Researchers Database

yamamoto hironori

    InternalMedicineGastroenterology Professor
Last Updated :2022/11/26

Researcher Information

URL

J-Global ID

Research Interests

  • 小腸内視鏡   小腸内視鏡検査   小腸出血   小腸病学   内視鏡治療   消化器内視鏡   腸内細菌叢   小腸腫瘍   内視鏡検査   ダブルバルーン内視鏡   小腸疾患   Helicobacter pylori   小腸   小腸ダブルバルーン内視鏡検査   小腸細菌叢   嫌気性菌   通性菌   細菌叢   嫌気培養   

Research Areas

  • Life sciences / Gastroenterology

Academic & Professional Experience

  • 2007  Jichi Medical UniversitySchool of Medicine教授

Published Papers

  • JW Pike, H Yamamoto, NK Shevde
    ADVANCES IN RENAL REPLACEMENT THERAPY 9 (3) 168 - 174 1073-4449 2002/07 [Refereed][Not invited]
     
    Lipophilic hormones of steroidal origin such as the sex hormones and 1,25-dihydroxy vitamin D-3 (1,25[OH](2)D-3) function by regulating patterns of gene expression in cells. The mediators of such actions are nuclear receptors that recognize these ligands with high affinity and selectivity and function through several mechanisms as gene specific transcription factors. As a result of the mechanistic complexity of nuclear receptor action, recent studies have revealed that both synthetic analogs as well as novel mimetics of a receptor's natural hormonal ligand are capable of modulating functional responses in both cell- and gene-selective manners. These findings have given rise to the term selective receptor modulators, typified by such synthetic estrogen receptor ligands as tamoxifen and raloxifene. A number of vitamin D analogs have been prepared that appear to exhibit tissue-selective activity-most notable through their inability to induce levels of hypercalcemia typical of the activity of the natural hormone 1,25(OH)(2)D-3. Because this debilitating yet normal feature of the natural ligand limits its usefulness in a variety of clinical indications, including its application to prevent bone disease caused by secondary hyperparathyroidism, this feature of many of the new analogs is especially welcome. This article discusses what constitutes a selective receptor modulator and whether the current vitamin D analogs represent such entities. (C) 2002 by the National Kidney Foundation, Inc.
  • N Kashiwagi, K Sugimura, H Koiwai, H Yamamoto, T Yoshikawa, AR Saniabadi, M Adachi, T Shimoyama
    DIGESTIVE DISEASES AND SCIENCES 47 (6) 1334 - 1341 0163-2116 2002/06 [Refereed][Not invited]
     
    Our aim was to understand the mechanism of immunological changes associated with the use of an adsorptive-type extracorporeal device (Adacolumn) that has been developed for selective adsorption of granulocytes and monocytes/macrophages from peripheral blood of patients with active ulcerative colitis. The column is filled with carriers (G-1 beads) that have a diameter of 2 mm and are made of cellulose diacetate. In peripheral blood treated with the G-1 beads or peripheral blood from patients with active ulcerative colitis following granulocyte and monocyte adsorption apheresis, a significant suppression of proinflammatory cytokines (tissue necrosis factor-alpha, interleukin-1beta, interleukin-6, and interleukin-8) production by leukocytes, neutrophil chemotaxis, down-regulation of leukocyte adhesion molecule (L-selectin) and neutrophil adhesion to interleukin-1beta-activated endothelial cells were observed. Furthermore, after granulocyte adsorption therapy, the number of CD10-negative premature granulocytes increased, indicating increased turnover of these cells in the circulation. Our observations suggest that selective granulocyte and monocyte adsorption is associated with modified peripheral blood leukocyte function favorable to patients with ulcerative colitis and possibly other autoimmune disorders which reflect leukocyte hyperactivity.
  • E Takeda, K Sakamoto, K Yokota, M Shinohara, Y Taketani, K Morita, H Yamamoto, K Miyamoto, M Shibayama
    JOURNAL OF NUTRITIONAL SCIENCE AND VITAMINOLOGY 48 (2) 102 - 108 0301-4800 2002/04 [Refereed][Not invited]
     
    The awareness of phosphorus intake is important because hyperphosphatemia and hypophosphatemia both impair bone metabolism. Phosphorus consumption from food was obtained from values in the Food Balance Sheet (FBS) of Japan from 19 60 to 1995. The amounts of phosphorus calculated from the FBS increased gradually from 1,243 mg/d in 1960 to 1,332 mg/d in 1975 and to 1,421 mg/d in 1995. This is explained by the increased consumption of cow's milk and milk products, meat, and chicken eggs. The main foods supplying phosphorus in 1995 were cereals, milk and milk products, fishes and shellfishes, and vegetables; their contributions were 24.4, 15.8, 14.2, and 10.9%, respectively. The phosphorus-to-calcium ratio calculated from the FBS was 3.5.1. in 1960, which decreased to 2.89 in 1975 and 2.44 in 1995. Therefore total phosphorus consumption in 1995 was presumably more than 1,500 mg/d when imported food containing phosphorus and the consumption of phosphorus-containing food additives in Japan are also considered. These findings suggest that the phosphorus consumption estimated from the FBS is increasing and that more attention should be paid to the maintenance of healthy bones in Japan, where the average amount of calcium intake is less than 600 mg/d.
  • Nagashima T, Hirata D, Yamamoto H, Okazaki H, Minota S
    American journal of kidney diseases : the official journal of the National Kidney Foundation 5 37 E38  0272-6386 2001/05 [Refereed][Not invited]
  • H Yamamoto, Y Sekine, Y Sato, T Higashizawa, T Miyata, S Iino, K Ido, K Sugano
    GASTROINTESTINAL ENDOSCOPY 53 (2) 216 - 220 0016-5107 2001/02 [Refereed][Not invited]
     
    Background: Deep insertion of an enteroscope by use of a push technique is difficult. A new method of enteroscopy was developed, a double-balloon method, to improve the access to the small intestine. Methods:The new method uses 2 balloons, one attached to the tip of the endoscope and another at the distal end of an overtube. By using these balloons to grip the intestinal wall, the endoscope can be inserted further without forming redundant loops in the small intestine. This method was tried with a standard upper endoscope in 3 patients and with a longer enteroscope in 1 patient. Results: Despite its short length the upper endoscope was successfully inserted as far as 30 to 50 cm beyond the ligament of Treitz in the 3 patients. In the fourth patient the longer enteroscope was successfully inserted beyond the ileo-cecal valve. Conclusions: The double-balloon method facilitates endoscopic access to the small intestine.
  • H Yamamoto, H Koiwai, Y Sekine, F Sunada, S Iino, K Ido, K Sugano
    GASTROINTESTINAL ENDOSCOPY 52 (5) 678 - 681 0016-5107 2000/11 [Refereed][Not invited]
  • H Yamamoto, T Yamada, Y Itoh
    CLINICAL CHEMISTRY AND LABORATORY MEDICINE 38 (6) 495 - 499 1434-6621 2000/06 [Refereed][Not invited]
     
    Instability of beta(2)-microglobulin in acidic urine was investigated by identifying an associated protease from normal urine. Degradation was completely blocked by pepstatin, an aspartic protease inhibitor, and the counterpart of the inhibitor was thus sought. The molecular weight of the counterpart was similar to that of the inhibitor, while its cleavage site on beta(2)-microglobulin was identical in three products generated in purified beta(2)-microglobulin in normal acidified urine (pH 5.0-5.5) and those generated by direct reaction between puri fled beta(2)-microglobulin and cathepsin D in acetic acid (pH 5.0). On Western blotting, the presence of cathepsin D was demonstrated immunochemically in urine, and its urinary concentration correlated well with degree of beta(2)-microglobulin degradation. All these findings strongly suggest that cathepsin D is a major urinary acid protease involved in the degradation of beta(2)-microglobulin.
  • H Yamamoto, H Koiwai, T Yube, N Isoda, Y Sato, Y Sekine, T Higashizawa, K Utsunomiya, K Ido, K Sugano
    GASTROINTESTINAL ENDOSCOPY 50 (5) 701 - 704 0016-5107 1999/11 [Refereed][Not invited]
  • H Yamamoto, T Yube, N Isoda, Y Sato, Y Sekine, T Higashizawa, K Ido, K Kimura, N Kanai
    GASTROINTESTINAL ENDOSCOPY 50 (2) 251 - 256 0016-5107 1999/08 [Refereed][Not invited]
     
    Background: Saline-assisted endoscopic resection is an established therapeutic method. However, it is sometimes difficult to maintain a desired level of tissue elevation after injection of saline. Therefore we decided to use a mucinous substance such as sodium hyaluronate instead of saline. Methods: Two resected porcine stomachs and five dogs were used for the study. The elevations, made by submucosal injections of sodium hyaluronate, were compared with those produced with normal saline. Sodium hyaluronate-assisted mucosal resections were compared with the saline-assisted resections. Results: Mucosal elevations created by submucosal injections of sodium hyaluronate remained for a longer time with a clearer margin compared to those made by saline injection. Endoscopic mucosal resections were performed safely with the assistance of sodium hyaluronate. Conclusions: Use of sodium hyaluronate instead of saline for endoscopic mucosal resection could make the procedure easier and more reliable.
  • K Kihira, K Satoh, K Saifuku, Y Taniguchi, T Takimoto, H Yamamoto, K Ido, Y Yoshida, K Kimura
    ALIMENTARY PHARMACOLOGY & THERAPEUTICS 11 (3) 511 - 514 0269-2813 1997/06 [Refereed][Not invited]
     
    Aim: To evaluate the efficacy and safety of two 1-week low-dose triple-therapy drug regimens involving antisecretory drugs for Helicobacter pylori infection, 99 patients with H. pylori infection were treated with either lansoprazole or ranitidine used together with clarithromycin and metronidazole. Methods: The drug combination and administration periods in the proton pump inhibitor group were lansoprazole 30 mg o.m., clarithromycin 200 mg b.d. and metronidazole 250 mg b.d., all given for 7 days (LCM group). The ranitidine group received ranitidine 150 mg b.d., clarithromycin 200 mg b.d. and metronidazole 250 mg b.d. also for 7 days (RCM group). The presence or absence of H. pylori was determined from gastric biopsy specimens taken from both the antrum and the body, by smear, culture and tissue section (Giemsa stain). Cure was defined as failure to find evidence of H. pylori infection 4 weeks after antimicrobial therapy had ended. Results: The cure of H. pylori infection was 88% in the LCM group (44 of 50;95% confidence interval (CI) = 79-97%) and 92% in the RCM group (45 of 49; 95% CI = 84-99%). The incidence of adverse events was 16% and 18% for the two groups, respectively. Conclusions: No significant differences in cure rate and safety profiles were noted between the two regimens, suggesting that moderate acid inhibition using an H-2-blocker is sufficient to achieve optimal H. pylori eradication.
  • K Ido, H Yamamoto, C Kawamoto, H Koiwai, Y Yoshida, K Kimura
    GASTROINTESTINAL ENDOSCOPY 45 (5) 420 - 423 0016-5107 1997/05 [Refereed][Not invited]
  • K Kihira, K Satoh, K Saifuku, Y Taniguchi, T Takimoto, Y Yoshida, Y Ishino, H Yamamoto, K Kimura
    JOURNAL OF GASTROENTEROLOGY 31 66 - 68 0944-1174 1996/11 [Refereed][Not invited]
     
    We modified a novel topical therapeutic method for the treatment of Helicobacter pylori infection to increase its effectiveness and tolerability. Sixty-six patients (with nonulcer dyspepsia, inactive ulcer, or active ulcer) were given lansoprazole (30 mg, h.s.) and pronase (18000 tyrosine units, b.i.d.) orally for 2 days before the topical therapy. One hundred milliliters of 7% sodium bicarbonate solution containing bismuth subnitrate, amoxicillin, metronidazole (at two different regimens), and pronase was instilled into the stomach through an endoscope. A double-lumen tube with a balloon at the tip was inserted into the duodenum along with the endoscope. The balloon was inflated with 25 ml of air and was lodged postbulbarly. The solution was kept in the stomach for 2h, and the patient's position was changed every 14 min from the sitting to the supine, prone, and right lateral position, each position to the supine, prone, and right lateral position, each position being maintained twice, to expose the entire gastric mucosa. The solution was aspirated at the end of the procedure. H. pylori infection was cured in 16/22 (72.7%) of patients with nonulcer dyspepsia, in 21/26 (80.7%) of patients with inactive ulcer, and in 1/18 (5.6%) patients with active ulcer. H. pylori eradication was confirmed 4 weeks after the therapeutic procedure by smear, culture, and histology of antral and corpus biopsy specimens. side effects (loose stools) were observed in two patients only, and one patient had loss of appetite. These effects were transient. This endoscopic topical therapy for H. pylori infection is a safe, effective, and well tolerated procedure. With further modifications of the drug regimens and the method itself, this procedure could be of interest as anti-H. pylori therapy.
  • Yamamoto H, Yasuda Y
    Nihon Geka Gakkai zasshi 11 95 823 - 833 0301-4894 1994/11 [Refereed][Not invited]

MISC

  • YANO Tomonori, YAMAMOTO Hironori, SUNADA Keijiro, HAYASHI Yoshikazu, SATO Hiroyuki, TAKEZAWA Takahito, INO Yuji, KITAMURA Aya, SUGANO Kentaro  Nippon Shokakibyo Gakkai Zasshi  110-  (7)  1198  -1204  2013  [Not refereed][Not invited]
     
    小腸出血の原因病変として,血管性病変,炎症性病変,腫瘍性病変,憩室が挙げられる.初期評価のdynamic造影CTで異常所見があればバルーン内視鏡で精査し,異常所見がなければカプセル内視鏡を行って,バルーン内視鏡の要否を判断する.出血源を同定できれば,その診断に応じた治療を行うが,血管性病変については,拍動性の有無に着目した小腸血管性病変の内視鏡分類を参考に治療方針を決定する.小腸出血の診断率向上には,出血エピソードからできるだけ早いタイミングでの検査が必要であり,カプセル内視鏡とバルーン内視鏡の普及の妨げとなっている保険点数の改訂が望まれる.
  • 矢野 智則, 山本 博徳  臨床外科  67-  (1)  90  -95  2012/01  [Not refereed][Not invited]
  • 岩間 達, 鍵本 聖一, 萩原 真一郎, 辻 由貴, 田附 裕子, 前田 貢作, 矢野 智則, 山本 博徳  日本小児外科学会雑誌  47-  (7)  1102  -1103  2011/12  [Not refereed][Not invited]
  • MISAWA Shunichi, HORIE Hisanaga, KUMANO Hidetoshi, KOINUMA Koji, MIYAKURA Yasuyuki, TOGASHI Kazutomo, YASUDA Yoshikazu, YANO Tomonori, YAMAMOTO Hironori, SUGANO Kentaro, NAGASE Michitaka  Nippon Shokakibyo Gakkai Zasshi  108-  (3)  429  -435  2011/03  [Not refereed][Not invited]
     
    Between 1989 and 2009, 10 patients with small bowel adenocarcinoma were treated in our hospital. These tumors appeared in the jejunum in 6 patients and in the ileum in the remaining 4 patients. All patients had some symptoms. The median size of the tumors was 50mm(30-110mm). All tumors were advanced type 2 lesion with severe stricture. Histologically there were 8 well, 1 moderately and 1 poorly differentiated adenocarcinomas. There were 8 tumors invading the serosa and 2 tumors invaded other organs. Positive lymph nodes were identified in 6 cases. Liver metastasis and peritoneal dissemination were identified in 3 and 4 cases, respectively. Eight cases were diagnosed as small bowel adenocarcinoma preoperatively by double balloon endoscopy. The 4 patients with stage II tumor and 2 patients with stage III tumor underwent curative-intent surgery. The 4 patients with stage II tumor are all surviving without evidence of disease now.
  • YANO Tomonori, NISHIMURA Naoyuki, MIURA Yosimasa, SHINHATA Hakuei, SATO Hiroyuki, HAYASHI Yoshikazu, MIYATA Tomohiko, SUNADA Keijiro, YAMAMOTO Hironori  Nihon Naika Gakkai Zasshi  100-  (1)  102  -107  2011/01  [Not refereed][Not invited]
     
    カプセル内視鏡とバルーン内視鏡という新たな方法が登場して小腸疾患に対する診断・治療戦略が大きく変化した.これまで困難であった小腸良性腫瘍の内視鏡的診断が可能になり,正確な診断をもとにして治療方針を決定できるようになった.また,内視鏡的治療も可能になったことで,Peutz-Jeghers syndromeの小腸ポリープなど,開腹手術となる前に早期発見して治療することが重要となってきている.
  • 宮田 知彦, 山本 博徳  内科  106-  (6)  1081  -1085  2010/12  [Not refereed][Not invited]
  • 辻 由貴, 前田 貢作, 馬場 勝尚, 田附 裕子, 木島 茂喜, 相原 敏則, 矢野 智則, 山本 博徳  日本小児外科学会雑誌  46-  (6)  1015  -1015  2010/10  [Not refereed][Not invited]
  • YANO Tomonori, YAMAMOTO Hironori  GASTROENTEROLOGICAL ENDOSCOPY  52-  (9)  2730  -2737  2010/09  [Not refereed][Not invited]
     
    The use of balloon assisted endoscopy has enabled endoscopic diagnoses of, and treatment for small-intestinal bleeding. Since the balloon assisted endoscope has an accessory channel and provides good maneuverability in the distal small-intestine, it is possible to perform endoscopic treatment such as cauterization, hemoclipping, injection, polypectomy and EMR. Vascular lesions, ulcerative lesions, neoplastic lesions, varices and the diverticulum can be sources of bleeding and appropriate endoscopic hemostatic methods should be selected according to the type of lesion on an individual basis.
  • 辻 由貴, 前田 貢作, 馬場 勝尚, 田附 裕子, 相原 敏則, 矢野 智則, 山本 博徳  日本小児外科学会雑誌  46-  (3)  407  -407  2010/05  [Not refereed][Not invited]
  • 佐藤 貴一, 山本 博徳  日本消化器内視鏡学会雑誌 = Gastroenterological endoscopy  52-  (1)  104  -107  2010/01  [Not refereed][Not invited]
  • KAWANO Youichi, MIZUTA Koichi, EGAMI Satoshi, HAYASHIDA Makoto, SANADA Yukihiro, HYODO Masanobu, YASUDA Yoshikazu, YAMAMOTO Hironori, KOBAYASHI Eiji, KAWARASAKI Hideo, SHIMIZU Atsushi  移植  44-  (5)  438  -445  2009/10  [Not refereed][Not invited]
  • YOSHIZAWA Mitsuyo, OSAWA Hiroyuki, YAMAMOTO Hironori, SATOH Kiichi, NAKANO Hidetoshi, TSUKUI Mamiko, SUGANO Kentaro  GASTROENTEROLOGICAL ENDOSCOPY  51-  (8)  1748  -1752  2009/08  [Not refereed][Not invited]
     
    Background : Magnifying narrow band imaging system is useful for the diagnosis of early gastric cancer. However, it is difficult for the operator of the scope to maintain the correct distance between the tip of the endoscope and the gastric mucosa for appropriate visualization. The newly developed optimal band imaging system can reconstruct good spectral images derived from ordinary endoscopic images and enhance the mucosal surface without magnification as well as with low magnification. This imaging technique is based on narrowing the bandwidth of the conventional image arithmetically, using spectral estimation technology.<BR>Methods : We evaluated endoscopic features of 30 lesions with elevated-type, 32 lesions with depressed-type and two lesions with fiat-type early gastric cancer using this new system.<BR>Results : We found the best images in all cases of early gastric cancers by using a specific combination of the following three wavelengths available in this system : 470 nm for blue, 500 nm for green and 550 nm for red. The optimal band images showed the depressed-type early gastric cancer as reddish lesions distinct from the surrounding yellowish non-cancerous area, leading to a clear demarcation line between the cancerous and non-cancerous mucosa without magnification. Moreover, 30-40-fold magnified optimal band images showed a clearly irregular microvascular pattern or a microstructure pattern of the mucosal surface in all types of gastric cancers.<BR>Conclusion : This new system can provide useful information for diagnosing various types of early gastric cancers without and with low magnification.
  • 井上 賢之, 冨樫 一智, 鯉沼 広治, 宮田 知彦, 熊野 秀俊, 宮倉 安幸, 堀江 久永, 山本 博徳, 安田 是和  日本消化器外科学会雑誌  42-  (7)  2009/07  [Not refereed][Not invited]
  • Sunada Keijiro, Nishimura Naoyuki, Fukushima Hiroki, Hayashi Yoshikazu, Arashiro Masayuki, Yasno Tomonori, Miyata Tomohiko, Yamamoto Hironori, Sugano Kentaro  Nihon Naika Gakkai Zasshi  98-  (1)  94  -103  2009/01  [Not refereed][Not invited]
     
    近年ダブルバルーン内視鏡(double balloon enteroscopy;DBE)カプセル内視鏡(capsule endoscopy;CE)が開発され,全小腸の内視鏡観察が可能となった.DBEで観察されるCrohn病の小腸病変の特徴は,アフタ性潰瘍,類円形潰瘍,不整型潰瘍,縦走潰瘍などである.潰瘍は腸間膜付着側に偏在する傾向があり,他疾患との鑑別に役立つ.Crohn病は,その経過中に狭窄病変を引き起こすことが臨床的に大きな問題であるが,従来外科手術に頼らざるを得なかった小腸の狭窄に対しても,内視鏡的バルーン拡張術が行えるようになった.
  • YANO Tomonori, YAMAMOTO Hironori, SUNADA Keijiro, ARASHIRO Masayuki, MIYATA Tomohiko, SUGANO Kentaro  Nippon Shokakibyo Gakkai Zasshi  106-  (1)  19  -25  2009/01  [Not refereed][Not invited]
     
    ダブルバルーン内視鏡とシングルバルーン内視鏡は,バルーン内視鏡と総称され,従来であれば術中内視鏡でなければ不可能であった深部小腸の病変に対する内視鏡診断·治療を可能にした.食道,胃や大腸で行われている内視鏡治療のほとんどが可能だが,小腸の解剖学的特徴を考慮した工夫と注意が必要である.また,現状では,バルーン内視鏡の有効長と鉗子口径に対応した処置具が限られており,今後の開発が待たれる.バルーン内視鏡は,今後需要が増えていくと考えられるが,その有用性とコストに見合った保険点数が算定されておらず,普及の障害となっている.医療レベルの地域間格差を解消するためにも,適正な保険点数の算定が望まれる.
  • 山本 博徳  日本消化器内視鏡学会雑誌 = Gastroenterological endoscopy  50-  3542  -3546  2008/12  [Not refereed][Not invited]
  • SANADA Yukihiro, KAWANO Youichi, MIZUTA Koichi, EGAMI Satoshi, HAYASHIDA Makoto, HISHIKAWA Shuji, YANO Tomonori, YAMAMOTO Hironori, FUJIWARA Takehito, SAKUMA Yasunaru, HYODO Masanobu, YASUDA Yoshikazu, KOBAYASHI Eiji, KAWARASAKI Hideo  移植  43-  (5)  378  -382  2008/10  [Not refereed][Not invited]
  • 茂森 昌人, 矢野 智則, 山本 博徳  日本医事新報  (4402)  49  -52  2008/09  [Not refereed][Not invited]
  • 北出 卓, 砂田 圭二郎, 山本 博徳  日本医事新報  (4397)  49  -52  2008/08  [Not refereed][Not invited]
  • 矢野 智則, 山本 博徳  Japanese journal of clinical medicine  66-  (7)  1335  -1341  2008/07  [Not refereed][Not invited]
  • YAMAMOTO Hironori  Gastroenterol Endosc  49-  (12)  3002  -3008  2007/12  [Not refereed][Not invited]
  • YANO T, YAMAMOTO H  Nippon Daicho Komonbyo Gakkai Zasshi  60-  (10)  940  -946  2007/10  [Not refereed][Not invited]
     
    The advent of video capsule endoscopy and double balloon endoscopy has been changing the diagnostic algorithm for small bowel diseases whose main diagnostic modality has been barium examination. The double balloon endoscopy uses two balloons, one attached to the tip of an endoscope and another at the distal end of an overtube. By using these balloons to grip the intestinal wall, the endoscope can be inserted further without forming redundant loops in the intestines. The double balloon endoscopy technique enables endoscopic scrutiny, biopsy and treatments in any part of the small bowel in the same way as in the stomach and the colon. The authors describe the principle of insertion, characteristics, selection of endoscope type and insertion route, as well as practical insertion procedures using both the oral and anal routes.
  • 砂田 圭二郎, 山本 博徳, 林 芳和  Japanese journal of clinical medicine  65-  (10)  1866  -1874  2007/10  [Not refereed][Not invited]
  • 矢野 智則, 山本 博徳  臨床放射線  52-  (11)  1502  -1510  2007/10  [Not refereed][Not invited]
  • 川野 陽一, 水田 耕一, 江上 聡, 石川 りか, 藤原 岳人, 安田 是和, 矢野 智則, 山本 博徳, 河原崎 秀雄  日本消化器外科学会雑誌  40-  (7)  2007/07  [Not refereed][Not invited]
  • 山本 博徳  日本医師会雑誌  136-  (3)  519  -524  2007/06  [Not refereed][Not invited]
  • 砂田 圭二郎, 山本 博徳, 矢野 智則  最新医学  62-  (0)  605  -617  2007/03  [Not refereed][Not invited]
  • 山本 博徳  日本消化器内視鏡学会雑誌 = Gastroenterological endoscopy  48-  2006/09  [Not refereed][Not invited]
  • 川野 陽一, 水田 耕一, 菱川 修司, 齋藤 武, 眞田 幸弘, 藤原 岳人, 安田 是和, 山本 博徳, 菅野 健太郎, 河原崎 秀雄  日本消化器外科学会雑誌  39-  (7)  2006/07  [Not refereed][Not invited]
  • KITA Hiroto, YAMAMOTO Hironori, YANO Tomonori, IWAMOTO Michiko, MIYATA Tomohiko, SUNADA Keijiro, SUGANO Kentaro  日本消化器内視鏡学会雑誌 = Gastroenterological endoscopy  48-  (3)  348  -355  2006/03  [Not refereed][Not invited]
  • YAMAMOTO Hironori, KITA Hiroto, SUNADA Keijiro, MIYATA Tomohiko, YANO Tomonori, IWAMOTO Michiko, OMATA Toshiaki, SHINHATA Hakuei, TONE Yukio, FUJIEDA Shinji, ABE Taro, IDO Kenichi, SUGANO Kentaro  GASTROENTEROLOGICAL ENDOSCOPY  47-  (12)  2672  -2680  2005/12  [Not refereed][Not invited]
     
    When the feasibility of performing ESD in the colon is discussed, it is important to understand the difference of the features between the colon and stomach. When piecemeal EMR or ESD is chosen for the treatment of laterally spreading tumors in the colon, one should select one of the procedures by considering the risk/benefit ratio. In order to perform ESD safely in the colon, it is almost necessary to use sodium hyaluronate solution for the injection to create a submucosal cushion. Local injection of sodium hyaluronate can provide thickness and some stiffness to the thin and soft colonic wall. Safety margin for ESD is obtained from the long-lasting thickening created by the injection of sodium hyaluronate. For the mucosal incision and the submucosal dissection, electrosurgical knives suitable for front viewing approach should be selected. It is also useful to use a transparent hood attached to the endoscope tip to assist the incision and the dissection. A good strategy to maintain the submucosal thickening throughout the procedure and wise usage of gravity are also important factors for successful ESD. By selecting an appropriate technique, ESD can be performed safely even in the colon. Moreover, development and improvement of the instruments and techniques, ESD in the colon will become applicable more and more.
  • 山本 博徳  最新医学  60-  (12)  2643  -2648  2005/12  [Not refereed][Not invited]
  • YAMAMOTO Hironori, KITA Hiroto, SUNADA Keijiro, YANO Tomonori, HAYASHI Yoshikazu, SATO Hiroyuki, AJIBE Hironari, IWAMOTO Michiko, IDO Kenichi, SUGANO Kentaro  Gastroenterological Endoscopy  47-  (10)  2353  -2360  2005/10  [Not refereed][Not invited]
  • 喜多 宏人, 山本 博徳, 砂田 圭二郎  消化器医学  3-  123  -129  2005  [Not refereed][Not invited]
  • IDO Kenichi, TOGASHI Kazutomo, YAMAMOTO Hironori, SATOH Kiichi  Gastroenterol Endosc.  46-  (9)  2079  -2085  2004/09  [Not refereed][Not invited]
  • YAMAMOTO Hironori, KITA Hiroto, SUNADA Keijiro, YANO Tomonori, HAYASHI Yoshikazu, SATO Hiroyuki, IWAMOTO Michiko, SUGANO Kentaro  Nippon Shokakibyo Gakkai Zasshi  101-  (9)  976  -982  2004/09  [Not refereed][Not invited]
     
    2003年11月から市販され始めたFTSダブルバルーン電子内視鏡システムは小腸への内視鏡挿入を可能とするために考え出されたダブルバルーン法に基づく新たな内視鏡システムである. この内視鏡システムの特徴は全小腸の内視鏡観察をも実現した挿入性のみならず, 深部小腸においても発揮される優れた操作性にあるといえる. 内視鏡コントロールの基点はオーバーチューブのバルーンでの把持部であり, 消化管の任意の部位に置くことが出来る. ダブルバルーン内視鏡の登場によりこれまで内視鏡到達が困難であった小腸にも内視鏡的精査, 治療を行うことが可能となった. 本稿ではわれわれの試作機時代からの使用経験をもとにその有用性について紹介した.
  • 山本 博徳, 喜多 宏人, 砂田 圭二郎, 矢野 智則, 林 芳和, 佐藤 博之, 岩本 美智子, 井戸 健一, 菅野 健太郎  日本内科学会雑誌  93-  (6)  1189  -1199  2004/06  [Not refereed][Not invited]
     
    近年小腸内視鏡検査に新しい二つの方法が登場した.ワイヤレスカプセル内視鏡とダブルバルーン内視鏡である.ワイヤレスカプセル内視鏡は苦痛もなく,被検者を医療施設に拘束することも無く全小腸の内視鏡画像検査を可能とした画期的検査法である.小腸疾患の初期検査としての有用性が期待されるが生検,内視鏡治療が出来ないこと,狭窄部での滞留の危険性がある事などが問題である.
    ダブルバルーン内視鏡は内視鏡先端とオーバーチューブ先端の二つのバルーンを組み合わせて操作し,腸管を短縮しながら挿入していく新しい内視鏡挿入概念に基づいた内視鏡である.経口的,経肛門的のどちらからのルートでも挿入でき,消化管全域の内視鏡検査が可能となった.深部小腸においても操作性に優れ,任意の部位での往復観察,生検,内視鏡処置が可能である.
    これら二つの新しい小腸内視鏡検査により小腸疾患へのアプローチに変革がもたらされる事が予想される.
  • 山本 博徳  日本バイオレオロジー学会年会抄録集  26-  53  -53  2003/06  [Not refereed][Not invited]
  • 山本 博徳  月刊地域医学  16-  (11)  744  -749  2002/11  [Not refereed][Not invited]
  • 柏木 伸仁, 杉村 一仁, 朝倉 均, 山本 博徳, 小祝 宏文, 吉川 敏一, 平石 勝也, 澤田 康史, 下山 孝  日本アフェレシス学会雑誌  21-  (0)  105  -105  2002/06  [Not refereed][Not invited]
  • 山本 博徳  月刊地域医学  12-  (1)  36  -40  1998/01  [Not refereed][Not invited]


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