okamoto hiroaki

FacultyInfectionandImmunityVirology
Job titleProfessorWeb site

Profile

Research Keywords

    Replication mechanism, Fulminant hepatitis, Anellovirus, Genetic mutation, Monoclonal antibody, Cell culture, Molecular epidemiology, Hepatitis C virus, Hepatitis delta virus, Hepatitis E virus, Zoonosis, Torque teno virus, GB virus, Molecular cloning, Hepatitis A virus, Hepatitis B virus , Hepatitis viruses, Viral Hepatitis, Molecular virology

Research Areas

  • Biological science / Molecular biology
  • Basic medicine / Virology

Career

  • Jichi Medical University, Professor
  • 1985
    -
    1987
    Jichi Medical School, Assistant
  • 1987
    -
    1998
    Jichi Medical School, Assistant Professor
  • 1998
    -
    2003
    JIchi Medical School, Associate Professor

Academic Background

  • -
    1979
    Faculty of Medicine, Tohoku University (japan)

Academic Societies

  • American Society for Microbiology
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  • American Society for Microbiology

Research Activities

Papers(paper)

  • Rat hepatitis E virus derived from wild rats (Rattus rattus) propagates efficiently in human hepatoma cell lines.
    Jirintai S, Tanggis, Mulyanto, Suparyatmo JB, Takahashi M, Kobayashi T, Nagashima S, Nishizawa T, Okamoto H
    Virus research 185 92-102 Jun. 2014
  • The origin of HCV genotype 3 in Africa as estimated through an evolutionary analysis of the full-length genomes of nine subtypes, including the newly sequenced 3d and 3e.
    Li C, Lu L, Murphy DG, Negro F, Okamoto H
    The Journal of general virology May 2014
  • The membrane on the surface of hepatitis E virus particles is derived from the intracellular membrane and contains trans-Golgi network protein 2.
    Nagashima S, Takahashi M, Jirintai S, Tanggis, Kobayashi T, Nishizawa T, Okamoto H
    Archives of virology 159 979-991 May 2014
  • The complete genomes of subgenotype IA hepatitis A virus strains from four different islands in Indonesia form a phylogenetic cluster.
    Mulyanto, Wibawa ID, Suparyatmo JB, Amirudin R, Ohnishi H, Takahashi M, Nishizawa T, Okamoto H
    Archives of virology 159 935-945 May 2014
  • Extravillous trophoblast cell invasion is promoted by the CD44-hyaluronic acid interaction.
    Takahashi H, Takizawa T, Matsubara S, Ohkuchi A, Kuwata T, Usui R, Matsumoto H, Sato Y, Fujiwara H, Okamoto A, Suzuki M, Takizawa T
    Placenta 35 163-170 Mar. 2014
  • Molecular characterization of a novel hepatitis E virus (HEV) strain obtained from a wild boar in Japan that is highly divergent from the previously recognized HEV strains.
    Takahashi M, Nishizawa T, Nagashima S, Jirintai S, Kawakami M, Sonoda Y, Suzuki T, Yamamoto S, Shigemoto K, Ashida K, Sato Y, Okamoto H
    Virus research 180 59-69 Feb. 2014
  • Marked genomic heterogeneity of rat hepatitis E virus strains in Indonesia demonstrated on a full-length genome analysis.
    Mulyanto, Suparyatmo JB, Andayani IG, Khalid, Takahashi M, Ohnishi H, Jirintai S, Nagashima S, Nishizawa T, Okamoto H
    Virus research 179 102-112 Jan. 2014
  • Features of hepatitis E virus infection in humans and animals in Japan.
    Takahashi M, Okamoto H
    Hepatology research : the official journal of the Japan Society of Hepatology 44 43-58 Jan. 2014
  • Randomized, open-label, phase III study comparing irinotecan with paclitaxel in patients with advanced gastric cancer without severe peritoneal metastasis after failure of prior combination chemotherapy using fluoropyrimidine plus platinum: WJOG 4007 tria
    Hironaka S, Ueda S, Yasui H, Nishina T, Tsuda M, Tsumura T, Sugimoto N, Shimodaira H, Tokunaga S, Moriwaki T, Esaki T, Nagase M, Fujitani K, Yamaguchi K, Ura T, Hamamoto Y, Morita S, Okamoto I, Boku N, Hyodo I
    Journal of clinical oncology : official journal of the American Society of Clinical Oncology 31 4438-4444 Dec. 2013
  • Drug induced hypersensitivity syndrome by triple therapy of peginterferon alpha2b, ribavirin and telaprevir in patient with double positive for HBV and HCV.
    Takagi H, Hoshino T, Naganuma A, Koitabashi E, Uehara S, Sakamoto N, Kudo T, Ryusaki K, Kakizaki S, Okamoto H
    Hepato-gastroenterology 60 1557-1560 Oct. 2013
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Papers(paper)close
  • Rat hepatitis E virus derived from wild rats (Rattus rattus) propagates efficiently in human hepatoma cell lines.
    Jirintai S, Tanggis, Mulyanto, Suparyatmo JB, Takahashi M, Kobayashi T, Nagashima S, Nishizawa T, Okamoto H
    Virus research 185 92-102 Jun. 2014
  • The origin of HCV genotype 3 in Africa as estimated through an evolutionary analysis of the full-length genomes of nine subtypes, including the newly sequenced 3d and 3e.
    Li C, Lu L, Murphy DG, Negro F, Okamoto H
    The Journal of general virology May 2014
  • The membrane on the surface of hepatitis E virus particles is derived from the intracellular membrane and contains trans-Golgi network protein 2.
    Nagashima S, Takahashi M, Jirintai S, Tanggis, Kobayashi T, Nishizawa T, Okamoto H
    Archives of virology 159 979-991 May 2014
  • The complete genomes of subgenotype IA hepatitis A virus strains from four different islands in Indonesia form a phylogenetic cluster.
    Mulyanto, Wibawa ID, Suparyatmo JB, Amirudin R, Ohnishi H, Takahashi M, Nishizawa T, Okamoto H
    Archives of virology 159 935-945 May 2014
  • Extravillous trophoblast cell invasion is promoted by the CD44-hyaluronic acid interaction.
    Takahashi H, Takizawa T, Matsubara S, Ohkuchi A, Kuwata T, Usui R, Matsumoto H, Sato Y, Fujiwara H, Okamoto A, Suzuki M, Takizawa T
    Placenta 35 163-170 Mar. 2014
  • Molecular characterization of a novel hepatitis E virus (HEV) strain obtained from a wild boar in Japan that is highly divergent from the previously recognized HEV strains.
    Takahashi M, Nishizawa T, Nagashima S, Jirintai S, Kawakami M, Sonoda Y, Suzuki T, Yamamoto S, Shigemoto K, Ashida K, Sato Y, Okamoto H
    Virus research 180 59-69 Feb. 2014
  • Marked genomic heterogeneity of rat hepatitis E virus strains in Indonesia demonstrated on a full-length genome analysis.
    Mulyanto, Suparyatmo JB, Andayani IG, Khalid, Takahashi M, Ohnishi H, Jirintai S, Nagashima S, Nishizawa T, Okamoto H
    Virus research 179 102-112 Jan. 2014
  • Features of hepatitis E virus infection in humans and animals in Japan.
    Takahashi M, Okamoto H
    Hepatology research : the official journal of the Japan Society of Hepatology 44 43-58 Jan. 2014
  • Randomized, open-label, phase III study comparing irinotecan with paclitaxel in patients with advanced gastric cancer without severe peritoneal metastasis after failure of prior combination chemotherapy using fluoropyrimidine plus platinum: WJOG 4007 tria
    Hironaka S, Ueda S, Yasui H, Nishina T, Tsuda M, Tsumura T, Sugimoto N, Shimodaira H, Tokunaga S, Moriwaki T, Esaki T, Nagase M, Fujitani K, Yamaguchi K, Ura T, Hamamoto Y, Morita S, Okamoto I, Boku N, Hyodo I
    Journal of clinical oncology : official journal of the American Society of Clinical Oncology 31 4438-4444 Dec. 2013
  • Drug induced hypersensitivity syndrome by triple therapy of peginterferon alpha2b, ribavirin and telaprevir in patient with double positive for HBV and HCV.
    Takagi H, Hoshino T, Naganuma A, Koitabashi E, Uehara S, Sakamoto N, Kudo T, Ryusaki K, Kakizaki S, Okamoto H
    Hepato-gastroenterology 60 1557-1560 Oct. 2013
  • Characterization of sporadic acute hepatitis E and comparison of hepatitis E virus genomes in acute hepatitis patients and pig liver sold as food in Mie, Japan.
    Okano H, Takahashi M, Isono Y, Tanaka H, Nakano T, Oya Y, Sugimoto K, Ito K, Ohmori S, Maegawa T, Kobayashi M, Nagashima S, Nishizawa T, Okamoto H
    Hepatology research : the official journal of the Japan Society of Hepatology Aug. 2013
  • Identification of European-type hepatitis E virus subtype 3e isolates in Japanese wild boars: molecular tracing of HEV from swine to wild boars.
    Nakano T, Takahashi K, Arai M, Okano H, Kato H, Ayada M, Okamoto H, Mishiro S
    Infection, genetics and evolution : journal of molecular epidemiology and evolutionary genetics in infectious diseases 18 287-298 Aug. 2013
  • Development of a highly sensitive bioluminescent enzyme immunoassay for hepatitis B virus surface antigen capable of detecting divergent mutants.
    Minekawa T, Takehara S, Takahashi M, Okamoto H
    Clinical and vaccine immunology : CVI 20 1255-1265 Aug. 2013
  • Williams-Beuren syndrome with brain malformation and hypertrophic cardiomyopathy.
    Okamoto N, Yamagata T, Yada Y, Ichihashi K, Matsumoto N, Momoi MY, Mizuguchi T
    Brain & development Jul. 2013
  • Analysis of the anatomic subsites, gender and age in unresectable advanced colorectal carcinomas in Tochigi, Japan suggests a shift in location towards the right side colon in elderly patients treated with cetuximab.
    Tanaka T, Ichikawa K, Maruoka T, Tomita S, Ueda H, Yamaguchi T, Shida Y, Kato H, Nagata H, Kubota K, Akimoto N, Sakamoto C, Imura J, Arita M, Tanaka H, Okamoto Y, Igarashi Y, Fujimori T
    Molecular and clinical oncology 1 291-296 Mar. 2013
  • Culture systems for hepatitis E virus.
    Okamoto H
    Journal of gastroenterology 48 147-158 Feb. 2013
  • IgG anti-NR2 glutamate receptor autoantibodies from patients with systemic lupus erythematosus activate endothelial cells.
    Yoshio T, Okamoto H, Hirohata S, Minota S
    Arthritis and rheumatism 65 457-463 Feb. 2013
  • Allogeneic hematopoietic stem cell transplantation for patients with mildly reduced renal function as defined based on creatinine clearance before transplantation.
    Oshima K, Kanda Y, Nanya Y, Tanaka M, Nakaseko C, Yano S, Fujisawa S, Fujita H, Yokota A, Takahashi S, Kanamori H, Okamoto S, Kanto Study Group for Cell Therapy
    Annals of hematology 92 255-260 Jan. 2013
  • Frequent detection and characterization of hepatitis E virus variants in wild rats (Rattus rattus) in Indonesia
    Mulyanto, Depamede S.N, Sriasih M, Takahashi M, Nagashima S, Jirintai S, Nishizawa T, Okamoto H
    Archives of Virology 158(1) 87-96 2013
  • Full genome analysis of Philippine indigenous subgenotype IA hepatitis A virus strains from Japanese patients with imported acute hepatitis A
    Watanabe S, Isoda N, Ohtake T, Hirosawa T, Morimoto N, Aoki K, Ohnishi H, Takahashi M, Sugano K, Okamoto H
    Hepatology Research 2013
  • Full-length genome sequences of five hepatitis C virus isolates representing subtypes 3g, 3h, 3i and 3k, and a unique genotype 3 variant
    Lu L, Li C, Yuan J, Lu T, Okamoto H, Murphy D.G
    Journal of General Virology 94(PART3) 543-548 2013
  • High genomic similarity between European type hepatitis E virus subgenotype 3e strains isolated from an acute hepatitis patient and a wild boar in Mie, Japan
    Okano H, Nakano T, Sugimoto K, Takahashi K, Nagashima S, Takahashi M, Arai M, Okamoto H
    Hepatology Research 2013
  • Clinically-oriented monitoring of acute effects of methylphenidate on cerebral hemodynamics in ADHD children using fNIRS.
    Monden Y, Dan H, Nagashima M, Dan I, Kyutoku Y, Okamoto M, Yamagata T, Momoi MY, Watanabe E
    Clinical neurophysiology : official journal of the International Federation of Clinical Neurophysiology 123 1147-1157 Jun. 2012
  • A549 and PLC/PRF/5 cells can support the efficient propagation of swine and wild boar hepatitis E virus (HEV) strains: demonstration of HEV infectivity of porcine liver sold as food.
    Takahashi H, Tanaka T, Jirintai S, Nagashima S, Takahashi M, Nishizawa T, Mizuo H, Yazaki Y, Okamoto H
    Archives of virology 157(2) 235-246 Feb. 2012
  • A case of hepatitis E differentially diagnosed from drug-induced liver injury
    Ishiwata S, Takagi H, Hoshino T, Naganuma A, Sakamoto N, Koitabashi E, Souma H, Inui M, Kudo T, Ogawa A, Tahara H, Kaneko M, Okamoto H
    Journal of Japanese Society of Gastroenterology 109(4) 624-629 2012
  • A marked decrease in CD4-positive lymphocytes at the onset of hepatitis in a patient with hepatitis-associated aplastic anemia
    Ikeda T, Morimoto A, Nakamura S, Yokoyama K, Hayase T, Oh Y, Kashii Y, Yotsumoto S, Okamoto H, Momoi M.Y
    Journal of Pediatric Hematology/Oncology 34(5) 375-377 2012
  • Icteric acute hepatitis E with no response of immunoglobulin M class anti-hepatitis E virus antibody
    Takikawa Y, Miyamoto Y, Onodera M, Kuroda H, Kasai K, Miyasaka A, Takahashi M, Okamoto H, Suzuki K
    Hepatology Research 42(11) 1146-1149 2012
  • Identification of four novel subgenotypes (C13-C16) and two inter-genotypic recombinants (C12/G and C13/B3) of hepatitis B virus in Papua Province, Indonesia
    Mulyanto, Pancawardani P, Depamede S.N, Wahyono A, Jirintai S, Nagashima S, Takahashi M, Nishizawa T, Okamoto H
    Virus Research 163(1) 129-140 2012
  • Molecular analysis of hepatitis E virus from farm rabbits in Inner Mongolia, China and its successful propagation in A549 and PLC/PRF/5 cells
    Jirintai S, Jinshan, Tanggis, Manglai D, Mulyanto, Takahashi M, Nagashima S, Kobayashi T, Nishizawa T, Okamoto H
    Virus Research 170(1-2) 126-137 2012
  • Molecular epidemiology and genetic history of European-type genotype 3 hepatitis E virus indigenized in the central region of Japan
    Nakano T, Okano H, Kobayashi M, Ito K, Ohmori S, Nomura T, Kato H, Ayada M, Nakano Y, Akachi S, Sugimoto K, Fujita N, Shiraki K, Takei Y, Takahashi M, Okamoto H
    Infection, Genetics and Evolution 12(7) 1524-1534 2012
  • New findings regarding the epidemic history and population dynamics of Japan-indigenous genotype 3 hepatitis E virus inferred by molecular evolution
    Nakano T, Takahashi K, Pybus O.G, Hashimoto N, Kato H, Okano H, Kobayashi M, Fujita N, Shiraki K, Takei Y, Ayada M, Arai M, Okamoto H, Mishiro S
    Liver International 32(4) 675-688 2012
  • Small epidemic of hepatitis E in the fall 2009 in Sapporo, Hokkaido
    Ozeki I, Kang J.-H, Mizuo H, Akaike J, Ohmura T, Karino Y, Matsui T, Saga A, Watanabe M, Miura Y, Kura T, Tsunematsu I, Matsubayashi K, Sakata H, Okamoto H, Takahashi K, Arai M
    Acta Hepatologica Japonica 53(2) 78-89 2012
  • Analysis of the full-length genome of a hepatitis E virus isolate obtained from a wild boar in Japan that is classifiable into a novel genotype.
    Takahashi M, Nishizawa T, Sato H, Sato Y, Jirintai, Nagashima S, Okamoto H
    The Journal of general virology 92 902-908 Apr. 2011
  • [Virological characteristics of hepatitis E virus].
    Okamoto H
    Nihon rinsho. Japanese journal of clinical medicine 69 Suppl 4 579-587 2011
  • A nationwide survey of hepatitis E virus (HEV) infection in wild boars in Japan: Identification of boar HEV strains of genotypes 3 and 4 and unrecognized genotypes
    Sato Y, Sato H, Naka K, Furuya S, Tsukiji H, Kitagawa K, Sonoda Y, Usui T, Sakamoto H, Yoshino S, Shimizu Y, Takahashi M, Nagashima S, Jirintai, Nishizawa T, Okamoto H
    Archives of Virology 156(8) 1345-1358 2011
  • A PSAP motif in the ORF3 protein of hepatitis E virus is necessary for virion release from infected cells
    Nagashima S, Takahashi M, Jirintai, Tanaka T, Yamada K, Nishizawa T, Okamoto H
    Journal of General Virology 92(2) 269-278 2011
  • Analysis of the full length genomes of novel hepatitis B virus subgenotypes C11 and C12 in Papua, Indonesia
    Mulyanto, Depamede S.N, Wahyono A, Jirintai, Nagashima S, Takahashi M, Okamoto H
    Journal of Medical Virology 83(1) 2011
  • Analysis of the full-length genome of a Hepatitis E Virus isolate obtained from a wild boar in Japan that is classifiable into a Novel Genotype
    Takahashi M, Nishizawa T, Sato H, Sato Y, Jirintai, Nagashima S, Okamoto H
    Journal of General Virology 92(4) 902-908 2011
  • Efficient cell culture systems for hepatitis E virus strains in feces and circulating blood
    Okamoto H
    Reviews in Medical Virology 21(1) 18-31 2011
  • Epidemiological survey of hepatitis E virus infection in Kushiro and Nemuro cities in eastern Hokkaido: Relationship between regional difference of HEV prevalence and distinct food cultures
    Tanabe T, Mizuo H, Yazaki Y, Takahashi M, Okamoto H
    Acta Hepatologica Japonica 52(9) 567-574 2011
  • Four cases of sporadic acute hepatitis E in Mie, Japan who were infected with European type genotype 3 hepatitis E virus
    Okano H, Nakano T, Matsusaki S, Sase T, Saitou T, Mukai K, Nishimura A, Ito K, Shiraki K, Takei Y, Okamoto H
    Acta Hepatologica Japonica 52(5) 295-302 2011
  • Hepatitis E virus cell culture models
    Okamoto H
    Virus Research 161(1) 65-77 2011
  • Identification and characterization of a natural inter-genotypic (2b/1b) recombinant hepatitis C virus in Japan
    Yokoyama K, Takahashi M, Nishizawa T, Nagashima S, Jirintai S, Yotsumoto S, Okamoto H, Momoi M.Y
    Archives of Virology 156(9) 1591-1601 2011
  • Tumour susceptibility gene 101 and the vacuolar protein sorting pathway are required for the release of hepatitis E virions
    Nagashima S, Takahashi M, Jirintai S, Tanaka T, Nishizawa T, Yasuda J, Okamoto H
    Journal of General Virology 92(12) 2838-2848 2011
  • One-year low-dose valacyclovir as prophylaxis for varicella zoster virus disease after allogeneic hematopoietic stem cell transplantation. A prospective study of the Japan Hematology and Oncology Clinical Study Group.
    Oshima K, Takahashi T, Mori T, Matsuyama T, Usuki K, Asano-Mori Y, Nakahara F, Okamoto S, Kurokawa M, Kanda Y
    Transplant infectious disease : an official journal of the Transplantation Society 12 421-427 Oct. 2010
  • [Cell culture system for hepatitis E virus].
    Okamoto H
    Uirusu 60 93-104 Jun. 2010
  • [Torque teno virus].
    Okamoto H
    Nihon rinsho. Japanese journal of clinical medicine 68 Suppl 6 465-468 Jun. 2010
  • Hepatitis E Virus (HEV) strains in serum samples can replicate efficiently in cultured cells despite the coexistence of HEV antibodies: characterization of HEV virions in blood circulation.
    Takahashi M, Tanaka T, Takahashi H, Hoshino Y, Nagashima S, Jirintai, Mizuo H, Yazaki Y, Takagi T, Azuma M, Kusano E, Isoda N, Sugano K, Okamoto H
    Journal of clinical microbiology 48 1112-1125 Apr. 2010
  • [Cell culture system for hepatitis E virus].
    Okamoto H
    Uirusu. Journal of virology 60(1) 93-104 2010
  • [Torque teno virus].
    Okamoto H
    Nippon rinsho. Japanese journal of clinical medicine 68 Suppl 6 465-468 2010
  • A case of acute hepatitis C caused by interspousal transmission after 30 years of marriage
    Nishimura N, Isoda N, Higashizawa T, Otake T, Tsukui M, Nagashima S, Takahashi M, Okamoto H, Sugano K
    Clinical Journal of Gastroenterology 3(1) 50-56 2010
  • A case of domestic hepatitis E living in Ibaraki Prefecture who was suspected to contract infection of a new Sapporo HEV strain while traveling in Hokkaido
    Aikawa T, Ikezawa K, Mamiya T, Ueno C, Wada Y, Shimada S, Tsuda F, Takahashi M, Okamoto H
    Acta Hepatologica Japonica 51(10) 579-581 2010
  • A nationwide survey of hepatitis E virus infection in the general population of Japan
    Takahashi M, Tamura K, Hoshino Y, Nagashima S, Yazaki Y, Mizuo H, Iwamoto S, Okayama M, Nakamura Y, Kajii E, Okamoto H
    Journal of Medical Virology 82(2) 271-281 2010
  • Declining hepatitis C virus (HCV) prevalence in pregnant women: Impact of anti-HCV screening of donated blood: TRANSFUSION COMPLICATIONS
    Ohto H, Ishii T, Kitazawa J, Sugiyama S, Ujiie N, Fujimori K, Ariga H, Satoh T, Nollet K.E, Okamoto H, Hoshi T
    Transfusion 50(3) 693-700 2010
  • Hepatitis e virus (HEV) strains in serum samples can replicate efficiently in cultured cells despite the coexistence of HEV antibodies: Characterization of HEV virions in blood circulation
    Takahashi M, Tanaka T, Takahashi H, Hoshino Y, Nagashima S, Jirintai, Mizuo H, Yazaki Y, Takagi T, Azuma M, Kusano E, Isoda N, Sugano K, Okamoto H
    Journal of Clinical Microbiology 48(4) 1112-1125 2010
  • Hepatitis-associated aplastic anemia during a primary infection of genotype 1a torque teno virus
    Ishimura M, Ohga S, Ichiyama M, Kusuhara K, Takada H, Hara T, Takahashi M, Okamoto H
    European Journal of Pediatrics 169(7) 899-902 2010
  • Identification and characterization of novel hepatitis B virus subgenotype C10 in Nusa Tenggara, Indonesia
    Mulyanto, Depamede S.N, Surayah K, Tjahyono A.A.H, Jirintai, Nagashima S, Takahashi M, Okamoto H
    Archives of Virology 155(5) 705-715 2010
  • Molecular and serological survey of hepatitis E virus infection among domestic pigs in Inner Mongolia, China
    Jinshan, Jirintai, Manglai D, Takahashi M, Nagashima S, Okamoto H
    Archives of Virology 155(8) 1217-1226 2010
  • Retrospective comparison of mobilization methods for autologous stem cell transplantation in multiple myeloma.
    Nakasone H, Kanda Y, Ueda T, Matsumoto K, Shimizu N, Minami J, Sakai R, Hagihara M, Yokota A, Oshima K, Tsukada Y, Tachibana T, Nakaseko C, Fujisawa S, Yano S, Fujita H, Takahashi S, Kanamori H, Okamoto S, Kanto Study Group of Cell Therapy
    American journal of hematology 84 809-814 Dec. 2009
  • ORF3 protein of hepatitis E virus is essential for virion release from infected cells.
    Yamada K, Takahashi M, Hoshino Y, Takahashi H, Ichiyama K, Nagashima S, Tanaka T, Okamoto H
    The Journal of general virology 90 1880-1891 Aug. 2009
  • [Recent advances in hepatitis E: including the development and application of a robust cell culture system for HEV].
    Okamoto H
    Nihon Shokakibyo Gakkai zasshi = The Japanese journal of gastro-enterology 106 177-187 Feb. 2009
  • Analysis of the entire genomes of torque teno midi virus variants in chimpanzees: infrequent cross-species infection between humans and chimpanzees.
    Ninomiya M, Takahashi M, Hoshino Y, Ichiyama K, Simmonds P, Okamoto H
    The Journal of general virology 90 347-358 Feb. 2009
  • A first case of pregnant woman who contracted infection of indigenous genotype 3 hepatitis E virus in Japan
    Aikawa T, Yamagata K, Miyamoto K, Tsuda F, Takahashi M, Okamoto H
    Acta Hepatologica Japonica 50(3) 163-165 2009
  • A nationwide molecular epidemiological study on hepatitis B virus in Indonesia: Identification of two novel subgenotypes, B8 and C7
    Mulyanto, Depamede S.N, Surayah K, Tsuda F, Ichiyama K, Takahashi M, Okamoto H
    Archives of Virology 154(7) 1047-1059 2009
  • Analysis of the entire genomes of Torque teno midi virus variants in chimpanzees: Infrequent cross-species infection between humans and chimpanzees
    Ninomiya M, Takahashi M, Hoshino Y, Ichiyama K, Simmonds P, Okamoto H
    Journal of General Virology 90(2) 347-358 2009
  • Construction of an infectious cDNA clone of hepatitis E virus strain JE03-1760F that can propagate efficiently in cultured cells
    Yamada K, Takahashi M, Hoshino Y, Takahashi H, Ichiyama K, Tanaka T, Okamoto H
    Journal of General Virology 90(2) 457-462 2009
  • Determination of the 5′-terminal sequence of subgenomic RNA of hepatitis E virus strains in cultured cells
    Ichiyama K, Yamada K, Tanaka T, Nagashima S, Jirintai, Takahashi M, Okamoto H
    Archives of Virology 154(12) 1945-1951 2009
  • Development and characterization of a genotype 4 hepatitis E virus cell culture system using a HE-JF5/15F strain recovered from a fulminant hepatitis patient
    Tanaka T, Takahashi M, Takahashi H, Ichiyama K, Hoshino Y, Nagashima S, Mizuo H, Okamoto H
    Journal of Clinical Microbiology 47(6) 1906-1910 2009
  • Hepatitis A and E virus infections among children in Mongolia
    Davaalkham D, Enkhoyun T, Takahashi M, Nakamura Y, Okamoto H
    American Journal of Tropical Medicine and Hygiene 81(2) 248-251 2009
  • History of discoveries and pathogenicity of TT viruses
    Okamoto H
    Current Topics in Microbiology and Immunology 331 1-20 2009
  • Molecular analysis of transmission of hepatitis C virus in a nurse who acquired acute hepatitis C after caring for a viremic patient with epistaxis
    Toda T, Mitsui T, Tsukamoto Y, Ebara T, Hirose A, Masuko K, Nagashima S, Takahashi M, Okamoto H
    Journal of Medical Virology 81(8) 1363-1370 2009
  • No evidence for patient-to-patient transmission of hepatitis C Virus during upper gastrointestinal endoscopy: Molecular Studies on three acute hepatitis c patients No evidence for patient-to-patient transmission of hepatitis C Virus during upper gastroint
    Toda T, Mitsui T, Tsukamoto Y, Ebara T, Masuko K, Takahashi M, Okamoto H
    Digestive Endoscopy 21(3) 147-153 2009
  • Nucleotide substitutions of hepatitis E virus genomes associated with fulminant hepatitis and disease severity
    Inoue J, Takahashi M, Mizuo H, Suzuki K, Aikawa T, Shimosegawa T, Okamoto H
    Tohoku Journal of Experimental Medicine 218(4) 279-284 2009
  • Recent advances in hepatitis E: Including the development and application of a robust cell culture system for HEV
    Okamoto H
    Journal of Japanese Society of Gastroenterology 106(2) 177-187 2009
  • Recent advances in hepatitis E: including the development and application of a robust cell culture system for HEV
    Okamoto H
    Nippon Shokakibyo Gakkai zasshi The Japanese journal of gastro-enterology 106(2) 177-187 2009
  • Sporadic acute hepatitis E occurred constantly during the last decade in northeast Japan
    Inoue J, Ueno Y, Nagasaki F, Akahane T, Fukushima K, Kogure T, Kondo Y, Kakazu E, Tamai K, Kido O, Nakagome Y, Ninomiya M, Obara N, Wakui Y, Takahashi M, Okamoto H, Shimosegawa T
    Journal of Gastroenterology 44(4) 329-337 2009
  • TT viruses in animals
    Okamoto H
    Current Topics in Microbiology and Immunology 331 35-52 2009
  • Virulent strain of hepatitis E virus genotype 3, Japan
    Takahashi K, Okamoto H, Abe N, Kawakami M, Matsuda H, Mochida S, Sakugawa H, Suginoshita Y, Watanabe S, Yamamoto K, Miyakawa Y, Mishiro S
    Emerging Infectious Diseases 15(5) 704-709 2009
  • TT viruses in animals.
    Okamoto H
    Current topics in microbiology and immunology 331 35-52 2009
  • History of discoveries and pathogenicity of TT viruses.
    Okamoto H
    Current topics in microbiology and immunology 331 1-20 2009
  • Multicenter prospective trial evaluating the tolerability of imatinib for Japanese patients with chronic myelogenous leukemia in the chronic phase: does body weight matter?
    Kanda Y, Okamoto S, Tauchi T, Kizaki M, Inokuchi K, Yabe M, Yokoyama K, Ito Y, Kimura Y, Higashihara M, Bessho M, Ando K, Chiba S, Kurokawa M, Oshimi K, Dan K, Ohyashiki K, Ikeda Y, Tokyo STI Study Group (TSSG)
    American journal of hematology 83 835-839 Nov. 2008
  • Central nervous system relapse of leukemia after allogeneic hematopoietic stem cell transplantation.
    Oshima K, Kanda Y, Yamashita T, Takahashi S, Mori T, Nakaseko C, Fujimaki K, Yokota A, Fujisawa S, Matsushima T, Fujita H, Sakura T, Okamoto S, Maruta A, Sakamaki H, Kanto Study Group for Cell Therapy
    Biology of blood and marrow transplantation : journal of the American Society for Blood and Marrow Transplantation 14 1100-1107 Oct. 2008
  • A case of acute hepatitis C, most likely by interspousal sexual transmission after 40 years of marriage
    Aikawa T, Kojima M, Miyamoto K, Ueno C, Takahashi M, Okamoto H
    Acta Hepatologica Japonica 49(8) 352-361 2008
  • Analysis of the full-length genome of hepatitis B virus in the serum and cerebrospinal fluid of a patient with acute hepatitis B and transverse myelitis
    Inoue J, Ueno Y, Kogure T, Nagasaki F, Kimura O, Obara N, Kido O, Nakagome Y, Kakazu E, Matsuda Y, Fukushima K, Segawa H, Nakajima I, Itoyama Y, Takahashi M, Okamoto H, Shimosegawa T
    Journal of Clinical Virology 41(4) 301-304 2008
  • Development of PCR assays with nested primers specific for differential detection of three human anelloviruses and early acquisition of dual or triple infection during infancy
    Ninomiya M, Takahashi M, Nishizawa T, Shimosegawa T, Okamoto H
    Journal of Clinical Microbiology 46(2) 507-514 2008
  • Monitoring serum hepatitis C virus (HCV) RNA in patients with HCV-infected CD20-positive B-cell lymphoma undergoing rituximab combination chemotherapy
    Ennishi D, Terui Y, Yokoyama M, Mishima Y, Takahashi S, Takeuchi K, Okamoto H, Tanimoto M, Hatake K
    American Journal of Hematology 83(1) 59-62 2008
  • Monoclonal antibodies raised against the ORF3 protein of hepatitis e virus (HEV) can capture HEV particles in culture supernatant and serum but not those in feces
    Takahashi M, Yamada K, Hoshino Y, Takahashi H, Ichiyama K, Tanaka T, Okamoto H
    Archives of Virology 153(9) 1703-1713 2008
  • Mutational events during the primary propagation and consecutive passages of hepatitis E virus strain JE03-1760F in cell culture
    Lorenzo F.R, Tanaka T, Takahashi H, Ichiyama K, Hoshino Y, Yamada K, Inoue J, Takahashi M, Okamoto H
    Virus Research 137(1) 86-96 2008
  • Production of monoclonal antibodies against hepatitis E virus capsid protein and evaluation of their neutralizing activity in a cell culture system
    Takahashi M, Hoshino Y, Tanaka T, Takahashi H, Nishizawa T, Okamoto H
    Archives of Virology 153(4) 657-666 2008
  • Torque teno virus DNA titre elevated in idiopathic pulmonary fibrosis with primary lung cancer
    Bando M, Takahashi M, Ohno S, Hosono T, Hironaka M, Okamoto H, Sugiyama Y
    Respirology 13(2) 263-269 2008
  • Monoclonal antibodies raised against the ORF3 protein of hepatitis E virus (HEV) can capture HEV particles in culture supernatant and serum but not those in feces.
    Takahashi M, Yamada K, Hoshino Y, Takahashi H, Ichiyama K, Tanaka T, Okamoto H
    Archives of virology 153 1703-1713 2008
  • Prolonged fecal shedding of hepatitis E virus (HEV) during sporadic acute hepatitis E: evaluation of infectivity of HEV in fecal specimens in a cell culture system.
    Takahashi M, Tanaka T, Azuma M, Kusano E, Aikawa T, Shibayama T, Yazaki Y, Mizuo H, Inoue J, Okamoto H
    Journal of clinical microbiology 45 3671-3679 Nov. 2007
  • Prevalence of hepatitis B, C, and delta virus infections among children in Mongolia: progress in childhood immunization.
    Tsatsralt-Od B, Takahashi M, Endo K, Agiimaa D, Buyankhuu O, Ninomiya M, Lorenzo FR, Okamoto H
    Journal of medical virology 79 1064-1074 Aug. 2007
  • Full-length sequences of subgenotype IIIA and IIIB hepatitis A virus isolates: characterization of genotype III HAV genomes.
    Endo K, Takahashi M, Masuko K, Inoue K, Akahane Y, Okamoto H
    Virus research 126 116-127 Jun. 2007
  • Retrospective nationwide survey of Japanese patients with transfusion-dependent MDS and aplastic anemia highlights the negative impact of iron overload on morbidity/mortality.
    Takatoku M, Uchiyama T, Okamoto S, Kanakura Y, Sawada K, Tomonaga M, Nakao S, Nakahata T, Harada M, Murate T, Ozawa K, Japanese National Research Group on Idiopathic Bone Marrow Failure Syndromes
    European journal of haematology 78 487-494 Jun. 2007
  • Comparison of hepatitis A and E virus infections among healthy children in Mongolia: evidence for infection with a subgenotype IA HAV in children.
    Tsatsralt-Od B, Takahashi M, Endo K, Agiimaa D, Buyankhuu O, Okamoto H
    Journal of medical virology 79 18-25 Jan. 2007
  • Analysis of the full-length genome of a subgenotype IIIB hepatitis A virus isolate: primers for broadly reactive PCR and genotypic analysis.
    Endo K, Inoue J, Takahashi M, Mitsui T, Masuko K, Akahane Y, Okamoto H
    Journal of medical virology 79 8-17 Jan. 2007
  • A case of acute hepatitis E associated with multidrug hypersensitivity and cytomegalovirus reactivation
    Takikawa Y, Yasumi Y, Sato A, Endo R, Suzuki K, Mori Y, Akasaka H, Miura Y, Sawai T, Okamoto H
    Hepatology Research 37(2) 158-165 2007
  • A case of imported hepatitis E: Identification of location of HEV infection by the molecular epidemiological approach
    Aikawa T, Miyamoto K, Ueno C, Kojima M, Takahashi M, Tsuda F, Okamoto H
    Acta Hepatologica Japonica 48(1) 15-21 2007
  • A male patient with severe acute hepatitis who was domestically infected with a genotype H hepatitis B virus in Iwate, Japan
    Kumagai I, Abe K, Oikawa T, Sato A, Sato S, Endo R, Takikawa Y, Suzuki K, Masuda T, Sainokami S, Endo K, Takahashi M, Okamoto H
    Journal of Gastroenterology 42(2) 168-175 2007
  • Analysis of hepatitis B surface antigen mutations in Mongolia: Molecular epidemiology and implications for mass vaccination
    Davaalkham D, Ojima T, Uehara R, Watanabe M, Oki I, Endo K, Takahashi M, Okamoto H, Nakamura Y
    Archives of Virology 152(3) 575-584 2007
  • Analysis of the entire genomes of fifteen torque teno midi virus variants classifiable into a third group of genus Anellovirus
    Ninomiya M, Takahashi M, Shimosegawa T, Okamoto H
    Archives of Virology 152(11) 1961-1975 2007
  • Analysis of the full-length genome of a subgenotype IIIB hepatitis A virus isolate: Primers for broadly reactive PCR and genotypic analysis
    Endo K, Inoue J, Takahashi M, Mitsui T, Masuko K, Akahane Y, Okamoto H
    Journal of Medical Virology 79(1) 8-17 2007
  • Analysis of the full-length genome of hepatitis E virus isolates obtained from farm pigs in Mongolia
    Lorenzo F.R, Tsatsralt-Od B, Ganbat S, Takahashi M, Okamoto H
    Journal of Medical Virology 79(8) 1128-1137 2007
  • Comparison of hepatitis A and E virus infections among healthy children in Mongolia: Evidence for infection with a subgenotype IA HAV in children
    Tsatsralt-Od B, Takahashi M, Endo K, Agiimaa D, Buyankhuu O, Okamoto H
    Journal of Medical Virology 79(1) 18-25 2007
  • Complete genomes for hepatitis C virus subtypes 6f, 6i, 6j and 6m: Viral genetic diversity among Thai blood donors and infected spouses
    Lu L, Li C, Fu Y, Thaikruea L, Thongswat S, Maneekarn N, Apichartpiyakul C, Hotta H, Okamoto H, Netski D, Pybus O.G, Murphy D, Hagedorn C.H, Nelson K.E
    Journal of General Virology 88(5) 1505-1518 2007
  • Complete genomes of hepatitis C virus (HCV) subtypes 6c, 6l, 6o, 6p and 6q: Completion of a full panel of genomes for HCV genotype 6
    Lu L, Li C, Fu Y, Gao F, Pybus O.G, Abe K, Okamoto H, Hagedorn C.H, Murphy D
    Journal of General Virology 88(5) 1519-1525 2007
  • Development and evaluation of an efficient cell-culture system for Hepatitis E virus
    Tanaka T, Takahashi M, Kusano E, Okamoto H
    Journal of General Virology 88(3) 903-911 2007
  • Full-length sequences of subgenotype IIIA and IIIB hepatitis A virus isolates: Characterization of genotype III HAV genomes
    Endo K, Takahashi M, Masuko K, Inoue K, Akahane Y, Okamoto H
    Virus Research 126(1-2) 116-127 2007
  • Genetic variability and evolution of hepatitis E virus
    Okamoto H
    Virus Research 127(2) 216-228 2007
  • High prevalence of hepatitis B virus infection and inferior vena cava obstruction among patients with liver cirrhosis or hepatocellular carcinoma in Nepal
    Shrestha S.M, Shrestha S, Shrestha A, Tsuda F, Endo K, Takahashi M, Okamoto H
    Journal of Gastroenterology and Hepatology 22(11) 1921-1928 2007
  • Identification and genomic characterization of a novel human torque teno virus of 3.2 kb
    Ninomiya M, Nishizawa T, Takahashi M, Lorenzo F.R, Shimosegawa T, Okamoto H
    Journal of General Virology 88(7) 1939-1944 2007
  • Identification of genotype 4 hepatitis E virus strains from a patient with acute hepatitis E and farm pigs in Bali, Indonesia
    Wibawa I.D.N, Suryadarma I.G.A, Mulyanto, Tsuda F, Matsumoto Y, Ninomiya M, Takahashi M, Okamoto H
    Journal of Medical Virology 79(8) 1138-1146 2007
  • Initial load of hepatitis B virus (HBV), its changing profile, and precore/core promoter mutations correlate with the severity and outcome of acute HBV infection
    Sainokami S, Abe K, Sato A, Endo R, Takikawa Y, Suzuki K, Okamoto H
    Journal of Gastroenterology 42(3) 241-249 2007
  • Ongoing subclinical infection of hepatitis E virus among blood donors with an elevated alanine aminotransferase level in Japan
    Gotanda Y, Iwata A, Ohnuma H, Yoshikawa A, Mizoguchi H, Endo K, Takahashi M, Okamoto H
    Journal of Medical Virology 79(6) 734-742 2007
  • Prevalence of hepatitis B, C, and delta virus infections among children in Mongolia: Progress in childhood immunization
    Tsatsralt-Od B, Takahashi M, Endo K, Agiimaa D, Buyankhuu O, Ninomiya M, Lorenzo F.R, Okamoto H
    Journal of Medical Virology 79(8) 1064-1074 2007
  • Prolonged fecal shedding of hepatitis E virus (HEV) during sporadic acute hepatitis E: Evaluation of infectivity of HEV in fecal specimens in a cell culture system
    Takahashi M, Tanaka T, Azuma M, Kusano E, Aikawa T, Shibayama T, Yazaki Y, Mizuo H, Inoue J, Okamoto H
    Journal of Clinical Microbiology 45(11) 3671-3679 2007
  • Unchanged high prevalence of antibodies to hepatitis E virus (HEV) and HEV RNA among blood donors with an elevated alanine aminotransferase level in Japan during 1991-2006
    Fukuda S, Ishikawa M, Ochiai N, Suzuki Y, Sunaga J, Shinohara N, Nozawa K, Tsuda F, Takahashi M, Okamoto H
    Archives of Virology 152(9) 1623-1635 2007
  • Analysis of hepatitis B surface antigen mutations in Mongolia: molecular epidemiology and implications for mass vaccination.
    Davaalkham D, Ojima T, Uehara R, Watanabe M, Oki I, Endo K, Takahashi M, Okamoto H, Nakamura Y
    Archives of virology 152 575-584 2007
  • Hepatitis delta virus infection in mongolia: analyses of geographic distribution, risk factors, and disease severity.
    Davaalkham D, Ojima T, Uehara R, Watanabe M, Oki I, Nymadawa P, Takahashi M, Okamoto H, Nakamura Y
    The American journal of tropical medicine and hygiene 75 365-369 Aug. 2006
  • Mouse monoclonal anti-human thrombomodulin antibodies bind to and activate endothelial cells through NF-kappaB activation in vitro.
    Nara H, Okamoto H, Minota S, Yoshio T
    Arthritis and rheumatism 54 1629-1637 May 2006
  • Analysis of human and swine hepatitis E virus (HEV) isolates of genotype 3 in Japan that are only 81-83 % similar to reported HEV isolates of the same genotype over the entire genome
    Inoue J, Takahashi M, Ito K, Shimosegawa T, Okamoto H
    Journal of General Virology 87(8) 2363-2369 2006
  • Analysis of the full-length genome of genotype 4 hepatitis E virus isolates from patients with fulminant or acute self-limited hepatitis E
    Inoue J, Nishizawa T, Takahashi M, Aikawa T, Mizuo H, Suzuki K, Shimosegawa T, Okamoto H
    Journal of Medical Virology 78(4) 476-484 2006
  • Current status of hepatitis E in Japan
    Okamoto H
    Acta Hepatologica Japonica 47(8) 379-383 2006
  • Development and validation of an improved RT-PCR assay with nested universal primers for detection of hepatitis E virus strains with significant sequence divergence
    Inoue J, Takahashi M, Yazaki Y, Tsuda F, Okamoto H
    Journal of Virological Methods 137(2) 325-333 2006
  • Distinct changing profiles of hepatitis A and E virus infection among patients with acute hepatitis, patients on maintenance hemodialysis and healthy individuals in Japan
    Mitsui T, Tsukamoto Y, Hirose A, Suzuki S, Yamazaki C, Masuko K, Tsuda F, Endo K, Takahashi M, Okamoto H
    Journal of Medical Virology 78(8) 1015-1024 2006
  • Four cases of hepatitis E after eating wild boar meats in Aichi, Japan
    Shimizu Y, Yamada M, Tatematsu H, Ishihara M, Morita K, Ishiguro Y, Katano Y, Goto H, Takahashi M, Okamoto H
    Acta Hepatologica Japonica 47(10) 465-473 2006
  • Hepatitis delta virus infection in mongolia: Analyses of geographic distribution, risk factors, and disease severity
    Davaalkham D, Ojima T, Uehara R, Watanabe M, Izumi O, Nymadawa P, Takahashi M, Okamoto H, Nakamura Y
    American Journal of Tropical Medicine and Hygiene 75(2) 365-369 2006
  • Hepatitis E
    Okamoto H
    Nihon Naika Gakkai zasshi. The Journal of the Japanese Society of Internal Medicine 95(5) 945-951 2006
  • Infection with hepatitis A, B, C, and delta viruses among patients with acute hepatitis in Mongolia
    Tsatsralt-Od B, Takahashi M, Endo K, Buyankhuu O, Baatarkhuu O, Nishizawa T, Okamoto H
    Journal of Medical Virology 78(5) 542-550 2006
  • Possible association of vigorous hepatitis B virus replication with the development of fulminant hepatitis
    Inoue K, Ogawa O, Yamada M, Watanabe T, Okamoto H, Yoshiba M
    Journal of Gastroenterology 41(4) 383-387 2006
  • Structural visualization of highly-specialized practice on nursing and midwifery: Nurse-midwife's monitoring and caring during labor and delivery.
    Narita S, Murakami M, Ohara R, Okamoto M, Dannoue H, Tsuru S
    Studies in health technology and informatics 122 936-937 2006
  • Effusive--constrictive epicarditis that developed more than 5 years after ventricular septal defect closure: two cases relieved by epicardiectomy.
    Okamoto N, Shiraishi H, Konishi H, Momoi MY
    Pediatric cardiology 26 872-876 Nov. 2005
  • Simultaneous detection of immunoglobulin A (IgA) and IgM antibodies against hepatitis E virus (HEV) Is highly specific for diagnosis of acute HEV infection.
    Takahashi M, Kusakai S, Mizuo H, Suzuki K, Fujimura K, Masuko K, Sugai Y, Aikawa T, Nishizawa T, Okamoto H
    Journal of clinical microbiology 43 49-56 Jan. 2005
  • A case of acute hepatitis with positive autoantibodies who actually had hepatitis E virus infection
    Nagasaki F, Ueno Y, Kanno N, Okamoto H, Shimosegawa T
    Hepatology Research 32(2) 134-137 2005
  • A patient with clinical features of acute hepatitis E viral infection and autoimmune hepatitis
    Nagasaki F, Ueno Y, Mano Y, Igarashi T, Yahagi K, Niitsuma H, Okamoto H, Shimosegawa T
    Tohoku Journal of Experimental Medicine 206(2) 173-179 2005
  • Analysis of the full-length genome of hepatitis E virus isolates obtained from wild boars in Japan
    Nishizawa T, Takahashi M, Endo K, Fujiwara S, Sakuma N, Kawazuma F, Sakamoto H, Sato Y, Bando M, Okamoto H
    Journal of General Virology 86(12) 3321-3326 2005
  • Characterization of genotype H hepatitis B virus strain identified for the first time from a Japanese blood donor by nucleic acid amplification test
    Ohnuma H, Yoshikawa A, Mizoguchi H, Okamoto H
    Journal of General Virology 86(3) 595-599 2005
  • Characterization of seven genotypes (A to E, G and H) of hepatitis B virus recovered from Japanese patients infected with human immunodeficiency virus type 1
    Shibayama T, Masuda G, Ajisawa A, Hiruma K, Tsuda F, Nishizawa T, Takahashi M, Okamoto H
    Journal of Medical Virology 76(1) 24-32 2005
  • Comparison of the prevalence of hepatitis A and E virus infections among patients infected with human immunodeficiency virus type 1 in Japan
    Shibayama T, Masuda G, Ajisawa A, Gotanda Y, Yoshikawa A, Mizoguchi H, Okamoto H, Tsuda F
    Acta Hepatologica Japonica 46(11) 663-664 2005
  • Consensus proposals for a unified system of nomenclature of hepatitis C virus genotypes
    Simmonds P, Bukh J, Combet C, Deléage G, Enomoto N, Feinstone S, Halfon P, Inchauspé G, Kuiken C, Maertens G, Mizokami M, Murphy D.G, Okamoto H, Pawlotsky J.-M, Penin F, Sablon E, Shin-I T, Stuyver L.J, Thiel H.-J, Viazov S, Weiner A.J, Widell A
    Hepatology 42(4) 962-973 2005
  • Correlation between positivity for immunoglobulin A antibodies and viraemia of swine hepatitis E virus observed among farm pigs in Japan
    Takahashi M, Nishizawa T, Tanaka T, Tsatsralt-Od B, Inoue J, Okamoto H
    Journal of General Virology 86(6) 1807-1813 2005
  • Evolution in the hypervariable region of the hepatitis C virus in two infants infected by mother-to-infant transmission
    Ishii T, Ohto H, Takeuchi C, Ariga H, Hirai S, Ujiie N, Suzuki H, Okamoto H
    Pediatrics International 47(3) 278-285 2005
  • High prevalence of dual or triple infection of hepatitis B, C, and delta viruses among patients with chronic liver disease in Mongolia
    Tsatsralt-Od B, Takahashi M, Nishizawa T, Endo K, Inoue J, Okamoto H
    Journal of Medical Virology 77(4) 491-499 2005
  • High prevalence of hepatitis B, C and delta virus infections among blood donors in Mongolia
    Tsatsralt-Od B, Takahashi M, Nishizawa T, Inoue J, Ulaankhuu D, Okamoto H
    Archives of Virology 150(12) 2513-2528 2005
  • High prevalence of hepatitis delta virus infection detectable by enzyme immunoassay among apparently healthy individuals in Mongolia
    Inoue J, Takahashi M, Nishizawa T, Narantuya L, Sakuma M, Kagawa Y, Shimosegawa T, Okamoto H
    Journal of Medical Virology 76(3) 333-340 2005
  • Molecular investigation of interspousal transmission of hepatitis C virus in two Japanese patients who acquired acute hepatitis C after 40 or 42 years of marriage
    Nakayama H, Sugai Y, Ikeya S, Inoue J, Nishizawa T, Okamoto H
    Journal of Medical Virology 75(2) 258-266 2005
  • Possible risk factors for the transmission of hepatitis E virus and for the severe form of hepatitis E acquired locally in Hokkaido, Japan
    Mizuo H, Yazaki Y, Sugawara K, Tsuda F, Takahashi M, Nishizawa T, Okamoto H
    Journal of Medical Virology 76(3) 341-349 2005
  • Risk factors for the development of hepatocellular carcinoma among patients with chronic hepatitis C who achieved a sustained virological response to interferon therapy
    Tokita H, Fukui H, Tanaka A, Kamitsukasa H, Yagura M, Harada H, Okamoto H
    Journal of Gastroenterology and Hepatology 20(5) 752-758 2005
  • Serological and molecular studies on subclinical hepatitis E virus infection using periodic serum samples obtained from healthy individuals
    Mitsui T, Tsukamoto Y, Suzuki S, Yamazaki C, Masuko K, Tsuda F, Takahashi M, Tsatsralt-Od B, Nishizawa T, Okamoto H
    Journal of Medical Virology 76(4) 526-533 2005
  • Simultaneous detection of immunoglobulin A (IgA) and IgM antibodies against hepatitis E virus (HEV) is highly specific for diagnosis of acute HEV infection
    Takahashi M, Kusakai S, Mizuo H, Suzuki K, Fujimura K, Masuko K, Sugai Y, Aikawa T, Nishizawa T, Okamoto H
    Journal of Clinical Microbiology 43(1) 49-56 2005
  • Clinical significance of virtual colonoscopy (CT colonography) with special reference to polyp morphology.
    Kawamura YJ, Sasaki J, Okamaoto H, Okamoto S, Kobayashi Y, Tanaka O, Konishi F
    Hepato-gastroenterology 51 1686-1688 Nov. 2004
  • [Molecular biology of TTV].
    Okamoto H
    Nihon rinsho. Japanese journal of clinical medicine 62 Suppl 8 557-565 Aug. 2004
  • [Hepatitis E as a zoonosis].
    Okamoto H
    Nihon rinsho. Japanese journal of clinical medicine 62 Suppl 8 524-531 Aug. 2004
  • [Anti-HBs escape mutants--implication of neutralization escape and diagnostic escape].
    Okamoto H
    Nihon rinsho. Japanese journal of clinical medicine 62 Suppl 8 98-105 Aug. 2004
  • Infection of a Japanese patient by genotype 4 hepatitis e virus while traveling in Vietnam.
    Koizumi Y, Isoda N, Sato Y, Iwaki T, Ono K, Ido K, Sugano K, Takahashi M, Nishizawa T, Okamoto H
    Journal of clinical microbiology 42 3883-3885 Aug. 2004
  • High prevalence of antibodies to hepatitis A and E viruses and viremia of hepatitis B, C, and D viruses among apparently healthy populations in Mongolia.
    Takahashi M, Nishizawa T, Gotanda Y, Tsuda F, Komatsu F, Kawabata T, Hasegawa K, Altankhuu M, Chimedregzen U, Narantuya L, Hoshino H, Hino K, Kagawa Y, Okamoto H
    Clinical and diagnostic laboratory immunology 11 392-398 Mar. 2004
  • Anti-HBs escape mutants--implication of neutralization escape and diagnostic escape
    Okamoto H
    Nippon rinsho. Japanese journal of clinical medicine 62 Suppl 8(Pt 2) 98-105 2004
  • Epidemiological and clinical study of sporadic acute hepatitis E caused by indigenous strains of hepatitis E virus in Japan compared with acute hepatitis A
    Sainokami S, Abe K, Kumagai I, Miyasaka A, Endo R, Takikawa Y, Suzuki K, Mizuo H, Sugai Y, Akahane Y, Koizumi Y, Yajima Y, Okamoto H
    Journal of Gastroenterology 39(7) 640-648 2004
  • Genetic changes in hepatitis E virus of subtype 1a in patients with sporadic acute hepatitis E in Kathmandu, Nepal, from 1997 to 2002
    Shrestha S.M, Shrestha S, Tsuda F, Nishizawa T, Takahashi M, Gotanda Y, Okamoto H
    Journal of General Virology 85(1) 97-104 2004
  • Genotyping of hepatitis C virus based on the full genome sequence
    Tokita H, Okamoto H
    Nippon rinsho. Japanese journal of clinical medicine 62 Suppl 7(Pt 1) 70-75 2004
  • Hepatitis E as a zoonosis
    Okamoto H
    Nippon rinsho. Japanese journal of clinical medicine 62 Suppl 8 524-531 2004
  • High Prevalence of Antibodies to Hepatitis A and E Viruses and Viremia of Hepatitis B, C, and D Viruses among Apparently Healthy Populations in Mongolia
    Takahashi M, Nishizawa T, Gotanda Y, Tsuda F, Komatsu F, Kawabata T, Hasegawa K, Altankhuu M, Chimedregzen U, Narantuya L, Hoshino H, Hino K, Kagawa Y, Okamoto H
    Clinical and Diagnostic Laboratory Immunology 11(2) 392-398 2004
  • Infection of a Japanese patient by genotype 4 hepatitis E virus while traveling in Vietnam
    Koizumi Y, Isoda N, Sato Y, Iwaki T, Ono K, Ido K, Sugano K, Takahashi M, Nishizawa T, Okamoto H
    Journal of Clinical Microbiology 42(8) 3883-3885 2004
  • Molecular biology of TTV
    Okamoto H
    Nippon rinsho. Japanese journal of clinical medicine 62 Suppl 8 557-565 2004
  • Molecular investigation of hepatitis E virus infection in domestic and miniature pigs used for medical experiments
    Tanaka H, Yoshino H, Kobayashi E, Takahashi M, Okamoto H
    Xenotransplantation 11(6) 503-510 2004
  • Features of hepatitis E virus infection in Japan.
    Okamoto H, Takahashi M, Nishizawa T
    Internal medicine (Tokyo, Japan) 42 1065-1071 Nov. 2003
  • DNA immunization of the grafted liver by particle-mediated gene gun.
    Nakamura M, Wang J, Murakami T, Ajiki T, Hakamata Y, Kaneko T, Takahashi M, Okamoto H, Mayumi M, Kobayashi E
    Transplantation 76 1369-1375 Nov. 2003
  • Sporadic acute hepatitis E of a 47-year-old man whose pet cat was positive for antibody to hepatitis E virus.
    Kuno A, Ido K, Isoda N, Satoh Y, Ono K, Satoh S, Inamori H, Sugano K, Kanai N, Nishizawa T, Okamoto H
    Hepatology research : the official journal of the Japan Society of Hepatology 26 237-242 Jul. 2003
  • Characterization of Japanese swine and human hepatitis E virus isolates of genotype IV with 99 % identity over the entire genome.
    Nishizawa T, Takahashi M, Mizuo H, Miyajima H, Gotanda Y, Okamoto H
    The Journal of general virology 84 1245-1251 May 2003
  • Swine hepatitis E virus strains in Japan form four phylogenetic clusters comparable with those of Japanese isolates of human hepatitis E virus.
    Takahashi M, Nishizawa T, Miyajima H, Gotanda Y, Iita T, Tsuda F, Okamoto H
    The Journal of general virology 84 851-862 Apr. 2003
  • Autogenous vein graft from iliac artery to splenic artery for celiac occlusion in pancreaticoduodenectomy.
    Okamoto H, Suminaga Y, Toyama N, Konishi F, Kawahito H
    Journal of hepato-biliary-pancreatic surgery 10 109-112 2003
  • Identification of two distinct genotypes of hepatitis E virus in a Japanese patient with acute hepatitis who had not travelled abroad.
    Takahashi M, Nishizawa T, Yoshikawa A, Sato S, Isoda N, Ido K, Sugano K, Okamoto H
    The Journal of general virology 83 1931-1940 Aug. 2002
  • Genomic characterization of TT viruses (TTVs) in pigs, cats and dogs and their relatedness with species-specific TTVs in primates and tupaias.
    Okamoto H, Takahashi M, Nishizawa T, Tawara A, Fukai K, Muramatsu U, Naito Y, Yoshikawa A
    The Journal of general virology 83 1291-1297 Jun. 2002
  • Microsatellite instability as a marker in predicting metachronous multiple colorectal carcinomas after surgery: a cohort-like study.
    Shitoh K, Konishi F, Miyakura Y, Togashi K, Okamoto T, Nagai H
    Diseases of the colon and rectum 45 329-333 Mar. 2002
  • TT virus is distributed in various leukocyte subpopulations at distinct levels, with the highest viral load in granulocytes.
    Takahashi M, Asabe S, Gotanda Y, Kishimoto J, Tsuda F, Okamoto H
    Biochemical and biophysical research communications 290 242-248 Jan. 2002
  • Analysis of the entire genomes of thirteen TT virus variants classifiable into the fourth and fifth genetic groups, isolated from viremic infants.
    Peng YH, Nishizawa T, Takahashi M, Ishikawa T, Yoshikawa A, Okamoto H
    Archives of virology 147 21-41 2002
  • Infection of TT virus in patients with idiopathic pulmonary fibrosis.
    Bando M, Ohno S, Oshikawa K, Takahashi M, Okamoto H, Sugiyama Y
    Respiratory medicine 95 935-942 Dec. 2001
  • Analysis of the complete genome of indigenous swine hepatitis E virus isolated in Japan.
    Okamoto H, Takahashi M, Nishizawa T, Fukai K, Muramatsu U, Yoshikawa A
    Biochemical and biophysical research communications 289 929-936 Dec. 2001
  • Heterogeneous distribution of TT virus of distinct genotypes in multiple tissues from infected humans.
    Okamoto H, Nishizawa T, Takahashi M, Asabe S, Tsuda F, Yoshikawa A
    Virology 288 358-368 Sep. 2001
  • Genomic and evolutionary characterization of TT virus (TTV) in tupaias and comparison with species-specific TTVs in humans and non-human primates.
    Okamoto H, Nishizawa T, Takahashi M, Tawara A, Peng Y, Kishimoto J, Wang Y
    The Journal of general virology 82 2041-2050 Sep. 2001
  • TT virus: virological and genomic characteristics and disease associations.
    Okamoto H, Mayumi M
    Journal of gastroenterology 36 519-529 Aug. 2001
  • Phosphorylation of serine-rich protein encoded by open reading frame 3 of the TT virus genome.
    Asabe S, Nishizawa T, Iwanari H, Okamoto H
    Biochemical and biophysical research communications 286 298-304 Aug. 2001
  • [Molecular virology of TT virus (TTV)].
    Okamoto H, Mayumi M
    Uirusu 50 259-271 Dec. 2000
  • TT virus mRNAs detected in the bone marrow cells from an infected individual.
    Okamoto H, Nishizawa T, Tawara A, Takahashi M, Kishimoto J, Sai T, Sugai Y
    Biochemical and biophysical research communications 279 700-707 Dec. 2000
  • Species-specific TT viruses in humans and nonhuman primates and their phylogenetic relatedness.
    Okamoto H, Nishizawa T, Tawara A, Peng Y, Takahashi M, Kishimoto J, Tanaka T, Miyakawa Y, Mayumi M
    Virology 277 368-378 Nov. 2000
  • Sequestration of TT virus of restricted genotypes in peripheral blood mononuclear cells.
    Okamoto H, Takahashi M, Kato N, Fukuda M, Tawara A, Fukuda S, Tanaka T, Miyakawa Y, Mayumi M
    Journal of virology 74 10236-10239 Nov. 2000
  • Circular double-stranded forms of TT virus DNA in the liver.
    Okamoto H, Ukita M, Nishizawa T, Kishimoto J, Hoshi Y, Mizuo H, Tanaka T, Miyakawa Y, Mayumi M
    Journal of virology 74 5161-5167 Jun. 2000
  • Replicative forms of TT virus DNA in bone marrow cells.
    Okamoto H, Takahashi M, Nishizawa T, Tawara A, Sugai Y, Sai T, Tanaka T, Tsuda F
    Biochemical and biophysical research communications 270 657-662 Apr. 2000
  • Species-specific TT viruses and cross-species infection in nonhuman primates.
    Okamoto H, Fukuda M, Tawara A, Nishizawa T, Itoh Y, Hayasaka I, Tsuda F, Tanaka T, Miyakawa Y, Mayumi M
    Journal of virology 74 1132-1139 Feb. 2000
  • The entire nucleotide sequences of two distinct TT virus (TTV) isolates (TJN01 and TJN02) remotely related to the original TTV isolates.
    Ukita M, Okamoto H, Nishizawa T, Tawara A, Takahashi M, Iizuka H, Miyakawa Y, Mayumi M
    Archives of virology 145 1543-1559 2000
  • Quasispecies of TT virus (TTV) with sequence divergence in hypervariable regions of the capsid protein in chronic TTV infection.
    Nishizawa T, Okamoto H, Tsuda F, Aikawa T, Sugai Y, Konishi K, Akahane Y, Ukita M, Tanaka T, Miyakawa Y, Mayumi M
    Journal of virology 73 9604-9608 Nov. 1999
  • The entire nucleotide sequence of a TT virus isolate from the United States (TUS01): comparison with reported isolates and phylogenetic analysis.
    Okamoto H, Nishizawa T, Ukita M, Takahashi M, Fukuda M, Iizuka H, Miyakawa Y, Mayumi M
    Virology 259 437-448 Jul. 1999
  • Marked genomic heterogeneity and frequent mixed infection of TT virus demonstrated by PCR with primers from coding and noncoding regions.
    Okamoto H, Takahashi M, Nishizawa T, Ukita M, Fukuda M, Tsuda F, Miyakawa Y, Mayumi M
    Virology 259 428-436 Jul. 1999
  • [Molecular virology of TT virus].
    Okamoto H
    Nihon rinsho. Japanese journal of clinical medicine 57 1239-1249 Jun. 1999
  • Excretion into bile of a novel unenveloped DNA virus (TT virus) associated with acute and chronic non-A-G hepatitis.
    Ukita M, Okamoto H, Kato N, Miyakawa Y, Mayumi M
    The Journal of infectious diseases 179 1245-1248 May 1999
  • The significance of microsatellite instability in predicting the development of metachronous multiple colorectal carcinomas in patients with nonfamilial colorectal carcinoma.
    Masubuchi S, Konishi F, Togashi K, Okamoto T, Senba S, Shitoh K, Kashiwagi H, Kanazawa K, Tsukamoto T
    Cancer 85 1917-1924 May 1999
  • Distinct genotypes of a nonenveloped DNA virus associated with posttransfusion non-A to G hepatitis (TT virus) in plasma and peripheral blood mononuclear cells.
    Okamoto H, Kato N, Iizuka H, Tsuda F, Miyakawa Y, Mayumi M
    Journal of medical virology 57 252-258 Mar. 1999
  • A novel unenveloped DNA virus (TT virus) associated with acute and chronic non-A to G hepatitis.
    Okamoto H, Nishizawa T, Ukita M
    Intervirology 42 196-204 1999
  • Significance of microsatellite instability in different types of early-stage nonfamilial colorectal carcinomas.
    Okamoto T, Konishi F, Kojima M, Senba S, Kanazawa K, Tsukamoto T
    Diseases of the colon and rectum 41 1385-1391 Nov. 1998
  • Prevalence of anti-hepatitis C antibodies in a rural community without high mortality from liver disease in Niigata prefecture.
    Kayaba K, Igarashi M, Okamoto H, Tsuda F
    Journal of epidemiology / Japan Epidemiological Association 8 250-255 Oct. 1998
  • Fecal excretion of a nonenveloped DNA virus (TTV) associated with posttransfusion non-A-G hepatitis.
    Okamoto H, Akahane Y, Ukita M, Fukuda M, Tsuda F, Miyakawa Y, Mayumi M
    Journal of medical virology 56 128-132 Oct. 1998
  • The entire nucleotide sequences of three hepatitis C virus isolates in genetic groups 7-9 and comparison with those in the other eight genetic groups.
    Tokita H, Okamoto H, Iizuka H, Kishimoto J, Tsuda F, Miyakawa Y, Mayumi M
    The Journal of general virology 79 ( Pt 8) 1847-1857 Aug. 1998
  • Clinicopathologic and genetic features of nonfamilial colorectal carcinomas with DNA replication errors.
    Senba S, Konishi F, Okamoto T, Kashiwagi H, Kanazawa K, Miyaki M, Konishi M, Tsukamoto T
    Cancer 82 279-285 Jan. 1998
  • Genotypes of GB virus C and hepatitis C virus in hepatitis patients in India, Iran and Slovenia
    Sawant P, Upadhyay A.P, Levicnik-Stezinar S, Zali M.R, Okamoto H
    Hepatology Research 10(2) 175-183 1998
  • Hepatitis C virus infection in patients with urticaria [4] (multiple letters)
    Llanos F, Raison-Pevron N, Meunier L, Ducos J, Meynadier J, Kanazawa K, Okamoto H
    Journal of the American Academy of Dermatology 38(4) 1998
  • Hepatitis TT virus is present in New Zealand.
    Graeme Woodfield D, Gane E, Okamoto H
    The New Zealand medical journal 111(1066) 195-196 1998
  • High-dose (9 MU) long-term (60 weeks) alfa-interferon therapy for chronic hepatitis patients infected with HCV genotype 1b
    Kanai K, Kako M, Kumada T, Tsubouchi H, Aikawa T, Kojima M, Harada H, Kawasaki T, Nakashima M, Okamoto H, Mishiro S
    Archives of Virology 143(8) 1545-1554 1998
  • Incidence and influence of GB virus C and hepatitis C virus infection in patients undergoing bone marrow transplantation
    Akiyama H, Nakamura N, Tanikawa S, Sakamaki H, Onozawa Y, Shibayama T, Tanaka S, Tsuda F, Okamoto H, Miyakawa Y, Mayumi M
    Bone Marrow Transplantation 21(11) 1131-1135 1998
  • Infection with an unenveloped DNA virus (TTV) associated with posttransfusion non-A to G hepatitis in hepatitis patients and healthy blood donors in Thailand
    Tanaka H, Okamoto H, Luengrojanakul P, Chainuvati T, Tsuda F, Tanaka T, Miyakawa Y, Mayumi M
    Journal of Medical Virology 56(3) 234-238 1998
  • Molecular cloning and characterization of a novel DNA virus (TTV) associated with posttransfusion hepatitis of unknown etiology
    Okamoto H, Nishizawa T, Kato N, Ukita M, Ikeda H, Iizuka H, Miyakawa Y, Mayumi M
    Hepatology Research 10(1) 1-16 1998
  • Prevalence of anti-hepatitis C antibodies in a rural community without high mortality from liver disease in niigata prefecture
    Kayaba K, Igarashi M, Okamoto H, Tsuda F
    Journal of Epidemiology 8(4) 250-255 1998
  • The entire nucleotide sequences of three hepatitis C virus isolates in genetic groups 7-9 and comparison with those in the other eight genetic groups
    Tokita H, Okamoto H, Iizuka H, Kishimoto J, Tsuda F, Miyakawa Y, Mayumi M
    Journal of General Virology 79(8) 1847-1857 1998
  • Transfusion transmitted virus.
    Fujiwara T, Iwata A, Iizuka H, Tanaka T, Okamoto H
    Lancet 352(9136) 1310-1311 1998
  • Twenty-four week administration of recombinant interferon alfa 2a for chronic hepatitis B
    Kanai K, Kako M, Aikawa T, Hino K, Tsubouchi H, Takehira Y, Iwabuchi S, Kawasaki T, Tsuda F, Okamoto H, Mayumi M
    Acta Hepatologica Japonica 39(2) 62-67 1998
  • A monoclonal antibody against a hepatitis B e antigen epitope borne by six amino acids encoded by the precore region.
    Usuda S, Okamoto H, Ohnuma H, Tanaka T, Machida A, Miyakawa Y, Mayumi M
    Journal of virological methods 68 207-215 Nov. 1997
  • Loss of circulating hepatitis C virus in children who developed a persistent carrier state after mother-to-baby transmission.
    Sasaki N, Matsui A, Momoi M, Tsuda F, Okamoto H
    Pediatric research 42 263-267 Sep. 1997
  • B cell malignancy and hepatitis C virus infection.
    Izumi T, Sasaki R, Tsunoda S, Akutsu M, Okamoto H, Miura Y
    Leukemia 11 Suppl 3 516-518 Apr. 1997
  • The entire nucleotide sequences of two GB virus C/hepatitis G virus isolates of distinct genotypes from Japan.
    Okamoto H, Nakao H, Inoue T, Fukuda M, Kishimoto J, Iizuka H, Tsuda F, Miyakawa Y, Mayumi M
    The Journal of general virology 78 ( Pt 4) 737-745 Apr. 1997
  • [Hepatitis G virus (HGBV-C/HGV) as a putative agent for non-A to E hepatitis].
    Okamoto H
    Nihon rinsho. Japanese journal of clinical medicine 55 515-522 Mar. 1997
  • A monoclonal antibody against a hepatitis B e antigen epitope borne by six amino acids encoded by the precore region
    Usuda S, Okamoto H, Ohnuma H, Tanaka T, Machida A, Miyakawa Y, Mayumi M
    Journal of Virological Methods 68(2) 207-215 1997
  • A novel DNA virus (TTV) associated with elevated transaminase levels in posttransfusion hepatitis of unknown etiology
    Nishizawa T, Okamoto H, Konishi K, Yoshizawa H, Miyakawa Y, Mayumi M
    Biochemical and Biophysical Research Communications 241(1) 92-97 1997
  • Antibodies to hepatitis C virus and elevated transaminase levels in a town of hyperendemicity in Iwate, Japan
    Koyama T, Tsuda F, Ishikawa K, Oishi H, Tazawa M, Yoshizawa H, Sato S, Okamoto H
    Journal of Gastroenterology and Hepatology 12(1) 67-72 1997
  • B cell malignancy and hepatitis C virus infection
    Izumi T, Sasaki R, Tsunoda S, Akutsu M, Okamoto H, Miura Y
    Leukemia 11(SUPPL. 3) 516-518 1997
  • Co-infection with GB virus C in an area of high endemicity for human T-lymphotropic virus type I in Japan [2]
    Chiyoda S, Inoue J, Okamoto H
    Infection 25(2) 129-130 1997
  • Cytotoxic T lymphocyte response and viral load in hepatitis C virus infection
    Hiroishi K, Kita H, Kojima M, Okamoto H, Moriyama T, Kaneko T, Ishikawa T, Ohnishi S, Aikawa T, Tanaka N, Yazaki Y, Mitamura K, Imawari M
    Hepatology 25(3) 705-712 1997
  • Effect of interferon on GB virus C and hepatitis C virus in hepatitis patients with the co-infection
    Nagayama R, Miyake K, Okamoto H
    Journal of Medical Virology 52(2) 156-160 1997
  • GB virus C and hepatitis C virus infections in hemodialysis patients in eight Japanese centers
    Okamoto H
    Nephron 76(2) 171-175 1997
  • Hepatitis G virus (HGBV-C/HGV) as a putative agent for non-A to E hepatitis
    Okamoto H
    Nippon rinsho. Japanese journal of clinical medicine 55(3) 515-522 1997
  • High prevalence of hepatitis C virus infection in Japanese patients with porphyria cutanea tarda [3]
    Kondo M, Horie Y, Okano J.-I, Kitamura A, Maeda N, Kawasaki H, Mishiro S, Yamamoto S.-I, Saeki S.-I, Okamoto H
    Hepatology 26(1) 1997
  • Impaired induction of cytotoxic T lymphocytes by antagonism of a weak agonist borne by a variant hepatitis C virus epitope
    Kaneko T, Moriyama T, Udaka K, Hiroishi K, Kita H, Okamoto H, Yagita H, Okumura K, Imawari M
    European Journal of Immunology 27(7) 1782-1787 1997
  • Infection with GB virus C and hepatitis C virus in drug addicts, patients on maintenance hemodialysis, or with chronic liver disease in Nepal
    Shrestha S.M, Shrestha S, Tsuda F, Sawada N, Tanaka T, Okamoto H, Miyakawa Y, Mayumi M
    Journal of Medical Virology 53(2) 157-161 1997
  • Infection with GB virus C and hepatitis C virus in hemodialysis patients and blood donors in Beijing
    Wang Y, Chen H.-S, Fan M.-H, Liu H.-L, An P, Sawada N, Tanaka T, Tsuda F, Okamoto H
    Journal of Medical Virology 52(1) 26-30 1997
  • Infection with GB virus C in patients with chronic liver disease
    Sugai Y, Nakayama H, Fukuda M, Sawada N, Tanaka T, Tsuda F, Okamoto H, Miyakawa Y, Mayumi M
    Journal of Medical Virology 51(3) 175-181 1997
  • Infection with GB virus C in the patients with primary hepatocellular carcinoma in Japan
    Shibayama T, Hayashi S, Saeki S, Tanaka T, Ohtake H, Tanaka S, Sawada N, Okamoto H
    Hepatology Research 8(1) 37-43 1997
  • Infection with hepatitis G virus (GBV-C/HGV) in patients with chronic liver disease
    Kojima M, Kanazawa K, Hakamada T, Aikawa T, Sawada N, Tsuda F, Okamoto H
    Acta Hepatologica Japonica 38(9) 535-540 1997
  • Infection with hepatitis G virus and its strain variant, the GB agent (GBV-C), among blood donors in Japan
    Yoshikawa A, Fukuda S, Itoh K, Kosaki N, Suzuki T, Hirakawa K, Nakao H, Inoue T, Fukuda M, Okamoto H
    Transfusion 37(6) 657-663 1997
  • Loss of circulating hepatitis C virus in children who developed a persistent carrier state after mother-to-baby transmission
    Sasaki N, Matsui A, Momoi M, Tsuda F, Okamoto H
    Pediatric Research 42(3) 263-267 1997
  • Molecular investigation of GB virus C infection in hemophiliacs in Japan
    Kinoshita T, Miyake K, Nakao H, Tanaka T, Tsuda F, Okamoto H, Miyakawa Y, Mayumi M
    Journal of Infectious Diseases 175(2) 454-457 1997
  • Mutation rate of GB virus C/hepatitis G virus over the entire genome and in subgenomic regions
    Nakao H, Okamoto H, Fukuda M, Tsuda F, Mitsui T, Masuko K, Iizuka H, Miyakawa Y, Mayumi M
    Virology 233(1) 43-50 1997
  • Regularities in the Prevalence of Hepatitis C Virus and Its Genotypes in Russia and the Former Ussr Countries
    Lvov D.K, Samokhvalov Ye.I, Mishiro S, Tsuda F, Selivanov N.A, Okamoto H, Stakhanova V.M, Gromashevsky V.L, Aristova V.A, Doroshenko N.V, Yashina T.L, Kuzin S.N, Suetina I.A, Lobanov D.S, Deryabin P.G, Ruzayeva L.A, Bezgodov V.N, Frizen V.I, Firsova L.A, Firsova L.I, Darizhapov B.B, Lvov S.D, Smirnov V.N, Lisitsyna V.Ye, Krel P.Ye, Malyshev V.S, Takmakov V.S, Ogarkov P.I, Sorinson S.N, Shakhgildyan I.V, Khodyakova I.A, Marchuk A.I, Schukina I.A
    Voprosy Virusologii 42(4) 157-161 1997
  • Response to interferon of GB virus C and hepatitis C virus in patients with chronic hepatitis
    Inoue T, Sakamoto M, Akahane Y, Okamoto H, Miyakawa Y, Mayumi M
    American Journal of Gastroenterology 92(11) 1981-1985 1997
  • Response to interferon-α2a in patients with e antigen-negative chronic hepatitis B
    Kako M, Kanai K, Aikawa T, Iwabuchi S, Takehira Y, Kawasaki T, Tsubouchi H, Hino K, Tsuda F, Okamoto H, Miyakawa Y, Mayumi M
    Journal of Clinical Gastroenterology 25(2) 440-445 1997
  • The entire nucleotide sequences of two GB virus C/hepatitis G virus isolates of distinct genotypes from Japan
    Okamoto H, Nakao H, Inoue T, Fukuda M, Kishimoto J, Iizuka H, Tsuda F, Miyakawa Y, Mayumi M
    Journal of General Virology 78(4) 737-745 1997
  • The molecular basis of hepatitis B e antigen (HBeAg)-negative infections
    Miyakawa Y, Okamoto H, Mayumi M
    Journal of Viral Hepatitis 4(1) 1-8 1997
  • Transmission of GB virus C by blood transfusions during heart surgery
    Shimizu M, Osada K, Okamoto H
    Vox Sanguinis 72(2) 76-78 1997
  • Hepatitis C virus infection in patients with urticaria.
    Kanazawa K, Yaoita H, Tsuda F, Okamoto H
    Journal of the American Academy of Dermatology 35 195-198 Aug. 1996
  • [Molecular evolution of hepatitis C virus and its closely related virus].
    Okamoto H
    Uirusu 46 13-21 Jun. 1996
  • A second-generation method of genotyping hepatitis C virus by the polymerase chain reaction with sense and antisense primers deduced from the core gene.
    Okamoto H, Kobata S, Tokita H, Inoue T, Woodfield GD, Holland PV, Al-Knawy BA, Uzunalimoglu O, Miyakawa Y, Mayumi M
    Journal of virological methods 57 31-45 Mar. 1996
  • Hepatitis C virus variants from Jakarta, Indonesia classifiable into novel genotypes in the second (2e and 2f), tenth (10a) and eleventh (11a) genetic groups.
    Tokita H, Okamoto H, Iizuka H, Kishimoto J, Tsuda F, Lesmana LA, Miyakawa Y, Mayumi M
    The Journal of general virology 77 ( Pt 2 ) 293-301 Feb. 1996
  • A second-generation method of genotyping hepatitis C virus by the polymerase chain reaction with sense and antisense primers deduced from the core gene
    Okamoto H, Kobata S, Tokita H, Inoue T, Woodfield G.D, Holland P.V, Al-Knawy B.A, Uzunalimoglu O, Miyakawa Y, Mayumi M
    Journal of Virological Methods 57(1) 31-45 1996
  • An easy dipstick assay for anti-core antibodies to screen blood donors for hepatitis C virus viremia
    Mulyanto Dr, Suwignyo S, Tsauri S, Itoh K, Mizui M, Tsuda F, Okamoto H, Yoshizawa H, Mishiro S
    Vox Sanguinis 70(4) 229-231 1996
  • Association of circulating hepatitis G virus with lipoproteins for a lack of binding with antibodies
    Sato K, Tanaka T, Okamoto H, Miyakawa Y, Mayumi M
    Biochemical and Biophysical Research Communications 229(3) 719-725 1996
  • B cell malignancy and hepatitis C virus infection.
    Izumi T, Sasaki R, Miura Y, Okamoto H
    Leukemia research 20(5) 1996
  • Cold activation of complement enhancing with the duration of storage in sera from blood donors with hepatitis C virus RNA
    Itoh K, Tanaka H, Shiga J, Hirakawa K, Tsuda F, Okamoto H, Miyakawa Y, Mayumi M
    International Hepatology Communications 5(2) 89-96 1996
  • Cold activation of complement for monitoring the response to interferon in patients with chronic hepatitis C
    Akahane Y, Miyazaki Y, Naitoh S, Takeda K, Tsuda F, Okamoto H, Itoh K, Miyakawa Y, Mayumi M
    American Journal of Gastroenterology 91(2) 319-324 1996
  • Core promoter mutations of hepatitis B virus for the response to interferon in E antigen-positive chronic hepatitis B
    Kanai K, Kako M, Aikawa T, Hino K, Tsubouchi H, Takehira Y, Iwabuchi S, Kawasaki T, Tsuda F, Okamoto H, Miyakawa Y, Mayumi M
    American Journal of Gastroenterology 91(10) 2150-2156 1996
  • Full-length genomic sequence of a hepatitis C virus genotype 2c isolate (BEBE1) and the 2c-specific PCR primers: Brief report
    Nakao H, Okamoto H, Tokita H, Inoue T, Iizuka H, Pozzato G, Mishiro S
    Archives of Virology 141(3-4) 701-704 1996
  • GBV-C in the aetiology of fulminant hepatitis [6]
    Kao J.-H, Chen P.-J, Chen D.-S, Mishiro S, Yoshiba M, Okamoto H
    Lancet 347(8994) 120-121 1996
  • Genotypes and multiple infections with hepatitis C virus in patients with haemophilia a in Japan
    Fujimura Y, Ishimoto S, Shimoyama T, Narita N, Kuze Y, Yoshioka A, Fukui H, Tanaka T, Tsuda F, Okamoto H, Miyakawa Y, Mayumi M
    Journal of Viral Hepatitis 3(2) 79-84 1996
  • Genotyping hepatitis C virus isolates from Spain, Brazil, China, and Macau by a simplified PCR method
    Holland P.V, Barrera J.M, Ercilla M.G, Yoshida C.F.T, Wang Y, De Olim G.A.B, Betlach B, Kuramoto K, Okamoto H
    Journal of Clinical Microbiology 34(10) 2372-2378 1996
  • Hepatitis B and C infection among drug abusers in Nepal.
    Shrestha S.M, Shrestha D.M, Gafney T.E, Maharjan K.G, Tsuda F, Okamoto H
    Tropical gastroenterology : official journal of the Digestive Diseases Foundation 17(4) 212-213 1996
  • Hepatitis C virus antibody, viral RNA and genotypes in leprous patients in Japan
    Egawa K, Yukawa T, Arakawa S, Tanaka T, Tsuda F, Okamoto H, Miyakawa Y, Mayumi M
    Journal of Hepatology 24(4) 397-402 1996
  • Hepatitis C virus genotypes and co-infection with GB virus C in patients with anti-HCV-positive chronic liver disease in Jakarta, Indonesia
    Lesmana L.A, Sulaiman H.A, Noer H.M.S, Tsuda F, Okamoto H
    International Hepatology Communications 6(1) 16-23 1996
  • Hepatitis C virus infection in patients with psoriasis [5]
    Kanazawa K, Aikawa T, Tsuda F, Okamoto H
    Archives of Dermatology 132(11) 1391-1392 1996
  • Hepatitis C virus infection in patients with urticaria
    Kanazawa K, Yaoita H, Tsuda F, Okamoto H
    Journal of the American Academy of Dermatology 35(2 I) 195-198 1996
  • Hepatitis C virus infection in Waldenstrom's macroglobulinemia [6]
    Izumi T, Sasaki R, Shimizu R, Miyazato A, Hoshino Y, Miura Y, Okamoto H
    American Journal of Hematology 52(3) 238-239 1996
  • Hepatitis C virus variants from Jakarta, Indonesia classifiable into novel genotypes in the second (2e and 2f), tenth (10a) and eleventh (11a) genetic groups
    Tokita H, Okamoto H, Lizuka H, Kishimoto J, Tsuda F, Lesmana L.A, Miyakawa Y, Mayumi M
    Journal of General Virology 77(2) 293-301 1996
  • Hepatitis G infection in drug abusers with chronic hepatitis C [4]
    Aikawa T, Sugai Y, Okamoto H
    New England Journal of Medicine 334(3) 195-196 1996
  • Hepatitis GB virus C [1]
    Sampietro M, Badalamenti S, Lunghi G, Yoshiba M, Inoue K, Sekiyama K, Tomas J.F, Bartolome J, Carreno V, Masuko K, Okamoto H, Mayumi M
    New England Journal of Medicine 335(18) 1392-1394 1996
  • HLA DRB1 and DQB1 alleles and haplotypes influencing the progression of hepatitis C
    Aikawa T, Kojima M, Onishi H, Tamura R, Fukuda S, Suzuki T, Tsuda F, Okamoto H, Miyakawa Y, Mayumi M
    Journal of Medical Virology 49(4) 274-278 1996
  • Infection with GB virus C (GBV-C) in patients with chronic liver disease or on maintenance hemodialysis in Indonesia
    Tsuda F, Hadiwandowo S, Sawada N, Fukuda M, Tanaka T, Okamoto H, Miyakawa Y, Mayumi M
    Journal of Medical Virology 49(3) 248-252 1996
  • Infection with GB virus C (GBV-C) in patients with fulminant hepatitis
    Tameda Y, Kosaka Y, Tagawa S, Takase K, Sawada N, Nakao H, Tsuda F, Tanaka T, Okamoto H, Miyakawa Y, Mayumi M
    Journal of Hepatology 25(6) 842-847 1996
  • Infection with GB virus C in female prisoners who were drug abusers in Japan [2]
    Yui K, Ishiguro T, Okamoto H
    Infection 24(5) 1996
  • Infection with GB virus C in leprous patients in Japan
    Egawa K, Yukawa T, Arakawa S, Nakao H, Inoue T, Tanaka T, Tsuda F, Okamoto H, Miyakawa Y, Mayumi M
    Journal of Medical Virology 49(2) 110-114 1996
  • Infection with hepatitis GB virus among Japanese hemophiliacs.
    Nishiyama Y, Nakashima H, Hino K, Mori K, Ishikawa M, Okamoto H
    Transfusion 36(7) 1996
  • Infection with hepatitis GB virus C in patients on maintenance hemodialysis
    Masuko K, Mitsui T, Iwano K, Yamazaki C, Okuda K, Meguro T, Murayama N, Inoue T, Tsuda F, Okamoto H, Miyakawa Y, Mayumi M
    New England Journal of Medicine 334(23) 1485-1490 1996
  • Molecular evolution of hepatitis C virus and its closely related virus
    Okamoto H
    Uirusu. Journal of virology 46(1) 13-21 1996
  • Mutations in the envelope gene of hepatitis B virus variants co-occurring with antibody to surface antigen in sera from patients with chronic hepatitis B
    Kohno H, Inoue T, Tsuda F, Okamoto H, Akahane Y
    Journal of General Virology 77(8) 1825-1831 1996
  • Prevalence of hepatitis C virus and distribution of its genotypes in Northern Eurasia
    Lvov D.K, Samokhvalov E.I, Tsuda F, Selivanov N.A, Okamoto H, Stakhanova V.M, Stakhgildyan I.V, Doroshenko N.V, Yashina T.L, Kuzin S.N, Suetina I.A, Deryabin P.G, Ruzaeva L.A, Bezgodov V.N, Firsova L.A, Sorinson S.N, Mishiro S
    Archives of Virology 141(9) 1613-1622 1996
  • Primary hepatosplenic lymphoma: Association with hepatitis C virus infection [2]
    Izumi T, Sasaki R, Miura Y, Okamoto H
    Blood 87(12) 5380-5381 1996
  • Reduced precore transcription and enhanced core-pregenome transcription of hepatitis B virus DNA after replacement of the precore-core promoter with sequences associated with e antigen-seronegative persistent infections
    Moriyama K, Okamoto H, Tsuda F, Mayumi M
    Virology 226(2) 269-280 1996
  • Transfusion-transmitted hepatitis G virus following open heart surgery.
    Shimizu M, Osada K, Okamoto H
    Transfusion 36(10) 1996
  • Full-length genomic sequence of a hepatitis C virus genotype 2c isolate (BEBE1) and the 2c-specific PCR primers.
    Nakao H, Okamoto H, Tokita H, Inoue T, Iizuka H, Pozzato G, Mishiro S
    Archives of virology 141 701-704 1996
  • [Anti-HBs escape mutants--implication of neutralization escape and diagnostic escape].
    Okamoto H
    Nihon rinsho. Japanese journal of clinical medicine 53 Suppl 212-222 Oct. 1995
  • [Classification of hepatitis C virus genotypes and its application to molecular epidemiology].
    Okamoto H
    Nihon rinsho. Japanese journal of clinical medicine 53 Suppl 71-79 Sep. 1995
  • Hepatitis C virus variants from Thailand classifiable into five novel genotypes in the sixth (6b), seventh (7c, 7d) and ninth (9b, 9c) major genetic groups.
    Tokita H, Okamoto H, Luengrojanakul P, Vareesangthip K, Chainuvati T, Iizuka H, Tsuda F, Miyakawa Y, Mayumi M
    The Journal of general virology 76 ( Pt 9) 2329-2335 Sep. 1995
  • [PCR-based genotyping with genotype-specific primers derived from the C gene of HCV genome].
    Okamoto H
    Nihon rinsho. Japanese journal of clinical medicine 53 Suppl 312-320 Sep. 1995
  • A common-source outbreak of fulminant hepatitis B in hemodialysis patients induced by precore mutant
    Tanaka S, Yoshiba M, Iino S, Fukuda M, Nakao H, Tsuda F, Okamoto H, Miyakawa Y, Mayumi M
    Kidney International 48(6) 1972-1978 1995
  • A minimal and optimal cytotoxic T cell epitope within hepatitis C virus nucleoprotein
    Kita H, Hiroishi K, Moriyama T, Okamoto H, Kaneko T, Ohnishi S, Yazaki Y, Imawari M
    Journal of General Virology 76(12) 3189-3193 1995
  • A unique set of mutations in the 'preX' region of hepatitis B virus DNA frequently found in patients but not in asymptomatic carriers: Implication for a novel variant
    Takahashi K, Kishimoto S, Ohori K, Yoshizawa H, Akahane Y, Okamoto H, Mishiro S
    International Hepatology Communications 3(3) 131-138 1995
  • Anti-HBs escape mutants--implication of neutralization escape and diagnostic escape
    Okamoto H
    Nippon rinsho. Japanese journal of clinical medicine 53 Suppl(Pt 2) 212-222 1995
  • Association of prurigo with hepatitis C virus infection [5]
    Kanazawa K, Yaoita H, Tsuda F, Murata K, Okamoto H
    Archives of Dermatology 131(7) 852-853 1995
  • Classification of hepatitis C virus genotypes and its application to molecular epidemiology
    Okamoto H
    Nippon rinsho. Japanese journal of clinical medicine 53 Suppl 71-79 1995
  • Classifying hepatitis C virus genotypes
    Miyakawa Y, Okamoto H, Mayumi M
    Molecular Medicine Today 1(1) 20-25 1995
  • Clearance of serum hepatitis C virus RNA after interferon therapy in relation to virus genotype
    Kanai K, Kako M, Aikawa T, Kumada T, Kawasaki T, Hatahara T, Oka Y, Mizokami M, Sakai T, Iwata K, Okamoto H, Mayumi M
    Liver 15(4) 185-188 1995
  • Cold activation of complement as a marker of hepatitis c viremia in sera from blood donors
    Itoh K, Tanaka H, Shiga J.-I, Hirakawa K, Tanaka T, Akahane Y, Tsuda F, Okamoto H, Miyakawa Y, Mayumi M
    Transfusion Science 16(3) 283-289 1995
  • Detection of the GBV-C hepatitis virus genome in serum from patients with fulminant hepatitis of unknown aetiology
    Yoshiba M, Okamoto H, Mishiro S
    Lancet 346(8983) 1131-1132 1995
  • HCV RNA monitoring for tailored regimens of interferon therapy in hepatitis C
    Kanai K, Kako M, Aikawa T, Kumada T, Kawasaki T, Hatahara T, Oka Y, Mizokami M, Sakai T, Iwata K, Okamoto H, Mayumi M, Mishiro S
    Biomedicine and Pharmacotherapy 49(2) 65-67 1995
  • Hepatitis B virus strains with mutations in the core promoter in patients with fulminant hepatitis
    Sato S, Suzuki K, Akahane Y, Akamatsu K, Akiyama K, Yunomura K, Tsuda F, Tanaka T, Okamoto H, Miyakawa Y, Mayumi M
    Annals of Internal Medicine 122(4) 241-248 1995
  • Hepatitis C virus type 1b (II) infection in France and Italy
    Nousbaum J.-B, Pol S, Nalpas B, Landais P, Berthelot P, Brechot C, Gigou M, Feray C, Thiers V, Okamoto H, Mishiro S, Poussin K, Paterlini P, Rumi M, Colombo M
    Annals of Internal Medicine 122(3) 161-168 1995
  • Hepatitis C virus variants from Thailand classifiable into five novel genotypes in the sixth (6b), seventh (7c, 7d) and ninth (9b, 9c) major genetic groups
    Tokita H, Okamoto H, Luengrojanakul P, Vareesangthip K, Chainuvati T, Iizuka H, Tsuda F, Miyakawa Y, Mayumi M
    Journal of General Virology 76(9) 2329-2335 1995
  • HLA B44-restricted cytotoxic T lymphocyte responses to the peptides of HCV nucleoprotein residues 81-100 in patients with chronic hepatitis C
    Kita H, Moriyama T, Kaneko T, Okamoto H, Hiroishi K, Ohnishi S, Imawari M
    Journal of Gastroenterology 30(6) 809-812 1995
  • Influence of the genotypes of hepatitis C virus on the severity of recurrent liver disease after liver transplantation
    Féray C, Gigou M, Samuel D, Paradis V, Mishiro S, Maertens G, Reynés M, Okamoto H, Bismuth H, Bréchot C
    Gastroenterology 108(4) 1088-1096 1995
  • Interferon-alpha 2a for chronic hepatitis B with e antigen or antibody:comparable antiviral effects on wild-type virus and precore mutant.
    Aikawa T, Kanai K, Kako M, Kawasaki T, Hino K, Iwabuchi S, Tsubouchi H, Takehira Y, Tsuda F, Okamoto H
    Journal of viral hepatitis 2(5) 243-250 1995
  • Moleclar and cinical characteristics of the hepatitis C virus genotype '2c' found in Italians in Italy and France
    Okamoto H, Crovatto M, Pozzato G, Feray C, Brechot C, Mishiro S
    International Hepatology Communications 3(3) 161-165 1995
  • PCR-based genotyping with genotype-specific primers derived from the C gene of HCV genome
    Okamoto H
    Nippon rinsho. Japanese journal of clinical medicine 53 Suppl 312-320 1995
  • Rebound of hepatitis C virus RNA in serum after withdrawal of interferon in patients with advanced liver disease
    Tsukamoto M, Miyazaki Y, Okamoto H, Akahane Y
    International Hepatology Communications 3(1) 26-34 1995
  • Transmission of hepatitis C virus to spouses [1]
    Mauser-Bunschoten E.P, Bresters D, Reesink H.W, Akahane Y, Tsuda F, Okamoto H
    Annals of Internal Medicine 122(2) 154-155 1995
  • Hepatitis B virus with mutations in the core promoter for an e antigen-negative phenotype in carriers with antibody to e antigen.
    Okamoto H, Tsuda F, Akahane Y, Sugai Y, Yoshiba M, Moriyama K, Tanaka T, Miyakawa Y, Mayumi M
    Journal of virology 68 8102-8110 Dec. 1994
  • Hepatitis C virus variants from Vietnam are classifiable into the seventh, eighth, and ninth major genetic groups.
    Tokita H, Okamoto H, Tsuda F, Song P, Nakata S, Chosa T, Iizuka H, Mishiro S, Miyakawa Y, Mayumi M
    Proceedings of the National Academy of Sciences of the United States of America 91 11022-11026 Nov. 1994
  • Superinfection of chimpanzees carrying hepatitis C virus of genotype II/1b with that of genotype III/2a or I/1a.
    Okamoto H, Mishiro S, Tokita H, Tsuda F, Miyakawa Y, Mayumi M
    Hepatology (Baltimore, Md.) 20 1131-1136 Nov. 1994
  • [PCR-based HCV genotyping with type-specific primers derived from core gene and IFN responsiveness].
    Okamoto H
    Nihon rinsho. Japanese journal of clinical medicine 52 1699-1706 Jul. 1994
  • Hepatitis C virus variants from Nepal with novel genotypes and their classification into the third major group.
    Tokita H, Shrestha SM, Okamoto H, Sakamoto M, Horikita M, Iizuka H, Shrestha S, Miyakawa Y, Mayumi M
    The Journal of general virology 75 ( Pt 4) 931-936 Apr. 1994
  • Naturally occurring escape mutants of hepatitis B virus with various mutations in the S gene in carriers seropositive for antibody to hepatitis B surface antigen.
    Yamamoto K, Horikita M, Tsuda F, Itoh K, Akahane Y, Yotsumoto S, Okamoto H, Miyakawa Y, Mayumi M
    Journal of virology 68 2671-2676 Apr. 1994
  • The entire nucleotide sequence and classification of a hepatitis C virus isolate of a novel genotype from an Indonesian patient with chronic liver disease.
    Okamoto H, Kojima M, Sakamoto M, Iizuka H, Hadiwandowo S, Suwignyo S, Miyakawa Y, Mayumi M
    The Journal of general virology 75 ( Pt 3) 629-635 Mar. 1994
  • Anti-preS2 neutralizes the hepatitis B virus variant with a vaccine-escape mutation at the amino acid position 126 or 145 within the S gene
    Machida A, Okamoto H, Tsuda F, Tanaka T, Domoto K, Mishiro S
    International Hepatology Communications 2(3) 186-189 1994
  • Contribution of hepatitis C virus to non-A, non-B fulminant hepatitis in Japan
    Yoshiba M, Dehara K, Inoue K, Okamoto H, Mayumi M
    Hepatology 19(4) 829-835 1994
  • Differences in the entire nucleotide sequence between hepatitis B virus genomes from carriers positive for antibody to hepatitis B e antigen with and without active disease
    Horikita M, Itoh S, Yamamoto K, Shibayama T, Tsuda F, Okamoto H
    Journal of Medical Virology 44(1) 96-103 1994
  • Entire nucleotide sequence and characterization of a hepatitis C virus of genotype V/3a
    Sakamoto M, Akahane Y, Tsuda F, Tanaka T, Woodfield D.G, Okamoto H
    Journal of General Virology 75(7) 1761-1768 1994
  • Genetic heterogeneity of hepatitis C virus
    Okamoto H, Mishiro S
    Intervirology 37(2) 68-76 1994
  • Genotype of hepatitis C virus in fulminant hepatitis C [3]
    Yoshiba M, Sekiyama K, Inoue K, Sugata F, Okamoto H
    Digestive Diseases and Sciences 39(1) 220-221 1994
  • Genotypes and titers of hepatitis C virus for predicting response to interferon in patients with chronic hepatitis C
    Hino K, Sainokami S, Shimoda K, Iino S, Wang Y, Okamoto H, Miyakawa Y, Mayumi M
    Journal of Medical Virology 42(3) 299-305 1994
  • Hepatitis B virus subtypes and hepatitis C virus genotypes in patients with chronic liver disease in Nepal
    Shrestha S.M, Tsuda F, Okamoto H, Tokita H, Horikita M, Tanaka T, Miyakawa Y, Mayumi M
    Hepatology 19(4) 805-809 1994
  • Hepatitis B virus subtypes and hepatitis C virus genotypes in patients with chronic liver disease or on maintenance hemodialysis in Indonesia
    Hadiwandowo S, Tsuda F, Okamoto H, Tokita H, Wang Y, Tanaka T, Miyakawa Y, Mayumi M
    Journal of Medical Virology 43(2) 182-186 1994
  • Hepatitis B virus with mutations in the core promoter for an e antigen-negative phenotype in carriers with antibody to e antigen
    Okamoto H, Tsuda F, Akahane Y, Sugai Y, Yoshiba M, Moriyama K, Tanaka T, Miyakawa Y, Mayumi M
    Journal of Virology 68(12) 8102-8110 1994
  • Hepatitis C and B virus infections in populations at low or high risk in Ho Chi Minh and Hanoi, Vietnam
    Nakata S, Song P, Dao Dinh Duc, Nguyen Xuan Quang, Murata K, Tsuda F, Okamoto H
    Journal of Gastroenterology and Hepatology 9(4) 416-419 1994
  • Hepatitis C virus antibodies, viral RNA and genotypes in sera from patients on maintenance haemodialysis
    Masuko K, Okuda K, Meguro T, Murayama N, Mitsui T, Ohmori T, Murata K, Tsuda F, Okamoto H
    J.VIRAL HEPATITIS 1(1) 65-71 1994
  • Hepatitis C virus infection in patients with chronic liver disease or chronic renal failure and blood donors in Thailand
    Luengrojanakul P, Vareesangthip K, Chainuvati T, Murata K, Tsuda F, Tokita H, Okamoto H, Miyakawa Y, Mayumi M
    Journal of Medical Virology 44(3) 287-292 1994
  • Hepatitis C virus infection in spouses of patients with type C chronic liver disease
    Akahane Y, Kojima M, Sugai Y, Sakamoto M, Miyazaki Y, Tanaka T, Tsuda F, Mishiro S, Okamoto H, Miyakawa Y, Mayumi M
    Annals of Internal Medicine 120(9) 748-752 1994
  • Hepatitis C virus RNA and antibodies among blood donors in Beijing
    Wang Y, Tao Q.-M, Zhao H.-Y, Tsuda F, Nagayama R, Yamamoto K, Tanaka T, Tokita H, Okamoto H, Miyakawa Y, Mayumi M
    Journal of Hepatology 21(4) 634-640 1994
  • Hepatitis C virus RNA in blood units with antibodies detectable by a second-generation passive hemagglutination assay, antibodies to synthetic core peptides or elevated transaminase levels
    Fukuda S, Suzuki T, Nagayama R, Tsuda F, Kojima M, Okamoto H, Tanaka T, Miyakawa Y, Mayumi M
    Transfusion Science 15(1) 83-92 1994
  • Hepatitis C virus variants from Nepal with novel genotypes and their classification into the third major group
    Tokita H, Shrestha S.M, Okamoto H, Sakamoto M, Horikita M, Iizuka H, Shrestha S, Miyakawa Y, Mayumi M
    Journal of General Virology 75(4) 931-936 1994
  • Hepatitis C virus variants from Vietnam are classifiable into the seventh, eighth, and ninth major genetic groups
    Tokita H, Okamoto H, Tsuda F, Song P, Nakata S, Chosa T, Iizuka H, Mishiro S, Miyakawa Y, Mayumi M
    Proceedings of the National Academy of Sciences of the United States of America 91(23) 11022-11026 1994
  • High rate of hepatitis C virus transmission to spouses from hepatitis patients with a history of transfusion
    Ueno N, Sugaya H, Harada T, Tsuda F, Okamoto H
    International Hepatology Communications 2(5) 250-256 1994
  • Hypocomplementemia associated with hepatitis C viremia in sera from voluntary blood donors
    Itoh K, Tanaka H, Shiga J.-I, Hirakawa K, Akahane Y, Tsuda F, Okamoto H, Miyakawa Y, Mayumi M
    American Journal of Gastroenterology 89(11) 2019-2024 1994
  • Identification and genotyping of hepatitis C virus in injectable and oral drug users in New Zealand.
    Woodfield D.G, Harness M, Rix-Trott K, Tsuda F, Okamoto H, Mayumi M
    Australian and New Zealand Journal of Medicine 24(1) 47-50 1994
  • IgM antibody to a hepatitis C virus core peptide (CP14) for monitoring activity of liver disease in patients with acute or chronic hepatitis C
    Nagayama R, Miyake K, Tsuda F, Okamoto H
    Journal of Medical Virology 42(3) 311-317 1994
  • Influence of antibodies to the hypervariable region of E2/NS1 glycoprotein on the selective replication of hepatitis C virus in chimpanzees
    Kojima M, Osuga T, Tsuda F, Tanaka T, Okamoto H
    Virology 204(2) 665-672 1994
  • Intrafamilial clustering of genotypes of hepatitis C virus RNA.
    Takahashi M, Yamada G, Doi T, Takatani M, Kishi F, Miyamoto R, Yoshizawa H, Okamoto H, Tsuji T
    Acta Medica Okayama 48(6) 293-297 1994
  • Markers of hepatitis C and B virus infections among blood donors in Ho Chi Minh City and Hanoi, Vietnam
    Song P, Duc D.D, Hien B, Nakta S, Chosa T, Watanabe J, Tsuda F, Murata K, Okamoto H
    Clinical and Diagnostic Laboratory Immunology 1(4) 413-418 1994
  • Naturally occurring escape mutants of hepatitis B virus with various mutations in the S gene in carriers seropositive for antibody to hepatitis B surface antigen
    Yamamoto K, Horikita M, Tsuda F, Itoh K, Akahane Y, Yotsumoto S, Okamoto H, Miyakawa Y, Mayumi M
    Journal of Virology 68(4) 2671-2676 1994
  • PCR-based HCV genotyping with type-specific primers derived from core gene and IFN responsiveness
    Okamoto H
    Nippon rinsho. Japanese journal of clinical medicine 52(7) 1699-1706 1994
  • Prediction of interferon effect in chronic hepatitis C by both quantification and genotyping of HCV-RNA [1]
    Yamada G, Takahashi M, Miyamoto R, Tsuji T, Yoshizawa H, Okamoto H
    Digestive Diseases and Sciences 39(2) 1994
  • Prompt decrease of circulating hepatitis C virus in patients with chronic hepatitis C after treatment with interferon
    Saitoh H, Naitoh S, Okamoto H, Akahane Y
    Journal of Interferon Research 14(5) 239-244 1994
  • Pulmonary hypertension in systemic lupus erythematosus: a report of an autopsied case.
    Sato M, Okazaki H, Okamoto H, Ohtaka A, Shimizu H, Minato N, Kano S
    Internal medicine (Tokyo, Japan) 33(9) 540-542 1994
  • Safety and efficacy of a recombinant yeast-derived pre-S2 + S-containing hepatitis B vaccine (TGP 943): Phase 1, 2 and 3 clinical testing
    Suzuki H, Iino S, Shiraki K, Akahane Y, Okamoto H, Domoto K, Mishiro S
    Vaccine 12(12) 1090-1096 1994
  • Superinfection of chimpanzees carrying hepatitis C virus of genotype II/1b with that of genotype III/2a or I/1a
    Okamoto H, Mishiro S, Tokita H, Tsuda F, Miyakawa Y, Mayumi M
    Hepatology 20(5) 1131-1136 1994
  • The entire nucleotide sequence and classification of a hepatitis C virus isolate of a novel genotype from an Indonesian patient with chronic liver disease
    Okamoto H, Kojima M, Sakamoto M, Iizuka H, Hadiwandowo S, Suwignyo S, Miyakawa Y, Mayumi M
    Journal of General Virology 75(3) 629-635 1994
  • Transmission of hepatitis C virus from mothers to infants
    Ohto H, Terazawa S, Sasaki N, Sasaki N, Hino K, Ishiwata C, Kako M, Ujiie N, Endo C, Matsui A, Okamoto H, Mishiro S, Kojima M, Aikawa T, Shimoda K, Sakamoto M, Akahane Y, Yoshizawa H, Tanaka T, Tokita H, Tsuda F
    New England Journal of Medicine 330(11) 744-750 1994
  • Type-specific antibodies to hepatitis C virus in patients with chronic hepatitis C for predicting response to interferon alfa
    Yunomura K, Sugaya H, Harada T, Tsuda F, Okamoto H
    International Hepatology Communications 2(4) 201-206 1994
  • Vertical transmission of hepatitis C virus [1]
    Simon H.J, Gurakan B, Oran O, Yigit S, Tighe M.K, Miskovitz P, Leon J, Ohto H, Okamoto H, Mishiro S
    New England Journal of Medicine 331(6) 399-400 1994
  • Genetic heterogeneity of hepatitis C virus.
    Okamoto H, Mishiro S
    Intervirology 37 68-76 1994
  • [Genetic mutation of hepatitis C virus and host's immune response].
    Okamoto H
    Uirusu 43 305-313 Dec. 1993
  • Characterization of the genomic sequence of type V (or 3a) hepatitis C virus isolates and PCR primers for specific detection.
    Okamoto H, Tokita H, Sakamoto M, Horikita M, Kojima M, Iizuka H, Mishiro S
    The Journal of general virology 74 ( Pt 11) 2385-2390 Nov. 1993
  • Trans-complementation among naturally occurring deletion mutants of hepatitis B virus and integrated viral DNA for the production of viral particles with mutant genomes in hepatoma cell lines.
    Okamoto H, Wang Y, Tanaka T, Machida A, Miyakawa Y, Mayumi M
    The Journal of general virology 74 ( Pt 3) 407-414 Mar. 1993
  • Allelic subtypic determinants of hepatitis B surface antigen (i and t) that are distinct from d/y or w/r.
    Ohnuma H, Machida A, Okamoto H, Tsuda F, Sakamoto M, Tanaka T, Miyakawa Y, Mayumi M
    Journal of virology 67 927-932 Feb. 1993
  • A structurally flexible and antigenically variable N-terminal domain of the hepatitis C virus E2/NS1 protein: Implication for an escape from antibody
    Taniguchi S, Okamoto H, Sakamoto M, Kojima M, Tsuda F, Tanaka T, Munekata E, Muchmore E.E, Peterson D.A, Mishiro S
    Virology 195(1) 297-301 1993
  • Allelic subtypic determinants of hepatitis B surface antigen (i and t) that are distinct from d/y or w/r
    Ohnuma H, Machida A, Okamoto H, Tsuda F, Sakamoto M, Tanaka T, Miyakawa Y, Mayumi M
    Journal of Virology 67(2) 927-932 1993
  • Characterization of the genomic sequence of type V (or 3a) hepatitis C virus isolates and PCR primers for specific detection
    Okamoto H, Tokita H, Sakamoto M, Horikita M, Kojima M, Iizukas H, Mishiro S
    Journal of General Virology 74(11) 2385-2390 1993
  • Chimeric hepatitis B virus core particles with parts or copies of the hepatitis C virus core protein
    Yoshikawa A, Tanaka T, Hoshi Y, Kato N, Tachibana K, Iizuka H, Machida A, Okamoto H, Yamasaki M, Miyakawa Y, Mayumi M
    Journal of Virology 67(10) 6064-6070 1993
  • Demonstration of sugar moiety on the surface of hepatitis C virions recovered from the circulation of infected humans
    Sato K, Okamoto H, Aihara S, Hoshi Y, Tanaka T, Mishiro S
    Virology 196(1) 354-357 1993
  • Genetic mutation of hepatitis C virus and host's immune response
    Okamoto H
    Virus 43(2) 305-313 1993
  • Genotype dependence of hepatitis C virus antibodies detectable by the first-generation enzyme-linked immunosorbent assay with C100-3 protein
    Nagayama R, Tsuda F, Okamoto H, Wang Y, Mitsui T, Tanaka T, Miyakawa Y, Mayumi M
    Journal of Clinical Investigation 92(3) 1529-1533 1993
  • High carrier rate after hepatitis B virus infection in the elderly
    Kondo Y, Tsukada K, Takeuchi T, Mitsui T, Iwano K, Masuko K, Itoh T, Tokita H, Okamoto H, Tsuda F, Miyakawa Y, Mayumi M
    Hepatology 18(4) 768-774 1993
  • Imported hepatitis C virus genotypes in Japanese hemophiliacs [5]
    Kinoshita T, Miyake K, Okamoto H, Mishiro S
    Journal of Infectious Diseases 168(1) 249-250 1993
  • Predictive value of screening tests for persistent hepatitis C virus infection evidenced by viraemia
    Watanabe J, Matsumoto C, Fujimura K, Shimada T, Yoshizawa H, Okamoto H, Iizuka H, Tango T, Ikeda H, Endo N, Mazda T, Nojiri T, Aoyama K, Kanemitsu K, Yamano H, Mizui M, Yokoishi F, Tokunaga K, Nishioka K
    Vox Sanguinis 65(3) 199-203 1993
  • Prevalence, genotypes, and an isolate (HC-C2) of hepatitis C virus in chinese patients with liver disease
    Wang Y, Okamoto H, Tsuda F, Nagayama R, Tao Q.-M, Mishiro S
    Journal of Medical Virology 40(3) 254-260 1993
  • Recurrent fulminant hepatic failure in an HB carrier after intensive chemotherapy
    Yoshiba M, Sekiyama K, Iwabuchi S, Takatori M, Tanaka Y, Uchikoshi T, Okamoto H, Inoue K, Sugata F
    Digestive Diseases and Sciences 38(9) 1751-1755 1993
  • SDS-PAGe after micro-affinity adsorption for analysis of heterogeneous antigen polypeptides in individual sera
    Takahashi K, Kishimoto S, Ohori K, Yoshizawa H, Okamoto H, Miyakawa Y, Mayumi M
    Journal of Immunological Methods 157(1-2) 217-223 1993
  • Trans-complementation among naturally occurring deletion mutants of hepatitis B virus and integrated viral DNA for the production of viral particles with mutant genomes in hepatoma cell lines
    Okamoto H, Wang Y, Tanaka T, Machida A, Miyakawa Y, Mayumi M
    Journal of General Virology 74(3) 407-414 1993
  • Full-length nucleotide sequence of a Japanese hepatitis C virus isolate (HC-J1) with high homology to USA isolates.
    Okamoto H, Kanai N, Mishiro S
    Nucleic acids research 20 6410 Dec. 1992
  • Genetic drift of hepatitis C virus during an 8.2-year infection in a chimpanzee: variability and stability.
    Okamoto H, Kojima M, Okada S, Yoshizawa H, Iizuka H, Tanaka T, Muchmore EE, Peterson DA, Ito Y, Mishiro S
    Virology 190 894-899 Oct. 1992
  • Mutations within the S gene of hepatitis B virus transmitted from mothers to babies immunized with hepatitis B immune globulin and vaccine.
    Okamoto H, Yano K, Nozaki Y, Matsui A, Miyazaki H, Yamamoto K, Tsuda F, Machida A, Mishiro S
    Pediatric research 32 264-268 Sep. 1992
  • Fulminant hepatitis related to transmission of hepatitis B variants with precore mutations between spouses.
    Yotsumoto S, Kojima M, Shoji I, Yamamoto K, Okamoto H, Mishiro S
    Hepatology (Baltimore, Md.) 16 31-35 Jul. 1992
  • Full-length sequence of a hepatitis C virus genome having poor homology to reported isolates: comparative study of four distinct genotypes.
    Okamoto H, Kurai K, Okada S, Yamamoto K, Lizuka H, Tanaka T, Fukuda S, Tsuda F, Mishiro S
    Virology 188 331-341 May 1992
  • Typing hepatitis C virus by polymerase chain reaction with type-specific primers: application to clinical surveys and tracing infectious sources.
    Okamoto H, Sugiyama Y, Okada S, Kurai K, Akahane Y, Sugai Y, Tanaka T, Sato K, Tsuda F, Miyakawa Y
    The Journal of general virology 73 ( Pt 3) 673-679 Mar. 1992
  • Antibodies against synthetic oligopeptides deduced from the putative core gene for the diagnosis of hepatitis virus infection.
    Okamoto H, Tsuda F, Machida A, Munekata E, Akahane Y, Sugai Y, Mashiko K, Mitsui T, Tanaka T, Miyakawa Y
    Hepatology (Baltimore, Md.) 15 180-186 Feb. 1992
  • Activation of hepatitis C virus following immunosuppressive treatment [1]
    Yoshiba M, Sekiyama K, Sugata F, Kanamori H, Kodama F, Okamoto H
    Digestive Diseases and Sciences 37(3) 1992
  • Antibodies against synthetic oligopeptides deduced from the putative core gene for the diagnosis of hepatitis C virus infection
    Okamoto H, Tsuda F, Machida A, Munekata E, Akahane Y, Sugai Y, Mashiko K, Mitsui T, Tanaka T, Miyakawa Y, Mayumi M
    Hepatology 15(2) 180-186 1992
  • Correlation between Anti-HBc titers and HBV DNA in blood units without detectable HBsAg
    Iizuka H, Ohmura K, Ishijima A, Satoh K, Tanaka T, Tsuda F, Okamoto H, Miyakawa Y, Mayumi M
    Vox Sanguinis 63(2) 107-111 1992
  • Extraordinarily low density of hepatitis C virus estimated by sucrose density gradient centrifugation and the polymerase chain reaction
    Miyamoto H, Okamoto H, Sato K, Tanaka T, Mishiro S
    Journal of General Virology 73(3) 715-718 1992
  • Full-length nucleotide sequence of a Japanese hepatitis C virus isolate (HC-J1) with high homology to USA isolates
    Okamoto H, Kanai N, Mishiro S
    Nucleic Acids Research 20(23) 1992
  • Full-length sequence of a hepatitis C virus genome having poor homology to reported isolates: Comparative study of four distinct genotypes
    Okamoto H, Kurai K, Okada S.-I, Yamamoto K, Lizuka H, Tanaka T, Fukuda S, Tsuda F, Mishiro S
    Virology 188(1) 331-341 1992
  • Fulminant hepatitis related to transmission of hepatitis B variants with precore mutations between spouses
    Yotsumoto S, Kojima M, Shoji I, Yamamoto K, Okamoto H, Mishiro S
    Hepatology 16(1) 31-35 1992
  • Genetic drift of hepatitis C virus during an 8.2-year infection in a chimpanzee: Variability and stability
    Okamoto H, Kojima M, Okada S.-I, Yoshizawa H, Iizuka H, Tanaka T, Muchmore E.E, Peterson D.A, Ito Y, Mishiro S
    Virology 190(2) 894-899 1992
  • HCV genotypes in China [3]
    Wang Y, Okamoto H, Mishiro S
    Lancet 339(8802) 1992
  • HCV genotypes in chronic hepatitis C and response to interferon [16]
    Kanai K, Kako M, Okamoto H
    Lancet 339(8808) 1992
  • Hepatitis B surface antigen particles of subtypes adw and adr, and compound subtype (adwr) in symptom-free carriers in Japan
    Kanagawa H, Takai E, Tsuda F, Machida A, Kojima M, Ishijima A, Tanaka T, Okamoto H, Miyakawa Y, Mayumi M
    Journal of Medical Virology 37(4) 288-293 1992
  • Hepatitis C virus infection in medical personnel after needlestick accident
    Mitsui T, Iwano K, Masuko K, Yamazaki C, Okamoto H, Tsuda F, Tanaka T, Mishiro S
    Hepatology 16(5) 1109-1114 1992
  • Mutations within the S gene of hepatitis B virus transmitted from mothers to babies immunized with hepatitis B immune globulin and vaccine
    Okamoto H, Yano K, Nozaki Y, Matsui A, Miyazaki H, Yamamoto K, Tsuda F, Machida A, Mishiro S
    Pediatric Research 32(3) 264-268 1992
  • p26 Protein and 33-nm particle associated with nucleocapsid of hepatitis C virus recovered from the circulation of infected hosts
    Takahashi K, Kishimoto S, Yoshizawa H, Okamoto H, Yoshikawa A, Mishiro S
    Virology 191(1) 431-434 1992
  • Quantitative HCV RNA and effect of interferon therapy in chronic hepatitis C [1]
    Yamada G, Takahashi M, Tsuji T, Yoshizawa H, Okamoto H
    Digestive Diseases and Sciences 37(12) 1926-1927 1992
  • Reactivation of precore mutant hepatitis B virus leading to fulminant hepatic failure following cytotoxic treatment
    Yoshiba M, Sekiyama K, Sugata F, Okamoto H, Yamamoto K, Yotsumoto S
    Digestive Diseases and Sciences 37(8) 1253-1259 1992
  • Serodiagnosis of hepatitis C virus infection by ELISA for antibodies against the putative core protein (p20c) expressed in Escherichia coli
    Yoshikawa A, Takahashi K, Kishimoto S, Tsuda F, Akahane Y, Naito S, Tanaka T, Yoshizawa H, Yamasaki M, Okamoto H, Miyakawa Y, Mayumi M
    Journal of Immunological Methods 148(1-2) 143-150 1992
  • The degree of variability in the amino terminal region of the E2/NS1 protein of hepatitis C virus correlates with responsiveness to interferon therapy in viremic patients
    Okada S.-I, Akahane Y, Suzuki H, Okamoto H, Mishiro S
    Hepatology 16(3) 619-624 1992
  • Transmission of HCV between spouses [19]
    Akahane Y, Aikawa T, Sugai Y, Tsuda F, Okamoto H, Mishiro S
    Lancet 339(8800) 1059-1060 1992
  • Two distinct subtypes of hepatitis C virus defined by antibodies directed to the putative core protein
    Machida A, Ohnuma H, Tsuda F, Munekata E, Tanaka T, Akahane Y, Okamoto H, Mishiro S
    Hepatology 16(4) 886-891 1992
  • Typing hepatitis C virus by polymerase chain reaction with type-specific primers: Application to clinical surveys and tracing infectious sources
    Okamoto H, Sugiyama Y, Okada S, Kurai K, Akahane Y, Sugai Y, Tanaka T, Sato K, Tsuda F, Miyakawa Y, Mayumi M
    Journal of General Virology 73(3) 673-679 1992
  • Nucleotide sequence of the genomic RNA of hepatitis C virus isolated from a human carrier: comparison with reported isolates for conserved and divergent regions.
    Okamoto H, Okada S, Sugiyama Y, Kurai K, Iizuka H, Machida A, Miyakawa Y, Mayumi M
    The Journal of general virology 72 ( Pt 11) 2697-2704 Nov. 1991
  • Molecular epidemiology of hepatitis B virus in Indonesia.
    Sastrosoewignjo RI, Sandjaja B, Okamoto H
    Journal of gastroenterology and hepatology 6 491-498 Sep. 1991
  • Antiviral effect of interferon in patients with chronic hepatitis C who were treated with short term (4-6 weeks) interferon
    Akahane Y, Okada S, Miyazaki Y, Ainota T, Naito S, Zuzuki H, Sodeyama T, Nakano Y, Kiyosawa K, Furuta S, Tsuda F, Okamoto H
    Acta Hepatologica Japonica 32(3) 243-249 1991
  • Diagnosis of type C fulminant hepatitis by the detection of antibodies to the putative core proteins of hepatitis C virus
    Yoshiba M, Sekiyama K, Sugata F, Okamoto H
    Gastroenterologia Japonica 26(2) 1991
  • Fulminant hepatitis B: Induction by hepatitis B virus mutants defective in the precore region and incapable of encoding e antigen
    Kosaka Y, Takase K, Kojima M, Shimizu M, Inoue K, Yoshiba M, Tanaka S, Akahane Y, Okamoto H, Tsuda F, Miyakawa Y, Mayumi M
    Gastroenterology 100(4) 1087-1094 1991
  • HCV-RNA in type 2 autoimmune hepatitis [3]
    Miyakawa H, Kako M, Nagai K, Hino K, Iwabuchi S, Miyachi K, Okamoto H, Mayumi M
    American Journal of Gastroenterology 86(11) 1688-1689 1991
  • Hepatitis B virus mutants with precore-region defects in two babies with fulminant hepatitis and their mothers positive for antibody to hepatitis B e antigen
    Terazawa S, Kojima M, Yamanaka T, Yotsumoto S, Okamoto H, Tsuda F, Miyakawa Y, Mayumi M
    Pediatric Research 29(1) 5-9 1991
  • Molecular epidemiology of hepatitis B virus in Indonesia
    Sastrosoewignjo R.I, Sandjaja B, Okamoto H
    Journal of Gastroenterology and Hepatology 6(5) 491-498 1991
  • Nucleotide sequence of the genomic RNA of hepatitis C virus isolated from a human carrier: Comparison with reported isolates for conserved and divergent regions
    Okamoto H, Okada S, Sugiyama Y, Kurai K, Iizuka H, Machida A, Miyakawa Mayumi Y.M
    Journal of General Virology 72(11) 2697-2704 1991
  • Persistence of HCV replication in non-A, non-B fulminant viral hepatitis
    Yoshiba M, Sekiyama K, Sugata F, Okamoto H, Mayumi M
    Gastroenterologia Japonica 26(2) 1991
  • Point mutation in the precore region of HBV-DNA clones propagated from the sera of patients with fulminant type B hepatitis
    Shimizu M, Tokita H, Hoshiyama N, Takahashi Y, Kojima M, Okada S, Tsuda F, Sugiyama Y, Yotsumoto S, Okamoto H
    Acta Hepatologica Japonica 32(2) 141-146 1991
  • Posttransfusion fulminant hepatitis B associated with precore-defective HBV mutants
    Kojima M, Shimizu M, Tsuchimochi T, Koyasu M, Tanaka S, Iizuka H, Tanaka T, Okamoto H, Tsuda F, Miyakawa Y, Mayumi M
    Vox Sanguinis 60(1) 34-39 1991
  • Seroepidemiological survey of hepatitis C virus relative anti C100-3, anti CP-9, anti CP-10 and anti GOR antibodies in an endemic area for non-A, non-B hepatitis
    Tokita H, Shimizu M, Kojima M, Takahashi Y, Udo K, Tanaka T, Tsuda F, Okamoto H
    Acta Hepatologica Japonica 32(12) 1093-1100 1991
  • Similarity and diversity in sequence of HCV genome among Chinese, Japanese and American strains.
    Chen W.R, Okamoto H, Tao Q.M
    Chinese Medical Journal 104(10) 825-829 1991
  • Common and subtypic determinants of hepatitis B surface antigen particles: susceptibility to reduction and/or alkylation evaluated with monoclonal antibodies.
    Luengrojanakul P, Ohnuma H, Tachibana K, Usuda S, Okamoto H, Tanaka T, Tsuda F, Machida A, Mayumi M
    The Japanese journal of experimental medicine 60 253-261 Oct. 1990
  • Enzyme-linked immunosorbent assay for antibodies against the capsid protein of hepatitis C virus with a synthetic oligopeptide.
    Okamoto H, Munekata E, Tsuda F, Takahashi K, Yotsumoto S, Tanaka T, Tachibana K, Akahane Y, Sugai Y, Miyakawa Y
    The Japanese journal of experimental medicine 60 223-233 Aug. 1990
  • Detection of hepatitis C virus RNA by a two-stage polymerase chain reaction with two pairs of primers deduced from the 5'-noncoding region.
    Okamoto H, Okada S, Sugiyama Y, Tanaka T, Sugai Y, Akahane Y, Machida A, Mishiro S, Yoshizawa H, Miyakawa Y
    The Japanese journal of experimental medicine 60 215-222 Aug. 1990
  • Regulation of Na+,K(+)-ATPase. II. Cloning and analysis of the 5'-flanking region of the rat NKAB2 gene encoding the beta 2 subunit.
    Kawakami K, Okamoto H, Yagawa Y, Nagano K
    Gene 91 271-274 Jul. 1990
  • The 5'-terminal sequence of the hepatitis C virus genome.
    Okamoto H, Okada S, Sugiyama Y, Yotsumoto S, Tanaka T, Yoshizawa H, Tsuda F, Miyakawa Y, Mayumi M
    The Japanese journal of experimental medicine 60 167-177 Jun. 1990
  • Subtyping hepatitis B virus DNA in free or integrated forms by amplification of the S-gene sequences by the polymerase chain reaction and single-track sequencing for adenine.
    Yotsumoto S, Okamoto H, Tsuda F, Miyakawa Y, Mayumi M
    Journal of virological methods 28 107-116 May 1990
  • [Structure of hepatitis B virus and its related serological markers].
    Okamoto H
    Rinsho byori. The Japanese journal of clinical pathology 38 568-572 May 1990
  • Trans-complementation of the C gene of human and the P gene of woodchuck hepadnaviruses.
    Okamoto H, Omi S, Wang Y, Imai M, Mayumi M
    The Journal of general virology 71 ( Pt 4) 959-963 Apr. 1990
  • Hepatitis B viruses with precore region defects prevail in persistently infected hosts along with seroconversion to the antibody against e antigen.
    Okamoto H, Yotsumoto S, Akahane Y, Yamanaka T, Miyazaki Y, Sugai Y, Tsuda F, Tanaka T, Miyakawa Y, Mayumi M
    Journal of virology 64 1298-1303 Mar. 1990
  • [Clinical significance of hepatitis delta virus marker analysis].
    Yotsumoto S, Omi S, Okada S, Okamoto H
    Nihon rinsho. Japanese journal of clinical medicine 48 Suppl 304-308 Feb. 1990
  • Chronic active hepatitis with hepatitis B virus DNA and antibody against e antigen in the serum: Disturbed synthesis and secretion of e antigen from hepatocytes due to a point mutation in the precore region
    Akahane Y, Yamanaka T, Suzuki H, Sugai Y, Tsuda F, Yotsumoto Omi S.S, Okamoto H, Miyakawa Y, Mayumi M
    Gastroenterology 99(4) 1113-1119 1990
  • Clinical significance of hepatitis B virus marker analysis
    Yamanaka T, Yotsumoto S, Omi S, Okamoto H
    Nippon rinsho. Japanese journal of clinical medicine 48 Suppl 291-297 1990
  • Clinical significance of hepatitis delta virus marker analysis
    Yotsumoto S, Omi S, Okada S, Okamoto H
    Nippon rinsho. Japanese journal of clinical medicine 48 Suppl 304-308 1990
  • Common and subtypic determinants of hepatitis B surface antigen particles: Susceptibility to reduction and/or alkylation evaluated with monoclonal antibodies
    Luengrojanakul P, Ohnuma H, Tachibana K, Usuda S, Okamoto H, Tanaka T, Tsuda F, Machida A, Mayumi M
    Japanese Journal of Experimental Medicine 60(5) 253-261 1990
  • Defects in the precore region of hepatitis B virus DNA in a plasma pool from carriers seropositive for antibody against e antigen and with infectivity in chimpanzees
    Omi S, Okamoto H, Tsuda F, Mayumi M
    Journal of Gastroenterology and Hepatology 5(6) 646-652 1990
  • Defects in the precore region of the HBV genome in patients with chronic hepatitis B after sustained seroconversion from HBeAg to anti-HBe induced spontaneously or with interferon therapy
    Takeda K, Akahane Y, Suzuki H, Okamoto H, Tsuda F, Miyakawa Y, Mayumi M
    Hepatology 12(6) 1284-1289 1990
  • Detection of hepatitis C virus RNA by a two-stage polymerase chain reaction with two pairs of primers deduced from the 5'-noncoding region
    Okamoto H, Okada S, Sugiyama Y, Tanaka T, Sugai Y, Akahane Y, Machida A, Mishiro S, Yoshizawa H, Miyakawa Y, Mayumi M
    Japanese Journal of Experimental Medicine 60(4) 215-222 1990
  • Enzyme-linked immunosorbent assay for antibodies against the capsid protein of hepatitis C virus with a synthetic oligopeptide
    Okamoto H, Munekata E, Tsuda F, Takahashi K, Yotsumoto S, Tanaka T, Tachibana K, Akahane Y, Sugai Y, Miyakawa Y, Mayumi M
    Japanese Journal of Experimental Medicine 60(4) 223-232 1990
  • Hepatitis B viruses with precore region defects prevail in persistently infected hosts along with seroconversion to the antibody against e antigen
    Okamoto H, Yotsumoto S, Akahane Y, Yamanaka T, Miyazaki Y, Sugai Y, Tsuda F, Tanaka T, Miyakawa Y, Mayumi M
    Journal of Virology 64(3) 1298-1303 1990
  • Non-A, non-B hepatitis specific antibodies directed at host-derived epitope: Implication for an autoimmune process
    Mishiro S, Hoshi Y, Takeda K, Yoshikawa A, Gotanda T, Takahashi K, Akahane Y, Yoshizawa H, Okamoto H, Tsuda F, Peterson D.A, Muchmore E
    Lancet 336(8728) 1400-1403 1990
  • Structure of hepatitis B virus and its related serological markers
    Okamoto H
    Rinsho byori. The Japanese journal of clinical pathology 38(5) 568-572 1990
  • Subtyping hepatitis B virus DNA in free or integrated forms by amplification of the S-gene sequences by the polymerase chain reaction and single-track sequencing for adenine
    Yotsumoto S, Okamoto H, Tsuda F, Miyakawa Y, Mayumi M
    Journal of Virological Methods 28(2) 107-116 1990
  • Suppression of hepatitis C virus RNA by interferon-α
    Kanai K, Iwata K, Nakao K, Kako M, Okamoto H
    Lancet 336(8709) 1990
  • Synthetic oligopeptides bearing a common or subtypic determinant of hepatitis B surface antigen
    Ohnuma H, Takai E, Machida A, Tsuda F, Okamoto H, Tanaka T, Naito M, Munekata E, Miki K, Miyakawa Y, Mayumi M
    Journal of Immunology 145(7) 2265-2271 1990
  • The 5'-terminal sequence of the hepatitis C virus genome
    Okamoto H, Okada S, Sugiyama Y, Yotsumoto S, Tanaka T, Yo shizawa H, Tsuda F, Miyakawa Y, Mayumi M
    Japanese Journal of Experimental Medicine 60(3) 167-177 1990
  • Trans-complementation of the C gene of human and the P gene of woodchuck hepadnaviruses
    Okamoto H, Omi S, Wang Y, Imai M, Mayumi M
    Journal of General Virology 71(4) 959-963 1990
  • Fibrinogen Kyoto III: a congenital dysfibrinogen with a gamma aspartic acid-330 to tyrosine substitution manifesting impaired fibrin monomer polymerization.
    Terukina S, Yamazumi K, Okamoto K, Yamashita H, Ito Y, Matsuda M
    Blood 74 2681-2687 Dec. 1989
  • Quantitative and qualitative differences in serum HBV DNA between HBeAg positive carriers and those positive for anti-HBe.
    Okamoto H, Yotsumoto S, Tsuda F, Machida A, Mayumi M
    The Japanese journal of experimental medicine 59 259-262 Dec. 1989
  • The loss of subtypic determinants in alleles, d/y or w/r, on hepatitis B surface antigen.
    Okamoto H, Omi S, Wang Y, Itoh Y, Tsuda F, Tanaka T, Akahane Y, Miyakawa Y, Mayumi M
    Molecular immunology 26 197-205 Feb. 1989
  • Hepatitis B surface antigen with an excess or deficiency in subtypic determinants in sera from asymptomatic carriers in Japan
    Tachibana K, Tanaka T, Usuda S, Okamoto H, Tsuda F, Akahane Y, Miyakawa Y, Mayumi M
    Viral Immunology 2(1) 25-29 1989
  • Quantitative and qualitative differences in serum HVB DNA between HBeAg positive carriers and those positive for anti-HBe
    Okamoto H, Yotsumoto S, Tsuda F, Machida A, Mayumi M
    Japanese Journal of Experimental Medicine 59(6) 259-262 1989
  • State of hepatitis B virus DNA in peripheral blood mononuclear cells from persistently infected individuals: Correlation with e antigen and viral DNA in the serum as well as with the activity of liver disease
    Sugai Y, Okamoto H
    Tohoku Journal of Experimental Medicine 158(1) 73-84 1989
  • Typing hepatitis B virus by homology in nucleotide sequence: comparison of surface antigen subtypes.
    Okamoto H, Tsuda F, Sakugawa H, Sastrosoewignjo RI, Imai M, Miyakawa Y, Mayumi M
    The Journal of general virology 69 ( Pt 10) 2575-2583 Oct. 1988
  • Nucleotide sequence of a hepatitis B virus genome of subtype adw isolated from a Philippino: Comparison with the reported three genomes of the same subtype
    Estacio R.C, Chavez C.C, Okamoto H, Lingao A.L, Reyes M.T, Domingo E, Mayumi M
    Journal of Gastroenterology and Hepatology 3(3) 215-222 1988
  • Typing hepatitis B virus by homology in nucleotide sequence: Comparison of surface antigen subtypes
    Okamoto H, Tsuda F, Sakugawa H, Sastrosoewignjo R.I, Imai M, Miyakawa Y, Mayumi M
    Journal of General Virology 69(10) 2575-2583 1988
  • Free and integrated forms of hepatitis B virus DNA in human hepatocellular carcinoma cells (PLC/342) propagated in nude mice.
    Imai M, Hoshi Y, Okamoto H, Matsui T, Tsurimoto T, Matsubara K, Miyakawa Y, Mayumi M
    Journal of virology 61 3555-3560 Nov. 1987
  • Site-directed mutagenesis of hepatitis B surface antigen sequence at codon 160 from arginine to lysine for conversion of subtypic determinant from r to w.
    Okamoto H, Imai M, Miyakawa Y, Mayumi M
    Biochemical and biophysical research communications 148 500-504 Oct. 1987
  • Genomic heterogeneity of hepatitis B virus in a 54-year-old woman who contracted the infection through materno-fetal transmission.
    Okamoto H, Imai M, Kametani M, Nakamura T, Mayumi M
    The Japanese journal of experimental medicine 57 231-236 Aug. 1987
  • Defective mutants of hepatitis B virus in the circulation of symptom-free carriers.
    Okamoto H, Tsuda F, Mayumi M
    The Japanese journal of experimental medicine 57 217-221 Aug. 1987
  • Defective mutants of hepatitis B virus in the circulation of symptom-free carriers.
    Okamoto H, Tsuda F, Mayumi M
    Japanese Journal of Experimental Medicine 57(4) 217-221 1987
  • Free and integrated forms of hepatitis B virus DNA in human hepatocellular carcinoma cells (PLC/342) propagated in nude mice
    Imai M, Hoshi Y, Okamoto H, Matsui T, Tsurimoto T, Matsubara K, Miyakawa Y, Mayumi M
    Journal of Virology 61(11) 3555-3560 1987
  • Genomic heterogeneity of hepatitis B virus in a 54-year-old woman who contracted the infection through materno-fetal transmission.
    Okamoto H, Imai M, Kametani M, Nakamura T, Mayumi M
    Japanese Journal of Experimental Medicine 57(4) 231-236 1987
  • Point mutation in the S gene of hepatitis B virus for a d/y or w/r subtypic change in two blood donors carrying a surface antigen of compound subtype adyr or adwr
    Okamoto H, Imai M, Tsuda F, Tanaka T, Miyakawa Y, Mayumi M
    Journal of Virology 61(10) 3030-3034 1987
  • Site-directed mutagenesis of hepatitis B surface antigen sequence at codon 160 from arginine to lysine for conversion of subtypic determinant from r to w
    Okamoto H, Imai M, Miyakawa Y, Mayumi M
    Biochemical and Biophysical Research Communications 148(1) 500-504 1987
  • The complete nucleotide sequence of HBV DNA clone of subtype adw (pMND122) from Menado in Sulawesi Island, Indonesia
    Satrosoewignjo R.I, Omi S, Okamoto H, Mayumi M, Rustam M, Sujud
    ICMR Annals 7 51-60 1987
  • A solid-phase enzyme immunoassay for the common and subtypic determinants of hepatitis B surface antigen with monoclonal antibodies
    Usuda S, Tsuda F, Gotanda T, Tachibana K, Nomura M, Okamoto H, Imai M, Nakamura T, Miyakawa Y, Mayumi M
    Journal of Immunological Methods 87(2) 203-210 1986
  • Antibody to the receptor for polymerized human serum albumin in acute and persistent infection with hepatitis B virus
    Okamoto H, Usuda S, Imai M, Tachibana K, Tanaka E, Kumakura T, Itabashi M, Takai E, Tsuda F, Nakamura T
    Hepatology 6(3) 354-359 1986
  • Expression of the pre-S(2) gene of hepatitis B virus in Escherichia coli
    Tachibana K, Imai M, Okamoto H, Yoda K, Kadokura H, Katayama Y, Yamasaki M
    Biotechnology Letters 8(10) 677-682 1986
  • Nucleotide sequence of a cloned hepatitis B virus genome, subtype ayr: Comparison with genomes of the other three subtypes
    Okamoto H, Imai M, Shimozaki M, Hoshi Y, Iizuka H, Gotanda T, Tsuda F, Miyakawa Y, Mayumi M
    Journal of General Virology 67(11) 2305-2314 1986
  • Nude mice bearing human primary hepatocellular carcinoma that produces hepatitis B surface, core, and e antigens, as well as deoxyribonucleic acid polymerase
    Matsui T, Takano M, Miyamoto K, Itoh Y, Yoshizawa H, Koike M, Mochizuki T, Tanaka E, Okamoto H, Mai M, Mishiro S, Miyakawa Y, Mayumi M
    Gastroenterology 90(1) 135-142 1986
  • A two-site sandwich radioimmunoassay of human gamma interferon with monoclonal antibodies
    Tanaka E, Imai M, Usuda S, Tachibana K, Okamoto H, Ohike Y, Nakamura T, Miyakawa Y, Mayumi M
    Journal of Immunological Methods 77(2) 275-282 1985
  • Hemagglutination assay of polypeptide coded by the pre-S region of hepatitis B virus DNA with monoclonal antibody: Correlation of pre-S polypeptide with the receptor for polymerized human serum albumin in serums containing hepatitis B antigens
    Okamoto H, Imai M, Usuda S, Tanaka E, Tachibana K, Mishiro S, Machida A, Nakamura T, Miyakawa Y, Mayumi M
    Journal of Immunology 134(2) 1212-1216 1985
  • The complete nucleotide seqeunce of an HBV DNA clone of subtype adw (pRTB 299) from Indonesia
    Retno Iswari S, Okamoto H, Mayumi M
    ICMR Annals VOL. 5 39-50 1985
  • A two-site sandwich radioimmunoassay of β2-microglobulin with monoclonal antibodies
    Tachibana K, Tanaka E, Usuda S, Okamoto H, Imai M, Nakamura T, Miyakawa Y, Mayumi M
    Journal of Immunological Methods 75(1) 43-51 1984
  • Clinical Features of Hepatitis E Virus Infection in Ibaraki, Japan: Autochthonous Hepatitis E and Acute-on-Chronic Liver Failure
    Inagaki Yuki;Oshiro Yukio;Hasegawa Naoyuki;Fukuda Kuniaki;Abei Masato;Nishi Masaaki;Okamoto Hiroaki;Ohkohchi Nobuhiro
    Tohoku J. Exp. Med. 235(4) 275-282 2015
  • Serum Torque Teno Virus DNA Titer in Idiopathic Pulmonary Fibrosis Patients with Acute Respiratory Worsening
    Bando Masashi;Nakayama Masayuki;Takahashi Masaharu;Hosono Tatsuya;Mato Naoko;Yamasawa Hideaki;Okamoto Hiroaki;Sugiyama Yukihiko
    Japanese Journal of Medicine 54(9) 1015-1019 2015
  • Characteristics of 20 Patients with Autochthonous Acute Hepatitis E in Hokkaido, Japan: First Report of Bilateral Facial Palsy Following the Infection with Genotype 4 Hepatitis E Virus
    Yazaki Yasuyuki;Sugawara Kenji;Honda Mitsunori;Ohnishi Hiroshi;Nagashima Shigeo;Takahashi Masaharu;Okamoto Hiroaki
    Tohoku J. Exp. Med. 236(4) 263-271 2015
  • Clinical Features of Hepatitis E Virus Infection in Ibaraki, Japan: Autochthonous Hepatitis E and Acute-on-Chronic Liver Failure
    Inagaki Yuki;Oshiro Yukio;Hasegawa Naoyuki;Fukuda Kuniaki;Abei Masato;Nishi Masaaki;Okamoto Hiroaki;Ohkohchi Nobuhiro
    Tohoku J. Exp. Med. 235(4) 275-282 2015
  • Serum Torque Teno Virus DNA Titer in Idiopathic Pulmonary Fibrosis Patients with Acute Respiratory Worsening
    Bando Masashi;Nakayama Masayuki;Takahashi Masaharu;Hosono Tatsuya;Mato Naoko;Yamasawa Hideaki;Okamoto Hiroaki;Sugiyama Yukihiko
    Japanese Journal of Medicine 54(9) 1015-1019 2015
  • Characteristics of 20 Patients with Autochthonous Acute Hepatitis E in Hokkaido, Japan: First Report of Bilateral Facial Palsy Following the Infection with Genotype 4 Hepatitis E Virus
    Yazaki Yasuyuki;Sugawara Kenji;Honda Mitsunori;Ohnishi Hiroshi;Nagashima Shigeo;Takahashi Masaharu;Okamoto Hiroaki
    Tohoku J. Exp. Med. 236(4) 263-271 2015
  • Clinical Features of Hepatitis E Virus Infection in Ibaraki, Japan: Autochthonous Hepatitis E and Acute-on-Chronic Liver Failure
    Inagaki Yuki;Oshiro Yukio;Hasegawa Naoyuki;Fukuda Kuniaki;Abei Masato;Nishi Masaaki;Okamoto Hiroaki;Ohkohchi Nobuhiro
    Tohoku J. Exp. Med. 235(4) 275-282 2015
  • Serum Torque Teno Virus DNA Titer in Idiopathic Pulmonary Fibrosis Patients with Acute Respiratory Worsening
    Bando Masashi;Nakayama Masayuki;Takahashi Masaharu;Hosono Tatsuya;Mato Naoko;Yamasawa Hideaki;Okamoto Hiroaki;Sugiyama Yukihiko
    Japanese Journal of Medicine 54(9) 1015-1019 2015
  • Characteristics of 20 Patients with Autochthonous Acute Hepatitis E in Hokkaido, Japan: First Report of Bilateral Facial Palsy Following the Infection with Genotype 4 Hepatitis E Virus
    Yazaki Yasuyuki;Sugawara Kenji;Honda Mitsunori;Ohnishi Hiroshi;Nagashima Shigeo;Takahashi Masaharu;Okamoto Hiroaki
    Tohoku J. Exp. Med. 236(4) 263-271 2015
  • Clinical Features of Hepatitis E Virus Infection in Ibaraki, Japan: Autochthonous Hepatitis E and Acute-on-Chronic Liver Failure
    Inagaki Yuki;Oshiro Yukio;Hasegawa Naoyuki;Fukuda Kuniaki;Abei Masato;Nishi Masaaki;Okamoto Hiroaki;Ohkohchi Nobuhiro
    Tohoku J. Exp. Med. 235(4) 275-282 2015
  • Serum Torque Teno Virus DNA Titer in Idiopathic Pulmonary Fibrosis Patients with Acute Respiratory Worsening
    Bando Masashi;Nakayama Masayuki;Takahashi Masaharu;Hosono Tatsuya;Mato Naoko;Yamasawa Hideaki;Okamoto Hiroaki;Sugiyama Yukihiko
    Japanese Journal of Medicine 54(9) 1015-1019 2015
  • Characteristics of 20 Patients with Autochthonous Acute Hepatitis E in Hokkaido, Japan: First Report of Bilateral Facial Palsy Following the Infection with Genotype 4 Hepatitis E Virus
    Yazaki Yasuyuki;Sugawara Kenji;Honda Mitsunori;Ohnishi Hiroshi;Nagashima Shigeo;Takahashi Masaharu;Okamoto Hiroaki
    Tohoku J. Exp. Med. 236(4) 263-271 2015
  • Clinical Features of Hepatitis E Virus Infection in Ibaraki, Japan: Autochthonous Hepatitis E and Acute-on-Chronic Liver Failure
    Inagaki Yuki;Oshiro Yukio;Hasegawa Naoyuki;Fukuda Kuniaki;Abei Masato;Nishi Masaaki;Okamoto Hiroaki;Ohkohchi Nobuhiro
    Tohoku J. Exp. Med. 235(4) 275-282 2015
  • Serum Torque Teno Virus DNA Titer in Idiopathic Pulmonary Fibrosis Patients with Acute Respiratory Worsening
    Bando Masashi;Nakayama Masayuki;Takahashi Masaharu;Hosono Tatsuya;Mato Naoko;Yamasawa Hideaki;Okamoto Hiroaki;Sugiyama Yukihiko
    Japanese Journal of Medicine 54(9) 1015-1019 2015
  • Characteristics of 20 Patients with Autochthonous Acute Hepatitis E in Hokkaido, Japan: First Report of Bilateral Facial Palsy Following the Infection with Genotype 4 Hepatitis E Virus
    Yazaki Yasuyuki;Sugawara Kenji;Honda Mitsunori;Ohnishi Hiroshi;Nagashima Shigeo;Takahashi Masaharu;Okamoto Hiroaki
    Tohoku J. Exp. Med. 236(4) 263-271 2015
  • Production of monoclonal antibodies against the ORF3 protein of rat hepatitis E virus (HEV) and demonstration of the incorporation of the ORF3 protein into enveloped rat HEV particles
    Masaharu Takahashi, Tominari Kobayashi, Tanggis, Suljid Jirintai, Mulyanto, Shigeo Nagashima, Tsutomu Nishizawa, Satoshi Kunita, Hiroaki Okamoto
    Archives of Virology Dec. 2016
  • Analysis of adaptive mutations selected during the consecutive passages of hepatitis E virus produced from an infectious cDNA clone
    Shigeo Nagashima, Tominari Kobayashi, Toshinori Tanaka, Tanggis, Suljid Jirintai, Masaharu Takahashi, Tsutomu Nishizawa, Hiroaki Okamoto
    Virus Research 223 170 Sep. 2016
  • Clinical Features of Hepatitis E Virus Infection in Ibaraki, Japan: Autochthonous Hepatitis E and Acute-on-Chronic Liver Failure
    Inagaki Yuki;Oshiro Yukio;Hasegawa Naoyuki;Fukuda Kuniaki;Abei Masato;Nishi Masaaki;Okamoto Hiroaki;Ohkohchi Nobuhiro
    Tohoku J. Exp. Med. 235(4) 275-282 2015
  • Serum Torque Teno Virus DNA Titer in Idiopathic Pulmonary Fibrosis Patients with Acute Respiratory Worsening
    Bando Masashi;Nakayama Masayuki;Takahashi Masaharu;Hosono Tatsuya;Mato Naoko;Yamasawa Hideaki;Okamoto Hiroaki;Sugiyama Yukihiko
    Japanese Journal of Medicine 54(9) 1015-1019 2015
  • Age group-dependent distribution of hepatitis C virus (HCV) serogroup and assumed transmission route in HCV-infected patients in a hospital in the Mito area
    Aikawa Tatsuya;Ueno Chisato;Kikuchi Yohko;Tsuda Fumio;Okamoto Hiroaki
    Kanzo 56(6) 303-305 2015
  • Characteristics of 20 Patients with Autochthonous Acute Hepatitis E in Hokkaido, Japan: First Report of Bilateral Facial Palsy Following the Infection with Genotype 4 Hepatitis E Virus
    Yazaki Yasuyuki;Sugawara Kenji;Honda Mitsunori;Ohnishi Hiroshi;Nagashima Shigeo;Takahashi Masaharu;Okamoto Hiroaki
    Tohoku J. Exp. Med. 236(4) 263-271 2015
  • Two cases of acute hepatitis E infected with descendant strains of hepatitis E virus genotype 3 strain isolated from swine herd in Miyazaki Prefecture 12 years ago -one case had acute facial paralysis-
    NAKAMURA Masahiko;KUSUMOTO Kazunori;OCHIAI Toshimasa;KAWAGOE Tomio;TAI Hiroshi;MATSUOKA Hitoshi;NAKANO Tatsunori;NAGATA Kenji;SHIMODA Kazuya;OKAMOTO Hiroaki
    Nippon Shokakibyo Gakkai Zasshi 112(8) 1533-1541 2015
  • Direct-acting antiviral agent-resistant mutants in patients with type C chronic liver diseases: Detection and its clinical significance
    Aikawa Tatsuya;Ueno Chisato;Kikuchi Yohko;Tsuda Fumio;Ohnishi Hiroshi;Okamoto Hiroaki
    Kanzo 56(11) 621-624 2015
  • Two cases of acute hepatitis E in the same geographical area infected with different viral strains
    Morita Susumu;Yoshizawa Kaname;Uchiyama Natsuki;Fujimori Kazuya;Shigeno Takashi;Okamoto Hiroaki
    Kanzo 56(11) 625-627 2015
  • Metachronous occurrence of two cases of acute hepatitis E after eating raw pig liver and heart at the same restaurant at Gifu city in Japan
    Shimizu Shogo;Sugihara Junichi;Suzuki Yusuke;Nishigaki Yoichi;Takahashi Masaharu;Takahashi Kazuaki;Nakano Tatsunori;Hayashi Hideki;Kato Tomohiro;Tomita Eiichi;Arai Masahiro;Okamoto Hiroaki
    Kanzo 56(11) 617-620 2015
  • Two cases of sporadic acute hepatitis E in Mie, Japan who were infected with subgenotype 1a hepatitis E virus
    Okano Hiroshi;Maekawa Tadashi;Kobayashi Makoto;Yamawaki Makoto;Ninomiya Jun;Nakano Tatsunori;Uraki Satoko;Tanaka Hideaki;Shiraki Katsuya;Takei Yoshiyuki;Takahashi Masaharu;Okamoto Hiroaki
    Kanzo 57(2) 81-88 2016
  • Clinical Features of Hepatitis E Virus Infection in Ibaraki, Japan: Autochthonous Hepatitis E and Acute-on-Chronic Liver Failure
    Inagaki Yuki;Oshiro Yukio;Hasegawa Naoyuki;Fukuda Kuniaki;Abei Masato;Nishi Masaaki;Okamoto Hiroaki;Ohkohchi Nobuhiro
    Tohoku J. Exp. Med. 235(4) 275-282 2015
  • Serum Torque Teno Virus DNA Titer in Idiopathic Pulmonary Fibrosis Patients with Acute Respiratory Worsening
    Bando Masashi;Nakayama Masayuki;Takahashi Masaharu;Hosono Tatsuya;Mato Naoko;Yamasawa Hideaki;Okamoto Hiroaki;Sugiyama Yukihiko
    Japanese Journal of Medicine 54(9) 1015-1019 2015
  • Age group-dependent distribution of hepatitis C virus (HCV) serogroup and assumed transmission route in HCV-infected patients in a hospital in the Mito area
    Aikawa Tatsuya;Ueno Chisato;Kikuchi Yohko;Tsuda Fumio;Okamoto Hiroaki
    Kanzo 56(6) 303-305 2015
  • Characteristics of 20 Patients with Autochthonous Acute Hepatitis E in Hokkaido, Japan: First Report of Bilateral Facial Palsy Following the Infection with Genotype 4 Hepatitis E Virus
    Yazaki Yasuyuki;Sugawara Kenji;Honda Mitsunori;Ohnishi Hiroshi;Nagashima Shigeo;Takahashi Masaharu;Okamoto Hiroaki
    Tohoku J. Exp. Med. 236(4) 263-271 2015
  • Two cases of acute hepatitis E infected with descendant strains of hepatitis E virus genotype 3 strain isolated from swine herd in Miyazaki Prefecture 12 years ago -one case had acute facial paralysis-
    NAKAMURA Masahiko;KUSUMOTO Kazunori;OCHIAI Toshimasa;KAWAGOE Tomio;TAI Hiroshi;MATSUOKA Hitoshi;NAKANO Tatsunori;NAGATA Kenji;SHIMODA Kazuya;OKAMOTO Hiroaki
    Nippon Shokakibyo Gakkai Zasshi 112(8) 1533-1541 2015
  • Direct-acting antiviral agent-resistant mutants in patients with type C chronic liver diseases: Detection and its clinical significance
    Aikawa Tatsuya;Ueno Chisato;Kikuchi Yohko;Tsuda Fumio;Ohnishi Hiroshi;Okamoto Hiroaki
    Kanzo 56(11) 621-624 2015
  • Two cases of acute hepatitis E in the same geographical area infected with different viral strains
    Morita Susumu;Yoshizawa Kaname;Uchiyama Natsuki;Fujimori Kazuya;Shigeno Takashi;Okamoto Hiroaki
    Kanzo 56(11) 625-627 2015
  • Metachronous occurrence of two cases of acute hepatitis E after eating raw pig liver and heart at the same restaurant at Gifu city in Japan
    Shimizu Shogo;Sugihara Junichi;Suzuki Yusuke;Nishigaki Yoichi;Takahashi Masaharu;Takahashi Kazuaki;Nakano Tatsunori;Hayashi Hideki;Kato Tomohiro;Tomita Eiichi;Arai Masahiro;Okamoto Hiroaki
    Kanzo 56(11) 617-620 2015
  • Two cases of sporadic acute hepatitis E in Mie, Japan who were infected with subgenotype 1a hepatitis E virus
    Okano Hiroshi;Maekawa Tadashi;Kobayashi Makoto;Yamawaki Makoto;Ninomiya Jun;Nakano Tatsunori;Uraki Satoko;Tanaka Hideaki;Shiraki Katsuya;Takei Yoshiyuki;Takahashi Masaharu;Okamoto Hiroaki
    Kanzo 57(2) 81-88 2016
  • Clinical Features of Hepatitis E Virus Infection in Ibaraki, Japan: Autochthonous Hepatitis E and Acute-on-Chronic Liver Failure
    Inagaki Yuki;Oshiro Yukio;Hasegawa Naoyuki;Fukuda Kuniaki;Abei Masato;Nishi Masaaki;Okamoto Hiroaki;Ohkohchi Nobuhiro
    Tohoku J. Exp. Med. 235(4) 275-282 2015
  • Serum Torque Teno Virus DNA Titer in Idiopathic Pulmonary Fibrosis Patients with Acute Respiratory Worsening
    Bando Masashi;Nakayama Masayuki;Takahashi Masaharu;Hosono Tatsuya;Mato Naoko;Yamasawa Hideaki;Okamoto Hiroaki;Sugiyama Yukihiko
    Japanese Journal of Medicine 54(9) 1015-1019 2015
  • Age group-dependent distribution of hepatitis C virus (HCV) serogroup and assumed transmission route in HCV-infected patients in a hospital in the Mito area
    Aikawa Tatsuya;Ueno Chisato;Kikuchi Yohko;Tsuda Fumio;Okamoto Hiroaki
    Kanzo 56(6) 303-305 2015
  • Characteristics of 20 Patients with Autochthonous Acute Hepatitis E in Hokkaido, Japan: First Report of Bilateral Facial Palsy Following the Infection with Genotype 4 Hepatitis E Virus
    Yazaki Yasuyuki;Sugawara Kenji;Honda Mitsunori;Ohnishi Hiroshi;Nagashima Shigeo;Takahashi Masaharu;Okamoto Hiroaki
    Tohoku J. Exp. Med. 236(4) 263-271 2015
  • Two cases of acute hepatitis E infected with descendant strains of hepatitis E virus genotype 3 strain isolated from swine herd in Miyazaki Prefecture 12 years ago -one case had acute facial paralysis-
    NAKAMURA Masahiko;KUSUMOTO Kazunori;OCHIAI Toshimasa;KAWAGOE Tomio;TAI Hiroshi;MATSUOKA Hitoshi;NAKANO Tatsunori;NAGATA Kenji;SHIMODA Kazuya;OKAMOTO Hiroaki
    Nippon Shokakibyo Gakkai Zasshi 112(8) 1533-1541 2015
  • Direct-acting antiviral agent-resistant mutants in patients with type C chronic liver diseases: Detection and its clinical significance
    Aikawa Tatsuya;Ueno Chisato;Kikuchi Yohko;Tsuda Fumio;Ohnishi Hiroshi;Okamoto Hiroaki
    Kanzo 56(11) 621-624 2015
  • Two cases of acute hepatitis E in the same geographical area infected with different viral strains
    Morita Susumu;Yoshizawa Kaname;Uchiyama Natsuki;Fujimori Kazuya;Shigeno Takashi;Okamoto Hiroaki
    Kanzo 56(11) 625-627 2015
  • Metachronous occurrence of two cases of acute hepatitis E after eating raw pig liver and heart at the same restaurant at Gifu city in Japan
    Shimizu Shogo;Sugihara Junichi;Suzuki Yusuke;Nishigaki Yoichi;Takahashi Masaharu;Takahashi Kazuaki;Nakano Tatsunori;Hayashi Hideki;Kato Tomohiro;Tomita Eiichi;Arai Masahiro;Okamoto Hiroaki
    Kanzo 56(11) 617-620 2015
  • Two cases of sporadic acute hepatitis E in Mie, Japan who were infected with subgenotype 1a hepatitis E virus
    Okano Hiroshi;Maekawa Tadashi;Kobayashi Makoto;Yamawaki Makoto;Ninomiya Jun;Nakano Tatsunori;Uraki Satoko;Tanaka Hideaki;Shiraki Katsuya;Takei Yoshiyuki;Takahashi Masaharu;Okamoto Hiroaki
    Kanzo 57(2) 81-88 2016
  • Clinical Features of Hepatitis E Virus Infection in Ibaraki, Japan: Autochthonous Hepatitis E and Acute-on-Chronic Liver Failure
    Inagaki Yuki;Oshiro Yukio;Hasegawa Naoyuki;Fukuda Kuniaki;Abei Masato;Nishi Masaaki;Okamoto Hiroaki;Ohkohchi Nobuhiro
    Tohoku J. Exp. Med. 235(4) 275-282 2015
  • Serum Torque Teno Virus DNA Titer in Idiopathic Pulmonary Fibrosis Patients with Acute Respiratory Worsening
    Bando Masashi;Nakayama Masayuki;Takahashi Masaharu;Hosono Tatsuya;Mato Naoko;Yamasawa Hideaki;Okamoto Hiroaki;Sugiyama Yukihiko
    Japanese Journal of Medicine 54(9) 1015-1019 2015
  • Age group-dependent distribution of hepatitis C virus (HCV) serogroup and assumed transmission route in HCV-infected patients in a hospital in the Mito area
    Aikawa Tatsuya;Ueno Chisato;Kikuchi Yohko;Tsuda Fumio;Okamoto Hiroaki
    Kanzo 56(6) 303-305 2015
  • Characteristics of 20 Patients with Autochthonous Acute Hepatitis E in Hokkaido, Japan: First Report of Bilateral Facial Palsy Following the Infection with Genotype 4 Hepatitis E Virus
    Yazaki Yasuyuki;Sugawara Kenji;Honda Mitsunori;Ohnishi Hiroshi;Nagashima Shigeo;Takahashi Masaharu;Okamoto Hiroaki
    Tohoku J. Exp. Med. 236(4) 263-271 2015
  • Two cases of acute hepatitis E infected with descendant strains of hepatitis E virus genotype 3 strain isolated from swine herd in Miyazaki Prefecture 12 years ago -one case had acute facial paralysis-
    NAKAMURA Masahiko;KUSUMOTO Kazunori;OCHIAI Toshimasa;KAWAGOE Tomio;TAI Hiroshi;MATSUOKA Hitoshi;NAKANO Tatsunori;NAGATA Kenji;SHIMODA Kazuya;OKAMOTO Hiroaki
    Nippon Shokakibyo Gakkai Zasshi 112(8) 1533-1541 2015
  • Direct-acting antiviral agent-resistant mutants in patients with type C chronic liver diseases: Detection and its clinical significance
    Aikawa Tatsuya;Ueno Chisato;Kikuchi Yohko;Tsuda Fumio;Ohnishi Hiroshi;Okamoto Hiroaki
    Kanzo 56(11) 621-624 2015
  • Two cases of acute hepatitis E in the same geographical area infected with different viral strains
    Morita Susumu;Yoshizawa Kaname;Uchiyama Natsuki;Fujimori Kazuya;Shigeno Takashi;Okamoto Hiroaki
    Kanzo 56(11) 625-627 2015
  • Metachronous occurrence of two cases of acute hepatitis E after eating raw pig liver and heart at the same restaurant at Gifu city in Japan
    Shimizu Shogo;Sugihara Junichi;Suzuki Yusuke;Nishigaki Yoichi;Takahashi Masaharu;Takahashi Kazuaki;Nakano Tatsunori;Hayashi Hideki;Kato Tomohiro;Tomita Eiichi;Arai Masahiro;Okamoto Hiroaki
    Kanzo 56(11) 617-620 2015
  • Two cases of sporadic acute hepatitis E in Mie, Japan who were infected with subgenotype 1a hepatitis E virus
    Okano Hiroshi;Maekawa Tadashi;Kobayashi Makoto;Yamawaki Makoto;Ninomiya Jun;Nakano Tatsunori;Uraki Satoko;Tanaka Hideaki;Shiraki Katsuya;Takei Yoshiyuki;Takahashi Masaharu;Okamoto Hiroaki
    Kanzo 57(2) 81-88 2016

Papers(other)

  • 群馬県におけるE型肝炎の最近2年間の発生状況
    山崎勇一, 竹内卓, 上野敬史, 畑中健, 橋爪洋明, 滝澤大地, 長沼篤, 堀口昇男, 佐藤賢, 柿崎暁, 高山尚, 高木均, 岡本宏明
    日本消化器病学会雑誌 110 A824 Sep. 2013
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    肝臓 54(Supplement 2) A553 Sep. 2013
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    犬山シンポジウム記録集 29th 23-28 Jun. 2013
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    永坂敦, 梅村真知子, 青木敬則, 姜貞憲, 高木秀雄, 後藤哲, 水尾仁志, 吉田行範, 髭修平, 狩野吉康, 佐賀啓良, 新井雅裕, 高橋和明, 三代俊治, 岡本宏明
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  • 遺伝子型4new Sapporo strainによるE型急性肝炎の臨床像と重症化因子
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    肝臓 54(Supplement 1) A246 Apr. 2013
  • ブタ由来E型肝炎ウイルス(HEV)のラットへの感染実験~E型肝炎ワクチン開発に向けて~
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    肝臓 54(Supplement 1) A381 Apr. 2013
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    肝臓 54(Supplement 1) A28 Apr. 2013
  • わが国の肝移植患者におけるE型肝炎の感染状況と慢性化の実態調査~第1次全国アンケート調査報告~
    田野井智倫, 大城幸雄, 岡本宏明, 大河内信弘
    肝臓 54(Supplement 1) A247 Apr. 2013
  • 当院における経口感染ウイルス性肝炎(A型,E型)症例の検討
    岡野宏, 松崎晋平, 佐瀬友博, 齋藤知規, 向克巳, 西村晃, 長嶋茂雄, 高橋雅春, 岡本宏明
    日本消化器病学会雑誌 110 A422 Feb. 2013
  • 輸血によるウイルス感染の更なる減少を目指して
    岡本宏明
    血液事業 35(4) 683-684 Feb. 2013
Display all
Papers(other)close
  • 群馬県におけるE型肝炎の最近2年間の発生状況
    山崎勇一, 竹内卓, 上野敬史, 畑中健, 橋爪洋明, 滝澤大地, 長沼篤, 堀口昇男, 佐藤賢, 柿崎暁, 高山尚, 高木均, 岡本宏明
    日本消化器病学会雑誌 110 A824 Sep. 2013
  • 岡山県内狩猟者の「E型肝炎」の認識調査
    川上万里, 高橋雅春, 岡本宏明, 足立卓哉, 藤岡真一, 大澤俊哉, 糸島達也
    肝臓 54(Supplement 2) A553 Sep. 2013
  • B型急性肝炎および慢性肝疾患におけるHBVゲノタイプAの頻度と感染経路の検討
    鈴木一幸, 滝川康裕, 遠藤龍人, 宮坂昭生, 宮本康弘, 小野寺美緒, 小山富子, 岡本宏明, 伊藤清顕, 溝上雅史
    犬山シンポジウム記録集 29th 23-28 Jun. 2013
  • 2011年暮れから札幌圏で発生したE型肝炎小流行の検討
    永坂敦, 梅村真知子, 青木敬則, 姜貞憲, 高木秀雄, 後藤哲, 水尾仁志, 吉田行範, 髭修平, 狩野吉康, 佐賀啓良, 新井雅裕, 高橋和明, 三代俊治, 岡本宏明
    肝臓 54(Supplement 1) A381 Apr. 2013
  • 遺伝子型4new Sapporo strainによるE型急性肝炎の臨床像と重症化因子
    姜貞憲, 狩野吉康, 水尾仁志, 高橋和明, 新井雅裕, 岡本宏明
    肝臓 54(Supplement 1) A246 Apr. 2013
  • ブタ由来E型肝炎ウイルス(HEV)のラットへの感染実験~E型肝炎ワクチン開発に向けて~
    田野井智倫, 大城幸雄, 服部眞次, 竹内薫, 永田恭介, 安江博, 岡本宏明, 大河内信弘
    肝臓 54(Supplement 1) A381 Apr. 2013
  • 薬物性肝障害診断スコアリングにおけるE型肝炎の診断マーカー追加の必要性についての検討
    岡野宏, 中野達徳, 岡本宏明
    肝臓 54(Supplement 1) A28 Apr. 2013
  • わが国の肝移植患者におけるE型肝炎の感染状況と慢性化の実態調査~第1次全国アンケート調査報告~
    田野井智倫, 大城幸雄, 岡本宏明, 大河内信弘
    肝臓 54(Supplement 1) A247 Apr. 2013
  • 当院における経口感染ウイルス性肝炎(A型,E型)症例の検討
    岡野宏, 松崎晋平, 佐瀬友博, 齋藤知規, 向克巳, 西村晃, 長嶋茂雄, 高橋雅春, 岡本宏明
    日本消化器病学会雑誌 110 A422 Feb. 2013
  • 輸血によるウイルス感染の更なる減少を目指して
    岡本宏明
    血液事業 35(4) 683-684 Feb. 2013
  • 抗ウイルス療法の現状と今後の展望 各論 抗肝炎ウイルス薬 A型肝炎,E型肝炎
    岡本宏明
    臨床と微生物 40(1) 057-063 Jan. 2013
  • Transmission of genotype A (A2) hepatitis B virus from patients who developed acute hepatitis B to their sexual partners, via interspousal or homosexual infection
    Aikawa Tatsuya, Tsuda Fumio, Ueno Chisato, Mamiya Takashi, Sugiyama Hiroaki, Soeda Atsuko, Ikezawa Kazuto, Nagashima Shigeo, Takahashi Masaharu, Okamoto Hiroaki
    Kanzo 54(6) 373-380 2013
  • B型肝炎ウイルスe抗体陽性無症候性キャリアの長期予後に関する検討 B型肝炎ウイルスe抗体陽性無症候性キャリアとその再活性化に関わるB型肝炎ウイルス因子の解明―HBVのin vitro実験系の構築とその予備的検討―
    岡本宏明, 西澤勉
    B型肝炎ウイルスe抗体陽性無症候性キャリアの長期予後に関する検討 平成24年度 総括・分担研究報告書 58-59 2013
  • Two cases with imported hepatitis A who were presumed to have contracted the disease while visiting Indonesia based on molecular analysis of hepatitis A virus strains
    KOBATA Tatsuro, TATSUMI Ryoji, TAKEMOTO Takahiro, TANAKA Toshiki, HIRATA Kuniaki, SEKIOKA Toshio, TAKEDA Soro, ISHIKANE Masahiro, YOKOTA Kazuhisa, NATORI Yoichirou, IKEYA Takashi, FURUKAWA Keiichi, KAWAKAMI Manri, TAKAHASHI Masaharu, OKAMOTO Hiroaki
    Kanzo 53(11) 754-762 Nov. 2012
  • E型肝炎の現状と今後の戦略
    岡本宏明
    週刊日本医事新報(4621) 71-77 Nov. 2012
  • E型肝炎ウイルスについての最近の知見
    岡本宏明
    日本ウイルス学会学術集会プログラム・抄録集 60th 111 Oct. 2012
  • 培養細胞から放出されたE型肝炎ウイルスの粒子表面に存在する膜成分の抗原性の解析
    長嶋茂雄, 高橋雅春, 吉林台, 西澤勉, 小林富成, 岡本宏明
    日本ウイルス学会学術集会プログラム・抄録集 60th 409 Oct. 2012
  • A Japanese girl infected with natural inter-genotypic (2b/1b) recombinant of hepatitis C virus had a favorable response to PEG-IFN/RBV combination therapy
    YOKOYAMA Koji, KUMAGAI Hideki, KIMURA Takehito, YOTSUMOTO Shigeru, OKAMOTO Hiroaki, MOMOI Mariko Y.
    26(1) 5-11 Sep. 2012
  • 輸血によるウイルス感染の更なる減少を目指して
    岡本宏明
    血液事業 35(2) 365 Aug. 2012
  • 新規に保険収載された検査法「IgA‐HE抗体価(定性)」
    岡本宏明
    モダンメディア 58(6) 182-187 Jun. 2012
  • E型肝炎ウイルス感染の現状と対策
    岡本宏明
    血液事業 35(1) 228-229 May 2012
  • 遺伝子解析にて夫婦間感染と判明した高齢者B型C型急性肝炎の背景と問題点
    中山晴夫, 岡本宏明
    肝臓 53(Supplement 1) A350 Apr. 2012
  • ウイルス肝炎のすべて II 経口感染するウイルス肝炎 2.E型肝炎(4)E型肝炎ウイルス培養系
    岡本宏明
    化学療法の領域 28 1022-1031 Apr. 2012
  • 同一感染源によると思われる家族内発症E型急性肝炎の2例
    渡邊俊司, 礒田憲夫, 廣澤拓也, 東澤俊彦, 新井由季, 佐藤隆, 菅野健太郎, 岡本宏明
    肝臓 53(Supplement 1) A462 Apr. 2012
  • 経口肝炎ウイルス:最近の知見
    岡本宏明
    日本輸血細胞治療学会誌 58(2) 180-181 Apr. 2012
  • A case of hepatitis E differentially diagnosed from drug-induced liver injury
    ISHIWATA Sho, TAKAGI Hitoshi, HOSHINO Takashi, NAGANUMA Atsushi, SAKAMOTO Naomi, KOITABASHI Eri, SOUMA Hiromitsu, INUI Masayuki, KUDO Tomohiro, OGAWA Akira, TAHARA Hiroki, KANEKO Mieko, OKAMOTO Hiroaki
    Nippon Shokakibyo Gakkai Zasshi 109(4) 624-629 Apr. 2012
  • 経口感染する肝炎ウイルス(A型,E型)の感染防止,遺伝的多様性,および治療に関する研究 分子進化学を駆使した日本土着genotype 3 HEVの起源,日本への侵入時期,感染拡大の歴史と今後の感染拡大防止策の提案
    中野達徳, 三代俊治, 高橋和明, 新井雅裕, 岡本宏明, 橋本直明
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  • 経口感染する肝炎ウイルス(A型,E型)の感染防止,遺伝的多様性,および治療に関する研究 種の壁を越えたHEVの培養細胞での増殖
    高橋雅春, 岡本宏明, 田中利典, 吉林台, 高橋秀行
    経口感染する肝炎ウイルス(A型、E型)の感染防止、遺伝的多様性、および治療に関する研究 平成23年度 総括・分担研究報告書 60-62 2012
  • 経口感染する肝炎ウイルス(A型,E型)の感染防止,遺伝的多様性,および治療に関する研究 平成21年度~平成23年度
    岡本宏明
    経口感染する肝炎ウイルス(A型、E型)の感染防止、遺伝的多様性、および治療に関する研究 平成21-23年度 総合研究報告書 72P 2012
  • 経口感染する肝炎ウイルス(A型,E型)の感染防止,遺伝的多様性,および治療に関する研究 HEVの感染細胞からの放出に関わる宿主因子
    長嶋茂雄, 岡本宏明
    経口感染する肝炎ウイルス(A型、E型)の感染防止、遺伝的多様性、および治療に関する研究 平成23年度 総括・分担研究報告書 63-65 2012
  • 経口感染する肝炎ウイルス(A型,E型)の感染防止,遺伝的多様性,および治療に関する研究
    岡本宏明
    経口感染する肝炎ウイルス(A型、E型)の感染防止、遺伝的多様性、および治療に関する研究 平成23年度 総括・分担研究報告書 1-16 2012
  • 経口感染する肝炎ウイルス(A型,E型)の感染防止,遺伝的多様性,および治療に関する研究 北海道E型肝炎研究会による北海道内HEV感染実態の研究
    姜貞憲, 狩野吉康, 水尾仁志, 松居剛志, 新井雅裕, 岡本宏明
    経口感染する肝炎ウイルス(A型、E型)の感染防止、遺伝的多様性、および治療に関する研究 平成23年度 総括・分担研究報告書 46-48 2012
  • 「免疫抑制薬,抗悪性腫瘍薬によるB型肝炎ウイルス再活性化の実態解明と対策法の確立」B型劇症肝炎の解析
    井戸章雄, 岡本宏明, 桶谷真, 宇都浩文, 森内昭博, 玉井努, 熊谷公太郎, 馬渡誠一
    免疫抑制薬,抗悪性腫瘍薬によるB型肝炎ウイルス再活性化の実態解明と対策法の確立 平成23年度 研究成果報告書 37-42 2012
  • A case of hepatitis E differentially diagnosed from drug-induced liver injury
    ISHIWATA SHO, TAKAGI HITOSHI, HOSHINO TAKASHI, NAGANUMA ATSUSHI, SAKAMOTO NAOMI, KOITABASHI ERI, SOUMA HIROMITSU, INUI MASAYUKI, KUDO TOMOHIRO, OGAWA AKIRA, TAHARA HIROKI, KANEKO MIEKO, OKAMOTO HIROAKI
    日本消化器病学会雑誌 109(4) 624-629 (J-STAGE) 2012
  • Epidemiological survey of hepatitis E virus infection in Kushiro and Nemuro cities in eastern Hokkaido : relationship between regional difference of HEV prevalence and distinct food cultures
    TANABE Toshio, MIZUO Hitoshi, YAZAKI Yasuyuki, TAKAHASHI Masaharu, OKAMOTO Hiroaki
    Kanzo 52(9) 567-574 Sep. 2011
  • E型肝炎ウイルス感染の現状と対策
    岡本宏明
    血液事業 34(2) 319 Aug. 2011
  • E型肝炎 E型肝炎ウイルスのウイルス学的特徴
    岡本宏明
    日本臨床 69 579-587 May 2011
  • Virological characteristics of hepatitis E virus
    Japanese journal of clinical medicine 69(0) 579-587 May 2011
  • 急性肝障害におけるE型肝炎の実態と岩手県における疫学調査
    熊谷一郎, 宮坂昭生, 阿部弘一, 小山富子, 滝川康裕, 鈴木一幸, 岡本宏明
    肝臓 52(Supplement 1) A111 Apr. 2011
  • 北海道におけるHEV感染の実態
    姜貞憲, 水尾仁志, 狩野吉康, 岡本宏明, 三代俊治
    肝臓 52(Supplement 1) A110 Apr. 2011
  • 当院におけるE型肝炎13例の臨床的,ウイルス学的検討
    渡邊俊司, 礒田憲夫, 廣澤拓也, 津久井舞未子, 大竹俊哉, 佐藤慎, 東澤俊彦, 長嶺伸彦, 菅野健太郎, 岡本宏明
    肝臓 52(Supplement 1) A111 Apr. 2011
  • 母体感染症up to date B/C型以外のウイルス性肝炎
    横山孝二, 岡本宏明
    周産期医学 41(2) 225-229 Feb. 2011
  • 肝炎診療の新たな展開 E型肝炎の現況
    岡本宏明
    綜合臨床 60(1) 95-101 Jan. 2011
  • Current status of hepatitis E
    60(1) 95-101 Jan. 2011
  • 経口感染する肝炎ウイルス(A型,E型)の感染防止,遺伝的多様性,および治療に関する研究 HEVの放出機構の解析
    長嶋茂雄, 岡本宏明
    経口感染する肝炎ウイルス(A型、E型)の感染防止、遺伝的多様性、および治療に関する研究 平成22年度 総括・分担研究報告書 49-51 2011
  • 経口感染する肝炎ウイルス(A型,E型)の感染防止,遺伝的多様性,および治療に関する研究
    岡本宏明
    経口感染する肝炎ウイルス(A型、E型)の感染防止、遺伝的多様性、および治療に関する研究 平成22年度 総括・分担研究報告書 1-6 2011
  • 経口感染する肝炎ウイルス(A型,E型)の感染防止,遺伝的多様性,および治療に関する研究 野生イノシシから分離された新規HEV株の解析
    高橋雅春, 岡本宏明
    経口感染する肝炎ウイルス(A型、E型)の感染防止、遺伝的多様性、および治療に関する研究 平成22年度 総括・分担研究報告書 43-45 2011
  • 経口感染する肝炎ウイルス(A型,E型)の感染防止,遺伝的多様性,および治療に関する研究 北海道E型肝炎研究会によるHEV感染実態の研究
    姜貞憲, 狩野吉康, 水尾仁志, 松居剛志, 小関至, 小川浩司, 梅村真知子, 新井雅裕, 岡本宏明, 松林圭二
    経口感染する肝炎ウイルス(A型、E型)の感染防止、遺伝的多様性、および治療に関する研究 平成22年度 総括・分担研究報告書 22-25 2011
  • 難治性の肝・胆道疾患に関する調査研究 感染培養系を用いた劇症E型肝炎ウイルス株の解析
    岡本宏明, 高橋雅春, 長嶋茂雄, 田中利典, 吉林台, 西澤勉, 井上淳
    難治性の肝・胆道疾患に関する調査研究 平成22年度 総括・分担研究報告書 137-138 2011
  • 難治性の肝・胆道疾患に関する調査研究 劇症肝炎に関する研究
    坪内博仁, 持田智, 國土典宏, 上本伸二, 藤澤知雄, 鈴木一幸, 市田隆文, 横須賀収, 福井博, 竹原徹郎, 岡本宏明, 森脇久隆, 汐田剛史, 坂井田功, 井上和明, 前原喜彦
    難治性の肝・胆道疾患に関する調査研究 平成20-22年度 総合研究報告書 21-23 2011
  • 薬物性肝障害との鑑別を要したE型肝炎の1例
    石綿翔, 高木均, 小板橋絵里, 星野崇, 坂本直美, 相馬宏光, 長沼篤, 工藤智洋, 岡本宏明
    国立病院総合医学会講演抄録集 65th 425 2011
  • E型肝炎ウイルスのORF3蛋白質に認められるPSAPモチーフのウイルス放出における機能解析
    長嶋茂雄, 高橋雅春, 田中利典, 吉林台, 西澤勉, 岡本宏明
    日本ウイルス学会学術集会プログラム・抄録集 58th 314 Oct. 2010
  • TTV(Torque teno virus)による急性肝炎が考えられた2症例
    井上元子, 横山孝二, 池田尚広, 中村幸恵, 熊谷秀規, 四元茂, 岡本宏明, 桃井眞里子
    日本小児科学会雑誌 114(10) 1620 Oct. 2010
  • 感染症 ウイルス性肝炎 E型肝炎
    高橋雅春, 岡本宏明
    日本臨床 31-37 Sep. 2010
  • 感染症 ウイルス性肝炎 TTV(トークテノウイルス)
    岡本宏明
    日本臨床 47-53 Sep. 2010
  • 感染症 ウイルス性肝炎 アデノウイルス肝炎
    岡本宏明
    日本臨床 54-58 Sep. 2010
  • E型肝炎をめぐって―診断法と感染培養系の確立と基礎・臨床への応用―
    岡本宏明
    Minophagen Med Rev 55(3) 207-218 Sep. 2010
  • ウイルス肝炎 ウイルス肝炎の疫学 3 E型肝炎ウイルス感染
    岡本宏明
    治療学 44(9) 974-977 Sep. 2010
  • 免疫学的検査 E.感染症関連検査(抗原および抗体を含む)ウイルス感染症 TTV(トークテノウイルス)
    岡本宏明
    日本臨床 68 465-468 Jun. 2010
  • Cell culture system for hepatitis E virus
    OKAMOTO Hiroaki
    Virus 60(1) 93-104 Jun. 2010
  • TTV (torque teno virus)
    Japanese journal of clinical medicine 68(0) 465-468 Jun. 2010
  • “Kitami/Abashiristrain”の近縁株による札幌圏内E型肝炎小流行
    小関至, 姜貞憲, 狩野吉康, 赤池淳, 大村卓味, 松居剛志, 佐賀啓良, 代田充, 水尾仁志, 渡辺正夫, 三浦洋輔, 倉敏郎, 常松泉, 松林圭二, 池田久實, 岡本宏明, 高橋和明, 安倍夏生, 新井雅裕, 三代俊治
    肝臓 51(Supplement 1) A216 Apr. 2010
  • E型肝炎ウイルスの感染性cDNAクローンの確立と増殖機構解明への応用
    山田健太郎, 高橋雅春, 星野悠, 高橋秀行, 市山浩二, 長嶋茂雄, 田中利典, 岡本宏明
    自治医科大学紀要 32 138-139 Mar. 2010
  • 経口感染する肝炎ウイルス(A型,E型)の感染防止,遺伝的多様性,および治療に関する研究 E型肝炎ウイルス(HEV)感染実態の全国調査と血中HEVを用いた培養系の検討
    岡本宏明, 高橋雅春, 田中利典, 長嶋茂雄
    経口感染する肝炎ウイルス(A型、E型)の感染防止、遺伝的多様性、および治療に関する研究 平成21年度 総括研究報告書 40-44 2010
  • 経口感染する肝炎ウイルス(A型,E型)の感染防止,遺伝的多様性,および治療に関する研究 北海道E型肝炎研究会による道内HEV感染実態の究明と2009年札幌圏E型肝炎小流行の解析
    姜貞憲, 狩野吉康, 水尾仁志, 松居剛志, 小関至, 新井雅裕, 岡本宏明, 松林圭二
    経口感染する肝炎ウイルス(A型、E型)の感染防止、遺伝的多様性、および治療に関する研究 平成21年度 総括研究報告書 36-39 2010
  • 医師からみたズーノーシス~飼い主・動物医療従事者の感染予防のために~第12回 E型肝炎 医師からみたE型肝炎
    岡本宏明
    SA Med 11(5) 76-81 Oct. 2009
  • E型肝炎ウイルスの感染培養系
    岡本宏明
    日本ウイルス学会学術集会プログラム・抄録集 57th 121 Oct. 2009
  • E型肝炎ウイルスの感染性cDNAを用いた培養馴化株の遺伝子変異の解析
    長嶋茂雄, 田中利典, 高橋雅春, 吉林台, 岡本宏明
    日本ウイルス学会学術集会プログラム・抄録集 57th 395 Oct. 2009
  • Present status of hepatitis E in Japan
    OKAMOTO Hiroaki
    37(4) 345-354 Sep. 2009
  • Development of serological and molecular diagnostic methods for hepatitis D and molecular epidemiological studies on hepatitis D virus infection
    TAKAHASHI Masaharu, OKAMOTO Hiroaki, TSATSRALT-OD Bira, AIKAWA Tatsuya
    37(4) 329-336 Sep. 2009
  • 肝炎 わが国におけるE型肝炎の現状
    岡本宏明
    臨床とウイルス 37(4) 345-354 Sep. 2009
  • 肝炎 D型肝炎の診断法の確立と分子疫学的研究の成果
    高橋雅春, 岡本宏明, TSATSRALT‐OD Bira, 相川達也
    臨床とウイルス 37(4) 329-336 Sep. 2009
  • 三重県津・鈴鹿地区における急性E型肝炎の発生についての検討
    岡野宏, 松崎晋平, 佐瀬友博, 斎藤知規, 向克巳, 西村晃, 伊藤圭一, 白木克哉, 竹井謙之, 岡本宏明
    日本消化器病学会雑誌 106 A903 Sep. 2009
  • 当院で経験したE型肝炎の臨床的,ウイルス学的検討
    福島寛美, 廣澤拓也, 津久井舞未子, 大竹俊哉, 佐藤慎, 東澤俊彦, 長嶺伸彦, 礒田憲夫, 菅野健太郎, 岡本宏明
    肝臓 50(Supplement 2) A544 Sep. 2009
  • 肝疾患診療の新しい展開 E型肝炎の現状とワクチン開発
    岡本宏明
    日本医師会雑誌 138(6) 1095-1099 Sep. 2009
  • Present status of hepatitis E and development of hepatitis E vaccine
    The Journal of the Japan Medical Association 138(6) 1095-1099 Sep. 2009
  • 過去10年間における宮城県のE型肝炎の発生状況
    井上淳, 上野義之, 長崎太, 赤羽武弘, 福島耕治, 近藤泰輝, 嘉数英二, 玉井恵一, 城戸治, 中込悠, 二宮匡史, 小原範之, 涌井祐太, 岡本宏明, 下瀬川徹
    肝臓 50(Supplement 1) A218 Apr. 2009
  • Genotype Hの急性B型肝炎の1例と本邦における感染報告例の検討
    馬場英, 古家乾, 中川絹子, 葛西健二, 定岡邦昌, 山口勇雄, 佐藤進一郎, 岡本宏明
    日本消化器病学会雑誌 106 A363 Mar. 2009
  • 注意すべきウイルス感染症 人獣共通感染症としてのE型肝炎―感染防御の視点から
    岡本宏明
    診断と治療 97(3) 594-599 Mar. 2009
  • 肝炎ウイルスの分子医学的研究とその応用
    岡本宏明
    モダンメディア 55(2) 28-35 Feb. 2009
  • Recent advances in hepatitis E : including the development and application of a robust cell culture system for HEV
    OKAMOTO Hiroaki
    Nippon Shokakibyo Gakkai Zasshi 106(2) 177-187 Feb. 2009
  • E型肝炎の感染経路・宿主域・遺伝的多様性・感染防止・診断・治療に関する研究 日本のヒトと動物から採取されるE型肝炎ウイルス株の解析
    三代俊治, 高橋和明, 安倍夏生, 橋本みちえ, アクバル SMF, 加藤孝宣, 新井雅裕, 岡本宏明, 川上万里, 佐久川廣, 持田智, 松田裕之, 杉之下与志樹, 渡邊精四郎, 山本和秀, 谷口美幸, 金守良, 川村欣也, 北嶋直人, 森宏光, 大西幸代, 井上和明
    E型肝炎の感染経路・宿主域・遺伝的多様性・感染防止・診断・治療に関する研究 平成20年度 総括研究報告書 36-40 2009
  • Recent advances in hepatitis E: including the development and application of a robust cell culture system for HEV
    OKAMOTO HIROAKI
    日本消化器病学会雑誌 106(2) 177-187 (J-STAGE) 2009
  • E型肝炎の感染経路・宿主域・遺伝的多様性・感染防止・診断・治療に関する研究 E型肝炎ウイルスの感染培養系を用いた基礎研究
    岡本宏明
    E型肝炎の感染経路・宿主域・遺伝的多様性・感染防止・診断・治療に関する研究 平成20年度 総括研究報告書 41-43 2009
  • E型肝炎の感染経路・宿主域・遺伝的多様性・感染防止・診断・治療に関する研究 北海道におけるE型急性肝炎症例発生数の推移―道E研集積例の解析―
    姜貞憲, 狩野吉康, 水尾仁志, 松居剛志, 三代俊治, 岡本宏明, 松林圭二
    E型肝炎の感染経路・宿主域・遺伝的多様性・感染防止・診断・治療に関する研究 平成20年度 総括研究報告書 30-32 2009
  • 肝細胞癌を合併したWilson病の一症例
    水尾仁志, 古山準一, 本城信吾, 森園竜太郎, 代田充, 内沢政英, 高木秀雄, 田辺利男, 佐々木豊, 岡本宏明
    日本門脈圧こう進症学会雑誌 14(1) 81 Oct. 2008
  • 群馬県におけるE型肝炎
    長沼篤, 高草木智史, 竝川昌司, 湯浅和久, 萩原聡, 大塚敏之, 柳澤正敏, 下山康之, 市川武, 柿崎暁, 佐藤賢, 高木均, 岡本宏明
    肝臓 49(Supplement 3) A732 Oct. 2008
  • Genotype4のE型肝炎ウイルスの全長塩基配列の解析による劇症化に関連する塩基の同定
    井上淳, 上野義之, 岡本宏明
    肝臓 49(Supplement 2) A509 Sep. 2008
  • MHC固定デュロックブタに関する免疫生物学的研究.4.豚丹毒ワクチン接種およびE型肝炎ウイルス感染抗体価
    OK Kar Soe, 北川均, 安藤麻子, 今枝紀明, 大場恵典, 吉岡豪, 牛島稔大, 岡本宏明, 田中穂積, 小林英司
    日本獣医学会学術集会講演要旨集 146th 185 Sep. 2008
  • 3Rsに沿った実験用ブタ施設運営への取り組み
    田中穂積, 今野兼次郎, 菱川修司, LEFOR Alan, 岡本宏明, 小林英司
    日本獣医学会学術集会講演要旨集 146th 305 Sep. 2008
  • E型肝炎ウイルス研究の進歩
    岡本宏明
    肝臓 49(Supplement 2) A419 Sep. 2008
  • SLAハプロタイプ固定近交系デュロックブタにおける抗体産生
    安藤麻子, 今枝紀明, 吉岡豪, 岡本宏明, 田中穂積, 河田寿子, 重成敦子, 小林英司, 猪子英俊, 北川均
    MHC 15(2) 186 Aug. 2008
  • 札幌市内3医療機関に於ける最近10年間の急性E型肝炎の変遷
    水尾仁志, 姜貞憲, 狩野吉康, 本城信吾, 松居剛志, 荒川智宏, 岡本宏明, 三代俊治
    肝臓 49(Supplement 1) A155 Apr. 2008
  • 上部消化管内視鏡によるC型肝炎ウイルスの患者対患者感染の可能性に関する分子生物学的研究
    戸田崇之, 榎原毅, 増子和郎, 三井健宏, 岡本宏明
    日本衛生学雑誌 63(2) 388 Mar. 2008
  • E型肝炎の感染経路・宿主域・遺伝的多様性・感染防止・診断・治療に関する研究 E型肝炎ウイルスの感染培養系
    岡本宏明
    E型肝炎の感染経路・宿主域・遺伝的多様性・感染防止・診断・治療に関する研究 平成19年度 総括研究報告書 27-28 2008
  • E型肝炎の感染経路・宿主域・遺伝的多様性・感染防止・診断・治療に関する研究 北海道におけるE型急性肝炎の臨床像とHEV伝搬経路
    姜貞憲, 狩野吉康, 水尾仁志, 前久保博士, 松居剛志, 三代俊治, 岡本宏明
    E型肝炎の感染経路・宿主域・遺伝的多様性・感染防止・診断・治療に関する研究 平成19年度 総括研究報告書 46-48 2008
  • 当院で経験した急性E型肝炎の2症例
    岡野宏, 西村晃, 村田一素, 岡本宏明
    肝臓 48(Supplement 3) A649 Nov. 2007
  • A型肝炎における遺伝子型の検索と疫学的,臨床的検討
    俵章夫, 若宮稔, 嶋崎亮一, 青木いづみ, 進藤浩子, 坂本穣, 岡田俊一, 榎本信幸, 岡本宏明, 赤羽賢浩
    肝臓 48(Supplement 1) A261 Apr. 2007
  • 非B非C肝細胞癌の臨床病理学的特徴
    小山寛一, 増子和郎, 岡本宏明, 真弓忠, 津田文男
    日本外科学会雑誌 108 607 Mar. 2007
  • E型肝炎の感染経路・宿主域・遺伝的多様性・感染防止・診断・治療に関する研究 HEVの培養系の確立とその応用
    岡本宏明
    E型肝炎の感染経路・宿主域・遺伝的多様性・感染防止・診断・治療に関する研究 平成18年度 総括研究報告書 25-26 2007
  • B型肝炎ワクチン療法により,母子感染による肝炎発症を阻止しえている1例(Nested‐PCR法を用いた解析の有用性)
    四元茂, 市川万邦, 桃谷孝之, 岡本宏明, 三浦琢磨, 菊池豊
    日本小児科学会雑誌 110(11) 1594 Nov. 2006
  • Prevalences of antibodies to hepatitis E virus (HEV) and HEV RNA among blood donors with an elevated ALT of .GEQ.61IU/L in Tochigi, Japan
    FUKUDA SATOKO, ISHIKAWA MAMI, OCHIAI NAOMI, SUZUKI YUKO, SUNAGA JUNKO, SHINOHARA NOBUKATSU, SAITO NOBUO, TAKAHASHI MASAHARU, OKAMOTO HIROAKI, TSUDA FUMIO
    血液事業 29(3) 425-431 Nov. 2006
  • 埼玉県の肝機能異常献血者におけるHEV感染の実態及びviremiaの同定
    五反田裕子, 岩田明子, 伊藤由理, 中島清美, 立花克己, 大沼均, 吉川昭, 溝口秀昭, 岡本宏明
    血液事業 29(2) 276 Aug. 2006
  • The forefront of medicine and therapy. The present status of condition of hepatitis E.
    OKAMOTO HIROAKI
    日本内科学会雑誌 95(5) 945-951 May 2006
  • 急性E型肝炎の重症化に関わる諸因子の検討
    熊谷一郎, 宮坂昭生, 妻神重彦, 佐藤彰宏, 遠藤龍人, 阿部弘一, 滝川康裕, 鈴木一幸, 岡本宏明
    肝臓 47(Supplement 1) A167 Apr. 2006
  • E型肝炎―最新の知見 E型肝炎ウイルスの基礎(3)E型肝炎ウイルス感染の血清学的診断
    岡本宏明
    臨床消化器内科 21(5) 569-577 Apr. 2006
  • E型肝炎―最新の知見 人獣共通感染症としてのE型肝炎(1)ブタにおけるE型肝炎ウイルス感染
    高橋雅春, 岡本宏明
    臨床消化器内科 21(5) 579-586 Apr. 2006
  • Genotype classification of hepatitis viruses and its significance.
    OKAMOTO HIROAKI
    血液事業 28(4) 539-541 Feb. 2006
  • Research on diagnosis, prevention, and epidemiology of hepatitis E in Japan. Molecular virological study of infection with hepatitis E virus.
    OKAMOTO HIROAKI
    本邦に於けるE型肝炎の診断・予防・疫学に関する研究 平成17年度 総括研究報告書 44-46 2006
  • Comparison of the Prevalence of Hepatitis A and E Virus Infections among Patients infected with Human Immunodeficiency Virus Type 1 in Japan
    SHIBAYAMA T, MASUDA G, AJISAWA A, GOTANDA Y, YOSHIKAWA A, MIZOGUCHI H, OKAMOTO H, TSUDA F
    Kanzo 46(11) 663-664 Nov. 2005
  • ヒト,ブタ,イノシシにおけるE型肝炎ウイルスの感染状況
    川本歩, 田中真弓, 黒川ちひろ, 金田聡子, 奥田浩, 岡本宏明
    鳥取県衛生環境研究所報(45) 1-3 Sep. 2005
  • 本邦におけるE型肝炎の実態 HEV抗体を用いたE型肝炎の血清疫学的検討
    坂本穣, 俵章夫, 内藤成子, 岡田俊一, 榎本信幸, 依田芳起, 赤羽賢浩, 岡本宏明
    月刊消化器科 41(2) 168-172 Aug. 2005
  • 急性E型肝炎と豚レバー・ホルモン摂取との関連性,その重症化の要因についての検討
    水尾仁志, 岡沢林太郎, 古山準一, 草間敬司, 森園竜太郎, 本城信吾, 内沢政英, 矢崎康幸, 岡本宏明
    日本公衆衛生学会総会抄録集 64th 922 Aug. 2005
  • 肝炎ウイルスの遺伝子型分類とその意義
    岡本宏明
    血液事業 28(2) 208 Aug. 2005
  • 栃木県内のALT高値(≧61IU/L)献血者におけるHEV感染
    石川真美, 落合直美, 鈴木祐子, 須永純子, 福田さと子, 篠原信勝, 斎藤信雄, 津田文男, 岡本宏明
    血液事業 28(2) 317 Aug. 2005
  • The severe form of hepatitis E in Japan
    KUMAGAI ICHIRO, KASAI YUKIHO, MIYASAKA AKIO, TSUMAGAMI SHIGEHIKO, ENDO TATSUHITO, ABE HIROKAZU, TAKIKAWA HIROYASU, SUZUKI KAZUYUKI, OKAMOTO HIROAKI
    肝胆膵 51(1) 61-67 Jul. 2005
  • E型肝炎ウイルスについての最近の話題
    岡本宏明
    週刊日本医事新報(4236) 17-20 Jul. 2005
  • C型肝炎ウイルス抗体陽性者におけるE型肝炎ウイルス抗体陽性者率の検討
    楠元寿典, 宇都浩文, 黒木穣二, 坂元秀壮, 蓮池悟, 永田賢治, 林克裕, 落合俊雅, 岡本宏明
    肝臓 46(Supplement 1) A220 May 2005
  • これだけは知っておきたい国際感染症 各論 国内にある感染症 E型肝炎
    岡本宏明
    モダンフィジシャン 25(5) 557-561 May 2005
  • E型急性肝炎の血清診断におけるIgAクラス抗HEV抗体測定用試薬「イムニスIgA anti‐HEV EIA」の有用性の検討
    飯野四郎, 狩野吉康, 前久保博士, KANG Jong‐Hon, 三代俊治, 新井雅裕, 北嶋直人, 市田隆文, 岡本宏明
    月刊医学と薬学 53(4) 461-469 Apr. 2005
  • 肝炎ウイルス研究のニューフロンティア
    岡本宏明
    日本消化器病学会雑誌 102 A14 Mar. 2005
  • 原因不明の肝炎,肝硬変,肝癌の病態 原因不明の急性肝炎におけるE型肝炎の意義とその臨床学的特徴
    長崎太, 上野義之, 下瀬川徹, 岡本宏明
    月刊消化器科 40(2) 188-193 Feb. 2005
  • Genotype of hepatitis virus. 5. Hepatitis E virus.
    OKAMOTO Hiroaki
    Kanzo 46(8) 491-497 2005
  • 1. Round-table discussion on usefulness and future perspectives of the genotype research
    Mishiro Shunji, Mizokami Masashi, Okamoto Hiroaki, Sakugawa Hiroshi, Tanaka Yasuhito, Yano Koji
    Kanzo 46(8) 454-473 2005
  • Viral disease. E-type hepatitis virus as a new cause virus of amphixenosis.
    OKAMOTO HIROAKI
    現代医療 36(11) 2211-2216 Nov. 2004
  • 北海道におけるE型肝炎:zoonotic food‐borne transmissionの意義
    水尾仁志, 古山準一, 岡本宏明
    日本消化器病学会雑誌 101 A508 Sep. 2004
  • 当科におけるE型急性肝炎7例の検討
    菅原謙二, 矢崎康幸, 岡本宏明
    肝臓 45(Supplement 2) A381 Sep. 2004
  • 当科におけるE型急性肝炎7例の検討
    菅原謙二, 矢崎康幸, 岡本宏明
    日本消化器病学会雑誌 101 A507 Sep. 2004
  • 肝機能検査値の一過性上昇と断酒を契機にC型肝炎ウイルスが消失したC型肝炎ウイルスキャリアの1例
    時田元, 多賀谷健, 福井秀雄, 田中晃久, 上司裕史, 矢倉道泰, 原田英治, 岡本宏明
    肝臓 45(Supplement 2) A470 Sep. 2004
  • 北海道におけるE型肝炎:zoonotic food‐borne transmissionの意義
    水尾仁志, 古山準一, 岡本宏明
    肝臓 45(Supplement 2) A382 Sep. 2004
  • ウイルスと肝炎―新しい知見と治療への取り組み―肝炎ウイルスの分子ウイルス学
    岡本宏明
    最新医学 59(9) 1859-1868 Sep. 2004
  • VI.TTV(トークテノウイルス)TTVの分子生物学
    岡本宏明
    日本臨床 62 557-565 Aug. 2004
  • V.E型肝炎ウイルス(HEV)人畜共通感染症としてのE型肝炎
    岡本宏明
    日本臨床 62 524-531 Aug. 2004
  • II.B型肝炎ウイルス(HBV)B型ウイルス肝炎の分子免疫学 HBs抗体エスケープ変異株―感染防御上および診断上の問題点―
    岡本宏明
    日本臨床 62 98-105 Aug. 2004
  • E型肝炎
    岡本宏明
    臨床医 30(8) 1658-1661 Aug. 2004
  • 医学実験に用いる家畜豚とミニ豚でのE型肝炎ウイルス感染
    田中穂積, 岡本宏明, 小林英司
    日本獣医学会学術集会講演要旨集 138th 207 Aug. 2004
  • I.C型肝炎ウイルス(HCV)HCV遺伝子全塩基配列の解析による遺伝子型分類
    時田元, 岡本宏明
    日本臨床 62 70-75 Jul. 2004
  • 急性E型肝炎の診断における,HEVのORF2領域(4型)の蛋白を抗原としたELISA法の有用性について
    水尾仁志, 杉沢憲, 古山準一, 草間敬司, 高橋麦, 高木秀雄, 宮崎慎一, 岡和田敦, 岡本宏明
    肝臓 45(Supplement 1) A272 Apr. 2004
  • C型慢性肝炎に対するインターフェロン単独治療による完全著効例における肝細胞癌発症の危険因子の検討
    時田元, 多賀谷健, 福井秀雄, 田中晃久, 上司裕史, 矢倉道泰, 原田英治, 岡本宏明
    肝臓 45(Supplement 1) A239 Apr. 2004
  • 原因不明の急性肝炎におけるE型肝炎の意義とその臨時的特徴
    長崎太, 上野義之, 岡本宏明
    日本消化器病学会雑誌 101 A86 Mar. 2004
  • ウイルス肝炎―新たな治療法《ウイルス肝炎の自然経過と治療指針》E型肝炎ウイルス感染症
    岡本宏明
    内科 93(3) 430-434 Mar. 2004
  • 肺癌合併特発性肺線維症におけるTTウイルス(TTV)の関与について
    坂東政司, 大野彰二, 岡本宏明, 杉山幸比古
    日本内科学会雑誌 93 134 Feb. 2004
  • Development of genome classification method for TT-virus and its application to clarify the clinical features of its infection.
    OKAMOTO HIROAKI
    TTウイルスの遺伝子型分類法の開発と感染病態解明への応用 平成13-15年度 No.13357003 236P 2004
  • ヒトと野生動物―E型肝炎について―
    岡本宏明
    日本比較臨床医学会講演要旨集 35th 15-16 2004
  • 声の広場 家畜豚の実験使用によるE型肝炎ウイルス対策
    田中穂積, 吉野浩之, 若井拓哉, 袴田陽二, 椎貝正太, 長尾慶和, 岡本宏明, 小林英司
    Organ Biol 10(4) 339-347 Dec. 2003
  • Fulminant hepatitis E in Japan
    SUZUKI KAZUYUKI, ABE HIROKAZU, KUMAGAI ICHIRO, ENDO TATSUHITO, TAKIGAWA YASUHIRO, OKAMOTO HIROAKI
    肝胆膵 47(5) 665-670 Nov. 2003
  • Virological diagnosis of hepatitis E
    TAKAHASHI MASAHARU, OKAMOTO HIROAKI
    肝胆膵 47(5) 647-656 Nov. 2003
  • 細菌学・ウイルス学 市販ブタ肝臓からのHEV遺伝子検出
    岡本宏明
    医学のあゆみ 207(8) 561 Nov. 2003
  • NATスクリーニングにおいて日本で初めて見いだされたB型肝炎ウイルスgenotype Hのゲノム解析
    大沼均, 板橋正子, 岩田明子, 加藤尚美, 岡本宏明, 草刈隆, 真弓忠, 高田雅彦, 井上肇
    血液事業 26(3) 493-502 Nov. 2003
  • 非典型的経過をたどったE型劇症肝炎の2症例
    岡沢林太郎, 古山準一, 杉沢憲, 草間敬司, 高橋麦, 高木秀雄, 森園竜太郎, 宮崎慎一, 岡本宏明
    肝臓 44(Supplement 3) A540 Oct. 2003
  • 北海道東部地方に於けるE型肝炎ウイルス感染の疫学調査
    田辺利男, 比嘉憲久, 水尾仁志, 杉沢憲, 草間啓司, 古山準一, 高橋麦, 森園竜太郎, 岡本宏明
    肝臓 44(Supplement 3) A538 Oct. 2003
  • 一般住民検診者からみた岩手県におけるE型肝炎ウイルス抗体陽性率の年次的推移
    宮坂昭生, 葛西幸穂, 熊谷一郎, 岡野継彦, 妻神重彦, 遠藤龍人, 阿部弘一, 鈴木一幸, 岡本宏明
    肝臓 44(Supplement 2) A452 Sep. 2003
  • ALT値正常献血者とALT高値(≧80 IU/L)献血者におけるHEV感染状況
    長谷川倫子, 植木美香, 小林由里, 落合直美, 鈴木祐子, 須永純子, 福田さと子, 津田文男, 岡本宏明
    血液事業 26(2) 330 Aug. 2003
  • 最新の臨床検査 我が国におけるE型肝炎の現況と診断
    岡本宏明
    SRL宝函 27(1) 12-19 May 2003
  • 日本の異なる2地域の献血者におけるHEV抗体陽性率の対比
    福田さと子, 藤村邦子, 長谷川倫子, 鈴木祐子, 須永純子, 伊藤八重子, 松尾美千栄, 岡本宏明, 津田文男
    血液事業 26(1) 25-30 May 2003
  • C型肝炎ウイルス(HCV)の超可変領域における変異に関する検討―母児感染をきたした2症例における観察から―
    石井勉, 有賀裕道, 平井滋, 氏家二郎, 鈴木仁, 馬場千華子, 大戸斉, 岡本宏明
    日本輸血学会雑誌 49(2) 310 May 2003
  • 2002年/ニュースの中の感染症―2 我が国におけるE型肝炎の現状と診断
    岡本宏明
    SRL感染症フォ-ラム講演集 7th 20-32 May 2003
  • HIV感染者に認められた稀な遺伝子型(E型,G型,およびH型)のHBV株の全塩基配列の解析
    柴山隆男, 林星舟, 佐伯俊一, 大竹寛雄, 田中武, 比留間潔, 津田文男, 岡本宏明
    肝臓 44(Supplement 1) A178 Apr. 2003
  • 我が国におけるE型急性肝炎の臨床像:A型急性肝炎との比較検討
    妻神重彦, 遠藤龍人, 熊谷一郎, 宮坂昭生, 水尾仁志, 須貝吉樹, 赤羽賢浩, 矢島義昭, 岡本宏明
    肝臓 44(Supplement 1) A81 Apr. 2003
  • 札幌市地域における散発性急性E型肝炎の臨床病理学的およびウイルス学的特徴
    水尾仁志, 杉沢憲, 古山準一, 草間敬司, 高橋麦, 高木秀雄, 宮崎慎一, 森園竜太郎, 岡本宏明
    肝臓 44(Supplement 1) A137 Apr. 2003
  • 岩手県の一般住民におけるE型肝炎ウイルス感染の実態
    葛西幸穂, 阿部弘一, 宮坂昭生, 熊谷一郎, 岡野継彦, 妻神重彦, 遠藤龍人, 鈴木一幸, 岡本宏明
    肝臓 44(Supplement 1) A291 Apr. 2003
  • インターフェロン治療開始前の血清KL‐6値測定は,C型慢性肝炎に対するインターフェロン投与中の間質性肺炎発症の予測に有用である
    時田元, 村田進, 福井秀雄, 田中晃久, 上司裕史, 矢倉道泰, 原田英治, 岡本宏明
    肝臓 44(Supplement 1) A134 Apr. 2003
  • An acute hepatitis case domestically infected with a hepatit E virus whose nucleotide sequence showed a high similarity to that from a domestic swine in Japan
    YAJIMA Yoshiaki, TAKAHASHI Nobutaka, YAMAGISHI Hatsushi, KODAMA Ai, MIYAZAKI Atsushi, SUGIYAMA Koichi, EDA Yoshiki, OKAMOTO Hiroaki
    Nippon Shokakibyo Gakkai Zasshi 100(4) 454-458 Apr. 2003
  • 日本の国内産ブタから得られたE型肝炎ウイルスと高い一致率を示す塩基配列のウイルス株に感染していた急性肝炎国内発症の1例
    矢島義昭, 高橋信孝, 山岸初志, 小玉藍, 宮崎敦史, 杉山幸一, 枝幸基, 岡本宏明
    日本消化器病学会雑誌 100(4) 454-458 Apr. 2003
  • 日本のブタより検出されたE型肝炎ウイルス(HEV)の塩基配列と高い一致率を示すHEVが分離された海外渡航歴のないE型急性肝炎の一例
    山岸初志, 矢島義昭, 高橋信孝, 小玉藍, 宮崎敦史, 杉山幸一, 枝幸基, 岡本宏明
    日本消化器病学会雑誌 100 A195 Mar. 2003
  • E型肝炎の現在 人畜共通感染症としてのE型肝炎
    岡本宏明
    化学療法の領域 19(3) 395-400 Mar. 2003
  • 成因不明の劇症肝炎におけるE型肝炎ウイルスの関与
    阿部弘一, 遠藤龍人, 熊谷一郎, 川上格, 岩井正勝, 滝川康裕, 鈴木一幸, 岡本宏明, 真弓忠
    肝臓 43(12) 598 Dec. 2002
  • 黄だんが遷延した日本固有株によるE型肝炎の一例
    久野亜希子, 井戸健一, いそ田憲夫, 佐藤義明, 小野和則, 大竹俊哉, 菅野健太郎, 岡本宏明, 斉藤健
    肝臓 43(Supplement 3) A490 Nov. 2002
  • 20年前肝炎発症時にE型肝炎ウイルス感染を認めた2症例
    相川達也, 宮本久仁子, 小島真樹, 岡本宏明
    肝臓 43(Supplement 3) A492 Nov. 2002
  • 本邦固有株による急性E型肝炎の1例
    時田元, 村田進, 福井秀雄, 田中晃久, 上司裕史, 矢倉道泰, 原田英治, 岡本宏明
    肝臓 43(Supplement 3) A490 Nov. 2002
  • 海外渡航歴のない散発性E型急性肝炎と思われる1例 HEV遺伝子配列の検討
    小島敏明, 中山晴夫, 須貝吉樹, 岡本宏明
    肝臓 43(Supplement 3) A493 Nov. 2002
  • E型肝炎ウイルス感染による劇症肝炎
    相川達也, 小島真樹, 岡本宏明
    肝臓 43(Supplement 3) A492 Nov. 2002
  • 薬剤性肝障害にE型肝炎を合併し重症化した1例
    及川寛太, 宮坂昭生, 佐藤慎一郎, 遠藤龍人, 岩井正勝, 阿部弘一, 滝川康裕, 鈴木一幸, 岡本宏明
    肝臓 43(Supplement 3) A491 Nov. 2002
  • HIV感染者におけるB型肝炎ウイルスの遺伝子型
    柴山隆男, 林星舟, 佐伯俊一, 大竹寛雄, 田中武, 比留間潔, 津田文男, 岡本宏明
    肝臓 43(Supplement 2) A382 Sep. 2002
  • 散発性急性肝炎(NANBNC型)におけるHEVの関与について
    水尾仁志, 杉沢憲, 高木秀雄, 宮崎慎一, 森園竜太郎, 岡和田敦, 横倉基, 田辺利男, 岡本宏明
    肝臓 43(Supplement 2) A395 Sep. 2002
  • 非A非B非C型急性肝炎におけるE型肝炎の実態
    及川寛太, 遠藤龍人, 熊谷一郎, 佐藤慎一郎, 阿部弘一, 滝川康裕, 鈴木一幸, 岡本宏明, 真弓忠
    肝臓 43(Supplement 2) A395 Sep. 2002
  • 献血者における年代別及び性別のHEV抗体陽性率
    須永純子, 落合直美, 長谷川倫子, 鈴木祐子, 福田さと子, 鈴木功雄, 尾形佳郎, 津田文男, 岡本宏明
    血液事業 25(2) 388 Aug. 2002
  • 歯髄からのTTウイルス検出
    西海栄一, 津田文男, 岡本宏明
    栃木県歯科医学会誌 54th 97-100 Aug. 2002
  • A case of domestically infected acute hepatitis E
    SATOU Shin, IDO Ken-ichi, ISODA Norio, HIRASAWA Tomosuke, IINO Satosi, HOZUMI Masanori, ONO Kazunori, NAGAMINE Nobuhiko, SUGANO Kentaro, OKAMOTO Hiroaki, MAYUMI Makoto
    Kanzo 43(7) 332-335 Jul. 2002
  • TTV DNA titer別にみたC型慢性肝疾患の病態の検討 特に肝細胞癌の合併について
    時田元, 村田進, 福井秀雄, 上司裕史, 矢倉道泰, 原田英治, 岡本宏明
    肝臓 43(Supplement 1) A93 May 2002
  • TTウィルス感染児におけるウィルス排除
    竹内千華子, 大戸斉, 氏家二郎, 佐藤章, 林明男, 石古博昭, 西沢勉, 岡本宏明
    日本輸血学会雑誌 48(2) 180 Apr. 2002
  • A revention Complete Information on Hepatitis C. Organization and function of the hepatitis C virus genome.
    OKAMOTO HIROAKI
    肝胆膵 43(5) 565-574 Nov. 2001
  • TTV感染別にみた,インターフェロン治療によるHCVのsustained virologic responderにおける治療前後の血小板数の検討
    時田元, 福井秀雄, 村居晴洋, 上司裕史, 矢倉道泰, 原田英治, 岡本宏明
    肝臓 42(Supplement 2) A439 Sep. 2001
  • HIV感染者の経過観察におけるTTウイルスDNA量の推移
    柴山隆男, 林星舟, 佐伯俊一, 大竹寛雄, 田中武, 増田剛太, 比留間潔, 岡本宏明, 津田文男
    肝臓 42(Supplement 2) A439 Sep. 2001
  • 非アルコール性脂肪肝におけるTTVの検出 TTV陽性例の臨床像の検討
    杉本元信, 竹内靖雄, 岡本宏明, 真弓忠
    肝臓 42(Supplement 2) A439 Sep. 2001
  • 核酸増幅検査によりウインドウ期に見出されたHBV感染献血者2例の経時的感染推移
    長谷川倫子, 石川真美, 鈴木裕子, 須永純子, 福田さと子, 尾形佳郎, 津田文男, 岡本宏明
    血液事業 24(2) 328 Aug. 2001
  • 全唾液中のTTウイスル検出
    西海栄一, 津田文男, 岡本宏明
    栃木県歯科医学会誌 53rd 63-67 Aug. 2001
  • Basic research on TT virus (TTV)
    OKAMOTO Hiroaki
    29(3) 101-113 Jul. 2001
  • TTVの基礎的研究
    岡本宏明
    臨床とウイルス 29(3) 101-113 Jul. 2001
  • HBV感染におけるいわゆるウインドウ期のHBV DNA検出頻度
    石川真美, 長谷川倫子, 鈴木祐子, 須永純子, 福田さと子, 永井政勝, 津田文男, 岡本宏明
    血液事業 24(1) 39-42 May 2001
  • TTV(genotype 1a)のチンパンジー感染実験とその臨床的意義
    俵章夫, 井上泰輔, 坂本穣, 岡田俊一, 赤羽賢浩, 石川孝志, 岡本宏明
    肝臓 42(Supplement 1) A102 Apr. 2001
  • TTV感染がC型慢性肝炎の血小板数減少に影響を及ぼす機序の検討
    時田元, 福井秀雄, 村居晴洋, 上司裕史, 矢倉道泰, 原田英治, 岡本宏明
    肝臓 42(Supplement 1) A260 Apr. 2001
  • Molecular virological analysis of TT virus (Ministry of Health, Labor and Welfare S).
    OKAMOTO HIROAKI
    非A非B型肝炎の予防、疫学に関する研究 平成12年度報告書 総括研究報告書 分担研究報告書 65-73 2001
  • 消化器感染症と分子医学 (2) 基礎と臨床 肝・胆・すいを中心に 基礎 TTVの分子医学
    岡本宏明
    現代医療 32 2759-2765 Dec. 2000
  • Molecular Virology of TT virus (TTV)
    OKAMOTO Hiroaki, MAYUMI Makoto
    Virus 50(2) 259-271 Dec. 2000
  • TTVおよび関連ウイルス 1. TTVの分子ウイルス学
    岡本宏明, 真弓忠
    ウイルス 50(2) 259-271 Dec. 2000
  • HCV抗体陽性供血者におけるHCV RNA検出補助手段としての補体のcold activation
    石川真美, 長谷川倫子, 鈴木祐子, 須永純子, 荻原静江, 福田さと子, 永井政勝, 津田文男, 岡本宏明
    血液事業 23(3) 537-541 Nov. 2000
  • 海外渡航歴のないE型急性肝炎の1例
    佐藤慎, いそ田憲夫, 平沢知介, 佐藤彰洋, 飯野聡, 井戸健一, 菅野健太郎, 岡本宏明, 真弓忠
    肝臓 41(Supplement 3) A521 Oct. 2000
  • 脂肪肝におけるTTVの検出と病因的意義
    杉本元信, 竹内靖雄, 岡本宏明, 真弓忠
    肝臓 41(Supplement 3) A495 Oct. 2000
  • TTV感染別にみた慢性肝疾患患者における末梢血液検査値の検討
    時田元, 福井秀雄, 村居晴洋, 上司裕史, 矢倉道泰, 原田英治, 岡本宏明
    肝臓 41(Supplement 2) A403 Sep. 2000
  • 臨床遺伝子学2000 消化器 TTVについて
    岡本宏明
    最新医学 55 2211-2220 Sep. 2000
  • HCV抗体検査において判定不能例とされた供血者血液の検討
    鈴木祐子, 石川真美, 長谷川倫子, 石田雄一, 須永純子, 福田さと子, 永井政勝, 津田文男, 岡本宏明
    血液事業 23(2) 480 Aug. 2000
  • TTウイルス
    岡本宏明
    感染・炎症・免疫 30(2) 164-167 Jun. 2000
  • TTウイルスの発見とその後の展開
    岡本宏明
    臨床化学 29 7A-8A Jun. 2000
  • 乳児後期に認められるTTV高ウイルス血症と病原性に関する検討
    石川孝志, 桃谷孝之, 佐々木暢彦, 岡本宏明, 津田文男
    肝臓 41(Supplement 1) A56 May 2000
  • TTV感染別にみた脂肪肝の病態の検討 non‐alcoholic steatohepatitisを含む
    時田元, 松林守, 福井秀雄, 村居晴洋, 上司裕史, 矢倉道泰, 原田英治, 岡本宏明
    肝臓 41(Supplement 1) A59 May 2000
  • 非A~G型肝炎ウイルス研究の進展 TTウイルスについて
    真弓忠, 板橋正子, 大島節子, 岡本宏明, 小田美沙子, 岸本純一, 俵章夫, 津田文男, PENG Y
    月刊医学と薬学 43(4) 732-738 Apr. 2000
  • TTウイルス(TTV)の分子生物学
    岡本宏明
    Mebio 17(4) 108-116 Apr. 2000
  • 肝炎ウイルス学
    岡本宏明, 真弓忠
    透析患者の合併症とその対策(9) 1-13 Mar. 2000
  • TTウイルスについての分子ウイルス学的研究 (厚生省S)
    岡本宏明
    非A非B型肝炎の予防,疫学に関する研究 平成11年度報告書 総括研究報告書 分担研究報告書 74-78 2000
  • TTウイルスについての分子ウイルス学的研究 (厚生省S)
    岡本宏明
    非A非B型肝炎の予防,疫学に関する研究非A非B型肝炎の臨床的総合研究 平成11年度研究報告書 74-78 2000
  • TTVに対するIFNの抗ウイルス効果 (厚生省S)
    赤羽賢浩, 俵章夫, 内藤成子, 井上泰輔, 坂本穣, 岡田俊一, 宮崎吉規, 岡本宏明
    非A非B型肝炎の予防,疫学に関する研究非A非B型肝炎の臨床的総合研究 平成11年度研究報告書 175 2000
  • Present state of molecule virological research of the TT virus.
    OKAMOTO HIROAKI
    日本輸血学会雑誌 45(6) 788-790 Dec. 1999
  • ウイルス肝炎 肝炎ウイルス
    岡本宏明
    からだの科学(208) 20-25 Sep. 1999
  • Acute hepatitis associated with TT virus infection. Virological feature and diagnosis.
    OKAMOTO HIROAKI
    肝胆膵 39(2) 195-202 Aug. 1999
  • Advance in Molecular Aspects of Viral Hepatitis. Molecular Virology of TT Virus.
    OKAMOTO HIROAKI
    最新医学 54(8) 1890-1899 Aug. 1999
  • The latest trends of viral hepatitis medical care. Development of hepatitis viral research.
    OKAMOTO HIROAKI, MAYUMI TADASHI
    内科 84(2) 204-212 Aug. 1999
  • Blood intermediation infectious diseases and blood transfusion. Blood intermediation infectious diseases. TT virus.
    OKAMOTO HIROAKI, MAYUMI TADASHI
    月刊臨床と研究 76(7) 1267-1273 Jul. 1999
  • Digestive system disease. State of arts (Ver.2). II. Liver and bile and pancreas. Advance on the basic and clinical research of the pathophysiology. TT virus (TTV).
    OKAMOTO HIROAKI, MAYUMI MAKOTO
    医学のあゆみ 93-99 Jun. 1999
  • Molecular virology of TT virus.
    OKAMOTO HIROAKI
    日本臨床 57(6) 1239-1249 Jun. 1999
  • Risk Factors of Vertical Transmission of GB Virus C/Hepatitis G Virus
    9(1) "S-107"-"S-108" May 1999
  • Risk Factors of Vertical Transmission of GB Virus C/Hepatitis G Virus.
    OTO HISASHI, UJIIE JIRO, SATO AKIRA, OKAMOTO HIROAKI, MAYUMI TADASHI
    日本産婦人科・新生児血液学会誌 9(1) S.107-S.108 May 1999
  • A Novel Human DNA Virus-TT Virus(TTV).
    OKAMOTO HIROAKI
    最新医学 54(3) 490-496 Mar. 1999
  • Hepatitis. The TT virus.
    OKAMOTO HIROAKI
    臨床検査 43(3) 319-323 Mar. 1999
  • Controversy of internal medical care. Digestive tract. Is HGV hepatitis virus or not ?
    OKAMOTO HIROAKI
    内科 83(2) 260-263 Feb. 1999
  • TTウイルスの分子ウイルス学的解析 (厚生省S)
    岡本宏明
    非A非B型肝炎の予防,疫学に関する研究 平成10年度研究報告書 総括研究報告書 分担研究報告書 21-25 1999
  • 非A非B型肝炎の臨床的総合研究 TTVの便中排せつ (厚生省S)
    赤羽賢浩, 内藤成子, 井上泰輔, 坂本穣, 相野田隆雄, 宮崎吉規, 岡本宏明
    非A非B型肝炎の予防,疫学に関する研究非A非B型肝炎の臨床的総合研究 平成10年度研究報告書 112-113 1999
  • 非A非B型肝炎の予防,疫学に関する研究 TTウイルスの分子ウイルス学的解析 (厚生省S)
    岡本宏明
    非A非B型肝炎の予防,疫学に関する研究非A非B型肝炎の臨床的総合研究 平成10年度研究報告書 20-24 1999
  • Recent topics on liver diseases. Progress in diagnosis. Mutation and serum marker of hepatitis B virus.
    OKAMOTO HIROAKI
    カレントテラピー 16(11) 2038-2045 Nov. 1998
  • An autopsy case of fulminant hepatitis with TTV and HBV infection in the elderly.
    TOKITA HAJIME, MURAI SEIYO, KOJIMA HIROSHI, KAMITSUKASA HIROSHI, YAGURA MICHIYASU, HARADA HIDEHARU, HEBISAWA AKIRA, OKAMOTO HIROAKI
    月刊医学と薬学 40(4) 657-661 Oct. 1998
  • Hepatitis G. 1. Structure of virus.
    OKAMOTO HIROAKI
    犬山シンポジウム 20th 2-10 Aug. 1998
  • Differences of occurence areas in TTV-DNA positive and negative fulminant hepatitis cases.
    Kanzo 39(6) 410-411 Jun. 1998
  • Twenty-four week administration of recombinant interferon alfa 2a for chronic hepatitis B
    KANAI Koichi, KAKO Makoto, AIKAWA Tatsuya, HINO Kunihiko, TSUBOUCHI Hirohito, TAKEHIRA Yasunori, IWABUCHI Shogo, KAWASAKI Tsunehisa, TSUDA Fumio, OKAMOTO Hiroaki, MAYUMI Makoto
    Kanzo 39(2) 62-67 Feb. 1998
  • Study on new virus - TTV separated from posttransfusion hepatitis patient of the unknown origin. ( Ministry of Health and Welfare S ).
    OKAMOTO HIROAKI
    厚生省非A非B型肝炎研究班 平成9年度研究報告書 12-14 1998
  • Detection of TTV in non-A - G type liver disease. IFN treatment for chronic hepatitis C of the TTVpositive. ( Ministry of Health and Welfare S ).
    AKAHANE MASAHIRO, NAITO SEIKO, INOUE TAISUKE, SAKAMOTO MINORU, OKADA SHUN'ICHI, TAKEDA KIYOSHI, MIYAZAKI YOSHINORI, OKAMOTO HIROAKI, SUZUKI HIROSHI
    厚生省非A非B型肝炎研究班 平成9年度研究報告書 96-97 1998
  • HLA types associated with the clearance of hepatitis C virus in blood donors.
    OCHIAI NAOMI, MATSUKAWA YURI, KANEKO TOSHIFUMI, FUKUDA SATOKO, NAGAI MASAKATSU, ONISHI HIROSHI, TSUDA FUMIO, OKAMOTO HIROAKI
    血液事業 20(3) 177-181 Nov. 1997
  • GB virus C infection by blood transfusions.
    ICHIMIYA MUNEHIRO, SHINOHARA MASAKATSU, SOGAWA IKUYO, NAGAO KAYOKO, IDE KUMIKO, YOSHIDA MIHOKO, TSUDA FUMIO, OKAMOTO HIROAKI
    医学検査 46(11) 1582-1587 Nov. 1997
  • Fulminant hepatitis with infection of GB type hepatitis virus.
    Kanzo 38(9) 574-575 Sep. 1997
  • Infection with hepatitis G virus(GBV-C/HGV)in patients with chronic liver disease
    KOJIMA Maki, KANAZAWA Kazuya, HAKAMADA Taku, ALKAWA Atsuya, SAWADA Naoto, TSUDA Fumio, OKAMOTO Hiroaki
    Kanzo 38(9) 535-540 Sep. 1997
  • Mutation of virus of hepatitis B and pathology of hepatitis B.
    Kanzo 38(8) 477-488 Aug. 1997
  • Collaborative study of mother-to-infant transmission of hepatitis C virus in general pregnant women.
    IMAMURA SHIN'YA, OTO HITOSHI, HANDO KEIICHI, HATTORI MASAO, OKAMOTO HIROAKI, TAKASAKI KATSUNORI, MUNAKATA MASAHIRO, OSUGI KAZUO, HIRAI SHIGERU
    産婦人科治療 75(2) 212-216 Aug. 1997
  • Present state of the hepatitis. Gene classification and molecular epidemiology of the C and G type hepatitis virus.
    OKAMOTO HIROAKI
    臨床科学 33(8) 965-974 Aug. 1997
  • 200 words to be known - contemporary medical terms. HBV mutant.
    OKAMOTO HIROAKI
    医学のあゆみ 181(9) 632 May 1997
  • Detection of hepatitis C virus genotypes by the polymerase chain reaction.
    OKAMOTO HIROAKI
    実験医学 15(7) 789-792 May 1997
  • Hepatitis G virus (HGBV-C/HGV) as a putative agent for non-A to E hepatitis.
    OKAMOTO HIROAKI
    日本臨床 55(3) 515-522 Mar. 1997
  • Genetic analysis of HBV variant of child carrier after taking HBV infection block between mother and child.
    Kanzo 38(2) 107-108 Feb. 1997
  • Diversity of a genome of hepatitis C virus and polymorphism of the hepatitis.
    OKAMOTO HIROAKI
    医学のあゆみ 180(4) 230-231 Jan. 1997
  • Study on gene structure and physiochemical property of G-type hepatitis virus. ( Ministry of Health and Welfare S ).
    OKAMOTO HIROAKI
    厚生省非A非B型肝炎研究班 平成8年度研究報告書 8-9 1997
  • Abnormal porphyrin metabolism in hepatitis C and tardive skin porphyria combined with hepatitis C.
    KONDO MASAO, HORIE YUTAKA, KAWASAKI HIRONAKA, SAEKI SHUN'ICHI, MISHIRO SHUNJI, OKAMOTO HIROAKI, MAYUMI TADASHI
    日本臨床代謝学会記録 34 63 1997
  • Interferon treatment for chronic hepatitis C which recognized the GBV-C superinfection. ( Ministry of Health and Welfare S ).
    AKABANE MASAHIRO, INOUE TAISUKE, SAKAMOTO YUZURU, OKADA SHUN'ICHI, MIYAZAKI YOSHINORI, NAITO SEIKO, OKAMOTO HIROAKI, SUZUKI HIROSHI
    厚生省非A非B型肝炎研究班 平成8年度研究報告書 84-85 1997
  • Biochemistry of Hepatitis C Virus Infection in Patients with Acquired Porphyria Cutanea Tarda.
    KONDO MASAO, HORIE YUTAKA, SAEKI SHUN'ICHI, OKAMOTO HIROAKI, MISHIRO SHUNJI
    ポルフィリン 5(2/3) 273-280 Nov. 1996
  • Genetic analysis of hepatitis viruses and its recent advance.
    OKAMOTO HIROAKI
    綜合臨床 45(11) 2474-2481 Nov. 1996
  • HCV and HBV markers in Japanese Patients with Porphyria Cutanea Tarda.
    HORIE YUTAKA, KONDO MASAO, MISHIRO SHUNJI, OKANO JUN'ICHI, KITAMURA ATSUSHI, YAMAMOTO SHIN'ICHIRO, ITO TOSHIO, OKAMOTO HIROAKI, MAYUMI TADASHI
    ポルフィリン 5(2/3) 267-271 Nov. 1996
  • Genomic organizaiton and its function.
    OKAMOTO HIROAKI
    消化器病セミナー 64 1-15 Sep. 1996
  • New development of virus vaccine. Hepatitis virus - bases.
    OKAMOTO HIROAKI
    Bio Clin 11(9) 651-655 Aug. 1996
  • Hepatitis virus genome and its mutation. HBV pre - S region and S-gene.
    AKABANE TAKAHIRO, INOUE YASUSUKE, KONO HIROKI, NAITO SHIGEKO, SAKAMOTO MINORU, OKADA SHUN'ICHI, TAKEDA KIYOSHI, SUZUKI HIROSHI, OKAMOTO HIROAKI
    犬山シンポジウム 19th 92-99 Jul. 1996
  • Measurement of GBV-C RNA in serum of patient undergoing kidney dialysis.
    Kanzo 37(6) 348-349 Jun. 1996
  • Molecular evolution of hepatitis C virus and its closely related virus
    OKAMOTO Hiroaki
    Virus 46(1) 13-21 Jun. 1996
  • Molecular evolution of hepatitis C virus and its closely related virus.
    OKAMOTO HIROAKI
    ウイルス 46(1) 13-21 Jun. 1996
  • Mutation of hepatitis B virus genome and its clinical significance.
    OKAMOTO HIROAKI
    肝胆膵 32(6) 871-878 Jun. 1996
  • Measurement of GBV-C RNA in serum of patient undergoing kidney dialysis.
    SHIMIZU MASARU, KOJIMA MINEO, OHASHI HIROSHIGE, TAKAHASHI ZEN'YATA, KAMETANI MASAAKI, ISHIGURO MOTOYUKI, TSUDA FUMIO, OKAMOTO HIROAKI
    肝臓 37(6) 348-349 Jun. 1996
  • Genotyping and molecular epidemiology of hepatitis C virus.
    TOKITA HAJIME, OKAMOTO HIROAKI
    肝胆膵 32(6) 821-828 Jun. 1996
  • Non-A non- C type and frequency of GBV-C hepatitis in hepatitis C. ( Ministry of Health and Welfare S ).
    AKABANE TAKAHIRO, MIYAZAKI YOSHINORI, NAITO SHIGEKO, SAKAMOTO MINORU, OKAMOTO HIROAKI, SUZUKI HIROSHI
    厚生省非A非B型肝炎研究班 平成7年度研究報告書 95 1996
  • Genotype of HCV (Genotype classification by the analysis of the entire base sequence ). ( Ministry of Health and Welfare S ).
    OKAMOTO HIROAKI
    厚生省非A非B型肝炎研究班 平成7年度研究報告書 8 1996
  • Gene structure of hepatitis G virus and physicochemical properties. ( The Ministry of Health and Welfare S ).
    OKAMOTO HIROAKI
    厚生省非A非B肝炎基礎研究班 平成8年度 研究報告書 18-19 1996
  • Hepatitis C. A result for the eradication which is asked at present. New hepatitis virus. GB virus and HGV.
    OKAMOTO HIROAKI, MAYUMI TADASHI
    Med Pract 12(11) 1617-1620 Nov. 1995
  • Anti-HBs escape mutants. Implication of neutralization escape and diagnostic escape.
    OKAMOTO HIROAKI
    日本臨床 53(1995 Zokan Gekan. Bunshi...) 212-222 Oct. 1995
  • Classification of hepatitis C virus genotypes and its application to molecular epidemiology.
    OKAMOTO HIROAKI
    日本臨床 53(1995 Zokan Jokan. Bunshi...) 71-79 Sep. 1995
  • PCR-based genotyping with genotype-specific primers derived from the C gene of HCV genome.
    OKAMOTO HIROAKI
    日本臨床 53(1995 Zokan Jokan. Bunshi...) 312-320 Sep. 1995
  • Special issue : Hepatic cell injury in chronic hepatitis and their control.To diseases of possible treatment from diseases of follow-up.Structure of hepatitis B virus (HBV) and the mechanism of growth.
    OKAMOTO HIROAKI, MISHIRO SHUNJI, MAYUMI TADASHI
    Mebio 12(4) 18-23 Apr. 1995
  • Natural process of hepatitis C and modifying factors.Progress and infectious factors of HCV infection.
    OKAMOTO HIROAKI
    肝臓 36(3) 176-179 Mar. 1995
  • Genotypes of hepatitis C virus. Classification and its clinical significance.
    OKAMOTO HIROAKI
    医学のあゆみ 171(14) 994-998 Dec. 1994
  • Diagnosis and treatment of viral hepatitis.Genotype and therapeutic response of hepatitis C virus.
    OKAMOTO HIROAKI
    Med Pract 11(7) 1259-1264 Jul. 1994
  • PCR-based HCV genotyping with type-specific primers derived from core gene and IFN responsiveness.
    OKAMOTO HIROAKI
    日本臨床 52(7) 1699-1706 Jul. 1994
  • Special issue : Hepatitis C - recent progresses.Significance of hepatitis C virus markers.
    OKAMOTO HIROAKI
    臨床成人病 24(6) 710-717 Jun. 1994
  • Hepatitis B virus.
    OKAMOTO HIROAKI
    Pharma Med 12(2) 15-23 Feb. 1994
  • Hepatitis C virus(HCV) genome and liver disease with HCV infection.
    OKAMOTO HIROAKI
    肝胆膵 28(1) 53-59 Jan. 1994
  • Blood transfusion infectious disease.1.Blood transfusion post-hepatic fever.HCV gene analysis and its significance.
    OKAMOTO HIROAKI
    日本輸血学会雑誌 39(6) 1002-1006 Dec. 1993
  • Structure of the hepatitis B virus genome and its function.
    OKAMOTO HIROAKI
    Pharma Med 11(12) 155-163 Dec. 1993
  • Special issue: Hepatitis C virus. Genetic mutation of hepatitis C virus and host's immune response.
    OKAMOTO HIROAKI
    ウイルス 43(2) 305-313 Dec. 1993
  • HBs escape mutants.
    OKAMOTO HIROAKI
    肝胆膵 27(4) 555-562 Oct. 1993
  • Special issue : - present condition and prospect aiming at the elimination of hepatitis virus.Genotype of hepatitis C virus.From a worldwide viewpoint.
    OKAMOTO HIROAKI
    カレントテラピー 11(9) 1778-1782 Sep. 1993
  • Screening of HCV carrier in donor.
    FUKUDA SATOKO, ISHIKAWA MAMI, TAKAHASHI MASAHIRO, KANEKO TOSHIFUMI, HAGIWARA SHIZUE, ITO MASAHIRO, SUZUKI TAKASHI, TSUDA FUMIO, OKAMOTO HIROAKI
    血液事業 16(3) 353-354 Sep. 1993
  • Viral hepatitis - basics and clinics.Hepatitis C.
    OKAMOTO HIROAKI
    臨床とウイルス 21(4) 211-217 Sep. 1993
  • Supersensitive HCV by polymerase chain reaction Establishment of detection method of RNA.
    IIZUKA HISAO, AIHARA SHINOBU, MATSUMOTO CHIEKO, FUJIMURA KAYOKO, OKAMOTO HIROAKI
    血液事業 16(3) 257-259 Sep. 1993
  • Medical biotechnology.From tip research to the bedside.Hepatitis C virus genome.
    OKAMOTO HIROAKI
    診断と治療 81(7) 1415-1422 Jul. 1993
  • HBs抗体およびHBc抗体陽性供血者に於けるHBV DNAの検出
    荻原静江, 高橋正広, 金子俊文, 長谷川倫子, 鈴木祐子, 須永純子, 福田さと子, 鈴木孝, 岡本宏明
    血液事業 16(2) 158 Jun. 1993
  • Liver injury treatment.Genotypes of hepatitis C virus and applications to treatment.
    OKAMOTO HIROAKI
    Med Pract 10(5) 925-930 May 1993
  • Treatment of C type chronic hepatitis.Centering on interferon therapy.Basis for HCV.Structure and diversity of the HCV gene.
    OKAMOTO HIROAKI
    治療 75(4) 1087-1094 Apr. 1993
  • 病態生理の基礎的・臨床的研究の進歩 B型肝炎ウイルスとその遺伝子構造
    岡本宏明
    医学のあゆみ(Mar) 62-65 Mar. 1993
  • Special issue : Knowledge of C type hepatitis necessary for primary care and medical care practice.Virus markers for diagnosis of C type hepatitis.
    OKAMOTO HIROAKI
    日本医師会雑誌 109(5) 678-686 Mar. 1993
  • 特集/注目のウイルスマーカー ウイルス感染症診断へのアプローチ I. 肝炎ウイルスとそのマーカー B型肝炎ウイルス(HBV)
    岡本宏明
    Med Technol 21(3) 197-203 Mar. 1993
  • Determination of hepatitis C virus genotype and its clinical significance.
    OKAMOTO HIROAKI
    肝胆膵 25(5) 955-964 Nov. 1992
  • Usefulness of hepatitis C virus core antibodies in blood donors. Estimation with Genome RNA Detection.
    FUKUDA SATOKO, KOBAYASHI NORIO, SUZUKI TAKASHI, TSUDA FUMIO, OKAMOTO HIROAKI
    日本輸血学会雑誌 38(5) 613-618 Nov. 1992
  • HCV‐RNA陽性の自己免疫性肝炎(様)症例におけるHCVサブタイプの検索
    井本勉, 岡本宏明, 井上恭一, 福田善弘, 樋口清博, 竹内孝男, 池原幸辰, 小林昌樹, 山本伸
    肝臓 33(9) 732 Sep. 1992
  • Detection of HBV DNA and sequence analyses of genomic mutations.
    岡本宏明
    医学のあゆみ 162(9) 544-549 Aug. 1992
  • Capability of the Anti-pre-S2 Antibody Raised by Vaccination with a Pre-S2 Containing HB Vaccine (TGP-943) to Neutralize Hepatitis B Virus in vitro.
    MACHIDA ATSUHIKO, TSUDA FUMIO, OKAMOTO HIROAKI, DOMOTO KENJI, FUKAZAWA ICHIRO, MISHIRO SHUNJI
    基礎と臨床 26(8) 3525-3530 Jul. 1992
  • Special issue : virus receptor and PCR diagnosis.An advance of each viral disease diagnosis by the PCR method.Hepatitis C virus.
    OKAMOTO HIROAKI
    Mebio 9(6) 62-69 Jun. 1992
  • Characterization of genomic structure of hepatitis C virus.
    OKAMOTO HIROAKI
    医学のあゆみ 161(5) 298-302 May 1992
  • Seminar on hepatitis C : How is the diagnosis made ?The characteristic of HCV gene structure and its application to the clinical diagnosis.
    OKAMOTO HIROAKI
    Med Pract 9(5) 741-747 May 1992
  • Analysis of the p53 hotspot mutation in Japanese patients with HBsAg positive hepatocellular carcinoma.
    KANAI NOBUYUKI, SUGAI YOSHIKI, AKAHANE YOSHIHIRO, OKAMOTO HIROAKI
    肝臓 33(5) 436-437 May 1992
  • Type classification of virus of hepatitis C.
    OKAMOTO HIROAKI
    実験治療(626) 32-33 Mar. 1992
  • Hepatitis Virus and Hepatocarcinogenesis. Typing of Hepatitis C Virus Genomes and its Clinical Application.
    OKAMOTO HIROAKI
    CRC (Cancer Res Clin) 1(1) 20-31 Mar. 1992
  • Disease state and treatment of chronic liver disease.Topics. A genotype of C type hepatitis virus.
    OKAMOTO HIROAKI
    診断と治療 80(2) 295-302 Feb. 1992
  • Hepatitis C virus genome and its typing by PCR with type-specific primers.
    OKAMOTO HIROAKI
    肝胆膵 24(1) 7-14 Jan. 1992
  • Analysis of the p53 hotspot mutation in Japanese patients with HBsAg positive hepatocellular carcinoma.
    KANAI Nobuyuki, SUGAI Yoshiki, AKAHANE Yoshihiro, OKAMOTO Hiroaki
    Kanzo 33(5) 436-437 1992
  • C型肝炎ウイルス構造蛋白の大腸菌による発現とその応用
    加藤尚美, 吉川昭, 立花克己, 佐藤功栄, 児崎宣夫, 岡本宏明
    血液事業 14(4) 759-760 Dec. 1991
  • 献血者におけるC型肝炎ウイルス関連マーカーの検討
    大村和代, 相原忍, 木村千尋, 石田克巳, 石島あや子, 田中建志, 飯塚久雄, 児崎宣夫, 岡本宏明
    血液事業 14(4) 744-745 Dec. 1991
  • Seroepidemiological survey of hepatitis C virus relative anti C100-3, anti CP-9, anti CP-10 and anti GOR antibodies in an endemic area for non-A, non-B hepatitis.
    TOKITA HAJIME, SHIMIZU MASARU, KOJIMA MINEO, TAKAHASHI YOSHIYATA, UDO KAZUMICHI, TANAKA TAKESHI, TSUDA FUMIO, OKAMOTO HIROAKI
    肝臓 32(12) 1093-1100 Dec. 1991
  • C型肝炎ウイルスゲノムの解析
    飯塚久雄, 五反田裕子, 星友二, 児崎宣夫, 岡本宏明
    血液事業 14(4) 756-758 Dec. 1991
  • 供血者におけるHCVキャリアのスクリーニングについて
    福田さと子, 真柄郁子, 長谷川倫子, 鈴木祐子, 須永純子, 荻原静江, 鈴木孝, 津田文男, 岡本宏明
    血液事業 14(4) 763-764 Dec. 1991
  • C型肝炎ウイルスの密度測定
    宮本英朗, 佐藤功栄, 相原忍, 石島あや子, 飯坂斉, 児崎宣夫, 岡本宏明
    血液事業 14(4) 761-762 Dec. 1991
  • C型肝炎ウイルスの遺伝子解析と核酸配列から見たサブタイプ分類
    岡本宏明
    肝臓 32(11) 1074-1076 Nov. 1991
  • Molecular biology and DNA diagnosis of disease.4. DNA diagnosis of infectious disease.Nucleic acid diagnosis of hepatitis B and hepatitis C according to the PCR method.Detection and gene mutation of the virus genome.
    OKAMOTO HIROAKI
    実験医学 9(10) 1263-1268 Jul. 1991
  • Topics of hepatitis C. Subtype of hepatitis C virus and its genetic analysis.
    OKAMOTO HIROAKI
    内科 67(5) 807-812 May 1991
  • Study of an autoimmune hepatitis care of detecting HCV-RNA by PCR method.
    IMOTO TSUTOMU, OKAMOTO HIROAKI, MAYUMI TADASHI, INOUE KYOICHI, ONISHI SABURO, FUKUDA YOSHIHIRO, HIGUCHI KIYOHIRO, TAKEUCHI TAKAO
    肝臓 32(5) 539 May 1991
  • HCV antibody positive rate according to age and sex of donors in Tochigi Prefecture.Titer distribution of HCV antibody and comparison with GPT value and anti-hepatitis B antigen positive rate.
    FUKUDA SATOKO, KANEKO TOSHIFUMI, HASEGAWA NORIKO, SUZUKI YUKO, SUNAGA JUNKO, OGIWARA SHIZUE, KOBAYASHI NORIO, SHIOZAWA MITSURU, OKAMOTO HIROAKI
    血液事業 14(1) 105-107 Mar. 1991
  • Antiviral effect of interferon in patients with chronic hepatitis C who were treated with short term(4-6 weeks) interferon.
    AKABANE TAKAHIRO, OKADA SHUN'ICHI, MIYAZAKI YOSHIKI, SODEYAMA TAKESHI, NAKANO YOSHIYUKI, KIYOSAWA KENDO, FURUTA SEIICHI, TSUDA FUMIO, OKAMOTO HIROAKI
    肝臓 32(3) 243-249 Mar. 1991
  • Hepatitis C virus and its related markers.
    OKAMOTO HIROAKI
    消化器病セミナー 42 1-12 Mar. 1991
  • Genetic analysis of C type hepatitis virus (HCV)5' - ends regions : comparison of base sequence in two different HCV stocks and its clinical application.
    OKAMOTO HIROAKI
    肝臓 32(2) 213-216 Feb. 1991
  • C type hepatitis virus.Analysis application of HCV gene structure region.( Including 5' - untranslation regions ).
    OKAMOTO HIROAKI
    Biomedica 6(2) 127-132 Feb. 1991
  • Point mutation in the precore region of HBV-DNA clones propagated from the sera of patients with fulminant type B hepatitis.
    SHIMIZU MASARU, TOKITA HAJIME, HOSHIYAMA NAOKI, TAKAHASHI ZEN'YATA, KOJIMA MINEO, OKADA SHUN'ICHI, TSUDA FUMIO, YOTSUMOTO SHIGERU, OKAMOTO HIROAKI
    肝臓 32(2) 141-146 Feb. 1991
  • B型肝炎ウイルスとサブタイプとその遺伝子構造
    四元茂, 岡本宏明
    検査と技術 19(1) 71-72 Jan. 1991
  • Point mutation in the precore region of HBV-DNA clones propagated from the sera of patients with fulminant type B hepatitis.
    SHIMIZU Masaru, TOKITA Hajime, HOSHIYAMA Naoki, TAKAHASHI Yoshiyata, KOJIMA Mineo, OKADA Syunichi, TSUDA Fumio, SUGIYAMA Yasushi, YOTSUMOTO Shigeru, OKAMOTO Hiroaki
    Kanzo 32(2) 141-146 1991
  • Seroepidemiological survey of hepatitis C virus relative anti C100-3, anti CP-9, anti CP-10 and anti GOR antibodies in an endemic area for non-A, non-B hepatitis.
    TOKITA Hajime, SHIMIZU Masaru, KOJIMA Mineo, TAKAHASHI Yoshiyata, UDO Kazumichi, TANAKA Takeshi, TSUDA Fumio, OKAMOTO Hiroaki
    Kanzo 32(12) 1093-1100 1991
  • Antiviral effect of interferon in patients with chronic hepatitis C who were treated with short term(4-6 weeks) interferon.
    AKAHANE Yoshihiro, OKADA Shunichi, MIYAZAKI Yoshiki, AINOTA Takao, NAITO Shigeko, SUZUKI Hiroshi, SODEYAMA Takeshi, NAKANO Yoshiyuki, KIYOSAWA Kendo, FURUTA Seiichi, TSUDA Fumio, OKAMOTO Hiroaki
    Kanzo 32(3) 243-249 1991
  • Chronic hepatitis : recent advance.HBV variant incapable to secrete hepatitis Be antigen production.
    YOTSUMOTO SHIGERU, YAMAMOTO KAYOKO, OKAMOTO HIROAKI
    小児内科 22(10) 1543-1546 Oct. 1990
  • Current information on hepatitis B. Hepatitis B during the HBe antibody positive period and a genetic engineering analysis of HB virus in the blood.
    AKABANE TAKAHIRO, OKAMOTO HIROAKI
    臨床医 16(5) 586-589 May 1990
  • Structure of hepatitis B virus and its related serological markers.
    OKAMOTO HIROAKI
    臨床病理 38(5) 568-572 May 1990
  • Transition of the past 11 years of hepatitis Be antigen positive rate in HBs antigen positive blood donors in tochigi prefecture.Age difference and sex difference.
    KANEKO TOSHIFUMI, HASEGAWA SATOKO, SUZUKI YUKO, SUNAGA JUNKO, HAGIWARA SHIZUE, FUKUDA SATOKO, NUMAO KIMIMICHI, SHIOZAWA MITSURU, OKAMOTO HIROAKI
    血液事業 13(1) 184-186 Mar. 1990
  • Hepatitis B virus markers.
    YAMANAKA TARO, YOTSUMOTO SHIGERU, OMI SHIGERU, OKAMOTO HIROAKI
    日本臨床 48(’90 Zokan Ge Kohan’i Ketsueki) 291-297 Feb. 1990
  • Hepatitis delta virus markers.
    YOTSUMOTO SHIGERU, OMI SHIGERU, OKADA SHUN'ICHI, OKAMOTO HIROAKI
    日本臨床 48(’90 Zokan Ge Kohan’i Ketsueki) 304-308 Feb. 1990
  • Hepatitis D virus.
    OKAMOTO HIROAKI
    Immunohaematology 11(1) 23-32 Mar. 1989
  • Epidemiological survey of senior high school students in Tochigi Prefecture on HBV infections disease.Transition of the rate of HBs antigen positivity and HBs antibody positivity during 7 years by each region.
    HASEGAWA NORIKO, SUZUKI YUKO, SUNAGA JUNKO, OGIWARA SHIZUE, FUKUDA SATOKO, NUMAO KIMIMICHI, SHIOZAWA MITSURU, OMI SHIGERU, OKAMOTO HIROAKI
    血液事業 12(1) 12:123-12:125 Mar. 1989
  • Hepatitis B virus and hepatitis delta virus.
    OKAMOTO HIROAKI, MAYUMI MAKOTO
    診断と治療 76(12) 2839-2849 Dec. 1988
  • Persistent infection of viruses and immunity. Hepatitis B virus.
    OKAMOTO HIROAKI, MAYUMI MAKOTO
    免疫薬理 6(3) 141-149 Jul. 1988
  • Structure and functions of hepatitis B virus genes.
    OKAMOTO HIROAKI, MAYUMI MAKOTO
    Med Pract 5(4) 549-554 Apr. 1988
  • Hepatitis B virus related marker.
    OKAMOTO HIROAKI, MAYUMI MAKOTO
    日本臨床 46(’88) 505-524 Feb. 1988
  • Phylogeny and origin of hepatitis B virus.
    OKAMOTO HIROAKI, MAYUMI MAKOTO
    病態生理 7(2) 96-108 Feb. 1988
  • Comparative study on HBV-DNA value and HBV related DNA polymerase using hybridization kit.
    SEKIGUCHI KIYOSHI, OKAMOTO HIROAKI, AKAHANE KENKO
    肝臓 28(2) 268 Feb. 1987
  • Mouse monoclonal antibodies specific for M and N blood group-related antigens.
    KATSUNO MAKOTO, OKAMOTO HIROAKI, TACHIBANA KATSUMI, IMAI MITSUNOBU, IKEMOTO SHIGENORI
    日本輸血学会雑誌 33(1) 21-26 Jan. 1987
  • Evaluation of the hepatitis B virus associated serological markers.
    OKAMOTO HIROAKI
    肝胆膵 13(3) 357-365 Sep. 1986
  • Hepatitis virus.
    OKAMOTO HIROAKI
    臨床成人病 16(7) 1113-1121 Jul. 1986
  • Clinical virology. 8. Virus and hepatitis.
    OKAMOTO HIROAKI, MAYUMI MAKOTO
    Medicina 23(4) 710-716 Apr. 1986
  • The production of monoclonal anti-glycophorin A and anti-glycophorin B.
    OKAMOTO HIROAKI, USUDA SADAKAZU, TACHIBANA KATSUMI, TANAKA EIJI, IKEMOTO SHIGENORI
    医学と生物学 112(3) 145-148 Mar. 1986
  • Studies on seroconversion from HBeAg to anti-HBe in asymptomatic HBV carrier children.
    FUJIMOTO TAKAKO, TAKAZAWA YOSHIE, MATSUI AKIRA, OKANIWA MARIKO, OKAMOTO HIROAKI
    肝臓 27(1) 6-14 Jan. 1986
  • Studies on seroconversion from HBeAg to anti-HBe in asymptomatic HBV carrier children.
    FUJIMOTO Takako, TAKAZAWA Yoshie, MATSUI Akira, OKANIWA Mariko, OKAMOTO Hiroaki
    Kanzo 27(1) 6-14 1986
  • Production of monoclonal anti Leb by immunization with human salivary Leb antigen.
    USUDA SADAKAZU, OKAMOTO HIROAKI, TACHIBANA KATSUMI, TANAKA EIJI, SHIMIZU MASARU, IKEMOTO SHIGENORI
    医学と生物学 111(4) 215-218 Oct. 1985
  • Normal and abnormal values. 6. Antigen-antibody. 9. HAV- and HBV-associated markers.
    OKAMOTO HIROAKI
    綜合臨床 34(Zokango) 1919-1925 Aug. 1985
  • Hepatitis A and B viruses, and .DELTA. factors.
    OKAMOTO HIROAKI
    Medicina 22(6) 978-981 Jun. 1985
  • Quantitative analysis of DNA of hepatitis B virus in sera by use of biotin labeled probes.
    TANAKA EIJI, IMAI MITSUNOBU, SHIMOZAKI MAYUMI, HOSHI YUJI, OKAMOTO HIROAKI
    肝臓 26(5) 671 May 1985
  • Production and serological characterization of mouse monoclonal anti-N hemagglutinin.
    OKAMOTO HIROAKI, USUDA SADAKAZU, TACHIBANA KATSUMI, TANAKA EIJI, IKEMOTO SHIGENORI
    医学と生物学 110(3) 149-154 Mar. 1985
  • Virus hepatitis.
    OKAMOTO HIROAKI
    生物の科学 遺伝 38(11) 49-64 Oct. 1984
  • Monoclonal anti-B hemagglutinin produced by immunization with human group B erythrocytes.
    OKAMOTO HIROAKI, USUDA SADAKAZU, TACHIBANA KATSUMI, TANAKA EIJI, IKEMOTO SHIGENORI
    医学と生物学 108(5) 251-255 May 1984
  • Monoclonal anti-H hemagglutinin produced by immunization with H substance of human salivary origin.
    OKAMOTO HIROAKI, USUDA SADAKAZU, TACHIBANA KATSUMI, TANAKA EIJI, IKEMOTO SHIGENORI
    医学と生物学 108(4) 233-236 Apr. 1984
  • Monoclonal anti-A hemagglutinin produced by immunization with group A substance of human salivary origin.
    OKAMOTO HIROAKI, USUDA SADAKAZU, TACHIBANA KATSUMI, TANAKA EIJI, IKEMOTO SHIGENORI
    医学と生物学 108(4) 219-223 Apr. 1984
  • Production of monoclonal anti Lea by immunization with human salivary Lea antigen.
    USUDA SADAKAZU, OKAMOTO HIROAKI, TACHIBANA KATSUMI, TANAKA EIJI, SHIMIZU MASARU, IKEMOTO SHIGENORI
    医学と生物学 108(4) 215-218 Apr. 1984
  • 腹部超音波検査が診断の手がかりとなった若年者肝動脈りゅうの1例
    岡本宏明, 須貝吉樹, 斎藤行世, 庄司剛彦, 畠山靖夫, 開沼康博, り好七
    肝臓 24(12) 1416-1423 Dec. 1983
  • 抗生物質の併用に関する研究 II 緑のう菌に対するCefsulodinとAminoglycosideの併用に関する基礎的・臨床的研究
    青沼清一, 大沼菊夫, 渡辺彰, 佐々木昌子, 大泉耕太郎, 今野淳, 林泉, 岡本宏明
    Chemotherapy (Tokyo) 30(7) 770-775 Jul. 1982
  • SU‐88の胃かいように対する臨床効果 併用療法
    平沢さとる, 庄司剛彦, 星野英二, 斉藤行世, 岡本宏明, 安濃栄一, 遠藤邦夫, 大みね英昭, 加ざわ徳男
    薬理と治療 10(5) 2743-2757 May 1982
  • いわ城共立病院に発生したセラチア院内感染について
    林泉, 岡本宏明, 大泉耕太郎, 佐々木昌子, 渡辺彰, 青沼清一, 大沼菊夫, 今野淳, 川名林治
    感染症学雑誌 56(2) 101-110 Feb. 1982
  • 呼吸器感染症に対するジベカシン静注法による治験 主に緑のう菌感染症に対して
    林泉, 岡本宏明
    Jpn J Antibiot 34(7) 1098-1105 Jul. 1981
  • High prevalence of hepatitis B, C, and delta virus infections among blood donors in Mongolia
    Arch Virol 150(12), 2513-2528 2005
  • Analysis of the full-length genome of hepatitis E virus isolates obtained from wild boars in Japan
    J Gen Virol 86, 3327-3336 2005
  • High prevalence of dual or triple infection of hepatitis B, C and delta viruses among patients with chronic liver disease in Mongolia
    J Med Virol 77, 491-499 2005
  • A case of acute hepatitis with positive autoantibodies who actually had hepatitis E virus infection
    Hepatol Res 32, 134-137 2005
  • Serological and molecular studies on subclinical hepatitis E virus infection using periodic serum samples from healthy individuals
    J Med Virol 76, 526-533 2005
  • Correlation between positivity for immunoglobulin A antibodies and viraemia of swine hepatitis E virus observed among farm pigs in Japan
    J Gen Virol 86, 1807-1813 2005
  • Possible risk factors for the transmission of hepatitis E virus and for the severe form of hepatitis E acquired locally in Hokkaido, Japan
    J Med Virol 76, 341-349 2005
  • High prevalence of hepatitis delta virus infection detectable by enzyme immunoassay among apparently healthy individuals in Mongolia
    J Med Virol 76, 333-340 2005
  • Evolution in the hypervariable region of the hepatitis C virus during in two infants infected by mother-to-infant transmission
    Pediatr Int 47, 278-285 2005
  • A patient with clinical features of acute hepatitis E viral infection and autoimmune hepatitis
    Tohoku J Exp Med 206, 173-179 2005
  • Risk factors for the development of hepatocellular carcinoma among patients with chronic hepatitis C who achieved a sustained virological response to interferon therapy
    J Gastroenterol Hepatol 20, 752-758 2005
  • Characterization of seven genotypes (A through E, G and H) of hepatitis B virus recovered from Japanese patients infected with human immunodeficiency virus type 1
    J Med Virol 76, 24-32 2005
  • Characterization of genotype H hepatitis B virus strain identified for the first time from a Japanese blood donor by nucleic acid amplification test
    J Gen Virol 86, 595-599 2005
  • Molecular investigation of interspousal transmission of hepatitis C virus in two Japanese patients who acquired acute hepatitis C after 40 or 42 years of marriage
    J Med Virol 75, 258-266 2005
  • Simultaneous detection of immunoglobulin A (IgA) and IgM antibodies against hepatitis E virus (HEV) is highly specific for diagnosis of acute HEV infection.
    J Clin Microbiol 43(1), 49-56 2005
  • Prevalence of hepatitis E virus (HEV) infection among hemodialysis patients in Japan: evidence for infection with a genotype 3 HEV via blood transfusion
    J Med Virol 74, 563-572 2004
  • Prevalence of hepatitis E virus (HEV) infection in wild boars and deer and genetic identification of a genotype 3 HEV from a boar in Japan
    J Clin Microbiol 42(11) 5371-5374 2004
  • Infection of a Japanese patient by genotype 4 hepatitis E virus while traveling in Vietnam
    J Clin Microbiol 42, 3883-3885 2004
  • Prevalence of antibodies to hepatitis E virus among Japanese blood donors: identification of three blood donors infected with a genotype 3 hepatitis E virus
    J Med Virol 73, 554-561 2004
  • Epidemiological and clinical study of sporadic acute hepatitis E caused by indigenous strains of hepatitis E virus in Japan compared with acute hepatitis A
    J Gastroenterol 39, 640-648 2004
  • Prevalence of antibodies to hepatitis E virus among apparently healthy humans and pigs in Bali, Indonesia: identification of a pig infected with a genotype 4 hepatitis E virus
    J Med Virol 73(1) 38-44 2004
  • Three male patients with sporadic acute hepatitis E in Sendai, Japan who were domestically infected with hepatitis E virus of genotype III or IV
    J Gastroenterol 39(3) 292-298 2004
  • High prevalence of antibodies to hepatitis A and E viruses and viremia of hepatitis B, C and D viruses among apparently healthy populations in Mongolia
    Clin Diagn Lab Immunol 11(2) 392-398 2004
  • Presence of antibodies to hepatitis E virus in Japanese pet cats
    Infection 32, 57-58 2004
  • Genetic changes in hepatitis E virus of subtype 1a in patients with sporadic acute hepatitis E in Kathmandu, Nepal, from 1997 to 2002
    J Gen Virol 85, 97-104 2004
  • Helicobacter pylori and TT virus prevalence in Japanese children
    J Gastroenterol 38, 1126-1130 2003
  • Features of hepatitis E virus infection in Japan
    Hiroaki OKAMOTO, Masaharu TAKAHASHI, Tsutomu NISHIZAWA
    Intern Med 42(11) 1065-1071 2003
  • DNA immunization of the grafted liver by particle-mediated gene gun
    Transplantation 76(9) 1369-1375 2003
  • Sporadic acute or fulminant hepatitis E in Hokkaido, Japan, may be food-borne, as suggested by the presence of hepatitis E virus in pig liver as food
    J Gen Virol 84(9) 2351-2357 2003
  • Sporadic acute hepatitis E of a 47-year-old man whose pet cat was positive for antibody to hepatitis E virus
    Hepatol Res 26(3) 237-242 2003
  • Circulating KL-6 level at baseline is a predictive indicator for the occurrence of interstitial pneumonia during interferon treatment for chronic hepatitis C
    Hepatol Res 26(2) 91-97 2003
  • Characterization of Japanese swine and human hepatitis E virus isolates of genotype IV with 99% identity over the entire genome
    J Gen Virol 84(5) 1245-1251 2003
  • Swine hepatitis E virus straisn in Japan form four phylogenetic groups comparable with those of Japanese isolates of human hepatitis E virus
    J Gen Virol 84(4) 851-862 2003
  • Identification of a genotype III swine hepatitis E virus that was isolated from a Japanese pig born in 1990 and that is most closely related to Japanese isolates of human hepatitis E virus
    J Clin Microbiol 41(3) 1342-1343 2003
  • Molecular and serological characterization of sporadic acute hepatitis E in a Japanese patient who was infected with hepatitis E virus of genotype III in 1993
    J Gen Virol 84(2) 421-427 2003
  • Molecular investigation of hepatitis E virus infection in patients with acute hepatitis in Kathmandu, Nepal
    J Med Virol 69 207-214 2003
  • Inverse relationship between the titre of TT virus DNA and the CD4 cell count in patients infected with HIV.(jointly worked)
    AIDS 15(5) 563-570 2001
  • Influence of TT virus on the histopathological features of nonalcoholic fatty liver disease.(jointly worked)
    Hepatol Res 19(3) 197-211 2001
  • Influence of TT virus on the clinical course of alcoholic liver disease.(jointly worked)
    Hepatol Res 19(2) 180-193 2001
  • IgM-class antibodies to TT virus (TTV) inpatients with acute TTV infection.(jointly worked)
    Hepatol Res 19(1) 1-11 2001
  • Visualization of TT virus particles recovered from the sera and feces of infected humans.(jointly worked)
    Biochem Biophys Res Commun 279(2) 718-724 2000
  • Transmission of human TT virus of genotype 1a to chimpanzees with fecal supernatant or serum from patients with acute TTV infection.(jointly worked)
    Biochem Biophys Res Commun 278(2) 470-476 2000
  • The entire nucleotide sequences of two distinct TT virus (TTV) isolates (TJN01 and TJN02) remotely related to the original TTV isolates.(jointly worked)
    Arch Virol 145(8) 1543-1559 2000
  • TT virus mRNAs detected in the bone marrow cells from an infected individual.(jointly worked)
    Biochem Biophys Res Commun 279(2) 700-707 2000
  • Species-specific TT viruses in humans and nonhuman primates and their phylogenetic relatedness.(jointly worked)
    Virology 277(2) 368-378 2000
  • Sequestration of TT virus of restricted genotypes in peripheral blood mononuclear cells.(jointly worked)
    J Virol 74(21) 10236-10239 2000
  • Mother-to-infant transmission of GB virus type C/HGV.(jointly worked)
    Transfusion 40 725-730 2000
  • Differentiation of hepatitis B virus genotypes D and E by ELISA using monoclonal antibodies to epitopes on the preS2-region product.(jointly worked)
    J Virol Methdos 87(1/2) 81-89 2000
  • Circular double-stranded forms of TT virus DNA in the liver.(jointly worked)
    J Virol 74(11) 5161-5167 2000
  • Replicative forms of TT virus DNA in bone marrow cells.(jointly worked)
    Biochem Biophys Res Commun 270(2) 657-662 2000
  • Species-specific TT viruses and cross-species infection in nonhuman primates.(jointly worked)
    J Virol 74(3) 1132-1139 2000
  • Frequent detection of TT virus in throat swabs of pediatric patients.(jointly worked)
    Infection 27 298 1999
  • Survey of hepatitis B virus co-infection in hepatitis C virus-infected patient suffering from chronic hepatitis and hepatocellular carcinoma.(jointly worked)
    Jpn J Cancer Res 90 1270-1272 1999
  • Contribution of hepatitis C virus to non-A, non-B, fulminant hepatitis in Japan.(jointly worked)
    Hepatology 19(4) 829-835 1999
  • Serological detection of hepatitis B virus genotypes by ELISA with monoclonal antibodies to type-specific epitopes in the preS2-region product.(jointly worked)
    J Virol Methods 80(1) 97-112 1999
  • Excretion into bile of a novel unenveloped DNA virus (TT virus) associated with acute and chronic non-A-G hepatitis.(jointly worked)
    J Infect Dis 179 1245-1248 1999
  • Determination of antibodies to virus (TTV) and application to blood donors and patients with post-transfusion non-A to G hepatitis in Japan.(jointly worked)
    J Virol Methods 77(2) 199-206 1999
  • Marked genomic heterogeneity and frequent mixed infection of TT virus demonstrated by PCR with primers from coding and noncoding regions.(jointly worked)
    Virology 259(2) 428-436 1999
  • The entire nucleotide sequence of a TT virus isolate from the United States (TUS01) : comparison with reported isolates and phylogenetic analysis.(jointly worked)
    Virology 259 437-448 1999
  • A novel unenveloped DNA virus (TT virus) associated with acute and chronic non-A to G hepatitis.(jointly worked)
    Intervirology 42(2/3) 196-204 1999
  • Distinct genotypes of a nonenveloped DNA virus associated with posttransfusion non-A to G hepatitis (TT virus) in plasma and peripheral blood mononuclear cells.(jointly worked)
    J Med Virol 57 252-258 1999
  • Ouasispecies of TT virus (TTV) with sequence divergence in hypervariable regions of the capsid protein in chronic TTV infection.(jointly worked)
    J Virol 73 9604-9608 1999
  • Influence of primers on the detection of TT Virus DNA by polymerase chain reaction.(jointly worked)
    J Infect Dis 180 1750- 1999
  • Infection by an unenveloped DNA virus associated with non-A to-G hepatitis in Japanese blood donors with or without elevated ALT levels.(jointly worked)
    Transfusion 39 522-526 1999
  • Infection with an unenveloped DNA virus (TTV) in patients with acute or chronic liver disease of unknown etiology and in those positive for hepatitis C virus RNA.(jointly worked)
    J Hepatol 30(2) 205-212 1999
  • Clinical evaluation of chronic liver diseases induced by different hepatitis C virus genotype in Japan, focused on the differences between genotypes (]G0003[)/2a and (]G0004[)/2b.(jointly worked)
    Hepatol Res 14 204-211 1999
  • The prevalence of GB virus C, risk factors and its relationship with other hepatitis viruses in a general population in Jakarta, Indonesia.(jointly worked)
    Hepatol Res 13 193-204 1999
  • Effect of interferon on a nonenveloped DNA virus (TT virus) associated with acute and chronic hepatitis of unknown etiology.(jointly worked)
    J Med Viro 58 196-200 1999
  • Hepatitis TT virus is present in New Zealand [letter].(jointly worked)
    NZ Med 111 195-196 1998
  • GB virus C/hepatitis G virus isolates in Japanese haemophiliacs and their origins.(jointly worked)
    Thromb Haemost 80(2) 242-245 1998
  • Infection with an unenveloped DNA virus (TTV) associated with posttransfusion non-A to G hepatitis in hepatitis patients and healthy blood donors in Thailand.(jointly worked)
    J Med Virol 56(3) 234-238 1998
  • Epidemiology of hepatitis C virus infection in Nepal.(jointly worked)
    Trop Gastroenterol 19 102-104 1998
  • Prevalence of anti-hepatitis C antibodies in a rural community without high mortality from liver disease in Niigata prefecture.(jointly worked)
    J Epidemiol 8 250-255 1998
  • GB virus C/hepatitis G virus infection in autoimmune liver diseases [letter].(jointly worked)
    J Gastroenterol 33(3) 463-464 1998
  • Transfusion transmitted virus [letter, comment].(jointly worked)
    Lancet 352 1310-1311 1998
  • Fecal excretion of a nonenveloped DNA virus (TTV) associated with posttransfusion non-A-G hepatitis.(jointly worked)
    J Med Virol 56(2) 128-132 1998
  • Efficacy of hepatitis B vaccines with and without preS2-region product in Sumo wrestlers in Japan.(jointly worked)
    Hepatol Res 12 3-11 1998
  • An enzyme-linked immunosorbent assay with monoclonal antibodies for the determination of phosphorylated hepatitis B core protein (p21c) in serum.(jointly worked)
    J Virol Methods 72(1) 95-103 1998
  • The entire nucleotide sequences of three hepatitis C virus isolates in genetic groups 7-9 and comparison with those in the other eight genetic groups.(jointly worked)
    J Gen Virol 79 1847-1857 1998
  • High-dose (9MU) long-term (60 weeks) alfa-interferon therapy for chronic hepatitis patients infected with HCV genotype 1b.(jointly worked)
    Arch Virol 143(8) 1545-1554 1998
  • Incidence and influence of GB virus C and hepatitis C virus infection in patients undergoing bone marrow transplantation.(jointly worked)
    Bone Marrow Transplant 21 1131-1135 1998
  • Clinical and molecular virological differences between fulminant hepatic failures following acute and chronic infection with hepatitis B virus.(jointly worked)
    J Med Virol 55(1) 35-41 1998
  • Genotypes of GB virus C and hepatitis C virus in hepatitis patients in India, Iran and Slovenia.(jointly worked)
    Hepatol Res 10 175-183 1998
  • Molecular cloning and characterization of a novel DNA virus (TTV) associated with posttransfusion hepatitis of unknown etiology.(jointly worked)
    Hepatol Res 10(1) 1-16 1998
  • A novel DNA virus (TTV) associated with elevated transaminase levels in posttransfusion hepatitis of unknown etiology.(jointly worked)
    Biochem Biophys Res Commun 241(1) 92-97 1997
  • Response to interferon of GB virus C and hepatitis C virus in patients with chronic hepatitis.(jointly worked)
    Am J Gastroenterol 92(11) 1981-1985 1997
  • Infection with GB virus C and hepatitis C virus in drug addicts, patients on maintenance hemodialysis or with chronic liver disease in Nepal.(jointly worked)
    J Med Virol 53(2) 157-161 1997
  • New HCV-like agent : epidemiology in Japan and characterization of the viral genome.(jointly worked)
    Vial hepatitis and Liver Disease. Toronto : Minerva Medica 384-386 1997
  • B cell malignancy and hepatitis C virus infection.(jointly worked)
    Leukemia 11(S3) 516-518 1997
  • High prevalence of hepatitis C virus infection in Japanese patients with porphyria cutaneatarda (letter).(jointly worked)
    Hepatology 26 246 1997
  • Mutations in the hepatitis B virus core promoter for a decreased expression of hepatitis B e antigen.(jointly worked)
    Viral hepatitis and Liver Disease. Toronto : Minerva Medica 121-126 1997
  • A novel DNA virus (TTV) associated with elevated transaminase levels in posttransfusion hepatitis of unknown etiology.(jointly worked)
    Biochem Biophys Res Commun 241(1) 92-97 1997
  • High prevalence of hepatitis C virus infection in Japanese patients with porphyria cutanea tarda [letter].(jointly worked)
    Hepatology 26(1) 246 1997
  • Response to interferon of GB virus C and hepatitis C virus in patients with chronic hepatitis.(jointly worked)
    Am J Gastroenterol 92(11) 1981-1985 1997
  • Infection with GB virus C and heaptitis C virus in drug addicts, patients on maintenance hemodialysis, or with chronic liver disease in Nepal.(jointly worked)
    J Med Virol 53(2) 157-161 1997
  • A monoclnal antibody against a hepatitis B e antigen epitope borone by six amino acids encoded by the precore region.(jointly worked)
    J Virol Methods 68(2) 207-215 1997
  • Infection with GB virus C in the patients with primary hepatocellulat carcinoma in Japan.(jointly worked)
    Hepatol Res 8 37-43 1997
  • Response to interferon-α2a in patients with e antigen-negative chtonic hepatitis B.(jointly worked)
    J Clin Gastroenterol 25(2) 440-445 1997
  • Coinfection of GB virus C with HIV-1 in Japan.(jointly worked)
    J Acquir Immune Defic Syndr Hum Retrovirul 15(4) 319-320 1997
  • Loss of circulating hepatitis C virus in children who developed a persistent carrier state after mother-to-baby transmission.(jointly worked)
    Pediatr Res 42(3) 263-267 1997
  • Molecular virology of hepatitis C virus.(jointly worked)
    Viral Hepatitis 3(1) 51-62 1997
  • Effect of interferon on GB virus C and hepatitis C virus in hepatitis patients with the co-infection.(jointly worked)
    J Med Virol 52(2) 156-160 1997
  • Impaired induction of cytotoxic T lymphocytes by antagonism of a weak agonist borne by a variant hepatitis C virus epitope.(jointly worked)
    Eur J Immunol 27(7) 1782-1787 1997
  • Infection with hepatitis G virus and its strain variant, the GB agent (GBV-C), among blood donors in Japan.(jointly worked)
    Transfusion 37 657-663 1997
  • Mutation rate of GB virus C/hepatitis G virus over the entire genome and in subgenomic regions.(jointly worked)
    Virology 233(1) 43-50 1997
  • Co-infection with GB virus C in an area of high endemicity for human Tlymphotropic virus type I in Japan.(jointly worked)
    Infection 25(2) 129-130 1997
  • GB virus C and hepatitis C virus infections in hemodialysis patients in eight Japanese centers.(jointly worked)
    Nephron 76 171-175 1997
  • The entire nucleotide sequences of two GB virus C/hepatitis G virus isolates of distinct genotypes from Japan.(jointly worked)
    J Gen Virol 78 737-745 1997
  • Cytotoxic T lymphocyte response and viral load in hepatitis C virus infection.(jointly worked)
    Hepatology 25(3) 705-712 1997
  • Infection with GB virus C and hepatitis C virus in hemodialysis patients and blood donors in Beijing.(jointly worked)
    J Med Virol 52(1) 26-30 1997
  • Infection with GB virus C in patients with chronic liver disease.(jointly worked)
    J Med Virol 51(3) 175-181 1997
  • Antibodies to hepatitis C virus and elevated transaminase levels in a town of hyper endemicity in Iwate, Japan.(jointly worked)
    J Gastroenterol Hepatol 12 67-72 1997
  • The molecular basis of hepatitis B e antigen(HBeAg)-negative infections.(jointly worked)
    J Viral Hepatitis 4(1) 1-8 1997
  • Transmission of GB virus C by blood transfusions during heart surgery.(jointly worked)
    Vox Sang 72 76-78 1997
  • Molecular investigation of GB virus C infection in hemophiliacs in Japan.(jointly worked)
    J Infect Dis 175 454-457 1997
  • Association of circulating hepatitis G virus with lipoproteins for a lack of binding with antibodies.(jointly worked)
    Biochem Biophys Res Commun 229(3) 719-725 1997
  • What is the way forward for hepatitis C virus genotypes? (jointly worked)
    GEMHEP 29-36 1997
  • Association of circulating hepatitis G virus with lipoproteins for a lack of binding with antibodies.(jointly worked)
    Biophys Biochem Res Commun 229(3) 719-725 1996
  • Infection with GB virus C (GBV-C) in patients with fulminant hepatitis.(jointly worked)
    J Hepatol 25(6) 842-847 1996
  • Hepatitis C virus genotypes and co-infection with GB virus C in patients with chronic liver disease in Jakarta, Indonesia.(jointly worked)
    Int Hepatol Commun 6 16-23 1996
  • Infection with GB virus C in female prisoners who were drug abusers in Japan (letter).(jointly worked)
    Infection 24(5) 392 1996
  • Hepatitis GB virus C (authors reply).(jointly worked)
    N Engl J Med 335 1394 1996
  • Transfusion-transmitted hepatitis G virus following open heart surgery (letter).(jointly worked)
    Transfusion 36(10) 937 1996
  • Infection with GB virus C (GBV-C) in patients with chronic liver disease or on maintenance hemodialysis in Indonesia.(jointly worked)
    J Med Virol 49(3) 248-252 1996
  • Infection with GB virus C in leprous patients in Japan.(jointly worked)
    J Med Virol 49(2) 110-114 1996
  • GBV-C in the aetiology of fulminant hepatitis (Authors' reply).(jointly worked)
    Lancet 347 120-121 1996
  • Hepatitis C virus genotypes and co-infectin with GB virus C in patients with anti-HCV-positive chronic liver disease in Jakarta, Indonesia.(jointly worked)
    Int Hepatol Commun 6(1) 16-23 1996
  • Hepatitis C virus infection in Waldenstrom's macroglobulinemia (letter).(jointly worked)
    Am J Hematol 52(3) 238-239 1996
  • B cell malignancy and hepatitis C virus infection (letter).(jointly worked)
    Leukemia Res 20(5) 445 1996
  • Prevalence of hepatitis C virus and distribution of its genotypes in Northern Eurasia.(jointly worked)
    Arch Virol 141(9) 1613-1622 1996
  • HLA DRB1 and DQB1 alleles and haplotypes influencing the progression of hepatitis C.(jointly worked)
    J Med Virol 49(4) 274-278 1996
  • Primary hepatosplenic lymphoma : association with hepatitis C virus infection (letter).(jointly worked)
    Blood 87(12) 5380-5391 1996
  • Genotyping hepatitis C virus isolates from Spain, Brazil, China, and Macau by a simplified PCR method.(jointly worked)
    J Clin Microbiol 34(10) 2372-2378 1996
  • Full-length genomic sequence of a hepatitis C virus genotype 2c isolate (BEBE1) and the 2c-specific PCR primers.(jointly worked)
    Arch Virol 141(3-4) 701-704 1996
  • Hepatitis C virus infection in patients with psoriasis (letter).(jointly worked)
    Arch Dermatol 132(11) 1391-1392 1996
  • Hepatitis C virus infection in patients with urticaria.(jointly worked)
    J Am Acad Dermatol 35 195-198 1996
  • Genotypes and multiple infections with hepatitis C virus in patients with haemophilia A in Japan.(jointly worked)
    J Viral Hepatitis 3(2) 79-84 1996
  • Cold activation of complement enhancing with the duration of storage in sera from blood donors with hepatitis C virus RNA.(jointly worked)
    Int Hepatol Commun 5(2) 89-96 1996
  • An easy dipstick assay for anti-core antibodies to screen blood donors for hepatitis C virus viremia.(jointly worked)
    Vox Sang 70(4) 229-231 1996
  • Cold activation of complement for monitoring the response to interferon in patients with chronic hepatitis C.(jointly worked)
    Am J Gastroenterol 91(2) 319-327 1996
  • Hepatitis C virus antibody, viral RNA and genotypes in leprous patients in Japan.(jointly worked)
    J Hepatol 24(4) 397-402 1996
  • Reduced precore transcription and enhanced core-pregenome transcription of hepatitis B virus DNA after replacement of the precore-core promoter with sequences associated with e antigen-seronegative persistent infections.(jointly worked)
    Virology 226(2) 269-280 1996
  • Core promoter mutations of hepatitis B virus for the response to interferon in e antigen-positive chronic hepatitis B.(jointly worked)
    Am J Gastroenterol 91(10) 2150-2156 1996
  • Mutations in the envelope gene of hepatitis B virus variants co-occurring with antibody to surface antigen in sera from patients with chronic hepatitis B.(jointly worked)
    J Gen Virol 77 1825-1831 1996
  • Infection with hepatitis GB virus among Japanese hemophiliacs.(jointly worked)
    Transfusion 36(7) 669 1996
  • Hepatitis G infection in drug abusers with chronic hepatitis C.(jointly worked)
    N Eng J Med 334(3) 195-196 1996
  • Infection with hepatitis GB virus C in patients on maintenance hemodialysis.(jointly worked)
    N Eng J Med 334(23) 1485-1490 1996
  • A second-generation method of genotyping hepatitis C virus by the polymerase chain reaction with sense and antisense primers deduced from the core gene.(jointly worked)
    J Virol Methods 57(1) 31-45 1996
  • Hepatitis C virus variants from Jakarta, Indonesia classifiable into novel genotypes in the second (2e and 2f), tenth (10a) and eleventh (11a) genetic groups.(jointly worked)
    J Gen Virol 77(2) 293-301 1996
  • HLA-B44-restricted cytotoxic T lymphocyte response to thepeptides of HCV nucleoprotein residues 81-100 in patients with chronic hepatitis C.(jointly worked)
    J Gastroenterol 30(6) 809-812 1995
  • Clearance of serum hepatitis C virus RNA after interferon therapy in relation to virus genotype.(jointly worked)
    Liver 15(4) 185-188 1995
  • HCV RNA monitoring for tailored regimens of interferon therapy in hepatitis C.(jointly worked)
    Biomed Pharmacother 49(2) 65-67 1995
  • A minimal and optimal cytotoxic T cell epitope within hepatitis C virus nucleoprotein.(jointly worked)
    J Gen Virol 76(12) 3189-3193 1995
  • Influence of the genotypes of hepatitis C virus on the severity of recurrent liver disease after liver transplantation.(jointly worked)
    Gastroenterology 108(4) 1088-1096 1995
  • Cold activation of complement as a marker of hepatitis C viremia in sera from blood donors.(jointly worked)
    Transfus Sci 16(3) 283-289 1995
  • Hepatitis C virus variants from Thailand classifiable into five novel genotypes in the sixth (6b), seventh (7c,7d) and ninth (9b,9c) major genetic groups.(jointly worked)
    J Gen Virol 76(9) 2329-2335 1995
  • Association of prurigo with hepatitis C virus infection (letter).(jointly worked)
    Arch Dermatol 131(7) 852-853 1995
  • A common-source outbreak of fulminant hepatitis B in hemodialysis patients induced by precore mutant.(jointly worked)
    Kidney Int 48 1972-1978 1995
  • A common-source outbreak of fulminant hepatitis B in hemodialysis patients induced by precore mutant.(jointly worked)
    Kidney Int 48(6) 1972-1978 1995
  • Molecular and clinical characteristics of the hepatitis C virus genotype '2c' fround in Italians in Italy and France.(jointly worked)
    Int Hepatol Commun 3(3) 161-165 1995
  • Detection of the GBV-C hepatitis virus genome in serum from patients with fulminant hepatitis of unknown aetiology.(jointly worked)
    Lancet 346(8983) 1131-1132 1995
  • Classifying hepatitis C virus genotypes.(jointly worked)
    Mol Med Today 1 20-25 1995
  • A unique set of mutations in the 'preX' region of hepatitis B virus DNA frequently found in patients but not in asymptomatic carriers : implication for a novel variant.(jointly worked)
    Int Hepatol Commun 3 131-138 1995
  • Hepatitis B virus strains with mutations in the core promoter in patients with fulminant hepatitis.(jointly worked)
    Ann Intern Med 122(4) 241-248 1995
  • Transmission of hepatitis C virus to spouses.(jointly worked)
    Ann Intern Med 122(2) 154-155 1995
  • Vertical transmission of hepatitis C virus-Reply (letter).(jointly worked)
    N Engl J Med 331(6) 400 1994
  • Prediction of interferon effect in chronic hepatitis C by both quantification and genotyping of HCV-RNA(letter).(jointly worked)
    Dig Dis Sci 39(2) 441 1994
  • Genotype of hepatitis C virus in fluminant hepatitis C (letter).(jointly worked)
    Dig Dis Sci 39(1) 220-221 1994
  • Superinfection of chimpanzees carrying hepatitis C virus of genotype II/1b with that of genotype III/2a or I/1a.(jointly worked)
    Hepatology 20(5) 1131-1136 1994
  • The entire nucleotide sequence and classification of a hepatitis C virus isolate of a novel genotype from an Indonesian patient with chronic liver disease.(jointly worked)
    J Gen Virol 75(3) 629-635 1994
  • Hepatitis B virus with mutations in the core promoter for an e antigen-negative phenotype in carriers with antibody to e antigen.(jointly worked)
    J Virol 68(12) 8102-8110 1994
  • Intrafamilial clustering of genotypes of hepatitis C virus RNA.(jointly worked)
    Acta Med Okayama 48(6) 293-297 1994
  • Hepatitis C virus variants from Vietnam are classifiable into the seventh, eigth, ane ninth major genetic groups.(jointly worked)
    Proc Nat1 Acad Sci USA 91(23) 11022-11026 1994
  • Hypocomplementemia associated with hepatitis C viremia in sera from voluntary blood donors.(jointly worked)
    Am J Gastroenterol 89(11) 2019-2024 1994
  • Hepatitis C virus infection in patients with chronic liver disease or chronic renal failure and blood donors in Thailand.(jointly worked)
    J Med Virol 44(3) 287-292 1994
  • Prompt decrease of circulating hepatitis C virus in patients with chronic hepatitis C after treatment with interferon.(jointly worked)
    J Interferon Res 14 239-244 1994
  • Influence of antibodies to the hypervariable region of E2/NS1 glycoprotein on the selective replication of hepatitis C virus in chimpanzees.(jointly worked)
    Virology 204(2) 665-672 1994
  • Hepatitis C virus RNA and antibodies among blood donors in Beijing.(jointly worked)
    J Hepatol 21(4) 634-640 1994
  • Genetic heterogeneity of hepatitis C virus.(jointly worked)
    Intervirology 37(2) 68-76 1994
  • Differences in the entire nucleotide sequence between hepatitis B virus genomes from carriers positive for antibody to hepatitis B e antigen with and without active disease.(jointly worked)
    J Med Virol 44(1) 96-103 1994
  • High rate of hepatitis C virus transmission to spouses from hepatitis patients with a history of transfusion.(jointly worked)
    Int Hepatol Commun 2(5) 250-256 1994
  • Safety and efficacy of a recombinant yeast-derived pre-S2+S-containing hepatitis B vaccine(TGP-943) : phase 1, 2 and 3 clinical testing.(jointly worked)
    Vaccine 12(12) 1090-1096 1994
  • Markers of hepatitis C and B virus infections among blood donors in Ho Chi Minh city and Hanoi, Vietnam.(jointly worked)
    Clin Diagn Lab Immunol 1(4) 413-418 1994
  • Transmission of hepatitis C virus from mothers to infants.(jointly worked)
    N Eng J Med 330(11) 744-750 1994
  • Hepatitis C and B virus infections in populations at low or high risk in Ho Chi Minh and Hanoi, Vietnam.(jointly worked)
    J Gastroenterol Hepatol 9(4) 416-419 1994
  • Entire nucleotide sequence and characterization of a hepatitis C virus of genotype V/3a.(jointly worked)
    J Gen Virol 75(7) 1761-1768 1994
  • Identification and genotyping of hepatitis C virus in injectable and oral drug users in New Zealand.(jointly worked)
    Aust NZ J Med 24(1) 47-50 1994
  • Type-specific antibodies to hepatitis C virus in patients with chronic hepatitis C for predicting response to interferon alfa.(jointly worked)
    Int Hepatol Commun 2(4) 201-206 1994
  • Hepatitis C virus antiboddies, viral RNA and genotypes in sera from patients on maintenance haemodialysis.(jointly worked)
    J Viral Hepatitis 1(1) 65-71 1994
  • Hepatitis C virus RNA in blood units with antibodies detectable by a second-generation passive hemagglutination assay, antibodies to synthetic core peptides or elevated transaminase levels.(jointly worked)
    Transfus Sci 15(1) 83-92 1994
  • Hepatitis C virus variants from Nepal with novel genotypes and their classification into the third major group.(jointly worked)
    J Gen Virol 75(4) 931-936 1994
  • Hepatitis B virus subtypes and hepatitis C virus genotypes in patients with chronic liver disease or on maintenance hemodialysis in Indonesia.(jointly worked)
    J Med virol 43(2) 182-186 1994
  • Naturally occurring escape mutants of hepatitis B virus with various mutations in the S gene in carriers seropositive for antibody to hepatitis B surface antigen.(jointly worked)
    J Virol 68(4) 2671-2676 1994
  • Hepatitis B virus subtypes and hepatitis C virus genotypes in patients with chronic liver disease in Nepal.(jointly worked)
    Hepatology 19(4) 805-809 1994
  • IgM antibody to a hepatitis C virus core peptide (CP14) for monitoring activity of liver disease in patients with acute or chronic hepatitis C.(jointly worked)
    J Med Virol 42(3) 311-317 1994
  • Genotypes and titers of hepatitis C virus for predicting response to interferon in patients with chronic hepatitis C.(jointly worked)
    J Med Virol 42(3) 299-305 1994
  • Hepatitis C virus infection in spouses of patients with type C chronic liver disease.(jointly worked)
    Ann Intern Med 12089 748-752 1994
  • Anti-preS2 neutralizes the hepatitis B virus variant with a vaccine-escape mutation at the amino acid position 126 or 145 within the S gene.(jointly worked)
    Int Hepatol Commum 2 186-189 1994
  • High carrier rate after hepatitis B virus infection in the elderly.(jointly worked)
    Hepatology 18(4) 768-774 1993
  • Recurrent fulminant hepatic failure in an HB carrier after intensive chemotherapy.(jointly worked)
    Dig Dis Sci 38(9) 1751-1755 1993
  • Genotype dependence of hepatitis C virus antibodies detectable by the first-generation enzyme-linked immunosorbent assay with C100-3 protein.(jointly worked)
    J Clin Invest 92(3) 1529-1533 1993
  • Demonstration of sugar moiety on the surface of hepatitis C virions recovered from the circulation of infected humans.(jointly worked)
    Virology 196(1) 354-357 1993
  • Chimeric hepatitis B virus core particles with parts or copies of the hepatitis C virus core protein.(jointly worked)
    J Virol 67(10) 6064-6070 1993
  • Imported hepatitis C virus genotypes in Japanese hemophiliacs.(jointly worked)
    J Infect Dis 168(1) 249-250 1993
  • A structurally flexible and antigenically variable N-terminal domain of the hepatitis C virus E2/NS1 protein : implication for an escape from antibody.(jointly worked)
    Virology 195(1) 297-301 1993
  • Prevalence, genotypes, and in isolate (HC-C2) of hepatitis C virus in chinese patients with liver disease.(jointly worked)
    J Med Virol 40(3) 254-260 1993
  • Allelic subtypic determinants of hepatitis B surface antigen (i and t) that are distinct from d/y or w/r.(jointly worked)
    J Virol 67(2) 927-932 1993
  • Characterization of the genomic sequence of type V (or 3a) hepatitis C virus isolates and PCR primers for specific detection.(jointly worked)
    J Gen Virol 74(11) 2385-2390 1993
  • Predictive value of screening tests for persistent hepatitis C virus infection evidenced by viraemia.(jointly worked)
    Vox Sang 65(3) 199-203 1993
  • Trans-complementation among naturally occurring deletion mutants of hepatitis B virus and integrated viral DNA for the production of viral particles with mutant genomes in hepatoma cell lines.(jointly worked)
    J Gen Virol 74(3) 407-414 1993
  • SDS-PAGE after micro-affinity adsorption for analysis of heterogeneous antigen polypeptides in individual sera.(jointly worked)
    J Immunol Methods 157,217-223 1993
  • Antibodies against synthetic oligopeptides deduced from the putative core gene for the diagnosis of hepatitis C virus infection.(jointly worked)
    Hepatology 15(2) 180-186 1992
  • Typing hepatitis C virus by polymerase chain reaction with type-specific primers : application to clinical surveys and tracing infectious sources.(jointly worked)
    J Gen Virol 73(3) 673-679 1992
  • Demonstration of a hepatitis C virus-specific antigen predicted from the putative core gene in the circulation of infected hosts.(jointly worked)
    J Gen Virol 73(3) 667-672 1992
  • Quantitative HCV RNA and effect of interferon therapy in chronic hepatitis C.(jointly worked)
    Dig Dis Sci 37(12) 1926-1927 1992
  • Hepatitis C virus infection in medical personnel after needlestick accident.(jointly worked)
    Hepatology 16(5) 1109-1114 1992
  • Two distinct subtypes of hepatitis C virus defined by antibodies directed to the putative core protein.(jointly worked)
    Hepatology 16(4) 886-891 1992
  • p26 protein and 33-nm particle associated with nucleocapsid of hepatitis C virus recovered from the circulation of infected hosts.(jointly worked)
    Virology 191(1) 431-434 1992
  • The degree of variability in the amino terminal region of the E2/NS1 protein of hepatitis C virus correlates with responsiveness to interferon therapy in viremic patients.(jointly worked)
    Hepatology 16(3) 619-624 1992
  • HCV genotypes in chronic hepatitis C and response to interferon (letter).(jointly worked)
    Lancet 339 1543 1992
  • HCV genotypes in China (letter).(jointly worked)
    Lancet 339 1168 1992
  • Transmission of HCV between spouses (letter).(jointly worked)
    Lancet 339 1059-1060 1992
  • Activation of hepatitis C virus following immunosuppressive treatment (letter).(jointly worked)
    Dig Dis Sci 37(3) 478 1992
  • Reactivation of precore mutant hepatitis B virus leading to fulminant hepatic failure following cytotoxic treatment.(jointly worked)
    Dig Dis Sci 37 1253-1259 1992
  • Hepatitis B surface antigen particles of subtypes adw and adr, and compound subtype (adwr) in symptom-free carriers in Japan.(jointly worked)
    J Med Virol 37(4) 288-293 1992
  • Correlation between anti-HBc titers and HBV DNA in blood units without detectable HVsAg.(jointly worked)
    Vox Sang 63(2) 107-111 1992
  • Full-length nucleotide sequence of a Japanese hepatitis C virus isolate (HC-J1) with high homology to USA isolates (letter).(jointly worked)
    Nucleic Acids Res 20(23) 6410 1992
  • Genetic drift of hepatitis C virus during an 8,2-year infection in a chimpanzee : variability and stability.(jointly worked)
    Virology 190(2) 894-899 1992
  • Mutations within the S gene of hepatitis B virus transmitted from mothers to babies immunized with hepatitis B immune globulin and vaccine.(jointly worked)
    Pediatr Res 32 264-268 1992
  • Serodiagnosis of hepatitis C virus infection by ELISA for antibodies against the putative core protein (p20c) expressed in Escherichia coli.(jointly worked)
    J Immunol Methods 148,143-150 1992
  • Full-length sequence of a hepatitis C virus genome having poor homology to reported isolates : comparative study of distinct genotypes.(jointly worked)
    Virology 188(1) 331-341 1992
  • Molecular epidemiology of hepatitis B virus in Indonesia.(jointly worked)
    J Gastroenterol Hepatol 6 491-498 1991
  • Fulminant hepatitis B : induction by hepatitis B virus mutants defective in the precore region and incapable of encoding e antigen.(jointly worked)
    Gastroenterology 100(4) 1087-2704 1991
  • Nucleotide sequence of the genomic RNA of hepatitis C virus isolated from a human carrier : comparison with reported isolatesfor conserved and divergent regions.(jointly worked)
    J Gen Virol 72(11) 2697-2704 1991
  • Persistence o HCV replication in non-A, non-B fulminant viral hepatitis (letter).(jointly worked)
    Gastroenterol Jpn 26(2) 235 1991
  • Diagnosis of type C fulminant hepatitis by the detection of antibodies to the putative core proteins of hepatitis C virus (letter).(jointly worked)
    Gastroenterol Jpn 26(2) 234 1991
  • HCV-RNA in type 2 autoimmune hepatitis (letter).(jointly worked)
    Am J Gastroenterol 86(11) 1688-1689 1991
  • Hepatitis B virus mutants with precore-region defects in two babies with fulminant hepatitis and their mothers positive for antibody to hepatitis B e antigen.(jointly worked)
    Pediatr Res 29(1) 5-9 1991
  • Posttransfusion fulminant hepatitis B associated with precore-defective HBV mutants.(jointly worked)
    Vox Sang 60(1) 34-39 1991
  • Two cases of sporadic acute hepatitis E in Mie, Japan who were infected with subgenotype 1a hepatitis E virus
    Okano Hiroshi;Maekawa Tadashi;Kobayashi Makoto;Yamawaki Makoto;Ninomiya Jun;Nakano Tatsunori;Uraki Satoko;Tanaka Hideaki;Shiraki Katsuya;Takei Yoshiyuki;Takahashi Masaharu;Okamoto Hiroaki
    Kanzo 57(2) 81-88 2016
  • Age group-dependent distribution of hepatitis C virus (HCV) serogroup and assumed transmission route in HCV-infected patients in a hospital in the Mito area
    Aikawa Tatsuya;Ueno Chisato;Kikuchi Yohko;Tsuda Fumio;Okamoto Hiroaki
    Kanzo 56(6) 303-305 2015
  • Two cases of acute hepatitis E infected with descendant strains of hepatitis E virus genotype 3 strain isolated from swine herd in Miyazaki Prefecture 12 years ago -one case had acute facial paralysis-
    NAKAMURA Masahiko;KUSUMOTO Kazunori;OCHIAI Toshimasa;KAWAGOE Tomio;TAI Hiroshi;MATSUOKA Hitoshi;NAKANO Tatsunori;NAGATA Kenji;SHIMODA Kazuya;OKAMOTO Hiroaki
    Nippon Shokakibyo Gakkai Zasshi 112(8) 1533-1541 2015
  • Direct-acting antiviral agent-resistant mutants in patients with type C chronic liver diseases: Detection and its clinical significance
    Aikawa Tatsuya;Ueno Chisato;Kikuchi Yohko;Tsuda Fumio;Ohnishi Hiroshi;Okamoto Hiroaki
    Kanzo 56(11) 621-624 2015
  • Two cases of acute hepatitis E in the same geographical area infected with different viral strains
    Morita Susumu;Yoshizawa Kaname;Uchiyama Natsuki;Fujimori Kazuya;Shigeno Takashi;Okamoto Hiroaki
    Kanzo 56(11) 625-627 2015
  • Metachronous occurrence of two cases of acute hepatitis E after eating raw pig liver and heart at the same restaurant at Gifu city in Japan
    Shimizu Shogo;Sugihara Junichi;Suzuki Yusuke;Nishigaki Yoichi;Takahashi Masaharu;Takahashi Kazuaki;Nakano Tatsunori;Hayashi Hideki;Kato Tomohiro;Tomita Eiichi;Arai Masahiro;Okamoto Hiroaki
    Kanzo 56(11) 617-620 2015

Book

  • Virus Taxonomy: Ninth Report of the International Committee on Taxonomy of Viruses
    (Joint Work )
    Elsevier Nov. 2011
  • The use of a preS2-containing recombinant vaccine for the prevention of maternal transmission of hepatitis B virus in Indonesian neonates.(jointly worked)
    Viral Hepatitis and Liver Diseases 1994
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  • Virus Taxonomy: Ninth Report of the International Committee on Taxonomy of Viruses
    (Joint Work )
    Elsevier Nov. 2011
  • The use of a preS2-containing recombinant vaccine for the prevention of maternal transmission of hepatitis B virus in Indonesian neonates.(jointly worked)
    Viral Hepatitis and Liver Diseases 1994

Prize

  • 1992 Nikkei BP Technology Award,
  • 1997 Oda Prize,
  • 2000 ISI Citation Laureate Award,
  • 2008 Saburo Kojima Memorial Award,
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  • 1992 Nikkei BP Technology Award,
  • 1997 Oda Prize,
  • 2000 ISI Citation Laureate Award,
  • 2008 Saburo Kojima Memorial Award,

Outside Fund Adoption

  • Molecular biology and epidemiology of hepatitis viruses
    Project Year :1983
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  • Molecular biology and epidemiology of hepatitis viruses
    Project Year :1983


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