Researchers Database

matsumoto satohiro

    ComprehensiveMedicine1 Associate Professor
Last Updated :2021/12/04

Researcher Information

J-Global ID

Research Areas

  • Life sciences / Gastroenterology

Academic & Professional Experience

  • 2018/05 - Today  Saitama Medical Center, Jichi Medical University消化器内科准教授
  • 2014/04 - 2018/04  Jichi Medical University消化器科講師
  • 2008/04 - 2014/03  Jichi Medical University消化器科助教
  • 2003/05 - 2008/03  上五島病院
  • 2002/05 - 2003/04  Jichi Medical University後期臨床研修
  • 2001/05 - 2002/04  上対馬病院
  • 1999/05 - 2001/04  国立病院機構長崎医療センター初期臨床研修

Education

  • 1993/04 - 1999/03  Jichi Medical University  School of Medicine  医学科

Association Memberships

  • THE JAPANESE SOCIETY OF GASTROENTEROLOGICAL CANCER SCREENING   JAPAN GASTROENTEROLOGICAL ENDOSCOPY SOCIETY   JAPANESE SOCIETY OF GASTROENTEROLOGY   THE JAPANESE SOCIETY OF INTERNAL MEDICINE   

Published Papers

  • Shuhei Yoshikawa, Takeharu Asano, Mina Morino, Keita Matsumoto, Hitomi Kashima, Yudai Koito, Takaya Miura, Yuko Takahashi, Rumiko Tsuboi, Takehiro Ishii, Haruka Otake, Junichi Fujiwara, Masanari Sekine, Takeshi Uehara, Kazuhito Yuhashi, Satohiro Matsumoto, Shinichi Asabe, Hiroyuki Miyatani, Hirosato Mashima
    Scientific reports 11 (1) 3015 - 3015 2021/02 
    Pruritus is known to be a common complication in hepatitis patients, but the exact frequency and degree are not fully elucidated. Thus, we evaluated pruritus of 450 patients with chronic liver disease at our hospital. Pruritus was observed in 240 (53%) of the patients. Pruritus was significantly associated with males (OR = 1.51, P = 0.038) and patients with alkaline phosphatase (ALP) ≥ 200 U/L (OR = 1.56, P = 0.0495) and was significantly less in HBsAg-positive patients (OR = 0.449, P = 0.004). Seasonally, there was no difference in the frequency of pruritus between summer and winter. Of the 24 refractory pruritus patients treated with nalfurafine, 17 (71%) indicated improvement of itch, which is defined as a decrease in the visual analog scale score ≥ 30 mm. Pruritus was improved by nalfurafine both during daytime and nighttime in the Kawashima's scores evaluation. All patients who received nalfurafine exhibited improved Kawashima's scores ≥ 1 point during the daytime or nighttime. In conclusion, pruritus occurred in > 50% of patients with chronic liver disease, and predictors of pruritus were males and ALP ≥ 200 U/L. Nalfurafine may be useful for pruritus, regardless of whether daytime or nighttime.
  • AIDS治療中に抗酸菌による胃壁外腫瘤を合併した一例
    小島 柊, 浅野 岳晴, 賀嶋 ひとみ, 三浦 孝也, 松本 吏弘, 宮谷 博幸, 眞嶋 浩聡
    日本消化器病学会関東支部例会プログラム・抄録集 日本消化器病学会-関東支部 363回 26 - 26 2021/02
  • 小島 柊, 賀嶋 ひとみ, 石井 剛弘, 上原 健志, 浅野 岳晴, 松本 吏弘, 宮谷 博幸, 眞嶋 浩聡
    Progress of Digestive Endoscopy (一社)日本消化器内視鏡学会-関東支部 96 (1) 186 - 188 1348-9844 2020/06 
    70歳男性。発熱、悪寒および右季肋部痛を主訴とした。64歳時に胃癌(pStage IB)で胃全摘術(Roux-en Y再建術)を受けていた。血液検査でCRP値の軽度高値を認め、造影CTで肝S1に内部に隔壁を伴う被膜の厚い40mm大の嚢胞性病変を認めた。また、輸入脚から肝S1にかけて線状の高吸収域がみられた。以上より、輸入脚盲端異物の穿通による肝膿瘍と診断した。輸入脚盲端と肝臓は密着しており、ダブルバルーン内視鏡を用いて異物を摘出した。摘出した異物は長さ40mm、直径3mmの竹串であった。問診で3ヵ月前に泥酔状態で焼き鳥を串ごと摂取したことが判明した。術後はTAZ/PIPC投与を開始した。CRP値は低下したが、第8病日に40度台の発熱が出現し、経皮的ドレナージを施行した。その後、発熱なくCRP値が低下し、第14病日にドレーンを抜去した。第19病日に退院となり、退院後半年のCTで肝膿瘍の消失を認めた。
  • 幽門腺腺腫内に胃底腺型腺癌の合併が疑われた1例
    小島 柊, 田中 亨, 山田 茂樹, 秋元 真穂, 蛭田 昌宏, 土橋 洋, 三浦 孝也, 松本 吏弘, 眞嶋 浩聡
    日本病理学会会誌 (一社)日本病理学会 109 (1) 343 - 343 0300-9181 2020/03
  • A型肝炎の炎症改善後も黄疸遷延した1例
    小島 柊, 浅野 岳晴, 吉川 修平, 大竹 はるか, 藤原 純一, 関根 匡成, 上原 健志, 湯橋 一仁, 松本 吏弘, 宮谷 博幸, 眞嶋 浩聡
    埼玉県医学会雑誌 埼玉県医学会 54 (1) 220 - 223 0389-0899 2019/12 
    33歳男性。食欲不振、関節痛を主訴に前医を受診し、A型肝炎と診断された。診断後は保存的加療にて肝酵素の改善傾向を認めたが、ビリルビン上昇が遷延し、ステロイド内服なども改善に乏しいため、黄疸遷延の加療目的に当院へ転院となった。受診時、血液検査ではビリルビンは高値を示しており、ステロイドの増量やビリルビン吸着などを検討したが、自然経過中に、ビリルビンは低下傾向となり、ステロイドの内服を継続することで、その後もビリルビン値は低下し、患者は第19病日に軽快退院後、外来での経過観察となった。
  • 小島 柊, 賀嶋 ひとみ, 石井 剛弘, 森野 美奈, 松本 圭太, 小糸 雄大, 三浦 孝也, 高橋 裕子, 坪井 瑠美子, 吉川 修平, 大竹 はるか, 藤原 純一, 関根 匡成, 上原 健志, 浅野 岳晴, 松本 吏弘, 宮谷 博幸, 眞嶋 浩聡
    Progress of Digestive Endoscopy (一社)日本消化器内視鏡学会-関東支部 96 (Suppl.) s131 - s131 1348-9844 2019/12 [Refereed][Not invited]
  • A型肝炎の炎症改善後も、高度黄疸が遷延した1例
    小島 柊, 浅野 岳晴, 吉川 修平, 藤原 純一, 関根 匡成, 上原 健志, 湯橋 一仁, 松本 吏弘, 宮谷 博幸, 眞嶋 浩聡
    埼玉県医学会雑誌 埼玉県医学会 54 (1) np38 - np38 0389-0899 2019/12 [Refereed][Not invited]
  • A型肝炎の炎症改善後も黄疸遷延した1例
    小島 柊, 浅野 岳晴, 吉川 修平, 大竹 はるか, 藤原 純一, 関根 匡成, 上原 健志, 湯橋 一仁, 松本 吏弘, 宮谷 博幸, 眞嶋 浩聡
    埼玉県医学会雑誌 埼玉県医学会 54 (1) 220 - 223 0389-0899 2019/12 [Refereed][Not invited]
  • Shuhei Yoshikawa, Takeharu Asano, Mizuki Watanabe, Takehiro Ishii, Haruka Ohtake, Junichi Fujiwara, Masanari Sekine, Takeshi Uehara, Kohei Hamamoto, Kazuhito Yuhashi, Satohiro Matsumoto, Shinichi Asabe, Hiroyuki Miyatani, Katsuhiko Matsuura, Hirosato Mashima
    Internal medicine (Tokyo, Japan) 58 (18) 2639 - 2643 2019/09 [Refereed][Not invited]
     
    An 83-year-old man with a history of carbon ion radiotherapy for hepatocellular carcinoma nine years ago presented to a primary care hospital with a fever and abdominal pain. He underwent computed tomography, which revealed the rupture of a hepatic pseudoaneurysm close to the fiducial marker for carbon ion radiotherapy and bleeding into the bile duct. He was successfully treated with transcatheter arterial embolization. Thereafter, re-rupture occurred from a site proximal to the first rupture, and this was treated similarly. It is necessary to be alert for not only tumor recurrence but also pseudoaneurysm occurrence after carbon ion radiotherapy.
  • Infliximabによるparadoxical psoriasisとクローン病関連関節炎に対してustekinumabが有効であったクローン病の1例
    小島 柊, 松本 吏弘, 森野 美奈, 松本 圭太, 賀嶋 ひとみ, 小糸 雄大, 三浦 孝也, 高橋 裕子, 坪井 瑠美子, 石井 剛弘, 吉川 修平, 大竹 はるか, 藤原 純一, 関根 匡成, 上原 健志, 浅野 岳晴, 宮谷 博幸, 眞嶋 浩聡
    日本消化器病学会関東支部例会プログラム・抄録集 日本消化器病学会-関東支部 355回 32 - 32 2019/07 [Refereed][Not invited]
  • 関根 匡成, 松本 吏弘, 浅野 岳晴, 鷺原 規喜, 宮谷 博幸, 眞嶋 浩聡
    臨床消化器内科 (株)日本メディカルセンター 33 (7) 761  0911-601X 2018/05 [Not refereed][Not invited]
  • 大腸癌低侵襲治療の新展開 大腸ESDの難易度に関するスコアリングの構築
    松本 吏弘, 眞嶋 浩聡, 宮谷 博幸
    日本消化器病学会雑誌 (一財)日本消化器病学会 115 (臨増総会) A148  0446-6586 2018/04 [Not refereed][Not invited]
  • 当科における大腸SM癌の術前深達度診断精度
    三浦 孝也, 松本 吏弘, 森野 美奈, 松本 圭太, 賀嶋 ひとみ, 小糸 雄大, 高橋 裕子, 坪井 瑠美子, 石井 剛弘, 藤原 純一, 関根 匡成, 上原 健志, 浦吉 俊輔, 湯橋 一仁, 浅野 岳晴, 鷺原 規喜, 宮谷 博幸, 眞嶋 浩聡
    Gastroenterological Endoscopy (一社)日本消化器内視鏡学会 60 (Suppl.1) 767  0387-1207 2018/04 [Not refereed][Not invited]
  • 地方病院で始めた早期胃癌に対する内視鏡的粘膜下層剥離術師におけるラーニングカーブの検討
    藤原 純一, 松本 吏弘, 鷺原 規喜, 浅野 岳晴, 湯橋 一仁, 浦吉 俊輔, 上原 健志, 関根 匡成, 石井 剛弘, 坪井 瑠美子, 高橋 裕子, 三浦 孝也, 小糸 雄大, 賀嶋 ひとみ, 松本 圭太, 眞嶋 浩聡, 安次嶺 拓馬
    Gastroenterological Endoscopy (一社)日本消化器内視鏡学会 60 (Suppl.1) 814  0387-1207 2018/04 [Not refereed][Not invited]
  • 当院においてESDを行った大腸SM癌 診断・治療成績・予後
    石井 剛弘, 松本 吏弘, 森野 美奈, 松本 圭太, 賀嶋 ひとみ, 小糸 雄大, 高橋 裕子, 三浦 孝也, 坪井 瑠美子, 藤原 純一, 関根 匡成, 上原 健志, 浦吉 俊輔, 湯橋 一仁, 浅野 岳晴, 鷺原 規喜, 宮谷 博幸, 眞嶋 浩聡
    Gastroenterological Endoscopy (一社)日本消化器内視鏡学会 60 (Suppl.1) 849  0387-1207 2018/04 [Not refereed][Not invited]
  • 大腸癌低侵襲治療の新展開 大腸ESDの難易度に関するスコアリングの構築
    松本 吏弘, 眞嶋 浩聡, 宮谷 博幸
    日本消化器病学会雑誌 (一財)日本消化器病学会 115 (臨増総会) A148  0446-6586 2018/04 [Not refereed][Not invited]
  • The role of Gαq/Gα11 signaling in intestinal epithelial cells.
    1. Mashima H, Watanabe N, Sekine M, Matsumoto S, Asano T, Yuhashi K, Sagihara N, Urayoshi S, Uehara T, Fujiwara J, Ishii T, Tsuboi R, Miyatani H, Ohnishi H.
    Biochem Biophys Rep. 13 93 - 98 2018 [Refereed][Not invited]
  • 下部ESD-治療法の工夫・トラブルシューティング- 当院における大腸ESD
    上原 健志, 松本 吏弘, 宮谷 博幸, 眞嶋 浩聡
    Progress of Digestive Endoscopy (一社)日本消化器内視鏡学会-関東支部 92 (Suppl.) s100  1348-9844 2017/12 [Not refereed][Not invited]
  • Laser-Trelat徴候を伴う早期胃癌に対し内視鏡的粘膜下層剥離術を施行した一例
    高橋 裕子, 松本 吏弘, 田中 亨, 土橋 洋, 松本 圭太, 賀嶋 ひとみ, 小糸 雄大, 三浦 孝也, 坪井 瑠美子, 石井 剛弘, 藤原 純一, 関根 匡成, 上原 健志, 浦吉 俊輔, 山中 健一, 湯橋 一仁, 浅野 岳晴, 鷺原 規喜, 宮谷 博幸, 眞嶋 浩聡
    Progress of Digestive Endoscopy (一社)日本消化器内視鏡学会-関東支部 92 (Suppl.) s135  1348-9844 2017/12 [Not refereed][Not invited]
  • 地域病院における胃ESD導入の工夫
    藤原 純一, 松本 吏弘, 宮谷 博幸, 眞嶋 浩聡
    Progress of Digestive Endoscopy (一社)日本消化器内視鏡学会-関東支部 92 (Suppl.) s135  1348-9844 2017/12 [Not refereed][Not invited]
  • Hiroyuki Miyatani, Satohiro Matsumoto, Hirosato Mashima
    Journal of Digestive Diseases 18 (10) 591 - 597 1751-2980 2017/10 [Refereed][Not invited]
     
    OBJECTIVE: Suspected sphincter of Oddi dysfunction (SOD) is a well-known risk factor for post-endoscopic retrograde cholangiopancreatography (ERCP) pancreatitis (PEP). The indication of ERCP for suspected SOD patients was very low in Japan compared to other countries. Therefore, the risk of PEP may be different in Japanese SOD patients. The objective of this study was to evaluate the risk of PEP in suspected biliary type SOD in Japan. METHODS: From December 1996 to January 2017, 72 patients were suspected as having biliary type SOD, by questionnaire, liver function tests, hepatobiliary scintigraphy, abdominal ultrasonography, upper gastrointestinal endoscopy, endoscopic ultrasonography and magnetic resonance cholangiopancreatography. Finally, 60 patients who underwent ERCP were included in this study, and the factors associated with PEP were evaluated. RESULTS: The overall PEP rate was 23.3% (n = 14). Diagnostic ERCP alone for SOD did not increase the risk of PEP. The correlation of PEP incidence with pancreatic duct guidewire (PGW) technique and endoscopic sphincterotomy (EST) was indicated in univariate and multivariate analysis. Pancreatic stent placement was a risk in univariate analysis but not in multivariate analysis. CONCLUSIONS: PGW technique and EST for biliary type SOD were important risk factors for PEP. Pancreatic stenting was ineffective for prevention of PEP.
  • Satohiro Matsumoto, Haruna Kawamura, Takeshi Nishikawa, Noriyoshi Sagihara, Hiroyuki Miyatani, Hirosato Mashima
    Clinical and Experimental Gastroenterology 10 249 - 258 1178-7023 2017/09 [Refereed][Not invited]
     
    Background and aims: At Saitama Medical Center, for remission induction in active ulcerative colitis (UC) patients with endoscopic evidence of severe disease, we tend to preferentially use tacrolimus (TAC) over anti-tumor necrosis factor (TNF)-a agents. We conducted this study to evaluate the validity of our therapeutic strategies. Patients and methods: This retrospective study was conducted in 52 steroid-refractory active UC patients with a Clinical Activity Index (CAI) score of ≥7 who were receiving remission induction therapy with TAC or anti-TNF-α agents. The patients were divided into a TAC treatment group (TAC group, n = 29) and an anti-TNF-α agent treatment group (anti-TNF group, n = 23). The CAI, Ulcerative Colitis Endoscopic Index of Severity (UCEIS) and incidence of events (relapse, hospitalization and surgery) were retrospectively analyzed. Results: At treatment initiation, the CAI score was 12.6 in the TAC group and 11.5 in the anti-TNF group (P = 0.09), while the corresponding values of the UCEIS were 6.5 and 5.1, respectively (P = 0.0035). The clinical remission rate at 12 weeks was 55% (65% when only the subgroup that received rapid induction therapy was included in the analysis) in the TAC group and 57% in the anti-TNF group, with no significant difference. The cumulative event-free rates at 1, 6 and 12 months were 65.5%, 39.4%, and 39.4%, respectively, in the TAC group and 95.7%, 77.2% and 71.7%, respectively, in the anti-TNF group (P = 0.0037). Conclusion: Rapid induction therapy with TAC tended to be selected for active UC patients with endoscopic evidence of severe disease, and the present study supported the validity of this therapeutic approach. However, transition to the remission-maintenance phase was more favorable in the anti-TNF group.
  • 難治性潰瘍性大腸炎に対するタクロリムス長期投与の有効性と離脱のタイミング
    松本 吏弘, 川村 晴水, 森野 美奈, 松本 圭太, 賀嶋 ひとみ, 小糸 雄大, 高橋 裕子, 石井 剛弘, 若尾 聡士, 関根 匡成, 上原 健志, 西川 剛史, 浦吉 俊輔, 山中 健一, 浅野 岳晴, 鷺原 規喜, 浅部 伸一, 宮谷 博幸, 眞嶋 浩聡
    日本消化器病学会雑誌 (一財)日本消化器病学会 114 (臨増大会) A795  0446-6586 2017/09 [Not refereed][Not invited]
  • Takeshi Uehara, Satohiro Matsumoto, Mina Morino, Keita Matsumoto, Hitomi Kashima, Yuko Takahashi, Takehiro Ishii, Masanari Sekine, Shunsuke Urayoshi, Kenichi Yamanaka, Takeharu Asano, Shinichi Asabe, Noriyoshi Sagihara, Hiroyuki Miyatani, Hirosato Mashima
    GASTROINTESTINAL ENDOSCOPY 85 (5) AB260 - AB260 0016-5107 2017/05 [Refereed][Not invited]
  • Takeshi Uehara, Satohiro Matsumoto, Hiroyuki Miyatani, Hirosato Mashima
    Clinical Medicine Insights: Gastroenterology 10 1179-5522 2017 [Refereed][Not invited]
     
    Objective: We attempted to develop a scoring system for facilitating decision making regarding the performance of emergency endoscopy in patients with colonic diverticular hemorrhage. Methods : This study involved analysis of the data of 178 patients who presented with hematochezia and were diagnosed as having colonic diverticular hemorrhage by colonoscopy. The patients were divided into 2 groups depending on whether the bleeding source was identified or not at the initial endoscopy (source-identified and source-not-identified groups), and on the basis of the results obtained, we established a scoring system for predicting successful identification of the bleeding source. Res ults : The percentages of patients on oral anticoagulant therapy or with a Charlson comorbidity index of ≥6, serum C-reactive protein level of ≥1 mg/dL, or extravasation of contrast medium visualized on contrast-enhanced computed tomographic (CT) images were all significantly higher in the identified than in the nonidentified group. Multivariate analysis identified extravasation of contrast medium on contrastenhanced CT images (odds ratio [OR]: 10.6 95% confidence interval [CI]: 2.7-42.2) and use of anticoagulants (OR: 4.5 95% CI: 1.5-13.5) as independent predictors of successful identification of the bleeding source at the initial endoscopy in patients with colonic diverticular hemorrhage. On the basis of these results, we established a scoring system, which showed a sensitivity of 80% and specificity of 81% for successful identification of the bleeding source at the initial endoscopy. Conclusions: Herein, we propose a scoring system as a useful tool for determining whether emergency endoscopy is indicated in individual patients with suspected colonic diverticular hemorrhage.
  • The efficacy of endoscopic submucosal dissection for colorectal tumors extending to the dentate line.
    Matsumoto S, Mashima H.
    Int J Colorectal Dis. 32 831 - 837 2017 [Refereed][Not invited]
  • Haruka Otake, Satohiro Matsumoto, Hirosato Mashima
    MEDICINE 96 (16) e6635  0025-7974 2017 [Refereed][Not invited]
     
    Although biologics are important inflammatory bowel disease therapies, loss of response (LOR) remains problematic. We evaluated LOR to biologics in our Crohn disease (CD) patients receiving biologics. Of 137 biologic-treated CD patients, 68 continuously receiving the same biologic type for at least 1 year were divided into 2 groups: infliximab (IFX) (n= 39) and adalimumab (ADA) (n= 29). Clinical courses were compared at biologic introduction and at 1 year. Both groups were retrospectively analyzed for LOR at and beyond 1 year after biologic introduction (study endpoint). Patients were then divided into LOR and non-LOR groups to identify factors predicting LOR. At 1 year after biologic introduction, decreases in CD activity index were 94 +/- 105 in the IFX and 102 +/- 89 in the ADA group, not significantly different. Blood test data did not differ between these groups. LOR occurred in 14 IFX and 5 ADA group patients. Event-free rates at 5 years after biologic introduction were 62% in the IFX and 61% in the ADA group. Patients achieving clinical remission 1 year after biologic introduction accounted for 69% of the IFX and 90% of the ADA group, while respective rates of secondary LOR at 5 years were 32% and 26%. C-reactive protein (CRP) at biologic introduction (odds ratio [OR], 1.5; 95% confidence interval [CI], 1.04-2.06; P=. 02) and age at CD onset (OR, 1.1; 95% CI, 1.01-1.20; P=. 03) predicted LOR. As to IFX and ADA efficacies after 1 year of administration, there were no significant differences in event-free rates for the 5 years after biologic introduction or the secondary LOR rate. CRP at biologic introduction and age at CD onset predicted LOR.
  • Risk factors of post-ERCP pancreatitis in biliary type Sphincter of Oddi dysfunction in Japanese patients.
    Miyatani H, Matsumoto S, Mashima H.
    J Dig Dis. 18 591 - 598 2017 [Refereed][Not invited]
  • Rapid induction therapy with oral tacrolimus in elderly patients with refractory ulcerative colitis may easily lead to elevated tacrolimus concentrations in the blood: Report of five Cases.
    Kawamura H, Matsumoto S, Nakamura N, Miyatani H, Mashima H.
    Am J Case Rep. 18 405 - 409 2017 [Refereed][Not invited]
  • A case with serrated polyposis syndrome controlled by multiple applications of endoscopic mucosal resection and endoscopic submucosal dissection.
    Suzuki D, Matsumoto S, Mashima H.
    Am J Case Rep. 18 304 - 307 2017 [Refereed][Not invited]
  • 当科における潰瘍性大腸炎に対するタクロリムスと生物学的製剤の短期・長期治療成績
    松本 吏弘, 眞嶋 浩聡, 川村 晴水, 西川 剛史, 浦吉 俊輔, 山中 健一, 鷺原 規喜, 宮谷 博幸
    日本消化器病学会雑誌 (一財)日本消化器病学会 113 (臨増大会) A768  0446-6586 2016/09 [Not refereed][Not invited]
  • 上原 健志, 松本 吏弘, 小糸 雄大, 賀嶋 ひとみ, 石井 剛弘, 田村 洋行, 大竹 はるか, 新藤 雄司, 西川 剛史, 川村 晴水, 大滝 雄造, 浦吉 俊輔, 山中 健一, 牛丸 信也, 浅野 岳晴, 岩城 孝明, 鷺原 規喜, 浅部 伸一, 宮谷 博幸, 眞嶋 浩聡
    Gastroenterological Endoscopy (一社)日本消化器内視鏡学会 58 (Suppl.1) 689  0387-1207 2016/04 [Not refereed][Not invited]
  • Koutaro Kunitomo, Akihide Ohkuchi, Satohiro Matsumoto, Masafumi Wada, Ryuichi Himeno, Tatsuyoshi Sakamoto
    JOURNAL OF OBSTETRICS AND GYNAECOLOGY RESEARCH 42 (3) 353 - 357 1341-8076 2016/03 [Refereed][Not invited]
     
    There have been few reports regarding the improvement of hyperammonemic hepatic encephalopathy after the extirpation of a large uterine leiomyoma. We present a case of a 53-year-old postmenopausal woman who experienced a clouding of consciousness. She had been suffering from mild hepatitis and a large uterine leiomyoma. On admission, she had experienced constipation for seven days and exhibited a high serum ammonia level (251 g/dL). She was diagnosed with liver cirrhosis as a result of autoimmune hepatitis, combined with Sjogren's syndrome. A total hysterectomy was performed 29 days after admission. Severe diarrhea lasted for three days after surgery. By the sixth postoperative day, the patient's consciousness level had normalized and her serum ammonia level had fallen to 47 g/dL. Although the true mechanism of hyperammonemia in this case is unclear, we speculate that organic constipation following chronic obstruction of the colon might have played a role in the development of the condition.
  • 鷺原 規喜, 井上 依里, 矢部 寛樹, 賀嶋 ひとみ, 小糸 雄大, 石井 剛弘, 坪井 瑠美子, 田村 洋行, 上原 健志, 大竹 はるか, 池田 正俊, 新藤 雄司, 川村 晴水, 西川 剛司, 大滝 雄造, 浦吉 俊輔, 山中 健一, 牛丸 信也, 浅野 岳晴, 岩城 孝明, 松本 吏弘, 浅部 伸一, 宮谷 博幸, 田中 裕一, 野首 光弘, 眞嶋 浩聡
    自治医科大学紀要 (学)自治医科大学 38 59  1881-252X 2016/03 [Not refereed][Not invited]
     
    31歳女性。大動脈炎症候群の治療中に、血便を認め当センターに入院した。下部消化管内視鏡検査にて、終末回腸に縦走潰瘍を認め、小腸型クローン病と診断した。寛解導入療法として、栄養療法とメサラジン製剤の内服に加え、生物学的製剤アダリムマブを投与した。寛解を得た後、プレドニゾロン・メトトレキセートの減量を行ったが、両疾患とも再燃・悪化なく経過している。両疾患の合併は稀であり、本邦からの報告例が19例、国外からの報告例を加えると55例に過ぎない。発症の順序に規則性は認めない。今回貴重な症例を経験したので、文献的考察を加え、報告する。(著者抄録)
  • 西川 剛史, 松本 吏弘, 眞嶋 浩聡, 小糸 雄大, 賀嶋 ひとみ, 石井 剛弘, 坪井 瑠美子, 大竹 はるか, 新藤 雄司, 上原 健志, 川村 晴水, 大滝 雄造, 浦吉 俊輔, 山中 健一, 牛丸 信也, 浅野 岳晴, 岩城 孝明, 鷺原 規喜, 浅部 伸一, 宮谷 博幸
    日本消化器病学会雑誌 (一財)日本消化器病学会 113 (臨増総会) A339  0446-6586 2016/03 [Not refereed][Not invited]
  • Satohiro Matsumoto, Hirosato Mashima
    Case Reports in Gastroenterology 10 (1) 157 - 160 1662-0631 2016 [Refereed][Not invited]
     
    Diversion colitis is a benign inflammatory process that occurs in any part of the large bowel excluded from the fecal stream by a diverting colostomy. While most of the patients with diversion colitis usually are asymptomatic, a minority has abdominal pain and rectal discharge of blood or mucus. A 65-year-old Japanese man was diagnosed as having diversion colitis with ulcerative colitis at 4 months after subtotal colectomy. Corticosteroid and mesalazine enemas were started nonsynchronously. A proctoscopy after 2 months showed no response. Prednisolone injections were started at 1.0 mg/kg daily, but the mucosal inflammation still failed to improve. A combined mesalazine 1 g plus prednisolone sodium phosphate 20 mg enema was started once daily. The rectal bleeding and endoscopic findings improved. Finally proctectomy and ileal pouch-anal anastomosis were successfully performed. A combined mesalazine plus corticosteroid enema may be effective in patients with diversion colitis associated with ulcerative colitis.
  • Rumiko Kobayashi, Satohiro Matsumoto, Yukio Yoshida
    Case Reports in Gastroenterology 10 (2) 392 - 398 1662-0631 2016 [Refereed][Not invited]
     
    In recent years, cases of elderly-onset ulcerative colitis (UC) have been increasing in number and are currently reported to account for 10-15% of all cases of UC. Although the treatment of UC is essentially similar between older and younger patients, evidence of the therapeutic efficacy of tacrolimus in elderly-onset UC patients is still limited. Herein, we report our attempt to induce remission using tacrolimus in three patients with elderly-onset UC. A 75-year-old Japanese woman, a 71-year-old Japanese man and a 76-year-old Japanese woman with severe elderly-onset UC of the pancolitis type were treated with tacrolimus. Although all three patients showed response to the drug, the eventual outcome was poor in the first patient, who developed toxic megacolon, underwent surgery, and suffered from recurrent infections and hemorrhage after the surgery. However, clinical remission was successfully achieved in the second and third patient. Tacrolimus shows some indication of effectiveness in the treatment of elderly-onset UC. However, in elderly-onset UC patients, it is necessary to keep in mind the higher risk of adverse effects of medical therapy and postoperative complications because of the high comorbidity rates. Moreover, in situations where surgery needs to be considered, it is important to ensure appropriate timing of the surgery.
  • Risk factors for postoperative bleeding after gastric endoscopic submucosal dissection in patients under antithrombotics.
    Shindo Y, Matsumoto S, Miyatani H, Yoshida Y, Mashima H.
    World J Gastroenterol. 8 349 - 356 2016 [Refereed][Not invited]
  • Future directions of duodenal endoscopic submucosal dissection.
    Matsumoto S, Miyatani H, Yoshida Y.
    World J Gastroenterol Endoscopy 4 389 - 395 2015 [Refereed][Not invited]
  • Efficacy of a pH-dependent controlled-release mesalazine based on clinical and endoscopic assessment for ulcerative colitis: a retrospective cohort study.
    Matsumoto S, Yoshida Y.
    Clinical and Experimental Gastroenterology 8 225 - 230 2015 [Refereed][Not invited]
  • Infliximab-induced thrombocytopenia in a patient with ulcerative colitis.
    Matsumoto S, Mashima H
    Int J Colorectal Dis 31 921 - 922 2015 [Refereed][Not invited]
  • Urayoshi Shunsuke, Matsumoto Satohiro, Miyatani Hiroyuki, Yoshida Yukio
    Progress of Digestive Endoscopy(1972) Japan Gastroenterological Endoscopy Society Kanto Chapter 86 (1) 178 - 179 1348-9844 2015 [Not refereed][Not invited]
     
    A one-week eradication therapy of <i>Helicobacter pylori</i> using metronidazole, clarithromycin, and omeprazole is generally considered a well-tolerated therapy with minor side effects. We report a 66-year-old male patient who developed diarrhea few days after the treatment, and <i>Clostridium difficile</i> toxin was detected in his stool. Although this is a rare complication, it can sometimes o
  • Satohiro Matsumoto, Shunsuke Urayoshi, Yukio Yoshida
    BMC Research Notes 7 (1) 678  1756-0500 2014/09 [Refereed][Not invited]
     
    Background: Familial Mediterranean fever is a hereditary autoinflammatory disease, mainly characterized by periodic fever and serositis. The level of awareness about familial Mediterranean fever is far from sufficient, and it is assumed that there may be many patients with this disease who are under observation without an accurate diagnosis. Case presentation: A 30-year-old Japanese man presented to us with a few years' history of recurrent episodes of fever, abdominal pain and diarrhea. He often visited a hospital when the attacks occurred however, acute enteritis was diagnosed each time, and the symptoms resolved spontaneously within a few days. When he noticed a shortening of the interval between the attacks, he visited the hospital again. Upper endoscopy and colonoscopy performed at this hospital revealed no significant abnormal findings. He was then referred to our hospital under the suspicion of a small intestinal disease. Abdominal computed tomography revealed wall thickening and increased density of the mesenteric adipose tissue in the jejunum, which led us to suspect Crohn's disease. Oral double-balloon enteroscopy was performed because this revealed only mild mucosal edema in the jejunum, Crohn's disease was considered to be highly improbable. Based on the patient's clinical course, we suspected familial Mediterranean fever. As the Livneh criteria for familial Mediterranean fever were satisfied, the patient was started on oral colchicine for the purpose of diagnostic treatment. A definitive diagnosis of familial Mediterranean fever was then made based on the detection of a mutation of the Mediterranean fever gene. A marked reduction in the frequency of attacks was observed in response to colchicine treatment. Conclusions: Although Crohn's disease may be considered first in the differential diagnosis of young patients presenting with periodic fever, abdominal pain and diarrhea, the possibility of familial Mediterranean fever should also be borne in mind.
  • Satohiro Matsumoto, Yukio Yoshida
    WORLD JOURNAL OF GASTROENTEROLOGY 20 (26) 8624 - 8630 1007-9327 2014/07 [Refereed][Not invited]
     
    AIM: To determine an appropriate compartmentalization of endoscopic submucosal dissection (ESD) or endoscopic mucosal resection (EMR) for duodenal tumors. METHODS: Forty-six duodenal lesions (excluding papillary lesions) from 44 patients with duodenal tumors treated endoscopically between 2005 and 2013 were divided into the ESD and EMR groups for retrospective comparison and analysis. RESULTS: The mean age was 65 +/- 9 years (35-79 years). There were 24 lesions from men and 22 from women. The lesions consisted of 6 early cancers, 31 adenomas and 9 neuroendocrine tumors. Lesion location was the duodenal bulb in 15 cases and the descending part of the duodenum in 31 cases. The most common macroscopic morphology was elevated type in 21 cases (45.6%). Mean tumor diameter was 11.9 +/- 9.7 mm (3-60 mm). Treatment procedure was ESD (15 cases) vs EMR (31 cases). The examined parameters in the ESD vs EMR groups were as follows: mean tumor diameter, 12.9 +/- 14.3 mm (3-60 mm) vs 11.4 +/- 6.7 mm (4-25 mm); en bloc resection rate, 86.7% vs 83.9%; complete resection rate, 86.7% vs 74.2%; procedure time, 86.5 +/- 63.1 min (15-217 min) vs 13.2 +/- 17.0 min (2-89 min) (P < 0.0001); intraprocedural perforation, 3 cases vs none (P = 0.0300); delayed perforation, none in either group; postprocedural bleeding, 1 case vs none; mean postoperative length of hospitalization, 8.2 +/- 2.9 d (5-16 d) vs 6.1 +/- 2.0 d (2-12 d) (P = 0.0067); recurrence, none vs 1 case (occurring at 7 mo postoperatively). CONCLUSION: ESD was associated with a longer procedure time and a higher incidence of intraprocedural perforation; EMR was associated with a lower rate of complete resection. (C) 2014 Baishideng Publishing Group Inc. All rights reserved.
  • Rumiko Kobayashi, Satohiro Matsumoto, Yukio Yoshida
    WORLD JOURNAL OF GASTROENTEROLOGY 20 (23) 7514 - 7517 1007-9327 2014/06 [Refereed][Not invited]
     
    A 25-year-old man was admitted with the chief complaints of right flank pain, watery diarrhea, and fever. Blood tests revealed high levels of inflammatory markers, and infectious enteritis was diagnosed. A stool culture obtained on admission revealed no growth of any significant pathogens. Conservative therapy was undertaken with fasting and fluid replacement. On day 2 of admission, the fever resolved, the frequency of defecation reduced, the right flank pain began to subside, and the white blood cell count started to decrease. On hospital day 4, the frequency of diarrhea decreased to approximately 5 times per day, and the right flank pain resolved. However, the patient developed epigastric pain and increased blood levels of the pancreatic enzymes. Abdominal computed tomography revealed mild pancreatic enlargement. Acute pancreatitis was diagnosed, and conservative therapy with fasting and fluid replacement was continued. A day later, the blood levels of the pancreatic enzymes peaked out. On hospital day 7, the patient passed stools with fresh blood, and Campylobacter jejuni/coli was detected by culture. Lower gastrointestinal endoscopy performed on hospital day 8 revealed diffuse aphthae extending from the terminal ileum to the entire colon. Based on the findings, pancreatitis associated with Campylobacter enteritis was diagnosed. In the present case, a possible mechanism of onset of pancreatitis was invasion of the pancreatic duct by Campylobacter and the host immune responses to Campylobacter. (C) 2014 Baishideng Publishing Group Inc. All rights reserved.
  • Satohiro Matsumoto, Yukio Yoshida
    EUROPEAN JOURNAL OF GASTROENTEROLOGY & HEPATOLOGY 26 (3) 282 - 287 0954-691X 2014/03 [Refereed][Not invited]
     
    ObjectiveWe investigated factors that may affect hospitalization and surgery in patients presenting with aggravation of ulcerative colitis (UC).Materials and methodsThis study included 222 UC patients who had visited our hospital regularly since 2000 (127 men, 95 women; mean age at onset, 3416 years). We divided the patients into groups according to whether or not they were hospitalized for aggravation of UC (hospitalized group, n=75; nonhospitalized group, n=147), compared the clinical features and clinical courses between the two groups, and also analyzed the cumulative rates of surgery. Then, only the 75 patients of the hospitalized group were divided into two groups for a subanalysis (colectomy group, n=25; noncolectomy group, n=50).ResultsIn the hospitalized group, the rates of use of steroids and thiopurine immunomodulators were significantly higher, and the rates of concurrent cytomegalovirus (CMV) infection and surgery for UC aggravation were also significantly higher. Multivariate analysis identified CMV infection [odds ratio (OR), 8.2; 95% confidence interval (CI), 1.91-35.33; P=0.0047] and steroid use (OR, 4.4; 95% CI, 1.30-14.93; P=0.0170) as risk factors for hospitalization because of UC aggravation. Moreover, the cumulative rate of surgery was significantly higher in the hospitalized group (P<0.0001). Multivariate analysis as part of the subanalysis identified the use of thiopurine immunomodulators as a factor for avoidance of surgery (OR, 0.2; 95% CI, 0.08-0.67; P=0.0072).ConclusionConcurrent CMV infection was associated with an eight-fold increase in the risk of hospitalization for UC aggravation. In contrast, maintenance therapy with thiopurine immunomodulators reduced the risk of surgery by 80%.
  • Satohiro Matsumoto, Yukio Yoshida
    Indian Journal of Gastroenterology 33 (1) 46 - 49 0254-8860 2014 [Refereed][Not invited]
     
    Although endoscopic screening has become more common in recent years, its efficacy in reducing the mortality from gastric cancer has not yet been demonstrated. We carried out a case-control study to evaluate the efficacy of endoscopic screening in Kamigoto town, Kamigoto Island. The case group consisted of 13 patients who died of gastric cancer between 2000 and 2008, and ten controls per patient, ie. a total of 130 controls, were extracted as the control group. To clarify the relationship between participation in endoscopic screening and gastric cancer mortality, the odds ratio of death from gastric cancer in participants vs. nonparticipants of screening was calculated. The odds ratio of death from gastric cancer in participants of endoscopic screening vs. nonparticipants was 0.206 (95 % CI, 0.044-0.965 p = 0.0449). Participation in endoscopic screening within the previous 5 years decreased the risk of death from gastric cancer by 79 %. Implementation of endoscopic screening was associated with a significant reduction in mortality from gastric cancer in the small island town. © 2013 Indian Society of Gastroenterology.
  • Satohiro Matsumoto, Shizukiyo Ishikawa, Yukio Yoshida
    AUSTRALIAN JOURNAL OF RURAL HEALTH 21 (6) 319 - 324 1038-5282 2013/12 [Refereed][Not invited]
     
    ObjectiveTo evaluate the efficacy of endoscopic and radiographic screening for gastric cancer. DesignA retrospective cohort study. SettingCommunity in an isolated island. ParticipantsThe study involved 186 patients (131 men, 55 women) diagnosed with gastric cancer between 2000 and 2005. InterventionsEndoscopic and radiographic screening. Main outcome measurementsThe odds ratio of death from gastric cancer in participants versus non-participants of screening, the cumulative survival rate of the gastric cancer patients. ResultsThe odds ratio of death from gastric cancer in the participants versus non-participants of screening was 0.091 (95% confidence interval (CI) 0.027-0.308; P<0.0001). The cumulative survival rate of the gastric cancer patients in the screening group was higher than that in the non-screening group (P<0.0001). In the endoscopic screening district, the odds ratio of death from gastric cancer among the participants versus non-participants of endoscopic screening was 0.117 (95% CI 0.013-1.056; P=0.0525), while in the radiographic screening district, it was 0.086 (95% CI 0.020-0.376; P<0.0001). The cumulative survival rates were higher in both the screening groups as compared with the non-screening group (endoscopy, P=0.0302; radiography, P=0.0012). ConclusionThe results suggest that both radiographic and endoscopic screening may prevent gastric cancer deaths.
  • Satohiro Matsumoto, Hiroyuki Miyatani, Yukio Yoshida
    DIGESTIVE DISEASES AND SCIENCES 58 (5) 1306 - 1312 0163-2116 2013/05 [Refereed][Not invited]
     
    We examined the pathologies, treatment characteristics, and clinical course of elderly ulcerative colitis (UC) patients. Among 222 UC patients (127 men, 95 women; average age, 34 +/- A 16 years), we selected 109 with UC diagnosed between 20 and 39 years of age (young adult group) and 23 diagnosed at a parts per thousand yen60 years of age (elderly group). Moreover, 12 patients diagnosed between 60 and 64 years of age (late-onset group) and 6 patients aged a parts per thousand yen60 years diagnosed under 50 years old (long-standing group) were also extracted for sub-analysis. The clinical characteristics and course were compared among the groups. The average age at onset was 29 +/- A 6 years in the young adult group and 66 +/- A 5 years in the elderly group. The frequency of immunomodulator or steroid use did not differ between the two groups. The comorbidity rate was 14.7 % in the young adult group and 69.6 % in the elderly group (P < .0001). Seven patients (58.3 %) in the late-onset UC group and none of the patients in the long-standing UC group were on steroid treatment. None of the patients in the long-standing UC group required hospitalization/surgery for UC exacerbation, while 3 (25.0 %) and 2 patients (16.7 %) in the late-onset group required hospitalization and surgery, respectively. The comorbidity rate was significantly higher in the elderly group. Treatments did not differ significantly between the young adult and elderly groups. Therefore, it appears that the inflammation tends to subside with age in elderly patients with long-standing UC.
  • S. Matsumoto, H. Miyatani, Y. Yoshida
    ENDOSCOPY 45 (2) 136 - 137 0013-726X 2013/02 [Refereed][Not invited]
     
    The indications for endoscopic submucosal dissection (ESD) for duodenal tumors have not yet been established. We reviewed our experience of ESD performed for duodenal tumors. We analyzed the data of a total of 13 patients with 14 duodenal lesions (excluding papillary lesions) comprising 2 early cancers, 5 adenomas, and 7 neuroendocrine tumors, who were treated by ESD between 2005 and 2011. The mean tumor diameter was 12.7 +/- 14.8 mm. En bloc resection was achieved in 85.7% of the cases. The procedure time was 89.1 +/- 64.6 minutes. Intraoperative perforation occurred in three cases. The mean length of postoperative hospitalization was 8.4 +/- 2.4 days. Because ESD for duodenal lesions was associated with a higher incidence of perforation than ESD for lesions in other locations (stomach, esophagus, and colon) reported previously, its use for duodenal lesions should be considered with caution.
  • Yuji Shindo, Hiroyuki Miyatani, Takeshi Uehara, Takashi Ikeya, Kenichi Yamanaka, Masatoshi Ikeda, Kouichi Tokai, Shinya Ushimaru, Satohiro Matsumoto, Takeharu Asano, Toru Takamatsu, Masanori Fukunishi, Takaaki Iwaki, Yoshinori Sagihara, Shinichi Asabe, Yukio Yoshida
    Journal of Japanese Society of Gastroenterology 109 (7) 1243 - 1249 0446-6586 2012/07 [Refereed][Not invited]
     
    A 78-year-old man with hepatocellular carcinoma treated by chemoembolization and percutaneous ethanol injection was admitted to our hospital because of acute abdomen. The CT scan showed biliary fistula caused by hepatocellular carcinoma protruding from S3. Endoscopic retrograde cholangiopancreatography showed disruption of an intrahepatic duct and the main pancreatic duct, and contrast agent leaked into the peritoneal cavity from each duct Omental panniculitis with biliary fistula and pancreatic fistula was diagnosed. The symptoms improved by endoscopic nasobiliary drainage and endoscopic pancreatic stenting. On the 13th day after admission, we added endoscopic nasopancreatic drainage because his abdominal pain had been exacerbated by pancreatic juice leakage. Omental panniculitis by hepatocellular carcinoma complicated by biliary fistula and pancreatic fistula is extremely rare. Endoscopic transpapillary pancreaticobiliary drainage was effective for omental panniculitis in this case.
  • Satohiro Matsumoto, Hiroyuki Miyatani, Yukio Yoshida, Mitsuhiro Nokubi
    GASTROINTESTINAL ENDOSCOPY 74 (5) 1152 - 1156 0016-5107 2011/11 [Refereed][Not invited]
  • Takuhiro Ugajin, Hiroyuki Miyatani, Satohiro Matsumoto, Tohru Takamatsu, Masanori Fukunishi, Yukio Yoshida, Yoh Dobashi
    DIGESTIVE ENDOSCOPY 23 (4) 328 - 328 0915-5635 2011/10 [Refereed][Not invited]
  • TAKAMATSU Toru, TOUKAI Kouichi, USHIMARU Shinya, MATSUMOTO Satohiro, IWAKI Takaaki, FUKUNISHI Masanori, SAGIHARA Noriyoshi, MIYATANI Hiroyuki, YOSHIDA Yukio, YAMADA Shigeki
    Gastroenterological Endoscopy 一般社団法人 日本消化器内視鏡学会 53 (9) 3023 - 3027 0387-1207 2011/09 
    Esophageal submucosal tumors (SMTs) are almost all benign in nature, and a malignant SMT is rare. Endoscopic ultrasound (EUS) can give useful information about the differentiation between benign and malignant SMTs, but it is sometimes difficult and occasionally impossible. Treatment policies for SMTs differ depending on the histological type, therefore diagnosis of an SMT requires histological and immunohistochemical confirmation. EUS-guided fine needle aspiration biopsy (EUS-FNAB) is an effective technique to obtain tissue samples of an SMT with minimal risk. We report on a case of an esophageal SMT diagnosed from a direct-observation biopsy by mucosal cutting. We think this method may be tried in convex type EUS-free facilities and, if not enough tissue could be collected with EUS-FNAB.
  • Satohiro Matsumoto, Hiroyuki Miyatani, Yukio Yoshida, Mitsuhiro Nokub
    GASTROINTESTINAL ENDOSCOPY 73 (6) 1309 - 1312 0016-5107 2011/06 [Refereed][Not invited]
  • MATSUMOTO Satohiro
    Nihon Shoukaki Gan Kenshin Gakkai zasshi 一般社団法人 日本消化器がん検診学会 48 (4) 436 - 441 1880-7666 2010/07 
    [Objective] This study was conducted to explore the effectiveness of gastric endoscopic screening in reducing the mortality of gastric cancer.
    [Subjects and Methods] Patients who underwent health screenings were divided into three gender- and age-matched groups: an X-ray examination group (n=1,425), an endoscopic examination group (n=2,264), and a non-examination group (n=6,284). They were followed up until December 2008. The cumulative survival rate was calculated for each of the three groups, whereby the hazard ratio for the mortality in each examination group was determined.
    [Results] Of the 40 patients having developed gastric cancer (X-ray examination group, 18 patients; endoscopic examination group, 12 patients; and non-examination group, 10 patients), 1 patient in the X-ray examination group, 1 patient in the endoscopic examination group and 8 patients in the non-examination group died of gastric cancer. The cumulative survival rate did not significantly differ between the X-ray examination group and the endoscopic examination group, and was significantly lower in the non-examination group compared to that in the other two groups (p=0.0073). The non-examination group was found to be associated with an 8-fold greater risk of death from gastric cancer than the endoscopic examination group (p=0.0499).
    [Conclusion] Endoscopic health screening was noted to be effective in reducing the mortality of gastric cancer, suggesting the possibility that endoscopic health screening is not inferior to screening by X-ray examination in this respect.
  • IWAKI Takaaki, MIYATANI Hiroyuki, IKEYA Takashi, YAMANAKA Kenichi, IKEDA Masatoshi, USHIMARU Shinya, MATSUMOTO Satohiro, TAKAMATSU Toru, FUKUNISHI Masanori, SAGIHARA Noriyoshi, YOSHIDA Yukio
    Suizo Japan Pancreas Society 25 (2) 132 - 137 0913-0071 2010/04 
    This is the first report of impacted papilla minor stone in pancreas divisum successfully treated with endoscopic minor papillotomy.
    A 50-year-old male with a complaint of sudden upper abdominal pain was seen at a local hospital, and he had had no history of pancreatitis. He was referred to our hospital and was diagnosed as having pancreas divisum and dorsal pancreatitis with impacted papilla minor stone based on multidetector-row computed tomography. Endoscopic retrograde pancreatography via the accessory papilla showed diffuse dilatation of the isolated dorsal pancreatic duct and filling defect. He was treated with endoscopic minor papillotomy and endoscopic nasopancreatic drainage and was discharged on the 36th day of his hospital stay. There were no further episodes of abdominal pain or pancreatitis after a follow-up period of 16 months.
    This case report suggests that endoscopic minor papillotomy is one of the effective treatments for dorsal pancreatitis resulting from an impacted papilla minor stone in pancreas divisum.
  • Yamanaka Kenichi, Miyatani Hiroyuki, Uehara Takeshi, Shindou Yuuji, Urayoshi Syunsuke, Higuchi Yuusuke, Ikeda Masatoshi, Toukai Koichi, Ushimaru Shinya, Matsumoto Satohiro, Takamatsu Toru, Iwaki Takaaki, Fukunishi Masanori, Sagihara Noriyoshi, Yoshida Yukio
    Progress of Digestive Endoscopy(1972) Japan Gastroenterological Endoscopy Society Kanto Chapter 76 (2) 124 - 125 1348-9844 2010 
    症例は52歳女性。45歳時に膵管非癒合による急性膵炎の既往あり。心窩部痛にて当院救急搬送され,急性膵炎と診断された。軽快後,膵管非癒合の精査目的にERPを施行した。経副乳頭的に行った圧測定で,膵管内圧上昇と副乳頭部で括約筋様収縮波を認めた。副乳頭切開を施行し,その後膵炎の再発はない。経副乳頭的内圧測定は膵管非癒合による再発性膵炎に対して,副乳頭切開を行う際の指標として有用である可能性が考えられた。
  • Matsumoto Satohiro, Ikeda Masatoshi, Ushimaru Shinya, Takamatsu Toru, Miyatani Hiroyuki, Yoshida Yukio
    Progress of Digestive Endoscopy(1972) Japan Gastroenterological Endoscopy Society Kanto Chapter 76 (2) 84 - 85 1348-9844 2010 
    症例は78歳,女性。主訴は貧血,食後腹痛。NSAIDs小腸潰瘍を疑われ当科に転院。カプセル内視鏡にて空腸に狭窄病変を指摘され,経口的ダブルバルーン小腸内視鏡にて空腸に2箇所の膜様狭窄を認め,径8mmのバルーン拡張を施行。NSAIDs関連性小腸潰瘍による瘢痕狭窄と診断した。食上げ中に腹痛の再燃を認め,2度目のDB小腸内視鏡にて径13mmまでの拡張を行った。その後症状の再燃みられず軽快退院となった。
  • Higuchi Yusuke, Matsumoto Satohiro, Miyatani Hiroyuki, Yamanaka Kenichi, Ikeda Masatoshi, Ushimaru Shinya, Takamatsu Toru, Fukunishi Masanori, Iwaki Takaaki, Sagihara Noriyoshi, Yoshida Yukio, Konishi Fumio
    Progress of Digestive Endoscopy(1972) Japan Gastroenterological Endoscopy Society Kanto Chapter 76 (2) 116 - 117 1348-9844 2010 
    症例は35歳男性。クローン病にてS状結腸に狭窄あり,狭窄部切除術後infliximabを投与開始した。Infliximab投与後,腸管狭窄が出現したためバルーン拡張術を試みたが,狭窄長が長く屈曲していたため穿孔の危険性が高く,手術に至った。Infliximab投与後に腸管狭窄が出現した症例を経験したので報告する。
  • Kenichi Yamanaka, Hiroyuki Miyatani, Yoshiyuki Nakashima, Takashi Ikeya, Masatoshi Ikeda, Shinya Ushimaru, Satohiro Matsumoto, Hideaki Honda, Toru Takamatsu, Takaaki Iwaki, Masanori Fukunishi, Noriyoshi Sagihara, Yukio Yoshida, Hiroshi Noda, Nobuyuki Tooyama, You Dobashi
    Acta Hepatologica Japonica 51 (7) 387 - 393 0451-4203 2010 [Refereed][Not invited]
     
    The patient was a 78-year-old male who had been found to have multiple hepatic cysts and renal cysts at 68 years of age. Because multiple hepatic cysts and a solid mass in some of the cysts were observed on a follow-up CT scan in December 2007, he was referred to our department for a thorough examination and treatment in March 2008. Abdominal ultrasonography showed multiple cysts in both lobes of the liver, and papillary protruding masses were observed in a cyst in S3 of the left lobe and a cyst in S7 of the right lobe. Abdominal CT showed a soft-tissue-density mass associated with weak contrast enhancement in the cyst at both sites. An FDG-PET study showed no abnormal accumulation in the liver. It was impossible to identify any communication between either of the two cysts and the bile duct by ERCP or MRCP. Cystic tumors were strongly suspected, and partial hepatectomy was performed. Histopathological examination revealed that the solid portion observed in part of a multilocular cystoma was vascular connective tissue that had the thickened cyst wall, while the portion that was thought to be a cystic protruding lesion was a thrombotic mass caused by intracystic hemorrhage, part of which had become organized, and there was no evidence of adenoma or cancer. Since cases of simultaneous multiple hepatic cysts with intracystic hemorrhage and a tendency to enlarge are extremely rare, we report here the case together with a brief discussion based on the literature. © 2010 The Japan Society of Hepatology.
  • Takamatsu Toru, Yamanaka Kenichi, Ushimaru Shinya, Matsumoto Fumihiro, Iwaki Takaaki, Ikeda Masatoshi, Sagihara Noriyoshi, Miyatani Hiroyuki, Yoshida Yukio
    Progress of Digestive Endoscopy(1972) Japan Gastroenterological Endoscopy Society Kanto Chapter 75 (2) 102 - 103 1348-9844 2009 
    症例は67歳男性。上行結腸に60mmのIp様のSMTを認め,粘膜下脂肪腫と診断した。2チャンネルスコープを用い,留置スネアで基部を絞扼し,33mmスネアにてpolypectomyを実施した。短時間に一括切除可能であったが,術後に軽度のair leakを認めた。脂肪腫の内視鏡治療に際しては,病変の形状により完全切除にこだわらずリスクを考慮した治療法を選択すべきである。
  • Ikeya Takashi, Ushimaru Shinya, Ikeda Masatoshi, Honda Hideaki, Matsumoto Satohiro, Takamatsu Tohru, Miyatani Hiroyuki, Yoshida Yukio
    Progress of Digestive Endoscopy(1972) Japan Gastroenterological Endoscopy Society Kanto Chapter 74 (2) 120 - 121 1348-9844 2009 
    自己免疫性膵炎の治療中に肝門部胆管狭窄を認め,胆管癌との鑑別に苦慮した自己免疫性胆管炎の1例を経験した。症例は65歳男性,自己免疫性膵炎に対しステロイドを漸減中に胆道系酵素が上昇し,腹部超音波検査・腹部CTで右肝内胆管の拡張及び肝門部に腫瘤様陰影を認めた。胆管ブラシ細胞診,胆汁細胞診では悪性所見は見られなかった。ステロイドを増量し2週間後には肝門部の胆管狭窄は改善し,その後腫瘤影も消失した。
  • Miyatani Hiroyuki, Yoshida Yukio, Ikeya Takashi, Ushimaru Shinya, Ikeda Masatoshi, Honda Hideaki, Matsumoto Satohiro, Takamatsu Toru
    Progress of Digestive Endoscopy(1972) Japan Gastroenterological Endoscopy Society Kanto Chapter 75 (2) 54 - 55 1348-9844 2009 
    症例は71歳,パーキンソン病で治療中の女性。朝食後,内服薬4TをPTP包装のまま誤飲,咽頭痛が持続するため,救急車で来院した。異物摘出目的に緊急内視鏡施行,食道内に2個,胃内に2個のPTPおよびLm,F2,Cb,Rc sign陽性の食道静脈瘤を認めた。EVL用オーバーチューブ挿入後,スコープに先端フードを装着し,把持鉗子で把持し,慎重な操作の下,4個のPTPを摘出した。食道胃接合部付近では十分に送気することにより噴門を開大し,出血させることなく摘出可能であった。
  • Miyatani Hiroyuki, Yoshida Yukio, Ikeya Takashi, Ushimaru Shinya, Ikeda Masatoshi, Honda Hideaki, Matsumoto Satohiro, Takamatsu Toru, Yamada Shigeki
    Progress of Digestive Endoscopy(1972) Japan Gastroenterological Endoscopy Society Kanto Chapter 74 (2) 114 - 115 1348-9844 2009 
    症例は23歳女性。腹腔内腫瘍の精査目的に当センター紹介となる。右上腹部を中心に10cm大の弾性硬・表面平滑な腫瘤を触知し,腹部CT上,腫瘤は膵頭部付近に存在し表面平滑で造影効果を伴う被膜を有した。確定診断目的にEUS-FNA施行,細胞診で血管間質を伴い,乳頭状構造を呈し結合性の低下した細胞集団を認め,solid-pseudopapillay tumorと診断,膵頭十二指腸切除術が施行された。EUS-FNAは膵由来の腫瘍が疑われる病変の確定診断に有用であり,治療法決定に役立つものと考えられた。
  • Matsumoto Satohiro, Ikeya Takashi, Ikeda Masatosi, Ushimaru Shinya, Takamatsu Toru, Miyatani Hiroyuki, Yoshida Yukiko, Nokubi Mitsuhiro
    Progress of Digestive Endoscopy(1972) Japan Gastroenterological Endoscopy Society Kanto Chapter 74 (2) 80 - 81 1348-9844 2009 
    症例は60歳,男性。主訴は左下腹部痛。前医で施行された腹部CTにて小腸腫瘍が疑われ,当科紹介入院となった。経口ダブルバルーン(DB)小腸内視鏡にて回腸に全周性狭窄を認めた。生検では確定診断が得られず,腹腔鏡下小腸部分切除術を施行。病理組織学所見にてMALTリンパ腫と診断した。今回我々は,回腸MALTリンパ腫をDB小腸内視鏡にて確認しえたので報告する。
  • Satohiro Matsumoto, Kazumi Yamasaki, Kenichiro Tsuji, Satoshi Shirahama
    Journal of Infectious Diseases 198 (1) 10 - 15 0022-1899 2008/07 [Refereed][Not invited]
     
    Background. The rate of human T lymphotropic virus type 1 (HTLV-1) positivity among residents of Kamigoto, Japan, is extremely high (15%). Although the rate of Helicobacter pylori positivity in Kamigoto is almost the same as that in other areas of Japan, the incidence of gastric cancer in Kamigoto is lower. This study examined whether HTLV-1 infection affects H. pylori infection and the development of gastric cancer. Methods. The study involved 5686 patients > 40 years of age who provided serum specimens for HTLV-1 antibody testing during 1989-1992. A total of 1812 patients underwent gastric endoscopy during the follow-up period. Of these, 497 were HTLV-1 seropositive. Data for these patients were compared with those for 497 HTLV-1-seronegative control patients matched for age, sex, and follow-up duration. We followed these groups until 2003 and determined the cumulative incidence rate of gastric cancer. Results. The rate of H. pylori positivity was 61.7% in the HTLV-1-positive group and 71.6% in the HTLV-1-negative group (P = .07). Fourteen HTLV-1-positive patients (2.8%) had gastric cancer, compared with 35 patients (7.0%) in the HTLV-1-negative group (odds ratio, 0.38 95% confidence interval, 0.21- 0.70 P = .0028). Conclusion. HTLV-1 infection likely reduces the risk of H. pylori infection and proliferation and, thereby, the risk of gastric cancer. © 2008 by the Infectious Diseases Society of America. All rights reserved.
  • Satohiro Matsumoto, Kenichiro Tsuji, Satoshi Shirahama
    WORLD JOURNAL OF GASTROENTEROLOGY 14 (25) 4059 - 4064 1007-9327 2008/07 [Refereed][Not invited]
     
    AIM: To attempt rectal administration of rebamipide in the treatment of ischemic colitis patients with ulcers, and evaluate its effects. METHODS: We compared 9 ischemic colitis patients (2 men, 7 women) with ulcers treated by bowel rest only from 2000 to 2005 (conventional therapy group), with 6 patients (2 men, 4 women) treated by rebamipide enema therapy in 2006 (rebamipide enema therapy group) and analyzed the mean duration of fasting and hospitalization, degree of ulcer healing, and decrease in WBC count for the two groups. RESULTS: The mean duration of fasting and hospitalization were 2.7 +/- 1.8 d and 9.2 +/- 1.5 d in the rebamipide group and 7.9 +/- 4.1 d and 17.9 +/- 6.8 d in the control group, respectively, and significantly reduced in the rebamipide group (t = -2.915; P = 0.0121 and t = -3.054; P = 0.0092). As for the degree of ulcer healing at 7 d after admission, the ulcer score was reduced by 3.5 +/- 0.5 (points) in the rebamipide group and 2.8 +/- 0.5 (points) in the control group (t = 1.975; P = 0.0797), while the decrease in WBC count was 120.0 +/- 55.8 (x 10(2) /mu L) in the rebampide group and 85.9 +/- (x 10(2)/mu L) in the control group (t = 1.006; P = 0.3360). CONCLUSION: In left-sided ischemic colitis patients with ulcers, rebamipide enema therapy significantly reduced the duration of fasting and hospitalization, recommending its use as a new and effective therapeutic alternative.(C) 2008 The WJG Press. All rights reserved.
  • Satohiro Matsumoto, Kazumi Yamasaki, Kenichiro Tsuji, Satoshi Shirahama
    JOURNAL OF INFECTIOUS DISEASES 198 (1) 10 - 15 1537-6613 2008/07 [Refereed][Not invited]
     
    Background. The rate of human T lymphotropic virus type 1 (HTLV-1) positivity among residents of Kamigoto, Japan, is extremely high (15%). Although the rate of Helicobacter pylori positivity in Kamigoto is almost the same as that in other areas of Japan, the incidence of gastric cancer in Kamigoto is lower. This study examined whether HTLV-1 infection affects H. pylori infection and the development of gastric cancer. Methods. The study involved 5686 patients > 40 years of age who provided serum specimens for HTLV-1 antibody testing during 1989-1992. A total of 1812 patients underwent gastric endoscopy during the follow-up period. Of these, 497 were HTLV-1 seropositive. Data for these patients were compared with those for 497 HTLV-1-seronegative control patients matched for age, sex, and follow-up duration. We followed these groups until 2003 and determined the cumulative incidence rate of gastric cancer. Results. The rate of H. pylori positivity was 61.7% in the HTLV-1-positive group and 71.6% in the HTLV-1 negative group (P = .07). Fourteen HTLV-1-positive patients (2.8%) had gastric cancer, compared with 35 patients (7.0%) in the HTLV-1-negative group (odds ratio, 0.38; 95% confidence interval, 0.21-0.70; P = .0028). Conclusion. HTLV-1 infection likely reduces the risk of H. pylori infection and proliferation and, thereby, the risk of gastric cancer.
  • Satohiro Matsumoto, Kazumi Yamasaki, Kenichiro Tsuji, Satoshi Shirahama
    WORLD JOURNAL OF GASTROENTEROLOGY 13 (32) 4316 - 4320 1007-9327 2007/08 [Refereed][Not invited]
     
    AIM: To examine how the introduction of endoscopy to gastric cancer screening affected survival prognosis in a regional population. METHODS: The subjects comprised 4261 residents of Kamigoto, Nagasaki Prefecture, who underwent gastric X-ray examination for gastric cancer screening from 1991 to 1995, and all 7178 residents who underwent endoscopic examination for the same purpose from 1996 to 2003. The analysis evaluated trends in age-adjusted gastric cancer mortality rates and standard mortality ratios (SMRs) among the Kamigoto residents. RESULTS: According to demographic statistics, the 1995 and 2000 age-adjusted gastric cancer mortality rates in Nagasaki Prefecture (per 100000 population) were 42.6 and 37.3 for males and 18.6 and 16.0 for females, while the corresponding rates in Kamigoto before and after the introduction of endoscopic screening were respectively 51.9 and 28.0, and 26.6 and 6.9. The data obtained in this study were divided into those for two periods, 1990-1996 and 1997-2006, and SMRs were calculated separately for males and females. For the first period, the SMR was 1.04 (95% CI 0.50-1.58) for males and 1.54 (95% CI 0.71-2.38) for females, while for the second period the SMR was 0.71 (95% CI 0.33-1.10) for males and 0.62 (95% CI 0.19-1.05) for females. CONCLUSION: Following the introduction of endoscopic examination, gastric cancer death rates decreased in Kamigoto. (c) 2007 WJG. All rights reserved.
  • Satohiro Matsumoto, Kenichiro Tsuji, Satoshi Shirahama
    WORLD JOURNAL OF GASTROENTEROLOGY 13 (8) 1236 - 1239 1007-9327 2007/02 [Refereed][Not invited]
     
    AIM: To investigate the relationship among the presence of ulcer lesions, underlying disease, and clinical course in patients with ischemic colitis. METHODS: The subjects were 41 patients (10 male and 31 female; mean age 70 years) with ischemic colitis who were admitted to and received treatment in our hospital from 2000 to 2006. We compared their characteristics and analyzed the mean lengths of admission and fasting for 9 patients with ulcer lesions (ulcer group) and 32 without (non-ulcer group). RESULTS: The groups with presence and absence of ulcer differed significantly only in white blood cell (WBC) count. Lengths of fasting and admission were 7.9 d and 17.9 d for the ulcer group and 4.4 d and 10.7 d for the non-ulcer group, respectively, and significantly longer in the ulcer group (P = 0.0057 and 0.0001). There was no correlation between presence of ulcer and presence of underlying diseases. CONCLUSION: Lengths of fasting and admission were significantly longer in patients with ischemic colitis with ulcer than for those without ulcer. (C) 2007 The WJG Press. All rights reserved.

MISC

  • Hirosato Mashima, Noboru Watanabe, Masanari Sekine, Takeharu Asano, Takeshi Uehara, Shunsuke Urayoshi, Kenichi Yamanaka, Satohiro Matsumoto, Noriyoshi Sagihara, Shinichi Asabe, Hiroyuki Miyatani, Hirohide Ohnishi  GASTROENTEROLOGY  152-  (5)  S1038  -S1038  2017/04  [Not refereed][Not invited]
  • Toru Takamatsu, Takeshi Uehara, Takashi Ikeya, Kouichi Toukai, Masatoshi Ikeda, Shinya Ushimaru, Takeharu Asano, Satohiro Matsumoto, Takaaki Iwaki, Masanori Fukunishi, Noriyoshi Sagihara, Shinichi Asabe, Hiroyuki Miyatani, Yukio Yoshida, Hiroshi Noda, Hiroshi Dobashi  PANCREAS  40-  (5)  804  -804  2011/07  [Not refereed][Not invited]

Awards & Honors

  • 2019/06 日本消化器がん検診学会 第37回有賀記念学会賞
  • 2018/04 第2回地域医療奨励賞
  • 2013/06 日本消化器がん検診学会 第11回 学術奨励賞
     
    受賞者: 松本 吏弘


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