Researchers Database

watanabe jun

    GastroenterologyCenter,SurgeryMedicine Research Associate
Last Updated :2021/12/07

Researcher Information



J-Global ID

Research Interests

  • Systematic review   Community medicine   general surgery   

Research Areas

  • Other / Other
  • Life sciences / Digestive surgery

Academic & Professional Experience

  • 2021/04 - Today  Jichi Medical UniversityDepartment of Surgery, Division of Gastroenterological, General and Transplant SurgeryAssistant Professor
  • 2020/04 - 2021/03  岩美町国民健康保険岩美病院内科
  • 2019/04 - 2020/03  鳥取県立中央病院外科
  • 2017/04 - 2019/03  鳥取市佐治町国民健康保険診療所医科
  • 2014/04 - 2017/03  岩美町国民健康保険岩美病院内科
  • 2012/04 - 2014/03  鳥取県立中央病院初期臨床研修


  • 2016/04 - 2020/03  Jichi Medical University  医科学研究科  博士課程
  • 2006/04 - 2012/03  Jichi Medical University  School of Medicine  医学科

Association Memberships

  • The Japanese Society of Gastroenterological Surgery   Japan Primary Care Association   The Japanese Society of Internal Medicine   Japan Surgical Society   

Published Papers

  • Jun Watanabe, Hiroyuki Teraura, Kenichi Komatsu, Hironori Yamaguchi, Kazuhiko Kotani
    International Journal of Environmental Research and Public Health 18 (23) 12703 - 12703 2021/12 [Refereed]
    Background: The prediction of at-home deaths has become an important topic in rural areas of Japan with an advanced aging society. However, there are no well-established predictors to explain how these factors influence intention. This study aims to investigate the possible predictors of at-home death for cancer patients in rural clinics in Japan. Methods: This is a nationwide cross-sectional survey. A self-administered questionnaire was sent to 493 rural clinics in Japan. The main outcome was the realization of at-home deaths for cancer patients. Results: Among the 264 clinics (54%) that responded to the survey, there were 194 clinics with the realization of at-home death. The use of a clinical pathway (adjusted odds ratio 4.19; 95% confidence interval 1.57–11.19) and the provision of organized palliative care (adjusted odds ratio 19.16; 95% confidence interval 7.56–48.52) were associated with the prediction of at-home death, irrespective of island geography or the number of doctors and nurses. Conclusions: Having a clinical pathway and systematizing palliative care could be important to determine the possibility of at-home deaths for cancer patients in rural clinics in Japan.
  • Jun Watanabe, Kazuhiko Kotani, Alejandro Gugliucci
    Antioxidants 10 (12) 1891 - 1891 2021/11 [Refereed]
    Oxidative stress is a driving factor in the pathophysiology of chronic obstructive pulmonary disease (COPD). While paraoxonase 1 (PON1) is an antioxidant enzyme and a potential biomarker of this disease, data regarding the status of PON-1 in COPD are inconclusive. In this regard, to shed light on this issue, we performed a meta-analysis of data on PON1 activity in COPD. Electronic databases (MEDLINE, Embase and CENTRAL) were searched for available studies on PON1 activity in patients with stable COPD published before October 2021. A meta-analysis was performed using random-effects models. Twelve studies (12 studies on paraoxonase and three on arylesterase) were identified. Patients with COPD had lower levels of paraoxonase activity (standard mean difference [SMD] −0.77, 95% confidence interval [CI] −1.35 to −0.18) and arylesterase activity (SMD −1.15, 95% CI −1.95 to −0.36) in comparison to healthy controls. In subgroup analyses, paraoxonase activity was lower in patients of studies as consisted of mainly non-severe COPD (SMD −1.42, 95% CI −2.04 to −0.79) and, by contrast, slightly higher in patients of studies including severe COPD (SMD 0.33, 95% CI 0.02 to 0.64) in comparison to healthy controls. Arylesterase activity showed a similar trend. Overall, PON1 activity was lower in patients with COPD, suggesting that PON1-related antioxidant defense is impaired in COPD. Future studies are warranted.
  • Kengo Mukuda, Jun Watanabe
    Surgeries 2 (3) 335 - 346 2021/09 [Refereed]
    Punch incision is an alternative to elliptical excision for treating epidermal inclusion cysts, but its efficacy has not been systematically reviewed. This study assessed the efficacy and safety of punch incision versus elliptical excision for epidermal inclusion cysts. Randomized controlled trials published through January 2021 that evaluated the performance of punch incision versus elliptical excision on epidermal inclusion cysts were identified through electronic databases and clinical registries. Version 2 of the Cochrane risk-of-bias tool for randomized trials tool was used. Review Manager software was used for the meta-analysis. Two trials (100 participants) were identified. The primary outcomes were recurrence rate (risk ratio, 2.40; 95% confidence interval [CI], 0.37–15.60 [favoring elliptical excision]), mean operative time (mean difference [MD], −5.28; 95% CI, −12.72 to 2.16 [favoring punch incision]), and mean postoperative wound length (MD, −11.67; 95% CI, −20.59 to −2.76 [favoring punch incision]). The evidence was low to moderate due to the small sample size and its considerable heterogeneity. The use of punch incision shortened the mean postoperative wound length and had comparable safety to that of elliptical excision.
  • Jun Watanabe, Kazuhiko Kotani
    Cureus 2168-8184 2021/09 [Refereed]
    Abstract For colonoscopy, bowel preparation, especially that using polyethylene glycol (PEG) or senna, is performed among children with gastrointestinal disorders; however, it is not fully grounded in evidence. This study reviewed via meta-analyses the approaches to bowel preparation for colonoscopy in children. Electronic databases and trial registries were searched until April 2021. Quality assessment was conducted using the Grading of Recommendations, Assessment, Development, and Evaluation method. In total, three randomized controlled trials (318 patients) were identified. PEG was observed as a preferred protocol of bowel preparation compared with senna (risk ratio [RR] 1.35, 95% confidence interval [CI] 1.05-1.74; I2 = 15%). It was less painful than senna (RR 0.62, 95% CI 0.44-0.87; I2 = 0%). No serious adverse events were noted. Overall, the certainty of the evidence was low to moderate. PEG might be a preferred preparation agent for colonoscopy in children. Given the limited data, more studies are recommended.
  • Takeshi Yamashina, Noboru Hanaoka, Takeshi Setoyama, Jun Watanabe, Masahiro Banno, Hiroyuki Marusawa
    Cureus 2168-8184 2021/08 [Refereed]
  • Jun Watanabe, Tetsuro Aita, Kohei Saito, Yudai Iwasaki, Takeshi Fujieda, Takashi Yoshioka
    Chest 160 (2) e247 - e248 0012-3692 2021/08
  • Jun Watanabe, Tomohiro Osaki, Tadamasa Ueyama, Makoto Koyama, Masaru Iki, Kanenori Endo, Shigeru Tatebe, Yasuaki Hirooka
    World Journal of Surgery 0364-2313 2021/07 [Refereed]
  • Norio Yamamoto, Takahisa Ogawa, Masahiro Banno, Jun Watanabe, Tomoyuki Noda, Haggai Schermann, Toshifumi Ozaki
    European Journal of Trauma and Emergency Surgery 1863-9933 2021/07 [Refereed]
    PURPOSE: This study aimed to determine the efficacy and safety of cement augmentation for internally fixed trochanteric fractures through a systematic review and meta-analysis of randomized controlled trials (RCTs). METHODS: We searched the MEDLINE, EMBASE, Cochrane Central Register of Controlled Trials, World Health Organization International Clinical Trials Registry Platform, and databases to identify RCTs, published until July 2020 that examined the effects of cement augmentation of internal fixation of trochanteric fractures. The primary outcomes were reoperation and Parker Mobility Score, whereas the secondary outcomes were 1-year mortality rate, EuroQol 5 Dimension, fixation failures, and adverse events. We conducted meta-analyses of the outcome measures using the random-effects models. We evaluated the certainty of evidence based on the Cochrane risk-of-bias tool and the Grading of Recommendations, Assessment, Development, and Evaluation approach. RESULTS: We included three RCTs (326 participants). No significant effect was observed in favor of cement augmentation on all these outcomes. The certainty of evidence for fixation failures was very low and that for the other outcomes was low. The overall risk of bias for each outcome was high or of some concern in all included studies. CONCLUSIONS: The effect of cement augmentation of internal fixation of trochanteric fractures was uncertain for the clinical outcomes due to the low certainty of evidence. Further RCTs with a low risk of selection bias may present convincing conclusions on the efficacy and safety of cement augmentation. LEVEL OF EVIDENCE: Level 1.
  • Toshihide Izumida, Jun Watanabe, Ryo Yoshida, Kazuhiko Kotani
    World Journal of Cardiology 13 (5) 144 - 154 1949-8462 2021/05 [Refereed]
  • Jun Watanabe, Yoshitaka Iwazu, Kazuhiko Kotani
    Archives of Medical Science - Atherosclerotic Diseases 6 (1) 79 - 84 2451-0629 2021/04 [Refereed]
  • Kazuhiko Kotani, Jun Watanabe, Kouichi Miura, Alejandro Gugliucci
    Molecules 26 (8) 2323 - 2323 2021/04 [Refereed]
    Oxidative stress is involved in the pathophysiology of nonalcoholic fatty liver disease (NAFLD). However, reliable biomarkers of NAFLD in relation to oxidative stress are not available. While paraoxonase 1 (PON1) is an antioxidant biomarker, there appears to be mixed data on PON-1 in patients with NAFLD. The aim of this meta-analysis was to assess the current data on PON1 activity (i.e., paraoxonase and arylesterase) in patients with NAFLD. A PubMed, CENTRAL, and Embase search identified 12 eligible articles. In the meta-analysis, the paraoxonase activity was low in patients with NAFLD (mean difference (MD) −27.17 U/L; 95% confidence interval (CI) −37.31 to −17.03). No difference was noted in the arylesterase activity (MD 2.45 U/L; 95% CI −39.83 to 44.74). In a subgroup analysis, the paraoxonase activity was low in biopsy-proven nonalcoholic steatohepatitis (MD −92.11 U/L; 95% CI −115.11 to −69.11), while the activity in NAFLD as diagnosed by ultrasonography or laboratory data was similar (MD −2.91 U/L; 95% CI −11.63 to 5.80) to that of non-NAFLD. In summary, the PON1, especially paraoxonase, activity could be a useful biomarker of NAFLD. Further studies are warranted to ascertain the relevance of PON1 measurements in patients with NAFLD.
  • Tomoya Urakawa, Akihiro Saitsu, Jun Watanabe, Kazuhiko Kotani
    Journal of Cancer 12 (11) 3391 - 3392 2021/04 [Refereed]
  • Kazuoki Inoue, Jun Watanabe, Eiichi Kakehi
    Health and Quality of Life Outcomes 19 (1) 2021/03 
    AbstractThis letter was written to address two concerns about the results of the paper published by Zeynep et al. (BMC Health Qual Life Outcomes 18:265, 2020). First, the differences between the two groups in the environment with or without occupation may strengthen the primary outcome results. Second, lack of information on the complications and treatments of diabetes makes interpretation of the results difficult.
  • Jun Watanabe, Masato Hamasaki, Kazuhiko Kotani
    Journal of Clinical Medicine 10 (5) 904 - 904 2021/02 [Refereed]
    Introduction: Helicobacter pylori (H. pylori) infection is positively associated with cardiovascular diseases, but the involvement of lipids in this association remains unclear. The present study reviewed the changes in circulating lipid levels following H. pylori eradication. Methods: A PubMed database was searched until December 2020 to identify randomized control trials (RCTs) and non-RCTs investigating the effect of H. pylori eradication on the lipid levels in inverse variance-weighted, random-effects meta-analyses. Results: A total of 24 studies (four RCTs and 20 non-RCTs) with 5270 participants were identified. The post-eradication levels were increased for high-density lipoprotein cholesterol (HDL-C; mean difference (MD) 2.28 mg/dL, 95% confidence interval (CI) 1.90 to 2.66) and triglyceride (TG; MD 3.22 mg/dL, 95% CI 1.13 to 5.31) compared with the pre-eradication levels. H. pylori eradication resulted in little to no difference in the low-density lipoprotein-cholesterol levels (MD −2.33 mg/dL, 95% CI −4.92 to 0.26). In the analyses of RCTs only, the findings for elevated HDL-C levels, but not TG, were robust. Conclusions: H. pylori eradication increases the HDL-C levels. Further studies are needed to elucidate the effects of lipid changes following H. pylori eradication on cardiovascular diseases.
  • Jun Watanabe, Junya Shimamoto, Kazuhiko Kotani
    Antibiotics 10 (2) 156 - 156 2021/02 [Refereed]
    Background: Chronic spontaneous urticaria (CSU) is a disease with wheals and/or angioedema. Some drugs, especially antibiotics for Helicobacter pylori (H. pylori) eradication and the sulfone antibiotic dapsone, may be candidates for treating CSU. The present study assessed the efficacy of these antibiotic therapies for CSU. Methods: Databases (MEDLINE, the Cochrane Central Register of Controlled Trials, EMBASE, the World Health Organization International Clinical Trials Platform Search Portal and were searched until October 2020. Study selection, data abstraction and quality assessments were independently performed using the Grading of Recommendations Assessment, Development and Evaluation approach. The outcomes were the remission of CSU-related symptoms, activities and adverse events due to antibiotics for H. pylori eradication or dapsone. Results: Nine randomized controlled trials (RCTs; 361 patients) were included. The antibiotics for H. pylori eradication increased the remission rate (risk ratio (RR) = 3.99, 95% confidence interval (CI) = 1.31 to 12.14; I2 = 0%), but dapsone did not (RR = 1.15, 95% CI = 0.74 to 1.78). Antibiotics for H. pylori eradication (standard mean difference (SMD) = 1.49, 95% CI = 0.80 to 2.18; I2 = 69%) and dapsone (SMD = 7.00, 95% CI = 6.92 to 7.08; I2 = 0%) improved symptoms. The evidence of certainty was moderate. Dapsone was associated with mild adverse events, whereas H. pylori eradication was not. Conclusion: Antibiotics, especially those for H. pylori eradication, improved the remission rate and symptoms of CSU with few adverse events. Further studies are needed.
  • Jun Watanabe, Eiichi Kakehi, Masaru Okamoto, Shizukiyo Ishikawa, Yuki Kataoka
    Cochrane Database of Systematic Reviews 1 2021/02 [Refereed]
  • Jun Watanabe, Kazuhiko Kotani
    Archives of Medical Science 2021 [Refereed]
  • Kayoko Morio, Jun Watanabe, Yasushi Tsujimoto
    Supportive care in cancer : official journal of the Multinational Association of Supportive Care in Cancer 28 (12) 5589 - 5589 2020/12
  • Jun Watanabe, Joji Watanabe, Kazuhiko Kotani
    Medicina (Kaunas, Lithuania) 56 (12) 2020/11 [Refereed]
    Background: Endoscopic submucosal dissection (ESD) for gastric cancer is increasingly performed worldwide due to its efficacy and safety. This study aimed to assess the evidence of the impact of early vs. delayed feeding after ESD on quality of care, which remains to be fully determined. Methods: Electronic databases (PubMed, the Cochrane Central Register of Controlled Trials, EMBASE) and the trial registries (the World Health Organization International Clinical Trials Platform Search Portal and were searched for studies performed prior to September 2020. Study selection, data abstraction, and quality assessment were independently performed using the Grading of Recommendations Assessment, Development, and Evaluation approach. Self-rated satisfaction and hospital stay were chiefly analyzed. Results: Two randomized controlled trials (239 patients) were included. The early and delayed post-ESD feeding groups had similar rates of post-ESD bleeding (risk ratio 1.90, 95% CI 0.42 to 8.63; I2 = 0%). Early post-ESD feeding resulted in increased patients' satisfaction in comparison to delayed post-ESD feeding (standard mean difference (MD) 0.54, 95% CI 0.27 to 0.81; I2 = 0%) and reduced the length of hospital stay (MD -0.83, 95% CI -1.01 to -0.65; I2 = 0%). Conclusion: Early post-ESD feeding was associated with increased patients' satisfaction and reduced hospital stay in comparison to delayed feeding, while the rate of complications did not differ to a statistically significant extent. As we must acknowledge the limited number of reviewed studies, various trials regarding the quality of care are further needed to determine the benefits of early feeding after ESD.
  • Jun Watanabe, Tomohiro Osaki, Shigeru Tatebe, Keisuke Goto, Kanenori Endo, Seiichi Nakamura, Yasuaki Hirooka
    Clinical case reports 8 (11) 2255 - 2258 2020/11 [Refereed]
    We report a case of an encapsulated fat necrosis without significant medical history. To differentiate from liposarcoma, it should be recognized that a half of abdominal encapsulated fat necrosis cases have a history of inflammation and surgery.
  • Jun Watanabe, Kazuhiko Kotani
    Children (Basel, Switzerland) 7 (9) 2020/09 [Refereed]
    Early feeding after percutaneous endoscopic gastrostomy (PEG) placement is an accepted practice in the treatment of adult patients and the knowledge is clinically extrapolated in the treatment of children. To verify this treatment in children-as there are some specific features of PEG-related practices in children-the present study aimed to review meta-analyses of early feeding (within 4 h) after PEG placement in children. We searched the PubMed database for articles published until July 2020. A quality assessment was performed using the Grading of Recommendations, Assessment, Development, and Evaluation method. Three randomized controlled trials (208 patients) were eligible for inclusion. No patients died within 72 h. Early feeding resulted in little to no difference in the length of hospital stay (mean difference [MD] -7.47, 95% confidence interval [CI] -25.16 to 10.21; I2 = 95%) and vomiting events (risk ratio 0.84, 95% CI 0.55 to 1.31; I2 = 0%). In a subgroup analysis, early feeding without antibiotics reduced the length of hospital stay in one study (MD -21.60, 95% CI -22.86 to -20.34) but early feeding with antibiotics did not affect the length in two studies (MD 0.28, 95% CI -6.49 to 7.06; I2 = 0%). Overall, the certainty of the evidence was not very high. In summary, early feeding after PEG placement may be a safe alternative to delayed feeding in children. The findings in children seemed similar to those in adults, while there is a need for further studies that specifically investigate PEG placement-related practices in children.
  • Haruhiko Hoshino, Jun Watanabe, Masahiro Banno
    Journal of anesthesia 2020/08
  • Jun Watanabe, Daeho Park, Eiichi Kakehi, Kazuoki Inoue, Shizukiyo Ishikawa, Yuki Kataoka
    Endoscopy international open 8 (7) E848-E860  2020/07 [Refereed]
    Background and study aims  We aimed to assess the efficacy and safety of the starting position during colonoscopy. Patients and methods  We searched CENTRAL, MEDLINE, EMBASE, and the WHO International Clinical Trials Registry Platform through February 2019 to identify studies reporting the comparison between the right/supine/prone/tilt-down and left lateral starting position during colonoscopy. The primary outcomes were mean cecal insertion time and adverse events requiring medication. Two reviewers performed study selection and risk of bias assessment. We determined the quality of evidence using the Grading of Recommendations, Assessment, Development, and Evaluation method. This study was registered in PROSPERO (CRD42019124360). Results  We identified 10 randomized controlled trials (RCTs) (2083 participants), including three trials on right/tilt-down versus left, two trials on supine/prone versus left, respectively. Mean difference in mean cecal insertion time in supine versus left was -41.0 s (95 % confidence interval [CI] -57.3 to -24.7) in one study and in tilt-down versus left was - 37.3 s (95 % CI -72.1 to -2.4; I 2  = 58 %) in three studies; however, there were no statistically significant differences in prone/right versus left position (very low certainty of evidence). Four of eight studies noted adverse effects requiring medication (moderate certainty of evidence). One RCT applying the tilt-down position was terminated because of increased occurrence of oxygen desaturation. Conclusion  We could not conclusively determine the efficacy and safety of the starting position during colonoscopy because of low certainty of evidence. Further studies are needed to confirm the efficacy and safety of the starting potion during colonoscopy.
  • Jun Watanabe, Yusuke Ikegami, Ayumi Tsuda, Eiichi Kakehi, Takeshi Kanno, Shizukiyo Ishikawa, Yuki Kataoka
    Digestive endoscopy : official journal of the Japan Gastroenterological Endoscopy Society 2020/06 [Refereed]
    OBJECTIVES: There are two major methods for local anesthesia by lidocaine before upper gastrointestinal endoscopy: simple spray and viscous solution. We aimed to assess the efficacy and safety by meta-analysis between these two methods. METHODS: We searched PubMed, EMBASE, the Cochrane Central Register of Controlled Trials, World Health Organization International Clinical Trials Registry Platform, and databases through October 2019 to perform meta-analyses using random-effects models. The primary outcomes were participants' pain/discomfort, satisfaction, and anaphylactic shock. Three reviewers independently searched for articles, extracted data, and assessed the risk of bias. We evaluated the certainty of evidence based on the Grading of Recommendations, Assessment, Development, and Evaluation approach. This study was registered in PROSPERO (CRD42020155611). RESULTS: We included seven randomized controlled trials (2667 participants). The participants' pain/discomfort may be similar between the lidocaine spray and viscous solution [standardized mean difference 0.03, 95% confidence intervals (CI) -0.37 to 0.42; I2  = 93%; low certainty of evidence]. The lidocaine spray probably increased participants' satisfaction compared with the viscous solution (relative risk 1.22; 95% CI, 1.02 to 1.47; I2  = 47%; moderate certainty of evidence). No anaphylactic shock occurred in four studies (low certainty of evidence). Four studies had high risks of selection bias. CONCLUSION: The use of lidocaine spray for local anesthesia provided better satisfaction scores than the viscous solution, and both methods have the same effect with regards to the control of discomfort and pain. Further studies in large multicenter randomized controlled trials with a pre-registration protocol are needed.
  • Jun Watanabe, Eiichi Kakehi, Kazuhiko Kotani, Kazunori Kayaba, Yosikazu Nakamura, Shizukiyo Ishikawa
    Journal of clinical laboratory analysis 34 (3) e23087  2020/03 [Refereed]
    BACKGROUND: The cardiovascular relevance of isolated low levels of high-density lipoprotein cholesterol (HDL-C) is yet to be determined. Stroke often leads to long-term disability, and thus, not only stroke mortality but also stroke incidence is a topic of research. Although isolated low HDL-C level has been found to be a predictor for stroke mortality previously, whether it can predict stroke incidence is unknown. METHODS: In the Jichi Medical School cohort study, 11 025 community-living residents without a history of stroke were examined. Hazard ratios (HRs) for isolated and non-isolated low HDL-C levels were calculated relative to those for normal HDL-C levels in stroke patients using Cox's regression models. RESULTS: During the mean follow-up period of 10.7 years, 412 residents had their first-ever stroke. The multivariable-adjusted HRs for the levels of isolated and non-isolated low HDL-C were 1.11 (95% confidence interval, 0.85-1.44) and 1.35 (1.01-1.81), respectively, when compared to that for normal HDL-C. CONCLUSION: Low HDL-C levels with other dyslipidemias may contribute to the incidence of stroke, not isolated low HDL-C.
  • Jun Watanabe, Kanenori Endo, Yasutaka Tanaka, Keisuke Goto, Shoichi Urushibara, Tomohiro Osaki, Shigeru Tatebe, Seiichi Nakamura, Yasuaki Hirooka, Masahide Ikeguchi
    Yonago acta medica 63 (1) 47 - 54 2020/02 [Refereed]
    Background: Dynamic computed tomography (CT) angiography is useful for evaluating of hepatic vascularity. Although vasodilators increase hepatic blood flow, the utility of dynamic CT with vasodilators is unclear. Here we investigated the utility and safety of dynamic CT with vasodilators. Methods: A prospective case-control radiographic evaluation using abdominal dynamic CT with and without vasodilator was performed at a single center between October 2015 and September 2016. We compared the CT values in Hounsfield units of the aorta; celiac artery; and common, right, and left hepatic arteries in the arterial phase and the main trunk; right and left branches of the portal vein; and right, middle, and left hepatic veins in the portal phase with and without vasodilators. The region of interest was set in each element of the liver vasculature. Four radiological technologists independently and visually compared the scores of the portal vein (P-score) and hepatic vein (V-score) on a 5-point scale with and without vasodilators. Results: The CT values of arteries and veins using vasodilators were significantly higher than those without vasodilators. With and without vasodilators, the P-scores were 3.1 ± 1.2 and 4.0 ± 1.1 (P < 0.05) and the V-scores were 3.3 ± 1.4 and 4.3 ± 1.0 (P < 0.05). Only one patient with vasodilator use had transient hypotension and recovered immediately without medication. Conclusion: Dynamic CT with vasodilators can provides better visualization of vascular structures.
  • Jun Watanabe, Eiichi Kakehi, Kazuhiko Kotani, Kazunori Kayaba, Yosikazu Nakamura, Shizukiyo Ishikawa
    Asia-Pacific journal of public health 32 (1) 27 - 34 2020/01 [Refereed]
    We aimed to investigate the relationship between high-density lipoprotein cholesterol (HDL-C) concentration and the incident stroke subtypes. We enrolled 11 027 participants between the ages of 18 and 90 years without a history of stroke in 12 Japanese communities. Cox's regression models were used for stroke subtypes, adjusted for traditional risk factors, according to the categories based on HDL-C concentrations: 1.04 to 1.55 mmol/L, ≥1.56 mmol/L, and <1.03 mmol/L (as the reference). During a mean follow-up of 10.7 years, 412 stroke events had occurred. However, HDL-C was not significantly associated with the incidence of cerebral infarction and subarachnoid hemorrhage. High HDL-C concentration was associated with a decreased incidence of intracerebral hemorrhage in women (hazard ratio = 0.23; 95% confidence interval = 0.06-0.89), but not in men (hazard ratio = 0.73; 95% confidence interval = 0.27-1.97). Therefore, high HDL-C concentration might have a protective effect on the incidence of intracerebral hemorrhage, particularly in women.
  • Jun Watanabe, Kazuhiko Kotani
    Vascular health and risk management 16 149 - 155 2020 [Refereed]
    Background: The importance of management of metabolic syndrome (MetS) for risk reduction of cardiovascular disease (CVD) has been recognized worldwide. Because of the comparatively unique characteristics of bodily figure/obesity and incident CVD in Japan, the relevance of MetS on CVD can be still discussed among Japanese people. The present study aimed to review briefly the relationship of MetS with CVD morbidity/mortality among general Japanese people. Methods: Population-based prospective cohort studies evaluating the predictive value of MetS on CVD morbidity/mortality via a PubMed search up to 2019 were summarized. Results: We identified two studies on morbidity that reported MetS to predict CVD morbidity. We identified three studies on mortality, and these studies showed an increased direction of hazard ratio (HR) of CVD mortality, while one study reported an insignificant prediction of MetS for CVD mortality. In the meta-analysis method, MetS significantly predicted CVD morbidity (HR=1.71 [95% confidence interval=1.34-2.18] in men and HR=1.89 [95% confidence interval=1.45-2.46] in women) as well as CVD mortality (HR=1.68 [95% confidence interval=1.37-2.06] in men and HR=1.73 [95% confidence interval=1.39-2.15] in women). Conclusion: Among general Japanese people, MetS can be a positive predictor of CVD morbidity/mortality. Since the studies are limited, more research is needed to establish the findings.
  • Jun Watanabe, Masato Hamasaki, Kazuhiko Kotani
    Archives of medical sciences. Atherosclerotic diseases 5 e148-e152  2020 [Refereed]
    Introduction: Lipoprotein(a) (Lp[a]) is a risk factor of cardiovascular disease (CVD). Familial hypercholesterolemia (FH), which exhibits high low-density lipoprotein cholesterol (LDL-C) levels, is a risk factor of CVD. The relationship of Lp(a) with CVD has been characterized in populations specific to FH. Material and methods: Studies reporting on the relationship of Lp(a) with CVD among FH subjects via PubMed up to 2020 were reviewed. Results: Eight studies were identified as eligible. In the meta-analyses, a high Lp(a) level was significantly and predictively associated with CVD compared to a low Lp(a) level in 2 cross-sectional studies (odds ratio = 2.57; 95% confidence interval (CI): 1.16-5.73) and 6 cohort studies (risk/hazard ratio = 1.91; 95% CI: 1.50-2.43). The totally integrated relative risk of these studies was 1.97 (95% CI: 1.57-2.46). Conclusions: FH subjects with high Lp(a) levels can have a high CVD risk, and besides LDL-C, attention should be paid to Lp(a) levels in FH subjects.
  • Jun Watanabe, Eiichi Kakehi, Kazuhiko Kotani, Kazunori Kayaba, Yosikazu Nakamura, Shizukiyo Ishikawa
    Diabetology & metabolic syndrome 11 3 - 3 2019 [Refereed]
    Background: Metabolic syndrome (MetS) and cancer are major public health problems worldwide. The relationship between MetS and cancer death is of great interest. We examined the predictive value of MetS for cancer mortality in Japan. Methods: Study participants included 4495 men and 7028 women aged 18-90 years who were registered between 1992 and 1995 as part of the Jichi Medical School Cohort Study. We used a definition of MetS modified for the Japanese population. The primary outcome was cancer mortality. Additionally, the relationship between MetS and cancer-type specific mortality was examined. Analyses were conducted with Cox's regression models adjusted for age, smoking status, alcohol drinking status, marital status, educational attainment, physical activity, occupational category, and menopausal status (only in women). Results: During a mean follow-up of 18.5 years, 473 men and 297 women died from cancer. MetS was positively associated with cancer mortality in women (hazard ratio [HR], 1.69; 95% confidence interval [CI] 1.21-2.36), but not in men (HR, 1.21; 95% CI 0.90-1.62). Additionally, MetS was associated with a high risk of colorectal (HR, 3.48; 95% CI 1.68-7.22) and breast (HR, 11.90; 95% CI 2.25-62.84) cancer deaths in women. Conclusion: MetS was a significant predictor of cancer mortality in women.
  • Jun Watanabe, Kengo Nishimura, Shigeto Miyasaka, Keisuke Morimoto, Takafumi Hamasaki, Shingo Ishiguro
    The International journal of angiology : official publication of the International College of Angiology, Inc 25 (5) e135-e138  2016/12 [Refereed]
    Heparin-induced thrombocytopenia (HIT) is still a relatively uncommon condition and it is not well known how to administer argatroban during continuous hemodiafiltration (CHDF). A 72-year-old man required CHDF with heparin because of the oliguria and hyperpotassemia directly after the open repair of a juxtarenal abdominal aortic aneurysm. As the postoperative blood platelet count dropped and there was a thrombus in the CHDF circuit, HIT was suspected and nafamostat mesilate, but not heparin, was immediately administered for CHDF. As heparin-platelet factor 4 complex was positive, we diagnosed him with HIT and started argatroban while monitoring the activated clotting time (ACT), resulting in no further obstruction of the CHDF and an increase in the platelets. There was no disadvantage for administering nafamostat mesilate which we have commonly used instead of heparin, we should have used argatroban once we suspected HIT. It may be important to consider the history of heparin especially in administering heparin and it may be useful to monitor the ACT when initially starting argatroban for patients with HIT.

Conference Activities & Talks

  • 渡部純
    第14回へき地・地域医療学会  2021/06 
    近年ジェネラルマインドによる地域医療だけでなく、リサーチマインドを持つ重要性が注目されている。今回、地域医療におけるリサーチマインドの意義ついて述べる。 私は地域病院、一人診療所での地域医療を背景にし、ジェネラルマインドの重要性を学んだ。地域医療で従事する中で、メタボリックシンドロームに重点を置いた特定健診と、悪性腫瘍の早期発見を目的としたがん検診を有効活用することが重要だと考えた。地域で出た疑問で、自治医科大学の社会人大学院に入学し、医学博士を「日本人一般住民におけるメタボリックシンドロームと悪性腫瘍死亡—Jichi Medical School (JMS)コホート研究—」で取得し、メタボの人は悪性腫瘍の予防と管理が必要であることを示唆した。加えて、地域の実臨床で生じた疑問を解決すべく、コクランメンバーとしてシステマティックレビューを行っており、エビデンスの実臨床への還元を目指している。 地域医療では専門医では生じない幅広い分野に渡る臨床疑問が生まれる。リサーチマインドを持って地域で出た疑問を解決することにより、科学的に地域を俯瞰し、地域医療を深化させることができる。
  • Sporadic pancreatic neuroendocrine tumors including an insulinoma: A case report
    Jun Watanabe, Kanenori Endo, Keisuke Goto, Shoichi Urushibara, Tomohiro Osaki, Shigeru Tatebe, Seiishi Nakamura, Yasuaki Hirooka
    第33回日本内視鏡外科学会総会  2021/03
  • 高齢者胃癌に対する腹腔鏡下胃切除術
    渡部 純, 尾﨑 知博, 建部 茂, 後藤 圭佑, 漆原 正一, 遠藤 財範, 中村 誠一, 池口 正英
    第32回日本内視鏡外科学会総会  2019/12
  • 十二指腸腺腫に対するD-LECSの経験
    渡部 純, 尾﨑 知博, 柳谷 淳志, 岩本 拓, 田中 究, 後藤 圭佑, 漆原 正一, 遠藤 財範, 建部 茂, 中村 誠一, 池口 正英
    第94回中四国外科学会総会・第24回中国四国内視鏡外科研究会  2019/09
  • 血管拡張薬を用いた肝切除術前Dynamic CTの有用性の検討
    渡部 純, 遠藤 財範, 中村 誠一
    第74回日本消化器外科学会総会  2019/07
  • 誘因なく発症した被包化脂肪壊死の一例
    渡部 純, 尾﨑 知博, 建部 茂, 後藤 圭佑, 漆原 正一, 遠藤 財範, 中村 誠一, 池口 正英
    第143回山陰外科集団会  2019/06
  • High-Density Lipoprotein Cholesterol and Stroke Subtypes Incidence: JMS cohort Study
    Jun Watanabe
    第29回日本疫学会学術総会  2019/01
  • メタボリックシンドロームと総死亡―Jichi Medical School (JMS)コホートⅠ研究―
    渡部 純, 石川鎮清,小谷和彦,中村好一
    第76回日本公衆衛生学会総会  2017/11
  • 総胆管結石症に対する腹腔鏡・内視鏡合同手術(LECS)の経験
    渡部純, 仁井陸冬, 花木武彦, 木原恭一, 遠藤財範, 鈴木一則, 中村誠一, 澤田隆, 清水哲, 池口正英
    第138回山陰外科集団会  2016/11
  • 傍腎動脈腹部大動脈瘤術後HITを発症した1例
    渡部純, 西村謙吾, 万木洋平, 松村安曇, 宮坂成人, 前田啓之, 森本啓介
    第131回山陰外科集談会  2013/06
  • Erlotinibが有効であった肺癌による癌性髄膜炎の1例
    渡部純, 浦川賢, 澄川崇, 陶山久司, 中安弘幸, 杉本勇二
    第107回日本内科学会中国地方会  2012/11
  • 劇症型溶連菌感染症による敗血症性ショックー両側膿胸に対するドレナージー
    第31回山陰救急医学会  2012/09

Awards & Honors

  • 2021/06 へき地・地域医療学会 第14回へき地医療功労者賞
    受賞者: 渡部純
  • 2017/11 日本公衆衛生学会 第76回日本公衆衛生学会口演賞

Academic Contribution

  • 国際学会誌World Journal of Gastrointestinal Surgery査読
    Date (from-to) :2021/09
    Role: Peer review
    Type: Peer review etc
  • 国際学術誌Nutrients査読
    Date (from-to) :2021/09
    Role: Peer review
    Type: Peer review etc
  • 国際学術誌Journal of Clinical Laboratory Analysis査読
    Date (from-to) :2021/04
    Role: Peer review
  • 国際学術誌Antibiotics査読
    Date (from-to) :2021/04
    Role: Peer review
  • 国際学術誌World Journal of Gastroenterology査読
    Date (from-to) :2021/01
    Role: Peer review
    Type: Peer review etc
  • 国際学術誌Medicina査読
    Date (from-to) :2021/01
    Role: Peer review
  • 国際学術誌Children査読
    Date (from-to) :2020/12
    Role: Peer review
    Type: Peer review etc
  • 国際学術誌Journal of Clinical Laboratory Analysis査読
    Date (from-to) :2019/09
    Role: Peer review

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