niki toshiro

FacultyDepartmentofPathology,DivisionofIntegrativePathology
Job titleProfessorWeb site

Profile

Research Keywords

    Lung cancer, Molecular target therapy, Epithelial-stromal interaction, Fibroblast, Microenvironment

Research Areas

  • Basic medicine / Human pathology

Career

  • Jichi Medical University, Professor
  • 1987
    -
    1990
    Research Associate, University of Tokyo
  • 1991
    -
    1996
    Research Fellow, Free University of Brussel
  • 1997
    -
    2000
    Research Staff, National Cancer Center
  • 2001
    -
    2004
    Associate Prof., University of Tokyo
  • 2005
    -
    Today
    Professor, Jichi Medical University

Academic Background

  • -
    1986
    Human Pathology, Graduate School, Division of Medical Sciences, The University of Tokyo (japan)
  • -
    1983
    school of Medicine, Faculty of Medicine, The University of Tokyo (japan)

Academic Societies

  • The Japanese Society of Pathology
  • The Japanese Society of Clinical Cytology
  • The Japan Lung Cancer Society
  • The Japan Cancer Association
  • The Japan Society of Pathology
  • The American Association for Cancer Research
  • International Association for the Study of Lung Cancer
Display all
Academic Societiesclose
  • The Japanese Society of Pathology
  • The Japanese Society of Clinical Cytology
  • The Japan Lung Cancer Society
  • The Japan Cancer Association
  • The Japan Society of Pathology
  • The American Association for Cancer Research
  • International Association for the Study of Lung Cancer

Research Activities

Papers(paper)

  • Hepatocellular nodules resulting from congenital extrahepatic portosystemic shunts can differentiate into potentially malignant hepatocellular adenomas.
    Sanada Y, Mizuta K, Niki T, Tashiro M, Hirata Y, Okada N, Yamada N, Ihara Y, Urahashi T, Soejima Y, Fukusato T, Kondo F
    Journal of hepato-biliary-pancreatic sciences Jul. 2015
  • The role of HGF/MET and FGF/FGFR in fibroblast-derived growth stimulation and lapatinib-resistance of esophageal squamous cell carcinoma.
    Saito S, Morishima K, Ui T, Hoshino H, Matsubara D, Ishikawa S, Aburatani H, Fukayama M, Hosoya Y, Sata N, Lefor AK, Yasuda Y, Niki T
    BMC cancer 15 82 Feb. 2015
  • Immunohistochemical analysis of the expression of E-cadherin and ZEB1 in non-small cell lung cancer.
    Matsubara D, Kishaba Y, Yoshimoto T, Sakuma Y, Sakatani T, Tamura T, Endo S, Sugiyama Y, Murakami Y, Niki T
    Pathology international 64(11) 560-568 Nov. 2014
  • Preserved or enhanced OATP1B3 expression in hepatocellular adenoma subtypes with nuclear accumulation of β-catenin.
    Fukusato T, Soejima Y, Kondo F, Inoue M, Watanabe M, Takahashi Y, Aso T, Uozaki H, Sano K, Sanada Y, Niki T
    Hepatology research : the official journal of the Japan Society of Hepatology Nov. 2014
  • Stromal fibroblasts are predictors of disease-related mortality in esophageal squamous cell carcinoma.
    Saito S, Morishima K, Ui T, Matsubara D, Tamura T, Oguni S, Hosoya Y, Sata N, Lefor AT, Yasuda Y, Niki T
    Oncology reports 32 348-354 Jul. 2014
  • The HSP90 inhibitor 17-N-allylamino-17-demethoxy geldanamycin (17-AAG) synergizes with cisplatin and induces apoptosis in cisplatin-resistant esophageal squamous cell carcinoma cell lines via the Akt/XIAP pathway.
    Ui T, Morishima K, Saito S, Sakuma Y, Fujii H, Hosoya Y, Ishikawa S, Aburatani H, Fukayama M, Niki T, Yasuda Y
    Oncology reports 31 619-624 Feb. 2014
  • Expression of PRMT5 in lung adenocarcinoma and its significance in epithelial-mesenchymal transition.
    Ibrahim R, Matsubara D, Osman W, Morikawa T, Goto A, Morita S, Ishikawa S, Aburatani H, Takai D, Nakajima J, Fukayama M, Niki T, Murakami Y
    Human pathology Feb. 2014
  • Enhanced autophagy is required for survival in EGFR-independent EGFR-mutant lung adenocarcinoma cells.
    Sakuma Y, Matsukuma S, Nakamura Y, Yoshihara M, Koizume S, Sekiguchi H, Saito H, Nakayama H, Kameda Y, Yokose T, Oguni S, Niki T, Miyagi Y
    Laboratory investigation; a journal of technical methods and pathology 93 1137-1146 Oct. 2013
  • Lung cancer with loss of BRG1/BRM, shows epithelial mesenchymal transition phenotype and distinct histologic and genetic features.
    Matsubara D, Kishaba Y, Ishikawa S, Sakatani T, Oguni S, Tamura T, Hoshino H, Sugiyama Y, Endo S, Murakami Y, Aburatani H, Fukayama M, Niki T
    Cancer science 104 266-273 Feb. 2013
  • Identification of CCDC6-RET fusion in the human lung adenocarcinoma cell line, LC-2/ad.
    Matsubara D, Kanai Y, Ishikawa S, Ohara S, Yoshimoto T, Sakatani T, Oguni S, Tamura T, Kataoka H, Endo S, Murakami Y, Aburatani H, Fukayama M, Niki T
    Journal of thoracic oncology : official publication of the International Association for the Study of Lung Cancer 7 1872-1876 Dec. 2012
Display all
Papers(paper)close
  • Hepatocellular nodules resulting from congenital extrahepatic portosystemic shunts can differentiate into potentially malignant hepatocellular adenomas.
    Sanada Y, Mizuta K, Niki T, Tashiro M, Hirata Y, Okada N, Yamada N, Ihara Y, Urahashi T, Soejima Y, Fukusato T, Kondo F
    Journal of hepato-biliary-pancreatic sciences Jul. 2015
  • The role of HGF/MET and FGF/FGFR in fibroblast-derived growth stimulation and lapatinib-resistance of esophageal squamous cell carcinoma.
    Saito S, Morishima K, Ui T, Hoshino H, Matsubara D, Ishikawa S, Aburatani H, Fukayama M, Hosoya Y, Sata N, Lefor AK, Yasuda Y, Niki T
    BMC cancer 15 82 Feb. 2015
  • Immunohistochemical analysis of the expression of E-cadherin and ZEB1 in non-small cell lung cancer.
    Matsubara D, Kishaba Y, Yoshimoto T, Sakuma Y, Sakatani T, Tamura T, Endo S, Sugiyama Y, Murakami Y, Niki T
    Pathology international 64(11) 560-568 Nov. 2014
  • Preserved or enhanced OATP1B3 expression in hepatocellular adenoma subtypes with nuclear accumulation of β-catenin.
    Fukusato T, Soejima Y, Kondo F, Inoue M, Watanabe M, Takahashi Y, Aso T, Uozaki H, Sano K, Sanada Y, Niki T
    Hepatology research : the official journal of the Japan Society of Hepatology Nov. 2014
  • Stromal fibroblasts are predictors of disease-related mortality in esophageal squamous cell carcinoma.
    Saito S, Morishima K, Ui T, Matsubara D, Tamura T, Oguni S, Hosoya Y, Sata N, Lefor AT, Yasuda Y, Niki T
    Oncology reports 32 348-354 Jul. 2014
  • The HSP90 inhibitor 17-N-allylamino-17-demethoxy geldanamycin (17-AAG) synergizes with cisplatin and induces apoptosis in cisplatin-resistant esophageal squamous cell carcinoma cell lines via the Akt/XIAP pathway.
    Ui T, Morishima K, Saito S, Sakuma Y, Fujii H, Hosoya Y, Ishikawa S, Aburatani H, Fukayama M, Niki T, Yasuda Y
    Oncology reports 31 619-624 Feb. 2014
  • Expression of PRMT5 in lung adenocarcinoma and its significance in epithelial-mesenchymal transition.
    Ibrahim R, Matsubara D, Osman W, Morikawa T, Goto A, Morita S, Ishikawa S, Aburatani H, Takai D, Nakajima J, Fukayama M, Niki T, Murakami Y
    Human pathology Feb. 2014
  • Enhanced autophagy is required for survival in EGFR-independent EGFR-mutant lung adenocarcinoma cells.
    Sakuma Y, Matsukuma S, Nakamura Y, Yoshihara M, Koizume S, Sekiguchi H, Saito H, Nakayama H, Kameda Y, Yokose T, Oguni S, Niki T, Miyagi Y
    Laboratory investigation; a journal of technical methods and pathology 93 1137-1146 Oct. 2013
  • Lung cancer with loss of BRG1/BRM, shows epithelial mesenchymal transition phenotype and distinct histologic and genetic features.
    Matsubara D, Kishaba Y, Ishikawa S, Sakatani T, Oguni S, Tamura T, Hoshino H, Sugiyama Y, Endo S, Murakami Y, Aburatani H, Fukayama M, Niki T
    Cancer science 104 266-273 Feb. 2013
  • Identification of CCDC6-RET fusion in the human lung adenocarcinoma cell line, LC-2/ad.
    Matsubara D, Kanai Y, Ishikawa S, Ohara S, Yoshimoto T, Sakatani T, Oguni S, Tamura T, Kataoka H, Endo S, Murakami Y, Aburatani H, Fukayama M, Niki T
    Journal of thoracic oncology : official publication of the International Association for the Study of Lung Cancer 7 1872-1876 Dec. 2012
  • Pathological responses and survival of patients with human epidermal growth factor receptor 2-positive breast cancer who received neoadjuvant chemotherapy including trastuzumab.
    Ohzawa H, Sakatani T, Niki T, Yasuda Y, Hozumi Y
    Breast cancer (Tokyo, Japan) Oct. 2012
  • A clinicopathological and immunohistochemical study of gastric cancer with squamous cell carcinoma components: a clinically aggressive tumor.
    Saito S, Hosoya Y, Morishima K, Ui T, Haruta H, Kurashina K, Meguro Y, Zuiki T, Sata N, Fujii H, Matsubara D, Niki T, Lefor AT, Yasuda Y
    Journal of digestive diseases 13 407-413 Aug. 2012
  • Epidermal growth factor receptor mutation and chemosensitivity.
    Matsubara D, Niki T
    Journal of thoracic oncology : official publication of the International Association for the Study of Lung Cancer 7 771-2; author reply 772 Apr. 2012
  • Human papillomavirus infection in lung and esophageal cancers: analysis of 485 Asian cases.
    Goto A, Li CP, Ota S, Niki T, Ohtsuki Y, Kitajima S, Yonezawa S, Koriyama C, Akiba S, Uchima H, Lin YM, Yeh KT, Koh JS, Kim CW, Kwon KY, Nga ME, Fukayama M
    Journal of medical virology 83 1383-1390 Aug. 2011
  • Lung adenocarcinoma, mixed subtype: histopathologic basis for high-resolution computed tomography findings.
    Terasaki H, Kato S, Matsuno Y, Kusumoto M, Niki T, Hayashi A, Terasaki K, Hayabuchi N
    Journal of thoracic imaging 26 74-81 Feb. 2011
  • Co-activation of epidermal growth factor receptor and c-MET defines a distinct subset of lung adenocarcinomas.
    Matsubara D, Ishikawa S, Sachiko O, Aburatani H, Fukayama M, Niki T
    The American journal of pathology 177 2191-2204 Nov. 2010
  • Molecular predictors of sensitivity to the MET inhibitor PHA665752 in lung carcinoma cells.
    Matsubara D, Ishikawa S, Oguni S, Aburatani H, Fukayama M, Niki T
    Journal of thoracic oncology : official publication of the International Association for the Study of Lung Cancer 5 1317-1324 Sep. 2010
  • Pleomorphic phenotypes of gastrointestinal stromal tumors at metastatic sites with or without imatinib treatment.
    Sakamoto K, Sakurai S, Kanda T, Sakuma Y, Hishima T, Hironaka M, Bamba T, Keira Y, Takano Y, Niki T, Hasegawa T, Hirota S
    Cancer science 101 1270-1278 May 2010
  • Heterogeneous expression of nestin in myofibroblasts of various human tissues.
    Kishaba Y, Matsubara D, Niki T
    Pathology international 60 378-385 May 2010
  • Subepithelial myofibroblast in lung adenocarcinoma: a histological indicator of excellent prognosis.
    Matsubara D, Morikawa T, Goto A, Nakajima J, Fukayama M, Niki T
    Modern pathology : an official journal of the United States and Canadian Academy of Pathology, Inc 22 776-785 Jun. 2009
  • Clinicopathological study of lymph-node metastasis in 1,389 patients with early gastric cancer: assessment of indications for endoscopic resection.
    Haruta H, Hosoya Y, Sakuma K, Shibusawa H, Satoh K, Yamamoto H, Tanaka A, Niki T, Sugano K, Yasuda Y
    Journal of digestive diseases 9 213-218 Nov. 2008
  • Constitutive activation of c-Met is correlated with c-Met overexpression and dependent on cell-matrix adhesion in lung adenocarcinoma cell lines.
    Nakamura Y, Matsubara D, Goto A, Ota S, Sachiko O, Ishikawa S, Aburatani H, Miyazawa K, Fukayama M, Niki T
    Cancer science 99 14-22 Jan. 2008
  • EML4-ALK fusion is linked to histological characteristics in a subset of lung cancers.
    Inamura K, Takeuchi K, Togashi Y, Nomura K, Ninomiya H, Okui M, Satoh Y, Okumura S, Nakagawa K, Soda M, Choi YL, Niki T, Mano H, Ishikawa Y
    Journal of thoracic oncology : official publication of the International Association for the Study of Lung Cancer 3 13-17 Jan. 2008
  • AKR1B10 in usual interstitial pneumonia: expression in squamous metaplasia in association with smoking and lung cancer.
    Li CP, Goto A, Watanabe A, Murata K, Ota S, Niki T, Aburatani H, Fukayama M
    Pathology, research and practice 204 295-304 2008
  • p63 - Key molecule in the early phase of epithelial abnormality in idiopathic pulmonary fibrosis.
    Murata K, Ota S, Niki T, Goto A, Li CP, Ruriko UM, Ishikawa S, Aburatani H, Kuriyama T, Fukayama M
    Experimental and molecular pathology 83 367-376 Dec. 2007
  • c-Met activation in lung adenocarcinoma tissues: an immunohistochemical analysis.
    Nakamura Y, Niki T, Goto A, Morikawa T, Miyazawa K, Nakajima J, Fukayama M
    Cancer science 98 1006-1013 Jul. 2007
  • Hypoxia increases the motility of lung adenocarcinoma cell line A549 via activation of the epidermal growth factor receptor pathway.
    Wang T, Niki T, Goto A, Ota S, Morikawa T, Nakamura Y, Ohara E, Ishikawa S, Aburatani H, Nakajima J, Fukayama M
    Cancer science 98 506-511 Apr. 2007
  • The glypican 3 oncofetal protein is a promising diagnostic marker for hepatocellular carcinoma.
    Yamauchi N, Watanabe A, Hishinuma M, Ohashi K, Midorikawa Y, Morishita Y, Niki T, Shibahara J, Mori M, Makuuchi M, Hippo Y, Kodama T, Iwanari H, Aburatani H, Fukayama M
    Modern pathology : an official journal of the United States and Canadian Academy of Pathology, Inc 18 1591-1598 Dec. 2005
  • Differential expression of S100A2 and S100A4 in lung adenocarcinomas: clinicopathological significance, relationship to p53 and identification of their target genes.
    Matsubara D, Niki T, Ishikawa S, Goto A, Ohara E, Yokomizo T, Heizmann CW, Aburatani H, Moriyama S, Moriyama H, Nishimura Y, Funata N, Fukayama M
    Cancer science 96 844-857 Dec. 2005
  • Soft and hard keratin expression in Epstein-Barr-virus-associated gastric carcinoma.
    Uozaki H, Chong JM, Fujimoto E, Itoh M, Saito M, Sakuma K, Sudo M, Ushiku T, Niki T, Nagai H, Takada K, Fukayama M
    Anticancer research 25 3183-3190 Sep. 2005
  • Loss of TSLC1 expression in lung adenocarcinoma: relationships with histological subtypes, sex and prognostic significance.
    Goto A, Niki T, Chi-Pin L, Matsubara D, Murakami Y, Funata N, Fukayama M
    Cancer science 96 480-486 Aug. 2005
  • Overexpression of the aldo-keto reductase family protein AKR1B10 is highly correlated with smokers' non-small cell lung carcinomas.
    Fukumoto S, Yamauchi N, Moriguchi H, Hippo Y, Watanabe A, Shibahara J, Taniguchi H, Ishikawa S, Ito H, Yamamoto S, Iwanari H, Hironaka M, Ishikawa Y, Niki T, Sohara Y, Kodama T, Nishimura M, Fukayama M, Dosaka-Akita H, Aburatani H
    Clinical cancer research : an official journal of the American Association for Cancer Research 11 1776-1785 Mar. 2005
  • Lung adenocarcinoma associated with familial adenomatous polyposis. Clear cell carcinoma with beta-catenin accumulation accompanied by atypical adenomatous hyperplasia.
    Goto A, Nakajima J, Hara K, Niki T, Fukayama M
    Virchows Archiv : an international journal of pathology 446 73-77 Jan. 2005
  • Immunohistochemical study of Skp2 and Jab1, two key molecules in the degradation of P27, in lung adenocarcinoma.
    Goto A, Niki T, Moriyama S, Funata N, Moriyama H, Nishimura Y, Tsuchida R, Kato JY, Fukayama M
    Pathology international 54 675-681 Sep. 2004
  • Primary pulmonary paraganglioma: report of a functioning case with immunohistochemical and ultrastructural study.
    Shibahara J, Goto A, Niki T, Tanaka M, Nakajima J, Fukayama M
    The American journal of surgical pathology 28 825-829 Jun. 2004
  • Lung adenocarcinoma associated with atypical adenomatous hyperplasia. A clinicopathological study with special reference to smoking and cancer multiplicity.
    Kitagawa H, Goto A, Niki T, Hironaka M, Nakajima J, Fukayama M
    Pathology international 53 823-827 Dec. 2003
  • Lung adenocarcinoma with mixed bronchioloalveolar and invasive components: clinicopathological features, subclassification by extent of invasive foci, and immunohistochemical characterization.
    Terasaki H, Niki T, Matsuno Y, Yamada T, Maeshima A, Asamura H, Hayabuchi N, Hirohashi S
    The American journal of surgical pathology 27 937-951 Jul. 2003
  • Sclerosing hemangioma of the lung with cystic appearance.
    Kitagawa H, Goto A, Minami M, Nakajima J, Niki T, Fukayama M
    Japanese journal of clinical oncology 33 360-363 Jul. 2003
  • Modified scar grade: a prognostic indicator in small peripheral lung adenocarcinoma.
    Maeshima AM, Niki T, Maeshima A, Yamada T, Kondo H, Matsuno Y
    Cancer 95 2546-2554 Dec. 2002
  • MYO18B, a candidate tumor suppressor gene at chromosome 22q12.1, deleted, mutated, and methylated in human lung cancer.
    Nishioka M, Kohno T, Tani M, Yanaihara N, Tomizawa Y, Otsuka A, Sasaki S, Kobayashi K, Niki T, Maeshima A, Sekido Y, Minna JD, Sone S, Yokota J
    Proceedings of the National Academy of Sciences of the United States of America 99 12269-12274 Sep. 2002
  • Large cell neuroendocrine carcinoma of the lung: a clinicopathologic study of eighty-seven cases.
    Takei H, Asamura H, Maeshima A, Suzuki K, Kondo H, Niki T, Yamada T, Tsuchiya R, Matsuno Y
    The Journal of thoracic and cardiovascular surgery 124 285-292 Aug. 2002
  • Trichostatin A, a histone deacetylase inhibitor, suppresses collagen synthesis and prevents TGF-beta(1)-induced fibrogenesis in skin fibroblasts.
    Rombouts K, Niki T, Greenwel P, Vandermonde A, Wielant A, Hellemans K, De Bleser P, Yoshida M, Schuppan D, Rojkind M, Geerts A
    Experimental cell research 278 184-197 Aug. 2002
  • Clinicopathological significance of epigenetic inactivation of RASSF1A at 3p21.3 in stage I lung adenocarcinoma.
    Tomizawa Y, Kohno T, Kondo H, Otsuka A, Nishioka M, Niki T, Yamada T, Maeshima A, Yoshimura K, Saito R, Minna JD, Yokota J
    Clinical cancer research : an official journal of the American Association for Cancer Research 8 2362-2368 Jul. 2002
  • Frequent co-localization of Cox-2 and laminin-5 gamma2 chain at the invasive front of early-stage lung adenocarcinomas.
    Niki T, Kohno T, Iba S, Moriya Y, Takahashi Y, Saito M, Maeshima A, Yamada T, Matsuno Y, Fukayama M, Yokota J, Hirohashi S
    The American journal of pathology 160 1129-1141 Mar. 2002

Papers(other)

  • Comparison of preoperative chemotherapy using docetaxel, cisplatin and fluorouracil with cisplatin and fluorouracil in patients with advanced carcinoma of the thoracic esophagus
    T. Ui, H. Fujii, Y. Hosoya, M. Nagase, M. N. Mieno, M. Mori, T. Zuiki, S. Saito, K. Kurashina, H. Haruta, S. Matsumoto, T. Niki, A. Lefor, Y. Yasuda
    Diseases of the Esophagus 28 180-187 Jan. 2015
  • Insulin-like growth factor-II/mannose 6-phosphate receptor is expressed on CCl4-exposed rat fat-storing cells and facilitates activation of latent transforming growth factor-beta in cocultures with sinusoidal endothelial cells.
    Hepatology 21, 1429-1437 1995
  • Comparison of glial fibrillary acidic protein and desmin staining in normal and CCl4-induced fibrotic rat livers.
    Hepatology 23, 1538-1545 1996
  • Dexamethasone alters messenger RNA levels but not synthesis of collagens, fibronectin, or laminin by cultured rat fat-storing cells.
    Hepatology 23, 1673-1681 1996
  • Insulin-like growth factor II/mannose 6-phosphate-receptor expression in liver and serum during acute CCl4 intoxication in the rat.
    Hepatology 23, 1530-1537 1996
  • Localization and cellular sources of activins in normal and fibrotic rat liver.
    Hepatology 26, 905-912 1997
  • Transforming growth factor-beta gene expression in normal and fibrotic rat liver.
    J Hepatol 26, 886-893 1997
  • Gene expression and synthesis of fibronectin isoforms in rat hepatic stellate cells. Comparison with liver parenchymal cells and skin fibroblasts.
    J Pathol 183, 90-98. 1997
  • Van den Winkel M. Purification of rat hepatic stellate cells by side scatter-activated cell sorting.
    Hepatology 27, 590-598 1998
  • Class VI intermediate filament protein nestin is induced during activation of rat hepatic stellate cells.
    Hepatology 29, 520-527 1999
Display all
Papers(other)close
  • Comparison of preoperative chemotherapy using docetaxel, cisplatin and fluorouracil with cisplatin and fluorouracil in patients with advanced carcinoma of the thoracic esophagus
    T. Ui, H. Fujii, Y. Hosoya, M. Nagase, M. N. Mieno, M. Mori, T. Zuiki, S. Saito, K. Kurashina, H. Haruta, S. Matsumoto, T. Niki, A. Lefor, Y. Yasuda
    Diseases of the Esophagus 28 180-187 Jan. 2015
  • Insulin-like growth factor-II/mannose 6-phosphate receptor is expressed on CCl4-exposed rat fat-storing cells and facilitates activation of latent transforming growth factor-beta in cocultures with sinusoidal endothelial cells.
    Hepatology 21, 1429-1437 1995
  • Comparison of glial fibrillary acidic protein and desmin staining in normal and CCl4-induced fibrotic rat livers.
    Hepatology 23, 1538-1545 1996
  • Dexamethasone alters messenger RNA levels but not synthesis of collagens, fibronectin, or laminin by cultured rat fat-storing cells.
    Hepatology 23, 1673-1681 1996
  • Insulin-like growth factor II/mannose 6-phosphate-receptor expression in liver and serum during acute CCl4 intoxication in the rat.
    Hepatology 23, 1530-1537 1996
  • Localization and cellular sources of activins in normal and fibrotic rat liver.
    Hepatology 26, 905-912 1997
  • Transforming growth factor-beta gene expression in normal and fibrotic rat liver.
    J Hepatol 26, 886-893 1997
  • Gene expression and synthesis of fibronectin isoforms in rat hepatic stellate cells. Comparison with liver parenchymal cells and skin fibroblasts.
    J Pathol 183, 90-98. 1997
  • Van den Winkel M. Purification of rat hepatic stellate cells by side scatter-activated cell sorting.
    Hepatology 27, 590-598 1998
  • Class VI intermediate filament protein nestin is induced during activation of rat hepatic stellate cells.
    Hepatology 29, 520-527 1999
  • A histone deacetylase inhibitor, trichostatin A, suppresses myofibroblastic differentiation of rat hepatic stellate cells in primary culture.
    Hepatology 29, 858-867 1999
  • Clinicopathologic significance of laminin-5 gamma2 chain expression in squamous cell carcinoma of the tongue. Immunohistochemical analysis of 67 lesions.
    Cancer 85, 2315-2321 1999
  • Identification of a 428-kb homozygously deleted region disrupting the SEZ6L gene at 22ql2.1 in a lung cancer cell line.
    Oncogene 19, 6251-6260 2000
  • Altered expression of the ERM proteins in lung adenocarcinoma.
    Lab Invest 80, 1643-1650 2000
  • Differential expression of the LAMB3 and LAMC2 genes between small cell and non-small cell lung carcinomas.
    Biochem Biophys Res Commun 275, 440-445 2000
  • Expression of vascular endothelial growth factors A, B, C, and D and their relationships to lymph node status in lung adenocarcinoma.
    Clin Cancer Res 6, 2431 -2439 2000
  • Increased expression of laminin-5 and its prognostic significance in small-sized lung adenocarcinoma: an immunohistochemical analysis of 102 cases.
    Cancer 91, 1129-1141 2001
  • Expression of vascular endothelial growth factor receptor 3 in blood and lymphatic vessels of lung adenocarcinoma.
    J Pathol 193, 450-457 2001
  • c-MET expression in myofibroblasts: role in autocrine activation and prognostic significance in lung adenocarcinoma.
    Am J Pathol 158, 1451-1463 2001
  • Formation of normal desmin intermediate filaments in mouse hepatic stellate cells requires vimentin.
    Hepatology 33, 177-188 2001
  • Effect of aldosterone on collagen steady state levels in primary and subcultured rat hepatic stellate cells.
    J Hepatol 34, 230-8 2001
  • MY0l8B, a candidate tumor suppressor gene at chromosome 22ql2.l, deleted, mutated, and methylated in human lung cancer.
    Proc Natl Acad Sci U S A. 99, 12269-12274 2002
  • Trichostatin A, a histone deacetylase inhibitor, suppresses collagen synthesis and prevents TGF-beta(1)-induced fibrogenesis in skin fibroblasts.
    Exp Cell Res. 278, 184-197 2002
  • Modified scar grade: prognostic significance in small peripheral lung adenocarcinoma.
    Cancer in press 2002
  • Clinicopathological significance of epigenetic inactivation of RASSFIA at 3p2l.3 in stage I lung adenocarcinoma.
    Crin Cancer Res. 8, 2362-2368 2002
  • Frequent Co-Localization of Cox-2 and Laminin-s gamma2 Chain at the Invasive Front of Early-Stage Lung Adenocarcinomas.
    Am J Pathol 160,1129-1141 2002
  • Large cell neuroendocrine carcinoma of the lung: A clinicopathologic study of eighty-seven cases.
    Takei H, Asamura H, Maeshima A, Suzuki K, Kondo H, Niki T, Yamada T, Tsuchiya R, Matsuno Y.
    J Thorac Cardiovasc Surg. 124 285-292. 2002
  • Lung adenocarcinoma with mixed bronchiolo-alveolar and invasive components: clinicopathological features, subclassification by extent of invasive foci, and immunohistochemical characterization.
    Terasaki H, Niki T, Matsuno Y, Yamada T, Maeshima A, Asamura H, Hayabuchi N, Hirohashi S.
    Am J Surg Pathol 27 937-951. 2003
  • Sclerosing hemangioma of the lung with cystic appearance.
    Kitagawa H, Goto A, Minami M, Nakajima J, Niki T, Fukayama M.
    Jpn J Clin Oncol. 33(7) 360-363 2003
  • Lung adenocarcinoma associated with atypical adenomatous hyperplasia. A clinicopathological study with special reference to smoking and cancer multiplicity.
    Kitagawa H, Goto A, Niki T, Hironaka M, Nakajima J, Fukayama M.
    Pathol Int. 53(12) 823-827 2003
  • Primary pulmonary paraganglioma: report of a functioning case with immunohistochemical and ultrastructural study.
    Shibahara J, Goto A, Niki T, Tanaka M, Nakajima J, Fukayama M.
    Am J Surg Pathol. 28 825-829. 2004
  • Prevalence of CD99 protein expression in pancreatic endocrine tumours (PETS).
    Goto A, Niki T, Terado Y, Fukushima J, Fukayama M.
    Histopathology. 45 384-392. 2004
  • Immunohistochemical study of Skp2 and Jab1, two key molecules in the degradation of P27, in lung adenocarcinoma.
    Goto A, Niki T, Moriyama S, Funata N, Moriyama H, Nishimura Y, Tsuchida R, Kato JY, Fukayama M.
    Pathol Int. 54(9) 675-681 2004
  • Over-expression of the aldo-keto reductase family protein AKR1B10 is highly correlated with smokers’ non-small cell lung carcinomas.
    Fukumoto S, Yamauchi N, Moriguchi H, Hippo Y, Watanabe A, Shibahara J, Taniguchi H, Ishikawa S, Ito H, Yamamoto S, Iwanari H, Hironaka M, Ishikawa Y, Niki T, Sohara Y, Kodama T, Nishimura M, Fukayama M, Dosaka-Akita H, Aburatani H.
    Clin Cancer Res 11 1776-1785. 2005
  • Lung adenocarcinoma associated with familial adenomatous polyposis. Clear cell carcinoma with beta-catenin accumulation accompanied by atypical adenomatous hyperplasia.
    Goto A, Nakajima J, Hara K, Niki T, Fukayama M.
    Virchows Arch. 446 73-77. 2005
  • Soft and hard keratin expression in Epstein-Barr-virus-associated gastric carcinoma.
    Uozaki H, Chong JM, Fujimoto E, Itoh M, Saito M, Sakuma K, Sudo M, Ushiku T, Niki T, Nagai H, Takada K, Fukayama M.
    Anticancer Res. 25 3183-3190. 2005
  • Loss of TSLC1 expression in lung adenocarcinoma: Relationships with histological subtypes, sex and prognostic significance.
    Goto A, Niki T, Chi-Pin L, Matsubara D, Murakami Y, Funata N, Fukayama M.
    Cancer Sci. 96(8) 480-486 2005
  • The glypican 3 oncofetal protein is a promising diagnostic marker for hepatocellular carcinoma.
    Yamauchi N, Watanabe A, Hishinuma M, Ohashi KI, Midorikawa Y, Morishita Y, Niki T, Shibahara J, Mori M, Makuuchi M, Hippo Y, Kodama T, Iwanari H, Aburatani H, Fukayama M.
    Mod Pathol. 18 1591-8. 2005
  • Differential expression of S100A2 and S100A4 in lung adenocarcinomas: clinicopathologic significance, relationship to p53, and identification of their target genes.
    Matsubara D, Niki T, Ishikawa S, Goto A, Ohara E, Yokomizo T, Heizmann CW, Aburatani H, Moriyama S, Moriyama H, Nishimura Y, Funata N, Fukayama M
    Cancer Sci 96(12) 844-857 2005
  • Cytoplasmic localization of p63 is associated with poor patient survival in lung adenocarcinoma.
    Narahashi T, Niki T, Wang T, Goto A, Matsubara D, Funata N, Fukayama M
    Histopathology. 49 349-57 2006
  • Hypoxia increases the motility of lung adenocarcinoma cells A549 via activation of the epidermal growth factor receptor pathway.
    Wang T, Niki T, Goto A, Ota S, Morikawa T, Nakamura Y, Ohara E, Ishikawa S, Aburatani H, Nakajima J, Fukayama M.
    Cancer Sci 98(4) 506-511 2007
  • c-Met activation in lung adenocarcinoma tissues: an immunohistochemical analysis.
    Nakamura Y, Niki T, Goto A, Morikawa T, Miyazawa K, Nakajima J, Fukayama M.
    Cancer Sci. 98(7) 1006-1013 2007
  • p63 – key molecule in early phase of epithelial abnormality in idiopathic pulmonary fibrosis.
    Murata K, Ota S, Niki T, Goto A, Li C-P, Ruriko UMR, Ishikawa S, Aburatani H, Kuriyama T, Fukayama M.
    Exp Mol Pathol. 83 367-76 2007
  • Identification of the transforming EML4-ALK fusion gene in non-small-cell lung cancer.
    Soda M, Choi YL, Enomoto M, Takada S, Yamashita Y, Ishikawa S, Fujiwara S, Watanabe H, Kurashina K, Hatanaka H, Bando M, Ohno S, Ishikawa Y, Aburatani H, Niki T, Sohara Y, Sugiyama Y, Mano H
    Nature. 448(7153) 561-566 2007
  • Constitutive activation of c-Met is correlated with c-Met overexpression and dependent on cell-matrix adhesion in lung adenocarcinoma cell lines.
    Nakamura Y, Matsubara D, Goto A, Ota S, Oguni S, Ishikawa S, Aburatani H, Miyazawa K, Fukayama M, Niki T.
    Cancer Sci 99 14-22. 2008
  • EML4-ALK fusion is linked to histological characteristics in a subset of lung cancers.
    Inamura K, Takeuchi K, Togashi Y, Nomura K, Ninomiya H, Okui M, Satoh Y, Okumura S, Nakagawa K, Soda M, Lim CY, Niki T, Mano H, Ishikawa
    J Thorac Oncol. 3 13-7. 2008
  • AKR1B10 in usual interstitial pneumonia: Expression in squamous metaplasia in association with smoking and lung cancer.
    Li CP, Goto A, Watanabe A, Murata K, Ota S, Niki T, Aburatani H, Fukayama M.
    Pathol Res Pract. 2004 295-304. 2008
  • Clinicopathological study of lymph-node metastasis in 1,389 patients with early gastric cancer: assessment of indications for endoscopic resection.
    Haruta H, Hosoya Y, Sakuma K, Shibusawa H, Satoh K, Yamamoto H, Tanaka A, Niki T, Sugano K, Yasuda Y.
    J Dig Dis. 9 213-218. 2008
  • Subepithelial myofibroblast in lung adenocarcinoma: a histologic indicator of excellent prognosis.
    Matsubara D, Morikawa T, Goto A, Nakajima J, Fukayama M, Niki T.
    Mod Pathol 22 776-85. 2009

Outside Fund Adoption

  • Cancer and Wound Healing
    :Basic Science Research Program
    Project Year :1997 - 2020
  • Epithelial-Stromal Interaction
    :Basic Science Research Program
    Project Year :1997 - 2020
  • Microenvironment
    :Basic Science Research Program
    Project Year :1997 - 2020
Display all
Outside Fund Adoptionclose
  • Cancer and Wound Healing
    :Basic Science Research Program
    Project Year :1997 - 2020
  • Epithelial-Stromal Interaction
    :Basic Science Research Program
    Project Year :1997 - 2020
  • Microenvironment
    :Basic Science Research Program
    Project Year :1997 - 2020


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