Researchers Database

monden yukifumi

    Pediatrics Associate Professor
Last Updated :2021/11/23

Researcher Information

URL

Research funding number

  • 80382951

J-Global ID

Research Interests

  • PCIT/CARE   AD/HD   Neuroimaging   Neurodevelopmental disorder   光トポグラフィー   

Research Areas

  • Life sciences / Fetal medicine/Pediatrics / Behavioral science
  • Life sciences / Neuroscience - general
  • Life sciences / Neuroscience - general / Neuroimaging

Academic & Professional Experience

  • 2017/04 - Today  Jichi Medical UniversityPediatricsAssociate Professor

Association Memberships

  • 日本薬物脳波学会   日本赤ちゃん学会   日本ADHD学会   日本小児神経学会   日本小児科学会   

Published Papers

  • Saori Fukui, Mitsuru Seki, Takaomi Minami, Kazuhiko Kotani, Kensuke Oka, Akiko Yokomizo, Daisuke Matsubara, Tomoyuki Sato, Yasuyuki Nozaki, Mari Saito, Yutaka Kikuchi, Kenji Miyamoto, Yukifumi Monden, Takanori Yamagata
    Pediatric Rheumatology 19 (1) 2021/12 [Refereed]
     
    Abstract Background High-dose intravenous immunoglobulin (IVIG) is the mainstay of treatment for Kawasaki disease (KD). Usually, 2 g/kg of IVIG is administered over 10–24 h, depending on the institution or physician, but the association between infusion speed and effectiveness has not been reported. In this study, we evaluated the differences in efficacy and safety between two different IVIG administration speeds. Methods This was a multicenter, unblinded, randomized controlled study. Patients newly diagnosed with KD were randomized into two groups: one who received IVIG over 12 h (12H group, double speed), and one that received IVIG over 24 h (24H group, reference speed). The endpoints included the duration of fever, incidence of coronary artery abnormalities (CAAs) and of adverse events. Laboratory data were evaluated before and after IVIG administration. Results A total of 39 patients were enrolled. There was no difference between groups in fever duration after the initiation of IVIG (21 h vs. 21.5 h, p = 0.325), and no patient experienced CAAs. Two adverse events were observed in the 12H group (elevation of aspartate aminotransferase and vomiting), however no severe adverse events requiring treatments or extension of hospital stay were observed in either group. After initial IVIG administration, the change ratio of inflammatory markers, such as white blood cell counts, neutrophils, C-reactive protein, and albumin, did not show significant differences between the two groups. On the other hand, a greater increase of serum immunoglobulin G from its baseline level was observed in the 24H group compared to the 12H group (3037 ± 648 mg/dl vs. 2414 ± 248 mg/dl, p < 0.01). Conclusion The efficacy and safety of IVIG administered over 12 h (double speed) were similar to those administered over 24 h (reference speed). Trial registration University Hospital Medical Information Network (UMIN000014665). Registered 27 July 2014 – Prospectively registered, https://upload.umin.ac.jp/cgi-open-bin/ctr/ctr_view.cgi?recptno=R000017058
  • Developmental > changes to the neural mechanisms underlying level-2 visual perspective- > taking: A functional near-infrared spectroscopy study
    Hirai, M Sakurada, T Ikeda, T Monden, Y Shimoizumi, H Yamagata, T
    Developmental Psychobiology 2021/11 [Refereed][Not invited]
  • Miyuki Matano, Yukifumi Monden, Koyuru Kurane, Masako Kawasaki, Toshiko Kamo
    Pediatrics international : official journal of the Japan Pediatric Society 2021/09
  • Masahiro Hirai, Takeshi Sakurada, Jun Izawa, Takahiro Ikeda, Yukifumi Monden, Hideo Shimoizumi, Takanori Yamagata
    Scientific Reports 11 (1) 2021/08 [Refereed]
     
    AbstractDifficulties with visual perspective-taking among individuals with autism spectrum disorders remain poorly understood. Many studies have presumed that first-person visual input can be mentally transformed to a third-person perspective during visual perspective-taking tasks; however, existing research has not fully revealed the computational strategy used by those with autism spectrum disorders for taking another person’s perspective. In this study, we designed a novel approach to test a strategy using the opposite-directional effect among children with autism spectrum disorders. This effect refers to how a third-person perspective as a visual input alters a cognitive process. We directly manipulated participants’ visual perspective by placing a camera at different positions; participants could watch themselves from a third-person perspective during a reaching task with no endpoint feedback. During a baseline task, endpoint bias (with endpoint feedback but no visual transformation) did not differ significantly between groups. However, the endpoint was affected by extrinsic coordinate information in the control group relative to the autism spectrum disorders group when the visual perspective was transformed. These results indicate an increased reliance on proprioception during the reaching task with perspective manipulation in the autism spectrum disorders group.
  • Takahiro Ikeda, Akari Inoue, Daisuke Tanaka, Tamao Hashimoto, Stephanie Sutoko, Tatsuya Tokuda, Yasushi Kyutoku, Atsushi Maki, Takanori Yamagata, Ippeita Dan, Yukifumi Monden
    Frontiers in Neuroergonomics 2 2021/07 [Refereed][Not invited]
     
    Objective: In the current study, we explored the neural substrate for acute effects of guanfacine extended release (GXR) on inhibitory control in school-aged children with attention deficit hyperactivity disorder (ADHD), using functional near-infrared spectroscopy (fNIRS). Methods: Following a GXR washout period, 12 AD HD children (6–10 years old) performed a go/no-go task before and 3 h after GXR or placebo administration, in a randomized, double-blind, placebo-controlled, crossover design study. In the primary analysis, fNIRS was used to monitor the right prefrontal cortical hemodynamics of the participants, where our former studies showed consistent dysfunction and osmotic release oral system-methylphenidate (OROS-MPH) and atomoxetine hydrochloride (ATX) elicited recovery. We examined the inter-medication contrast, comparing the effect of GXR against the placebo. In the exploratory analysis, we explored neural responses in regions other than the right prefrontal cortex (PFC). Results: In the primary analysis, we observed no significant main effects or interactions of medication type and age in month (two-way mixed ANCOVA, Fs &lt; 0.20, all ps &gt; .05). However, in the post-hoc analysis, we observed significant change in the oxy-Hb signal in the right angular gyrus (AG) for inter-medication (one sample t-test, p &lt; 0.05, uncorrected, Cohen's d = 0.71). Conclusions: These results are different from the neuropharmacological effects of OROS-MPH and ATX, which, in an upregulated manner, reduced right PFC function in ADHD children during inhibitory tasks. This analysis, while limited by its secondary nature, suggested that the improved cognitive performance was associated with activation in the right AG, which might serve as a biological marker to monitor the effect of GXR in the ADHD children.
  • Fumie Ito, Miyuki Matano, Ikuko Kato, Yukifumi Monden, Yuki Sunohara, Masako Kawasaki, Hitoe Kimura, Shima Furuichi, Regina Bussing, Yuka Oe, Nobuaki Morita, Yoshiharu Kim, Elizabeth Brestan‐Knight, Sheila Eyberg, Toshiko Kamo
    Pediatrics International 2021/07 [Refereed]
  • Toshiko Kamo, Fumie Ito, Yukifumi Monden, Regina Bussing, Madoka Niwa, Masako Kawasaki, Miyuki Matano, Yuri Ujiie, Yuko Higaki, Yuka Oe, Nobuaki Morita, Yoshiharu Kim, Elizabeth Brestan Knight, Sheila Eyberg
    Japanese Psychological Research 0021-5368 2021/06 [Refereed]
  • Pulmonary abscess in an infant treated with ultrasound-guided drainage.
    Saitoa T, Matano M, Kodachi T, Fukui K, Monden Y, Fuchimoto Y
    Journal of Pediatric Surgery Case Reports 60 2020/06 [Refereed][Not invited]
  • Koyuru Kurane, Yukifumi Monden, Daisuke Tanaka, Yuji Gunji, Takahiro Ikeda, Akihiko Miyauchi, Hitoshi Osaka, Toshiyuki Takahashi, Takanori Yamagata
    Multiple Sclerosis and Related Disorders 102320 - 102320 2211-0348 2020/06 [Refereed][Not invited]
  • Megumi Kobayashi, Takahiro Ikeda, Tatsuya Tokuda, Yukifumi Monden, Masako Nagashima, Sakae G Mizushima, Takeshi Inoue, Keiichi Shimamura, Yuta Ujiie, Akari Arakawa, Chie Kuroiwa, Mayuko Ishijima, Yuki Kishimoto, So Kanazawa, Takanori Yamagata, Masami K Yamaguchi, Ryoichi Sakuta, Ippeita Dan
    Neurophotonics 7 (2) 025003 - 025003 2020/04 [Refereed][Not invited]
     
    Significance: It has been reported that children with attention-deficit hyperactivity disorder (ADHD) have impairment in the recognition of angry but not of happy facial expressions, and they show atypical cortical activation patterns in response to facial expressions. However, little is known about neural mechanisms underlying the impaired recognition of facial expressions in school-aged children with ADHD and the effects of acute medication on their processing of facial expressions. Aim: We aimed to investigate the possibility that acute administration of methylphenidate (MPH) affects processing of facial expressions in ADHD children. Approach: We measured the hemodynamic changes in the bilateral temporo-occipital areas of ADHD children observing the happy and angry facial expressions before and 1.5 h after MPH or placebo administration in a randomized, double-blind, placebo-controlled, crossover design study. Results: We found that, regardless of medication, happy expressions induced increased oxyhemoglobin (oxy-Hb) responses in the right inferior occipital region but not in the superior temporal region. For angry expressions, oxy-Hb responses increased after MPH administration, but not after placebo administration, in the left inferior occipital area, whereas there was no significant activation before MPH administration. Conclusions: Our results suggest that (1) ADHD children consistently recruit the right inferior occipital regions to process happy expressions and (2) MPH administration to ADHD children enhances cortical activation in the left inferior occipital regions when they process angry expressions.
  • Yuta Kawahara, Akira Morimoto, Yukiko Oh, Rieko Furukawa, Kei Wakabayashi, Yukifumi Monden, Hitoshi Osaka, Takanori Yamagata
    Brain & development 42 (2) 185 - 191 0387-7604 2020/02 [Refereed][Not invited]
     
    BACKGROUND: The pathogenesis of acute encephalopathy (AE) remains unclear, and a biomarker has not been identified. METHODS: Levels of 49 cytokines and chemokines, including osteopontin (OPN), were measured in serum and cerebrospinal fluid (CSF) of children with AE (n = 17) or febrile convulsion (FC; n = 8; control group). The AE group included acute necrotizing encephalopathy (n = 1), acute encephalopathy with biphasic seizures and late reduced diffusion (AESD; n = 3), clinically mild encephalitis/encephalopathy with a reversible splenial lesion (MERS; n = 4), and unclassified acute encephalopathy (UCAE; n = 9) that does not meet the criteria of syndrome classification. Five individuals with AE had neurological sequelae or death (poor prognosis), whereas 12 were alive without neurological sequelae (good prognosis). RESULTS: The CSF:serum ratios of OPN, CC chemokine ligand (CCL)4, and interleukin (IL)-10 were significantly higher in AE than in FC. The CSF levels of macrophage inhibitory factor (MIF) and leukemia inhibitory factor (LIF) were significantly higher in the poor-prognosis group than in the good-prognosis group. The CSF:serum ratios of OPN were significantly higher in AESD and in MERS than in FC. The CSF:serum ratios of MIF and OPN were higher in MERS than in UCAE or FC. CONCLUSION: Our results suggest that microglia-related cytokines and chemokines such as OPN, MIF, and LIF could be novel biomarkers of AE, in addition to the previously reported IL-10 and CCL4, and that MIF and LIF may be markers of poor prognosis.
  • Mary Hanley, Deborah M Riby, Michael-John Derges, Anna Douligeri, Zackary Philyaw, Takahiro Ikeda, Yukifumi Monden, Hideo Shimoizumi, Takanori Yamagata, Masahiro Hirai
    Developmental science e12942  2020/01 [Refereed][Not invited]
     
    Autism spectrum disorders (ASD) are associated with face perception atypicalities, and atypical experience with faces has been proposed as an underlying explanation. Studying the own-race advantage (ORA) for face recognition can reveal the effect of experience on face perception in ASD, although the small number of studies in the area present mixed findings. This study probed the ORA in ASD by comparing two cultural groups simultaneously for the first time. Children with ASD in the UK (N = 16) and Japan (N = 26) were compared with age- and ability-matched typically developing (TD) children in the UK (N = 16) and Japan (N = 26). Participants completed a two-alternative forced-choice task, whereby they had to recognize a just seen face from a foil which was manipulated in one of four ways (IC: identity change; EE: easy eyes; HE: hard eyes; HM: hard mouth). Face stimuli were Asian and Caucasian, and thus the same stimuli were own and other race depending on the cultural group. The ASD groups in the UK and Japan did not show impaired face recognition abilities, or impairments with recognizing faces depending on manipulations to the eye region, and importantly they showed an ORA. There was considerable heterogeneity in the presence of the ORA in ASD and TD and also across cultures. Children in Japan had higher accuracy than children in the UK, and TD children in Japan did not show an ORA. This cross-cultural study challenges the view that atypical experiences with faces lead to a reduced/absent ORA in ASD.
  • Stephanie Sutoko, Yukifumi Monden, Tatsuya Tokuda, Takahiro Ikeda, Masako Nagashima, Tsukasa Funane, Hirokazu Atsumori, Masashi Kiguchi, Atsushi Maki, Takanori Yamagata, Ippeita Dan
    Frontiers in human neuroscience 14 3 - 3 2020 [Refereed][Not invited]
     
    Connectivity between brain regions has been redefined beyond a stationary state. Even when a person is in a resting state, brain connectivity dynamically shifts. However, shifted brain connectivity under externally evoked stimulus is still little understood. The current study, therefore, focuses on task-based dynamic functional-connectivity (FC) analysis of brain signals measured by functional near-infrared spectroscopy (fNIRS). We hypothesize that a stimulus may influence not only brain connectivity but also the occurrence probabilities of task-related and task-irrelevant connectivity states. fNIRS measurement (of the prefrontal-to-inferior parietal lobes) was conducted on 21 typically developing (TD) and 21 age-matched attention-deficit/hyperactivity disorder (ADHD) children performing an inhibitory control task, namely, the Go/No-Go (GNG) task. It has been reported that ADHD children lack inhibitory control; differences between TD and ADHD children in terms of task-based dynamic FC were also evaluated. Four connectivity states were found to occur during the temporal task course. Two dominant connectivity states (states 1 and 2) are characterized by strong connectivities within the frontoparietal network (occurrence probabilities of 40%-56% and 26%-29%), and presumptively interpreted as task-related states. A connectivity state (state 3) shows strong connectivities in the bilateral medial frontal-to-parietal cortices (occurrence probability of 7-15%). The strong connectivities were found at the overlapped regions related the default mode network (DMN). Another connectivity state (state 4) visualizes strong connectivities in all measured regions (occurrence probability of 10%-16%). A global effect coming from cerebral vascular may highly influence this connectivity state. During the GNG stimulus interval, the ADHD children tended to show decreased occurrence probability of the dominant connectivity state and increased occurrence probability of other connectivity states (states 3 and 4). Bringing a new perspective to explain neuropathophysiology, these findings suggest atypical dynamic network recruitment to accommodate task demands in ADHD children.
  • Stephanie Sutoko, Yukifumi Monden, Tatsuya Tokuda, Takahiro Ikeda, Masako Nagashima, Tsukasa Funane, Hiroki Sato, Masashi Kiguchi, Atsushi Maki, Takanori Yamagata, Ippeita Dan
    Neurophotonics 6 (4) 045013 - 045013 2019/10 [Refereed][Not invited]
     
    Connectivity impairment has frequently been associated with the pathophysiology of attention-deficit/hyperactivity disorder (ADHD). Although the connectivity of the resting state has mainly been studied, we expect the transition between baseline and task may also be impaired in ADHD children. Twenty-three typically developing (i.e., control) and 36 disordered (ADHD and autism-comorbid ADHD) children were subjected to connectivity analysis. Specifically, they performed an attention task, visual oddball, while their brains were measured by functional near-infrared spectroscopy. The results of the measurements revealed three key findings. First, the control group maintained attentive connectivity, even in the baseline interval. Meanwhile, the disordered group showed enhanced bilateral intra- and interhemispheric connectivities while performing the task. However, right intrahemispheric connectivity was found to be weaker than those for the control group. Second, connectivity and activation characteristics might not be positively correlated with each other. In our previous results, disordered children lacked activation in the right middle frontal gyrus. However, within region connectivity of the right middle frontal gyrus was relatively strong in the baseline interval and significantly increased in the task interval. Third, the connectivity-based biomarker performed better than the activation-based biomarker in terms of screening. Activation and connectivity features were independently optimized and cross validated to obtain the best performing threshold-based classifier. The effectiveness of connectivity features, which brought significantly higher training accuracy than the optimum activation features, was confirmed (88% versus 76%). The optimum screening features were characterized by two trends: (1) strong connectivities of right frontal, left frontal, and left parietal lobes and (2) weak connectivities of left frontal, left parietal, and right parietal lobes in the control group. We conclude that the attentive task-based connectivity effectively shows the difference between control and disordered children and may represent pathological characteristics to be feasibly implemented as a supporting tool for clinical screening.
  • Stephanie Sutoko, Yukifumi Monden, Tatsuya Tokuda, Takahiro Ikeda, Masako Nagashima, Masashi Kiguchi, Atsushi Maki, Takanori Yamagata, Ippeita Dan
    Frontiers in human neuroscience 13 7 - 7 2019 [Refereed][Not invited]
     
    Attention deficit/hyperactivity disorder (ADHD) has been frequently reported as co-occurring with autism spectrum disorder (ASD). However, ASD-comorbid ADHD is difficult to diagnose since clinically significant symptoms are similar in both disorders. Therefore, we propose a classification method of differentially recognizing the ASD-comorbid condition in ADHD children. The classification method was investigated based on functional brain imaging measured by near-infrared spectroscopy (NIRS) during a go/no-go task. Optimization and cross-validation of the classification method was carried out in medicated-naïve and methylphenidate (MPH) administered ADHD and ASD-comorbid ADHD children (randomized, double-blind, placebo-controlled, and crossover design) to select robust parameters and cut-off thresholds. The parameters could be defined as either single or averaged multi-channel task-evoked activations under an administration condition (i.e., pre-medication, post-MPH, and post-placebo). The ADHD children were distinguished by significantly high MPH-evoked activation in the right hemisphere near the midline vertex. The ASD-comorbid ADHD children tended to have low activation responses in all regions. High specificity (86 ± 4.1%; mean ± SD), sensitivity (93 ± 7.3%), and accuracy (82 ± 1.6%) were obtained using the activation of oxygenated-hemoglobin concentration change in right middle frontal, angular, and precentral gyri under MPH medication. Therefore, the significantly differing MPH-evoked responses are potentially effective features and as supporting differential diagnostic tools.
  • Ikeda Takahiro, Tokuda Tatsuya, Monden Yukifumi, Hirai Masahiro, Mizushima Sakae G, Nagashima Masako, Kyutoku Yasushi, Taniguchi Takamichi, Shimoizumi Hideo, Dan Ippeita, Yamagata Takanori
    JAPANESE PSYCHOLOGICAL RESEARCH 60 (4) 251 - 264 0021-5368 2018/10 [Refereed][Not invited]
     
    Autism spectrum disorder (ASD) and attention-deficit hyperactivity disorder (ADHD) are believed to share the symptom of neurocognitive dysfunction in executive functions. Regarding the components of executive functions, however, dysfunction of motor-response inhibitory control in children with ASD remains unclear. Thus, using functional near-infrared spectroscopy (fNIRS), we investigated whether putative inhibitory brain dysfunctions are applicable to children with ASD by adopting a go/no-go task, which has robustly evoked activation in typically developing (TD) children but not in ADHD children. Twenty-four ASD and 24 TD children underwent a go/no-go task, and their cortical hemodynamics were assessed using fNIRS. Relative to TD participants, ASD participants showed reduced activation in the right inferior frontal gyrus and middle frontal gyrus (IFG/MFG) during go/no-go tasks. The current finding suggests that hypoactivation in the right IFG/MFG during a go/no-go task would serve as a potential biomarker for identifying children with ASD.
  • Stephanie Sutoko, Yukifumi Monden, Tsukasa Funane, Tatsuya Tokuda, Takusige Katura, Hiroki Sato, Masako Nagashima, Masashi Kiguchi, Atsushi Maki, Takanori Yamagata, Ippeita Dan
    Neurophotonics 5 (4) 045001 - 045001 2329-423X 2018/10 [Refereed][Not invited]
     
    Functional near-infrared spectroscopy (fNIRS) signals are prone to problems caused by motion artifacts and physiological noises. These noises unfortunately reduce the fNIRS sensitivity in detecting the evoked brain activation while increasing the risk of statistical error. In fNIRS measurements, the repetitive resting-stimulus cycle (so-called block-design analysis) is commonly adapted to increase the sample number. However, these blocks are often affected by noises. Therefore, we developed an adaptive algorithm to identify, reject, and select the noise-free and/or least noisy blocks in accordance with the preset acceptance rate. The main features of this algorithm are personalized evaluation for individual data and controlled rejection to maintain the sample number. Three typical noise criteria (sudden amplitude change, shifted baseline, and minimum intertrial correlation) were adopted. Depending on the quality of the dataset used, the algorithm may require some or all noise criteria with distinct parameters. Aiming for real applications in a pediatric study, we applied this algorithm to fNIRS datasets obtained from attention deficit/hyperactivity disorder (ADHD) children as had been studied previously. These datasets were divided for training and validation purposes. A validation process was done to examine the feasibility of the algorithm regardless of the types of datasets, including those obtained under sample population (ADHD or typical developing children), intervention (nonmedication and drug/placebo administration), and measurement (task paradigm) conditions. The algorithm was optimized so as to enhance reproducibility of previous inferences. The optimum algorithm design involved all criteria ordered sequentially (0.047 mM mm of amplitude change, 0.029    mM    mm / s of baseline slope, and 0.6 × interquartile range of outlier threshold for each criterion, respectively) and presented complete reproducibility in both training and validation datasets. Compared to the visual-based rejection as done in the previous studies, the algorithm achieved 71.8% rejection accuracy. This suggests that the algorithm has robustness and potential to substitute for visual artifact-detection.
  • Ayumi Matsumoto, Janyerkye Tulyeu, Rieko Furukawa, Chika Watanabe, Yukifumi Monden, Yasuyuki Nozaki, Masato Mori, Michito Namekawa, Eriko F Jimbo, Toshinori Aihara, Takanori Yamagata, Hitoshi Osaka
    Brain & development 40 (7) 587 - 591 0387-7604 2018/08 [Refereed][Not invited]
     
    Alexander disease (AxD) is a progressive neurodegenerative disease caused by a mutation in the glial fibrillary acid protein (GFAP) gene. A 4-year-old boy presented several times with hemiclonic seizures with eye deviation for a few minutes at 28 days after birth. Electroencephalogram showed independent sharp waves in the right and left temporal area. Magnetic resonance imaging showed high intensity T1-weighted images in the white matter of the frontal lobe and basal ganglia. He showed no head control at 4 years of age, and his weight gain was insufficient. He did not show macrocephaly. At 4 years of age, he died of bacterial pneumonia and septic shock. He was diagnosed with AxD, and direct sequencing revealed a de novo known mutation, c. 239 T > C, p.(F80S), in GFAP. Hela and U2-OS cells transfected with GFAP cDNA with c. 239 T > C showed dot-like cytoplasmic aggregation, similar to R239C, a common mutation found in severe infantile AxD. Aggregation in the cytoplasm caused by a GFAP mutation is a hallmark of AxD. Although there is only one previous report of a patient with an F80S mutation, our data support that F80S can cause the severe, infantile form of AxD.
  • Masako Nagashima, Hitoshi Osaka, Takahiro Ikeda, Ayumi Matsumoto, Akihiko Miyauchi, Kimihiko Kaneko, Ichiro Nakashima, Yuko Nakano, Kei Wakabayashi, Yukifumi Monden, Takanori Yamagata
    Brain & development 40 (7) 607 - 611 0387-7604 2018/08 [Refereed][Not invited]
     
    BACKGROUND: The effect of rituximab on acute disseminated encephalomyelitis (ADEM) followed by recurrent optic neuritis (ON) is not yet known. PATIENT: We are reporting the case of a 4-year-old Japanese girl who was diagnosed with anti-myelin oligodendrocyte glycoprotein (MOG) antibody positive ADEM followed by recurrent ON. She developed altered mental status, left facial paralysis, left paresis, and experienced three episodes of ON. She was treated with rituximab and azathioprine (AZA) as prevention for recurrent ON. She relapsed under treatment with AZA when CD19 cells reappeared 6 months after the first rituximab infusion. However, she has not relapsed since her CD19 count was reduced and kept low with rituximab infusion. CONCLUSIONS: It is conceivable that anti-MOG antibodies are involved in the pathology of "ADEM followed by recurrent ON," and that the early introduction of rituximab, which is involved in the suppression of antibody production and has effects on CD20 T lymphocytes, may be a feasible treatment for ON. Due to the small number of patients, additional reports on prospectively followed patients are needed.
  • Takahiro Ikeda, Masahiro Hirai, Takeshi Sakurada, Yukifumi Monden, Tatsuya Tokuda, Masako Nagashima, Hideo Shimoizumi, Ippeita Dan, Takanori Yamagata
    Neurophotonics 5 (3) 035008 - 035008 2329-423X 2018/07 [Refereed][Not invited]
     
    Autism spectrum disorder (ASD) is characterized by impairment in social communication and the presence of restricted and repetitive behaviors and interests. Executive function impairment is reportedly partially responsible for these symptoms. Executive function includes planning, flexibility, and inhibitory control. Although planning and flexibility in ASD have been consistently reported as atypical, the atypicality of inhibitory control remains controversial. As most previous studies have used nonsocial stimuli to investigate inhibitory control in ASD, the effects of socially relevant information on the inhibitory control system in individuals with ASD remain unclear. Therefore, we developed a go/no-go task with gaze stimuli and measured hemodynamic responses in the right prefrontal cortex (PFC), involved in inhibitory processing in both typically developing (TD) children and children with ASD, using functional near-infrared spectroscopy. Direct gaze induced commission errors to similar extents in both groups. Contrary to the behavioral responses, neural activation in the right PFC was modulated by gaze direction only in the TD group. These findings suggest that the gaze-processing mechanisms in the prefrontal region may be affected by atypical gaze processing in other brain regions during an inhibitory control task with socially relevant information in ASD.
  • Akihiko Miyauchi, Hitoshi Osaka, Masako Nagashima, Mari Kuwajima, Yukifumi Monden, Masakazu Kohda, Yoshihito Kishita, Yasushi Okazaki, Kei Murayama, Akira Ohtake, Takanori Yamagata
    Brain & development 40 (6) 498 - 502 0387-7604 2018/06 [Refereed][Not invited]
     
    Leigh syndrome, which is a common phenotype of pediatric mitochondrial disease, is a progressive neurodegenerative disease. The typical neuroimaging findings of Leigh syndrome include bilateral symmetric lesions in the basal ganglia and/or the brainstem. However, there are a few reports on spinal cord involvement in patients with Leigh syndrome. In the present case, magnetic resonance imaging (MRI) obtained during infancy revealed symmetric lesions in the substantia nigra of a patient with Leigh syndrome with an NDUFA1 mutation; lesions of the bilateral putamen and brainstem were subsequently observed. Additionally, our patient presented large and extended spinal cord lesions. Therefore, this case is suggesting that we should consider the occurrence of spinal cord lesions as an atypical finding in Leigh syndrome.
  • Tokuda, T, Ikeda, T, Monden, Y, Mizushima, S. G, Inoue, T, Nagashima, M, Shimamura, K, Arakawa, A, Kobayashi, M, Kuroiwa, C, Ujiie, Y, Dan, H, Kyutoku, Y, Taniguchi, T, Shimoizumi, H, Yamagata, T, Yamaguchi, M. K, Kanazawa, S, Sakuta, R, Dan, I
    Neuropsychiatry 8 (2) 739 - 744 2018/04 [Refereed][Not invited]
  • Tadayuki Ayabe, Kiwako Yamamoto-Hanada, Hidetoshi Mezawa, Mizuho Konishi, Kazue Ishitsuka, Mayako Saito, Maki Fukami, Takehiro Michikawa, Shin Yamazaki, Ayako Senju, Koichi Kusuhara, Toshihiro Kawamoto, Masafumi Sanefuji, Kiyoko Kato, Masako Oda, Hiroshi Mitsubuchi, Takahiko Katoh, Yukifumi Monden, Nathan Mise, Fujio Kayama, Hirohisa Saito, Yukihiro Ohya
    Pediatrics international : official journal of the Japan Pediatric Society 60 (1) 30 - 34 1328-8067 2018/01 [Refereed][Not invited]
     
    BACKGROUND: In recent years, a resurgence in the number of infants with vitamin D deficiency has been noted. In addition to seasonal differences in exposure to ultraviolet (UV) rays, regional differences in dietary habits and lifestyles may affect susceptibility to vitamin D deficiency. No studies have been conducted, however, on infants in multiple regions of Japan to determine the extent of differences in vitamin D status. METHODS: 25-Hydroxyvitamin D (25OHD) was measured on radioimmunoassay in 126 infants aged 2-4 years, who participated in the Pilot Study of the Japan Environment and Children's Study (JECS) by the Ministry of Environment of Japan. A multiple regression model with 25OHD level as the outcome variable, and season and region as explanatory variables, was generated. RESULTS: Both region and season during which infants participated in this study significantly affected 25OHD level (P = 0.0087 and <0.0001, respectively; Wald test). Reflecting decreased exposure to UV rays, infants who were examined in winter had lower 25OHD than those examined in summer. Infants from both Fukuoka Prefecture (33°N) and Kumamoto Prefecture (32°N), however, had lower 25OHD than those from Tochigi Prefecture (36°N), contrary to expectations given the extent of UV exposure. CONCLUSIONS: Regional differences in daily habits and/or environmental factors affect 25OHD level in Japanese infants. The JECS is expected to identify those factors to provide guidance on preventing infantile vitamin D deficiency.
  • Ayabe Tadayuki, Fukami Maki, Yamamoto-Hanada Kiwako, Ishitsuka Kazue, Mezawa Hidetoshi, Konishi Mizuho, Saito Mayako, Sasaki Hatoko, Satoh Miori, Nishizato Minaho, Michikawa Takehiro, Yamazaki Shin, Monden Yukifumi, Mise Nathan, Kayama Fujio, Shimono Masayuki, Kusuhara Koichi, Kawamoto Toshihiro, Sanefuji Masafumi, Kato Kiyoko, Oda Masako, Mitsubuchi Hiroshi, Katoh Takahiko, Saito Hirohisa, Ohya Yukihiro
    HORMONE RESEARCH IN PAEDIATRICS 90 640  1663-2818 2018 [Refereed][Not invited]
  • Ryou Kawamata, Yuji Gunji, Ayafumi Ozaki, Kei Wakabayashi, Yuka Miyajimaa, Yukifumi Monden, Kei Numazaki, Kazuo Takahashi
    Fetal and pediatric pathology 36 (5) 347 - 356 1551-3815 2017/10 [Refereed][Not invited]
     
    INTRODUCTION: Relationships between adipokines, adiposity and severity of acute viral bronchiolitis in infancy have not been elucidated. MATERIALS AND METHODS: We investigated the relationships between three serum adipokines (leptin, adiponectin and TNF-α), physique index (Kaup index) and clinical severity in 13 bronchiolitis infants. Seven healthy infants were enrolled as the control group. We used Modified Pulmonary Index Score (MPIS) to evaluate bronchiolitis severity. RESULTS: No significant differences in adipokine levels were found between groups. In bronchiolitis infants, Kaup index negatively correlated with MPIS (r = -0.614, p = 0.03). A positive correlation was observed between the serum leptin/adiponectin ratio and MPIS (r = 0.618, p = 0.03), although correlations were not observed between respective serum adipokines levels and MPIS. Serum leptin and adiponectin had significantly negative correlations with age (r = 0.815, p = 0.001 and r = 0.566, p = 0.04, respectively), but not Kaup index. CONCLUSION: The severity of viral bronchiolitis in infancy may be related to the adipokine profile, but not adiposity.
  • Saori Sakamoto, Yukifumi Monden, Ryoko Fukai, Noriko Miyake, Hiroshi Saito, Akihiko Miyauchi, Ayumi Matsumoto, Masako Nagashima, Hitoshi Osaka, Naomichi Matsumoto, Takanori Yamagata
    Brain & development 39 (5) 439 - 443 0387-7604 2017/05 [Refereed][Not invited]
     
    We report the case of a 19-year-old female patient who had progressive chorea associated with a GNAO1 mutation. Chorea was refractory to multiple anticonvulsants, and the patient suffered from tiapride-induced neuroleptic malignant syndrome. After identification of a GNAO1 missense mutation at the age of 18years, topiramate treatment was initiated and the frequency of chorea decreased dramatically. The efficacy of topiramate may have been related to the inhibitory modulation of voltage-activated Ca2+ channels. Given the side effects and complications associated with neuroleptics and deep brain stimulation, respectively, topiramate is recommended for the first-line management of severe chorea associated with a GNAO1 mutation.
  • Jun Ito, Takeo Fujiwara, Yukifumi Monden, Takanori Yamagata, Hideki Ohira
    Frontiers in pediatrics 5 271 - 271 2017 [Refereed][Not invited]
     
    Although previous studies have revealed the role of oxytocin (OT) in parental behavior, the role of OT has not been investigated through the direct assessment of prefrontal brain activation during parenting. By using functional near-infrared spectroscopy, we aimed to show the relationship between parental [maternal (N = 15) and paternal (N = 21)] OT levels and the activation of the prefrontal cortex (PFC), while holding their infants after separation. Baseline OT levels were measured in the subjects' saliva samples before the experiment. Prefrontal brain activation was assessed in participants sitting alone on a chair (i.e., separation from their infant for 120 s) and during the target period (i.e., holding their infant for 45 s), which was done in triplicate. The oxygen hemoglobin (oxy-Hb) dissociation curve significantly increased in 9 out of 22 channels on the PFC when maternal and paternal samples were combined. However, only the fathers showed a correlation between salivary OT and oxy-Hb signal. Furthermore, while holding their infants, high-OT fathers showed left hemispheric dominance compared to low-OT fathers, while high-OT mothers showed right hemispheric dominance compared to low-OT mothers. This study showed that fathers with high-OT levels showed neural activation with left hemispheric dominance, while holding their infants, suggesting that increase of OT level might activate paternal PFC related to parenting behavior, although the same is not true for mothers.
  • Akihiko Miyauchi, Yukifumi Monden, Hitoshi Osaka, Yukitoshi Takahashi, Takanori Yamagata
    Brain & development 38 (4) 427 - 30 0387-7604 2016/04 [Refereed][Not invited]
     
    We are reporting on a case of pediatric anti-NMDAR encephalitis with autonomic instability. The patient showed little response to first-line treatment of steroid and IVIG. We initiated plasma exchange, also a first-line treatment. This worsened his autonomic instability, resulting in hypotensive shock. He responded well to rituximab and cyclophosphamide, second-line therapies. Anti-NMDAR encephalitis is often accompanied by autonomic instability. Our and other reported cases, raise the question of plasma exchange as a first-line therapy for pediatric NMDAR encephalitis, which is frequently accompanied by autonomic instability. Plasma exchange should be performed cautiously in such patients.
  • Hirotomo Saitsu, Ryoko Fukai, Bruria Ben-Zeev, Yasunari Sakai, Masakazu Mimaki, Nobuhiko Okamoto, Yasuhiro Suzuki, Yukifumi Monden, Hiroshi Saito, Barak Tziperman, Michiko Torio, Satoshi Akamine, Nagahisa Takahashi, Hitoshi Osaka, Takanori Yamagata, Kazuyuki Nakamura, Yoshinori Tsurusaki, Mitsuko Nakashima, Noriko Miyake, Masaaki Shiina, Kazuhiro Ogata, Naomichi Matsumoto
    European journal of human genetics : EJHG 24 (1) 129 - 34 1018-4813 2016/01 [Refereed][Not invited]
     
    De novo GNAO1 variants have been found in four patients including three patients with Ohtahara syndrome and one patient with childhood epilepsy. In addition, two patients showed involuntary movements, suggesting that GNAO1 variants can cause various neurological phenotypes. Here we report an additional four patients with de novo missense GNAO1 variants, one of which was identical to that of the previously reported. All the three novel variants were predicted to impair Gαo function by structural evaluation. Two patients showed early-onset epileptic encephalopathy, presenting with migrating or multifocal partial seizures in their clinical course, but the remaining two patients showed no or a few seizures. All the four patients showed severe intellectual disability, motor developmental delay, and involuntary movements. Progressive cerebral atrophy and thin corpus callosum were common features in brain images. Our study demonstrated that GNAO1 variants can cause involuntary movements and severe developmental delay with/without seizures, including various types of early-onset epileptic encephalopathy.
  • Yuko Nakano, Yukifumi Monden, Masashi Mizuguchi, Masako Nagashima, Yasunori Koike, Yuji Gunji, Naoto Takahashi, Hideo Sugie, Mariko Y. Momoi, Takanori Yamagata
    NEUROLOGY ASIA 20 (1) 85 - 89 1823-6138 2015/03 [Refereed][Not invited]
     
    Acute encephalopathy is classified into multiple syndromes, such as acute encephalopathy with biphasic seizures and late reduced diffusion (AESD), clinically mild encephalitis/encephalopathy with a reversible splenial lesion (MERS) and acute necrotizing encephalopathy (ANE), characterized radiologically by lesions in the cerebral subcortical white matter, splenium of the corpus callosum and bilateral thalami, respectively. We described a previously healthy 8-year-old boy who had febrile and biphasic seizures, and encephalopathy. MRI showed abnormal signal intensity in the corpus callosum on day 2 and cerebral subcortical white matter and bilateral thalamic lesions on day 8. This is the first case of acute encephalopathy in which callosal, subcortical and thalamic lesions co-existed. The clinical course of this case was typical for AESD, atypical for MERS, and different from that of ANE.
  • Yukifumi Monden, Ippeita Dan, Masako Nagashima, Haruka Dan, Minako Uga, Takahiro Ikeda, Daisuke Tsuzuki, Yasushi Kyutoku, Yuji Gunji, Daisuke Hirano, Takamichi Taniguchi, Hideo Shimoizumi, Eiju Watanabe, Takanori Yamagata
    NeuroImage. Clinical 9 1 - 12 2015 [Refereed][Not invited]
     
    While a growing body of neurocognitive research has explored the neural substrates associated with attention deficit hyperactive disorder (ADHD), an objective biomarker for diagnosis has not been established. The advent of functional near-infrared spectroscopy (fNIRS), which is a noninvasive and unrestrictive method of functional neuroimaging, raised the possibility of introducing functional neuroimaging diagnosis in young ADHD children. Previously, our fNIRS-based measurements successfully visualized the hypoactivation pattern in the right prefrontal cortex during a go/no-go task in ADHD children compared with typically developing control children at a group level. The current study aimed to explore a method of individual differentiation between ADHD and typically developing control children using multichannel fNIRS, emphasizing how spatial distribution and amplitude of hemodynamic response are associated with inhibition-related right prefrontal dysfunction. Thirty ADHD and thirty typically developing control children underwent a go/no-go task, and their cortical hemodynamics were assessed using fNIRS. We explored specific regions of interest (ROIs) and cut-off amplitudes for cortical activation to distinguish ADHD children from control children. The ROI located on the border of inferior and middle frontal gyri yielded the most accurate discrimination. Furthermore, we adapted well-formed formulae for the constituent channels of the optimized ROI, leading to improved classification accuracy with an area under the curve value of 85% and with 90% sensitivity. Thus, the right prefrontal hypoactivation assessed by fNIRS would serve as a potentially effective biomarker for classifying ADHD children at the individual level.
  • Masako Nagashima, Yukifumi Monden, Ippeita Dan, Haruka Dan, Tsutomu Mizutani, Daisuke Tsuzuki, Yasushi Kyutoku, Yuji Gunji, Daisuke Hirano, Takamichi Taniguchi, Hideo Shimoizumi, Mariko Y Momoi, Takanori Yamagata, Eiju Watanabe
    Neurophotonics 1 (2) 025007 - 025007 2329-423X 2014/10 [Refereed][Not invited]
     
    The current study aimed to explore the neural substrate for atomoxetine effects on attentional control in school-aged children with attention deficit hyperactivity disorder (ADHD) using functional near-infrared spectroscopy (fNIRS), which can be applied to young children with ADHD more easily than conventional neuroimaging modalities. Using fNIRS, we monitored the oxy-hemoglobin signal changes of 15 ADHD children (6 to 14 years old) performing an oddball task before and 1.5 h after atomoxetine or placebo administration, in a randomized, double-blind, placebo-controlled, crossover design. Fifteen age-, gender-, and intelligence quotient-matched normal controls without atomoxetine administration were also monitored. In the control subjects, the oddball task recruited the right prefrontal and inferior parietal cortices. The right prefrontal and parietal activation was normalized after atomoxetine administration in ADHD children. This was in contrast to our previous study using a similar protocol showing methylphenidate-induced normalization of only the right prefrontal function. fNIRS allows the detection of differential neuropharmacological profiles of both substances in the attentional network: the neuropharmacological effects of atomoxetine to upregulate the noradrenergic system reflected in the right prefrontal and inferior parietal activations and those of methylphenidate to upregulate the dopamine system reflected in the prefrontal cortex activation.
  • Masako Nagashima, Yukifumi Monden, Ippeita Dan, Haruka Dan, Daisuke Tsuzuki, Tsutomu Mizutani, Yasushi Kyutoku, Yuji Gunji, Mariko Y Momoi, Eiju Watanabe, Takanori Yamagata
    Neurophotonics 1 (1) 015001 - 015001 2329-423X 2014/07 [Refereed][Not invited]
     
    The current study aimed to explore the neural substrate for methylphenidate effects on attentional control in school-aged children with attention deficit hyperactivity disorder (ADHD) using functional near-infrared spectroscopy (fNIRS), which can be applied to young children with ADHD more easily than conventional neuroimaging modalities. Using fNIRS, we monitored the oxy-hemoglobin signal changes of 22 ADHD children (6 to 14 years old) performing an oddball task before and 1.5 h after methylphenidate or placebo administration, in a randomized, double-blind, placebo-controlled, crossover design. Twenty-two age- and gender-matched normal controls without methylphenidate administration were also monitored. In the control subjects, the oddball task recruited the right prefrontal and inferior parietal cortices, and this activation was absent in premedicated ADHD children. The reduced right prefrontal activation was normalized after methylphenidate but not placebo administration in ADHD children. These results are consistent with the neuropharmacological effects of methylphenidate to upregulate the dopamine system in the prefrontal cortex innervating from the ventral tegmentum (mesocortical pathway), but not the noradrenergic system from the parietal cortex to the locus coeruleus. Thus, right prefrontal activation would serve as an objective neurofunctional biomarker to indicate the effectiveness of methylphenidate on ADHD children in attentional control. fNIRS monitoring enhances early clinical diagnosis and the treatment of ADHD children, especially those with an inattention phenotype.
  • Akihiko Miyauchi, Yukifumi Monden, Meri Watanabe, Hideo Sugie, Mitsuya Morita, Takeshi Kezuka, Mariko Momoi, Takanori Yamagata
    Neuropediatrics 45 (3) 196 - 9 0174-304X 2014/06 [Refereed][Not invited]
     
    We report the case of a 5-year-old Japanese girl who initially had acute disseminated encephalomyelitis (ADEM) and was positive for the myelin oligodendrocyte glycoprotein (MOG) antibodies and developed unilateral optic neuritis (ON) 71 days after ADEM onset. The patient's serum was positive for the anti-MOG antibodies from the onset of ADEM to the development of ON. This phenotype has been reported in only two previous articles, and the specific mechanism of action of the anti-MOG antibodies is not yet understood. Our case suggests that the anti-MOG antibody can be associated with the pathogenesis of ADEM followed by ON. Thus, patients with ADEM who test positive for the anti-MOG antibody may be at risk of developing subsequent ON.
  • Masako Nagashima, Yukifumi Monden, Ippeita Dan, Haruka Dan, Daisuke Tsuzuki, Tsutomu Mizutani, Yasushi Kyutoku, Yuji Gunji, Daisuke Hirano, Takamichi Taniguchi, Hideo Shimoizumi, Mariko Y Momoi, Eiju Watanabe, Takanori Yamagata
    NeuroImage. Clinical 6 192 - 201 2014 [Refereed][Not invited]
     
    The object of the current study is to explore the neural substrate for effects of atomoxetine (ATX) on inhibitory control in school-aged children with attention deficit hyperactivity disorder (ADHD) using functional near-infrared spectroscopy (fNIRS). We monitored the oxy-hemoglobin signal changes of sixteen ADHD children (6-14 years old) performing a go/no-go task before and 1.5 h after ATX or placebo administration, in a randomized, double-blind, placebo-controlled, crossover design. Sixteen age- and gender-matched normal controls without ATX administration were also monitored. In the control subjects, the go/no-go task recruited the right inferior and middle prefrontal gyri (IFG/MFG), and this activation was absent in pre-medicated ADHD children. The reduction of right IFG/MFG activation was acutely normalized after ATX administration but not placebo administration in ADHD children. These results are reminiscent of the neuropharmacological effects of methylphenidate to up-regulate reduced right IFG/MFG function in ADHD children during inhibitory tasks. As with methylphenidate, activation in the IFG/MFG could serve as an objective neuro-functional biomarker to indicate the effects of ATX on inhibitory control in ADHD children. This promising technique will enhance early clinical diagnosis and treatment of ADHD in children, especially in those with a hyperactivity/impulsivity phenotype.
  • Yukifumi Monden, Masato Mori, Mari Kuwajima, Tamako Goto, Takanori Yamagata, Mariko Y Momoi
    Brain & development 35 (6) 582 - 5 0387-7604 2013/06 [Refereed][Not invited]
     
    We report the case of a boy with myoclonic epilepsy with ragged-red fibers (MERRF) who had astatic seizures since 2 years of age and later developed ataxia, absence seizures, and myoclonus. Almost homoplasmic A8344G mutation of mitochondrial DNA (m.8344A>G mutation) was detected in lymphocytes. He developed late-onset Leigh syndrome (LS) when he contracted pneumonia at 6 years. He developed bulbar palsy and deep coma. MRI demonstrated lesions in the brainstem, basal ganglia, and cerebral cortex. Three similar cases have been reported; two carried the almost-homoplasmic m.8344A>G mutation in muscle tissue. These suggested that almost homoplastic m.8344A>G mutation developed clinical phenotype of MERRF in the early stage and late-onset Leigh syndrome in the late course of the disease.
  • Yukifumi Monden, Haruka Dan, Masako Nagashima, Ippeita Dan, Yasushi Kyutoku, Masako Okamoto, Takanori Yamagata, Mariko Y Momoi, Eiju Watanabe
    Clinical neurophysiology : official journal of the International Federation of Clinical Neurophysiology 123 (6) 1147 - 57 1388-2457 2012/06 [Refereed][Not invited]
     
    OBJECTIVE: Attention Deficit Hyperactivity Disorder (ADHD), a common developmental syndrome with inattention, hyperactivity, and impulsivity, is typically treated with the psychostimulant drug, methylphenidate (MPH). We explored the feasibility of using functional near-infrared spectroscopy (fNIRS) to search for a clinically implementable biological marker for the acute MPH effect on ADHD children. METHODS: Following an MPH washout period, twelve ADHD children performed a go/no-go task before and 1.5 h after MPH intake. fNIRS was used to monitor the lateral prefrontal cortical hemodynamics of ADHD children performing a go/no-go task. RESULTS: There was no significant activation in the lateral prefrontal cortices examined before MPH intake. However, after MPH intake, significant MPH-elicited activation (oxygenated hemoglobin signal increase) was detected in the right lateral prefrontal cortex (LPFC) implicated with response inhibition functions. There was a large significant correlation between increases in task performance and activation in the right LPFC. CONCLUSIONS: The improved cognitive performance was associated with activation in the right LPFC, which might serve as a biological marker to monitor the effect of MPH in ADHD children. SIGNIFICANCE: MPH-effect assessment in ADHD children using fNIRS can be performed within a 3 h stay at a hospital during a single visit, and thus may be integrated into clinical practice.
  • Yukifumi Monden, Takanori Yamagata, Yuri Kuroiwa, Toshiyuki Takahashi, Masato Mori, Tokiko Fukuda, Hideo Sugie, Mariko-Yoshida Momoi
    Brain & development 34 (5) 380 - 3 0387-7604 2012/05 [Refereed][Not invited]
     
    The patient was a 14-year-old male diagnosed with acute disseminated encephalomyelitis (ADEM) with acute onset of multifocal central nervous system symptoms. He showed increased cerebrospinal fluid cell counts and high myelin basic protein levels, which responded well to steroid pulse therapy. Spinal MRI showed a centrally-located long spinal cord lesion (LCL) involving 17 vertebral bodies from C2 to T11 that later expanded into the white matter, and lesions on the ventral side of the medulla. The cause of LCL has been reported to be heterogeneous. In this case, LCL is considered to be associated with ADEM, an acute autoimmune response to myelin, and vascular inflammation of the gray matter of the spinal cord.
  • Yukifumi Monden, Haruka Dan, Masako Nagashima, Ippeita Dan, Daisuke Tsuzuki, Yasushi Kyutoku, Yuji Gunji, Takanori Yamagata, Eiju Watanabe, Mariko Y Momoi
    NeuroImage. Clinical 1 (1) 131 - 40 2213-1582 2012 [Refereed][Not invited]
     
    An objective biomarker is a compelling need for the early diagnosis of attention deficit hyperactivity disorder (ADHD), as well as for the monitoring of pharmacological treatment effectiveness. The advent of fNIRS, which is relatively robust to the body movements of ADHD children, raised the possibility of introducing functional neuroimaging diagnosis in younger ADHD children. Using fNIRS, we monitored the oxy-hemoglobin signal changes of 16 ADHD children (6 to 13 years old) performing a go/no-go task before and 1.5 h after MPH or placebo administration, in a randomized, double-blind, placebo-controlled, crossover design. 16 age- and gender-matched normal controls without MPH administration were also monitored. Relative to control subjects, unmedicated ADHD children exhibited reduced activation in the right inferior frontal gyrus (IFG) and middle frontal gyrus (MFG) during go/no-go tasks. The reduced right IFG/MFG activation was acutely normalized after MPH administration, but not after placebo administration. The MPH-induced right IFG/MFG activation was significantly larger than the placebo-induced activation. Post-scan exclusion rate was 0% among 16 right-handed ADHD children with IQ > 70. We revealed that the right IFG/MFG activation could serve as a neuro-functional biomarker for monitoring the acute effects of methylphenidate in ADHD children. fNIRS-based examinations were applicable to ADHD children as young as 6 years old, and thus would contribute to early clinical diagnosis and treatment of ADHD children.
  • Monden Yukifumi, Shiraishi Hirohiko, Ichida Fukiko, Momoi Mariko
    Pediatric cardiology 32 (2) 206 - 7 0172-0643 2011/02 [Refereed][Not invited]

Conference Activities & Talks

  • Potential of practical Internet-delivered Parent-child Interaction Therapy in the COVID-19 era
    倉根超, 俣野美雪, 山形崇倫, 門田行史
    第63回日本小児神経学会学術集会 優秀English session賞  2021/05
  • 光トポグラフィー検査を用いたAD/HDに対するグアンファシン(GXR)の脳機能学的薬理作用の可視化
    池田尚広, 門田行史, 井上あかり, Stephanie Sutoko, 徳田竜也, 橋本珠緒, 田中大輔, 牧敦, 山形崇倫, 檀一平太
    第63回日本小児神経学会学術集会 優秀口演セッション  2021/05
  • 乳幼児期のADHD支援  [Invited]
    門田行史
    日本ADHD学会第12回総会シンポジウム  2021/03
  • Eyberg Child Behavior Inventory (ECBI)を用いた Parent-Child Interaction Therapy (PCIT)の 問題行動に対する有効性の評価 ―自閉スペクトラム症を持つ児を中心に―
    俣野美雪, 門田行史, 川崎雅子, 加茂登志子
    日本ADHD学会第12回総会  2021/03
  • With コロナ時代の挑戦 -親子相互交流療法(PCIT)の実践  [Invited]
    Monden Yukifumi
    日本赤ちゃん学会第20回学術学会  2020/09

MISC

  • 若江 恵三, 門田 行史, 井上 俊, 小太刀 豪, 俣野 美雪, 郡司 勇治, 山形 崇倫  小児科臨床  74-  (3)  277  -281  2021/03  
    急性呼吸不全が原因で入院を繰り返す重症心身障害児に対し、在宅非侵襲的陽圧換気療法(noninvasive positive pressure ventilation;NPPV)を呼吸状態の安定時に使用する効果について検証した。重症心身障害児3例を対象に、在宅NPPV導入前後の入院回数を後方視的に比較した結果、在宅NPPV導入前の5年間で、全症例において呼吸障害を原因とする入院が5〜17回であったが、導入後は入院回数が0回となり、在宅NPPVの高い有効性を示した。また、全症例で在宅NPPV導入前に気管切開術の実施を家族と協議したが、気管切開術の高い侵襲性のため実施に至らなかったが、在宅NPPVは迅速に導入できた。本邦の重症心身障害児に対する在宅NPPV導入は、他の呼吸管理法と比べて途上であり、今後の普及が待たれる。(著者抄録)
  • 育児困難感を抱える養育者に対するParent child interaction therapy(PCIT)の効果
    俣野 美雪, 門田 行史  国際医療福祉大学学会誌  25-  (抄録号)  200  -200  2020/11
  • 小倉 一輝, 若林 慶, 上田 清史, 門田 行史  Journal of Clinical Rehabilitation  29-  (10)  1081  -1084  2020/09  
    症例は9歳男児で、NICU入院時の頭部エコーで左側脳室内出血を認めた。四肢の麻痺と痙縮のため、障害の程度は大島分類で区分1の重症心身障害児でありADLは全介助であった。9歳時にバクロフェン髄注療法(ITB療法)を導入し、導入前には上肢1.58点、下肢3.00点であったAshworth scaleは導入後1週間には上肢1.33点、下肢1.58点と低下した。しかし、下肢では導入後3年時点で1.83点と導入前よりは低下していたものの微増した。ADLの評価を目的とした介護者アンケートでは、ITB療法導入前は11点であったが、導入後2ヵ月で13点、4ヵ月で23点と経時的にADLの改善を認め、3年時点でも25点とADLは維持されていた。J-ZBIを用いた介護者の介護負担感の評価は痙縮の評価と同時に行い、ITB療法導入後4ヵ月までは導入前の41点から変化は認めなかったが、導入後3年時点では16点まで低下した。脳性麻痺による重症心身障害児の介護負担に対しITB療法が有用であった。
  • 井上 俊, 小倉 一輝, 武田 昭, 俣野 美雪, 小太刀 豪, 沼崎 啓, 郡司 勇治, 高橋 和郎, 山岸 佑也, 森本 哲, 山形 崇倫, 門田 行史  小児科臨床  73-  (7)  1027  -1030  2020/07  
    肢端紅痛症は、四肢末端の発赤・疼痛を特徴とする稀な疾患であるが、その臨床的特徴によって診断するため、同症状を訴える患者を見た際には念頭に置くべき病態である。しばしば難治性で、確立した治療法はない。今回、ステロイドによる早期治療が、慢性疼痛への移行を防ぐうえで有効であったと推測される小児例を経験したので報告する。症例は10歳女児。両手指の色調変化と疼痛を訴えて受診した。手指末端の灼熱痛、色調変化、熱感を認めた。疼痛は加温で増悪し、冷却で軽快した。これら臨床的特徴および他疾患の除外により、肢端紅痛症と診断した。続発性の肢端紅痛症を来す基礎疾患の存在は除外され、一次性肢端紅痛症と考えた。鎮痛薬(アセトアミノフェン)で疼痛は抑えられず、ステロイド薬治療を開始して軽減した。さらに、低用量アスピリンを加え、ステロイド薬の減量を進めながら、ガバペンチンの内服を併用し、疼痛は改善した。(著者抄録)
  • 若年発症潰瘍性大腸炎の2症例における治療経験 小児科・小児外科との連携、病病連携を通して
    福井 慶介, 齋藤 傑, 森川 康英, 小倉 一輝, 井上 俊, 小太刀 豪, 俣野 美雪, 門田 行史, 高橋 和郎, 郡司 勇治, 沼崎 啓, 渕本 康史, 横山 孝二, 熊谷 秀規  日本小児科学会雑誌  124-  (5)  876  -876  2020/05
  • 早期のステロイド治療が有効だった肢端紅痛症の1例
    井上 俊, 小倉 一輝, 武田 昭, 俣野 美雪, 小太刀 豪, 沼崎 啓, 郡司 勇治, 高橋 和郎, 森本 哲, 山形 崇倫, 門田 行史  日本小児科学会雑誌  124-  (5)  877  -877  2020/05
  • 門田 行史  Gノート  6-  (8)  1222  -1228  2019/12  [Not refereed][Not invited]
     
    <Point>●ADHDは「本人の努力の問題」「しつけの問題」が原因ではない●ADHDの症状の見分け方のコツは、"頑固な傾向"を探すことである●ADHD治療の目的は、二次障がいを予防・治療することである(著者抄録)
  • 子ども虐待予防のための新しい親子支援「PCITとCARE」を介した取り組み 教育・行政・医療現場での取り組みとこれから PCITとCAREを介した取り組み 医療現場から(2)
    門田 行史  子どもの心とからだ  28-  (3)  321  -321  2019/11  [Not refereed][Not invited]
  • Megumi Kobayashi, Masako Nagashima, Tatsuya Tokuda, Takahiro Ikeda, Yukifumi Monden, So Kanazawa, Masami K. Yamaguchi, Ryoichi Sakuta, Takanori Yamagata, Ippeita Dan  I-PERCEPTION  10-  169  -169  2019/09
  • ADHD児童における表情認知の神経基盤 近赤外分光法による検討
    小林 恵, 池田 尚広, 徳田 竜也, 長嶋 雅子, 門田 行史, 金沢 創, 山口 真美, 作田 亮一, 山形 崇倫, 檀 一平太  日本心理学会大会発表論文集  83回-  481  -481  2019/08  [Not refereed][Not invited]
  • 若林 慶, 水野 晴夫, 田中 大輔, 久保 達也, 高橋 和郎, 山岸 裕和, 渡辺 浩史, 下泉 秀夫, 山形 崇倫, 沼崎 啓, 郡司 勇治, 門田 行史  小児科臨床  72-  (2)  199  -203  2019/02  [Not refereed][Not invited]
     
    症例は生来健康な11歳の女児。小学校2年次(7歳時)から不注意症状による学業成績の低下がみられた。8歳以降に体重増加不良、眼球突出、甲状腺腫大が出現し、11歳時にBasedow病と診断された。Basedow病の治療後に不注意症状が著しく改善した経過から、原因不明の学業成績の低下を初期症状とした低年齢の小児の場合には、学習障害や注意欠如多動症(attention deficit hyperactivity disorder:ADHD)のほかに身体疾患であるBasedow病を鑑別に挙げるべきである。(著者抄録)
  • 宮内 彰彦, 門田 行史  神経眼科  35-  (4)  404  -411  2018/12  [Not refereed][Not invited]
     
    抗myelin oligodendrocyte glycoprotein(MOG)抗体は、近年、中枢神経系脱髄疾患における新たな標的抗原として注目を集めている。抗MOG抗体は、構造的なエピトープを抗体が認識できるように通常cell-based assay(CBA)法で検出される。小児科領域では主に急性散在性脳脊髄炎(acute disseminated encephalomyelitis:ADEM)や抗AQP4抗体陰性の視神経脊髄炎関連疾患(neuromyelitis optica spectrum disorder:NMOSD)、特発性視神経炎(idiopathic optic neuritis:ION)などで関連が報告されている。治療に関しては、急性発作時はステロイド治療や血漿交換療法に良く反応するが、再発性の経過を辿ることも多いため長期的なフォローや予防目的の免疫抑制療法が推奨される。以上から、抗MOG抗体の有無は、小児脱髄疾患の病態分類、および治療選択に関与する重要な指標として注目されている。そこで、本項では、抗MOG抗体の検出方法の推移や関連する小児脱髄疾患、および抗MOG抗体陽性の脱髄疾患の治療や予後について紹介する。(著者抄録)
  • 長嶋 雅子, 池田 尚広, 門田 行史  最新医学  73-  (10)  1362  -1367  2018/10  [Not refereed][Not invited]
     
    神経発達症の1つである注意欠如・多動症(ADHD)は、先天性の脳機能障害が原因と考えられている。ADHDの病態解明や、早期発見・治療効果に関与する客観的バイオマーカーの確立を目的とした生理学的研究は、脳波(EEG)、機能的磁気共鳴画像(fMRI)、陽電子放射断層撮影(SPECT)、脳磁図(MEG)、光トポグラフィー(fNIRS)など、多岐に及ぶ。本稿では、低拘束性や非侵襲性などの特徴を持つ脳機能イメージングであるfNIRSを用いた研究を中心に最近の生物学的知見を紹介する。(著者抄録)
  • 「子どもと親のこころの脳科学研究「発達障がいの子どもと養育者支援〜脳とこころを視て理解する〜」」 ADHDの病態と治療反応性を『視る』fNIRSを用いて
    門田 行史  子どもの心とからだ  27-  (2)  196  -196  2018/08  [Not refereed][Not invited]
  • ADHD診断・治療 脳機能検査を用いたイノベーション研究成果の報告
    門田 行史, 下泉 秀夫, 谷口 敬道  国際医療福祉大学学会誌  23-  (抄録号)  20  -20  2018/08  [Not refereed][Not invited]
  • 栃木県における脳性麻痺児の実態把握に関する疫学調査(多施設共同後向き観察研究)
    山岸 裕和, 下泉 秀夫, 小坂 仁, 今高 城治, 渡部 功之, 門田 行史, 高橋 努, 石井 徹, 影山 さち子, 小黒 範子, 中野 俊至, 椎原 弘章, 山口 康, 小林 靖明, 吉田 真, 野崎 靖之, 菊地 豊, 渡部 あずさ, 佐藤 吉壮, 桑島 信, 近藤 理  日本小児科学会雑誌  122-  (7)  1265  -1265  2018/07  [Not refereed][Not invited]
  • 門田 行史  外来小児科  21-  (2)  196  -196  2018/07  [Not refereed][Not invited]
  • 長嶋 雅子, 池田 尚広, 門田 行史  日本臨床  76-  (4)  622  -625  2018/04  [Not refereed][Not invited]
  • 田中 大輔, 水野 晴夫, 田中 達之, 若林 慶, 久保 達也, 高橋 和郎, 山形 崇倫, 沼崎 啓, 郡司 勇治, 齋藤 伸治, 門田 行史  日本小児科学会雑誌  122-  (4)  839  -839  2018/04  [Not refereed][Not invited]
  • エコチル調査パイロット調査における幼児のビタミンD濃度の地域差の検討
    綾部 匡之, 山本 貴和子, 目澤 秀俊, 石塚 一枝, 齋藤 麻耶子, 深見 真紀, 千手 絢子, 楠原 浩一, 實藤 雅文, 小田 政子, 三渕 浩, 門田 行史, 斎藤 博久, 大矢 幸弘  日本小児科学会雑誌  122-  (2)  368  -368  2018/02  [Not refereed][Not invited]
  • 久保 達也, 若林 慶, 田中 大輔, 水野 晴夫, 沼崎 啓, 郡司 勇治, 門田 行史  日本小児科学会雑誌  121-  (12)  2035  -2035  2017/12  [Not refereed][Not invited]
  • 若林 慶, 水野 晴夫, 田中 大輔, 久保 達也, 高橋 和郎, 山岸 裕和, 渡辺 浩史, 下泉 秀夫, 山形 崇倫, 沼崎 啓, 郡司 勇治, 門田 行史  日本小児科学会雑誌  121-  (12)  2034  -2035  2017/12  [Not refereed][Not invited]
  • 尾崎 理史, 宮内 彰彦, 松本 歩, 門田 行史, 保科 優, 菊池 豊, 古川 理恵子, 小坂 仁, 相原 敏則, 山形 崇倫  日本小児科学会雑誌  121-  (8)  1391  -1396  2017/08  [Refereed][Not invited]
     
    3ヵ月男児。父と入浴中に心肺停止状態となり、救急隊による蘇生後、小児集中治療室へ搬送された。受傷機転不明の急性硬膜下血腫、眼底出血を認めたため虐待関連頭部外傷を疑ったが、入院時の問診では虐待を疑うエピソードを確認できなかった。びまん性脳浮腫を認めたため頸椎MRIを撮影し、Short Tau Inversion Recovery矢状断像にて項靱帯や棘間靱帯などの椎体支持組織および頸髄内部が高信号を示し、頸髄損傷を示唆する所見であった。後日、父が本児を強く揺さぶったことが確認され、乳幼児揺さぶられ症候群による上位頸髄損傷から呼吸停止および心肺停止状態に至ったと判断した。入院経過中、各種治療への反応は乏しく徐々に多臓器不全の状態を呈し、第41病日に死亡した。
  • 若林 慶, 門田 行史, 小坂 仁, 尾崎 理史, 古井 麻衣, 宮島 有果, 川又 竜, 久保 達也, 小池 泰敬, 田中 惠子, 沼崎 啓, 高橋 和郎, 山形 崇倫, 郡司 勇治  日本小児科学会雑誌  121-  (7)  1252  -1252  2017/07  [Not refereed][Not invited]
  • 井澤 淳, 平井 真洋, 櫻田 武, 池田 尚広, 門田 行史, 山形 崇倫, 下泉 秀夫  脳と発達  49-  (Suppl.)  S201  -S201  2017/05  [Not refereed][Not invited]
  • 山岸 裕和, 小坂 仁, 長嶋 雅子, 桑島 真理, 宮内 彰彦, 池田 尚広, 小島 華林, 松本 歩, 門田 行史, 山形 崇倫  脳と発達  49-  (Suppl.)  S376  -S376  2017/05  [Not refereed][Not invited]
  • 小林 瑞, 池田 尚広, 宮内 彰彦, 長嶋 雅子, 門田 行史, 小坂 仁, 山形 崇倫  脳と発達  49-  (Suppl.)  S449  -S449  2017/05  [Not refereed][Not invited]
  • 肺炎球菌ワクチン接種後にワクチン非含有血清型による侵襲性肺炎球菌感染症を発症した1例
    尾崎 理史, 門田 行史, 高橋 和郎, 川又 竜, 若林 慶, 久保 達也, 宮島 有果, 小池 泰敬, 沼崎 啓, 山形 崇倫, 郡司 勇治  日本小児科学会雑誌  121-  (4)  772  -772  2017/04  [Not refereed][Not invited]
  • Stephanie Sutoko, Tsukasa Funane, Takusige Katura, Hiroki Sato, Masashi Kiguchi, Atsushi Maki, Yukifumi Monden, Masako Nagashima, Takanori Yamagata, Ippeita Dan  Progress in Biomedical Optics and Imaging - Proceedings of SPIE  10059-  2017  [Not refereed][Not invited]
     
    In pediatrics studies, the quality of functional near infrared spectroscopy (fNIRS) signals is often reduced by motion artifacts. These artifacts likely mislead brain functionality analysis, causing false discoveries. While noise correction methods and their performance have been investigated, these methods require several parameter assumptions that apparently result in noise overfitting. In contrast, the rejection of noisy signals serves as a preferable method because it maintains the originality of the signal waveform. Here, we describe a semi-learning algorithm to detect and eliminate noisy signals. The algorithm dynamically adjusts noise detection according to the predetermined noise criteria, which are spikes, unusual activation values (averaged amplitude signals within the brain activation period), and high activation variances (among trials). Criteria were sequentially organized in the algorithm and orderly assessed signals based on each criterion. By initially setting an acceptable rejection rate, particular criteria causing excessive data rejections are neglected, whereas others with tolerable rejections practically eliminate noises. fNIRS data measured during the attention response paradigm (oddball task) in children with attention deficit/hyperactivity disorder (ADHD) were utilized to evaluate and optimize the algorithm's performance. This algorithm successfully substituted the visual noise identification done in the previous studies and consistently found significantly lower activation of the right prefrontal and parietal cortices in ADHD patients than in typical developing children. Thus, we conclude that the semi-learning algorithm confers more objective and standardized judgment for noise rejection and presents a promising alternative to visual noise rejection.
  • 自閉症スペクトラム児における視点変換時の運動プランニング方略
    平井真洋, 櫻田武, 井澤淳, 池田尚広, 門田行史, 下泉秀夫, 山形崇倫  発達神経科学学会 第5回大会  2016/11  [Not refereed][Not invited]
  • 定型発達とAD/HDの年齢に依存する脳機能変化の可視化 光トポグラフィーを用いて
    門田 行史  日本小児精神神経学会プログラム・抄録集  116回-  29  -29  2016/11  [Not refereed][Not invited]
  • 門田 行史  臨床神経生理学  44-  (5)  384  -384  2016/10  [Not refereed][Not invited]
  • 当院で2015年に経験した新生児呼吸障害75例の検討
    久保 達也, 若林 慶, 尾崎 理文, 川又 竜, 門田 行史, 宮島 有果, 沼崎 啓, 郡司 勇治  日本小児科学会雑誌  120-  (10)  1558  -1559  2016/10  [Not refereed][Not invited]
  • スチリペントールが著効したPCDH19関連てんかんの1例
    山岸 裕和, 小坂 仁, 日暮 憲道, 池田 尚広, 宮内 彰彦, 長嶋 雅子, 門田 行史, 桑島 真理, 廣瀬 伸一, 山形 崇倫  てんかん研究  34-  (2)  533  -533  2016/09  [Not refereed][Not invited]
  • 乳幼児の急性細気管支炎とアディポカインの関係の解析
    川又 竜, 郡司 勇治, 門田 行史, 尾崎 理史, 若林 慶, 宮島 有果, 久保 達也, 小池 泰敬, 高橋 和郎, 沼崎 啓  国際医療福祉大学学会誌  21-  (抄録号)  57  -57  2016/08  [Not refereed][Not invited]
  • 脳機能バイオマーカーを用いたADHD診断、薬効評価プログラムの社会実装
    池田 尚広, 門田 行史  栃木県医学会々誌  46-  82  -83  2016/06  [Not refereed][Not invited]
  • 尾崎 理史, 宮内 彰彦, 松本 歩, 門田 行史, 小坂 仁, 保科 優, 古川 理恵子, 相原 敏則, 山形 崇倫  脳と発達  47-  (5)  375  -375  2015/09  [Not refereed][Not invited]
  • NIRS計測を用いた小児ADHD治療薬の効果判定法の開発
    門田 行史, 山形 崇倫  メディックス  63-  8  -12  2015/09  [Not refereed][Not invited]
  • 難治性てんかんと退行を示したMECP2重複症候群兄弟例の発作型と脳波の経年的変化
    若林 慶, 長嶋 雅子, 宮内 彰彦, 小島 華林, 後藤 昌英, 安済 達也, 植田 綾子, 門田 行史, 小高 淳, 横山 孝二, 小坂 仁, 山形 崇倫  てんかん研究  33-  (2)  599  -599  2015/09  [Not refereed][Not invited]
  • 田中 大輔, 門田 行史, 石井 朋之, 宮内 彰彦, 山形 崇倫  小児科臨床  68-  (7)  1361  -1365  2015/07  [Not refereed][Not invited]
     
    片側顔面神経麻痺が先行し、両側顔面神経麻痺、さらに両側上下肢の感覚優位の末梢神経障害が出現した小児例を経験した。初発症状が片側顔面神経麻痺であり、Bell麻痺と診断され、近医でステロイド内服治療が開始された。5日後に感覚優位の両側末梢神経障害が出現し、髄液検査では細胞数6mm3、蛋白67mg/dLと蛋白細胞解離を認めた。Guillain-Barre症候群と診断しγグロブリン治療を実施した。約30日で右顔面神経麻痺は消失したが、左顔面神経麻痺は消失までに約400日を要した。通常、Guillain-Barre症候群の末梢神経障害は、下肢から上行性に障害が及ぶが、スペクトラムとして本症例のように顔面神経麻痺が先行する例がある。抗ガングリオシド抗体が陰性であり、ほかの自己抗体産生が誘因となりGuillain-Barre症候群様の病態を呈したと推測した。(著者抄録)
  • 桑島 真理, 長嶋 雅子, 中野 祐子, 門田 行史, 小坂 仁, 山形 崇倫  脳と発達  47-  (Suppl.)  S230  -S230  2015/05  [Not refereed][Not invited]
  • 坂本 沙織, 門田 行史, 深井 綾子, 三宅 紀子, 齊藤 洋, 小坂 仁, 長嶋 雅子, 松本 直通, 山形 崇倫  脳と発達  47-  (Suppl.)  S282  -S282  2015/05  [Not refereed][Not invited]
  • 中野 祐子, 池田 尚広, 宮内 彰彦, 長嶋 雅子, 門田 行史, 桑島 真理, 小坂 仁, 山形 崇倫  脳と発達  47-  (Suppl.)  S289  -S289  2015/05  [Not refereed][Not invited]
  • 宮内 彰彦, 宮武 聡子, 輿水 江里子, 小島 華林, 門田 行史, 西野 一三, 松本 直通, 小坂 仁, 山形 崇倫  脳と発達  47-  (Suppl.)  S403  -S403  2015/05  [Not refereed][Not invited]
  • 宮内 彰彦, 門田 行史, 長嶋 雅子, 杉江 秀夫, 小黒 範子, 小坂 仁, 山形 崇倫  脳と発達  47-  (1)  62  -62  2015/01  [Not refereed][Not invited]
  • 才津浩智, 深井綾子, 酒井康成, 三牧正和, 三牧正和, 岡本伸彦, 鈴木保宏, 門田行史, 齊藤洋, 鳥尾倫子, 赤峰哲, 高橋長久, 小坂仁, 山形崇倫, 中村和幸, 中島光子, 鶴崎美徳, 三宅紀子, 椎名政昭, 緒方一博, 松本直通  日本人類遺伝学会大会プログラム・抄録集  60th-  296  2015  [Not refereed][Not invited]
  • SUTOKO Stephanie, FUNANE Tsukasa, FUNANE Tsukasa, KATURA Takusige, SATO Hiroki, MAKI Atsushi, MONDEN Yukifumi, NAGASHIMA Masako, UGA Minako, UGA Minako, DAN Ippeita, DAN Ippeita, YAMAGATA Takanori  レーザー学会研究会報告  484th-  23  -28  2015  [Not refereed][Not invited]
  • 池田 尚広, 山崎 雅世, 鈴木 峻, 門田 行史, 小坂 仁, 杉江 秀夫, 新保 裕子, 山形 崇倫  脳と発達  46-  (6)  454  -454  2014/11  [Not refereed][Not invited]
  • 臍帯血移植後に混合キメラを呈した副腎白質ジストロフィーの1例
    宮内 彰彦, 門田 行史, 池田 尚広, 川原 勇太, 長嶋 雅子, 杉江 秀夫, 小坂 仁, 森本 哲, 下澤 伸行, 山形 崇倫  日本先天代謝異常学会雑誌  30-  127  -127  2014/10  [Not refereed][Not invited]
  • 長嶋 雅子, 森 雅人, 門田 行史, 福田 冬季子, 野崎 靖之, 杉江 秀夫, 山形 崇倫, 桃井 真里子  小児科臨床  67-  (9)  1549  -1555  2014/09  [Not refereed][Not invited]
     
    目的:小児の在宅人工呼吸器管理(HMV)の背景と問題点を明らかにすることを目的とした。対象と方法:当院のHMV児(者)37例を対象に、HMVの現状を介護者への調査票により評価した(回収率68%)。結果:基礎疾患は、中枢神経疾患68%、神経筋疾患24%だった。89%が重症心身障害児(者)であり、数種類の専門的な医療的ケアや手技を必要としていた。在宅移行例は年々増加し、特に6歳未満で増加していた。HMVの利点として、家族が一緒にいられる(100%)、児の成長が得られる(79%)、介護者が納得するケアができる(74%)などが挙げられた。一方、療育費の自己負担が大きい(79%)、レスパイト施設利用が不便(68%)などの困難さが挙げられた。考察:HMVは、家族にとって利点が多い反面、金銭的、人的負担が大きいと考えられた。今後、レスパイト施設の拡充、療育費の補助拡大を検討する必要があると考えられた。(著者抄録)
  • 急性散在性脳脊髄炎治癒後に視神経炎を発症した3例
    宮内 彰彦, 中野 祐子, 長嶋 雅子, 門田 行史, 渡辺 芽里, 谷河 純平, 杉江 秀夫, 小坂 仁, 佐久間 啓, 山形 崇倫  神経免疫学  19-  (1)  94  -94  2014/09  [Not refereed][Not invited]
  • 小児ADHDの注意機能に関する脳機能障害部位と塩酸メチルフェニデートの効果 fNIRSを用いた検討
    長嶋 雅子, 門田 行史, 檀 一平太, 檀 はるか, 水谷 勉, 郡司 勇治, 桃井 真里子, 渡辺 英寿, 山形 崇倫  日本薬物脳波学会雑誌  15-  (1)  33  -45  2014/08  [Not refereed][Not invited]
     
    小児注意欠陥多動障害(ADHD)の注意機能障害に関与する脳機能低下部位を明確にする事を目的に、注意機能課題(Oddball課題)遂行時にfNIRS計測を実施した。また、注意機能障害に対する塩酸メチルフェニデート徐放剤(MPH)の作用を脳機能学的に検討するためにプラセボ二重盲検試験を行った。IQが70以上の右利きのADHD(年齢6-14歳)児22人を対象とし、Oddball課題施行中にfNIRS計測を実施し、脳機能変化を酸素化ヘモグロビン(oxy-Hb)濃度の変化を用いて評価した。ADHD群と年齢、性別を統計学的に合致させた6-13歳の対照群22人の検討も行った。対照群において右前頭前野と右下頭頂葉に有意な活性を認めたが、MPH内服前とプラセボ内服後のADHD群では活性がなかった。一方、MPH内服後のADHD群において、右前頭前野にのみ活性を認めた。右前頭前野の脳機能変化は、ドパミントランスポーターに親和性が高いMPHが、ドパミン系回路であるmesocortical pathwayに作用したと考えられた。さらに、fNIRSにより認めた小児ADHDの右前頭前野機能不全は、ADHDの病態特性を示すバイオマーカーとなり、治療薬であるMPHの薬理効果の指標となりうると考えられた。(著者抄録)
  • 急性散在性脳脊髄炎治癒後に視神経炎を発症した3例
    宮内 彰彦, 中野 祐子, 長嶋 雅子, 門田 行史, 渡辺 芽里, 谷河 純平, 杉江 秀夫, 小坂 仁, 佐久間 啓, 山形 崇倫  NEUROINFECTION  19-  (2)  172  -172  2014/08  [Not refereed][Not invited]
  • Akihiko Miyauchi, Yukifumi Monden, Meri Watanabe, Hideo Sugie, Mitsuya Morita, Takeshi Kezuka, Mariko Momoi, Takanori Yamagata  NEUROPEDIATRICS  45-  (3)  E2  -E2  2014/06  [Not refereed][Not invited]
  • 臍帯血造血幹細胞移植を実施した1歳10ヵ月の副腎白質ジストロフィー例
    尾崎 理史, 宮内 彰彦, 門田 行史, 新島 瞳, 八木 正樹, 川原 勇太, 小坂 仁, 杉江 秀夫, 森本 哲, 下澤 伸行, 山形 崇倫  日本小児科学会雑誌  118-  (6)  993  -994  2014/06  [Not refereed][Not invited]
  • 門田 行史, 檀 一平太, 山形 崇倫  脳と発達  46-  (Suppl.)  S208  -S208  2014/05  [Not refereed][Not invited]
  • 谷口 祐子, 池田 尚広, 宮内 彰彦, 石井 朋之, 長嶋 雅子, 門田 行史, 小坂 仁, 杉江 秀夫, 高橋 幸利, 山形 崇倫  脳と発達  46-  (Suppl.)  S269  -S269  2014/05  [Not refereed][Not invited]
  • 池田 尚広, 山形 崇倫, 谷口 祐子, 宮内 彰彦, 石井 朋之, 長嶋 雅子, 門田 行史, 小坂 仁, 杉江 秀夫  脳と発達  46-  (Suppl.)  S304  -S304  2014/05  [Not refereed][Not invited]
  • 宮内 彰彦, 門田 行史, 池田 尚広, 川原 勇太, 長嶋 雅子, 小坂 仁, 杉江 秀夫, 森本 哲, 渡辺 浩史, 下泉 秀夫, 下澤 伸行, 山形 崇倫  脳と発達  46-  (Suppl.)  S325  -S325  2014/05  [Not refereed][Not invited]
  • 門田 行史, 山形 崇倫  小児科診療  77-  (増刊)  856  -858  2014/04  [Not refereed][Not invited]
     
    社会性の障害、コミュニケーション障害、常同的行動を特徴とする発達障害の一つである。脳機能の発達に関係する障害を原因として、症状が幼児期早期に出現し生涯続く。環境調整、構造化、行動療法的対応、意思伝達手段を作り、パニックなどに対し薬物療法を検討する。(著者抄録)
  • 植田 綾子, 池田 尚広, 英 雅世, 門田 行史, 森本 哲, 杉江 秀夫, 五味 玲, 古川 理恵子, 相原 敏則, 山形 崇倫  脳と発達  46-  (1)  59  -60  2014/01  [Not refereed][Not invited]
  • 非ヘルペス性急性辺縁系脳炎後に脱力発作を来した1例
    池田 尚広, 門田 行史, 英 雅世, 宮内 彰彦, 石井 朋之, 森 雅人, 杉江 秀夫, 高橋 幸利, 山形 崇倫  てんかん研究  31-  (3)  543  -543  2014/01  [Not refereed][Not invited]
  • 島村 若通, 西村 仁, 門田 行史, 横山 孝二, 熊谷 秀規, 桃井 真里子  日本小児栄養消化器肝臓学会雑誌  27-  (2)  171  -171  2013/11  [Not refereed][Not invited]
  • 宮内 彰彦, 山形 崇倫, 渡辺 芽里, 英 雅代, 伊東 岳峰, 門田 行史, 森 雅人, 杉江 秀夫, 桃井 真里子  脳と発達  45-  (5)  397  -397  2013/09  [Not refereed][Not invited]
  • トピラマートの難治性てんかん小児例に対する治療効果の検討
    宮内 彰彦, 池田 尚広, 長嶋 雅子, 門田 行史, 森 雅人, 杉江 秀夫, 山形 崇倫  てんかん研究  31-  (2)  445  -445  2013/09  [Not refereed][Not invited]
  • 小児の在宅人工呼吸器管理の現状と問題点
    長嶋 雅子, 森 雅人, 門田 行史, 福田 冬季子, 野崎 靖之, 杉江 秀夫, 山形 崇倫  日本重症心身障害学会誌  38-  (2)  252  -252  2013/08  [Not refereed][Not invited]
  • 勝部 奈都子, 長嶋 雅子, 門田 行史, 福田 冬季子, 野崎 靖之, 森 雅人, 杉江 秀夫, 山形 崇倫, 桃井 真里子  日本小児科学会雑誌  117-  (6)  1008  -1013  2013/06  [Refereed][Not invited]
     
    2000〜2010年の10年間に当科で入院加療したインフルエンザ菌髄膜炎22例について、臨床経過と治療効果を後方視的に検討した。BLPAR 2例とBLNAR 8例を耐性菌群、BLNAS 12例を非耐性菌群とした。その結果、耐性菌群では経過良好群が6例(60%)、難治群は4例(40%)であった。非耐性菌群では経過良好群が7例(58%)、難治群が5例(42%)であった。非耐性菌群では月齢が低いほど難治で、1歳未満は全例難治であった。診断時髄液糖値は、耐性菌難治群で血糖値の16%以下で、経過良好群より低値を示した。治療開始7日以内にCTXまたはMEPM単剤治療した14例中6例(42.9%)で後遺症を残し、2剤併用継続例の後遺症は8例中1例(12.5%)であった。合併症に関しては、難聴例で発症時髄液細胞数が有意に多く、知的障害例で月齢が有意に低かった。初期治療への反応性と後遺症との相関性はみられなかった。耐性菌難治群の硬膜下膿瘍1例でCPが著効した。
  • Facial Diplegia with Paresthesiaの4歳女児例
    田中 大輔, 石井 朋之, 勝部 奈都子, 宮内 彰彦, 門田 行史, 横山 孝二, 森 雅人, 山形 崇倫, 桃井 真里子  日本小児科学会雑誌  117-  (5)  924  -925  2013/05  [Not refereed][Not invited]
  • 血球貪食症候群を合併したデング熱の1例 本年の流行を踏まえて
    鈴木 悠, 門田 行史, 横山 孝二, 法月 正太郎, 谷口 祐子, 島村 若通, 池田 尚広, 川原 勇太, 森本 哲, 森澤 雄司, 桃井 真里子  日本小児科学会雑誌  117-  (5)  926  -926  2013/05  [Not refereed][Not invited]
  • 7価肺炎球菌結合型ワクチンに含まれない血清型に起因した肺炎球菌性髄膜炎の1例
    島村 若通, 門田 行史, 横山 孝二, 勝部 奈都子, 木村 岳人, 俣野 美雪, 池田 貴江, 五十嵐 浩, 桃井 眞里子  日本小児科学会雑誌  117-  (5)  930  -930  2013/05  [Not refereed][Not invited]
  • 宮内 彰彦, 山形 崇倫, 中山 佐与, 門田 行史, 森 雅人, 福田 冬季子, 杉江 秀夫, 高橋 幸利, 桃井 眞里子  脳と発達  45-  (Suppl.)  S292  -S292  2013/05  [Not refereed][Not invited]
  • 谷口 祐子, 山形 崇倫, 池田 尚広, 宮内 彰彦, 門田 行史, 森 雅人, 野崎 靖之, 杉江 秀夫, 高橋 幸利, 桃井 眞里子  脳と発達  45-  (Suppl.)  S318  -S318  2013/05  [Not refereed][Not invited]
  • 石井 朋之, 山形 崇倫, 宮内 彰彦, 池田 尚広, 門田 行史, 森 雅人, 桃井 眞里子  脳と発達  45-  (Suppl.)  S389  -S389  2013/05  [Not refereed][Not invited]
  • 池田 尚広, 門田 行史, 宮内 彰彦, 森 雅人, 山形 崇倫, 杉江 秀夫, 桃井 眞里子  脳と発達  45-  (Suppl.)  S410  -S410  2013/05  [Not refereed][Not invited]
  • 英 雅世, 山形 崇倫, 池田 尚広, 宮内 彰彦, 石井 朋之, 長嶋 雅子, 門田 行史, 森 雅人, 杉江 秀夫, 桃井 眞里子  脳と発達  45-  (Suppl.)  S412  -S412  2013/05  [Not refereed][Not invited]
  • 谷口 祐子, 門田 行史, 英 雅世, 醍醐 政樹, 嶋岡 鋼, 梅崎 光, 田中 吾朗, 沼崎 啓, 福田 冬季子, 山形 崇倫, 天野 直子, 長谷川 奉延, 桃井 真里子, 郡司 勇治  小児科臨床  66-  (2)  247  -252  2013/02  [Not refereed][Not invited]
     
    新生児期に急性副腎不全を呈したX連鎖性先天性副腎低形成症の男児例を報告する。出生直後から全身に色素沈着があり、日齢7に急性腎盂腎炎を契機に副腎不全が増悪し、副腎皮質ステロイド投与により軽快した。新生児期の急性副腎不全は死亡率が高いため、色素沈着を呈する新生児で、マススクリーニング(17α-OHP)陰性の場合、本疾患を疑い、早期に副腎機能のスクリーニングを行う必要がある。(著者抄録)
  • 長嶋 雅子, 森 雅人, 門田 行史, 山形 崇倫, 野崎 靖之, 福田 冬季子, 杉江 秀夫, 桃井 真里子  脳と発達  45-  (1)  62  -63  2013/01  [Not refereed][Not invited]
  • 門田 行史, 山形 崇倫  小児科  53-  (11)  1457  -1463  2012/10  [Not refereed][Not invited]
  • 長嶋 雅子, 門田 行史, 檀 はるか, 檀 一平太, 續木 大介, 久徳 康史, 山形 崇倫, 郡司 勇治, 渡辺 英寿, 桃井 真里子  臨床神経生理学  40-  (5)  425  -425  2012/10  [Not refereed][Not invited]
  • Hunter症候群における酵素補充療法の経過
    長嶋 雅子, 山形 崇倫, 池田 尚弘, 宮内 彰彦, 南 孝臣, 門田 行史, 桃井 真理子  日本先天代謝異常学会雑誌  28-  139  -139  2012/10  [Not refereed][Not invited]
  • 宮内 彰彦, 山形 崇倫, 門田 行史, 福田 冬季子, 長嶋 雅子, 杉江 秀夫, 桃井 真里子  小児科臨床  65-  (7)  1693  -1698  2012/07  [Not refereed][Not invited]
     
    2000年4月から2011年4月までの11年間に経験したGBS髄膜炎7例を後方視的に検討した。髄液蛋白高値、髄液糖低値、人工呼吸や昇圧剤投与を要する例、急性期の難治性けいれんの合併が神経学的予後関連因子であると考えられた。検討症例の中で、児の髄膜炎症状が母体の乳腺炎症状に先行した。母乳感染による遅発性GBS髄膜炎の1症例を経験した。遅発型GBS感染症では母乳感染が感染経路の一つであり、GBS感染症と診断された場合は、母体の症状の有無にかかわらず、母乳の培養検査を行い、陽性例では母乳の中止、母体への抗生物質の投与を検討すべきである。(著者抄録)
  • 難治てんかん患者におけるレベチラセタムの有効性
    松本 瞳, 山形 崇倫, 長嶋 雅子, 門田 行史, 野崎 靖之, 福田 冬季子, 森 雅人, 杉江 秀夫, 桃井 真里子  脳と発達  44-  (Suppl.)  S222  -S222  2012/05  [Not refereed][Not invited]
  • 多彩な画像所見を示したけいれん重積型脳症の1例
    谷口 祐子, 山形 崇倫, 門田 行史, 長嶋 雅子, 池田 尚広, 森 雅人, 英 雅世, 福田 冬季子, 郡司 勇治, 杉江 秀夫, 桃井 真里子  脳と発達  44-  (Suppl.)  S228  -S228  2012/05  [Not refereed][Not invited]
  • 小児の在宅人工呼吸器管理児の現状と問題点
    長嶋 雅子, 森 雅人, 門田 行史, 福田 冬季子, 野崎 靖之, 山形 崇倫, 杉江 秀夫, 桃井 真里子  脳と発達  44-  (Suppl.)  S363  -S363  2012/05  [Not refereed][Not invited]
  • ショックを呈した発作性上室性頻拍でカテーテルアブレーションが奏功した新生児の1例
    鈴木 峻, 和田 聖哉, 佐藤 智幸, 門田 行史, 高田 亜希子, 片岡 功一, 南 孝臣, 金井 孝裕, 福田 冬季子, 白石 裕比湖, 桃井 真里子, 籏 義人, 五十嵐 浩  日本小児科学会雑誌  116-  (4)  768  -768  2012/04  [Not refereed][Not invited]
  • 家族歴から早期治療が可能だったX連鎖性先天性副腎低形成の1新生児例
    谷口 祐子, 門田 行史, 英 雅世, 醍醐 政樹, 嶋岡 鋼, 梅崎 光, 沼崎 啓, 田中 吾朗, 福田 冬季子, 山形 崇倫, 桃井 真里子, 郡司 勇治  日本小児科学会雑誌  116-  (4)  767  -767  2012/04  [Not refereed][Not invited]
  • 門田 行史, 山形 崇倫, 森 雅人, 村山 圭, 大竹 明, 桃井 真里子  脳と発達  44-  (2)  155  -155  2012/03  [Not refereed][Not invited]
  • 井上 元子, 山形 崇倫, 門田 行史, 英 雅世, 森 雅人, 福田 冬季子, 野崎 靖之, 長嶋 雅子, 水口 雅, 杉江 秀夫, 桃井 眞里子  小児科臨床  64-  (10)  2215  -2223  2011/10  [Not refereed][Not invited]
     
    2006年〜2010年の4年間に経験した急性脳症の40例を、後方視的に検討した。症例数は40例で、年齢は8ヵ月〜14歳10ヵ月であった。疾患の内訳は出血性ショック脳症(HSES)1例、急性脳浮腫型(ABS)2例、けいれん重積型脳症(AESD)13例、可逆性の脳梁膨大部病変を有する脳炎脳症4例、けいれん後意識障害遷延例11例、意識障害/異常行動遷延例9例だった。原因と思われる疾患背景は突発性発疹12例、インフルエンザ13例、胃腸炎2例、テオフィリン1例であった。7例で大量メチルプレドニゾロン療法等を実施した。予後は2例が死亡、13例に後遺症があり、25例は後遺症なしであった。HSES、ABSは、積極的に治療しても、病勢の進行が速い例での治療は困難であった。初回けいれんの時間が長い、初回けいれん後の意識回復が悪い、脳波で異常所見がある、二峰目のけいれん時間が長い、等の例で後遺症を残す傾向があるが、短時間のけいれんでも後遺症がある例があり、早期診断、治療法確立が重要である。(著者抄録)
  • 門田 行史, 中瀬 葉子, 中村 幸恵, 早瀬 朋美, 翁 由紀子, 柏井 良文, 郡司 勇治, 今村 俊彦, 森本 哲, 桃井 真里子  小児科臨床  64-  (9)  2047  -2051  2011/09  [Not refereed][Not invited]
     
    急性リンパ性白血病/非ホジキンリンパ腫の初発症状の5%に眼球突出があり、視力の保持の観点からは重要な所見である。今回我々は視力について異なる転帰をとった2例を経験した。症例1は2歳の男児。主訴は右眼球突出。眼症状以外の所見なく、CTで眼窩内腫瘤があり、発症1ヵ月時に摘出術を実施し、病理像はsmall round cell tumorであった。骨髄穿刺で芽球を67%認め、B前駆型急性リンパ性白血病(ALL)と診断し、発症後8週目から化学療法を開始した。眼窩の残存腫瘤は速やかに消失し寛解したが、右側の視力は光覚弁であった。症例2は6ヵ月の女児。主訴は左眼球突出。MRIで眼窩内腫瘤を認めた。胸水貯留があり、胸腔穿刺でB前駆型非ホジキンリンパ腫と診断し、発症3週間目にALLに準じた化学療法を開始した。速やかに眼窩腫瘤は消失、寛解し、視力は保たれた。眼窩腫瘤の原因鑑別診断には急性白血病/非ホジキンリンパ腫を鑑別する必要がある。(著者抄録)
  • 難治てんかん患者におけるレベチラセタムの使用経験
    松本 瞳, 山形 崇倫, 森 雅人, 福田 冬季子, 野崎 靖之, 杉江 秀夫, 門田 行史, 長嶋 雅子, 桃井 真里子  てんかん研究  29-  (2)  303  -303  2011/09  [Not refereed][Not invited]
  • 黒岩 祐梨, 門田 行史, 岡野 彩子, 福田 冬季子, 森 雅人, 山形 崇倫, 杉江 秀夫, 桃井 真里子  脳と発達  43-  (3)  251  -251  2011/05  [Not refereed][Not invited]
  • 英 雅世, 山形 崇倫, 井上 元子, 門田 行史, 後藤 珠子, 桃井 真理子  脳と発達  43-  (Suppl.)  S218  -S218  2011/05  [Not refereed][Not invited]
  • 長嶋 雅子, 森 雅人, 門田 行史, 山形 崇倫, 桃井 真里子  脳と発達  43-  (Suppl.)  S258  -S258  2011/05  [Not refereed][Not invited]
  • 谷口 祐子, 長嶋 雅子, 森 雅人, 森本 哲, 門田 行史, 五味 玲, 坂谷 貴司, 山形 崇倫, 桃井 真里子  脳と発達  43-  (Suppl.)  S286  -S286  2011/05  [Not refereed][Not invited]
  • 井上 元子, 山形 崇倫, 門田 行史, 英 雅世, 森 雅人, 福田 冬季子, 野崎 靖之, 長嶋 雅子, 杉江 秀夫, 桃井 真里子  脳と発達  43-  (Suppl.)  S289  -S289  2011/05  [Not refereed][Not invited]
  • 門田 行史, 檀 一平太, 長嶋 雅子, 渡辺 英寿, 山形 崇倫, 桃井 真里子  脳と発達  43-  (Suppl.)  S339  -S339  2011/05  [Not refereed][Not invited]
  • 乳腺炎に起因したと考えられる遅発型B群溶連菌髄膜炎の1症例
    長嶋 雅子, 門田 行史, 宮内 彰彦, 勝部 奈都子, 福田 冬季子, 山形 崇倫, 桃井 真里子  日本小児科学会雑誌  114-  (7)  1095  -1096  2010/07  [Not refereed][Not invited]
  • 門田 行史, 森 雅人, 山形 崇倫, 長嶋 雅子, 福田 冬季子, 杉江 秀夫, 桃井 真里子  脳と発達  42-  (Suppl.)  S226  -S226  2010/05  [Not refereed][Not invited]
  • 杉山 奈都子, 長嶋 雅子, 門田 行史, 野崎 靖之, 福田 冬季子, 森 雅人, 山形 崇倫, 杉江 秀夫, 桃井 真里子  脳と発達  42-  (Suppl.)  S291  -S291  2010/05  [Not refereed][Not invited]
  • 宮内 彰彦, 杉山 奈都子, 長嶋 雅子, 門田 行史, 野崎 靖之, 福田 冬季子, 森 雅人, 山形 崇倫, 杉江 秀夫, 桃井 真里子  脳と発達  42-  (Suppl.)  S291  -S291  2010/05  [Not refereed][Not invited]
  • 池田 尚広, 冨士根 明雄, 門田 行史, 福田 冬季子, 山形 崇倫, 杉江 秀夫, 桃井 真里子  脳と発達  42-  (Suppl.)  S292  -S292  2010/05  [Not refereed][Not invited]
  • 齋藤 真理, 山形 崇倫, 森 雅人, 門田 行史, 長嶋 雅子  脳と発達  42-  (Suppl.)  S299  -S299  2010/05  [Not refereed][Not invited]
  • 心肺補助循環(ECMO)を用いて救命しえた劇症型心筋炎の1症例
    片岡 功一, 門田 行史, 谷口 周平, 森本 康子, 南 孝臣, 村上 智明, 白石 裕比湖, 多賀 直行, 竹内 護, 立石 篤史, 河田 政明, 坪井 龍生, 桃井 真里子  日本小児科学会雑誌  114-  (5)  904  -904  2010/05  [Not refereed][Not invited]
  • 門田 行史, 山形 崇倫  小児科診療  73-  (増刊)  792  -794  2010/04  [Not refereed][Not invited]
  • 門田 行史, 山形 崇倫, 福田 冬季子, 森 雅人, 杉江 秀夫, 桃井 真里子  小児科臨床  63-  (2)  265  -270  2010/02  [Not refereed][Not invited]
     
    小児および若年性欠神てんかんは、特発性全般てんかんに分類されているが、欠神てんかんのなかに前頭葉欠神と呼ばれる、発作焦点が前頭領域に推定される一群が存在することが知られている。欠神てんかんに複雑部分発作を合併し、前頭葉欠神と考えられる男児例を経験した。本例は、2歳6ヵ月時に欠神発作が出現し、過呼吸で誘発される3Hzの全汎性棘徐波複合があり、9歳時に意識減損、姿勢発作を伴う複雑部分発作を示し、発作間歇期脳波では左右独立した前頭部棘波や前頭部を起始として急速に全汎化する3Hz棘徐波複合を認めた。前頭葉欠神は、年齢により発作型/病態が異なると考えられ、どの時期にどの治療薬を選択するか、治療法を検討する必要がある。(著者抄録)
  • 欠神てんかんに複雑部分発作を合併した男児例
    門田 行史, 山形 崇倫, 福田 冬季子, 森 雅人, 杉江 秀夫, 桃井 真里子  てんかん研究  27-  (3)  442  -442  2010/01  [Not refereed][Not invited]
  • ステロイド投与を行ったインフルエンザ脳症のまとめ
    川又 竜, 柳下 恵子, 門田 行史, 大木 丈弘, 菊池 豊, 三浦 琢磨, 山形 崇倫, 桃井 真里子  日本小児科学会雑誌  110-  (9)  1298  -1298  2006/09  [Not refereed][Not invited]
  • ジゴキシンが有効だった多源性心房性頻拍症の1例
    川又 竜, 大木 丈弘, 柳下 恵子, 門田 行史, 菊池 豊, 三浦 琢磨, 白石 裕比湖, 桃井 真里子  日本小児科学会雑誌  110-  (5)  713  -714  2006/05  [Not refereed][Not invited]
  • 感染を繰り返し頻回の入院が必要な乳幼児の臨床的検討 免疫グロブリン値を中心に
    柳下 恵子, 伊東 岳峰, 門田 行史, 大木 丈弘, 菊池 豊, 三浦 琢磨, 桃井 真里子  日本小児科学会雑誌  110-  (1)  65  -65  2006/01  [Not refereed][Not invited]
  • 栃木県における小児救急医療体制の現状と展望
    三浦 琢磨, 伊東 岳峰, 田村 大輔, 門田 行史, 節家 麻理子, 菊池 豊, 桃谷 孝之, 井原 正博, 小林 靖明, 桃井 真里子  栃木県医学会々誌  35-  38  -42  2005/10  [Not refereed][Not invited]
     
    栃木県の10医療圏および16基幹病院から得た小児救急医療体制に関するアンケート回答をまとめた.初期救急に関しては,夜間休日診療所は6ヶ所整備されていたが,365日24時間対応できるのは1ヶ所のみであった.輪番制は各医療圏で異なり,毎日行っているのは2医療圏のみで,まったく一次救急に対応していない医療圏が1ヶ所あった.二次救急は9医療圏で対応病院があり,三次救急は5病院が対応していた.各医療圏の整備状況と問題点を那須,芳賀,宇都宮,その他に分けて検討したところ,那須と芳賀では現在の体制の存続が危ぶまれている状況が浮き彫りとなった
  • 骨髄移植が行われたX染色体連鎖副腎白質ジストロフィの1例
    門田 行史, 伊東 岳峰, 節家 麻理子, 菊池 豊, 三浦 琢磨, 佐竹 修一, 野中 航仁, 今井 恵子, 金井 孝裕, 森 雅人, 郡司 勇治, 桃井 真里子, 松本 正栄, 矢部 晋正, 矢部 みはる  日本小児科学会雑誌  109-  (7)  923  -923  2005/07  [Not refereed][Not invited]
  • 児童養護施設で集団発生したマイコプラズマ感染症
    門田 行史, 森本 康子, 田村 大輔, 菊池 豊, 三浦 琢磨, 桃井 真里子  日本小児科学会雑誌  108-  (7)  1006  -1006  2004/07  [Not refereed][Not invited]
  • 江上 聡, 河原崎 秀雄, 牧野 駿一, 水田 耕一, 菱川 修司, 北 嘉昭, 宇野 武治, 後藤 珠子, 飯野 真由, 矢田 ゆかり, 高橋 尚人, 本間 洋子, 桃井 真里子, 門田 行史  日本小児外科学会雑誌  40-  (1)  114  -114  2004/02  [Not refereed][Not invited]
  • 新生児期に発症した特発性間質性肺炎の1例
    伊東 岳峰, 矢田 ゆかり, 高橋 尚人, 本間 洋子, 小池 泰敬, 森本 康子, 門田 行史, 加藤 佐代子, 桃井 真里子  日本小児科学会雑誌  107-  (11)  1562  -1562  2003/11  [Not refereed][Not invited]
  • 心室中隔欠損根治手術後5年を経過して発症した収縮性心膜炎の1例
    副島 典子, 門田 行史, 永井 真由美, 市橋 光, 白石 裕比湖, 桃井 真里子  日本小児科学会雑誌  107-  (9)  1271  -1271  2003/09  [Not refereed][Not invited]
  • 眼窩腫瘍として発症した急性リンパ性白血病の1症例
    門田 行史, 尾上 彰則, 糸長 伸能, 山内 忠彦, 菊池 豊, 郡司 勇司, 桃井 真里子  日本小児科学会雑誌  107-  (8)  1134  -1134  2003/08  [Not refereed][Not invited]

Industrial Property Rights

Awards & Honors

  • 2021/05 自治医科大学小児科学 第63回日本小児神経学会学術集会 優秀口演賞
     光トポグラフィー検査を用いたAD/HDに対するグアンファシン(GXR)の脳機能学的薬理作用の可視化 
    受賞者: 池田尚広、門田行史、井上あかり、Stephanie Sutoko、徳田竜也、橋本珠緒、田中大輔、牧敦、山形崇倫、檀一平太
  • 2021/05 自治医科大学小児科学 第63回日本小児神経学会 優秀English session賞
     Potential of practical Internet-delivered Parent-child Interaction Therapy in the COVID-19 era 
    受賞者: 倉根超、俣野美雪、山形崇倫、門田行史
  • 2019 自治医科大学小児科学 第61回日本小児神経学会学術集会 Excellent presentation Award
     
    受賞者: 池田、門田、長嶋、檀、山形
  • 2018 自治医科大学小児科学 Hypoactivation of the Right Prefrontal Cortex Underlying Motor‐Related Inhibitory Deficits in Children with Autism Spectrum Disorder: A Functional Near‐Infrared Spectroscopy Study
     Hypoactivation of the Right Prefrontal Cortex Underlying Motor‐Related Inhibitory Deficits in Children with Autism Spectrum Disorder: A Functional Near‐Infrared Spectroscopy Study 
    受賞者: Takahiro Ikeda;Tatsuya Tokuda;Yukifumi Monden;Masahiro Hirai;Sakae G. Mizushima;Masako Nagashima;Yasushi Kyutoku;Takamichi Taniguchi;Hideo Shimoizumi;Ippeita Dan;Takanori Yamagata
  • 2017 中央大学理工学部、自治医科大学小児科学 Neuroscience 2017 Junior Investigator Poster Award
     
    受賞者: 徳田、池田、門田、檀
  • 2016 自治医科大学小児科学 14th Asian and Oceanian Congress of Child Neurology Outstanding Award
     
    受賞者: 池田、門田、長嶋、檀、山形
  • 2015 自治医科大学小児科学 第57回日本小児神経学会総会・優秀演題賞
     
    受賞者: 長嶋、門田、山形、檀
  • 2014 自治医科大学小児科学 第56回日本小児神経学会総会・優秀演題賞
     
    受賞者: 長嶋、門田、檀、山形
  • 2013 自治医科大学小児科学 第53回 日本小児神経学会総会・優秀口演賞
     
    受賞者: 門田、檀、長嶋、山形

Research Grants & Projects

  • Exploration of tDCS-based ADHD treatment
    Japan Society for the Promotion of Science:Grants-in-Aid for Scientific Research Grant-in-Aid for Early-Career Scientists
    Date (from‐to) : 2019/04 -2022/03 
    Author : 門田 行史
  • Program development for promoting adherence to ADHD treatment using fNIRS
    Japan Society for the Promotion of Science:Grants-in-Aid for Scientific Research Grant-in-Aid for Early-Career Scientists
    Date (from‐to) : 2018/04 -2022/03 
    Author : 池田 尚広
     
    本研究では、注意欠如・多動症(以下、ADHD)の治療アドヒアランス(患者による主体的な治療の継続性)向上のため、被験者本人及び家族へ、ADHDの特性を理解するための有効な情報提示方法の開発を目的とする。 その方法として、これまで提案者らの研究グループが開発してきた、脳機能検査法である光トポグラフィ―(fNIRS)を用いた、脳活動結果のフィードバックを行い、その結果として被験者の理解度が向上したかどうかを質問紙によって確認する。 昨年度までに研究体制を確立することができたため、本年度においては、実際のfNIRS検査及び、質問紙を用いた患者と家族のADHDの理解度評価の準備と先行的に少人数の被験者へ検査を行った。具体的には、本研究の研究計画書を倫理委員会へ申請し、ADHD児に対してfNIRS計測を行った。また、ADHD児とその家族に疾患理解度を検証するための質問紙に答えてもらった。検査や質問紙回答はまだ被験者が限られているため、今後、多数の被験者への実施を予定している。
  • 塩野義製薬株式会社 武田薬品工業株式会社:特定臨床研究
    Date (from‐to) : 2019/07 -2020/06 
    Author : 門田, 池田, 檀, 牧
  • エビデンスに基づく家族関係再構築支援プログラムの確立
    Japan Society for the Promotion of Science:Grants-in-Aid for Scientific Research Grant-in-Aid for Scientific Research (C)
    Date (from‐to) : 2017/04 -2020/03 
    Author : 福丸 由佳, 森田 展彰, 藤田 博康, 門田 行史, 水島 栄
     
    本研究は、里親家庭や離婚を経験する家庭を中心に、親子関係や夫婦関係といった家族の関係性再構築や関係性の改善に焦点をあてた支援プログラムを大人に向けて実践し、その効果を測定する中で、エビデンスに基づいた関係性構築に向けた支援プログラムを確立することを目的としている。2年目にあたる2018年度は、子育て支援の現場における親向けのCAREプログラムの実践と、離婚を経験した親に向けたFAITプログラムの実践を中心に行ったが、どちらの実践においても参加者数が限られたことに加えて、生理的指標を伴う効果測定についてはその実施が未だに難しく、成果報告に至るまでにはかなりの時間を要する状況である。 また、CAREは米国におけるファシリテーター制度の確立に伴い、日本での普及においても制度改変が迫られる等、実践を取り巻く環境整備にも力を入れる必要があった。こうした取り組みも含めて、日本におけるCAREの実践とこれまでの研究の状況、及び今後の課題について、国際学会において口頭発表を行った。さらに、関連する心理療法のPCITとの合同研究会を開催し、米国よりCAREの実践と研究の中心メンバーの一人でもあるDr.Gurwichを招聘して、基調講演やワークショップなどを企画した。これにより、現場で支援にあたる専門家も含め、最新の知見を共有する機会を得ることができた。 一方、FAITについては、昨年度に引き続き当事者向けの実践と並行して支援者支援の観点も含めた専門家向けの研修を複数回実施すると共に、今後の実践や研究に向けた課題などについて調査を行った。これらの結果を日本離婚・再婚子ども研究学会の研究会で発表した。
  • fNIRSを用いたADHDの小児から成人までの治療予後判定因子と新治療の確立(国際共同研究強化)
    日本学術振興会:科学研究費助成事業 国際共同研究加速基金(国際共同研究強化)
    Date (from‐to) : 2017 -2019 
    Author : 長嶋 雅子
  • Japan Society for the Promotion of Science:Grants-in-Aid for Scientific Research Grant-in-Aid for Young Scientists (B)
    Date (from‐to) : 2015/04 -2018/03 
    Author : Nagashima Masako
     
    We examined the neural substrate of the effects of methylphenidate (MPH) on inhibition control in medication-naive ADHD and ADHD with ASD children using fNIRS in a randomized, double-blind, placebo-controlled, crossover design. We investigated cortical activation in the right inferior or middle frontal gyrus (IFG/MFG). In the ADHD without ASD group, unmedicated children exhibited no activation in right IFG/MFG, but MPH medication led to increased right IFG/MFG activation. In the ADHD with ASD group, right IFG/MFG activation was observed before taking MPH, but MPH medication resulted in decreased right IFG/MFG activation. Behavioral assessment showed a significant improvement in both groups one month after oral administration of MPH. In cases where MPH was effective, these results suggest that ADHD with ASD is not simply a mixture of ADHD and ASD pure disorders, but rather that it has its own distinct neuropathology. We will examine cases in which MPH is ineffective as a next step.
  • 機能的近赤外分光分析診断法による注意欠如・多動症児支援システムの実装
    戦略的創造研究推進事業(社会技術研究開発):研究開発成果実装支援プログラム
    Date (from‐to) : 2015/10 -2018/03 
    Author : 檀一平太
  • Japan Society for the Promotion of Science:Grants-in-Aid for Scientific Research Grant-in-Aid for Young Scientists (B)
    Date (from‐to) : 2012/04 -2015/03 
    Author : NAGASHIMA Masako
     
    ADHD is characterized mainly by dysfunction in inhibition and attention. Methylphenidate (MPH) and Atomoxetine (ATX) have been recommended as a primary medication. We examined the pharmacological effects of MPH and ATX in ADHD children using fNIRS in a randomized, double-blind, placebo-controlled, crossover design during an inhibition and attention task. Firstly, our fNIRS-based measurements visualized both medications modulated hemodynamic responses in the right prefrontal cortex (rPFC) during an inhibition task while pre-medication and a placebo did not in ADHD. Secondly, we visualized MPH modulated hemodynamic responses in rPFC and ATX in rPFC and the right inferior parietal lobe (rIPL) during an attention task while pre-medication and a placebo did not in ADHD. Consequently, our studies reveal that the activation pattern in rIPL could serve as an objective neurobiological marker to differentiate the neuropharmacological effects of ATX and MPH on ADHD regarding attentional control.
  • Japan Society for the Promotion of Science:Grants-in-Aid for Scientific Research Grant-in-Aid for Young Scientists (B)
    Date (from‐to) : 2012/04 -2015/03 
    Author : MONDEN Yukifumi
     
    fNIRS is a noninvasive and unrestrictive method of functional neuroimaging. Making the most of fNIRS’s merits, we have explored the neural substrate of inhibitory and attentional controls in ADHD children. Firstly, our fNIRS-based measurements successfully visualized the hypoactivation pattern in the right prefrontal and parietal cortex during an inhibition and attention task in ADHD children compared with typically developing control at a group level using fNIRS. Secondly, we clarified a method of individual classification between ADHD and typically developing control children using fNIRS with high classification accuracy with 90% sensitivity. Finally, we explored neuropharmacological effect of ADHD medications using double-blinded placebo study. Then the reduction of right prefrontaland parietal activation was normalized after taking ADHD medications, such as MPH and ATX.
  • Japan Society for the Promotion of Science:Grants-in-Aid for Scientific Research Grant-in-Aid for Scientific Research (B)
    Date (from‐to) : 2011/04 -2014/03 
    Author : YAMAGATA Takanori, NAGATA Kouichi, MIRI Masato, NOZAKI Yasuyuki, NAKASHIMA Naomi, MONDEN Yukifumi, NAGASHIMA Masako, JINBO Eriko
     
    To detect the relating genes and the treatment of autism spectrum disorder (ASD), we analyzed ASD and intellectual disability patients for copy number variation and candidate gene mutation. Scaffolding proteins such as SHANK3 and LIN7A/B were detected as responsible gene. Lin7a/b were considered to have important role on neuronal development because neuronal cell movement and axon elongation were disturbed by blocking the expression of Lin7a/b in fetal brain. We previously detected gene mutations on the G-protein coupled receptors (GPCRs). Addition to them, mutations on secretin receptor gene that is one of the GPCR were detected. Expression of oxytocin and vasopressin were increased after intra-ventricular injection of secretin. These results indicated that scaffolding proteins and GPCRs closely related to ASD and the molecules relating to them were the targets for the treatment research.

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