Researchers Database

yonekawa chikara

    EmergencyMedicine Professor
Last Updated :2022/06/02

Researcher Information

J-Global ID

Published Papers

  • Chikara Yonekawa, Masayuki Suzukawa, Keisuke Yamashita, Katsuaki Kubota, Yasuharu Yasuda, Akihiro Kobayashi, Hiroki Matsubara, Yoshiki Toyokuni
    JOURNAL OF TELEMEDICINE AND TELECARE 20 (2) 75 - 81 1357-633X 2014/03 [Refereed][Not invited]
    We constructed a prototype community first responder (CFR) dispatch system. The system sends incident information, including a map, to the chosen CFR's mobile phone. We tested it in a simulation of 30 out-of-hospital cardiac arrest incidents which had occurred in the town of Motegi during the previous year. Thirty off-duty firefighters acted as CFRs and were sent to the same locations. The mean response time (from the CFR receiving dispatch information to arrival at the scene) was 3 min 37s faster than the actual response time in the corresponding historical control, i.e. the response time was reduced by 36% (P< 0.01). The median travel distance of the CFRs was 3.4 km and there was a positive correlation between response time and travel distance. The study showed that interactive communication between dispatcher and CFR was important for effective operation and that CFRs could reach an OHCA patient before the Emergency Medical Service arrives.
  • Yonekawa C, Nakae H, Tajimi K, Asanuma Y
    Therapeutic apheresis and dialysis : official peer-reviewed journal of the International Society for Apheresis, the Japanese Society for Apheresis, the Japanese Society for Dialysis Therapy 1 10 19 - 24 1744-9979 2006/02 [Refereed][Not invited]
  • C Yonekawa, H Nakae, K Tajimi, T Asanuma
    ARTIFICIAL ORGANS 29 (4) 324 - 328 0160-564X 2005/04 [Refereed][Not invited]
    Nine patients with postoperative liver failure were treated with plasma exchange (PE) or PE and continuous hemodiafiltration (CHDF), and various biochemical parameters were determined before and after treatment. Although citrate levels increased significantly after treatment compared with pretreatment levels in both the PE group and the PE + CHDF group (P < 0.0001 and P < 0.0001, respectively), the percentage of the increase in citrate levels was significantly higher in the PE group than in the PE + CHDF group (P=0.0051). Total bilirubin (T-Bil) levels were significantly lower after treatment in both the PE and PE + CHDF groups (P<0.0001 and P=0.0001, respectively). There were no significant differences in T-Bil levels between the two groups (P = 0.5181). There were no significant differences in interleukin (IL)-6 levels before and after treatment in both the PE and PE + CHDF groups (P=0.1281 and P=0.2273, respectively). IL-18 levels were significantly lower after treatment in both the PE and PE+CHDF groups (P<0.0001 and P=0.0002, respectively), but there were no significant differences in the removal rate of IL-18 in both the PE and PE + CHDF groups (P=0.8749). These results indicate that combining PE and CHDF in a series-parallel circuit is an effective modality for suppressing the elevation of blood citrate levels. This finding may have important implications for the development of an effective treatment for patients with postoperative liver failure.
  • Chikara Yonekawa, Hajime Nakae, Ya-Juan Zheng, Hiroshi Wada, Hiroyuki Tanaka, Kimitaka Tajimi
    Research Communications in Molecular Pathology and Pharmacology 115-116 5 - 14 1078-0297 2004 [Refereed][Not invited]
    Interleukin (IL)-15, an inhibitor of tumor necrosis factor (TNF)-α, causes liver injury in mice. We determined levels of IL-15, IL-6, and IL-18 by enzyme-linked immunosorbent assays in 20 patients with acute hepatic failure and examined relationship between these proinflammatory cytokines and IL-15. A significant correlation was observed between the levels of IL-18 and IL-15 (p=0.0118). IL-15 levels in the nonsurvivors were significantly higher than those in the survivors (p=0.0357). Our results suggest that IL-15 overexpression may cause liver injury in human. Copyright © 2004 By PJD Publications Limited.


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