sato shigeru

FacultyDivisionofBiology
Job titleAssociate ProfessorWeb site

Profile

Research Keywords

    Sensory placode, Neural crest, Vertebrate evolution

Research Areas

  • Basic medicine / General medical chemistry
  • Basic medicine / Pathological medical chemistry
  • Neuroscience / Neuroscience in general
  • Basic biology / Genetics/Genome dynamics
  • Biological science / Developmental biology
  • Biological science / Evolutionary biology
  • Basic medicine / General anatomy (including histology/embryology)
  • Clinical surgery / Otorhinolaryngology

Career

  • Jichi Medical University, Assistant Professor

Academic Background

  • -
    1995
    Graduate School, Division of Natural Science, Tohoku University (japan)
  • -
    1989
    Faculty of Science, Tohoku University (japan)

Research Activities

Papers(paper)

  • Six1 is a key regulator of the developmental and evolutionary architecture of sensory neurons in craniates.
    Yajima H, Suzuki M, Ochi H, Ikeda K, Sato S, Yamamura KI, Ogino H, Ueno N, Kawakami K
    BMC biology 12 40 May 2014
  • FGFR1-Frs2/3 signalling maintains sensory progenitors during inner ear hair cell formation.
    Ono K, Kita T, Sato S, O'Neill P, Mak SS, Paschaki M, Ito M, Gotoh N, Kawakami K, Sasai Y, Ladher RK
    PLoS genetics 10 e1004118 Jan. 2014
  • Regulation of Six1 expression by evolutionarily conserved enhancers in tetrapods.
    Sato S, Ikeda K, Shioi G, Nakao K, Yajima H, Kawakami K
    Developmental biology 368 95-108 Aug. 2012
  • Six family genes control the proliferation and differentiation of muscle satellite cells.
    Yajima H, Motohashi N, Ono Y, Sato S, Ikeda K, Masuda S, Yada E, Kanesaki H, Miyagoe-Suzuki Y, Takeda S, Kawakami K
    Experimental cell research 316 2932-2944 Oct. 2010
  • Conserved expression of mouse Six1 in the pre-placodal region (PPR) and identification of an enhancer for the rostral PPR.
    Sato S, Ikeda K, Shioi G, Ochi H, Ogino H, Yajima H, Kawakami K
    Developmental biology 344 158-171 Aug. 2010
  • Multiple evolutionarily conserved enhancers control expression of Eya1.
    Ishihara T, Sato S, Ikeda K, Yajima H, Kawakami K
    Developmental dynamics : an official publication of the American Association of Anatomists 237 3142-3156 Nov. 2008
  • Differential expression of Eya1 and Eya2 during chick early embryonic development.
    Ishihara T, Ikeda K, Sato S, Yajima H, Kawakami K
    Gene expression patterns : GEP 8 357-367 May 2008
  • Six1 is essential for early neurogenesis in the development of olfactory epithelium.
    Ikeda K, Ookawara S, Sato S, Ando Z, Kageyama R, Kawakami K
    Developmental biology 311 53-68 Nov. 2007
  • Regulation of melanoblast and retinal pigment epithelium development by Xenopus laevis Mitf.
    Kumasaka M, Sato S, Yajima I, Goding CR, Yamamoto H
    Developmental dynamics : an official publication of the American Association of Anatomists 234 523-534 Nov. 2005
  • Slc12a2 is a direct target of two closely related homeobox proteins, Six1 and Six4.
    Ando Z, Sato S, Ikeda K, Kawakami K
    The FEBS journal 272 3026-3041 Jun. 2005
Display all
Papers(paper)close
  • Six1 is a key regulator of the developmental and evolutionary architecture of sensory neurons in craniates.
    Yajima H, Suzuki M, Ochi H, Ikeda K, Sato S, Yamamura KI, Ogino H, Ueno N, Kawakami K
    BMC biology 12 40 May 2014
  • FGFR1-Frs2/3 signalling maintains sensory progenitors during inner ear hair cell formation.
    Ono K, Kita T, Sato S, O'Neill P, Mak SS, Paschaki M, Ito M, Gotoh N, Kawakami K, Sasai Y, Ladher RK
    PLoS genetics 10 e1004118 Jan. 2014
  • Regulation of Six1 expression by evolutionarily conserved enhancers in tetrapods.
    Sato S, Ikeda K, Shioi G, Nakao K, Yajima H, Kawakami K
    Developmental biology 368 95-108 Aug. 2012
  • Six family genes control the proliferation and differentiation of muscle satellite cells.
    Yajima H, Motohashi N, Ono Y, Sato S, Ikeda K, Masuda S, Yada E, Kanesaki H, Miyagoe-Suzuki Y, Takeda S, Kawakami K
    Experimental cell research 316 2932-2944 Oct. 2010
  • Conserved expression of mouse Six1 in the pre-placodal region (PPR) and identification of an enhancer for the rostral PPR.
    Sato S, Ikeda K, Shioi G, Ochi H, Ogino H, Yajima H, Kawakami K
    Developmental biology 344 158-171 Aug. 2010
  • Multiple evolutionarily conserved enhancers control expression of Eya1.
    Ishihara T, Sato S, Ikeda K, Yajima H, Kawakami K
    Developmental dynamics : an official publication of the American Association of Anatomists 237 3142-3156 Nov. 2008
  • Differential expression of Eya1 and Eya2 during chick early embryonic development.
    Ishihara T, Ikeda K, Sato S, Yajima H, Kawakami K
    Gene expression patterns : GEP 8 357-367 May 2008
  • Six1 is essential for early neurogenesis in the development of olfactory epithelium.
    Ikeda K, Ookawara S, Sato S, Ando Z, Kageyama R, Kawakami K
    Developmental biology 311 53-68 Nov. 2007
  • Regulation of melanoblast and retinal pigment epithelium development by Xenopus laevis Mitf.
    Kumasaka M, Sato S, Yajima I, Goding CR, Yamamoto H
    Developmental dynamics : an official publication of the American Association of Anatomists 234 523-534 Nov. 2005
  • Slc12a2 is a direct target of two closely related homeobox proteins, Six1 and Six4.
    Ando Z, Sato S, Ikeda K, Kawakami K
    The FEBS journal 272 3026-3041 Jun. 2005
  • Pigment cell lineage-specific expression activity of the ascidian tyrosinase-related gene.
    Toyoda R, Kasai A, Sato S, Wada S, Saiga H, Ikeo K, Gojobori T, Numakunai T, Yamamoto H
    Gene 332 61-69 May 2004
  • Isolation and developmental expression of Mitf in Xenopus laevis.
    Kumasaka M, Sato H, Sato S, Yajima I, Yamamoto H
    Developmental dynamics : an official publication of the American Association of Anatomists 230 107-113 May 2004
  • Cloning and functional analysis of ascidian Mitf in vivo: insights into the origin of vertebrate pigment cells.
    Yajima I, Endo K, Sato S, Toyoda R, Wada H, Shibahara S, Numakunai T, Ikeo K, Gojobori T, Goding CR, Yamamoto H
    Mechanisms of development 120 1489-1504 Dec. 2003
  • Isolation and developmental expression of tyrosinase family genes in Xenopus laevis.
    Kumasaka M, Sato S, Yajima I, Yamamoto H
    Pigment cell research / sponsored by the European Society for Pigment Cell Research and the International Pigment Cell Society 16 455-462 Oct. 2003
  • Identification of transcriptional targets for Six5: implication for the pathogenesis of myotonic dystrophy type 1.
    Sato S, Nakamura M, Cho DH, Tapscott SJ, Ozaki H, Kawakami K
    Human molecular genetics 11 1045-1058 May 2002
  • Development of pigment cells in the brain of ascidian tadpole larvae: insights into the origins of vertebrate pigment cells.
    Sato S, Yamamoto H
    Pigment cell research / sponsored by the European Society for Pigment Cell Research and the International Pigment Cell Society 14 428-436 Dec. 2001
  • Functional conservation of the promoter regions of vertebrate tyrosinase genes.
    Sato S, Tanaka M, Miura H, Ikeo K, Gojobori T, Takeuchi T, Yamamoto H
    The journal of investigative dermatology. Symposium proceedings / the Society for Investigative Dermatology, Inc. [and] European Society for Dermatological Research 6 10-18 Nov. 2001
  • Pigment cell-specific expression of the tyrosinase gene in ascidians has a different regulatory mechanism from vertebrates.
    Toyoda R, Sato S, Ikeo K, Gojobori T, Numakunai T, Goding CR, Yamamoto H
    Gene 259 159-170 Dec. 2000
  • Six family genes--structure and function as transcription factors and their roles in development.
    Kawakami K, Sato S, Ozaki H, Ikeda K
    BioEssays : news and reviews in molecular, cellular and developmental biology 22 616-626 Jul. 2000
  • New nomenclature and DNA testing guidelines for myotonic dystrophy type 1 (DM1). The International Myotonic Dystrophy Consortium (IDMC).
    Neurology 54 1218-1221 Mar. 2000
  • Cooperation of six and eya in activation of their target genes through nuclear translocation of Eya.
    Ohto H, Kamada S, Tago K, Tominaga SI, Ozaki H, Sato S, Kawakami K
    Molecular and cellular biology 19 6815-6824 Oct. 1999
  • Structure and developmental expression of the ascidian TRP gene: insights into the evolution of pigment cell-specific gene expression.
    Sato S, Toyoda R, Katsuyama Y, Saiga H, Numakunai T, Ikeo K, Gojobori T, Yajima I, Yamamoto H
    Developmental dynamics : an official publication of the American Association of Anatomists 215 225-237 Jul. 1999
  • Identification of a novel isoform of microphthalmia-associated transcription factor that is enriched in retinal pigment epithelium.
    Amae S, Fuse N, Yasumoto K, Sato S, Yajima I, Yamamoto H, Udono T, Durlu YK, Tamai M, Takahashi K, Shibahara S
    Biochemical and biophysical research communications 247 710-715 Jun. 1998
  • Primary structure of troponin I isoforms from the ascidian Halocynthia roretzi.
    Yuasa HJ, Sato S, Yamamoto H, Takagi T
    Journal of biochemistry 122 374-380 Aug. 1997
  • Neural tube is partially dorsalized by overexpression of HrPax-37: the ascidian homologue of Pax-3 and Pax-7.
    Wada H, Holland PW, Sato S, Yamamoto H, Satoh N
    Developmental biology 187 240-252 Jul. 1997
  • CBP/p300 as a co-factor for the Microphthalmia transcription factor.
    Sato S, Roberts K, Gambino G, Cook A, Kouzarides T, Goding CR
    Oncogene 14 3083-3092 Jun. 1997
  • Structure of the ascidian, Halocynthia roretzi, troponin C gene.
    Yuasa HJ, Sato S, Yamamoto H, Takagi T
    Journal of biochemistry 121 671-676 Apr. 1997
  • Ascidian tyrosinase gene: its unique structure and expression in the developing brain.
    Sato S, Masuya H, Numakunai T, Satoh N, Ikeo K, Gojobori T, Tamura K, Ide H, Takeuchi T, Yamamoto H
    Developmental dynamics : an official publication of the American Association of Anatomists 208 363-374 Mar. 1997
  • Identification of nuclear factors that bind to the mouse tyrosinase gene regulatory region.
    Sato S, Miura H, Yamamoto H, Takeuchi T
    Pigment cell research / sponsored by the European Society for Pigment Cell Research and the International Pigment Cell Society 7 279-284 Oct. 1994
  • Phylogeny of regulatory regions of vertebrate tyrosinase genes.
    Yamamoto H, Kudo T, Masuko N, Miura H, Sato S, Tanaka M, Tanaka S, Takeuchi S, Shibahara S, Takeuchi T
    Pigment cell research / sponsored by the European Society for Pigment Cell Research and the International Pigment Cell Society 5 284-294 Nov. 1992

Papers(other)

  • Isolation and developmental expression of tyrosinase family genes in Xenopus laevis
    Pigment Cell Research 16(5) 455-62 2003
  • Identification of transcriptional targets for Six5: implication for the pathogenesis of myotonic dystrophy type 1
    Human Molecular Genetics 11(9) 1045-1058 2002
  • Development of pigment cells in the brain of ascidian tadpole larvae: insights into the origins of vertebrate pigment cells
    Pigment Cell Research 14(6) 428-436 2001
  • Functional conservation of the promoter regions of vertebrate tyrosinase genes.
    Journal of Investigative Dermatology Symposium Proceedings 6(1) 10-18 2001
  • Pigment cell-specific expression of the tyrosinase gene in ascidians has a different regulatory mechanism from vertebrates
    Gene 259, 159-170 2000
  • Six family genes-structure and function as transcription factors and their roles in development.
    Biossays, 22(7) 616-626 2000
  • An L1 element intronic insertion in the black-eyed white (Mitfmi-bw) gene: the loss of a single Mitf isoform responsible for the pigmentary defect and inner ear deafness
    Human Molecular Genetics 8(8) 1431-1441 1999
  • Structure and developmental expression of the ascidian TRP gene:insights into the evolution of pigment cell-specific gene expression
    Developmental Dynamics 215(3) 225-237 1999
  • Cooperation of Six and Eya in activation of their target genes through nuclear translocation of Eya
    Molecular and Cellular Biology 19(10) 6815-6824 1999
  • Identification of a novel isoform of microphthalmia-associated factor that is enriched in retinal pigment epithelium
    Biochemial and Biophysical Research Communications 247(3) 710-715 1998
Display all
Papers(other)close
  • Isolation and developmental expression of tyrosinase family genes in Xenopus laevis
    Pigment Cell Research 16(5) 455-62 2003
  • Identification of transcriptional targets for Six5: implication for the pathogenesis of myotonic dystrophy type 1
    Human Molecular Genetics 11(9) 1045-1058 2002
  • Development of pigment cells in the brain of ascidian tadpole larvae: insights into the origins of vertebrate pigment cells
    Pigment Cell Research 14(6) 428-436 2001
  • Functional conservation of the promoter regions of vertebrate tyrosinase genes.
    Journal of Investigative Dermatology Symposium Proceedings 6(1) 10-18 2001
  • Pigment cell-specific expression of the tyrosinase gene in ascidians has a different regulatory mechanism from vertebrates
    Gene 259, 159-170 2000
  • Six family genes-structure and function as transcription factors and their roles in development.
    Biossays, 22(7) 616-626 2000
  • An L1 element intronic insertion in the black-eyed white (Mitfmi-bw) gene: the loss of a single Mitf isoform responsible for the pigmentary defect and inner ear deafness
    Human Molecular Genetics 8(8) 1431-1441 1999
  • Structure and developmental expression of the ascidian TRP gene:insights into the evolution of pigment cell-specific gene expression
    Developmental Dynamics 215(3) 225-237 1999
  • Cooperation of Six and Eya in activation of their target genes through nuclear translocation of Eya
    Molecular and Cellular Biology 19(10) 6815-6824 1999
  • Identification of a novel isoform of microphthalmia-associated factor that is enriched in retinal pigment epithelium
    Biochemial and Biophysical Research Communications 247(3) 710-715 1998
  • Primary structure of troponin I isoforms from the ascidian Halocynthia roretzi
    Journal of Biochemistry 122(2) 374-380 1997
  • Structure of the ascidian, Halocynthia roretzi, troponin C gene
    Journal of Biochemistry 121(4) 671-676 1997
  • Neural tube is partially dorsalized by overexpression of HrPax-37: the ascidian homologue of Pax-3 and Pax-7
    Developmental Biology 187(2) 240-252 1997
  • CBP/p300 as a co-factor for the Microphthalmia transcription factor
    Oncogene 14(25) 3083-3092 1997
  • Ascidian tyrosinase gene:its unique structure and expression in the developing brain
    Developmental Dynamics 208(3) 363-374 1997
  • Identification of nuclear factors that bind to the mouse tyrosinase gene regulatory region
    Pigment Cell Research 7(5) 279-284 1994
  • Phylogeny of regulatory regions of vertebrate tyrosinase genes
    Pigment Cell Research 5(5) 284-294 1992
  • Isolation and developmental expression of Mitf in Xenopus laevis
    Developmental Dynamics
  • Cloning and functional analysis of ascidian Mitf in vivo: insights into the origin of vertebrate pigment cells
    Mechanisms of Development

Outside Fund Adoption

  • Cell lineage and functional analyses of the cranial sensory placodes in the vertebrate head
    Ministry of Education, Culture, Sports, Science and Technology:Grants-in-Aid for Scientific Research(基盤研究(C))
    Project Year :2007 - 2008 Investigator(s) : Shigeru SATO
  • Molecular function of Six-Eya-Dach gene regulatory network
  • Development and evolution of sonsory placodes
Display all
Outside Fund Adoptionclose
  • Cell lineage and functional analyses of the cranial sensory placodes in the vertebrate head
    Ministry of Education, Culture, Sports, Science and Technology:Grants-in-Aid for Scientific Research(基盤研究(C))
    Project Year :2007 - 2008 Investigator(s) : Shigeru SATO
  • Molecular function of Six-Eya-Dach gene regulatory network
  • Development and evolution of sonsory placodes


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