karasawa tadayoshi

FacultyDivisionofInflammationResearch
Job titleResearch AssociateWeb site

Profile

Research Areas

  • Clinical internal medicine / Metabolomics

Research Activities

Papers(paper)

  • Serum Mac-2 Binding Protein Glycosylation isomer predicts the activation of hepatic stellate cells after liver transplantation.
    Yamada N, Katano T, Hirata Y, Okada N, Sanada Y, Ihara Y, Urahashi T, Ushijima K, Karasawa T, Takahashi M, Mizuta K
    Journal of gastroenterology and hepatology Aug. 2018
  • Adeno-associated Virus Vector-mediated Interleukin-10 Induction Prevents Vascular Inflammation in a Murine Model of Kawasaki Disease.
    Nakamura J, Watanabe S, Kimura H, Kobayashi M, Karasawa T, Kamata R, Usui-Kawanishi F, Sadatomo A, Mizukami H, Nagi-Miura N, Ohno N, Kasahara T, Minota S, Takahashi M
    Scientific reports 8(1) 7601 May 2018
  • Saturated Fatty Acids Undergo Intracellular Crystallization and Activate the NLRP3 Inflammasome in Macrophages.
    Karasawa T, Kawashima A, Usui-Kawanishi F, Watanabe S, Kimura H, Kamata R, Shirasuna K, Koyama Y, Sato-Tomita A, Matsuzaka T, Tomoda H, Park SY, Shibayama N, Shimano H, Kasahara T, Takahashi M
    Arteriosclerosis, thrombosis, and vascular biology 38(4) 744-756 Apr. 2018
  • ARIH2 Ubiquitinates NLRP3 and Negatively Regulates NLRP3 Inflammasome Activation in Macrophages.
    Kawashima A, Karasawa T, Tago K, Kimura H, Kamata R, Usui-Kawanishi F, Watanabe S, Ohta S, Funakoshi-Tago M, Yanagisawa K, Kasahara T, Suzuki K, Takahashi M
    Journal of immunology (Baltimore, Md. : 1950) 199(10) 3614-3622 Nov. 2017
  • Interaction of Neutrophils with Macrophages Promotes IL-1β Maturation and Contributes to Hepatic Ischemia-Reperfusion Injury.
    Sadatomo A, Inoue Y, Ito H, Karasawa T, Kimura H, Watanabe S, Mizushina Y, Nakamura J, Kamata R, Kasahara T, Horie H, Sata N, Takahashi M
    Journal of immunology (Baltimore, Md. : 1950) 199(9) 3306-3315 Nov. 2017
  • Role of NLRP3 Inflammasomes in Atherosclerosis.
    Karasawa T, Takahashi M
    Journal of atherosclerosis and thrombosis 24(5) 443-451 May 2017
  • The crystal-induced activation of NLRP3 inflammasomes in atherosclerosis.
    Karasawa T, Takahashi M
    Inflammation and regeneration 37 18 2017
  • The cardiac glycoside ouabain activates NLRP3 inflammasomes and promotes cardiac inflammation and dysfunction.
    Kobayashi M, Usui-Kawanishi F, Karasawa T, Kimura H, Watanabe S, Mise N, Kayama F, Kasahara T, Hasebe N, Takahashi M
    PloS one 12(5) e0176676 2017
  • Caspase-1 deficiency promotes high-fat diet-induced adipose tissue inflammation and the development of obesity.
    Kimura H, Karasawa T, Usui F, Kawashima A, Endo Y, Kobayashi M, Sadatomo A, Nakamura J, Iwasaki Y, Yada T, Tsutsui H, Kasahara T, Takahashi M
    American journal of physiology. Endocrinology and metabolism 311(5) E881-E890 Nov. 2016
  • Palmitic acid induces interleukin-1β secretion via NLRP3 inflammasomes and inflammatory responses through ROS production in human placental cells.
    Shirasuna K, Takano H, Seno K, Ohtsu A, Karasawa T, Takahashi M, Ohkuchi A, Suzuki H, Matsubara S, Iwata H, Kuwayama T
    Journal of reproductive immunology 116 104-112 Aug. 2016
Display all
Papers(paper)close
  • Serum Mac-2 Binding Protein Glycosylation isomer predicts the activation of hepatic stellate cells after liver transplantation.
    Yamada N, Katano T, Hirata Y, Okada N, Sanada Y, Ihara Y, Urahashi T, Ushijima K, Karasawa T, Takahashi M, Mizuta K
    Journal of gastroenterology and hepatology Aug. 2018
  • Adeno-associated Virus Vector-mediated Interleukin-10 Induction Prevents Vascular Inflammation in a Murine Model of Kawasaki Disease.
    Nakamura J, Watanabe S, Kimura H, Kobayashi M, Karasawa T, Kamata R, Usui-Kawanishi F, Sadatomo A, Mizukami H, Nagi-Miura N, Ohno N, Kasahara T, Minota S, Takahashi M
    Scientific reports 8(1) 7601 May 2018
  • Saturated Fatty Acids Undergo Intracellular Crystallization and Activate the NLRP3 Inflammasome in Macrophages.
    Karasawa T, Kawashima A, Usui-Kawanishi F, Watanabe S, Kimura H, Kamata R, Shirasuna K, Koyama Y, Sato-Tomita A, Matsuzaka T, Tomoda H, Park SY, Shibayama N, Shimano H, Kasahara T, Takahashi M
    Arteriosclerosis, thrombosis, and vascular biology 38(4) 744-756 Apr. 2018
  • ARIH2 Ubiquitinates NLRP3 and Negatively Regulates NLRP3 Inflammasome Activation in Macrophages.
    Kawashima A, Karasawa T, Tago K, Kimura H, Kamata R, Usui-Kawanishi F, Watanabe S, Ohta S, Funakoshi-Tago M, Yanagisawa K, Kasahara T, Suzuki K, Takahashi M
    Journal of immunology (Baltimore, Md. : 1950) 199(10) 3614-3622 Nov. 2017
  • Interaction of Neutrophils with Macrophages Promotes IL-1β Maturation and Contributes to Hepatic Ischemia-Reperfusion Injury.
    Sadatomo A, Inoue Y, Ito H, Karasawa T, Kimura H, Watanabe S, Mizushina Y, Nakamura J, Kamata R, Kasahara T, Horie H, Sata N, Takahashi M
    Journal of immunology (Baltimore, Md. : 1950) 199(9) 3306-3315 Nov. 2017
  • Role of NLRP3 Inflammasomes in Atherosclerosis.
    Karasawa T, Takahashi M
    Journal of atherosclerosis and thrombosis 24(5) 443-451 May 2017
  • The crystal-induced activation of NLRP3 inflammasomes in atherosclerosis.
    Karasawa T, Takahashi M
    Inflammation and regeneration 37 18 2017
  • The cardiac glycoside ouabain activates NLRP3 inflammasomes and promotes cardiac inflammation and dysfunction.
    Kobayashi M, Usui-Kawanishi F, Karasawa T, Kimura H, Watanabe S, Mise N, Kayama F, Kasahara T, Hasebe N, Takahashi M
    PloS one 12(5) e0176676 2017
  • Caspase-1 deficiency promotes high-fat diet-induced adipose tissue inflammation and the development of obesity.
    Kimura H, Karasawa T, Usui F, Kawashima A, Endo Y, Kobayashi M, Sadatomo A, Nakamura J, Iwasaki Y, Yada T, Tsutsui H, Kasahara T, Takahashi M
    American journal of physiology. Endocrinology and metabolism 311(5) E881-E890 Nov. 2016
  • Palmitic acid induces interleukin-1β secretion via NLRP3 inflammasomes and inflammatory responses through ROS production in human placental cells.
    Shirasuna K, Takano H, Seno K, Ohtsu A, Karasawa T, Takahashi M, Ohkuchi A, Suzuki H, Matsubara S, Iwata H, Kuwayama T
    Journal of reproductive immunology 116 104-112 Aug. 2016
  • NLRP3 Deficiency Reduces Macrophage Interleukin-10 Production and Enhances the Susceptibility to Doxorubicin-induced Cardiotoxicity.
    Kobayashi M, Usui F, Karasawa T, Kawashima A, Kimura H, Mizushina Y, Shirasuna K, Mizukami H, Kasahara T, Hasebe N, Takahashi M
    Scientific reports 6 26489 May 2016
  • Letter by Karasawa and Takahashi Regarding Article, "Anti-inflammatory and Antiatherogenic Effects of the Inflammasome NLRP3 Inhibitor Arglabin in ApoE2.Ki Mice Fed a High-Fat Diet".
    Karasawa T, Takahashi M
    Circulation 132(21) e249 Nov. 2015
  • NLRP3 Deficiency Improves Angiotensin II-Induced Hypertension But Not Fetal Growth Restriction During Pregnancy.
    Shirasuna K, Karasawa T, Usui F, Kobayashi M, Komada T, Kimura H, Kawashima A, Ohkuchi A, Taniguchi S, Takahashi M
    Endocrinology 156(11) 4281-4292 Nov. 2015
  • Immunoproteasome subunit LMP7 Deficiency Improves Obesity and Metabolic Disorders.
    Kimura H, Usui F, Karasawa T, Kawashima A, Shirasuna K, Inoue Y, Komada T, Kobayashi M, Mizushina Y, Kasahara T, Suzuki K, Iwasaki Y, Yada T, Caturegli P, Takahashi M
    Scientific reports 5 15883 Oct. 2015
  • Role of NLRP3 Inflammasomes for Rhabdomyolysis-induced Acute Kidney Injury.
    Komada T, Usui F, Kawashima A, Kimura H, Karasawa T, Inoue Y, Kobayashi M, Mizushina Y, Kasahara T, Taniguchi S, Muto S, Nagata D, Takahashi M
    Scientific reports 5 10901 Jun. 2015
  • RIP140 as a novel therapeutic target in the treatment of atherosclerosis.
    Karasawa T, Takahashi M
    Journal of molecular and cellular cardiology 81 136-138 Apr. 2015
  • NLRP3 protein deficiency exacerbates hyperoxia-induced lethality through Stat3 protein signaling independent of interleukin-1β.
    Mizushina Y, Shirasuna K, Usui F, Karasawa T, Kawashima A, Kimura H, Kobayashi M, Komada T, Inoue Y, Mato N, Yamasawa H, Latz E, Iwakura Y, Kasahara T, Bando M, Sugiyama Y, Takahashi M
    The Journal of biological chemistry 290(8) 5065-5077 Feb. 2015
  • Inflammasome activation by mitochondrial oxidative stress in macrophages leads to the development of angiotensin II-induced aortic aneurysm.
    Usui F, Shirasuna K, Kimura H, Tatsumi K, Kawashima A, Karasawa T, Yoshimura K, Aoki H, Tsutsui H, Noda T, Sagara J, Taniguchi S, Takahashi M
    Arteriosclerosis, thrombosis, and vascular biology 35(1) 127-136 Jan. 2015
  • Oligomerized CARD16 promotes caspase-1 assembly and IL-1β processing.
    Karasawa T, Kawashima A, Usui F, Kimura H, Shirasuna K, Inoue Y, Komada T, Kobayashi M, Mizushina Y, Sagara J, Takahashi M
    FEBS open bio 5 348-356 2015
  • Hepatic CREB3L3 controls whole-body energy homeostasis and improves obesity and diabetes.
    Nakagawa Y, Satoh A, Yabe S, Furusawa M, Tokushige N, Tezuka H, Mikami M, Iwata W, Shingyouchi A, Matsuzaka T, Kiwata S, Fujimoto Y, Shimizu H, Danno H, Yamamoto T, Ishii K, Karasawa T, Takeuchi Y, Iwasaki H, Shimada M, Kawakami Y, Urayama O, Sone H, Takekoshi K, Kobayashi K, Yatoh S, Takahashi A, Yahagi N, Suzuki H, Yamada N, Shimano H
    Endocrinology 155(12) 4706-4719 Dec. 2014
  • Nanosilica-induced placental inflammation and pregnancy complications: Different roles of the inflammasome components NLRP3 and ASC.
    Shirasuna K, Usui F, Karasawa T, Kimura H, Kawashima A, Mizukami H, Ohkuchi A, Nishimura S, Sagara J, Noda T, Ozawa K, Taniguchi S, Takahashi M
    Nanotoxicology 9(5) 1-14 Sep. 2014
  • ASC in renal collecting duct epithelial cells contributes to inflammation and injury after unilateral ureteral obstruction.
    Komada T, Usui F, Shirasuna K, Kawashima A, Kimura H, Karasawa T, Nishimura S, Sagara J, Noda T, Taniguchi S, Muto S, Nagata D, Kusano E, Takahashi M
    The American journal of pathology 184(5) 1287-1298 May 2014
  • NLRP3 regulates neutrophil functions and contributes to hepatic ischemia-reperfusion injury independently of inflammasomes.
    Inoue Y, Shirasuna K, Kimura H, Usui F, Kawashima A, Karasawa T, Tago K, Dezaki K, Nishimura S, Sagara J, Noda T, Iwakura Y, Tsutsui H, Taniguchi S, Yanagisawa K, Yada T, Yasuda Y, Takahashi M
    Journal of immunology (Baltimore, Md. : 1950) 192(9) 4342-4351 May 2014
  • Interferon-tau attenuates uptake of nanoparticles and secretion of interleukin-1β in macrophages.
    Hara K, Shirasuna K, Usui F, Karasawa T, Mizushina Y, Kimura H, Kawashima A, Ohkuchi A, Matsuyama S, Kimura K, Takahashi M
    PloS one 9(12) e113974 2014
  • Critical role of caspase-1 in vascular inflammation and development of atherosclerosis in Western diet-fed apolipoprotein E-deficient mice.
    Usui F, Shirasuna K, Kimura H, Tatsumi K, Kawashima A, Karasawa T, Hida S, Sagara J, Taniguchi S, Takahashi M
    Biochemical and biophysical research communications 425(2) 162-168 Aug. 2012
  • Inhibition of ubiquitin ligase F-box and WD repeat domain-containing 7α (Fbw7α) causes hepatosteatosis through Krüppel-like factor 5 (KLF5)/peroxisome proliferator-activated receptor γ2 (PPARγ2) pathway but not SREBP-1c protein in mice.
    Kumadaki S, Karasawa T, Matsuzaka T, Ema M, Nakagawa Y, Nakakuki M, Saito R, Yahagi N, Iwasaki H, Sone H, Takekoshi K, Yatoh S, Kobayashi K, Takahashi A, Suzuki H, Takahashi S, Yamada N, Shimano H
    The Journal of biological chemistry 286(47) 40835-40846 Nov. 2011
  • Macrophage Elovl6 deficiency ameliorates foam cell formation and reduces atherosclerosis in low-density lipoprotein receptor-deficient mice.
    Saito R, Matsuzaka T, Karasawa T, Sekiya M, Okada N, Igarashi M, Matsumori R, Ishii K, Nakagawa Y, Iwasaki H, Kobayashi K, Yatoh S, Takahashi A, Sone H, Suzuki H, Yahagi N, Yamada N, Shimano H
    Arteriosclerosis, thrombosis, and vascular biology 31(9) 1973-1979 Sep. 2011
  • Sterol regulatory element-binding protein-1 determines plasma remnant lipoproteins and accelerates atherosclerosis in low-density lipoprotein receptor-deficient mice.
    Karasawa T, Takahashi A, Saito R, Sekiya M, Igarashi M, Iwasaki H, Miyahara S, Koyasu S, Nakagawa Y, Ishii K, Matsuzaka T, Kobayashi K, Yahagi N, Takekoshi K, Sone H, Yatoh S, Suzuki H, Yamada N, Shimano H
    Arteriosclerosis, thrombosis, and vascular biology 31(8) 1788-1795 Aug. 2011
  • Crucial role of a long-chain fatty acid elongase, Elovl6, in obesity-induced insulin resistance.
    Matsuzaka T, Shimano H, Yahagi N, Kato T, Atsumi A, Yamamoto T, Inoue N, Ishikawa M, Okada S, Ishigaki N, Iwasaki H, Iwasaki Y, Karasawa T, Kumadaki S, Matsui T, Sekiya M, Ohashi K, Hasty AH, Nakagawa Y, Takahashi A, Suzuki H, Yatoh S, Sone H, Toyoshima H, Osuga J, Yamada N
    Nature medicine 13(10) 1193-1202 Oct. 2007


Copyright c MEDIA FUSION Co.,Ltd. All rights reserved.