
  • TANAKA Shinichiro, NUNOMIYA Shin, WADA Masahiko, MISAWA Kazuhide, KOINUMA Toshitaka, KOYAMA Kansuke, YUMOTO Ayano  日本集中治療医学会雑誌 = Journal of the Japanese Society of Intensive Care Medicine  17-  (3)  333  -337  2010/07  [Not refereed][Not invited]
  • 小山 寛介, 布宮 伸, 和田 政彦  Japanese journal of intensive care medicine  34-  (6)  461  -468  2010/06  [Not refereed][Not invited]
  • 田中 進一郎, 布宮 伸, 和田 政彦  Japanese journal of intensive care medicine  34-  (4)  329  -334  2010/04  [Not refereed][Not invited]
  • KOYAMA Kansuke, NUNOMIYA Shin, WADA Masahiko, MISAWA Kazuhide, TANAKA Shinichiro, KOINUMA Toshitaka  日本集中治療医学会雑誌 = Journal of the Japanese Society of Intensive Care Medicine  17-  (2)  163  -172  2010/04  [Not refereed][Not invited]
  • TANAKA Shinichiro, NUNOMIYA Shin, WADA Masahiko, MISAWA Kazuhide, KOINUMA Toshitaka, KOYAMA Kansuke, MIZUTA Koichi, YASUDA Yoshikazu  日本集中治療医学会雑誌 = Journal of the Japanese Society of Intensive Care Medicine  17-  (1)  43  -48  2010/01  [Not refereed][Not invited]
  • 小山 寛介, 布宮 伸  The Japanese journal of acute medicine  33-  (13)  1817  -1820  2009/12  [Not refereed][Not invited]
  • 田中 進一郎, 布宮 伸, 和田 政彦  Japanese journal of intensive care medicine  33-  (6)  503  -508  2009/06  [Not refereed][Not invited]
  • 田中 進一郎, 布宮 伸, 鯉沼 俊貴, 小山 寛介, 湯本 絢乃  Shock : 日本Shock学会雑誌  23-  (1)  2008/04  [Not refereed][Not invited]
  • 布宮 伸  救急医学  30-  (7)  840  -844  2006/07  [Not refereed][Not invited]
  • 田中 進一郎, 布宮 伸  Shock : 日本Shock学会雑誌  21-  (1)  2006/04  [Not refereed][Not invited]
  • 布宮 伸  呼吸器ケア  4-  (1)  79  -86  2006/01  [Not refereed][Not invited]
  • 鎮静・鎮痛対策
    呼吸器ケア  4-  (1:79-86)  2006  [Not refereed][Not invited]
  • 抜管したら呼吸管理は終了ですか?
    看護技術  51-  (14:1310-1311)  2005  [Not refereed][Not invited]
  • 抜管について教えてください
    看護技術  51-  (13:1226-1227)  2005  [Not refereed][Not invited]
  • ウィーニング中の観察ポイントについて教えてください
    看護技術  51-  (11:1002-1003)  2005  [Not refereed][Not invited]
  • 鎮痛・鎮静(共著)
    呼吸器ケア  3-  (10:1020-1026)  2005  [Not refereed][Not invited]
  • ウィーニングについて教えてください
    看護技術  51-  (10:914-915)  2005  [Not refereed][Not invited]
  • NPPVを成功させるコツはありますか?
    看護技術  51-  (9:828-829)  2005  [Not refereed][Not invited]
  • NPPVについて教えてください
    看護技術  51-  (8:738-739)  2005  [Not refereed][Not invited]
  • 肺保護戦略とは何ですか?
    看護技術  51-  (7:650-651)  2005  [Not refereed][Not invited]
  • 気管チューブの定期的な交換は必要ですか?
    看護技術  51-  (5:562-563)  2005  [Not refereed][Not invited]
  • 気管チューブの管理について教えてください
    看護技術  51-  (4:344-345)  2005  [Not refereed][Not invited]
  • グラフィックモニタはどう見ればいいのですか?
    看護技術  51-  (3:254-255)  2005  [Not refereed][Not invited]
  • カプノメータはどう使えばいいのですか?
    看護技術  51-  (2:166-167)  2005  [Not refereed][Not invited]
  • 症例とQ&Aで学ぶNPPV -適応,限界とそのEBM- 適応と開始時期,中止の判定法
    救急・集中治療  17-  (1:47-49)  2005  [Not refereed][Not invited]
  • カプノメータについて教えてください
    看護技術  51-  (1:76-77)  2005  [Not refereed][Not invited]
  • 不穏・せん妄に対する薬物療法(共著)
    看護技術  51-  (1:41-44)  2005  [Not refereed][Not invited]
  • クリティカルケアで不穏・せん妄,鎮痛・鎮静,抑制をどのように考えるか
    看護技術  51-  (1:11-14)  2005  [Not refereed][Not invited]
  • 自治医科大学ICUにおいてSivelestat sodium hydrateが投与された症例の検討(共著)
    臨床呼吸生理  37:9-13-  2005  [Not refereed][Not invited]
  • Protective lung strategyは有効である
    人工呼吸  22:146-  2005  [Not refereed][Not invited]
  • 二型糖尿病モデルであるGKラットのラ氏島におけるconnexin36(Cx36)の発現解析(共同研究)
    解剖学雑誌  80:s203-  2005  [Not refereed][Not invited]
  • 敗血症性RDSに対するエンドトキシン吸着療法による肺酸素化能改善機序の検討(共同研究)
    日集中医誌  12:s190-  2005  [Not refereed][Not invited]
  • 気道閉塞をきたした巨大縦隔腫瘍の一例(共同研究)
    日集中医誌  12:s182-  2005  [Not refereed][Not invited]
  • 布宮 伸  ICUとCCU  28-  (10)  839  -842  2004/10  [Not refereed][Not invited]
  • 布宮 伸, 大竹 一栄, 村田 克介, 和田 政彦  Shock : 日本Shock学会雑誌  19-  (1)  2004/04  [Not refereed][Not invited]
  • パルスオキシメータの使い方について教えてください
    看護技術  50-  (14:1300-1301)  2004  [Not refereed][Not invited]
  • Surviving Sepsis Campaign Guidelinesを巡って 血液製剤の投与
    ICUとCCU  28-  (10:839-842)  2004  [Not refereed][Not invited]
  • 持続鎮静と概日リズムについて教えてください
    看護技術  50-  (13:1220-1221)  2004  [Not refereed][Not invited]
  • 酸素を用いた心肺蘇生法
    酸素蘇生法テキスト:非医療従事者のための酸素を用いた心肺蘇生法,財団法人日本救急医療財団  39-51-  2004  [Not refereed][Not invited]
  • 人工呼吸中の鎮静薬投与について教えてください
    看護技術  50-  (11:1000-1001)  2004  [Not refereed][Not invited]
  • 人工呼吸中の精神的ケアと持続鎮静について教えてください
    看護技術  50-  (10:912-913)  2004  [Not refereed][Not invited]
  • 気管チューブの自己抜去を予防するにはどうすればいいのでしょうか?
    看護技術  50-  (9:824-825)  2004  [Not refereed][Not invited]
  • 気管吸引は閉鎖式が望ましいのですか?
    看護技術  50-  (8:736-737)  2004  [Not refereed][Not invited]
  • 人工呼吸管理中の気管吸引について教えてください
    看護技術  50-  (7:646-647)  2004  [Not refereed][Not invited]
  • 人工呼吸中の気道管理について教えてください
    看護技術  50-  (6:558-559)  2004  [Not refereed][Not invited]
  • 人工呼吸器の回路交換が不要というのは本当ですか?
    看護技術  50-  (4:340-341)  2004  [Not refereed][Not invited]
  • 人工呼吸器関連肺炎は予防できますか?
    看護技術  50-  (3:254-255)  2004  [Not refereed][Not invited]
  • 人工呼吸器関連肺炎はどうして起こるのでしょうか?
    看護技術  50-  (2:166-167)  2004  [Not refereed][Not invited]
  • 人工呼吸器のアラームへの対処について教えてください
    看護技術  50-  (1:74-75)  2004  [Not refereed][Not invited]
  • How does direct hemoperfusion with a polymyxin B immobilized column improve septic ARDS?
    Intensive Care Med  30:s109-  2004  [Not refereed][Not invited]
  • 診断・治療に困惑した多臓器不全の1例
    Shock  19:56-  2004  [Not refereed][Not invited]
  • 本学集中治療部におけるMRSA感染対策の現状と問題点 -新病棟の感染対策とその有効性-.(共同研究)
    日集中医誌  11:s184-  2004  [Not refereed][Not invited]
  • シベレスタットナトリウムが有効であった敗血症性ARDS 4症例.(共同研究)
    日集中医誌  11:s180-  2004  [Not refereed][Not invited]
  • 布宮 伸  呼吸器ケア  0-  (0)  202  -207  2003  [Not refereed][Not invited]
  • 人工呼吸の換気モードで,量規定や圧規定というのは何ですか?
    看護技術  49-  (14)  1302  -1303  2003  [Not refereed][Not invited]
  • トリガーとは何ですか?
    看護技術  49-  (13)  1218  -1219  2003  [Not refereed][Not invited]
  • PEEPを付加する方法と副作用について教えてください
    看護技術  49-  (11)  1004  -1005  2003  [Not refereed][Not invited]
  • PEEPとは何ですか?
    看護技術  49-  (10)  912  -913  2003  [Not refereed][Not invited]
  • 自発呼吸主体の換気モードについて教えてください
    看護技術  49-  (9)  824  -825  2003  [Not refereed][Not invited]
  • 主に呼吸管理の初期に用いられる換気モードについて教えてください
    看護技術  49-  (8)  736  -737  2003  [Not refereed][Not invited]
  • 人工呼吸の換気モードについて教えてください
    看護技術  49-  (7)  648  -649  2003  [Not refereed][Not invited]
  • 人工呼吸が生体に及ぼす影響について教えてください
    看護技術  49-  (6)  562  -563  2003  [Not refereed][Not invited]
  • 人工呼吸の適応となる酸素化能・換気能の障害以外の病態について教えてください
    看護技術  49-  (4)  344  -345  2003  [Not refereed][Not invited]
  • 換気能の障害と人工呼吸の適応は?
    看護技術  49-  (3)  256  -257  2003  [Not refereed][Not invited]
  • 酸素化能の障害と人工呼吸の適応は?
    看護技術  49-  (2)  168  -169  2003  [Not refereed][Not invited]
  • 人工呼吸とはどんなものですか?
    看護技術  49-  (1)  78  -79  2003  [Not refereed][Not invited]
  • 食道癌術後管理に対する新鮮凍結血漿投与の効果について(共同研究)
    日本臨床麻酔学会誌  23-  s429  2003  [Not refereed][Not invited]
  • 誤嚥における病態解析 -血中,肺水腫液中のサイトカイン動態-(共同研究)
    人工呼吸  20:181-  2003  [Not refereed][Not invited]
  • 人工呼吸管理を要した膠原病患者の検討(共同研究)
    Journal of Anesthesia  17-  s391  2003  [Not refereed][Not invited]
  • ICUにおける鎮痛・鎮静 プロポフォールの有用性
    Journal of Anesthesia  17-  s166  2003  [Not refereed][Not invited]
  • S. Nunomiya, S. Marukawa  Clinical Intensive Care  13-  (4)  167  -172  2002/12  [Not refereed][Not invited]
     
    Objective and design: Currently, Japan is facing a nationwide shortage of intensivists. To provide some answers on why such shortages exist, we conducted a survey by mailing a questionnaire to young Japanese Intensive Care certified anaesthesiologists, describing their daily practice and attitudes toward the ICU environment. Subjects: A total of 303 anaesthesiologists certified by the Japanese Society of Intensive Care Medicine (JSICM) from the year 1995 onward were evaluated of these, 175 were members of the Japan Society of Anesthesiologists and aged 45 years and below based on the JSICM database. Questionnaires were sent to these 175 anaesthesiologist-intensivists with 90 responses (51.4%) returned. Main results: Of the anaesthesia-based respondents (n=66), only 21.5% were practicing mainly as an intensivist while 87.5% of ICU-based respondents (n=24) were practicing as an intensivist. The remaining 12.5% were practicing mainly as an anaesthetist. This gave a total of only 38.9% of the respondents practicing as intensivists in ICUs. We also found very low ICU participation rates among the anaesthesiologists, particularly in departments who have chairpersons less enthusiastic toward ICU. Conclusions: Although all respondents in this survey were certified by JSICM, only a small percentage actually practiced ICU full-time but also many "intensive-care-certified" anaesthesiologists did not function as ICU attending staffs. Some of the factors identified for such dismal findings were manpower shortage, lack of appreciation and recognition of intensivists, and insufficient employment opportunities outside the university or teaching hospitals. It was further noted that enthusiasm for ICU work among the respondents paralleled closely their senior consultants' own enthusiasm for ICU.
  • 布宮 伸  エキスパートナース  18-  (7)  20  -23  2002/06  [Not refereed][Not invited]
  • 布宮 伸  ハートナーシング  15-  (3)  310  -315  2002/03  [Not refereed][Not invited]
  • 看護に生かす輸液ライン管理とモニタリングの知識.
    Expert Nurse  18-  (12)  102  2002  [Not refereed][Not invited]
  • 人工呼吸中の“睡眠”について考える -概日リズム(体内時計)の重要性-.
    Expert Nurse  18-  (7)  20  -23  2002  [Not refereed][Not invited]
  • 急性期における鎮静・鎮痛薬.
    HEART nursing  15-  (3)  310  -315  2002  [Not refereed][Not invited]
  • 鎮静深度に日内変動をつけることの重要性.
    Human Contact  10: 3-  2002  [Not refereed][Not invited]
  • 食道癌術後患者における,血液中のエンドトキシンとβグルカン値の検討 -食道癌術後に高エンドトキシン血症をきたすか?-(共同研究)
    Journal of Anesthesia  16-  s269  2002  [Not refereed][Not invited]
  • 人工呼吸管理が必要となった百日咳肺炎 -3症例の検討-(共同研究)
    日本集中治療医学会雑誌  9-  s127  2002  [Not refereed][Not invited]
  • 布宮 伸  救急医学  25-  (9)  1003  -1009  2001/09  [Not refereed][Not invited]
  • 布宮 伸, 大江 恭司, 百瀬 和子, 窪田 達也, 大竹 一栄, 村田 克介, 和田 政彦, 丹野 英  日本臨床麻酔学会誌 = The Journal of Japan Society for Clinical Anesthesia  21-  (2)  94  -98  2001/03  [Not refereed][Not invited]
  • 酸素運搬とその周辺.
    救急医学  25-  (9)  1003  -1009  2001  [Not refereed][Not invited]
  • プロポフォールによる鎮静が概日リズムに与える影響について -終日投与と間欠的持続投与の比較-(共同研究)
    Journal of Anesthesia  15-  s72  2001  [Not refereed][Not invited]
  • 布宮 伸, 大江 恭司, 百瀬 和子, 窪田 達也, 大竹 一栄, 村田 克介, 和田 政彦, 丹野 英  日本臨床麻酔学会誌  21-  (2)  94  -98  2001  [Not refereed][Not invited]
  • ICUでの鎮静・ミダゾラムとプロポフォール -プロポフォール派の立場から
    pharmacoanesthesiology  12-  (2)  61  -64  2000  [Not refereed][Not invited]
  • プロポフォールによる夜間鎮静が概日リズムに与える影響.(共著)
    ICUとCCU  24-  (11)  837  -841  2000  [Not refereed][Not invited]
  • 丹野 英, 大江 恭司, 布宮 伸, 村田 克介, 大竹 一栄, 窪田 達也  日本臨床麻酔学会誌  20-  (7)  449  -453  2000  [Not refereed][Not invited]
  • プロポフォールによる長時間の鎮静が血中脂質と細胞性免疫に与える影響 -持続鎮静と間欠的持続投与の比較-(共同研究)
    日本臨床麻酔学会誌  20-  s384  2000  [Not refereed][Not invited]
  • 人工呼吸下の患者の夜間睡眠補助薬としてのプロポフォールの反復投与の効果
    人工呼吸  17-  (2)  150  2000  [Not refereed][Not invited]
  • 「より良い鎮静・鎮痛を目指して-鎮静深度調節の重要性を考える-」
    Human Contact  5-  4  2000  [Not refereed][Not invited]
  • 術後肺梗塞にたいするt-PAの至適投与法の検討(共同研究)
    Journal of Anesthesia  14-  s100  2000  [Not refereed][Not invited]
  • 新世紀にのぞむ集中治療 若年専門医の期待と展望.
    Journal of Anesthesia  14-  s41  2000  [Not refereed][Not invited]
  • プロポフォールによる長期間の夜間鎮静が血中脂質と細胞性免疫に与える影響(共同研究)
    Journal of Anesthesia  14-  s37  2000  [Not refereed][Not invited]
  • ICUにおける人工呼吸療法下の夜間睡眠補助薬としてのプロポフォールの反復投与の効果
    日本集中治療医学会雑誌  7-  s148  2000  [Not refereed][Not invited]
  • NOはARDS症例での肺酸素化能を改善するか-メタ分析による検討(共同研究)
    日本集中治療医学会雑誌  7-  s143  2000  [Not refereed][Not invited]
  • 多臓器不全の基礎と臨床 多臓器不全をいかに予防するか
    Medical Practice  17-  (2)  263  -266  2000  [Not refereed][Not invited]
  • ICU患者の睡眠障害と概日リズム;ICUにおける日内変動をつけた鎮静法と血清メラトニンの変動
    ICUとCCU  24-  (6)  407  -412  2000  [Not refereed][Not invited]
  • 中村 豪, 窪田 達也, 布宮 伸, 大竹 一栄, 村田 克介, 和田 政彦, 松山 尚弘, 百瀬 和子, 宮地 圭祐, 猪狩 典俊  Shock : 日本Shock学会雑誌  14-  (1)  1999/04  [Not refereed][Not invited]
  • アマニタトキシン群毒キノコ中毒(ア群毒キノコ中毒)6症例の検討(共同研究)
    日本救急医学会雑誌  10-  (9)  554  1999  [Not refereed][Not invited]
  • 調節換気中の吸気呼吸抵抗値の周波数特性(共同研究)
    人工呼吸  16-  (2)  185  1999  [Not refereed][Not invited]
  • 肝硬変合併肝悪性腫瘍に対する拡大肝切除術の周術期管理
    日本臨床麻酔学会誌  19-  (8)  s131  1999  [Not refereed][Not invited]
  • アマトキシン類きのこ中毒による3症例の比較検討(共同研究)
    日本臨床麻酔学会誌  19-  (8)  s155  1999  [Not refereed][Not invited]
  • 低カリウム血症による心肺停止の一例(共同研究)
    蘇生  18-  (3)  195  1999  [Not refereed][Not invited]
  • Sepsis and DIC: Role of antithrombin III replacement therapy. -Significance of plasminogen activator inhibitor-1 and antithrombin III activity in patients with sepsis-.(共同研究)
    Acta Anaesthesiologica Sinica  37-  s23  1999  [Not refereed][Not invited]
  • ICUにおけるHRV(heart rate variability)の有用性 -脳組織傷害と持続鎮静時との比較-(共同研究)
    Journal of Anesthesia  13-  s283  1999  [Not refereed][Not invited]
  • 頚椎前方固定術後に挿入骨片によりspinal shockを呈した1症例(共同研究)
    Journal of Anesthesia  13-  s218  1999  [Not refereed][Not invited]
  • 分娩後に発症した産科的ショックの2例(共同研究)
    Shock  14-  (1)  71  1999  [Not refereed][Not invited]
  • CHDF中の抗生剤の血中濃度に関する考察(共同研究)
    日本集中治療医学会雑誌  6-  s162  1999  [Not refereed][Not invited]
  • 救命が因難であった呼吸不全症の検討(共同研究)
    日本集中治療医学会雑誌  6-  s122  1999  [Not refereed][Not invited]
  • 敗血症患者における血管内皮障害の指標としての血中トロンボモジュリンの変動と臓器障害 -AT-III補充療法の効果-.
    日本集中治療医学会雑誌  6-  s115  1999  [Not refereed][Not invited]
  • 本学集中治療部におけるMRSA感染対策の現状と問題点(共同研究)
    日本集中治療医学会雑誌  6-  s116  1999  [Not refereed][Not invited]
  • A prospective study of plasma procalcitonin for monitoring critically ill patients in general ICU.
    Intensive Care Medicine  25-  s75  1999  [Not refereed][Not invited]
  • A prospective study of plasma procalcitonin for monitoring critically ill patients in general ICU
    Intensive Care Medicine  25-  s75  1999  [Not refereed][Not invited]
  • 食道癌術後の呼吸管理 サイトカインとステロイド投与について.(共著)
    臨床呼吸生理  30-  15  -18  1998  [Not refereed][Not invited]
  • 術前または術直後のステロイド単回投与の食道癌術後管理における有用性について.(共著)
    ICUとCCU  22-  367  -373  1998  [Not refereed][Not invited]
  • 頭蓋咽頭腫全摘出術後に発症した激烈な横紋筋融解症の1症例(共著)
    日本集中治療医学会雑誌  5-  (3)  217  -220  1998  [Not refereed][Not invited]
  • 集中治療中の合併症 血液・凝固障害
    ICUとCCU  22-  (12)  917  -923  1998  [Not refereed][Not invited]
  • 救急・応急のための基本手技 人工呼吸法(共著)
    Medical Practice  15-  206  -214  1998  [Not refereed][Not invited]
  • 集中治療領域における最新の医療機器.(共著)
    学会新報  19-  5  -9  1998  [Not refereed][Not invited]
  • 「法に規定する脳死判定」の無呼吸テストの実施にあたっての問題点(共同研究)
    蘇生  17-  206  1998  [Not refereed][Not invited]
  • 本院ICUにおける経皮的心肺補助装置(PCPS)の使用状況と問題点(共同研究)
    蘇生  17-  184  1998  [Not refereed][Not invited]
  • Significances of Plasminogen Activator Inhibitor-1 and Antithrombin III Activity in patients with sepsis: Effect of Antithrombin III Replacement Therapy on Plasminogen Activotor Inhibitor-1 Concentration.(共同研究)
    1998  [Not refereed][Not invited]
  • Plasma thrombomodulin in patients with sepsis.
    1998  [Not refereed][Not invited]
  • 敗血症患者における血中トロンボモジュリンの変動
    ICUとCCU  22-  (9)  663  -668  1998  [Not refereed][Not invited]
  • 敗血症におけるantithrombinIIIとplasminogen activator inhibitor-1の変動
    日本臨床麻酔学会誌  18-  (1)  33  -36  1998  [Not refereed][Not invited]
  • Significances of plasminogen activator inhibitor-1 and antithrombin III activity in patients with sepsis: Effect of antithrombin III replacement therapy on plasminogen activator inhibitor-1 concentration.
    1998  [Not refereed][Not invited]
  • Plasma thrombomodulin in patients with sepsis.
    1998  [Not refereed][Not invited]
  • OE Kyoji, MURATA Katsusuke, KUBOTA Tatsuya, OTAKE Kazuei, NUNOMIYA Sin, WADA Masahiko  日本集中治療医学会雑誌 = Journal of the Japanese Society of Intensive Care Medicine  4-  (3)  207  -213  1997/07  [Not refereed][Not invited]
  • 自治医科大学ICUにおける農薬中毒治療の経験.(共著)
    集中治療  9-  475  -477  1997  [Not refereed][Not invited]
  • 食道癌症例における術直後のステロイド単回投与の術後管理における有用性について-血漿サイトカインの変動からの検討-(共著)
    日本集中治療医学会雑誌  4-  (3)  207  -213  1997  [Not refereed][Not invited]
  • Inflammatory cytokines and multiple organ dysfunction syndrome in septic patients. -which organ is initially affected?(共同研究)
    1997  [Not refereed][Not invited]
  • Time courses of plasminogen activator inhibitor-1 and antithrombin III in patients with sepsis: The role of antithrombin III replacement therapy.
    1997  [Not refereed][Not invited]
  • 敗血症における血中トロンボモジュリンの変動
    日本集中治療医学会雑誌  4-  S199  1997  [Not refereed][Not invited]
  • The role of antithrombin III replacement therapy.
    Bulletin of Intensive and Critical Care  4-  (3)  9  -12  1997  [Not refereed][Not invited]
  • The role of antithrombin III replacement therapy.
    Bulletin of Intensive and Critical Care  4-  (3)  9  -12  1997  [Not refereed][Not invited]
  • Time courses of plasminogen activator inhibitor-1 and antithrombin III in patients with sepsis : The role of antithrombin III replacement therapy.
    1997  [Not refereed][Not invited]
  • Shin Nunomiya, Toshihide Tsujimoto, Masaru Tanno, Naohiro Matsuyama, Kazuei Ohtake, Tatsuya Kubota  Journal of Anesthesia  10-  (3)  163  -169  1996/09  [Not refereed][Not invited]
     
    The present study was designed to evaluate a new continuous intraarterial blood gas monitoring system under routine clinical intensive care conditions. Nine mechanically ventilated adult patients were enrolled in this study. A multiparameter intravascular sensor was inserted into the radial or dorsalis pedis artery through a 20-gauge cannula in each patient. The accuracy of the sensor for pH, Pco2, and Po2 values was evaluated by comparing the data simultaneously obtained from the monitoring system and from conventional blood gas analysis. Measurements were performed for 3 days for each sensor. A total of 62 blood samples were obtained for comparison. The ranges of measured variables were: pH 7.185-7.602, Pco2, 28.8-68.5 mmHg, and Po2 45.2-542.4 mmHg. The overall bias ±precision values were 0.002±0.018 for pH units, 0.53±2.04mmHg for Pco2, and -1.62±20.00 mmHg for Po2. In clinically important ranges of Po2, less than 200 mmHg in particular, the bias and precision values were -2.25±6.48 mmHg in the range of less than 100mmHg, and 0.98±14.38 mmHg in the range of 100-200 mmHg. Variations of sensor accuracy as a function of elapsed time were within the clinically acceptable range throughout the study period. These findings suggest that this new device is sufficiently useful for routine clinical settings. © 1996 JSA.
  • Shin Nunomiya, Toshihide Tsujimoto, Masaru Tanno, Naohiro Matsuyama, Kazuei Ohtake, Tatsuya Kubota  Journal of Anesthesia  10-  (3)  163  -169  1996/09  [Not refereed][Not invited]
     
    The present study was designed to evaluate a new continuous intraarterial blood gas monitoring system under routine clinical intensive care conditions. Nine mechanically ventilated adult patients were enrolled in this study. A multiparameter intravascular sensor was inserted into the radial or dorsalis pedis artery through a 20-gauge cannula in each patient. The accuracy of the sensor for pH, Pco2, and Po2 values was evaluated by comparing the data simultaneously obtained from the monitoring system and from conventional blood gas analysis. Measurements were performed for 3 days for each sensor. A total of 62 blood samples were obtained for comparison. The ranges of measured variables were: pH 7.185-7.602, Pco2, 28.8-68.5 mmHg, and Po2 45.2-542.4 mmHg. The overall bias ±precision values were 0.002±0.018 for pH units, 0.53±2.04mmHg for Pco2, and -1.62±20.00 mmHg for Po2. In clinically important ranges of Po2, less than 200 mmHg in particular, the bias and precision values were -2.25±6.48 mmHg in the range of less than 100mmHg, and 0.98±14.38 mmHg in the range of 100-200 mmHg. Variations of sensor accuracy as a function of elapsed time were within the clinically acceptable range throughout the study period. These findings suggest that this new device is sufficiently useful for routine clinical settings. © 1996 JSA.
  • 敗血症におけるplasminogen activator inhibitor-1(PAI-1)とantithrombinIII(AT-III)の変動
    日本臨床麻酔学会誌  16-  S121  1996  [Not refereed][Not invited]
  • 誤嚥性肺炎における血中,肺胞中サイトカインと多臓器不全との関係(共同研究)
    日本集中治療医学会雑誌  3-  S184  1996  [Not refereed][Not invited]
  • 敗血症性肺障害(Septic ARDS)とサイトカインとの相関について(共同研究)
    日本集中治療医学会雑誌  3-  S137  1996  [Not refereed][Not invited]
  • 敗血症性DIC患者における血中AT-III値とPAI-1濃度の変動
    日本集中治療医学会雑誌  3-  S180  1996  [Not refereed][Not invited]
  • こんな症例.こんな画像
    集中治療  8-  (7)  701  1996  [Not refereed][Not invited]
  • こんな症例,こんな画像
    集中治療  8-  (4)  349  1996  [Not refereed][Not invited]
  • IMV,PSVウィニングにおける呼吸筋エネルギー消費の比較検討(共同研究)
    人工呼吸  12-  (2)  206  1995  [Not refereed][Not invited]
  • 自治医科大学ICUで経験した破傷風4例の検討.(共著)
    ICUとCCU  19-  435  -439  1995  [Not refereed][Not invited]
  • 血管内血液ガス連続モニタリングシステム パラトレンド7の臨床的精度について
    人工呼吸  12-  (2)  236  1995  [Not refereed][Not invited]
  • パラコート中毒
    臨床医  21-  (7)  1819  -1822  1995  [Not refereed][Not invited]
  • 完全静脈栄養中の代謝性アシドーシス
    月刊地域医学  9-  (5)  328  -331  1995  [Not refereed][Not invited]
  • 透過性亢進型肺水腫により死亡した全身性エリテマトーデスの1例
    ICUとCCU  19-  (4)  357  -361  1995  [Not refereed][Not invited]
  • 急性肺傷害スコア分類による末梢血顆粒球の活性酸素種産生能(共同研究)
    Journal of Anesthesia  9-  S435  1995  [Not refereed][Not invited]
  • 敗血症性臓器障害と血中サイトカイン
    Shock  10-  (1)  31  1995  [Not refereed][Not invited]
  • 敗血症におけるサイトカインの変動と臓器障害
    Journal of Anesthesia  9-  S235  1995  [Not refereed][Not invited]
  • 血管内血液ガス連続モニタリングシステム パラトレンド7の精度について.
    臨床モニター  6-  S51  1995  [Not refereed][Not invited]
  • 当施設の血液浄化法の現状と評価(共同研究)
    日本集中治療医学会雑誌  2-  S206  1995  [Not refereed][Not invited]
  • カーディオフローによる持続血奨交換の試み(共同研究)
    日本集中治療医学会雑誌  2-  S205  1995  [Not refereed][Not invited]
  • 薬剤性顆粒球減少症におけるG-CSF使用下での活性酸素種産生能 -症例報告-(共同研究)
    日本集中治療医学会雑誌  2-  S147  1995  [Not refereed][Not invited]
  • 敗血症における末梢血顆粒球の活性酸素種産生能 -fMLP刺激による比較-(共同研究)
    日本集中治療医学会雑誌  2-  S144  1995  [Not refereed][Not invited]
  • 動脈内連続血液ガスモニター パラトレンド7とPB3300の比較検討
    日本集中治療医学会雑誌  2-  S189  1995  [Not refereed][Not invited]
  • 集中治療管理を要した膠原病患者の検討
    日本集中治療医学会雑誌  2-  S129  1995  [Not refereed][Not invited]
  • 超小型ポータブル血液分析器(i-STAT)の動脈血液における有用性について(共同研究)
    臨床モニター  5-  (増)  133  -134  1994  [Not refereed][Not invited]
  • Prognostic diagnosis of aspiration pneumonia based on the degree of peripheral leukocyte reduction.(共同研究)
    1994  [Not refereed][Not invited]
  • ARDSに対するサーファクタント補充療法の治療経験(共同研究)
    日本集中治療医学会雑誌  1-  S131  1994  [Not refereed][Not invited]
  • 呼吸不全における胸部CTの有用性と問題点
    日本集中治療医学会雑誌  1-  S94  1994  [Not refereed][Not invited]
  • 末梢血白血球数による誤嚥性肺炎の重症度評価(共同研究)
    Journal of Anesthesia  8-  (S8)  295  1994  [Not refereed][Not invited]
  • 低ナトリウム血症による意識障害4例の検討(共同研究)
    日本集中治療医学会雑誌  1-  S207  1994  [Not refereed][Not invited]
  • ショック
    看護技術  40-  (2(増))  129  -132  1994  [Not refereed][Not invited]
  • Septic ARDS-病態に関する最近の考え方と治療法-.
    集中治療  6-  (2)  169  -180  1994  [Not refereed][Not invited]
  • 集中治療室における連続血管内動脈血液ガスモニターの適用について(共同研究)
    臨床モニター  5-  S136  1994  [Not refereed][Not invited]
  • ICU入室患者における連続心拍出量測定システム(CCOM)の使用経験-第2報-.(共同研究)
    臨床モニター  4-  (増)  46  1994  [Not refereed][Not invited]
  • 重症嚥下性肺炎の血行動態について(共同研究)
    蘇生  12-  S81  1993  [Not refereed][Not invited]
  • ICU症例におけるウリナスタチンの有効性-分割投与法と特続投与法との比較-.(共同研究)
    日本臨床麻酔学会誌  13-  255  1993  [Not refereed][Not invited]
  • 薬剤性骨髄抑制による好中球減少症に対するG-CSFの効果(共同研究)
    ICUとCCU  17-  (増)  264  1993  [Not refereed][Not invited]
  • メシル酸ナファモスタットによる高カリウム血症に代謝性アシドーシスを合併した2例(共同研究)
    ICUとCCU  17-  (増)  254  1993  [Not refereed][Not invited]
  • DIC及びpre-DIC患者におけるNafamostat mesilateの血中濃度(共同研究)
    ICUとCCU  17-  (増)  247  1993  [Not refereed][Not invited]
  • 薬剤性高ビリルビン血症に対するステロイド・パルス療法(共同研究)
    ICUとCCU  17-  (増)  253  1993  [Not refereed][Not invited]
  • 上腹部手術後の呼吸不全における胸壁コンプライアンスの意義(共同研究)
    麻酔  42-  S111  1993  [Not refereed][Not invited]
  • 横紋筋隔解症の2症例(共同研究)
    日本臨床麻酔学会誌  13-  457  1993  [Not refereed][Not invited]
  • MRSAおよび緑膿菌の混合感染により肺炎,膿胸を併発して入院した1症例(共同研究)
    ICUとCCU  17-  (増)  265  1993  [Not refereed][Not invited]
  • 片肺患者における肺高血圧症と術後呼吸不全(共著)
    臨床呼吸生理  25-  29  -35  1993  [Not refereed][Not invited]
  • CHF用ダイアライザーにおけるNafamostat mesilate(FUT)の吸着性の検討(共著)
    集中治療  5-  (別)  129  -130  1993  [Not refereed][Not invited]
  • ユーザーレポート アコマ人工呼吸器ART-1000と呼吸終末陽圧装置CF-PEEPの組合せ
    人工呼吸  10-  (2)  258  1993  [Not refereed][Not invited]
  • 特集 ハイテク集中治療の課題 人工呼吸器-過去・現在・未来
    新医療  20-  (2)  87  -89  1993  [Not refereed][Not invited]
  • 小児意識障害に対するglycerol療法中の高Na血症.
    蘇生  11,96-  1993  [Not refereed][Not invited]
  • 低体温麻酔時の酸塩基操作(共著)
    山形医学  10-  (2)  143  -155  1992  [Not refereed][Not invited]
  • 呼吸不全-ベッドサイドマネージメント 陽圧呼吸管理中の合併症
    診断と治療  80-  (11)  2118  -2123  1992  [Not refereed][Not invited]
  • 特集 慢性閉塞性肺疾患の急性増悪 機械的呼吸管理(共著)
    ICUとCCU  16-  (8)  719  -728  1992  [Not refereed][Not invited]
  • 抗生剤が原因と考えられる薬剤性骨髄抑制をG-CSF併用により治癒しえた1症例(共同研究)
    日本臨床麻酔学会誌  12-  s295  1992  [Not refereed][Not invited]
  • 透過性亢進型肺水腫に対しステロイドパルス療法とウリナスタチンとの大量投与が著効した1例(共同研究)
    日本臨床麻酔学会誌  12-  s387  1992  [Not refereed][Not invited]
  • 布宮 伸, 堀川 秀男, 酒井 道子  日本臨床麻酔学会誌  11-  (5)  580  -590  1991  [Not refereed][Not invited]
  • 麻酔導入後に頻脈・呼吸性アシドーシス・ミオグロビン尿症を認めた1例.(共著)
    麻酔と蘇生  26,83-87-  1990  [Not refereed][Not invited]
  • CPPV時の循環系の変動に及ぼす脱水の影響-利尿による急性脱水と絶食による亜急性脱水の比較-
    麻酔  38,S546-  1989  [Not refereed][Not invited]
  • 向精神薬による悪性症候群の一重症例(共著)
    麻酔と蘇生  25-  (4)  399  -404  1989  [Not refereed][Not invited]
  • Inversed ratio ventilationが開心術後のガス交換に及ぼす影響(共著)
    人工呼吸  6,102-106-  1989  [Not refereed][Not invited]
  • 頸動脈洞過敏症候群の麻酔経験
    日本臨床麻酔学会誌  8-  s125  1988  [Not refereed][Not invited]
  • Bartter症候群の麻酔経験.
    麻酔  37,1557-  1988  [Not refereed][Not invited]
  • 長期人工呼吸を要した重症破傷風の2例(共著)
    ICUとCCU  12-  (12)  1105  -1110  1988  [Not refereed][Not invited]
  • 布宮 伸, 天笠 澄夫, 鏡 勲  日本臨床麻酔学会誌  8-  (4)  333  -338  1988  [Not refereed][Not invited]
  • CPPV時の循環系の変動に及ぼす脱水の影響―絶食による脱水状態―.
    麻酔  37,S192-  1988  [Not refereed][Not invited]
  • パンクロニウム前処置がサクシニルコリンの作用時間に及ぼす影響
    臨床麻酔  11-  (4)  453  -456  1987  [Not refereed][Not invited]
  • CPPV時の循環系の変動に及ぼす急性脱水の影響.
    麻酔  36,S355-  1987  [Not refereed][Not invited]
  • Nitroglycerinによる低血圧麻酔中の血液ガスの変化.
    山形県立病院医学雑誌  21-  (1)  1  -6  1987  [Not refereed][Not invited]
  • 全身麻酔患者の血漿膠質浸透圧.
    山形県立病院医学雑誌  20-  (1)  34  -39  1986  [Not refereed][Not invited]
  • 左右肺分離独立換気法の麻酔管理への応用.-その有用性と問題点-.(共著)
    山形県立病院医学雑誌  20-  (1)  26  -33  1986  [Not refereed][Not invited]
  • 低体温麻酔時の炭酸ガス分圧操作―循環動態への影響―.
    麻酔  34,S398-  1985  [Not refereed][Not invited]
  • Clinical Intensive Care  2002-  [Not refereed][Not invited]
     
    13/4,167-175

Research Grants & Projects

  • 人工呼吸下の至適鎮静
  • 敗血症性血液凝固・線溶障害
  • エンドトキシン肺障害
  • Coagulation and fibrinolytic disorders in sepsis
  • Endotoxin-induced lung injury


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