mizukami hiroaki

FacultyCenterforMolelucarMedicine(DivisionofGeneticTherapeutics)
Job titleProfessorWeb site

Profile

Research Keywords

    Hematology, Virology, Molecular Biology

Research Areas

  • Clinical internal medicine / General internal medicine (including psychosomatic medicine)

Career

  • Jichi Medical University, Professor
  • Associate
  • emergency medical corp. JSDF Hospital Yokosuka
  • 1993
    -
    1995
    National Institutes of Health, Visiting
  • 1995
    -
    1998
    Chief academic administrater. school for

Research Activities

Papers(paper)

  • DNA methylation and methyl-binding proteins control differential gene expression in distinct cortical areas of macaque monkey.
    Hata K, Mizukami H, Sadakane O, Watakabe A, Ohtsuka M, Takaji M, Kinoshita M, Isa T, Ozawa K, Yamamori T
    The Journal of neuroscience : the official journal of the Society for Neuroscience 33 19704-19714 Dec. 2013
  • Oxytocin receptor in the hypothalamus is sufficient to rescue normal thermoregulatory function in male oxytocin receptor knockout mice.
    Kasahara Y, Sato K, Takayanagi Y, Mizukami H, Ozawa K, Hidema S, So KH, Kawada T, Inoue N, Ikeda I, Roh SG, Itoi K, Nishimori K
    Endocrinology 154 4305-4315 Nov. 2013
  • The prevalence of neutralizing antibodies against adeno-associated virus capsids is reduced in young Japanese individuals.
    Mimuro J, Mizukami H, Shima M, Matsushita T, Taki M, Muto S, Higasa S, Sakai M, Ohmori T, Madoiwa S, Ozawa K, Sakata Y
    Journal of medical virology Oct. 2013
  • Novel anti-tumor mechanism of galanin receptor type 2 in head and neck squamous cell carcinoma cells.
    Uehara T, Kanazawa T, Mizukami H, Uchibori R, Tsukahara T, Urabe M, Kume A, Misawa K, Carey TE, Suzuki M, Ichimura K, Ozawa K
    Cancer science Oct. 2013
  • Fear-enhancing effects of septal oxytocin receptors.
    Guzmán YF, Tronson NC, Jovasevic V, Sato K, Guedea AL, Mizukami H, Nishimori K, Radulovic J
    Nature neuroscience 16 1185-1187 Sep. 2013
  • Suppression of lymph node and lung metastases of endometrial cancer by muscle-mediated expression of soluble vascular endothelial growth factor receptor-3.
    Takahashi K, Mizukami H, Saga Y, Takei Y, Urabe M, Kume A, Machida S, Fujiwara H, Suzuki M, Ozawa K
    Cancer science 104 1107-1111 Aug. 2013
  • CD19 target-engineered T-cells accumulate at tumor lesions in human B-cell lymphoma xenograft mouse models.
    Tsukahara T, Ohmine K, Yamamoto C, Uchibori R, Ido H, Teruya T, Urabe M, Mizukami H, Kume A, Nakamura M, Mineno J, Takesako K, Riviere I, Sadelain M, Brentjens R, Ozawa K
    Biochemical and biophysical research communications 438 84-89 Aug. 2013
  • Overexpression of factor VII ameliorates bleeding diathesis of factor VIII-deficient mice with inhibitors.
    Yasumoto A, Madoiwa S, Kashiwakura Y, Ishiwata A, Ohmori T, Mizukami H, Ozawa K, Sakata Y, Mimuro J
    Thrombosis research 131 444-449 May 2013
  • Minimizing the inhibitory effect of neutralizing antibody for efficient gene expression in the liver with adeno-associated virus 8 vectors.
    Mimuro J, Mizukami H, Hishikawa S, Ikemoto T, Ishiwata A, Sakata A, Ohmori T, Madoiwa S, Ono F, Ozawa K, Sakata Y
    Molecular therapy : the journal of the American Society of Gene Therapy 21 318-323 Feb. 2013
  • NF-κB activity regulates mesenchymal stem cell accumulation at tumor sites.
    Uchibori R, Tsukahara T, Mizuguchi H, Saga Y, Urabe M, Mizukami H, Kume A, Ozawa K
    Cancer research 73 364-372 Jan. 2013
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Papers(paper)close
  • DNA methylation and methyl-binding proteins control differential gene expression in distinct cortical areas of macaque monkey.
    Hata K, Mizukami H, Sadakane O, Watakabe A, Ohtsuka M, Takaji M, Kinoshita M, Isa T, Ozawa K, Yamamori T
    The Journal of neuroscience : the official journal of the Society for Neuroscience 33 19704-19714 Dec. 2013
  • Oxytocin receptor in the hypothalamus is sufficient to rescue normal thermoregulatory function in male oxytocin receptor knockout mice.
    Kasahara Y, Sato K, Takayanagi Y, Mizukami H, Ozawa K, Hidema S, So KH, Kawada T, Inoue N, Ikeda I, Roh SG, Itoi K, Nishimori K
    Endocrinology 154 4305-4315 Nov. 2013
  • The prevalence of neutralizing antibodies against adeno-associated virus capsids is reduced in young Japanese individuals.
    Mimuro J, Mizukami H, Shima M, Matsushita T, Taki M, Muto S, Higasa S, Sakai M, Ohmori T, Madoiwa S, Ozawa K, Sakata Y
    Journal of medical virology Oct. 2013
  • Novel anti-tumor mechanism of galanin receptor type 2 in head and neck squamous cell carcinoma cells.
    Uehara T, Kanazawa T, Mizukami H, Uchibori R, Tsukahara T, Urabe M, Kume A, Misawa K, Carey TE, Suzuki M, Ichimura K, Ozawa K
    Cancer science Oct. 2013
  • Fear-enhancing effects of septal oxytocin receptors.
    Guzmán YF, Tronson NC, Jovasevic V, Sato K, Guedea AL, Mizukami H, Nishimori K, Radulovic J
    Nature neuroscience 16 1185-1187 Sep. 2013
  • Suppression of lymph node and lung metastases of endometrial cancer by muscle-mediated expression of soluble vascular endothelial growth factor receptor-3.
    Takahashi K, Mizukami H, Saga Y, Takei Y, Urabe M, Kume A, Machida S, Fujiwara H, Suzuki M, Ozawa K
    Cancer science 104 1107-1111 Aug. 2013
  • CD19 target-engineered T-cells accumulate at tumor lesions in human B-cell lymphoma xenograft mouse models.
    Tsukahara T, Ohmine K, Yamamoto C, Uchibori R, Ido H, Teruya T, Urabe M, Mizukami H, Kume A, Nakamura M, Mineno J, Takesako K, Riviere I, Sadelain M, Brentjens R, Ozawa K
    Biochemical and biophysical research communications 438 84-89 Aug. 2013
  • Overexpression of factor VII ameliorates bleeding diathesis of factor VIII-deficient mice with inhibitors.
    Yasumoto A, Madoiwa S, Kashiwakura Y, Ishiwata A, Ohmori T, Mizukami H, Ozawa K, Sakata Y, Mimuro J
    Thrombosis research 131 444-449 May 2013
  • Minimizing the inhibitory effect of neutralizing antibody for efficient gene expression in the liver with adeno-associated virus 8 vectors.
    Mimuro J, Mizukami H, Hishikawa S, Ikemoto T, Ishiwata A, Sakata A, Ohmori T, Madoiwa S, Ono F, Ozawa K, Sakata Y
    Molecular therapy : the journal of the American Society of Gene Therapy 21 318-323 Feb. 2013
  • NF-κB activity regulates mesenchymal stem cell accumulation at tumor sites.
    Uchibori R, Tsukahara T, Mizuguchi H, Saga Y, Urabe M, Mizukami H, Kume A, Ozawa K
    Cancer research 73 364-372 Jan. 2013
  • Prophylaxis and treatment of Alzheimer's disease by delivery of an adeno-associated virus encoding a monoclonal antibody targeting the amyloid Beta protein.
    Shimada M, Abe S, Takahashi T, Shiozaki K, Okuda M, Mizukami H, Klinman DM, Ozawa K, Okuda K
    PloS one 8 e57606 2013
  • An R132H mutation in isocitrate dehydrogenase 1 enhances p21 expression and inhibits phosphorylation of retinoblastoma protein in glioma cells.
    Miyata S, Urabe M, Gomi A, Nagai M, Yamaguchi T, Tsukahara T, Mizukami H, Kume A, Ozawa K, Watanabe E
    Neurologia medico-chirurgica 53 645-654 2013
  • Downregulation of indoleamine-2,3-dioxygenase in cervical cancer cells suppresses tumor growth by promoting natural killer cell accumulation.
    Sato N, Saga Y, Mizukami H, Wang D, Takahashi S, Nonaka H, Fujiwara H, Takei Y, Machida S, Takikawa O, Ozawa K, Suzuki M
    Oncology reports 28 1574-1578 Nov. 2012
  • Cetuximab inhibits the growth of mucinous ovarian carcinoma tumor cells lacking KRAS gene mutations.
    Sato N, Saga Y, Mizukami H, Wang D, Fujiwara H, Takei Y, Machida S, Ozawa K, Suzuki M
    Oncology reports 27 1336-1340 May 2012
  • Indoleamine-2,3-dioxygenase, an immunosuppressive enzyme that inhibits natural killer cell function, as a useful target for ovarian cancer therapy.
    Wang D, Saga Y, Mizukami H, Sato N, Nonaka H, Fujiwara H, Takei Y, Machida S, Takikawa O, Ozawa K, Suzuki M
    International journal of oncology 40 929-934 Apr. 2012
  • Recovery of neurogenic amines in phenylketonuria mice after liver-targeted gene therapy.
    Yagi H, Sanechika S, Ichinose H, Sumi-Ichinose C, Mizukami H, Urabe M, Ozawa K, Kume A
    Neuroreport 23 30-34 Jan. 2012
  • Efficient establishment of pig embryonic fibroblast cell lines with conditional expression of the simian vacuolating virus 40 large T fragment.
    Fukuda T, Katayama M, Yoshizawa T, Eitsuka T, Mizukami H, Nakagawa K, Ito H, Komagata H, Song S, Roh S, Hoshino Y, Sato E, Hanada H, Nishimori K, Miyazawa T, Uchida T
    Bioscience, biotechnology, and biochemistry 76 1372-1377 2012
  • Development of a mouse model for lymph node metastasis with endometrial cancer.
    Takahashi K, Saga Y, Mizukami H, Takei Y, Urabe M, Kume A, Suzuki M, Ozawa K
    Cancer science 102 2272-2277 Dec. 2011
  • Selective optical control of synaptic transmission in the subcortical visual pathway by activation of viral vector-expressed halorhodopsin.
    Kaneda K, Kasahara H, Matsui R, Katoh T, Mizukami H, Ozawa K, Watanabe D, Isa T
    PloS one 6 e18452 Apr. 2011
  • Complete restoration of phenylalanine oxidation in phenylketonuria mouse by a self-complementary adeno-associated virus vector.
    Yagi H, Ogura T, Mizukami H, Urabe M, Hamada H, Yoshikawa H, Ozawa K, Kume A
    The journal of gene medicine 13 114-122 Feb. 2011
  • Characterization of a recombinant adeno-associated virus type 2 Reference Standard Material.
    Lock M, McGorray S, Auricchio A, Ayuso E, Beecham EJ, Blouin-Tavel V, Bosch F, Bose M, Byrne BJ, Caton T, Chiorini JA, Chtarto A, Clark KR, Conlon T, Darmon C, Doria M, Douar A, Flotte TR, Francis JD, Francois A, Giacca M, Korn MT, Korytov I, Leon X, Leuchs B, Lux G, Melas C, Mizukami H, Moullier P, Müller M, Ozawa K, Philipsberg T, Poulard K, Raupp C, Rivière C, Roosendaal SD, Samulski RJ, Soltys SM, Surosky R, Tenenbaum L, Thomas DL, van Montfort B, Veres G, Wright JF, Xu Y, Zelenaia O, Zentilin L, Snyder RO
    Human gene therapy 21 1273-1285 Oct. 2010
  • A phase I study of aromatic L-amino acid decarboxylase gene therapy for Parkinson's disease.
    Muramatsu S, Fujimoto K, Kato S, Mizukami H, Asari S, Ikeguchi K, Kawakami T, Urabe M, Kume A, Sato T, Watanabe E, Ozawa K, Nakano I
    Molecular therapy : the journal of the American Society of Gene Therapy 18 1731-1735 Sep. 2010
  • Mutant macaque factor IX T262A: a tool for hemophilia B gene therapy studies in macaques.
    Ishiwata A, Mimuro J, Mizukami H, Kashiwakura Y, Yasumoto A, Sakata A, Ohmori T, Madoiwa S, Ono F, Shima M, Yoshioka A, Ozawa K, Sakata Y
    Thrombosis research 125 533-537 Jun. 2010
  • A convenient enzyme-linked immunosorbent assay for rapid screening of anti-adeno-associated virus neutralizing antibodies.
    Ito T, Yamamoto S, Hayashi T, Kodera M, Mizukami H, Ozawa K, Muramatsu S
    Annals of clinical biochemistry 46 508-510 Nov. 2009
  • Liver-restricted expression of the canine factor VIII gene facilitates prevention of inhibitor formation in factor VIII-deficient mice.
    Ishiwata A, Mimuro J, Mizukami H, Kashiwakura Y, Takano K, Ohmori T, Madoiwa S, Ozawa K, Sakata Y
    The journal of gene medicine 11 1020-1029 Nov. 2009
  • The cardiac pacemaker-specific channel Hcn4 is a direct transcriptional target of MEF2.
    Kuratomi S, Ohmori Y, Ito M, Shimazaki K, Muramatsu S, Mizukami H, Uosaki H, Yamashita JK, Arai Y, Kuwahara K, Takano M
    Cardiovascular research 83 682-687 Sep. 2009
  • Generation of adeno-associated virus vector enabling functional expression of oxytocin receptor and fluorescence marker genes using the human eIF4G internal ribosome entry site element.
    Sato K, Date S, Aoyagi Y, Kasahara Y, Nawa A, Mizukami H, Hidema S, Ozawa K, Nishimori K
    Bioscience, biotechnology, and biochemistry 73 2145-2148 Sep. 2009
  • Retroviral vector-producing mesenchymal stem cells for targeted suicide cancer gene therapy.
    Uchibori R, Okada T, Ito T, Urabe M, Mizukami H, Kume A, Ozawa K
    The journal of gene medicine 11 373-381 May 2009
  • Cell and gene therapy using mesenchymal stem cells (MSCs).
    Ozawa K, Sato K, Oh I, Ozaki K, Uchibori R, Obara Y, Kikuchi Y, Ito T, Okada T, Urabe M, Mizukami H, Kume A
    Journal of autoimmunity 30 121-127 May 2008
  • Adeno-associated virus vector-mediated systemic interleukin-10 expression ameliorates hypertensive organ damage in Dahl salt-sensitive rats.
    Nonaka-Sarukawa M, Okada T, Ito T, Yamamoto K, Yoshioka T, Nomoto T, Hojo Y, Shimpo M, Urabe M, Mizukami H, Kume A, Ikeda U, Shimada K, Ozawa K
    The journal of gene medicine 10 368-374 Apr. 2008
  • Protection against aminoglycoside-induced ototoxicity by regulated AAV vector-mediated GDNF gene transfer into the cochlea.
    Liu Y, Okada T, Shimazaki K, Sheykholeslami K, Nomoto T, Muramatsu S, Mizukami H, Kume A, Xiao S, Ichimura K, Ozawa K
    Molecular therapy : the journal of the American Society of Gene Therapy 16 474-480 Mar. 2008
  • Adeno-associated virus vector-mediated production of hepatocyte growth factor attenuates liver fibrosis in mice.
    Suzumura K, Hirano T, Son G, Iimuro Y, Mizukami H, Ozawa K, Fujimoto J
    Hepatology international 2 80-88 Mar. 2008
  • Overexpression of PTEN in ovarian cancer cells suppresses i.p. dissemination and extends survival in mice.
    Takei Y, Saga Y, Mizukami H, Takayama T, Ohwada M, Ozawa K, Suzuki M
    Molecular cancer therapeutics 7 704-711 Mar. 2008
  • Interleukin-10 expression mediated by an adeno-associated virus vector prevents monocrotaline-induced pulmonary arterial hypertension in rats.
    Ito T, Okada T, Miyashita H, Nomoto T, Nonaka-Sarukawa M, Uchibori R, Maeda Y, Urabe M, Mizukami H, Kume A, Takahashi M, Ikeda U, Shimada K, Ozawa K
    Circulation research 101 734-741 Sep. 2007
  • Suppression of ovarian cancer by muscle-mediated expression of soluble VEGFR-1/Flt-1 using adeno-associated virus serotype 1-derived vector.
    Takei Y, Mizukami H, Saga Y, Yoshimura I, Hasumi Y, Takayama T, Kohno T, Matsushita T, Okada T, Kume A, Suzuki M, Ozawa K
    International journal of cancer. Journal international du cancer 120 278-284 Jan. 2007
  • Prevention of diabetic retinopathy by intraocular soluble flt-1 gene transfer in a spontaneously diabetic rat model.
    Ideno J, Mizukami H, Kakehashi A, Saito Y, Okada T, Urabe M, Kume A, Kuroki M, Kawakami M, Ishibashi S, Ozawa K
    International journal of molecular medicine 19 75-79 Jan. 2007
  • Tendon healing in vitro: adeno-associated virus-2 effectively transduces intrasynovial tenocytes with persistent expression of the transgene, but other serotypes do not.
    Wang XT, Liu PY, Tang JB, Mizukami H, Xin KQ, Ozawa K, Ushijima H
    Plastic and reconstructive surgery 119 227-234 Jan. 2007
  • Induction of robust immune responses against human immunodeficiency virus is supported by the inherent tropism of adeno-associated virus type 5 for dendritic cells.
    Xin KQ, Mizukami H, Urabe M, Toda Y, Shinoda K, Yoshida A, Oomura K, Kojima Y, Ichino M, Klinman D, Ozawa K, Okuda K
    Journal of virology 80 11899-11910 Dec. 2006
  • Adipose tissue as a novel target for in vivo gene transfer by adeno-associated viral vectors.
    Mizukami H, Mimuro J, Ogura T, Okada T, Urabe M, Kume A, Sakata Y, Ozawa K
    Human gene therapy 17 921-928 Sep. 2006
  • Utility of intraperitoneal administration as a route of AAV serotype 5 vector-mediated neonatal gene transfer.
    Ogura T, Mizukami H, Mimuro J, Madoiwa S, Okada T, Matsushita T, Urabe M, Kume A, Hamada H, Yoshikawa H, Sakata Y, Ozawa K
    The journal of gene medicine 8 990-997 Aug. 2006
  • A histone deacetylase inhibitor enhances recombinant adeno-associated virus-mediated gene expression in tumor cells.
    Okada T, Uchibori R, Iwata-Okada M, Takahashi M, Nomoto T, Nonaka-Sarukawa M, Ito T, Liu Y, Mizukami H, Kume A, Kobayashi E, Ozawa K
    Molecular therapy : the journal of the American Society of Gene Therapy 13 738-746 Apr. 2006
  • Removal of empty capsids from type 1 adeno-associated virus vector stocks by anion-exchange chromatography potentiates transgene expression.
    Urabe M, Xin KQ, Obara Y, Nakakura T, Mizukami H, Kume A, Okuda K, Ozawa K
    Molecular therapy : the journal of the American Society of Gene Therapy 13 823-828 Apr. 2006
  • Scalable generation of high-titer recombinant adeno-associated virus type 5 in insect cells.
    Urabe M, Nakakura T, Xin KQ, Obara Y, Mizukami H, Kume A, Kotin RM, Ozawa K
    Journal of virology 80 1874-1885 Feb. 2006
  • Phenotype correction of hemophilia A mice with adeno-associated virus vectors carrying the B domain-deleted canine factor VIII gene.
    Ishiwata A, Mimuro J, Kashiwakura Y, Niimura M, Takano K, Ohmori T, Madoiwa S, Mizukami H, Okada T, Naka H, Yoshioka A, Ozawa K, Sakata Y
    Thrombosis research 118 627-635 2006
  • Repair of articular cartilage defect by intraarticular administration of basic fibroblast growth factor gene, using adeno-associated virus vector.
    Hiraide A, Yokoo N, Xin KQ, Okuda K, Mizukami H, Ozawa K, Saito T
    Human gene therapy 16 1413-1421 Dec. 2005
  • Specific and efficient transduction of Cochlear inner hair cells with recombinant adeno-associated virus type 3 vector.
    Liu Y, Okada T, Sheykholeslami K, Shimazaki K, Nomoto T, Muramatsu S, Kanazawa T, Takeuchi K, Ajalli R, Mizukami H, Kume A, Ichimura K, Ozawa K
    Molecular therapy : the journal of the American Society of Gene Therapy 12 725-733 Oct. 2005
  • Large-scale production of recombinant viruses by use of a large culture vessel with active gassing.
    Okada T, Nomoto T, Yoshioka T, Nonaka-Sarukawa M, Ito T, Ogura T, Iwata-Okada M, Uchibori R, Shimazaki K, Mizukami H, Kume A, Ozawa K
    Human gene therapy 16 1212-1218 Oct. 2005
  • Cerebrospinal fluid neprilysin is reduced in prodromal Alzheimer's disease.
    Maruyama M, Higuchi M, Takaki Y, Matsuba Y, Tanji H, Nemoto M, Tomita N, Matsui T, Iwata N, Mizukami H, Muramatsu S, Ozawa K, Saido TC, Arai H, Sasaki H
    Annals of neurology 57 832-842 Jun. 2005
  • Overexpression of a hybrid gene consisting of the amino-terminal fragment of urokinase and carboxyl-terminal domain of bikunin suppresses invasion and migration of human ovarian cancer cells in vitro.
    Takei Y, Mizukami H, Saga Y, Kobayashi H, Suzuki M, Matsushita T, Ozawa K, Suzuki M
    International journal of cancer. Journal international du cancer 113 54-58 Jan. 2005
  • Repair of articular cartilage defect by autologous transplantation of basic fibroblast growth factor gene-transduced chondrocytes with adeno-associated virus vector.
    Yokoo N, Saito T, Uesugi M, Kobayashi N, Xin KQ, Okuda K, Mizukami H, Ozawa K, Koshino T
    Arthritis and rheumatism 52 164-170 Jan. 2005
  • Sustained transgene expression by human cord blood derived CD34+ cells transduced with simian immunodeficiency virus agmTYO1-based vectors carrying the human coagulation factor VIII gene in NOD/SCID mice.
    Kikuchi J, Mimuro J, Ogata K, Tabata T, Ueda Y, Ishiwata A, Kimura K, Takano K, Madoiwa S, Mizukami H, Hanazono Y, Kume A, Hasegawa M, Ozawa K, Sakata Y
    The journal of gene medicine 6 1049-1060 Oct. 2004
  • Topoisomerase inhibitors enhance the cytocidal effect of AAV-HSVtk/ganciclovir on head and neck cancer cells.
    Kanazawa T, Mizukami H, Nishino H, Okada T, Hanazono Y, Kume A, Kitamura K, Ichimura K, Ozawa K
    International journal of oncology 25 729-735 Sep. 2004
  • The adenovirus E1A and E1B19K genes provide a helper function for transfection-based adeno-associated virus vector production.
    Matsushita T, Okada T, Inaba T, Mizukami H, Ozawa K, Colosi P
    The Journal of general virology 85 2209-2214 Aug. 2004
  • Is fenestration a safe treatment for adult polycystic liver disease?: A report of refractory complications.
    Ishibashi K, Midorikawa T, Kikuchi H, Fujiwara Y, Izuno H, Hatakeyama T, Saito M, Miyakawa K, Mizukami H, Maezawa K, Nemoto H, Sanada Y
    Hepato-gastroenterology 51 1165-1167 Jul. 2004
  • Separate control of Rep and Cap expression using mutant and wild-type loxP sequences and improved packaging system for adeno-associated virus vector production.
    Mizukami H, Okada T, Ogasawara Y, Matsushita T, Urabe M, Kume A, Ozawa K
    Molecular biotechnology 27 7-14 May 2004
  • Presynaptic localization of neprilysin contributes to efficient clearance of amyloid-beta peptide in mouse brain.
    Iwata N, Mizukami H, Shirotani K, Takaki Y, Muramatsu S, Lu B, Gerard NP, Gerard C, Ozawa K, Saido TC
    The Journal of neuroscience : the official journal of the Society for Neuroscience 24 991-998 Jan. 2004
  • Successful gene transfer using adeno-associated virus vectors into the kidney: comparison among adeno-associated virus serotype 1-5 vectors in vitro and in vivo.
    Takeda S, Takahashi M, Mizukami H, Kobayashi E, Takeuchi K, Hakamata Y, Kaneko T, Yamamoto H, Ito C, Ozawa K, Ishibashi K, Matsuzaki T, Takata K, Asano Y, Kusano E
    Nephron. Experimental nephrology 96 e119-26 2004
  • Persistent phenotypic correction of central diabetes insipidus using adeno-associated virus vector expressing arginine-vasopressin in Brattleboro rats.
    Ideno J, Mizukami H, Honda K, Okada T, Hanazono Y, Kume A, Saito T, Ishibashi S, Ozawa K
    Molecular therapy : the journal of the American Society of Gene Therapy 8 895-902 Dec. 2003
  • A soluble CAR-SCF fusion protein improves adenoviral vector-mediated gene transfer to c-Kit-positive hematopoietic cells.
    Itoh A, Okada T, Mizuguchi H, Hayakawa T, Mizukami H, Kume A, Takatoku M, Komatsu N, Hanazono Y, Ozawa K
    The journal of gene medicine 5 929-940 Nov. 2003
  • Suppression of cell migration in ovarian cancer cells mediated by PTEN overexpression.
    Saga Y, Mizukami H, Takei Y, Ozawa K, Suzuki M
    International journal of oncology 23 1109-1113 Oct. 2003
  • Overexpression of thymidylate synthase mediates desensitization for 5-fluorouracil of tumor cells.
    Saga Y, Suzuki M, Mizukami H, Kohno T, Takei Y, Fukushima M, Ozawa K
    International journal of cancer. Journal international du cancer 106 324-326 Sep. 2003
  • Interleukin-10-mediated inhibition of angiogenesis and tumor growth in mice bearing VEGF-producing ovarian cancer.
    Kohno T, Mizukami H, Suzuki M, Saga Y, Takei Y, Shimpo M, Matsushita T, Okada T, Hanazono Y, Kume A, Sato I, Ozawa K
    Cancer research 63 5091-5094 Aug. 2003
  • Reduction of CTLL-2 cytotoxicity by induction of apoptosis with a Fas-estrogen receptor chimera.
    Kametaka M, Kume A, Okada T, Mizukami H, Hanazono Y, Ozawa K
    Cancer science 94 639-643 Jul. 2003
  • A DNA vaccine containing inverted terminal repeats from adeno-associated virus increases immunity to HIV.
    Xin KQ, Ooki T, Jounai N, Mizukami H, Hamajima K, Kojima Y, Ohba K, Toda Y, Hirai S, Klinman DM, Ozawa K, Okuda K
    The journal of gene medicine 5 438-445 May 2003
  • Distinct patterns of gene transfer to gerbil hippocampus with recombinant adeno-associated virus type 2 and 5.
    Nomoto T, Okada T, Shimazaki K, Mizukami H, Matsushita T, Hanazono Y, Kume A, Katsura K, Katayama Y, Ozawa K
    Neuroscience letters 340 153-157 Apr. 2003
  • In vivo expansion of transduced murine hematopoietic cells with a selective amplifier gene.
    Kume A, Koremoto M, Xu R, Okada T, Mizukami H, Hanazono Y, Hasegawa M, Ozawa K
    The journal of gene medicine 5 175-181 Mar. 2003
  • Intramuscular injection of AAV-GDNF results in sustained expression of transgenic GDNF, and its delivery to spinal motoneurons by retrograde transport.
    Lu YY, Wang LJ, Muramatsu S, Ikeguchi K, Fujimoto K, Okada T, Mizukami H, Matsushita T, Hanazono Y, Kume A, Nagatsu T, Ozawa K, Nakano I
    Neuroscience research 45 33-40 Jan. 2003
  • Selective expansion of transduced cells for hematopoietic stem cell gene therapy.
    Kume A, Hanazono Y, Mizukami H, Okada T, Ozawa K
    International journal of hematology 76 299-304 Nov. 2002
  • Gene marking in adeno-associated virus vector infected periosteum derived cells for cartilage repair.
    Kobayashi N, Koshino T, Uesugi M, Yokoo N, Xin KQ, Okuda K, Mizukami H, Ozawa K, Saito T
    The Journal of rheumatology 29 2176-2180 Oct. 2002
  • Adeno-associated virus vectors for gene transfer to the brain.
    Okada T, Nomoto T, Shimazaki K, Lijun W, Lu Y, Matsushita T, Mizukami H, Urabe M, Hanazono Y, Kume A, Muramatsu S, Nakano I, Ozawa K
    Methods (San Diego, Calif.) 28 237-247 Oct. 2002
  • Oral administration of recombinant adeno-associated virus elicits human immunodeficiency virus-specific immune responses.
    Xin KQ, Ooki T, Mizukami H, Hamajima K, Okudela K, Hashimoto K, Kojima Y, Jounai N, Kumamoto Y, Sasaki S, Klinman D, Ozawa K, Okuda K
    Human gene therapy 13 1571-1581 Sep. 2002
  • Neuroprotective effects of glial cell line-derived neurotrophic factor mediated by an adeno-associated virus vector in a transgenic animal model of amyotrophic lateral sclerosis.
    Wang LJ, Lu YY, Muramatsu S, Ikeguchi K, Fujimoto K, Okada T, Mizukami H, Matsushita T, Hanazono Y, Kume A, Nagatsu T, Ozawa K, Nakano I
    The Journal of neuroscience : the official journal of the Society for Neuroscience 22 6920-6928 Aug. 2002
  • Overexpression of PTEN increases sensitivity to SN-38, an active metabolite of the topoisomerase I inhibitor irinotecan, in ovarian cancer cells.
    Saga Y, Mizukami H, Suzuki M, Kohno T, Urabe M, Ozawa K, Sato I
    Clinical cancer research : an official journal of the American Association for Cancer Research 8 1248-1252 May 2002
  • Soluble FLT-1 expression suppresses carcinomatous ascites in nude mice bearing ovarian cancer.
    Hasumi Y, Mizukami H, Urabe M, Kohno T, Takeuchi K, Kume A, Momoeda M, Yoshikawa H, Tsuruo T, Shibuya M, Taketani Y, Ozawa K
    Cancer research 62 2019-2023 Apr. 2002
  • AAV-mediated VEGF gene transfer into skeletal muscle stimulates angiogenesis and improves blood flow in a rat hindlimb ischemia model.
    Shimpo M, Ikeda U, Maeda Y, Takahashi M, Miyashita H, Mizukami H, Urabe M, Kume A, Takizawa T, Shibuya M, Ozawa K, Shimada K
    Cardiovascular research 53 993-1001 Mar. 2002
  • Behavioral recovery in a primate model of Parkinson's disease by triple transduction of striatal cells with adeno-associated viral vectors expressing dopamine-synthesizing enzymes.
    Muramatsu S, Fujimoto K, Ikeguchi K, Shizuma N, Kawasaki K, Ono F, Shen Y, Wang L, Mizukami H, Kume A, Matsumura M, Nagatsu I, Urano F, Ichinose H, Nagatsu T, Terao K, Nakano I, Ozawa K
    Human gene therapy 13 345-354 Feb. 2002
  • Adeno-associated viral vector-mediated gene therapy of ischemia-induced neuronal death.
    Okada T, Shimazaki K, Nomoto T, Matsushita T, Mizukami H, Urabe M, Hanazono Y, Kume A, Tobita K, Ozawa K, Kawai N
    Methods in enzymology 346 378-393 2002
  • Enhanced expression of thymidylate synthase mediates resistance of uterine cervical cancer cells to radiation.
    Saga Y, Suzuki M, Mizukami H, Urabe M, Fukushima M, Ozawa K, Sato I
    Oncology 63 185-191 2002

Papers(other)

  • Adeno-associated virus type2 binds to a 150-kilodalton cell membrane glycoprotein.(共著)
    Virology 217(1) 124-130 1996
  • Nucleotide Sequencing and generation of an infectious clone of adeno-associated Virus 3. (共著)
    Virology 221(1) 208-217 1996
  • Leukemia linked to eating disorders. (共著)
    British Medical Journal. 306 830-831 1993
  • Granulocyte colony stimulating factor-producing malignant lymphoma. (共著)
    acta Hematologica 87 156-159 1992
  • Elevated neutrophil function inchronic neutrophilic leukemia. (共著)
    American Journal of Hematology 41 50-56 1992
  • Retinoic Acid acts to neutralize the inhibitory effect of granalocyte-macrophage colony-stimulating factor on allcaline phosphatase activity that is induced by granulocyte colony-stimulating factor. (共著)
    Experimental Hematology 20 482,485 1992
  • Regulation of mRNA levels of alkaline phosphatase gene in neutrophilic granulocytes by granulocyte colony-stimulating factor and retinoic acid. (共著)
    European Journal of Hematology 46 107-111 1991
  • Regulation of alkaline phosphatase activity in neutrophilic granulocytes. (共著)
    Acta Hematologica Japonica 53 1569,1576 1990
  • Changes in hematological and blood chemical findings following saturation diving : analysis of total 113 divers. (共著)
    17th European Undersea Biomedical Society on Diving and Hyperbaric Medicine. Greece. 1991
  • Adeno associated virus 2 co-receptors? (共著)
    Nature Medicine 5(5) 467-468 1999
Display all
Papers(other)close
  • Adeno-associated virus type2 binds to a 150-kilodalton cell membrane glycoprotein.(共著)
    Virology 217(1) 124-130 1996
  • Nucleotide Sequencing and generation of an infectious clone of adeno-associated Virus 3. (共著)
    Virology 221(1) 208-217 1996
  • Leukemia linked to eating disorders. (共著)
    British Medical Journal. 306 830-831 1993
  • Granulocyte colony stimulating factor-producing malignant lymphoma. (共著)
    acta Hematologica 87 156-159 1992
  • Elevated neutrophil function inchronic neutrophilic leukemia. (共著)
    American Journal of Hematology 41 50-56 1992
  • Retinoic Acid acts to neutralize the inhibitory effect of granalocyte-macrophage colony-stimulating factor on allcaline phosphatase activity that is induced by granulocyte colony-stimulating factor. (共著)
    Experimental Hematology 20 482,485 1992
  • Regulation of mRNA levels of alkaline phosphatase gene in neutrophilic granulocytes by granulocyte colony-stimulating factor and retinoic acid. (共著)
    European Journal of Hematology 46 107-111 1991
  • Regulation of alkaline phosphatase activity in neutrophilic granulocytes. (共著)
    Acta Hematologica Japonica 53 1569,1576 1990
  • Changes in hematological and blood chemical findings following saturation diving : analysis of total 113 divers. (共著)
    17th European Undersea Biomedical Society on Diving and Hyperbaric Medicine. Greece. 1991
  • Adeno associated virus 2 co-receptors? (共著)
    Nature Medicine 5(5) 467-468 1999
  • Highly-regulated expression of adeno-associated virus large Rep proteins in stable 293 cell lines using the Cre-lox P switching system
    Journal of General Virology 80 2477-80 1999
  • AAV-3 based vectors transduce hematopoietic cells not susceptible with AAV-2 based vectors
    Journal of General Virology 81 2077-84 2000
  • Triple transduction with Adeno-associated Virus vectors expressing tyrosine hydroxylase. Aromatic-L-amino-acid decarboxylase, and GTP Cyclohydrolase I for Gene therapy of Parlcinson's disease
    Human Gene Therapy 11 1509-19 2000
  • A novel recombinant adeno-associated virus vaccine induces a long-term humoral immune response to human immunodeficiency virus
    Human Gene Therapy 12 1047-61 2001
  • Gamma rays enhance rAAV-mediated transgene expression and cytocidal effect of AAV-HSVtk/gancyclovir on cancer cells
    Cancer Gene Therapy 8 99-106 2001
  • Targeted integration of foreign DNA into a defined locus on Chromosome 19 in K562 cells using AAV-derived components
    International Journal of Hematology 73 469-475 2001
  • Expression of HGF/NK4 in ovarian cancer cells suppresses intraperitoneal dissemination and extends host survival
    Gene Therapy 8, 1450-55 2001
  • Kanazawa T, Mizukami H, Okada T, Hanazono Y, Kume A, Nishino H, Takeuchi K, Kitamura K, Ichimura K, Ozawa K:Suicide Gene Therapy using AAV-HSVtk/ganciclovir in Combination with Irradiation Results in Regeression of Human Head and Neck Cancer Xen・・・
    Gene Tharapy, in press 2002
  • Xin KQ, Ooki T, Jounai N, Kumamoto Y, Mizukami H, Hashimoto K, Hamajima K, Kokima Y, Hirai S, Klinman D, Ozawa K and Okuda K:DNA Vaccine Containing Inverted Terminal Repeats of Adeno-Associtated Virus Enhances Immune Responses against HIV
    J of Gene Med, in press 2002
  • Kobayashi N, Saito T, Uesugi M, Yokoo N, Xin KQ, Mizukami H, Ozawa K and Koshino T:Gene Marking Study of Periosteum-Derived Cells Uing Adeno-associated virus vector
    J of Rheumatology, in press 2002
  • Saga Y, Mizukami H, Suzuki M, Kohno T, Urabe M, Ozawa K, Sato I:Overexpression of PTEN Increases Sensitivity to SN-38, an Active Metabolite of the Topoisomerase I Inhibitor Irinotecan,in Ovarian Cencer Cells
    Clin Cancer Res 8, 1248-52 2002
  • Hasumi Y, Mizukami H, Urabe M, Kohno T, Takeuchi K, Kume A, Momoeda M, Yoshikawa H, Tsuruo T, Shibuya M, Taketani Y, Ozawa K:Soluble Flt-1 expression suppresses carcinomatous ascites in nude mice bearing ovarian cancer Cyotourethrography
    Cancer Res 62, 2019-23 2002
  • Wang L, Muramatsu S, Lu Y, Ikeguchi K, Fujimoto K, Okada T, Mizukami H, Hanazono Y, Kume A, Urano F, Ichinose H, Nagatsu T, Nakano I, and Ozawa K:Delayed delivery of AAV-GDNF prevents nigral neuroreduction and promotes functional recovery in a rat mode・・・
    Gene Ther 9, 381-9 2002
  • Muramatsu S, Fujimoto K, Ikeguchi K, Shizuma N, Kawasaki K, Ono F, Shen Y, Wang L, Mizukami H, Kume A, Matsumura M, Nagatsu I, Urano F, Ichinose H, Nagatsu T, Terao K, Nakano I, Ozawa K:Behavioral recovery in a primate model of Parkinson's disease by t・・・
    Hum Gene There 13, 345-54 2002
  • Shimpo M, Ikeda U, Maeda Y, Takahashi M, Miyashita H, Mizukami H, Urabe M, Kume A, Takizawa T, Shibuya M, Ozawa K, and Shimada K:AAV-mediated VEGF gene transfer into skeletal muscle stimulates angiogenesis and improves blood flow in a rat hindlimb isch・・・
    Cardiovasc Res 53, 993-1001 2002
  • Saga Y, Suzuki M, Mizukami H, Urabe M, Fukushima M, Ozawa K, Sato I:Enhanced expression of thymidylate synthase mediates resistance of uterine cervical cancer cells to radiation
    Oncology 63, 185-91 2002
  • Xin KQ, Ooki T, Mizukami H, Hamajima K, Okudela K, Hashimoto K, Kojima Y, Jounai N, Kumamoto Y, Sasaki S, Klinman D, Ozawa K, Okuda K:Oral administration of recombinant adeno-associated virus elicits human immunodeficiency virus-specific immune responses
    Hum Gene Ther 13,1571-81 2002
  • Wang LJ, Lu YY, Muramatsu S, Ikeguchi K, Fujimoto K, Okada T, Mizukami H, Matsushita T, Hanazono Y, Kume A, Nagatsu T, Ozawa K, Nakano I:Neuroprotective effects of glial cell line-derived neurotrophic factor mediated by an adeno-associated virus vector・・・
    J Neurosci 22, 6920-8 2002
  • Kume A, Koremoto M, Mizukami H, Okada T, Hanazono Y, Sugamura K, Ozawa K:Selective growth advantage of wild-type lymphocytes in X-linked SCID recipients
    Bone Marrow Transplant 30, 113-8 2002
  • Okada T, Shimazaki K, Nomoto T, Mizukami H, Monahan J, Ozawa K, and Kawai N:AAV mediated gene transfer for gene therapy of ischemia-induced neuronal death
    Methods in Enzymology 346, 378-393 2002
  • Mizukami, H., Okada, T., Ogasawara, Y., Matsushita, T., Urabe, M., Kume, A., and Ozawa, K.: Separate control of Rep and Cap expression utilizing mutant and wild-type loxP sequences and improved packaging system for adeno-associated virus vector product・・・
    Mol Biotechnol 27: 7-14 2004
  • Kanazawa, T., Mizukami, H., Okada, T., Hanazono, Y., Kume, A., Nishino, A., Takeuchi, K., Kitamura, K., Ichimura, K., and Ozawa, K.: Suicide gene therapy using AAV-HSVtk/ganciclovir in combination with irradiation results in regression of human head an・・・
    Gene Ther 10: 51-58 2003
  • Iwata, N., Mizukami, H., Shirotani, K., Takaki, Y., Muramatsu, S., Lu, B., Gerard, N.P., Gerard, C., Ozawa, K. and Saido, T.C.: Presynaptic localization of neprilysin contributes to efficient clearance of amyloid-beta peptide in mouse brain.
    J. Neurosci 24: 991-998 2004

Outside Fund Adoption

  • Gene transfer
    :Health and Labour Sciences Research Grants
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Outside Fund Adoptionclose
  • Gene transfer
    :Health and Labour Sciences Research Grants


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